pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6410-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! interphase of mitotic cell cycle GO:0051329 209 95 9,000 2,641E-10 6,355E-07 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 7,000 2,739E-10 3,294E-07 ! interphase GO:0051325 213 98 9,000 3,606E-10 2,892E-07 ! response to UV GO:0009411 104 53 7,000 8,981E-10 5,402E-07 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 4,000 3,982E-08 1,916E-05 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 3,000 8,107E-08 3,251E-05 ! apoptotic mitochondrial changes GO:0008637 41 20 4,000 9,835E-08 3,38E-05 ! cell structure disassembly during apoptosis GO:0006921 30 21 4,000 1,285E-07 3,864E-05 ! motor axon guidance GO:0008045 16 9 3,000 1,452E-07 3,883E-05 ! apoptotic nuclear changes GO:0030262 32 22 4,000 1,655E-07 3,981E-05 ! regulation of cell-matrix adhesion GO:0001952 78 23 4,000 2,104E-07 4,602E-05 GO:0010810|regulation of cell-substrate adhesion, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 3,000 2,41E-07 4,831E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 3,000 2,41E-07 4,46E-05 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 4,000 2,645E-07 4,546E-05 ! regulation of mast cell proliferation GO:0070666 81 48 5,000 3,912E-07 6,275E-05 ! regulation of B cell proliferation GO:0030888 20 12 3,000 5,627E-07 8,462E-05 ! T cell homeostasis GO:0043029 25 12 3,000 5,627E-07 7,964E-05 ! negative regulation of mast cell proliferation GO:0070667 23 12 3,000 5,627E-07 7,522E-05 GO:0042130|negative regulation of T cell proliferation, ! regulation of leukocyte proliferation GO:0070663 88 51 5,000 5,657E-07 7,164E-05 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of B cell activation GO:0050864 50 30 4,000 8,617E-07 1,037E-04 ! regulation of cell adhesion GO:0030155 212 89 6,000 1,025E-06 1,175E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 5,000 1,107E-06 1,211E-04 ! release of cytochrome c from mitochondria GO:0001836 30 14 3,000 1,127E-06 1,179E-04 ! lymphocyte homeostasis GO:0002260 30 15 3,000 1,53E-06 1,534E-04 ! regulation of homeostatic process GO:0032844 134 62 5,000 1,83E-06 1,761E-04 ! 2-oxoglutarate metabolic process GO:0006103 7 5 2,000 2,012E-06 1,862E-04 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 2,000 2,012E-06 1,793E-04 ! negative regulation of survival gene product expression GO:0008634 8 5 2,000 2,012E-06 1,729E-04 ! valine metabolic process GO:0006573 10 5 2,000 2,012E-06 1,67E-04 ! B cell homeostasis GO:0001782 13 5 2,000 2,012E-06 1,614E-04 ! negative regulation of leukocyte proliferation GO:0070664 31 16 3,000 2,031E-06 1,576E-04 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of survival gene product expression GO:0045884 33 17 3,000 2,644E-06 1,988E-04 ! nucleus organization GO:0006997 67 38 4,000 2,921E-06 2,13E-04 ! neuron apoptosis GO:0051402 9 6 2,000 4,007E-06 2,836E-04 ! establishment of spindle localization GO:0051293 12 6 2,000 4,007E-06 2,755E-04 GO:0051653|spindle localization, ! negative regulation of B cell activation GO:0050869 13 6 2,000 4,007E-06 2,678E-04 ! regulation of T cell proliferation GO:0042129 71 41 4,000 4,299E-06 2,796E-04 ! negative regulation of T cell activation GO:0050868 40 20 3,000 5,308E-06 3,361E-04 ! induction of apoptosis by intracellular signals GO:0008629 93 45 4,000 6,877E-06 4,242E-04 ! oxaloacetate metabolic process GO:0006107 10 7 2,000 6,982E-06 4,2E-04 ! response to hypoxia GO:0001666 171 81 5,000 8,805E-06 5,167E-04 ! positive regulation of cell cycle GO:0045787 89 48 4,000 9,5E-06 5,442E-04 ! cellular component disassembly GO:0022411 86 48 4,000 9,5E-06 5,316E-04 ! activation of pro-apoptotic gene products GO:0008633 47 23 3,000 9,567E-06 5,232E-04 ! response to oxygen levels GO:0070482 176 83 5,000 1,014E-05 5,422E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 2,000 1,112E-05 5,818E-04 ! succinate metabolic process GO:0006105 14 8 2,000 1,112E-05 5,694E-04 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 1,112E-05 5,575E-04 ! leukocyte homeostasis GO:0001776 44 24 3,000 1,143E-05 5,611E-04 ! mitochondrion organization GO:0007005 148 86 5,000 1,245E-05 5,99E-04 ! regulation of activated T cell proliferation GO:0046006 16 9 2,000 1,661E-05 7,837E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 2,000 1,661E-05 7,686E-04 ! phosphagen metabolic process GO:0006599 12 9 2,000 1,661E-05 7,541E-04 GO:0006600|creatine metabolic process, ! negative regulation of lymphocyte activation GO:0051250 53 27 3,000 1,862E-05 8,294E-04 ! DNA catabolic process GO:0006308 86 59 4,000 2,636E-05 1,153E-03 ! positive regulation of multicellular organism growth GO:0040018 51 30 3,000 2,867E-05 1,232E-03 ! negative regulation of leukocyte activation GO:0002695 56 30 3,000 2,867E-05 1,21E-03 ! response to peptide hormone stimulus GO:0043434 122 61 4,000 3,102E-05 1,287E-03 ! focal adhesion formation GO:0048041 35 12 2,000 4,294E-05 1,751E-03 ! negative regulation of protein kinase activity GO:0006469 130 67 4,000 4,894E-05 1,963E-03 ! negative regulation of kinase activity GO:0033673 131 68 4,000 5,257E-05 2,074E-03 ! androgen receptor signaling pathway GO:0030521 74 36 3,000 5,994E-05 2,326E-03 ! negative regulation of cell activation GO:0050866 65 36 3,000 5,994E-05 2,289E-03 ! negative regulation of transferase activity GO:0051348 140 72 4,000 6,923E-05 2,603E-03 ! tRNA modification GO:0006400 20 14 2,000 7,043E-05 2,607E-03 ! regulation of erythrocyte differentiation GO:0045646 44 14 2,000 7,043E-05 2,568E-03 ! epithelial to mesenchymal transition GO:0001837 28 15 2,000 8,766E-05 3,148E-03 ! mesenchymal cell development GO:0014031 87 40 3,000 9,13E-05 3,23E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! G1 phase of mitotic cell cycle GO:0000080 35 16 2,000 1,074E-04 3,746E-03 ! defense response to virus GO:0051607 37 16 2,000 1,074E-04 3,692E-03 ! regulation of intracellular protein transport GO:0033157 80 42 3,000 1,108E-04 3,754E-03 ! neuron migration GO:0001764 79 42 3,000 1,108E-04 3,702E-03 ! T cell activation GO:0042110 168 81 4,000 1,215E-04 4,003E-03 ! regulation of epithelial cell proliferation GO:0050678 111 43 3,000 1,216E-04 3,953E-03 ! branched chain family amino acid metabolic process GO:0009081 33 17 2,000 1,299E-04 4,166E-03 ! JAK-STAT cascade GO:0007259 71 44 3,000 1,331E-04 4,215E-03 ! cell-substrate junction assembly GO:0007044 54 18 2,000 1,552E-04 4,849E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 1,552E-04 4,786E-03 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 3,000 1,586E-04 4,83E-03 ! pigmentation GO:0043473 100 46 3,000 1,586E-04 4,769E-03 ! gland development GO:0048732 206 88 4,000 1,796E-04 5,336E-03 ! visual learning GO:0008542 36 19 2,000 1,835E-04 5,383E-03 ! G1 phase GO:0051318 40 19 2,000 1,835E-04 5,318E-03 ! regulation of lymphocyte differentiation GO:0045619 81 48 3,000 1,874E-04 5,366E-03 ! response to protein stimulus GO:0051789 149 91 4,000 2,102E-04 5,951E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 2,000 2,149E-04 6,012E-03 ! response to alkaloid GO:0043279 38 20 2,000 2,149E-04 5,943E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 2,149E-04 5,876E-03 ! negative regulation of immune system process GO:0002683 95 50 3,000 2,197E-04 5,94E-03 ! positive regulation of MAP kinase activity GO:0043406 160 93 4,000 2,327E-04 6,221E-03 ! regulation of membrane potential GO:0042391 164 93 4,000 2,327E-04 6,153E-03 ! regulation of T cell activation GO:0050863 158 94 4,000 2,446E-04 6,398E-03 ! cell aging GO:0007569 44 21 2,000 2,496E-04 6,458E-03 ! positive regulation of growth GO:0045927 90 52 3,000 2,559E-04 6,551E-03 ! leukocyte differentiation GO:0002521 202 96 4,000 2,698E-04 6,834E-03 ! regulation of neuron apoptosis GO:0043523 100 53 3,000 2,755E-04 6,906E-03 ! regulation of DNA metabolic process GO:0051052 178 97 4,000 2,832E-04 7,023E-03 ! regulation of protein localization GO:0032880 176 97 4,000 2,832E-04 6,952E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 2,878E-04 6,994E-03 ! positive regulation of intracellular transport GO:0032388 37 22 2,000 2,878E-04 6,924E-03 ! positive regulation of B cell activation GO:0050871 38 22 2,000 2,878E-04 6,856E-03 ! response to virus GO:0009615 160 98 4,000 2,97E-04 7,005E-03 ! aging GO:0007568 103 55 3,000 3,18E-04 7,428E-03 ! regulation of multicellular organism growth GO:0040014 85 55 3,000 3,18E-04 7,357E-03 ! cell cycle arrest GO:0007050 213 100 4,000 3,261E-04 7,472E-03 ! positive regulation of cell adhesion GO:0045785 56 23 2,000 3,295E-04 7,48E-03 ! visual behavior GO:0007632 42 23 2,000 3,295E-04 7,41E-03 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 1,000 3,433E-04 7,648E-03 ! skeletal myofibril assembly GO:0014866 10 5 1,000 3,433E-04 7,578E-03 ! smooth muscle tissue development GO:0048745 28 5 1,000 3,433E-04 7,509E-03 ! cardiac muscle fiber development GO:0048739 10 5 1,000 3,433E-04 7,442E-03 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 1,000 3,433E-04 7,375E-03 ! microvillus organization GO:0032528 7 5 1,000 3,433E-04 7,31E-03 GO:0030033|microvillus assembly, ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 3,433E-04 7,246E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 3,433E-04 7,183E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 3,433E-04 7,121E-03 ! meiotic chromosome segregation GO:0045132 7 5 1,000 3,433E-04 7,06E-03 ! forebrain morphogenesis GO:0048853 13 5 1,000 3,433E-04 7E-03 ! base-excision repair, DNA ligation GO:0006288 7 5 1,000 3,433E-04 6,941E-03 ! metaphase GO:0051323 8 5 1,000 3,433E-04 6,884E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 3,433E-04 6,827E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 3,433E-04 6,771E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 1,000 3,433E-04 6,716E-03 GO:0022011|myelination in the peripheral nervous system, ! stem cell division GO:0017145 11 5 1,000 3,433E-04 6,662E-03 GO:0048103|somatic stem cell division, ! regulation of bone remodeling GO:0046850 137 57 3,000 3,649E-04 7,024E-03 ! positive regulation of cell migration GO:0030335 126 57 3,000 3,649E-04 6,969E-03 ! regulation of intracellular transport GO:0032386 101 57 3,000 3,649E-04 6,914E-03 ! positive regulation of fibroblast proliferation GO:0048146 43 24 2,000 3,75E-04 7,048E-03 ! lymphocyte proliferation GO:0046651 48 24 2,000 3,75E-04 6,994E-03 ! negative regulation of phosphorylation GO:0042326 47 24 2,000 3,75E-04 6,94E-03 ! regulation of tissue remodeling GO:0034103 140 58 3,000 3,902E-04 7,166E-03 ! establishment of organelle localization GO:0051656 