pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6410-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! interphase of mitotic cell cycle GO:0051329 156 86 9,000 1,001E-09 2,302E-06 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 7,000 1,052E-09 1,21E-06 ! interphase GO:0051325 159 88 9,000 1,26E-09 9,657E-07 ! response to light stimulus GO:0009416 153 96 8,000 4,819E-08 2,771E-05 ! response to UV GO:0009411 75 46 6,000 5,261E-08 2,42E-05 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 4,000 6,676E-08 2,559E-05 ! apoptotic mitochondrial changes GO:0008637 29 18 4,000 1,87E-07 6,145E-05 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 3,000 2,189E-07 6,293E-05 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 3,000 2,189E-07 5,594E-05 ! cell structure disassembly during apoptosis GO:0006921 24 19 4,000 2,523E-07 5,802E-05 ! apoptotic nuclear changes GO:0030262 24 19 4,000 2,523E-07 5,274E-05 ! motor axon guidance GO:0008045 14 9 3,000 3,917E-07 7,507E-05 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 4,000 4,361E-07 7,715E-05 ! regulation of cell-matrix adhesion GO:0001952 51 22 4,000 5,609E-07 9,215E-05 GO:0010810|regulation of cell-substrate adhesion, ! regulation of B cell proliferation GO:0030888 15 10 3,000 6,49E-07 9,951E-05 ! regulation of mast cell proliferation GO:0070666 64 44 5,000 9,639E-07 1,386E-04 ! T cell homeostasis GO:0043029 20 11 3,000 1,014E-06 1,372E-04 ! negative regulation of mast cell proliferation GO:0070667 17 11 3,000 1,014E-06 1,295E-04 GO:0042130|negative regulation of T cell proliferation, ! regulation of leukocyte proliferation GO:0070663 71 47 5,000 1,439E-06 1,742E-04 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of B cell activation GO:0050864 42 28 4,000 2,018E-06 2,321E-04 ! lymphocyte homeostasis GO:0002260 24 13 3,000 2,171E-06 2,377E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 5,000 2,354E-06 2,461E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 3,021E-06 3,021E-04 ! regulation of cell adhesion GO:0030155 159 83 6,000 3,231E-06 3,097E-04 ! regulation of survival gene product expression GO:0045884 20 15 3,000 4,095E-06 3,768E-04 ! negative regulation of leukocyte proliferation GO:0070664 25 15 3,000 4,095E-06 3,623E-04 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! 2-oxoglutarate metabolic process GO:0006103 7 5 2,000 4,257E-06 3,627E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 4,257E-06 3,497E-04 ! negative regulation of survival gene product expression GO:0008634 6 5 2,000 4,257E-06 3,377E-04 ! valine metabolic process GO:0006573 8 5 2,000 4,257E-06 3,264E-04 ! nucleus organization GO:0006997 49 33 4,000 4,727E-06 3,507E-04 ! regulation of homeostatic process GO:0032844 105 60 5,000 6,188E-06 4,448E-04 ! neuron apoptosis GO:0051402 8 6 2,000 8,467E-06 5,901E-04 ! negative regulation of B cell activation GO:0050869 9 6 2,000 8,467E-06 5,728E-04 ! negative regulation of T cell activation GO:0050868 25 18 3,000 9,02E-06 5,927E-04 ! regulation of T cell proliferation GO:0042129 58 38 4,000 9,697E-06 6,195E-04 ! Ras protein signal transduction GO:0007265 162 100 6,000 1,119E-05 6,958E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 1,256E-05 7,601E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,474E-05 8,69E-04 ! oxaloacetate metabolic process GO:0006107 9 7 2,000 1,474E-05 8,473E-04 ! cellular component disassembly GO:0022411 64 42 4,000 1,604E-05 8,997E-04 ! activation of pro-apoptotic gene products GO:0008633 36 21 3,000 1,733E-05 9,491E-04 ! response to hypoxia GO:0001666 132 72 5,000 1,792E-05 9,588E-04 ! mitochondrion organization GO:0007005 104 73 5,000 1,941E-05 1,015E-03 ! response to oxygen levels GO:0070482 137 74 5,000 2,099E-05 1,073E-03 ! leukocyte homeostasis GO:0001776 33 22 3,000 2,106E-05 1,053E-03 ! positive regulation of cell cycle GO:0045787 77 45 4,000 2,262E-05 1,107E-03 ! succinate metabolic process GO:0006105 14 8 2,000 2,344E-05 1,123E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 2,344E-05 1,1E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 2,344E-05 1,078E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 2,344E-05 1,057E-03 ! regulation of activated T cell proliferation GO:0046006 15 9 2,000 3,497E-05 1,547E-03 ! phosphagen metabolic process GO:0006599 12 9 2,000 3,497E-05 1,518E-03 GO:0006600|creatine metabolic process, ! negative regulation of lymphocyte activation GO:0051250 37 25 3,000 3,578E-05 1,524E-03 ! negative regulation of leukocyte activation GO:0002695 39 27 3,000 4,905E-05 2,051E-03 ! DNA catabolic process GO:0006308 67 54 4,000 5,542E-05 2,276E-03 ! positive regulation of multicellular organism growth GO:0040018 38 28 3,000 5,689E-05 2,296E-03 ! focal adhesion formation GO:0048041 24 11 2,000 6,793E-05 2,694E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 7,205E-05 2,809E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 7,205E-05 2,762E-03 ! negative regulation of cell activation GO:0050866 44 30 3,000 7,526E-05 2,838E-03 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 7,676E-05 2,848E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 7,837E-05 2,861E-03 ! tRNA modification GO:0006400 14 12 2,000 9,007E-05 3,237E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 9,991E-05 3,535E-03 ! neuron migration GO:0001764 46 34 3,000 1,244E-04 4,335E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 1,396E-04 4,793E-03 ! G1 phase of mitotic cell cycle GO:0000080 23 14 2,000 1,474E-04 4,985E-03 ! regulation of erythrocyte differentiation GO:0045646 27 14 2,000 1,474E-04 4,912E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 1,832E-04 6,019E-03 ! defense response to virus GO:0051607 27 15 2,000 1,832E-04 5,934E-03 ! pigmentation GO:0043473 74 38 3,000 1,934E-04 6,178E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 2,142E-04 6,749E-03 ! G1 phase GO:0051318 27 16 2,000 2,242E-04 6,969E-03 ! branched chain family amino acid metabolic process GO:0009081 24 16 2,000 2,242E-04 6,876E-03 ! JAK-STAT cascade GO:0007259 53 40 3,000 2,366E-04 7,161E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 2,708E-04 8,087E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 2,708E-04 7,984E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 2,708E-04 7,883E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 2,864E-04 8,235E-03 ! gland development GO:0048732 148 77 4,000 3,011E-04 8,55E-03 ! visual learning GO:0008542 35 18 2,000 3,231E-04 9,062E-03 ! T cell activation GO:0042110 134 79 4,000 3,393E-04 9,403E-03 ! response to protein stimulus GO:0051789 111 81 4,000 3,811E-04 0,01043576 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 3,815E-04 0,01032424 ! response to alkaloid GO:0043279 32 19 2,000 3,815E-04 0,01020419 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 3,815E-04 0,0100869 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 3,815E-04 9,972E-03 ! negative regulation of immune system process GO:0002683 73 47 3,000 4,432E-04 0,011454 ! regulation of neuron apoptosis GO:0043523 77 47 3,000 4,432E-04 0,01132673 ! positive regulation of B cell activation GO:0050871 31 20 2,000 4,464E-04 0,01128237 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 4,763E-04 0,01190642 ! regulation of protein localization GO:0032880 132 85 4,000 4,763E-04 0,01177839 ! regulation of membrane potential GO:0042391 128 85 4,000 4,763E-04 0,01165309 ! regulation of lymphocyte differentiation GO:0045619 69 48 3,000 4,807E-04 0,0116376 ! cell cycle arrest GO:0007050 150 86 4,000 5,026E-04 0,01204153 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 5,179E-04 0,01228008 ! visual behavior GO:0007632 39 21 2,000 5,179E-04 0,01215478 ! cell aging GO:0007569 32 21 2,000 5,179E-04 0,012032 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 5,179E-04 0,01191168 ! regulation of intracellular transport GO:0032386 78 49 3,000 5,203E-04 0,01184952 ! positive regulation of growth GO:0045927 67 50 3,000 5,623E-04 0,01267904 ! regulation of multicellular organism growth GO:0040014 65 50 3,000 5,623E-04 0,01255594 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 5,659E-04 0,01251529 ! skeletal myofibril assembly GO:0014866 7 5 1,000 5,659E-04 0,01239609 ! cardiac muscle fiber development GO:0048739 7 5 1,000 5,659E-04 0,01227915 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 5,659E-04 0,01216439 ! microvillus organization GO:0032528 7 5 1,000 5,659E-04 0,01205176 GO:0030033|microvillus assembly, ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 5,659E-04 0,01194119 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 5,659E-04 0,01183263 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 5,659E-04 0,01172603 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 8 5 1,000 5,659E-04 0,01162134 ! forebrain morphogenesis GO:0048853 13 5 1,000 5,659E-04 0,01151849 ! negative regulation of osteoblast differentiation GO:0045668 5 5 1,000 5,659E-04 0,01141745 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 5,659E-04 0,01131817 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 5,659E-04 0,0112206 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 5,659E-04 0,0111247 GO:0022011|myelination in the peripheral nervous system, ! regulation of T cell activation GO:0050863 128 89 4,000 5,882E-04 0,01146583 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 5,963E-04 0,01152605 ! dicarboxylic acid metabolic process GO:0043648 33 22 2,000 5,963E-04 0,01143 ! positive regulation of cell migration GO:0030335 92 51 3,000 6,066E-04 0,01152992 ! leukocyte differentiation GO:0002521 143 90 4,000 6,191E-04 0,01167141 ! response to virus GO:0009615 122 91 4,000 6,511E-04 0,01217568 ! aging GO:0007568 79 52 3,000 6,533E-04 0,01211729 ! establishment of organelle localization GO:0051656 85 52 3,000 6,533E-04 0,01202035 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 6,82E-04 0,01244918 ! myelination GO:0042552 35 23 2,000 6,82E-04 0,01235116 ! regulation of transcription factor import into nucleus GO:0042990 46 23 2,000 6,82E-04 0,01225466 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 6,82E-04 0,01215966 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 6,82E-04 0,01206613 ! lymphocyte proliferation GO:0046651 36 23 2,000 6,82E-04 0,01197402 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 6,82E-04 0,01188331 ! regulation of bone remodeling GO:0046850 90 53 3,000 7,025E-04 0,01214812 ! regulation of tissue remodeling GO:0034103 91 54 3,000 7,542E-04 0,01294596 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 7,751E-04 0,01320555 ! mitochondrial membrane organization GO:0007006 39 24 2,000 7,751E-04 0,01310845 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 1,000 8,446E-04 0,01417991 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 8,446E-04 0,01407715 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 8,446E-04 0,01397588 ! DNA ligation during DNA repair GO:0051103 9 6 1,000 8,446E-04 0,01387605 ! pigment granule organization GO:0048753 11 6 1,000 8,446E-04 0,01377764 ! ER overload response GO:0006983 7 6 1,000 8,446E-04 0,01368061 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 8,446E-04 0,01358494 ! astrocyte development GO:0014002 14 6 1,000 8,446E-04 0,01349061 ! positive regulation of B cell differentiation GO:0045579 9 6 1,000 8,446E-04 0,01339757 ! Schwann cell development GO:0014044 14 6 1,000 8,446E-04 0,0133058 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 8,446E-04 0,01321529 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 8,446E-04 0,01312599 ! regulation of Rac protein signal transduction GO:0035020 8 6 1,000 8,446E-04 0,0130379 ! positive regulation of cell motion GO:0051272 99 56 3,000 8,658E-04 0,01327503 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 8,759E-04 0,01334192 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of chromosome organization GO:0033044 35 25 2,000 8,759E-04 0,01325414 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 8,759E-04 0,01316752 ! leukocyte proliferation GO:0070661 39 25 2,000 8,759E-04 0,01308201 GO:0032943|mononuclear cell proliferation, ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 9,847E-04 0,0146116 ! negative regulation of neuron apoptosis GO:0043524 42 27 2,000 1,102E-03 0,01624227 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,177E-03 0,01723662 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,177E-03 0,01712753 ! microtubule bundle formation GO:0001578 8 7 1,000 1,177E-03 0,01701981 ! adrenal gland development GO:0030325 17 7 1,000 1,177E-03 0,01691344 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,177E-03 0,01680838 ! positive regulation of activated T cell proliferation GO:0042104 12 7 1,000 1,177E-03 0,01670463 ! asymmetric protein localization GO:0008105 8 7 1,000 1,177E-03 0,01660215 ! organ growth GO:0035265 11 7 1,000 1,177E-03 0,01650091 ! Rac protein signal transduction GO:0016601 7 7 1,000 1,177E-03 0,01640091 ! behavioral fear response GO:0001662 13 7 1,000 1,177E-03 0,01630211 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,177E-03 0,01620449 ! response to UV-B GO:0010224 11 7 1,000 1,177E-03 0,01610803 ! B cell lineage commitment GO:0002326 17 7 1,000 1,177E-03 0,01601272 ! T cell lineage commitment GO:0002360 12 7 1,000 1,177E-03 0,01591853 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 1,000 1,177E-03 0,01582544 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,177E-03 0,01573343 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,177E-03 0,01564248 ! homeostasis of number of cells GO:0048872 84 61 3,000 1,195E-03 0,01579083 ! cell junction assembly GO:0034329 56 28 2,000 1,227E-03 0,01612655 ! ensheathment of neurons GO:0007272 43 28 2,000 1,227E-03 0,01603492 GO:0008366|axon ensheathment, ! negative regulation of cell growth GO:0030308 106 62 3,000 1,27E-03 0,01649695 ! organelle localization GO:0051640 96 62 3,000 1,27E-03 0,01640427 ! ovulation cycle process GO:0022602 41 29 2,000 1,361E-03 0,01748808 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 1,361E-03 0,01739093 ! negative regulation of cell size GO:0045792 108 64 3,000 1,429E-03 0,01816082 ! spindle organization GO:0007051 37 30 2,000 1,504E-03 0,01900523 ! ovulation cycle GO:0042698 43 30 2,000 1,504E-03 0,01890138 ! regulation of caspase activity GO:0043281 97 65 3,000 1,514E-03 0,0189252 ! 'de novo' posttranslational protein folding GO:0051084 9 8 1,000 1,561E-03 0,01940662 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 1,000 1,561E-03 0,01930229 GO:0046579|positive regulation of Ras protein signal transduction, ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,561E-03 0,01919907 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,561E-03 0,01909694 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,561E-03 0,0189959 ! astrocyte differentiation GO:0048708 16 8 1,000 1,561E-03 0,01889592 ! melanin metabolic process GO:0006582 12 8 1,000 1,561E-03 0,01879699 ! Schwann cell differentiation GO:0014037 17 8 1,000 1,561E-03 0,01869909 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,561E-03 0,0186022 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 1,000 1,561E-03 0,01850632 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,561E-03 0,01841141 ! positive regulation of Ras GTPase activity GO:0032320 20 8 1,000 1,561E-03 0,01831748 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,561E-03 0,01822449 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 1,000 1,561E-03 0,01813245 ! axon guidance GO:0007411 99 66 3,000 1,602E-03 0,01851905 ! mammary gland development GO:0030879 57 31 2,000 1,656E-03 0,01904193 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 1,656E-03 0,0189472 ! metanephros development GO:0001656 58 31 2,000 1,656E-03 0,0188534 ! RNA modification GO:0009451 40 31 2,000 1,656E-03 0,01876052 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 1,694E-03 0,01910019 ! learning or memory GO:0007611 123 68 3,000 1,789E-03 0,02007731 ! regulation of muscle development GO:0048634 48 32 2,000 1,817E-03 0,02028707 ! meiosis I GO:0007127 52 32 2,000 1,817E-03 0,02018907 ! peripheral nervous system development GO:0007422 53 32 2,000 1,817E-03 0,020092 ! regulation of protein stability GO:0031647 48 32 2,000 1,817E-03 0,01999587 ! cell junction organization GO:0034330 63 33 2,000 1,988E-03 0,0217698 ! female gonad development GO:0008585 49 33 2,000 1,988E-03 0,02166662 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,988E-03 0,02156442 ! cytokinesis GO:0000910 52 33 2,000 1,988E-03 0,02146318 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 1,991E-03 0,02140238 ! regulation of epithelial cell differentiation GO:0030856 13 9 1,000 1,997E-03 0,0213629 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 1,997E-03 0,02126399 ! elastic fiber assembly GO:0048251 13 9 1,000 1,997E-03 0,021166 ! artery development GO:0060840 19 9 1,000 1,997E-03 0,02106891 GO:0048844|artery morphogenesis, ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,997E-03 0,02097271 ! T cell selection GO:0045058 18 9 1,000 1,997E-03 0,02087738 ! positive regulation of survival gene product expression GO:0045885 13 9 1,000 1,997E-03 0,02078291 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,997E-03 0,02068929 ! DNA ligation GO:0006266 14 9 1,000 1,997E-03 0,02059651 ! oocyte differentiation GO:0009994 12 9 1,000 1,997E-03 0,02050457 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,997E-03 0,02041343 ! spleen development GO:0048536 15 9 1,000 1,997E-03 0,02032311 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 1,000 1,997E-03 0,02023358 ! response to nicotine GO:0035094 16 9 1,000 1,997E-03 0,02014484 ! establishment of cell polarity GO:0030010 12 9 1,000 1,997E-03 0,02005687 ! localization within membrane GO:0051668 15 9 1,000 1,997E-03 0,01996966 ! muscle cell differentiation GO:0042692 104 71 3,000 2,098E-03 0,02088871 ! lymphocyte differentiation GO:0030098 113 71 3,000 2,098E-03 0,02079867 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 2,168E-03 0,02140081 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 2,168E-03 0,02130935 ! regulation of peptidase activity GO:0052547 106 72 3,000 2,208E-03 0,02161444 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 2,208E-03 0,02152286 GO:0045937|positive regulation of phosphate metabolic process, ! tube morphogenesis GO:0035239 118 73 3,000 2,323E-03 0,02254253 ! regulation of action potential in neuron GO:0019228 54 35 2,000 2,358E-03 0,0227889 ! positive regulation of leukocyte proliferation GO:0070665 50 35 2,000 2,358E-03 0,02269355 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! cellular response to hormone stimulus GO:0032870 109 74 3,000 2,441E-03 0,02339588 ! negative regulation of muscle development GO:0048635 12 10 1,000 2,484E-03 0,0237042 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 2,484E-03 0,02360625 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 1,000 2,484E-03 0,0235091 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,484E-03 0,02341275 ! COPI coating of Golgi vesicle GO:0048205 14 10 1,000 2,484E-03 0,02331719 GO:0048200|Golgi transport vesicle coating, ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,484E-03 0,0232224 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,484E-03 0,02312839 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 2,484E-03 0,02303513 ! B cell proliferation GO:0042100 14 10 1,000 2,484E-03 0,02294262 ! fear response GO:0042596 16 10 1,000 2,484E-03 0,02285085 ! negative regulation of ossification GO:0030279 19 10 1,000 2,484E-03 0,02275981 ! regulation of bone resorption GO:0045124 24 10 1,000 2,484E-03 0,02266949 ! alpha-beta T cell activation GO:0046631 16 10 1,000 2,484E-03 0,02257989 ! regulation of B cell differentiation GO:0045577 16 10 1,000 2,484E-03 0,02249099 ! DNA methylation GO:0006306 15 10 1,000 2,484E-03 0,02240279 GO:0006305|DNA alkylation, ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 2,484E-03 0,02231528 ! response to reactive oxygen species GO:0000302 55 36 2,000 2,558E-03 0,02289563 ! cellular amide metabolic process GO:0043603 52 36 2,000 2,558E-03 0,02280689 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 2,558E-03 0,02271883 GO:0046660|female sex differentiation, ! negative regulation of growth GO:0045926 123 75 3,000 2,564E-03 0,0226802 ! response to unfolded protein GO:0006986 99 76 3,000 2,691E-03 0,0237098 ! regulation of protein transport GO:0051223 114 76 3,000 2,691E-03 0,0236193 GO:0070201|regulation of establishment of protein localization, ! learning GO:0007612 67 37 2,000 2,769E-03 0,02421311 ! gliogenesis GO:0042063 71 38 2,000 2,989E-03 0,02604453 ! striated muscle cell differentiation GO:0051146 54 38 2,000 2,989E-03 0,02594625 ! mesenchymal cell development GO:0014031 64 38 2,000 2,989E-03 0,02584871 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 3,021E-03 0,02602053 ! Golgi vesicle budding GO:0048194 17 11 1,000 3,021E-03 0,02592344 ! detection of mechanical stimulus GO:0050982 15 11 1,000 3,021E-03 0,02582707 ! T cell proliferation GO:0042098 20 11 1,000 3,021E-03 0,02573142 ! syncytium formation GO:0006949 15 11 1,000 3,021E-03 0,02563647 ! membrane protein proteolysis GO:0033619 18 11 1,000 3,021E-03 0,02554222 GO:0006509|membrane protein ectodomain proteolysis, ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 3,021E-03 0,02544865 ! digestive tract morphogenesis GO:0048546 15 11 1,000 3,021E-03 0,02535578 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! germ cell migration GO:0008354 18 11 1,000 3,021E-03 0,02526357 ! male sex differentiation GO:0046661 53 39 2,000 3,221E-03 0,02683941 ! T cell differentiation GO:0030217 65 40 2,000 3,463E-03 0,02875152 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 3,463E-03 0,0286481 ! positive regulation of protein transport GO:0051222 55 40 2,000 3,463E-03 0,02854542 ! lactation GO:0007595 20 12 1,000 3,607E-03 0,02962695 ! 