109 59 3,000 4,166E-04 7,594E-03 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 2,000 4,243E-04 7,675E-03 ! myelination GO:0042552 45 25 2,000 4,243E-04 7,618E-03 ! dicarboxylic acid metabolic process GO:0043648 42 25 2,000 4,243E-04 7,561E-03 ! response to endoplasmic reticulum stress GO:0034976 43 25 2,000 4,243E-04 7,506E-03 ! regulation of transcription factor import into nucleus GO:0042990 54 26 2,000 4,775E-04 8,386E-03 ! insulin receptor signaling pathway GO:0008286 64 26 2,000 4,775E-04 8,325E-03 ! leukocyte proliferation GO:0070661 52 26 2,000 4,775E-04 8,265E-03 GO:0032943|mononuclear cell proliferation, ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 2,000 4,775E-04 8,206E-03 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 2,000 4,775E-04 8,148E-03 GO:0045936|negative regulation of phosphate metabolic process, ! neuron remodeling GO:0016322 15 6 1,000 5,13E-04 8,692E-03 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 1,000 5,13E-04 8,631E-03 ! negative regulation of gliogenesis GO:0014014 18 6 1,000 5,13E-04 8,571E-03 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 12 6 1,000 5,13E-04 8,512E-03 ! neural nucleus development GO:0048857 14 6 1,000 5,13E-04 8,454E-03 ! response to UV-C GO:0010225 11 6 1,000 5,13E-04 8,396E-03 ! astrocyte development GO:0014002 15 6 1,000 5,13E-04 8,339E-03 ! positive regulation of B cell differentiation GO:0045579 11 6 1,000 5,13E-04 8,283E-03 ! Schwann cell development GO:0014044 15 6 1,000 5,13E-04 8,228E-03 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 5,13E-04 8,174E-03 ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 5,13E-04 8,12E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 5,13E-04 8,067E-03 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 5,349E-04 8,357E-03 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 2,000 5,349E-04 8,303E-03 ! mitochondrial membrane organization GO:0007006 57 27 2,000 5,349E-04 8,249E-03 ! regulation of chromosome organization GO:0033044 42 27 2,000 5,349E-04 8,197E-03 ! steroid hormone receptor signaling pathway GO:0030518 129 63 3,000 5,354E-04 8,152E-03 ! positive regulation of cell motion GO:0051272 146 64 3,000 5,684E-04 8,602E-03 ! ER-nuclear signaling pathway GO:0006984 48 28 2,000 5,965E-04 8,969E-03 ! peptidyl-tyrosine modification GO:0018212 50 28 2,000 5,965E-04 8,914E-03 ! negative regulation of neuron apoptosis GO:0043524 56 29 2,000 6,624E-04 9,838E-03 ! negative regulation of cell growth GO:0030308 132 67 3,000 6,764E-04 9,984E-03 ! homeostasis of number of cells GO:0048872 114 67 3,000 6,764E-04 9,923E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 3,000 7,154E-04 0,01043124 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 1,000 7,154E-04 0,01036865 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 7,154E-04 0,01030656 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 7,154E-04 0,01024521 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 7,154E-04 0,01018459 ! DNA ligation during DNA repair GO:0051103 13 7 1,000 7,154E-04 0,01012468 ! adrenal gland development GO:0030325 17 7 1,000 7,154E-04 0,01006547 ! induction of apoptosis by oxidative stress GO:0008631 8 7 1,000 7,154E-04 0,01000695 ! positive regulation of activated T cell proliferation GO:0042104 12 7 1,000 7,154E-04 9,949E-03 ! organ growth GO:0035265 15 7 1,000 7,154E-04 9,892E-03 ! positive regulation of mitotic cell cycle GO:0045931 12 7 1,000 7,154E-04 9,835E-03 ! centrosome duplication GO:0051298 13 7 1,000 7,154E-04 9,78E-03 ! B cell lineage commitment GO:0002326 21 7 1,000 7,154E-04 9,724E-03 ! T cell lineage commitment GO:0002360 16 7 1,000 7,154E-04 9,67E-03 ! peptidyl-threonine modification GO:0018210 25 7 1,000 7,154E-04 9,616E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 7,154E-04 9,562E-03 ! cell junction assembly GO:0034329 78 30 2,000 7,328E-04 9,741E-03 ! ensheathment of neurons GO:0007272 57 30 2,000 7,328E-04 9,688E-03 GO:0008366|axon ensheathment, ! negative regulation of cell size GO:0045792 134 69 3,000 7,559E-04 9,938E-03 ! ovulation cycle process GO:0022602 49 31 2,000 8,078E-04 0,01056328 ! regulation of caspase activity GO:0043281 122 72 3,000 8,873E-04 0,01153952 ! spindle organization GO:0007051 46 32 2,000 8,875E-04 0,01148082 ! metanephros development GO:0001656 74 32 2,000 8,875E-04 0,01141943 ! regulation of protein import into nucleus GO:0042306 63 32 2,000 8,875E-04 0,01135868 ! ovulation cycle GO:0042698 51 32 2,000 8,875E-04 0,01129859 ! peripheral nervous system development GO:0007422 64 32 2,000 8,875E-04 0,01123912 ! learning or memory GO:0007611 147 73 3,000 9,344E-04 0,01177095 ! axon guidance GO:0007411 139 73 3,000 9,344E-04 0,01170964 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 9,501E-04 0,01184459 ! pigment granule organization GO:0048753 16 8 1,000 9,501E-04 0,01178354 ! astrocyte differentiation GO:0048708 18 8 1,000 9,501E-04 0,01172311 ! ER overload response GO:0006983 12 8 1,000 9,501E-04 0,0116633 ! regulation of pigmentation during development GO:0048070 24 8 1,000 9,501E-04 0,01160409 ! melanin metabolic process GO:0006582 15 8 1,000 9,501E-04 0,01154549 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 9,501E-04 0,01148747 ! Schwann cell differentiation GO:0014037 19 8 1,000 9,501E-04 