'de novo' protein folding GO:0006458 18 12 1,000 3,607E-03 0,02952152 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 3,607E-03 0,02941683 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 1,000 3,607E-03 0,02931288 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 3,607E-03 0,02920967 ! histone acetylation GO:0016573 23 12 1,000 3,607E-03 0,02910718 ! autonomic nervous system development GO:0048483 23 12 1,000 3,607E-03 0,02900541 ! gland morphogenesis GO:0022612 23 12 1,000 3,607E-03 0,02890434 ! peptidyl-lysine modification GO:0018205 18 12 1,000 3,607E-03 0,02880398 ! response to gamma radiation GO:0010332 20 12 1,000 3,607E-03 0,02870431 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 3,607E-03 0,02860533 ! regulation of T cell differentiation GO:0045580 59 41 2,000 3,715E-03 0,02936629 ! microtubule cytoskeleton organization GO:0000226 120 84 3,000 3,862E-03 0,03042078 ! mitochondrial transport GO:0006839 60 42 2,000 3,979E-03 0,03123641 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 3,979E-03 0,03113016 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 4,029E-03 0,03141504 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 4,241E-03 0,03295653 ! lipid localization GO:0010876 24 13 1,000 4,241E-03 0,03284557 GO:0019915|lipid storage, ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 4,241E-03 0,03273535 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 4,241E-03 0,03262587 ! intermediate filament cytoskeleton organization GO:0045104 23 13 1,000 4,241E-03 0,03251711 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 4,241E-03 0,03240908 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,241E-03 0,03230177 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 4,241E-03 0,03219516 ! cellular pigmentation GO:0033059 24 13 1,000 4,241E-03 0,03208926 ! activation of caspase activity GO:0006919 65 43 2,000 4,254E-03 0,03208043 ! tRNA processing GO:0008033 49 43 2,000 4,254E-03 0,03197559 ! vesicle organization GO:0016050 79 43 2,000 4,254E-03 0,03187144 ! response to insulin stimulus GO:0032868 63 43 2,000 4,254E-03 0,03176796 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 4,254E-03 0,03166515 ! skeletal muscle tissue development GO:0007519 123 87 3,000 4,378E-03 0,03248406 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 4,378E-03 0,03237961 ! glycolysis GO:0006096 53 44 2,000 4,54E-03 0,03347017 ! regulation of action potential GO:0001508 71 44 2,000 4,54E-03 0,03336324 ! negative regulation of cell migration GO:0030336 92 44 2,000 4,54E-03 0,03325699 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 4,838E-03 0,03532399 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 4,924E-03 0,03583701 ! neuron maturation GO:0042551 21 14 1,000 4,924E-03 0,03572396 ! myotube differentiation GO:0014902 21 14 1,000 4,924E-03 0,03561162 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,924E-03 0,03549999 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,924E-03 0,03538905 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 1,000 4,924E-03 0,0352788 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 4,924E-03 0,03516924 ! epidermis morphogenesis GO:0048730 29 14 1,000 4,924E-03 0,03506036 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 4,924E-03 0,03495215 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 4,924E-03 0,0348446 GO:0060675|ureteric bud morphogenesis, ! intermediate filament-based process GO:0045103 24 14 1,000 4,924E-03 0,03473772 ! DNA unwinding during replication GO:0006268 21 14 1,000 4,924E-03 0,03463149 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 4,924E-03 0,0345259 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 4,924E-03 0,03442096 ! regulation of ossification GO:0030278 71 46 2,000 5,147E-03 0,03587246 ! metencephalon development GO:0022037 19 15 1,000 5,653E-03 0,03928068 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 5,653E-03 0,03916236 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 5,653E-03 0,03904476 ! lipid phosphorylation GO:0046834 23 15 1,000 5,653E-03 0,03892786 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 5,653E-03 0,03881165 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 1,000 5,653E-03 0,03869614 ! cardiac muscle tissue development GO:0048738 23 15 1,000 5,653E-03 0,03858132 ! cerebral cortex development GO:0021987 29 15 1,000 5,653E-03 0,03846717 ! vesicle coating GO:0006901 25 15 1,000 5,653E-03 0,0383537 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 5,653E-03 0,03824089 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 5,653E-03 0,03812875 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 5,653E-03 0,03801726 ! positive regulation of caspase activity GO:0043280 72 48 2,000 5,8E-03 0,03889272 GO:0010952|positive regulation of peptidase activity, ! regulation of binding GO:0051098 151 95 3,000 5,978E-03 0,03996597 ! angiogenesis GO:0001525 149 95 3,000 5,978E-03 0,03985013 ! regulation of angiogenesis GO:0045765 94 49 2,000 6,144E-03 0,0408444 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 6,144E-03 0,04072669 ! germ cell development GO:0007281 68 49 2,000 6,144E-03 0,04060966 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 6,144E-03 0,0404933 ! endothelial cell migration GO:0043542 22 16 1,000 6,429E-03 0,04224471 ! protein amino acid acetylation GO:0006473 28 16 1,000 6,429E-03 0,04212435 ! glial cell development GO:0021782 24 16 1,000 6,429E-03 0,04200468 ! patterning of blood vessels GO:0001569 24 16 1,000 6,429E-03 0,04188569 ! cellular response to unfolded protein GO:0034620 19 16 1,000 6,429E-03 0,04176737 GO:0030968|endoplasmic reticulum unfolded protein response, ! fructose metabolic process GO:0006000 20 16 1,000 6,429E-03 0,04164971 ! regulation of protein binding GO:0043393 27 16 1,000 6,429E-03 0,04153272 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 1,000 6,429E-03 0,04141638 ! regulation of steroid metabolic process GO:0019218 21 16 1,000 6,429E-03 0,04130069 ! oogenesis GO:0048477 23 16 1,000 6,429E-03 0,04118565 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 3,000 6,431E-03 0,04108442 ! ear development GO:0043583 72 50 2,000 6,501E-03 0,04141736 ! skeletal muscle fiber development GO:0048741 73 50 2,000 6,501E-03 0,04130295 ! muscle fiber development GO:0048747 74 51 2,000 6,869E-03 0,04352328 ! negative regulation of cell motion GO:0051271 104 51 2,000 6,869E-03 0,04340371 ! extracellular structure organization GO:0043062 156 99 3,000 6,906E-03 0,04351687 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 1,000 7,25E-03 0,04555748 ! forelimb morphogenesis GO:0035136 19 17 1,000 7,25E-03 0,04543334 ! regulation of viral genome replication GO:0045069 24 17 1,000 7,25E-03 0,04530988 ! DNA duplex unwinding GO:0032508 25 17 1,000 7,25E-03 0,04518709 GO:0032392|DNA geometric change, ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 7,25E-03 0,04506497 ! membrane budding GO:0006900 29 17 1,000 7,25E-03 0,0449435 ! actin filament bundle formation GO:0051017 26 17 1,000 7,25E-03 0,04482268 ! neuromuscular junction development GO:0007528 23 17 1,000 7,25E-03 0,04470251 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 7,25E-03 0,04458299 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 7,25E-03 0,0444641 ! kidney development GO:0001822 90 53 2,000 7,643E-03 0,04674934 ! glucose catabolic process GO:0006007 66 54 2,000 8,048E-03 0,04909733 ! somitogenesis GO:0001756 24 18 1,000 8,115E-03 0,04937937 ! gut development GO:0048565 26 18 1,000 8,115E-03 0,04924908 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 8,115E-03 0,04911948 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 9,025E-03 0,05448317 ! regeneration GO:0031099 32 19 1,000 9,025E-03 0,05434055 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 9,025E-03 0,05419867 ! smooth muscle contraction GO:0006939 36 19 1,000 9,025E-03 0,05405752 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 9,025E-03 0,05391711 ! plasma membrane fusion GO:0045026 23 19 1,000 9,025E-03 0,05377743 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 9,025E-03 0,05363847 ! renal system process GO:0003014 35 19 1,000 9,025E-03 0,05350023 ! regulation of interleukin-2 production GO:0032663 31 19 1,000 9,025E-03 0,0533627 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 1,000 9,025E-03 0,05322587 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 9,025E-03 0,05308974 ! multicellular organism reproduction GO:0032504 83 57 2,000 9,338E-03 0,05479083 GO:0048609|reproductive process in a multicellular organism, ! gonad development GO:0008406 79 57 2,000 9,338E-03 0,05465141 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 9,794E-03 0,05717139 ! hindlimb morphogenesis GO:0035137 32 20 1,000 9,978E-03 0,05810244 ! spinal cord development GO:0021510 31 20 1,000 9,978E-03 0,05795572 ! response to ethanol GO:0045471 37 20 1,000 9,978E-03 0,05780974 ! multicellular organismal response to stress GO:0033555 32 20 1,000 9,978E-03 0,05766449 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 9,978E-03 0,05751996 ! pallium development GO:0021543 38 20 1,000 9,978E-03 0,05737616 ! DNA modification GO:0006304 28 20 1,000 9,978E-03 0,05723308 ! collagen fibril organization GO:0030199 45 20 1,000 9,978E-03 0,05709071 ! positive regulation of inflammatory response GO:0050729 30 20 1,000 9,978E-03 0,05694905 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 9,978E-03 0,05680808 ! actin filament-based movement GO:0030048 34 20 1,000 9,978E-03 0,05666782 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 2,000 0,0102619 0,05813392 ! activation of MAPK activity GO:0000187 84 59 2,000 0,0102619 0,05799108 ! actin filament organization GO:0007015 95 59 2,000 0,0102619 0,05784895 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01097431 0,06171374 ! myeloid leukocyte differentiation GO:0002573 33 21 1,000 0,01097431 0,06156321 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01097431 0,06141343 ! dendrite development GO:0016358 35 21 1,000 0,01097431 0,06126436 ! regulation of DNA recombination GO:0000018 40 21 1,000 0,01097431 0,06111602 ! ovarian follicle development GO:0001541 30 21 1,000 0,01097431 0,0609684 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01097431 0,06082149 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01097431 0,06067528 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01097431 0,06052978 ! meiosis GO:0007126 96 61 2,000 0,01123678 0,06182918 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 0,01123678 0,06168162 ! urogenital system development GO:0001655 101 61 2,000 0,01123678 0,06153476 ! extracellular matrix organization GO:0030198 103 61 2,000 0,01123678 0,06138859 ! negative regulation of ligase activity GO:0051352 91 61 2,000 0,01123678 0,06124312 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! meiotic cell cycle GO:0051321 97 62 2,000 0,01174359 0,06385404 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01201211 0,06516002 ! molting cycle process GO:0022404 40 22 1,000 0,01201211 0,06500671 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! ureteric bud development GO:0001657 32 22 1,000 0,01201211 0,06485411 ! neural tube closure GO:0001843 33 22 1,000 0,01201211 0,06470222 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,01226338 0,06590136 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 0,01226338 0,06574775 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 0,01226338 0,06559484 ! cell cycle checkpoint GO:0000075 108 64 2,000 0,01279621 0,06828606 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 0,01279621 0,06812799 ! hexose catabolic process GO:0019320 82 64 2,000 0,01279621 0,06797065 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01309117 0,06937715 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01309117 0,06921766 ! vesicle targeting GO:0006903 32 23 1,000 0,01309117 0,06905891 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,01309117 0,06890088 ! osteoblast differentiation GO:0001649 40 23 1,000 0,01309117 0,06874357 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01309117 0,06858698 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01309117 0,0684311 ! liver development GO:0001889 40 23 1,000 0,01309117 0,06827593 ! reproductive structure development GO:0048608 90 65 2,000 0,01334213 0,06942736 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,01390117 0,0721731 ! initiation of viral infection GO:0019059 42 24 1,000 0,01421081 0,07361455 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01421081 0,07344912 ! fat cell differentiation GO:0045444 37 24 1,000 0,01421081 0,07328444 ! response to toxin GO:0009636 38 24 1,000 0,01421081 0,07312049 ! primary neural tube formation GO:0014020 35 24 1,000 0,01421081 0,07295728 ! negative regulation of cell development GO:0010721 56 24 1,000 0,01421081 0,07279479 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 0,01421081 0,07263302 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,01421081 0,07247197 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01421081 0,07231164 ! regulation of osteoblast differentiation GO:0045667 37 24 1,000 0,01421081 0,07215201 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01505878 0,07628898 ! rhythmic process GO:0048511 105 68 2,000 0,01505878 0,07612131 ! male gonad development GO:0008584 33 25 1,000 0,01537036 0,07752596 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01537036 0,07735631 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01537036 0,07718741 GO:0045840|positive regulation of mitosis, ! response to drug GO:0042493 108 69 2,000 0,01565743 0,0784577 ! response to metal ion GO:0010038 103 70 2,000 0,01626934 0,08134671 ! post-embryonic development GO:0009791 42 26 1,000 0,01656917 0,08266614 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,01656917 0,08248721 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01656917 0,08230905 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,01689455 0,08374454 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,01689455 0,08356444 ! monosaccharide catabolic process GO:0046365 91 71 2,000 0,01689455 0,08338512 ! negative regulation of organelle organization GO:0010639 115 72 2,000 0,01753308 0,08635134 ! myofibril assembly GO:0030239 36 27 1,000 0,01780657 0,08751092 GO:0055002|striated muscle cell development, ! response to ionizing radiation GO:0010212 47 27 1,000 0,01780657 0,08732433 ! natural killer cell activation GO:0030101 35 27 1,000 0,01780657 0,08713854 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01780657 0,08695353 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01780657 0,08676931 ! positive regulation of lymphocyte activation GO:0051251 108 74 2,000 0,01885017 0,09166043 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01908192 0,0925916 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01908192 0,09239667 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,01908192 0,09220256 ! neural tube formation GO:0001841 41 28 1,000 0,01908192 0,09200926 ! response to inorganic substance GO:0010035 115 75 2,000 0,01952876 0,09396686 ! regulation of ligase activity GO:0051340 114 75 2,000 0,01952876 0,09377068 ! tRNA metabolic process GO:0006399 95 76 2,000 0,02022075 0,09689107 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,02039458 0,09752086 ! positive regulation of T cell proliferation GO:0042102 44 29 1,000 0,02039458 0,09731853 ! muscle cell development GO:0055001 38 29 1,000 0,02039458 0,09711705 ! telencephalon development GO:0021537 52 29 1,000 0,02039458 0,09691639 ! eye morphogenesis GO:0048592 51 29 1,000 0,02039458 0,09671656 ! tissue homeostasis GO:0001894 42 29 1,000 0,02039458 0,09651756 GO:0048871|multicellular organismal homeostasis, ! regulation of DNA binding GO:0051101 119 77 2,000 0,02092612 0,09882973 ! sex differentiation GO:0007548 105 77 2,000 0,02092612 0,09862721 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,0216449 0,10180627 ! spliceosome assembly GO:0000245 49 30 1,000 0,02174391 0,10206327 ! hindbrain development GO:0030902 45 30 1,000 0,02174391 0,1018554 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02174391 0,10164838 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,02174391 0,1014422 ! response to heat GO:0009408 41 30 1,000 0,02174391 0,10123685 ! establishment of vesicle localization GO:0051650 45 30 1,000 0,02174391 0,10103233 ! alcohol catabolic process GO:0046164 104 80 2,000 0,02312267 0,10722205 ! forebrain development GO:0030900 131 80 2,000 0,02312267 0,10700631 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,0231293 0,10682207 ! glial cell differentiation GO:0010001 55 31 1,000 0,0231293 0,106608 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,0231293 0,10639478 ! segmentation GO:0035282 41 31 1,000 0,0231293 0,10618242 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,0231293 0,1059709 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,02388166 0,10920044 ! positive regulation of cell activation GO:0050867 120 81 2,000 0,02388166 0,10898377 GO:0002696|positive regulation of leukocyte activation, ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,02455012 0,11181242 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,02455012 0,11159145 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,02455012 0,11137135 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02455012 0,11115211 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 1,000 0,02455012 0,11093374 ! vesicle localization GO:0051648 47 32 1,000 0,02455012 0,11071622 ! ossification GO:0001503 134 82 2,000 0,02465406 0,11096737 GO:0060348|bone development, ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,02600576 0,11682275 ! sister chromatid segregation GO:0000819 46 33 1,000 0,02600576 0,11659503 ! ear morphogenesis GO:0042471 42 33 1,000 0,02600576 0,11636819 ! actomyosin structure organization GO:0031032 43 33 1,000 0,02600576 0,11614223 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02600576 0,11591715 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02600576 0,11569294 ! mRNA catabolic process GO:0006402 48 34 1,000 0,02749562 0,1220848 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,02749562 0,12184957 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02749562 0,12161525 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,02749562 0,12138182 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02749562 0,12114929 ! female gamete generation GO:0007292 43 34 1,000 0,02749562 0,12091764 ! female pregnancy GO:0007565 130 87 2,000 0,02871674 0,12604675 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,0290191 0,12713131 ! glycogen metabolic process GO:0005977 48 35 1,000 0,0290191 0,12688962 ! pigment metabolic process GO:0042440 61 35 1,000 0,0290191 0,12664884 ! protein homooligomerization GO:0051260 52 35 1,000 0,0290191 0,12640897 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,03043521 0,13232702 ! reproductive developmental process GO:0003006 127 89 2,000 0,03043521 0,13207735 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,03057562 0,13243677 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 58 36 1,000 0,03057562 0,13218783 ! neural tube development GO:0021915 50 36 1,000 0,03057562 0,13193982 ! glucan metabolic process GO:0044042 49 36 1,000 0,03057562 0,13169274 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,03216459 0,13827766 ! cell fate commitment GO:0045165 141 92 2,000 0,0331125 0,14208721 ! sulfur metabolic process GO:0006790 118 92 2,000 0,0331125 0,14182262 ! carbohydrate catabolic process GO:0016052 121 93 2,000 0,03403137 0,14548729 ! response to oxidative stress GO:0006979 141 94 2,000 0,03496343 0,14919458 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,03543757 0,1509378 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,03543757 0,1506588 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,03543757 0,15038084 ! chromatin remodeling GO:0006338 68 39 1,000 0,03543757 0,15010389 ! JNK cascade GO:0007254 54 39 1,000 0,03543757 0,14982797 ! developmental growth GO:0048589 62 39 1,000 0,03543757 0,14955305 ! cell growth GO:0016049 61 39 1,000 0,03543757 0,14927915 ! synapse organization GO:0050808 55 39 1,000 0,03543757 0,14900624 ! response to calcium ion GO:0051592 58 40 1,000 0,03712046 0,15579755 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,03712046 0,15551377 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,03712046 0,15523101 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03712046 0,15494929 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,03712046 0,15466858 ! B cell differentiation GO:0030183 62 40 1,000 0,03712046 0,15438889 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,03712046 0,15411021 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03746894 0,15527671 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03746894 0,15499743 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03746894 0,15471916 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03746894 0,15444188 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03746894 0,1541656 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03746894 0,15389031 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03746894 0,15361599 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03746894 0,15334265 ! sleep GO:0030431 11 5 0,000 0,03746894 0,15307029 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03746894 0,15279889 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03746894 0,15252845 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03746894 0,15225896 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03746894 0,15199043 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03746894 0,15172284 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03746894 0,15145619 ! tongue development GO:0043586 6 5 0,000 0,03746894 0,15119048 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03746894 0,15092569 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03746894 0,15066184 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03746894 0,1503989 ! cobalt ion transport GO:0006824 9 5 0,000 0,03746894 0,15013688 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03746894 0,14987578 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03746894 0,14961558 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03746894 0,14935628 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03746894 0,14909787 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03746894 0,14884037 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03746894 0,14858374 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03746894 0,14832801 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03746894 0,14807315 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03746894 0,14781916 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03746894 0,14756605 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03746894 0,1473138 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03746894 0,14706241 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03746894 0,14681188 ! malate metabolic process GO:0006108 7 5 0,000 0,03746894 0,1465622 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03746894 0,14631336 ! behavioral response to pain GO:0048266 7 5 0,000 0,03746894 0,14606538 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03746894 0,14581823 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03746894 0,14557191 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03746894 0,14532643 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03746894 0,14508177 ! mating behavior GO:0007617 6 5 0,000 0,03746894 0,14483794 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03746894 0,14459492 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03746894 0,14435272 ! rhythmic behavior GO:0007622 12 5 0,000 0,03746894 0,14411132 ! copulation GO:0007620 7 5 0,000 0,03746894 0,14387074 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03746894 0,14363095 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03746894 0,14339197 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03746894 0,14315377 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03746894 0,14291637 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03746894 0,14267975 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03746894 0,14244392 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03746894 0,14220886 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03746894 0,14197458 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03746894 0,14174107 ! response to protozoan GO:0001562 9 5 0,000 0,03746894 0,14150833 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03746894 0,14127635 ! lymph vessel development GO:0001945 7 5 0,000 0,03746894 0,14104513 ! endochondral ossification GO:0001958 12 5 0,000 0,03746894 0,14081466 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03746894 0,14058495 ! parathyroid gland development GO:0060017 8 5 0,000 0,03746894 0,14035598 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03746894 0,14012776 ! anagen GO:0042640 6 5 0,000 0,03746894 0,13990028 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03746894 0,13967354 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03746894 0,13944753 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03746894 0,13922225 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03746894 0,1389977 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03746894 0,13877387 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03746894 0,13855076 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03746894 0,13832837 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03746894 0,13810669 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03746894 0,13788571 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03746894 0,13766545 ! ovulation GO:0030728 6 5 0,000 0,03746894 0,13744589 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03746894 0,13722702 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 9 5 0,000 0,03746894 0,13700886 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03746894 0,13679138 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03746894 0,1365746 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03746894 0,1363585 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03746894 0,13614308 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03746894 0,13592835 ! polyol catabolic process GO:0046174 7 5 0,000 0,03746894 0,13571429 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03746894 0,1355009 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03746894 0,13528818 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03746894 0,13507613 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03746894 0,13486474 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03746894 0,13465402 ! urea metabolic process GO:0019627 6 5 0,000 0,03746894 0,13444395 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03746894 0,13423454 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03746894 0,13402577 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03746894 0,13381766 ! neutrophil activation GO:0042119 5 5 0,000 0,03746894 0,13361019 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03746894 0,13340336 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03746894 0,13319717 ! response to food GO:0032094 5 5 0,000 0,03746894 0,13299162 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03746894 0,1327867 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03746894 0,13258242 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03746894 0,13237876 ! forebrain neuron development GO:0021884 7 5 0,000 0,03746894 0,13217572 ! melanosome organization GO:0032438 7 5 0,000 0,03746894 0,13197331 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03746894 0,13177152 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03746894 0,13157034 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03746894 0,13136977 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03746894 0,13116982 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03746894 0,13097047 ! nucleoside transport GO:0015858 6 5 0,000 0,03746894 0,13077173 ! nucleoside salvage GO:0043174 7 5 0,000 0,03746894 0,13057359 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03746894 0,13037605 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03746894 0,13017911 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03746894 0,12998276 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03746894 0,12978701 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03746894 0,12959184 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03746894 0,12939725 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03746894 0,12920326 ! depyrimidination GO:0045008 8 5 0,000 0,03746894 0,12900984 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03746894 0,128817 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03746894 0,12862473 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03746894 0,12843304 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03746894 0,12824192 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03746894 0,12805137 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03746894 0,12786138 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03746894 0,12767196 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03746894 0,12748309 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 5 5 0,000 0,03746894 0,12729479 ! response to UV-C GO:0010225 6 5 0,000 0,03746894 0,12710704 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03746894 0,12691984 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03746894 0,12673319 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03746894 0,12654709 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03746894 0,12636154 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03746894 0,12617653 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03746894 0,12599206 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03746894 0,12580813 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03746894 0,12562474 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03746894 0,12544188 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03746894 0,12525955 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03746894 0,12507775 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03746894 0,12489648 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03746894 0,12471573 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03746894 0,12453551 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03746894 0,1243558 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03746894 0,12417662 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03746894 0,12399794 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03746894 0,12381979 ! neural tube patterning GO:0021532 6 5 0,000 0,03746894 0,12364214 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03746894 0,123465 ! histone demethylation GO:0016577 9 5 0,000 0,03746894 0,12328837 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03746894 0,12311224 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03746894 0,12293662 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03746894 0,1227615 ! enteric nervous system development GO:0048484 8 5 0,000 0,03746894 0,12258687 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03746894 0,12241274 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03746894 0,12223911 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03746894 0,12206597 ! transcription termination GO:0006353 8 5 0,000 0,03746894 0,12189331 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03746894 0,12172115 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03746894 0,12154947 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03746894 0,12137827 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03746894 0,12120755 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03746894 0,12103732 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03746894 0,12086756 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03746894 0,12069828 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03746894 0,12052947 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03746894 0,12036113 ! apical protein localization GO:0045176 6 5 0,000 0,03746894 0,12019327 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03746894 0,12002587 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03746894 0,11985893 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03746894 0,11969246 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03746894 0,11952645 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03746894 0,1193609 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03746894 0,11919581 ! glial cell migration GO:0008347 10 5 0,000 0,03746894 0,11903118 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03746894 0,118867 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03746894 0,11870327 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03746894 0,11853999 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03746894 0,11837716 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03746894 0,11821478 ! neural plate development GO:0001840 6 5 0,000 0,03746894 0,11805284 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03746894 0,11789134 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03746894 0,11773029 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03746894 0,11756967 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03746894 0,1174095 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03746894 0,11724976 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03746894 0,11709045 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03746894 0,11693158 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03746894 0,11677313 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03746894 0,11661512 ! spindle assembly GO:0051225 5 5 0,000 0,03746894 0,11645753 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03746894 0,11630037 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03746894 0,11614363 ! organ regeneration GO:0031100 7 5 0,000 0,03746894 0,11598731 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03746894 0,11583141 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03746894 0,11567593 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03746894 0,11552087 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03746894 0,11536623 GO:0055081|anion homeostasis, ! energy reserve metabolic process GO:0006112 59 41 1,000 0,03883354 0,11940793 ! glucose transport GO:0015758 52 41 1,000 0,03883354 0,11924851 ! striated muscle contraction GO:0006941 62 41 1,000 0,03883354 0,11908951 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,03883354 0,11893094 ! biopolymer methylation GO:0043414 62 41 1,000 0,03883354 0,11877278 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,04057625 0,12393808 ! hexose transport GO:0008645 54 42 1,000 0,04057625 0,12377371 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,04057625 0,12360977 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,04057625 0,12344627 ! regulation of cell shape GO:0008360 78 42 1,000 0,04057625 0,12328319 ! positive regulation of binding GO:0051099 59 43 1,000 0,04234806 0,12849675 ! leukocyte migration GO:0050900 60 43 1,000 0,04234806 0,12832746 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,04234806 0,1281586 ! methylation GO:0032259 64 43 1,000 0,04234806 0,1279902 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,04414843 0,13325642 ! ribonucleoprotein complex assembly GO:0022618 70 44 1,000 0,04414843 0,13308177 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,04414843 0,13290758 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,04414843 0,13273384 ! tRNA transcription GO:0009304 11 6 0,000 0,04479381 0,13449838 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04479381 0,13432302 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04479381 0,13414812 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04479381 0,13397368 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04479381 0,13379968 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04479381 0,13362614 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04479381 0,13345305 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04479381 0,13328041 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04479381 0,13310821 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04479381 0,13293646 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04479381 0,13276515 ! prostate gland development GO:0030850 9 6 0,000 0,04479381 0,13259428 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04479381 0,13242385 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04479381 0,13225386 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04479381 0,1320843 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04479381 0,13191518 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04479381 0,13174649 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04479381 0,13157823 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04479381 0,1314104 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04479381 0,131243 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04479381 0,13107603 ! neuron adhesion GO:0007158 9 6 0,000 0,04479381 0,13090947 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04479381 0,13074335 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04479381 0,13057764 ! signal peptide processing GO:0006465 8 6 0,000 0,04479381 0,13041235 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04479381 0,13024748 ! mRNA stabilization GO:0048255 15 6 0,000 0,04479381 0,13008303 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04479381 0,12991899 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04479381 0,12975536 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04479381 0,12959215 ! opsonization GO:0008228 8 6 0,000 0,04479381 0,12942934 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04479381 0,12926695 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04479381 0,12910496 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04479381 0,12894337 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04479381 0,1287822 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04479381 0,12862142 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04479381 0,12846104 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04479381 0,12830107 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04479381 0,12814149 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04479381 0,12798231 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04479381 0,12782352 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04479381 0,12766513 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04479381 0,12750712 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04479381 0,12734951 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04479381 0,12719229 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04479381 0,12703546 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04479381 0,12687901 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04479381 0,12672295 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04479381 0,12656727 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04479381 0,12641197 ! thymic T cell selection GO:0045061 12 6 0,000 0,04479381 0,12625705 ! protein lipoylation GO:0009249 10 6 0,000 0,04479381 0,12610252 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04479381 0,12594836 ! drug transport GO:0015893 6 6 0,000 0,04479381 0,12579457 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04479381 0,12564117 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04479381 0,12548813 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04479381 0,12533547 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04479381 0,12518318 ! histidine metabolic process GO:0006547 6 6 0,000 0,04479381 0,12503126 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04479381 0,1248797 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04479381 0,12472852 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04479381 0,1245777 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04479381 0,12442724 ! adenohypophysis development GO:0021984 10 6 0,000 0,04479381 0,12427715 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04479381 0,12412742 ! hyperosmotic response GO:0006972 8 6 0,000 0,04479381 0,12397805 ! microtubule nucleation GO:0007020 10 6 0,000 0,04479381 0,12382903 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04479381 0,12368038 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04479381 0,12353208 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04479381 0,12338414 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04479381 0,12323655 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04479381 0,12308931 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,04479381 0,12294243 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04479381 0,1227959 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04479381 0,12264971 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04479381 0,12250387 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04479381 0,12235838 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04479381 0,12221323 