0,01143003 ! response to UV-B GO:0010224 16 8 1,000 9,501E-04 0,01137317 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 1,000 9,501E-04 0,01131686 ! regulation of Rac protein signal transduction GO:0035020 11 8 1,000 9,501E-04 0,01126111 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 1,000 9,501E-04 0,01120591 ! regulation of endopeptidase activity GO:0052548 125 74 3,000 9,833E-04 0,01154082 ! organelle localization GO:0051640 136 74 3,000 9,833E-04 0,01148479 ! lymphocyte differentiation GO:0030098 167 75 3,000 1,034E-03 0,01201808 ! regulation of striated muscle tissue development GO:0016202 69 34 2,000 1,062E-03 0,01227916 ! regulation of muscle development GO:0048634 70 35 2,000 1,156E-03 0,01330831 ! female gonad development GO:0008585 58 35 2,000 1,156E-03 0,01324493 ! 'de novo' posttranslational protein folding GO:0051084 14 9 1,000 1,217E-03 0,0138755 ! regulation of epithelial cell differentiation GO:0030856 14 9 1,000 1,217E-03 0,01381005 ! DNA synthesis during DNA repair GO:0000731 14 9 1,000 1,217E-03 0,01374522 ! elastic fiber assembly GO:0048251 15 9 1,000 1,217E-03 0,01368099 ! artery development GO:0060840 24 9 1,000 1,217E-03 0,01361736 GO:0048844|artery morphogenesis, ! microtubule bundle formation GO:0001578 21 9 1,000 1,217E-03 0,01355431 ! middle ear morphogenesis GO:0042474 14 9 1,000 1,217E-03 0,01349185 ! T cell selection GO:0045058 23 9 1,000 1,217E-03 0,01342996 ! Rac protein signal transduction GO:0016601 17 9 1,000 1,217E-03 0,01336864 ! behavioral fear response GO:0001662 22 9 1,000 1,217E-03 0,01330787 GO:0002209|behavioral defense response, ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 1,217E-03 0,01324765 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 1,217E-03 0,01318798 ! postreplication repair GO:0006301 22 9 1,000 1,217E-03 0,01312884 ! regulation of telomere maintenance GO:0032204 14 9 1,000 1,217E-03 0,01307023 ! regulation of peptidase activity GO:0052547 134 79 3,000 1,255E-03 0,01342003 ! positive regulation of phosphorylation GO:0042327 129 79 3,000 1,255E-03 0,01336065 ! cell junction organization GO:0034330 86 36 2,000 1,256E-03 0,01330918 ! muscle cell differentiation GO:0042692 159 80 3,000 1,315E-03 0,01387688 ! meiosis I GO:0007127 65 37 2,000 1,361E-03 0,01429501 ! establishment or maintenance of cell polarity GO:0007163 83 37 2,000 1,361E-03 0,01423286 ! regulation of protein stability GO:0031647 73 37 2,000 1,361E-03 0,01417124 ! cellular response to insulin stimulus GO:0032869 82 37 2,000 1,361E-03 0,01411016 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 3,000 1,377E-03 0,01421934 GO:0045937|positive regulation of phosphate metabolic process, ! cellular response to hormone stimulus GO:0032870 167 82 3,000 1,441E-03 0,01481677 ! development of primary female sexual characteristics GO:0046545 67 38 2,000 1,471E-03 0,01505872 GO:0046660|female sex differentiation, ! positive regulation of leukocyte proliferation GO:0070665 62 38 2,000 1,471E-03 0,01499491 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 1,515E-03 0,01538165 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 1,000 1,515E-03 0,01531703 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 1,515E-03 0,01525294 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 1,000 1,515E-03 0,01518938 GO:0007520|myoblast fusion, ! COPI coating of Golgi vesicle GO:0048205 19 10 1,000 1,515E-03 0,01512636 GO:0048200|Golgi transport vesicle coating, ! negative regulation of striated muscle development GO:0045843 19 10 1,000 1,515E-03 0,01506385 ! positive regulation of survival gene product expression GO:0045885 23 10 1,000 1,515E-03 0,01500186 ! B cell proliferation GO:0042100 18 10 1,000 1,515E-03 0,01494038 ! regulation of bone resorption GO:0045124 25 10 1,000 1,515E-03 0,0148794 ! regulation of gliogenesis GO:0014013 23 10 1,000 1,515E-03 0,01481891 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 1,000 1,515E-03 0,01475891 ! alpha-beta T cell activation GO:0046631 23 10 1,000 1,515E-03 0,0146994 ! DNA ligation GO:0006266 19 10 1,000 1,515E-03 0,01464037 ! regulation of B cell differentiation GO:0045577 19 10 1,000 1,515E-03 0,01458181 ! negative regulation of MAPKKK cascade GO:0043409 20 10 1,000 1,515E-03 0,01452371 ! oocyte development GO:0048599 17 10 1,000 1,515E-03 0,01446608 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 1,000 1,515E-03 0,0144089 ! response to nicotine GO:0035094 20 10 1,000 1,515E-03 0,01435217 ! establishment of cell polarity GO:0030010 16 10 1,000 1,515E-03 0,01429589 ! localization within membrane GO:0051668 20 10 1,000 1,515E-03 0,01424005 ! negative regulation of growth GO:0045926 155 84 3,000 1,575E-03 0,01474713 ! mammary gland development GO:0030879 86 39 2,000 1,587E-03 0,01479515 ! learning GO:0007612 77 39 2,000 1,587E-03 0,01473803 ! regulation of action potential in neuron GO:0019228 73 39 2,000 1,587E-03 0,01468134 ! RNA modification GO:0009451 57 39 2,000 1,587E-03 0,01462509 ! response to unfolded protein GO:0006986 131 85 3,000 1,645E-03 0,01511086 ! cytokinesis GO:0000910 72 40 2,000 1,708E-03 0,01562296 ! tube morphogenesis GO:0035239 176 86 3,000 1,718E-03 0,01565624 ! regulation of protein transport GO:0051223 154 87 3,000 1,792E-03 0,01627434 GO:0070201|regulation of establishment