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04479381 0,12206843 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04479381 0,12192397 ! organic alcohol transport GO:0015850 9 6 0,000 0,04479381 0,12177985 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04479381 0,12163608 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04479381 0,12149264 ! male sex determination GO:0030238 9 6 0,000 0,04479381 0,12134954 ! carnitine transport GO:0015879 8 6 0,000 0,04479381 0,12120677 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04479381 0,12106434 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04479381 0,12092225 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04479381 0,12078049 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04479381 0,12063906 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04479381 0,12049796 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04479381 0,12035719 ! parturition GO:0007567 12 6 0,000 0,04479381 0,12021675 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04479381 0,12007664 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04479381 0,11993685 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04479381 0,11979739 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04479381 0,11965825 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04479381 0,11951944 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04479381 0,11938095 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04479381 0,11924277 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04479381 0,11910492 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04479381 0,11896739 ! macrophage differentiation GO:0030225 10 6 0,000 0,04479381 0,11883017 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04479381 0,11869327 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04479381 0,11855668 ! interaction with symbiont GO:0051702 8 6 0,000 0,04479381 0,11842041 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04479381 0,11828445 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04479381 0,1181488 ! eating behavior GO:0042755 6 6 0,000 0,04479381 0,11801347 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04479381 0,11787844 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04479381 0,11774372 ! response to copper ion GO:0046688 9 6 0,000 0,04479381 0,11760931 ! DNA topological change GO:0006265 8 6 0,000 0,04479381 0,11747521 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04479381 0,11734141 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04479381 0,11720791 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04479381 0,11707472 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04479381 0,11694183 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04479381 0,11680925 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04479381 0,11667696 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04479381 0,11654497 ! gas homeostasis GO:0033483 11 6 0,000 0,04479381 0,11641328 ! hair follicle maturation GO:0048820 7 6 0,000 0,04479381 0,11628189 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04479381 0,1161508 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04479381 0,11602 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04479381 0,11588949 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04479381 0,11575928 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04479381 0,11562936 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04479381 0,11549973 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04479381 0,11537039 ! histone ubiquitination GO:0016574 7 6 0,000 0,04479381 0,11524134 ! regulation of meiosis GO:0040020 10 6 0,000 0,04479381 0,11511258 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04479381 0,1149841 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04479381 0,11485592 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04479381 0,11472801 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04479381 0,1146004 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04479381 0,11447306 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04479381 0,11434601 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04479381 0,11421924 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04479381 0,11409275 ! receptor internalization GO:0031623 9 6 0,000 0,04479381 0,11396654 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04479381 0,11384061 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04479381 0,11371496 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04479381 0,11358959 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04479381 0,11346449 ! protein deubiquitination GO:0016579 8 6 0,000 0,04479381 0,11333967 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04479381 0,11321512 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04479381 0,11309084 ! axonal fasciculation GO:0007413 9 6 0,000 0,04479381 0,11296684 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04479381 0,11284311 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04479381 0,11271965 ! midbrain development GO:0030901 6 6 0,000 0,04479381 0,11259646 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04479381 0,11247353 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04479381 0,11235088 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04479381 0,11222849 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04479381 0,11210637 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04479381 0,11198452 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04479381 0,11186293 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04479381 0,1117416 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04479381 0,11162054 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04479381 0,11149974 ! adult feeding behavior GO:0008343 6 6 0,000 0,04479381 0,1113792 ! blastocyst growth GO:0001832 15 6 0,000 0,04479381 0,11125892 ! pigment granule transport GO:0051904 12 6 0,000 0,04479381 0,1111389 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04479381 0,11101913 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04479381 0,11089963 ! catecholamine transport GO:0051937 7 6 0,000 0,04479381 0,11078038 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04479381 0,11066139 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04479381 0,11054266 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04479381 0,11042418 ! protein prenylation GO:0018342 10 6 0,000 0,04479381 0,11030595 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04479381 0,11018797 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04479381 0,11007025 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04479381 0,10995278 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04479381 0,10983556 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04479381 0,10971859 ! RNA catabolic process GO:0006401 64 45 1,000 0,04597683 0,1124965 ! positive regulation of defense response GO:0031349 59 45 1,000 0,04597683 0,11237695 ! cell maturation GO:0048469 60 45 1,000 0,04597683 0,11225765 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 1,000 0,04783273 0,11666521 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04783273 0,11654162 ! histone modification GO:0016570 68 46 1,000 0,04783273 0,11641829 ! viral infectious cycle GO:0019058 71 47 1,000 0,04971563 0,12087309 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,04971563 0,12074545 ! endocrine system development GO:0035270 83 47 1,000 0,04971563 0,12061808 ! covalent chromatin modification GO:0016569 75 47 1,000 0,04971563 0,12049098 ! positive regulation of cyclase activity GO:0031281 87 47 1,000 0,04971563 0,12036415 ! response to temperature stimulus GO:0009266 62 48 1,000 0,051625 0,12485541 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,051625 0,12472426 ! regulation of DNA replication GO:0006275 75 48 1,000 0,051625 0,12459339 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,051625 0,12446279 ! positive regulation of lyase activity GO:0051349 88 48 1,000 0,051625 0,12433246 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05206334 0,125257 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05206334 0,12512611 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05206334 0,1249955 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05206334 0,12486516 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05206334 0,12473509 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05206334 0,1246053 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05206334 0,12447577 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05206334 0,12434651 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05206334 0,12421752 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05206334 0,1240888 ! reproductive behavior GO:0019098 12 7 0,000 0,05206334 0,12396034 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05206334 0,12383215 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,05206334 0,12370423 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05206334 0,12357656 ! oligopeptide transport GO:0006857 11 7 0,000 0,05206334 0,12344917 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05206334 0,12332203 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05206334 0,12319516 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05206334 0,12306854 ! RNA methylation GO:0001510 11 7 0,000 0,05206334 0,12294219 ! pericardium development GO:0060039 8 7 0,000 0,05206334 0,12281609 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05206334 0,12269026 ! fibril organization GO:0043206 13 7 0,000 0,05206334 0,12256468 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05206334 0,12243936 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05206334 0,12231429 ! lipoprotein transport GO:0042953 9 7 0,000 0,05206334 0,12218948 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05206334 0,12206492 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05206334 0,12194062 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05206334 0,12181657 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05206334 0,12169278 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05206334 0,12156923 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05206334 0,12144593 ! chemosensory behavior GO:0007635 9 7 0,000 0,05206334 0,12132289 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05206334 0,12120009 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05206334 0,12107754 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05206334 0,12095524 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05206334 0,12083319 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05206334 0,12071138 ! reflex GO:0060004 12 7 0,000 0,05206334 0,12058982 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05206334 0,1204685 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05206334 0,12034743 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05206334 0,1202266 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05206334 0,12010601 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05206334 0,11998566 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05206334 0,11986556 ! spinal cord patterning GO:0021511 7 7 0,000 0,05206334 0,11974569 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05206334 0,11962606 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05206334 0,11950668 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05206334 0,11938753 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05206334 0,11926862 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05206334 0,11914994 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05206334 0,1190315 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05206334 0,1189133 ! endosome organization GO:0007032 10 7 0,000 0,05206334 0,11879533 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05206334 0,11867759 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05206334 0,11856009 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05206334 0,11844282 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05206334 0,11832578 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05206334 0,11820897 GO:0021952|central nervous system projection neuron axonogenesis, ! galactose metabolic process GO:0006012 10 7 0,000 0,05206334 0,1180924 ! vesicle fusion GO:0006906 15 7 0,000 0,05206334 0,11797605 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05206334 0,11785993 GO:0045851|pH reduction, ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05206334 0,11774404 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05206334 0,11762838 ! retinol metabolic process GO:0042572 9 7 0,000 0,05206334 0,11751294 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05206334 0,11739774 ! rRNA modification GO:0000154 12 7 0,000 0,05206334 0,11728275 ! protein heterooligomerization GO:0051291 10 7 0,000 0,05206334 0,11716799 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05206334 0,11705346 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,05206334 0,11693915 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05206334 0,11682506 ! intermediate filament organization GO:0045109 11 7 0,000 0,05206334 0,1167112 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05206334 0,11659756 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05206334 0,11648414 ! fibrinolysis GO:0042730 9 7 0,000 0,05206334 0,11637093 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,05206334 0,11625795 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05206334 0,11614519 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05206334 0,11603265 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05206334 0,11592032 ! response to tropane GO:0014073 13 7 0,000 0,05206334 0,11580821 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05206334 0,11569632 ! melanosome localization GO:0032400 10 7 0,000 0,05206334 0,11558464 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05206334 0,11547318 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05206334 0,11536194 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05206334 0,11525091 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05206334 0,11514009 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05206334 0,11502948 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05206334 0,11491909 ! mast cell activation GO:0045576 9 7 0,000 0,05206334 0,11480891 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05206334 0,11469894 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05206334 0,11458918 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05206334 0,11447963 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05206334 0,11437029 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05206334 0,11426116 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05206334 0,11415223 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05206334 0,11404352 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05206334 0,11393501 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05206334 0,1138267 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05206334 0,1137186 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05206334 0,11361071 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05206334 0,11350302 ! response to tumor cell GO:0002347 12 7 0,000 0,05206334 0,11339554 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05206334 0,11328826 ! neuroblast proliferation GO:0007405 13 7 0,000 0,05206334 0,11318118 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05206334 0,11307431 ! diuresis GO:0030146 12 7 0,000 0,05206334 0,11296763 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05206334 0,11286116 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05206334 0,11275489 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05206334 0,11264882 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05206334 0,11254294 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05206334 0,11243727 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05206334 0,11233179 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05206334 0,11222651 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05206334 0,11212143 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05206334 0,11201655 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05206334 0,11191186 ! lymph node development GO:0048535 9 7 0,000 0,05206334 0,11180737 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05206334 0,11170307 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05206334 0,11159897 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05206334 0,11149506 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05206334 0,11139134 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05206334 0,11128782 ! ATP catabolic process GO:0006200 10 7 0,000 0,05206334 0,11118449 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05206334 0,11108135 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05206334 0,1109784 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05206334 0,11087564 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05206334 0,11077307 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05206334 0,11067069 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05206334 0,1105685 ! muscle adaptation GO:0043500 12 7 0,000 0,05206334 0,1104665 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05206334 0,11036469 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05206334 0,11026307 ! retina homeostasis GO:0001895 9 7 0,000 0,05206334 0,11016163 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05206334 0,11006038 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05206334 0,10995931 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05206334 0,10985843 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05206334 0,10975774 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05206334 0,10965723 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05206334 0,1095569 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05206334 0,10945676 ! membrane fusion GO:0006944 80 50 1,000 0,05552116 0,11661979 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,05552116 0,11651338 ! lipid modification GO:0030258 73 50 1,000 0,05552116 0,11640717 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,05750696 0,12046084 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,05750696 0,12035123 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05927797 0,12394484 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05927797 0,12383227 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05927797 0,1237199 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,05927797 0,12360773 ! associative learning GO:0008306 15 8 0,000 0,05927797 0,12349577 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05927797 0,12338401 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05927797 0,12327245 ! phosphate transport GO:0006817 10 8 0,000 0,05927797 0,12316109 ! N-glycan processing GO:0006491 12 8 0,000 0,05927797 0,12304994 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05927797 0,12293898 ! UTP metabolic process GO:0046051 8 8 0,000 0,05927797 0,12282822 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05927797 0,12271767 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05927797 0,12260731 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,05927797 0,12249715 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05927797 0,12238719 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05927797 0,12227742 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05927797 0,12216786 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05927797 0,12205849 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05927797 0,12194931 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05927797 0,12184033 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05927797 0,12173154 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05927797 0,12162295 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05927797 0,12151455 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05927797 0,12140635 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05927797 0,12129834 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05927797 0,12119051 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05927797 0,12108289 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05927797 0,12097545 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05927797 0,1208682 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05927797 0,12076114 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05927797 0,12065427 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05927797 0,12054759 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05927797 0,1204411 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05927797 0,1203348 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05927797 0,12022868 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05927797 0,12012276 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,05927797 0,12001701 ! macrophage activation GO:0042116 12 8 0,000 0,05927797 0,11991146 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05927797 0,11980609 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05927797 0,1197009 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,05927797 0,1195959 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05927797 0,11949109 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05927797 0,11938645 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05927797 0,119282 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05927797 0,11917773 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05927797 0,11907365 ! ruffle organization GO:0031529 11 8 0,000 0,05927797 0,11896975 ! osteoblast development GO:0002076 13 8 0,000 0,05927797 0,11886602 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05927797 0,11876248 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05927797 0,11865912 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05927797 0,11855594 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05927797 0,11845294 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05927797 0,11835011 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05927797 0,11824747 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05927797 0,118145 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05927797 0,11804271 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05927797 0,1179406 ! segment specification GO:0007379 10 8 0,000 0,05927797 0,11783866 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05927797 0,1177369 ! cellular extravasation GO:0045123 11 8 0,000 0,05927797 0,11763531 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05927797 0,1175339 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05927797 0,11743267 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05927797 0,11733161 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05927797 0,11723072 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05927797 0,11713001 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05927797 0,11702947 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05927797 0,1169291 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05927797 0,1168289 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05927797 0,11672888 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05927797 0,11662902 ! icosanoid secretion GO:0032309 12 8 0,000 0,05927797 0,11652934 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05927797 0,11642983 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05927797 0,11633049 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05927797 0,11623131 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05927797 0,11613231 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05927797 0,11603347 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05927797 0,1159348 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05927797 0,1158363 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05927797 0,11573797 ! sterol catabolic process GO:0016127 9 8 0,000 0,05927797 0,1156398 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05927797 0,1155418 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05927797 0,11544397 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05927797 0,1153463 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05927797 0,1152488 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05927797 0,11515146 ! prophase GO:0051324 11 8 0,000 0,05927797 0,11505429 ! S phase GO:0051320 8 8 0,000 0,05927797 0,11495728 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05927797 0,11486043 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05927797 0,11476374 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05927797 0,11466722 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05927797 0,11457086 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05927797 0,11447467 ! hormone catabolic process GO:0042447 13 8 0,000 0,05927797 0,11437863 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05927797 0,11428276 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05927797 0,11418704 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05927797 0,11409149 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05927797 0,11399609 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05927797 0,11390086 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05927797 0,11380578 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05927797 0,11371087 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05927797 0,11361611 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05927797 0,11352151 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05927797 0,11342706 ! regulation of embryonic development GO:0045995 16 8 0,000 0,05927797 0,11333278 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05927797 0,11323865 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05927797 0,11314467 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05927797 0,11305085 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,05951725 0,11341315 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,06155155 0,11719253 ! cell projection assembly GO:0030031 76 53 1,000 0,06155155 0,11709559 ! detection of external stimulus GO:0009581 66 54 1,000 0,06360939 0,12091042 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,06360939 0,12081058 ! regulation of mitosis GO:0007088 84 54 1,000 0,06360939 0,1207109 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,06360939 0,12061138 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,06360939 0,12051203 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06643809 0,12576759 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06643809 0,12566416 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06643809 0,1255609 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06643809 0,12545781 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06643809 0,1253549 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06643809 0,12525215 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06643809 0,12514956 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06643809 0,12504715 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06643809 0,1249449 ! GTP metabolic process GO:0046039 9 9 0,000 0,06643809 0,12484282 ! social behavior GO:0035176 14 9 0,000 0,06643809 0,12474091 ! regulation of histone modification GO:0031056 11 9 0,000 0,06643809 0,12463917 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06643809 0,12453759 ! response to pain GO:0048265 16 9 0,000 0,06643809 0,12443617 ! protein complex disassembly GO:0043241 17 9 0,000 0,06643809 0,12433492 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06643809 0,12423383 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06643809 0,12413291 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06643809 0,12403216 ! lung alveolus development GO:0048286 17 9 0,000 0,06643809 0,12393156 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06643809 0,12383113 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06643809 0,12373086 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06643809 0,12363076 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06643809 0,12353081 ! protein targeting to ER GO:0045047 19 9 0,000 0,06643809 0,12343103 ! endoderm development GO:0007492 12 9 0,000 0,06643809 0,12333141 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06643809 0,12323195 GO:0006688|glycosphingolipid biosynthetic process, ! arginine catabolic process GO:0006527 10 9 0,000 0,06643809 0,12313265 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06643809 0,12303351 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06643809 0,12293453 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06643809 0,1228357 ! V(D)J recombination GO:0033151 12 9 0,000 0,06643809 0,12273704 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06643809 0,12263854 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06643809 0,12254019 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06643809 0,122442 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06643809 0,12234397 ! mannose metabolic process GO:0006013 9 9 0,000 0,06643809 0,12224609 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06643809 0,12214837 ! receptor clustering GO:0043113 15 9 0,000 0,06643809 0,12205081 ! epithelial cell development GO:0002064 10 9 0,000 0,06643809 0,12195341 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06643809 0,12185615 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06643809 0,12175906 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06643809 0,12166212 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06643809 0,12156533 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06643809 0,12146869 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06643809 0,12137221 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06643809 0,12127589 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,06643809 0,12117971 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06643809 0,12108369 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06643809 0,12098782 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06643809 0,1208921 ! response to amine stimulus GO:0014075 13 9 0,000 0,06643809 0,12079654 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06643809 0,12070112 ! erythrocyte development GO:0048821 11 9 0,000 0,06643809 0,12060585 ! renal water homeostasis GO:0003091 14 9 0,000 0,06643809 0,12051074 ! postreplication repair GO:0006301 11 9 0,000 0,06643809 0,12041577 ! mRNA cleavage GO:0006379 13 9 0,000 0,06643809 0,12032096 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06643809 0,12022629 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06643809 0,12013177 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06643809 0,12003741 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06643809 0,11994318 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06643809 0,11984911 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06643809 0,11975519 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06643809 0,11966141 ! acid secretion GO:0046717 14 9 0,000 0,06643809 0,11956778 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06643809 0,11947429 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06643809 0,11938095 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06643809 0,11928776 ! purine base metabolic process GO:0006144 18 9 0,000 0,06643809 0,11919471 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06643809 0,11910181 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06643809 0,11900905 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06643809 0,11891643 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06643809 0,11882396 ! detection of calcium ion GO:0005513 13 9 0,000 0,06643809 0,11873164 ! blastocyst formation GO:0001825 12 9 0,000 0,06643809 0,11863945 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06643809 0,11854741 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06643809 0,11845552 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06643809 0,11836376 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06643809 0,11827215 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06643809 0,11818068 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06643809 0,11808935 ! prepulse inhibition GO:0060134 14 9 0,000 0,06643809 0,11799816 ! embryonic placenta development GO:0001892 12 9 0,000 0,06643809 0,11790711 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06643809 0,1178162 ! insulin secretion GO:0030073 17 9 0,000 0,06643809 0,11772544 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06643809 0,11763481 ! nucleus localization GO:0051647 15 9 0,000 0,06643809 0,11754432 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06643809 0,11745397 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,06779381 0,11975866 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,06779381 0,11966675 ! carbohydrate transport GO:0008643 74 57 1,000 0,06991947 0,12332422 ! chromosome segregation GO:0007059 83 57 1,000 0,06991947 0,12322972 ! camera-type eye development GO:0043010 88 57 1,000 0,06991947 0,12313536 ! secondary metabolic process GO:0019748 84 57 1,000 0,06991947 0,12304115 ! developmental maturation GO:0021700 75 57 1,000 0,06991947 0,12294708 ! viral reproductive process GO:0022415 87 58 1,000 0,07206682 0,12662619 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,07206682 0,12652953 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07354413 0,12902479 ! neuron fate specification GO:0048665 11 10 0,000 0,07354413 0,12892644 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07354413 0,12882825 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07354413 0,12873021 ! thyroid gland development GO:0030878 19 10 0,000 0,07354413 0,12863232 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07354413 0,12853457 ! synapsis GO:0007129 13 10 0,000 0,07354413 0,12843697 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07354413 0,12833953 ! sulfate transport GO:0008272 12 10 0,000 0,07354413 0,12824223 ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07354413 0,12814507 ! androgen metabolic process GO:0008209 13 10 0,000 0,07354413 0,12804807 ! phospholipid efflux GO:0033700 16 10 0,000 0,07354413 0,12795121 ! hippocampus development GO:0021766 19 10 0,000 0,07354413 0,12785449 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07354413 0,12775793 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07354413 0,12766151 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07354413 0,12756523 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07354413 0,1274691 ! pathogenesis GO:0009405 13 10 0,000 0,07354413 0,12737311 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07354413 0,12727727 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07354413 0,12718158 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07354413 0,12708602 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07354413 0,12699061 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,07354413 0,12689535 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07354413 0,12680022 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07354413 0,12670524 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07354413 0,1266104 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07354413 0,1265157 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07354413 0,12642115 ! response to X-ray GO:0010165 16 10 0,000 0,07354413 0,12632673 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07354413 0,12623246 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07354413 0,12613833 ! forebrain cell migration GO:0021885 17 10 0,000 0,07354413 0,12604433 ! lipid digestion GO:0044241 15 10 0,000 0,07354413 0,12595048 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07354413 0,12585677 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07354413 0,12576319 ! UV protection GO:0009650 14 10 0,000 0,07354413 0,12566976 ! entry into host cell GO:0030260 20 10 0,000 0,07354413 0,12557646 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07354413 0,12548331 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07354413 0,12539029 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,07354413 0,1252974 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07354413 0,12520466 ! regulation of organ growth GO:0046620 11 10 0,000 0,07354413 0,12511205 ! response to dsRNA GO:0043331 18 10 0,000 0,07354413 0,12501958 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07354413 0,12492725 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07354413 0,12483505 ! embryonic axis specification GO:0000578 12 10 0,000 0,07354413 0,12474299 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07354413 0,12465107 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07354413 0,12455927 ! cranial nerve development GO:0021545 12 10 0,000 0,07354413 0,12446762 ! fucose catabolic process GO:0019317 16 10 0,000 0,07354413 0,1243761 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07354413 0,12428471 ! protein sumoylation GO:0016925 12 10 0,000 0,07354413 0,12419346 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07354413 0,12410234 ! zymogen activation GO:0031638 14 10 0,000 0,07354413 0,12401136 ! salivary gland development GO:0007431 22 10 0,000 0,07354413 0,12392051 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07354413 0,12382979 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07354413 0,12373921 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07354413 0,12364875 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07354413 0,12355843 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,07354413 0,12346824 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07354413 0,12337819 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07354413 0,12328826 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07354413 0,12319847 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07354413 0,1231088 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,07354413 0,12301927 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07354413 0,12292987 ! detection of bacterium GO:0016045 10 10 0,000 0,07354413 0,12284059 ! embryonic gut development GO:0048566 11 10 0,000 0,07354413 0,12275145 ! activation of innate immune response GO:0002218 10 10 0,000 0,07354413 0,12266243 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07354413 0,12257355 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07354413 0,12248479 ! developmental induction GO:0031128 13 10 0,000 0,07354413 0,12239616 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07354413 0,12230766 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,07354413 0,12221929 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07354413 0,12213104 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07354413 0,12204293 ! lung development GO:0030324 94 59 1,000 0,07423541 0,12310126 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,07423541 0,12301257 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,07642481 0,12654936 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,07642481 0,12645832 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,07642481 0,12636741 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,07863457 0,12992782 ! rRNA transcription GO:0009303 17 11 0,000 0,08059648 0,13307387 ! respiratory burst GO:0045730 14 11 0,000 0,08059648 0,13297841 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,08059648 0,13288308 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,08059648 0,13278789 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,08059648 0,13269284 ! virus-host interaction GO:0019048 17 11 0,000 0,08059648 0,13259792 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,08059648 0,13250314 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,08059648 0,1324085 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08059648 0,13231399 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,08059648 0,13221961 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,08059648 0,13212537 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,08059648 0,13203127 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,08059648 0,13193729 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,08059648 0,13184345 ! bone resorption GO:0045453 16 11 0,000 0,08059648 0,13174975 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08059648 0,13165618 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08059648 0,13156274 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,08059648 0,13146943 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,08059648 0,13137626 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,08059648 0,13128321 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,08059648 0,1311903 ! plasma membrane organization GO:0007009 18 11 0,000 0,08059648 0,13109752 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08059648 0,13100487 ! mitotic spindle organization GO:0007052 15 11 0,000 0,08059648 0,13091236 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,08059648 0,13081997 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,08059648 0,13072771 ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08059648 0,13063559 ! adult heart development GO:0007512 11 11 0,000 0,08059648 0,13054359 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,08059648 0,13045172 ! temperature homeostasis GO:0001659 16 11 0,000 0,08059648 0,13035998 ! L-glutamate transport GO:0015813 16 11 0,000 0,08059648 0,13026837 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,08059648 0,13017689 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08059648 0,13008554 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08059648 0,12999432 ! stem cell development GO:0048864 29 11 0,000 0,08059648 0,12990322 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08059648 0,12981225 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08059648 0,12972141 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08059648 