of protein localization, ! cellular amide metabolic process GO:0043603 67 41 2,000 1,835E-03 0,01659433 ! gliogenesis GO:0042063 88 41 2,000 1,835E-03 0,01653218 ! T cell differentiation GO:0030217 81 41 2,000 1,835E-03 0,01647049 ! regulation of T cell differentiation GO:0045580 70 41 2,000 1,835E-03 0,01640926 ! negative regulation of muscle development GO:0048635 20 11 1,000 1,845E-03 0,01643799 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 1,000 1,845E-03 0,01637733 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 1,845E-03 0,01631712 ! Golgi vesicle budding GO:0048194 22 11 1,000 1,845E-03 0,01625735 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,845E-03 0,01619802 ! T cell proliferation GO:0042098 26 11 1,000 1,845E-03 0,01613912 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 1,000 1,845E-03 0,01608064 GO:0010812|negative regulation of cell-substrate adhesion, ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 1,845E-03 0,01602259 ! syncytium formation GO:0006949 18 11 1,000 1,845E-03 0,01596495 ! negative regulation of ossification GO:0030279 26 11 1,000 1,845E-03 0,01590773 ! DNA methylation GO:0006306 19 11 1,000 1,845E-03 0,01585092 GO:0006305|DNA alkylation, ! oocyte differentiation GO:0009994 18 11 1,000 1,845E-03 0,01579451 ! thymus development GO:0048538 27 11 1,000 1,845E-03 0,0157385 ! germ cell migration GO:0008354 25 11 1,000 1,845E-03 0,01568289 ! response to reactive oxygen species GO:0000302 67 42 2,000 1,967E-03 0,01666596 ! regulation of myeloid cell differentiation GO:0045637 98 42 2,000 1,967E-03 0,01660748 ! striated muscle cell differentiation GO:0051146 82 43 2,000 2,106E-03 0,0177139 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 1,000 2,205E-03 0,01848518 ! asymmetric protein localization GO:0008105 20 12 1,000 2,205E-03 0,01842099 ! membrane protein proteolysis GO:0033619 25 12 1,000 2,205E-03 0,01835725 GO:0006509|membrane protein ectodomain proteolysis, ! fear response GO:0042596 26 12 1,000 2,205E-03 0,01829395 ! histone acetylation GO:0016573 26 12 1,000 2,205E-03 0,01823108 ! autonomic nervous system development GO:0048483 24 12 1,000 2,205E-03 0,01816865 ! gland morphogenesis GO:0022612 29 12 1,000 2,205E-03 0,01810664 ! peptidyl-lysine modification GO:0018205 21 12 1,000 2,205E-03 0,01804505 ! spleen development GO:0048536 22 12 1,000 2,205E-03 0,01798388 ! digestive tract morphogenesis GO:0048546 26 12 1,000 2,205E-03 0,01792313 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 1,000 2,205E-03 0,01786278 ! male sex differentiation GO:0046661 76 44 2,000 2,25E-03 0,01816588 ! glycolysis GO:0006096 65 45 2,000 2,4E-03 0,01931474 ! branching morphogenesis of a tube GO:0048754 97 45 2,000 2,4E-03 0,01925036 ! negative regulation of cell migration GO:0030336 115 46 2,000 2,557E-03 0,02043656 ! response to insulin stimulus GO:0032868 95 46 2,000 2,557E-03 0,02036889 ! positive regulation of protein transport GO:0051222 72 46 2,000 2,557E-03 0,02030166 ! 'de novo' protein folding GO:0006458 25 13 1,000 2,596E-03 0,02054448 ! lipid localization GO:0010876 28 13 1,000 2,596E-03 0,02047712 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 1,000 2,596E-03 0,0204102 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 1,000 2,596E-03 0,02034372 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 2,596E-03 0,02027766 ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 2,596E-03 0,02021204 ! regulation of DNA repair GO:0006282 21 13 1,000 2,596E-03 0,02014684 ! regulation of monooxygenase activity GO:0032768 33 13 1,000 2,596E-03 0,02008206 ! positive regulation of Ras GTPase activity GO:0032320 35 13 1,000 2,596E-03 0,02001769 ! skeletal muscle tissue development GO:0007519 186 99 3,000 2,87E-03 0,02206087 GO:0060538|skeletal muscle organ development, ! mitochondrial transport GO:0006839 82 48 2,000 2,888E-03 0,02212939 ! activation of caspase activity GO:0006919 84 48 2,000 2,888E-03 0,02205914 ! lactation GO:0007595 26 14 1,000 3,017E-03 0,02296898 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 3,017E-03 0,02289652 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 1,000 3,017E-03 0,02282452 ! actin cytoskeleton reorganization GO:0031532 33 14 1,000 3,017E-03 0,02275297 ! negative regulation of protein import into nucleus GO:0042308 30 14 1,000 3,017E-03 0,02268187 ! T cell differentiation in the thymus GO:0033077 31 14 1,000 3,017E-03 0,02261121 ! response to gamma radiation GO:0010332 28 14 1,000 3,017E-03 0,02254099 ! myotube differentiation GO:0014902 25 14 1,000 3,017E-03 0,0224712 ! positive regulation of GTPase activity GO:0043547 36 14 1,000 3,017E-03 0,02240184 ! hair follicle morphogenesis GO:0031069 26 14 1,000 3,017E-03 0,02233291 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 3,017E-03 0,02226441 GO:0060675|ureteric bud morphogenesis, ! regulation of action potential GO:0001508 95 49 2,000 3,063E-03 0,02253803 ! regulation of ossification GO:0030278 117 50 2,000 3,245E-03 0,02380065 ! vesicle organization GO:0016050 107 51 2,000 3,433E-03 0,02510286 ! epithelial tube morphogenesis GO:0060562 98 51 2,000 3,433E-03 0,02502679 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 3,467E-03 0,02520361 ! vesicle coating GO:0006901 33 15 1,000 3,467E-03 0,0251277 ! intermediate filament