0,1296307 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,08059648 0,12954011 ! vasoconstriction GO:0042310 15 11 0,000 0,08059648 0,12944965 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08059648 0,12935931 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08059648 0,12926911 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08059648 0,12917902 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,08059648 0,12908906 ! ribosome assembly GO:0042255 13 11 0,000 0,08059648 0,12899923 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,08059648 0,12890952 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,08059648 0,12881994 ! chromatin silencing GO:0006342 19 11 0,000 0,08059648 0,12873048 ! nucleosome positioning GO:0016584 13 11 0,000 0,08059648 0,12864115 ! regulation of isotype switching GO:0045191 19 11 0,000 0,08059648 0,12855194 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,08059648 0,12846285 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,08059648 0,12837389 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08059648 0,12828505 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,08059648 0,12819633 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08059648 0,12810774 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,08059648 0,12801927 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08059648 0,12793092 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08059648 0,12784269 ! male genitalia development GO:0030539 13 11 0,000 0,08059648 0,12775458 ! cholesterol efflux GO:0033344 19 11 0,000 0,08059648 0,1276666 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08059648 0,12757873 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,08059648 0,12749099 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,08059648 0,12740337 GO:0010829|negative regulation of glucose transport, ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08059648 0,12731586 ! defense response to fungus GO:0050832 12 11 0,000 0,08059648 0,12722848 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08059648 0,12714122 ! lysogeny GO:0030069 18 11 0,000 0,08059648 0,12705408 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08059648 0,12696705 ! acrosome reaction GO:0007340 13 11 0,000 0,08059648 0,12688015 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,08059648 0,12679336 ! respiratory tube development GO:0030323 99 62 1,000 0,08086427 0,1271277 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,08086427 0,12704087 ! viral reproduction GO:0016032 92 63 1,000 0,08311348 0,13048533 ! regulation of lipase activity GO:0060191 109 63 1,000 0,08311348 0,13039632 ! appendage morphogenesis GO:0035107 93 64 1,000 0,08538178 0,13386373 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 1,000 0,08538178 0,13377255 ! reproductive cellular process GO:0048610 14 12 0,000 0,08759554 0,13714755 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08759554 0,13705425 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08759554 0,13696108 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,08759554 0,13686803 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08759554 0,13677512 ! non-recombinational repair GO:0000726 19 12 0,000 0,08759554 0,13668232 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08759554 0,13658966 ! peroxisomal transport GO:0043574 21 12 0,000 0,08759554 0,13649712 ! cartilage condensation GO:0001502 18 12 0,000 0,08759554 0,1364047 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08759554 0,13631241 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08759554 0,13622025 ! heart looping GO:0001947 15 12 0,000 0,08759554 0,13612821 ! palate development GO:0060021 15 12 0,000 0,08759554 0,13603629 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08759554 0,1359445 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08759554 0,13585283 ! arginine metabolic process GO:0006525 13 12 0,000 0,08759554 0,13576128 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08759554 0,13566986 ! methionine metabolic process GO:0006555 13 12 0,000 0,08759554 0,13557856 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08759554 0,13548739 ! Golgi organization GO:0007030 18 12 0,000 0,08759554 0,13539634 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,08759554 0,1353054 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08759554 0,1352146 ! monoamine transport GO:0015844 13 12 0,000 0,08759554 0,13512391 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08759554 0,13503334 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,08759554 0,1349429 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08759554 0,13485257 ! L-amino acid transport GO:0015807 20 12 0,000 0,08759554 0,13476237 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08759554 0,13467229 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08759554 0,13458233 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08759554 0,13449249 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08759554 0,13440277 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08759554 0,13431316 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08759554 0,13422368 ! cerebellum development GO:0021549 13 12 0,000 0,08759554 0,13413432 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08759554 0,13404507 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08759554 0,13395595 ! histone methylation GO:0016571 15 12 0,000 0,08759554 0,13386694 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08759554 0,13377805 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08759554 0,13368928 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08759554 0,13360063 ! intestinal absorption GO:0050892 19 12 0,000 0,08759554 0,13351209 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08759554 0,13342367 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08759554 0,13333537 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08759554 0,13324719 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08759554 0,13315912 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08759554 0,13307117 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08759554 0,13298333 ! microspike assembly GO:0030035 23 12 0,000 0,08759554 0,13289561 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08759554 0,13280801 ! response to cold GO:0009409 14 12 0,000 0,08759554 0,13272052 ! appendage development GO:0048736 94 65 1,000 0,08766875 0,132744 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 1,000 0,08766875 0,13265667 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,08766875 0,13256945 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,08766875 0,13248235 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,08766875 0,13239536 ! positive regulation of T cell activation GO:0050870 94 65 1,000 0,08766875 0,13230849 ! protein oligomerization GO:0051259 100 65 1,000 0,08766875 0,13222173 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,08997399 0,13560956 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,09229709 0,13901984 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,09229709 0,13892886 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09454172 0,1422145 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09454172 0,14212155 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09454172 0,14202872 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,09454172 0,14193601 ! water transport GO:0006833 17 13 0,000 0,09454172 0,14184342 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09454172 0,14175095 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09454172 0,14165861 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09454172 0,14156638 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09454172 0,14147428 ! organelle fusion GO:0048284 28 13 0,000 0,09454172 0,14138229 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09454172 0,14129043 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09454172 0,14119868 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,09454172 0,14110705 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09454172 0,14101554 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09454172 0,14092415 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09454172 0,14083288 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,09454172 0,14074172 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09454172 0,14065069 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09454172 0,14055977 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09454172 0,14046897 ! NAD metabolic process GO:0019674 21 13 0,000 0,09454172 0,14037829 ! exocrine system development GO:0035272 27 13 0,000 0,09454172 0,14028772 ! bone mineralization GO:0030282 15 13 0,000 0,09454172 0,14019727 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09454172 0,14010694 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09454172 0,14001672 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09454172 0,13992662 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09454172 0,13983663 ! genitalia development GO:0048806 15 13 0,000 0,09454172 0,13974676 ! regulation of cellular pH GO:0030641 20 13 0,000 0,09454172 0,13965701 ! tissue regeneration GO:0042246 21 13 0,000 0,09454172 0,13956737 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09454172 0,13947785 ! cofactor transport GO:0051181 19 13 0,000 0,09454172 0,13938844 ! NADP metabolic process GO:0006739 18 13 0,000 0,09454172 0,13929914 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09454172 0,13920996 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09454172 0,1391209 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09454172 0,13903195 ! gas transport GO:0015669 18 13 0,000 0,09454172 0,13894311 ! regulation of RNA stability GO:0043487 28 13 0,000 0,09454172 0,13885438 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09454172 0,13876577 ! regulation of axon extension GO:0030516 23 13 0,000 0,09454172 0,13867727 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09454172 0,13858889 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09454172 0,13850061 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09454172 0,13841245 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09454172 0,1383244 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09454172 0,13823647 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,09463764 0,1382888 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,09463764 0,138201 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,09699526 0,141554 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,09699526 0,14146424 ! humoral immune response GO:0006959 86 70 1,000 0,09936955 0,14483522 ! eye development GO:0001654 111 70 1,000 0,09936955 0,14474349 ! superoxide anion generation GO:0042554 18 14 0,000 0,10143542 0,14765915 ! regulation of S phase GO:0033261 18 14 0,000 0,10143542 0,14756576 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,10143542 0,14747248 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,10143542 0,14737932 ! inositol metabolic process GO:0006020 20 14 0,000 0,10143542 0,14728628 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,10143542 0,14719335 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,10143542 0,14710054 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,10143542 0,14700785 ! gene silencing by RNA GO:0031047 20 14 0,000 0,10143542 0,14691528 ! response to cAMP GO:0051591 19 14 0,000 0,10143542 0,14682282 ! limbic system development GO:0021761 25 14 0,000 0,10143542 0,14673048 ! startle response GO:0001964 21 14 0,000 0,10143542 0,14663825 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,10143542 0,14654614 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,10143542 0,14645415 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,10143542 0,14636227 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,10143542 0,14627051 ! glycine metabolic process GO:0006544 22 14 0,000 0,10143542 0,14617886 ! pituitary gland development GO:0021983 23 14 0,000 0,10143542 0,14608733 ! cellular response to starvation GO:0009267 21 14 0,000 0,10143542 0,14599591 ! lysosomal transport GO:0007041 20 14 0,000 0,10143542 0,1459046 ! regulation of heart rate GO:0002027 23 14 0,000 0,10143542 0,14581341 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,10143542 0,14572234 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,10143542 0,14563137 ! embryo implantation GO:0007566 27 14 0,000 0,10143542 0,14554053 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,10143542 0,14544979 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,10143542 0,14535917 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,10143542 0,14526866 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! axon cargo transport GO:0008088 27 14 0,000 0,10143542 0,14517826 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,10143542 0,14508797 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,10143542 0,1449978 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10143542 0,14490774 ! mRNA splice site selection GO:0006376 26 14 0,000 0,10143542 0,14481779 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,10143542 0,14472795 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,10143542 0,14463823 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,10143542 0,14454861 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,10143542 0,14445911 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,10143542 0,14436972 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,10143542 0,14428043 ! muscle maintenance GO:0046716 19 14 0,000 0,10143542 0,14419126 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,10143542 0,1441022 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,10143542 0,14401325 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,10143542 0,14392441 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,10143542 0,14383567 ! cell killing GO:0001906 20 14 0,000 0,10143542 0,14374705 ! cilium assembly GO:0042384 20 14 0,000 0,10143542 0,14365854 ! peptide hormone secretion GO:0030072 23 14 0,000 0,10143542 0,14357013 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,10416662 0,14734516 ! negative regulation of transport GO:0051051 116 73 1,000 0,10658864 0,15067847 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,10658864 0,15058591 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10827702 0,15287731 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10827702 0,15278352 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10827702 0,15268985 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10827702 0,15259629 ! skin development GO:0043588 25 15 0,000 0,10827702 0,15250284 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10827702 0,15240951 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10827702 0,1523163 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10827702 0,15222319 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10827702 0,1521302 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10827702 0,15203733 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10827702 0,15194457 ! adult walking behavior GO:0007628 25 15 0,000 0,10827702 0,15185192 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10827702 0,15175938 ! myoblast differentiation GO:0045445 27 15 0,000 0,10827702 0,15166696 ! centrosome cycle GO:0007098 16 15 0,000 0,10827702 0,15157465 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10827702 0,15148245 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10827702 0,15139036 ! response to osmotic stress GO:0006970 22 15 0,000 0,10827702 0,15129839 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10827702 0,15120652 ! DNA integration GO:0015074 22 15 0,000 0,10827702 0,15111477 ! peptide secretion GO:0002790 27 15 0,000 0,10827702 0,15102313 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10827702 0,1509316 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10827702 0,15084018 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10827702 0,15074888 ! neuron recognition GO:0008038 22 15 0,000 0,10827702 0,15065768 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10827702 0,15056659 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,10827702 0,15047562 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10827702 0,15038475 ! biomineral formation GO:0031214 18 15 0,000 0,10827702 0,15029399 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10827702 0,15020334 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10827702 0,15011281 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10827702 0,15002238 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10827702 0,14993206 ! organic cation transport GO:0015695 19 15 0,000 0,10827702 0,14984184 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10827702 0,14975174 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10827702 0,14966175 ! peptide hormone processing GO:0016486 19 15 0,000 0,10827702 0,14957186 ! protein import into nucleus GO:0006606 118 74 1,000 0,10902582 0,15051584 ! response to nutrient GO:0007584 104 75 1,000 0,11147779 0,15380859 ! nuclear import GO:0051170 121 75 1,000 0,11147779 0,15371638 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,1139442 0,15702316 ! protein secretion GO:0009306 27 16 0,000 0,11506692 0,1584754 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,11506692 0,15838056 ! hormone secretion GO:0046879 25 16 0,000 0,11506692 0,15828583 ! bone remodeling GO:0046849 24 16 0,000 0,11506692 0,15819122 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11506692 0,15809672 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11506692 0,15800234 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11506692 0,15790806 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11506692 0,1578139 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11506692 0,15771985 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11506692 0,15762591 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11506692 0,15753209 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11506692 0,15743838 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11506692 0,15734477 ! protein export from nucleus GO:0006611 24 16 0,000 0,11506692 0,15725128 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11506692 0,1571579 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11506692 0,15706464 ! DNA replication initiation GO:0006270 25 16 0,000 0,11506692 0,15697148 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11506692 0,15687843 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11506692 0,15678549 ! diencephalon development GO:0021536 25 16 0,000 0,11506692 0,15669266 ! neural crest cell migration GO:0001755 24 16 0,000 0,11506692 0,15659995 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,11506692 0,15650734 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11506692 0,15641484 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11506692 0,15632245 ! steroid catabolic process GO:0006706 22 16 0,000 0,11506692 0,15623017 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11506692 0,156138 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,11506692 0,15604594 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11506692 0,15595398 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11506692 0,15586214 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11506692 0,1557704 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11506692 0,15567877 ! nerve development GO:0021675 18 16 0,000 0,11506692 0,15558725 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11506692 0,15549583 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11506692 0,15540453 ! negative regulation of translation GO:0017148 22 16 0,000 0,11506692 0,15531333 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,11642468 0,15705382 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,11642468 0,15696176 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,11642468 0,15686981 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,11891889 0,16013667 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,12142647 0,16341771 ! regulation of lyase activity GO:0051339 133 79 1,000 0,12142647 0,16332215 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,1218055 0,16373621 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,1218055 0,16364057 ! negative regulation of defense response GO:0031348 19 17 0,000 0,1218055 0,16354504 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,1218055 0,16344962 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,1218055 0,16335432 ! glycerol metabolic process GO:0006071 20 17 0,000 0,1218055 0,16325912 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,1218055 0,16316404 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,1218055 0,16306906 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,1218055 0,1629742 ! signal complex assembly GO:0007172 29 17 0,000 0,1218055 0,16287945 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,1218055 0,16278481 