cytoskeleton organization GO:0045104 31 15 1,000 3,467E-03 0,02505224 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 3,467E-03 0,02497723 ! regulation of angiogenesis GO:0045765 114 52 2,000 3,627E-03 0,0260501 ! morphogenesis of a branching structure GO:0001763 111 52 2,000 3,627E-03 0,02597257 ! embryonic forelimb morphogenesis GO:0035115 28 16 1,000 3,947E-03 0,02818174 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 1,000 3,947E-03 0,02809836 ! fructose metabolic process GO:0006000 25 16 1,000 3,947E-03 0,02801547 ! intermediate filament-based process GO:0045103 32 16 1,000 3,947E-03 0,02793307 ! positive regulation of protein import into nucleus GO:0042307 30 16 1,000 3,947E-03 0,02785116 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 3,947E-03 0,02776972 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 3,947E-03 0,02768876 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 1,000 3,947E-03 0,02760827 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 1,000 3,947E-03 0,02752825 ! induction of apoptosis via death domain receptors GO:0008625 20 16 1,000 3,947E-03 0,02744869 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 3,947E-03 0,02736958 GO:0031114|regulation of microtubule depolymerization, ! NLS-bearing substrate import into nucleus GO:0006607 46 16 1,000 3,947E-03 0,02729093 ! positive regulation of caspase activity GO:0043280 95 55 2,000 4,25E-03 0,02930249 GO:0010952|positive regulation of peptidase activity, ! glucose catabolic process GO:0006007 82 55 2,000 4,25E-03 0,02921877 ! negative regulation of cell motion GO:0051271 134 55 2,000 4,25E-03 0,02913553 ! metencephalon development GO:0022037 30 17 1,000 4,456E-03 0,03045989 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 4,456E-03 0,0303736 ! endothelial cell migration GO:0043542 28 17 1,000 4,456E-03 0,0302878 ! glial cell development GO:0021782 27 17 1,000 4,456E-03 0,03020248 ! regulation of viral genome replication GO:0045069 28 17 1,000 4,456E-03 0,03011765 ! cardiac muscle tissue development GO:0048738 31 17 1,000 4,456E-03 0,03003328 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 4,456E-03 0,02994939 ! membrane budding GO:0006900 37 17 1,000 4,456E-03 0,02986597 ! regulation of protein binding GO:0043393 33 17 1,000 4,456E-03 0,02978301 ! DNA unwinding during replication GO:0006268 27 17 1,000 4,456E-03 0,0297005 ! negative regulation of homeostatic process GO:0032845 33 17 1,000 4,456E-03 0,02961846 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 4,456E-03 0,02953687 ! skeletal muscle fiber development GO:0048741 111 56 2,000 4,472E-03 0,02955771 ! muscle fiber development GO:0048747 112 57 2,000 4,7E-03 0,03098069 ! neuron maturation GO:0042551 42 18 1,000 4,994E-03 0,0328291 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 4,994E-03 0,03273965 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 1,000 4,994E-03 0,03265068 ! patterning of blood vessels GO:0001569 39 18 1,000 4,994E-03 0,0325622 ! centrosome cycle GO:0007098 25 18 1,000 4,994E-03 0,03247419 ! epidermis morphogenesis GO:0048730 40 18 1,000 4,994E-03 0,03238666 ! regulation of steroid metabolic process GO:0019218 30 18 1,000 4,994E-03 0,0322996 ! integrin-mediated signaling pathway GO:0007229 135 59 2,000 5,177E-03 0,0333939 ! protein amino acid autophosphorylation GO:0046777 141 60 2,000 5,426E-03 0,03490704 ! kidney development GO:0001822 122 60 2,000 5,426E-03 0,03481395 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 1,000 5,56E-03 0,0355774 ! lipid phosphorylation GO:0046834 35 19 1,000 5,56E-03 0,03548303 ! forelimb morphogenesis GO:0035136 32 19 1,000 5,56E-03 0,03538916 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 1,000 5,56E-03 0,03529578 ! cerebral cortex development GO:0021987 36 19 1,000 5,56E-03 0,0352029 ! cellular response to unfolded protein GO:0034620 33 19 1,000 5,56E-03 0,0351105 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 42 19 1,000 5,56E-03 0,03501859 ! neuromuscular junction development GO:0007528 34 19 1,000 5,56E-03 0,03492716 ! plasma membrane fusion GO:0045026 28 19 1,000 5,56E-03 0,0348362 ! regulation of endothelial cell migration GO:0010594 44 19 1,000 5,56E-03 0,03474572 ! cellular pigmentation GO:0033059 36 19 1,000 5,56E-03 0,03465571 ! tRNA processing GO:0008033 89 61 2,000 5,682E-03 0,03532712 ! ear development GO:0043583 103 62 2,000 5,946E-03 0,03686892 ! gonad development GO:0008406 98 62 2,000 5,946E-03 0,03677414 ! protein amino acid acetylation GO:0006473 39 20 1,000 6,154E-03 0,03796409 ! DNA duplex unwinding GO:0032508 31 20 1,000 6,154E-03 0,037867 GO:0032392|DNA geometric change, ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 6,154E-03 0,0377704 ! regulation of interleukin-2 production GO:0032663 35 20 1,000 6,154E-03 0,03767429 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 1,000 6,154E-03 0,03757867 ! camera-type eye morphogenesis GO:0048593 42 20 1,000 6,154E-03 0,03748354 ! actin filament-based movement GO:0030048 43 20 1,000 6,154E-03 0,03738888 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 2,000 6,494E-03 0,03935584 ! multicellular organism reproduction GO:0032504 111 64 2,000 6,494E-03 0,03925696 GO:0048609|reproductive process in a multicellular organism, ! hindlimb morphogenesis GO:0035137 