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,1218055 0,16269027 ! memory GO:0007613 25 17 0,000 0,1218055 0,16259585 ! keratinization GO:0031424 17 17 0,000 0,1218055 0,16250154 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,1218055 0,16240734 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,1218055 0,16231324 ! retinoid metabolic process GO:0001523 22 17 0,000 0,1218055 0,16221925 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,1218055 0,16212538 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,1218055 0,16203161 ! vacuolar transport GO:0007034 24 17 0,000 0,1218055 0,16193795 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,1218055 0,1618444 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,1218055 0,16175095 ! heme metabolic process GO:0042168 27 17 0,000 0,1218055 0,16165762 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,1218055 0,16156439 ! body fluid secretion GO:0007589 27 17 0,000 0,1218055 0,16147127 ! stem cell differentiation GO:0048863 36 17 0,000 0,1218055 0,16137826 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,1218055 0,16128535 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,1218055 0,16119255 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,1218055 0,16109986 ! sensory perception of pain GO:0019233 23 17 0,000 0,1218055 0,16100727 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,1218055 0,16091479 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,1218055 0,16082242 ! synaptogenesis GO:0007416 24 17 0,000 0,1218055 0,16073015 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,1218055 0,16063799 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,1218055 0,16054593 ! cell-cell junction organization GO:0045216 25 17 0,000 0,1218055 0,16045398 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,1218055 0,16036214 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,1218055 0,1602704 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,1218055 0,16017876 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,1218055 0,16008723 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,1218055 0,1599958 ! chromatin assembly GO:0031497 102 80 1,000 0,12394708 0,16271591 GO:0006334|nucleosome assembly, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,12394708 0,16262309 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,12394708 0,16253037 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,12394708 0,16243776 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,12648038 0,16566336 ! regulation of neurological system process GO:0031644 122 81 1,000 0,12648038 0,16556908 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,12849315 0,16810822 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,12849315 0,16801265 ! positive regulation of translation GO:0045727 28 18 0,000 0,12849315 0,16791719 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12849315 0,16782184 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12849315 0,16772659 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12849315 0,16763146 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,12849315 0,16753643 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12849315 0,1674415 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12849315 0,16734669 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12849315 0,16725198 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12849315 0,16715738 ! axis specification GO:0009798 26 18 0,000 0,12849315 0,16706289 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12849315 0,16696851 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12849315 0,16687423 ! pancreas development GO:0031016 26 18 0,000 0,12849315 0,16678005 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12849315 0,16668599 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12849315 0,16659203 ! response to retinoic acid GO:0032526 25 18 0,000 0,12849315 0,16649817 ! pigmentation during development GO:0048066 31 18 0,000 0,12849315 0,16640442 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12849315 0,16631078 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,12849315 0,16621724 ! fucose metabolic process GO:0006004 26 18 0,000 0,12849315 0,16612381 ! response to fungus GO:0009620 19 18 0,000 0,12849315 0,16603048 ! peptide cross-linking GO:0018149 31 18 0,000 0,12849315 0,16593726 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12849315 0,16584414 ! heart process GO:0003015 27 18 0,000 0,12849315 0,16575113 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12849315 0,16565822 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,12849315 0,16556541 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12849315 0,16547271 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12849315 0,16538011 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12849315 0,16528762 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,12849315 0,16519522 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12849315 0,16510294 ! vitamin transport GO:0051180 24 18 0,000 0,12849315 0,16501075 ! hormone transport GO:0009914 27 18 0,000 0,12849315 0,16491867 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,12849315 0,16482669 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12849315 0,16473481 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12849315 0,16464304 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12849315 0,16455137 ! cell-cell recognition GO:0009988 20 18 0,000 0,12849315 0,1644598 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12849315 0,16436833 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12849315 0,16427696 ! regulation of glucose import GO:0046324 21 18 0,000 0,12849315 0,1641857 GO:0010827|regulation of glucose transport, ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,12849315 0,16409453 ! detection of stimulus GO:0051606 108 82 1,000 0,12902604 0,16468362 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,13158372 0,16785499 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of defense response GO:0031347 117 84 1,000 0,1341531 0,17103777 ! protein-DNA complex assembly GO:0065004 107 84 1,000 0,1341531 0,17094301 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13513026 0,1720928 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,13513026 0,17199756 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13513026 0,17190243 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13513026 0,17180741 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,13513026 0,17171249 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,13513026 0,17161767 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,13513026 0,17152296 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13513026 0,17142835 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13513026 0,17133385 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13513026 0,17123945 ! sensory perception of taste GO:0050909 23 19 0,000 0,13513026 0,17114515 ! peroxisome organization GO:0007031 29 19 0,000 0,13513026 0,17105096 ! digestive system process GO:0022600 30 19 0,000 0,13513026 0,17095688 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13513026 0,17086289 ! response to vitamin A GO:0033189 26 19 0,000 0,13513026 0,17076901 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13513026 0,17067523 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13513026 0,17058156 ! response to starvation GO:0042594 30 19 0,000 0,13513026 0,17048799 ! sex determination GO:0007530 29 19 0,000 0,13513026 0,17039452 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13513026 0,17030115 ! cytolysis GO:0019835 20 19 0,000 0,13513026 0,17020789 ! vasodilation GO:0042311 33 19 0,000 0,13513026 0,17011472 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13513026 0,17002166 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13513026 0,1699287 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13513026 0,16983585 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,13513026 0,16974309 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13513026 0,16965044 ! sarcomere organization GO:0045214 23 19 0,000 0,13513026 0,16955788 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,13513026 0,16946543 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13513026 0,16937308 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13513026 0,16928083 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13513026 0,16918868 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,13513026 0,16909663 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,13513026 0,16900468 ! protein stabilization GO:0050821 26 19 0,000 0,13513026 0,16891283 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,13673386 0,17082449 ! rRNA metabolic process GO:0016072 107 85 1,000 0,13673386 0,17073175 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,13673386 0,17063911 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,13673386 0,17054657 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,13673386 0,17045414 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,13932568 0,17359104 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,1417172 0,17647512 ! iron ion transport GO:0006826 37 20 0,000 0,1417172 0,17637963 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,1417172 0,17628424 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,1417172 0,17618895 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,1417172 0,17609376 ! response to vitamin GO:0033273 29 20 0,000 0,1417172 0,17599868 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,1417172 0,1759037 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,1417172 0,17580882 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,1417172 0,17571404 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,1417172 0,17561937 ! chromosome condensation GO:0030261 31 20 0,000 0,1417172 0,1755248 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,1417172 0,17543033 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,1417172 0,17533596 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,1417172 0,1752417 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,1417172 0,17514753 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,1417172 0,17505347 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,1417172 0,1749595 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,1417172 0,17486564 ! collagen catabolic process GO:0030574 25 20 0,000 0,1417172 0,17477188 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,1417172 0,17467822 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,1417172 0,17458466 ! alditol metabolic process GO:0019400 24 20 0,000 0,1417172 0,1744912 ! nucleosome organization GO:0034728 114 87 1,000 0,14192824 0,17465755 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,14454124 0,177778 ! protein processing GO:0016485 114 88 1,000 0,14454124 0,17768298 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,14716437 0,18081092 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,14825434 0,18205285 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,14825434 0,1819557 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14825434 0,18185866 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14825434 0,18176172 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,14825434 0,18166488 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14825434 0,18156815 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14825434 0,18147152 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14825434 0,18137499 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,14825434 0,18127857 ! vesicle docking GO:0048278 27 21 0,000 0,14825434 0,18118224 ! phototransduction GO:0007602 25 21 0,000 0,14825434 0,18108603 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14825434 0,18098991 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14825434 0,18089389 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14825434 0,18079798 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,14825434 0,18070216 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,14825434 0,18060645 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14825434 0,18051084 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,14825434 0,18041534 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14825434 0,18031993 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14825434 0,18022462 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14825434 0,18012942 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,14825434 0,18003431 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14825434 0,17993931 ! fatty acid transport GO:0015908 30 21 0,000 0,14825434 0,1798444 ! immunoglobulin production GO:0002377 33 21 0,000 0,14825434 0,1797496 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,14825434 0,17965489 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14825434 0,17956029 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,14825434 0,17946578 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,14825434 0,17937138 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,14825434 0,17927707 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,14825434 0,17918286 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14825434 0,17908875 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14825434 0,17899474 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14825434 0,17890083 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14825434 0,17880702 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14825434 0,1787133 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14825434 0,17861969 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,15474207 0,18633861 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,15474207 0,18624111 ! viral genome replication GO:0019079 29 22 0,000 0,15474207 0,1861437 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,15474207 0,18604639 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,15474207 0,18594919 ! leukocyte adhesion GO:0007159 38 22 0,000 0,15474207 0,18585209 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,15474207 0,18575509 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,15474207 0,18565819 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,15474207 0,18556139 ! vasculogenesis GO:0001570 33 22 0,000 0,15474207 0,1854647 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,15474207 0,1853681 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,15474207 0,18527161 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,15474207 0,18517521 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,15474207 0,18507891 ! lysosome organization GO:0007040 37 22 0,000 0,15474207 0,18498272 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,15474207 0,18488663 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,15474207 0,18479063 ! regulation of behavior GO:0050795 38 22 0,000 0,15474207 0,18469473 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,15474207 0,18459894 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,15474207 0,18450324 ! membrane depolarization GO:0051899 35 22 0,000 0,15474207 0,18440764 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,15474207 0,18431215 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,15474207 0,18421675 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,15474207 0,18412145 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,15474207 0,18402624 ! blastocyst development GO:0001824 37 22 0,000 0,15474207 0,18393114 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,15474207 0,18383613 ! protein tetramerization GO:0051262 39 22 0,000 0,15474207 0,18374123 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,15509152 0,18406115 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,15775219 0,18712224 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,15775219 0,18702579 ! neuron fate commitment GO:0048663 32 23 0,000 0,16118074 0,19099212 ! embryonic pattern specification GO:0009880 31 23 0,000 0,16118074 0,19089378 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,16118074 0,19079553 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,16118074 0,19069738 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,16118074 0,19059934 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,16118074 0,19050139 ! interaction with host GO:0051701 37 23 0,000 0,16118074 0,19040355 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,16118074 0,19030581 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,16118074 0,19020816 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,16118074 0,19011062 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,16118074 0,19001318 ! cell fate determination GO:0001709 45 23 0,000 0,16118074 0,18991584 ! pentose metabolic process GO:0019321 31 23 0,000 0,16118074 0,18981859 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,16118074 0,18972145 ! spermatid development GO:0007286 33 23 0,000 0,16118074 0,1896244 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,16118074 0,18952746 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,16118074 0,18943061 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,16118074 0,18933387 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,16118074 0,18923722 ! telomere organization GO:0032200 32 23 0,000 0,16118074 0,18914067 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,16118074 0,18904422 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,16118074 0,18894787 ! regulation of amine transport GO:0051952 38 23 0,000 0,16118074 0,18885161 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,165785 0,1941474 ! in utero embryonic development GO:0001701 147 96 1,000 0,165785 0,1940486 ! protein maturation GO:0051604 129 96 1,000 0,165785 0,1939499 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,16757074 0,19593935 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,16757074 0,19583979 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,16757074 0,19574033 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,16757074 0,19564097 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16757074 0,19554171 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,16757074 0,19544255 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16757074 0,19534349 ! sperm motility GO:0030317 27 24 0,000 0,16757074 0,19524453 ! vacuole organization GO:0007033 39 24 0,000 0,16757074 0,19514567 ! receptor metabolic process GO:0043112 37 24 0,000 0,16757074 0,19504692 ! neural crest cell development GO:0014032 39 24 0,000 0,16757074 0,19494826 GO:0014033|neural crest cell differentiation, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,16757074 0,1948497 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,16757074 0,19475124 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,16757074 0,19465288 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,16757074 0,19455462 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,16757074 0,19445646 ! protein import GO:0017038 156 99 1,000 0,17388822 0,20168579 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,17388822 0,20158413 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,17391242 0,20151062 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17391242 0,20140915 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17391242 0,20130779 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17391242 0,20120653 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,17391242 0,20110537 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,17391242 0,20100431 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17391242 0,20090335 ! peptide transport GO:0015833 43 25 0,000 0,17391242 0,2008025 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,17391242 0,20070174 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,17391242 0,20060109 ! phospholipid transport GO:0015914 35 25 0,000 0,17391242 0,20050054 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,17391242 0,20040009 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,17391242 0,20029974 ! detection of light stimulus GO:0009583 30 25 0,000 0,17391242 0,20019949 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,17660369 0,20319584 ! protein localization in organelle GO:0033365 161 100 1,000 0,17660369 0,20309424 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,18020615 0,20713351 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,18020615 0,20703005 ! translational initiation GO:0006413 43 26 0,000 0,18020615 0,20692669 ! regulation of pH GO:0006885 36 26 0,000 0,18020615 0,20682343 ! circadian rhythm GO:0007623 42 26 0,000 0,18020615 0,20672028 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,18020615 0,20661723 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,18020615 0,20651428 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,18020615 0,20641143 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,18020615 0,20630869 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,18020615 0,20620605 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,18020615 0,20610351 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,18020615 0,20600107 ! regulation of coagulation GO:0050818 39 26 0,000 0,18020615 0,20589874 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,18645229 0,21292963 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,18645229 0,21282396 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,18645229 0,21271839 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,18645229 0,21261293 ! membrane docking GO:0022406 39 27 0,000 0,18645229 0,21250757 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,18645229 0,21240231 ! catechol metabolic process GO:0009712 43 27 0,000 0,18645229 0,21229716 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,18645229 0,21219212 ! acute-phase response GO:0006953 42 27 0,000 0,18645229 0,21208718 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,18645229 0,21198234 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,18645229 0,2118776 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,18645229 0,21177297 ! lipid oxidation GO:0034440 38 27 0,000 0,18645229 0,21166845 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,18645229 0,21156402 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,18645229 0,2114597 ! gene silencing GO:0016458 41 27 0,000 0,18645229 0,21135548 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,19265119 0,21827475 ! phenol metabolic process GO:0018958 44 28 0,000 0,19265119 0,21816728 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,19265119 0,21805991 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,19265119 0,21795265 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,19265119 0,2178455 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,19265119 0,21773845 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,19265119 0,21763151 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,19265119 0,21752467 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,19265119 0,21741793 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,19265119 0,2173113 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,19265119 0,21720478 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,19265119 0,21709836 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,19265119 0,21699204 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,19265119 0,21688583 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,19265119 0,21677972 ! mesoderm formation GO:0001707 46 28 0,000 0,19265119 0,21667371 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,19265119 0,21656781 ! BMP signaling pathway GO:0030509 40 28 0,000 0,19265119 0,21646202 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,19265119 0,21635632 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,19265119 0,21625073 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,19265119 0,21614524 ! placenta development GO:0001890 37 28 0,000 0,19265119 0,21603986 ! regulation of innate immune response GO:0045088 38 29 0,000 0,19880322 0,22283012 ! protein targeting to membrane GO:0006612 53 29 0,000 0,19880322 0,22272158 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,19880322 0,22261314 ! mismatch repair GO:0006298 34 29 0,000 0,19880322 0,22250482 ! formation of primary germ layer GO:0001704 48 29 0,000 0,19880322 0,22239659 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,19880322 0,22228848 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,19880322 0,22218047 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,20490871 0,22889268 ! collagen metabolic process GO:0032963 40 30 0,000 0,20490871 0,22878157 ! organic anion transport GO:0015711 51 30 0,000 0,20490871 0,22867056 ! cholesterol transport GO:0030301 46 30 0,000 0,20490871 0,22855967 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,20490871 0,22844888 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,20490871 0,22833819 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,20490871 0,22822762 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,20490871 0,22811715 ! ceramide metabolic process GO:0006672 43 30 0,000 0,20490871 0,22800679 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,20490871 0,22789653 ! adult locomotory behavior GO:0008344 47 30 0,000 0,20490871 0,22778639 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,20490871 0,22767634 ! negative regulation of secretion GO:0051048 49 31 0,000 0,21096802 0,23429573 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,21096802 0,23418265 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,21096802 0,23406968 ! odontogenesis GO:0042476 50 31 0,000 0,21096802 0,23395682 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,21096802 0,23384407 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,21096802 0,23373143 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,21096802 0,2336189 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,21096802 0,23350647 ! cell fate specification GO:0001708 37 31 0,000 0,21096802 0,23339416 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,21096802 0,23328195 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,21096802 0,23316985 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,2169815 0,23970099 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,2169815 0,23958591 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,2169815 0,23947095 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,2169815 0,2393561 ! cytokine production GO:0001816 44 32 0,000 0,2169815 0,23924135 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,2169815 0,23912672 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,2169815 0,23901219 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,2229495 0,24546857 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,2229495 0,24535112 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,2229495 0,24523378 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,2229495 0,24511656 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,2229495 0,24499945 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,2229495 0,24488245 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,2229495 0,24476556 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,2229495 0,24464878 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,2229495 0,24453211 ! lipid homeostasis GO:0055088 55 33 0,000 0,2229495 0,24441556 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,2229495 0,24429911 ! regulation of proteolysis GO:0030162 50 33 0,000 0,2229495 0,24418278 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,2229495 0,24406656 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,2229495 0,24395045 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,2229495 0,24383445 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,22887234 0,25019315 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,22887234 0,25007429 ! feeding behavior GO:0007631 45 34 0,000 0,22887234 0,24995555 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,22887234 0,24983692 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,22887234 0,2497184 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,22887234 0,24959999 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,22887234 0,2494817 ! polyol metabolic process GO:0019751 44 34 0,000 0,22887234 0,24936352 ! aerobic respiration GO:0009060 47 34 0,000 0,22887234 0,24924545 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,22887234 0,24912749 ! embryonic organ development GO:0048568 45 34 0,000 0,22887234 0,24900964 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,22887234 0,24889191 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,23475038 0,25516345 ! Notch signaling pathway GO:0007219 56 35 0,000 0,23475038 0,25504292 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,23475038 0,25492251 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,23475038 0,2548022 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,23475038 0,25468201 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,23475038 0,25456194 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,23475038 0,25444197 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,23475038 0,25432212 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,24058394 0,26051933 ! organic ether metabolic process GO:0018904 46 36 0,000 0,24058394 0,26039674 ! tissue remodeling GO:0048771 62 36 0,000 0,24058394 0,26027425 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,24058394 0,26015189 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,24058394 0,26002964 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,24058394 0,2599075 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,24637337 0,26603697 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,24637337 0,26591213 ! ion transmembrane transport GO:0034220 56 37 0,000 0,24637337 0,2657874 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,24637337 0,2656628 ! regulation of protein secretion GO:0050708 51 37 0,000 0,24637337 0,26553831 ! amino acid activation GO:0043038 52 37 0,000 0,24637337 0,26541393 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,24637337 0,26528968 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,25211899 0,2713494 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,25211899 0,27122248 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,25211899 0,27109569 ! phagocytosis GO:0006909 60 38 0,000 0,25211899 0,27096901 ! maintenance of location in cell GO:0051651 69 38 0,000 0,25211899 0,27084244 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,25782113 0,27683875 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,25782113 0,27670957 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,25782113 0,2765805 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,25782113 0,27645156 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,25782113 0,27632274 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,26348012 0,2822563 ! regulation of tube size GO:0035150 60 40 0,000 0,26348012 0,2821249 GO:0050880|regulation of blood vessel size, ! peptide metabolic process GO:0006518 56 40 0,000 0,26348012 0,28199362 ! inner ear development GO:0048839 57 40 0,000 0,26348012 0,28186246 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,26348012 0,28173142 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! double-strand break repair GO:0006302 67 40 0,000 0,26348012 0,2816005 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,26909629 0,28746933 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,26909629 0,28733587 ! endosome transport GO:0016197 71 41 0,000 0,26909629 0,28720253 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,26909629 0,28706932 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,26909629 0,28693624 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,27466995 0,29274369 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,27466995 0,29260809 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,27466995 0,29247263 ! excretion GO:0007588 63 42 0,000 0,27466995 0,29233729 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,27466995 0,29220207 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,27466995 0,29206698 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,28020142 0,29781112 ! neuromuscular process GO:0050905 79 43 0,000 0,28020142 0,29767356 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,28020142 0,29753613 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,28569102 0,30322536 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,28569102 0,3030855 ! regulation of ion transport GO:0043269 57 44 0,000 0,28569102 0,30294576 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,28569102 0,30280615 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,28569102 0,30266668 ! regulation of translational initiation GO:0006446 64 45 0,000 0,29113907 0,30829644 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,29113907 0,30815457 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,29113907 0,30801282 ! cell recognition GO:0008037 58 45 0,000 0,29113907 0,3078712 ! cell redox homeostasis GO:0045454 63 46 0,000 0,29654588 0,31344464 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,29654588 0,31330066 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,29654588 0,31315681 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,30191176 0,31867693 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,30191176 0,31853075 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,30191176 0,3183847 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,30191176 0,31823879 ! chloride transport GO:0006821 67 48 0,000 0,30723701 0,32370367 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,30723701 0,32355546 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,30723701 0,32340738 ! gastrulation GO:0007369 73 48 0,000 0,30723701 0,32325943 ! heart morphogenesis GO:0003007 65 48 0,000 0,30723701 0,32311162 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,30723701 0,32296395 GO:0019724|B cell mediated immunity, ! regulation of endocytosis GO:0030100 63 48 0,000 0,30723701 0,32281641 ! nuclear export GO:0051168 69 48 0,000 0,30723701 0,322669 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,30723701 0,32252173 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,31252194 0,32791992 ! sensory perception of smell GO:0007608 61 49 0,000 0,31252194 0,32777039 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,31252194 0,32762099 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,31252194 0,32747173 ! RNA elongation GO:0006354 62 49 0,000 0,31252194 0,32732261 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,31252194 0,32717363 ! cartilage development GO:0051216 70 49 0,000 0,31252194 0,32702477 ! maintenance of location GO:0051235 84 49 0,000 0,31252194 0,32687606 ! regulation of actin filament length GO:0030832 72 50 0,000 0,31776685 0,3322108 ! proton transport GO:0015992 75 50 0,000 0,31776685 0,33205986 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,31776685 0,33190906 ! positive regulation of secretion GO:0051047 71 51 0,000 0,32297205 0,33719279 ! hydrogen transport GO:0006818 77 51 0,000 0,32297205 0,3370398 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,32297205 0,33688694 ! adult behavior GO:0030534 80 51 0,000 0,32297205 0,33673423 ! transition metal ion transport GO:0000041 74 52 0,000 0,32813783 0,34196511 ! regulation of cellular component size GO:0032535 74 52 0,000 0,32813783 0,34181024 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,32813783 0,3416555 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,32813783 0,34150091 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,33326449 0,34667948 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,33326449 0,34652275 ! single fertilization GO:0007338 59 53 0,000 0,33326449 0,34636616 ! amino acid transport GO:0006865 84 54 0,000 0,33835232 0,35149518 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,33835232 0,35133649 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,33835232 0,35117795 ! exocytosis GO:0006887 74 55 0,000 0,34340162 0,35625788 ! mesoderm development GO:0007498 76 55 0,000 0,34340162 0,35609726 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,34340162 0,35593678 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,34340162 0,35577645 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,34841267 0,36080555 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,35338576 0,36579084 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,35338576 0,36562629 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,35832118 0,37056597 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,36321921 0,37546256 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,36808013 0,3803164 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,36808013 0,38014562 ! regulation of heart contraction GO:0008016 91 60 0,000 0,36808013 0,379975 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,36808013 0,37980453 ! fertilization GO:0009566 68 60 0,000 0,36808013 0,37963422 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,37290423 0,38443735 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,37290423 0,38426511 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,37290423 0,38409302 ! amine catabolic process GO:0009310 90 62 0,000 0,37769177 0,38885007 ! neurotransmitter transport GO:0006836 81 62 0,000 0,37769177 0,38867609 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,37769177 0,38850226 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,37769177 0,38832859 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,38244303 0,39303797 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,38715829 0,39770615 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,38715829 0,3975286 ! adaptive immune response GO:0002250 94 64 0,000 0,38715829 0,39735121 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! defense response to bacterium GO:0042742 73 65 0,000 0,39183781 0,40197456 ! activation of immune response GO:0002253 83 65 0,000 0,39183781 0,40179535 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,39648187 0,40637625 ! antigen processing and presentation GO:0019882 96 66 0,000 0,39648187 0,40619523 ! regulation of immune effector process GO:0002697 101 66 0,000 0,39648187 0,40601438 ! acute inflammatory response GO:0002526 92 68 0,000 0,40566466 0,41523307 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,40566466 0,41504836 ! inorganic anion transport GO:0015698 93 68 0,000 0,40566466 0,41486381 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,41020391 0,41931955 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,41470876 0,42373618 ! amine transport GO:0015837 101 70 0,000 0,41470876 0,42354802 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,41470876 0,42336003 ! regulation of catabolic process GO:0009894 106 70 0,000 0,41470876 0,4231722 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,41917945 0,42754445 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,41917945 0,42735494 ! regulation of blood pressure GO:0008217 107 73 0,000 0,42801941 0,43617397 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,42801941 0,4359808 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,43238919 0,44023689 ! digestion GO:0007586 97 74 0,000 0,43238919 0,4400421 ! blood coagulation GO:0007596 116 75 0,000 0,43672583 0,44425892 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,43672583 0,44406251 ! amine biosynthetic process GO:0009309 97 76 0,000 0,44102959 0,44824041 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,4453007 0,45238146 ! protein ubiquitination GO:0016567 125 77 0,000 0,4453007 0,45218173 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,4453007 0,45198218 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,44953943 0,45608323 ! cellular respiration GO:0045333 107 79 0,000 0,453746 0,46014806 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,453746 0,45994527 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,453746 0,45974265 ! hemostasis GO:0007599 125 81 0,000 0,46206368 0,46796409 ! mRNA transport GO:0051028 121 81 0,000 0,46206368 0,46775812 ! vitamin metabolic process GO:0006766 103 81 0,000 0,46206368 0,46755234 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,47025564 0,47563235 ! sterol metabolic process GO:0016125 120 84 0,000 0,47430507 0,47951721 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,48626993 0,49139756 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,48626993 0,49118175 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,49019785 0,49493198 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,49019785 0,49471481 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,49019785 0,49449783 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,49409596 0,49821162 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,49796448 0,50189233 ! hormone metabolic process GO:0042445 121 90 0,000 0,49796448 0,5016725 ! RNA localization GO:0006403 135 91 0,000 0,50180364 0,50531891 ! ATP metabolic process GO:0046034 137 91 0,000 0,50180364 0,50509776 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,50561367 0,50871016 ! positive regulation of immune response GO:0050778 121 92 0,000 0,50561367 0,50848773 ! DNA recombination GO:0006310 146 92 0,000 0,50561367 0,50826549 ! electron transport chain GO:0022900 123 94 0,000 0,51314717 0,51561315 ! carboxylic acid transport GO:0046942 147 95 0,000 0,51687109 0,51912817 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,52056673 0,52261173 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,52056673 0,52238372 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,52056673 0,5221559 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,52423431 0,52560546 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,53148615 0,53264407 ! regulation of translation GO:0006417 151 100 0,000 0,53507082 0,536003 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,53507082 0,53576965 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,53507082 0,53553651 ! divalent metal ion transport GO:0070838 171 100 0,000 0,53507082 0,53530356 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,53507082 0,53507082