43 21 1,000 6,775E-03 0,04085539 ! ovarian follicle development GO:0001541 35 21 1,000 6,775E-03 0,04075325 ! smooth muscle contraction GO:0006939 46 21 1,000 6,775E-03 0,04065162 ! oogenesis GO:0048477 36 21 1,000 6,775E-03 0,0405505 ! DNA modification GO:0006304 34 21 1,000 6,775E-03 0,04044988 ! collagen fibril organization GO:0030199 59 21 1,000 6,775E-03 0,04034975 ! negative regulation of intracellular transport GO:0032387 41 21 1,000 6,775E-03 0,04025012 ! positive regulation of inflammatory response GO:0050729 35 21 1,000 6,775E-03 0,04015099 ! response to cytokine stimulus GO:0034097 63 21 1,000 6,775E-03 0,04005233 ! gut development GO:0048565 39 21 1,000 6,775E-03 0,03995417 ! germ cell development GO:0007281 118 65 2,000 6,779E-03 0,03987797 ! actin filament organization GO:0007015 148 66 2,000 7,071E-03 0,04149648 ! extracellular matrix organization GO:0030198 133 66 2,000 7,071E-03 0,04139552 ! activation of MAPK activity GO:0000187 115 67 2,000 7,371E-03 0,0430456 ! hexose catabolic process GO:0019320 104 67 2,000 7,371E-03 0,04294137 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 2,000 7,371E-03 0,04283765 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 1,000 7,424E-03 0,04304142 ! regeneration GO:0031099 41 22 1,000 7,424E-03 0,04293795 ! cellular response to reactive oxygen species GO:0034614 31 22 1,000 7,424E-03 0,04283498 ! ureteric bud development GO:0001657 43 22 1,000 7,424E-03 0,04273251 ! renal system process GO:0003014 41 22 1,000 7,424E-03 0,04263052 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 7,424E-03 0,04252902 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 1,000 7,424E-03 0,042428 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 1,000 7,424E-03 0,04232746 ! negative regulation of ligase activity GO:0051352 112 68 2,000 7,678E-03 0,04367347 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! cell cycle checkpoint GO:0000075 137 69 2,000 7,993E-03 0,04535597 ! urogenital system development GO:0001655 137 69 2,000 7,993E-03 0,04524925 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 1,000 8,1E-03 0,0457461 ! myeloid leukocyte differentiation GO:0002573 40 23 1,000 8,1E-03 0,04563897 ! regulation of DNA recombination GO:0000018 48 23 1,000 8,1E-03 0,04553234 ! response to ethanol GO:0045471 46 23 1,000 8,1E-03 0,0454262 ! vesicle targeting GO:0006903 43 23 1,000 8,1E-03 0,04532056 ! regulation of viral reproduction GO:0050792 38 23 1,000 8,1E-03 0,04521541 ! reproductive structure development GO:0048608 113 71 2,000 8,645E-03 0,04814653 ! spinal cord development GO:0021510 47 24 1,000 8,802E-03 0,04890865 ! multicellular organismal response to stress GO:0033555 49 24 1,000 8,802E-03 0,04879596 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 8,802E-03 0,04868378 ! pallium development GO:0021543 49 24 1,000 8,802E-03 0,04857212 ! regulation of oxidoreductase activity GO:0051341 46 24 1,000 8,802E-03 0,04846097 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 2,000 8,982E-03 0,04933973 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 1,000 9,53E-03 0,05223281 ! somitogenesis GO:0001756 43 25 1,000 9,53E-03 0,05211409 ! neural tube closure GO:0001843 49 25 1,000 9,53E-03 0,05199592 GO:0060606|tube closure, ! liver development GO:0001889 53 25 1,000 9,53E-03 0,05187828 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 1,000 9,53E-03 0,05176118 ! osteoblast differentiation GO:0001649 60 25 1,000 9,53E-03 0,0516446 ! negative regulation of cell development GO:0010721 73 25 1,000 9,53E-03 0,05152854 GO:0050768|negative regulation of neurogenesis, ! regulation of transcription factor activity GO:0051090 126 74 2,000 9,679E-03 0,05221716 GO:0090046|regulation of transcription regulator activity, ! meiosis GO:0007126 121 74 2,000 9,679E-03 0,05210034 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 163 75 2,000 0,01003972 0,05391867 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 0,01003972 0,05379859 ! meiotic cell cycle GO:0051321 122 75 2,000 0,01003972 0,05367903 ! rhythmic process GO:0048511 128 75 2,000 0,01003972 0,05356001 ! initiation of viral infection GO:0019059 57 26 1,000 0,01028483 0,05474626 ! molting cycle process GO:0022404 50 26 1,000 0,01028483 0,05462541 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! tube lumen formation GO:0035148 50 26 1,000 0,01028483 0,05450509 ! microtubule organizing center organization GO:0031023 39 26 1,000 0,01028483 0,0543853 GO:0051297|centrosome organization, ! regulation of endothelial cell proliferation GO:0001936 57 26 1,000 0,01028483 0,05426603 ! cellular response to oxidative stress GO:0034599 39 26 1,000 0,01028483 0,05414729 ! positive regulation of nuclear division GO:0051785 40 26 1,000 0,01028483 0,05402906 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 65 26 1,000 0,01028483 0,05391135 ! development of primary sexual characteristics GO:0045137 124 76 2,000 0,01040766 0,0544366 ! monosaccharide catabolic process GO:0046365 115 76 2,000 0,01040766 0,05431852 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 0,01078335 0,05615744 ! protein amino acid acylation GO:0043543 55 27 1,000 0,01106483 0,05749888 ! fat cell differentiation GO:0045444 50 27 1,000 0,01106483 0,05737496 ! male gonad development GO:0008584 44 27 1,000 0,01106483 0,05725157 ! response to toxin GO:0009636 47 27 1,000 0,01106483 0,05712872 ! primary neural tube formation GO:0014020 51 27 1,000 0,01106483 0,05700639 ! base-excision repair GO:0006284 41 27 1,000 0,01106483 0,05688458 ! negative regulation of organelle organization GO:0010639 161 78 2,000 0,01116681 0,05728643 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 2,000 0,01155806 0,05916744 ! dendrite development GO:0016358 59 28 1,000 0,01187009 0,06063574 ! response to metal ion GO:0010038 140 80 2,000 0,01195714 0,06095103 ! cell-substrate adhesion GO:0031589 171 81 2,000 0,01236407 0,06289208 ! cellular iron ion homeostasis GO:0006879 51 29 1,000 0,01270029 0,06446602 ! response to organic cyclic substance GO:0014070 55 29 1,000 0,01270029 0,0643303 ! cellular response to extracellular stimulus GO:0031668 48 29 1,000 0,01270029 0,06419515 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 1,000 0,01270029 0,06406057 ! tissue homeostasis GO:0001894 48 29 1,000 0,01270029 0,06392655 GO:0048871|multicellular organismal homeostasis, ! response to drug GO:0042493 143 82 2,000 0,01277887 0,06418781 ! myofibril assembly GO:0030239 47 30 1,000 0,01355511 0,06794497 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 68 30 1,000 0,01355511 0,06780371 ! eye morphogenesis GO:0048592 60 30 1,000 0,01355511 0,06766304 ! response to heat GO:0009408 50 30 1,000 0,01355511 0,06752295 ! regulation of ligase activity GO:0051340 142 84 2,000 0,01363217 0,06776651 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,0140707 0,06980229 GO:0002696|positive regulation of leukocyte activation, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 1,000 0,01443423 0,07145834 ! positive regulation of T cell proliferation GO:0042102 52 31 1,000 0,01443423 0,07131161 ! iron ion homeostasis GO:0055072 54 31 1,000 0,01443423 0,07116548 ! natural killer cell activation GO:0030101 45 31 1,000 0,01443423 0,07101995 ! negative regulation of transcription regulator activity GO:0090048 58 31 1,000 0,01443423 0,07087501 GO:0043433|negative regulation of transcription factor activity, ! response to inorganic substance GO:0010035 153 86 2,000 0,01451719 0,07113719 ! alcohol catabolic process GO:0046164 130 86 2,000 0,01451719 0,0709926 ! response to hydrogen peroxide GO:0042542 50 32 1,000 0,01533734 0,0748512 ! spliceosome assembly GO:0000245 67 32 1,000 0,01533734 0,07469968 ! response to ionizing radiation GO:0010212 65 32 1,000 0,01533734 0,07454877 ! response to mechanical stimulus GO:0009612 57 32 1,000 0,01533734 0,07439847 ! muscle cell development GO:0055001 49 32 1,000 0,01533734 0,07424878 ! negative regulation of MAP kinase activity GO:0043407 69 32 1,000 0,01533734 0,07409968 ! hindbrain development GO:0030902 61 32 1,000 0,01533734 0,07395119 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 1,000 0,01533734 0,07380329 ! positive regulation of protein modification process GO:0031401 136 88 2,000 0,01543408 0,07412055 ! regulation of DNA binding GO:0051101 155 88 2,000 0,01543408 0,0739729 ! DNA damage checkpoint GO:0000077 71 33 1,000 0,01626413 0,07779623 ! post-embryonic development GO:0009791 69 33 1,000 0,01626413 0,07764187 ! negative regulation of protein transport GO:0051224 69 33 1,000 0,01626413 0,07748812 ! establishment of vesicle localization GO:0051650 61 33 1,000 0,01626413 0,07733499 ! ossification GO:0001503 188 90 2,000 0,01638296 0,07774634 ! regulation of cell cycle process GO:0010564 149 90 2,000 0,01638296 0,07759329 ! sex differentiation GO:0007548 145 90 2,000 0,01638296 0,07744085 ! bone development GO:0060348 189 91 2,000 0,01686942 0,07958398 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 1,000 0,01721429 0,08105204 ! glial cell differentiation GO:0010001 63 34 1,000 0,01721429 0,08089374 ! regulation of synaptic plasticity GO:0048167 64 35 1,000 0,01818752 0,08530054 ! negative regulation of cell adhesion GO:0007162 81 35 1,000 0,01818752 0,08513459 ! telencephalon development GO:0021537 68 35 1,000 0,01818752 0,08496928 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,01818752 0,08480461 ! regulation of microtubule-based process GO:0032886 78 35 1,000 0,01818752 0,08464058 ! neural tube formation GO:0001841 67 35 1,000 0,01818752 0,08447718 ! vesicle localization GO:0051648 64 35 1,000 0,01818752 0,08431441 ! female pregnancy GO:0007565 164 94 2,000 0,01837705 0,0850292 ! forebrain development GO:0030900 188 95 2,000 0,0188957 0,08726115 ! mitotic sister chromatid segregation GO:0000070 57 36 1,000 0,01918351 0,08842056 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 1,000 0,01918351 0,08825149 ! positive regulation of cell development GO:0010720 80 36 1,000 0,01918351 0,08808307 ! DNA integrity checkpoint GO:0031570 75 36 1,000 0,01918351 0,0879153 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 1,000 0,02020197 0,09240671 ! sister chromatid segregation GO:0000819 58 37 1,000 0,02020197 0,09223136 ! actomyosin structure organization GO:0031032 62 37 1,000 0,02020197 0,09205668 ! negative regulation of DNA binding GO:0043392 68 37 1,000 0,02020197 0,09188266 ! glycogen metabolic process GO:0005977 61 37 1,000 0,02020197 0,0917093 ! pigment metabolic process GO:0042440 80 37 1,000 0,02020197 0,09153659 ! mitotic cell cycle checkpoint GO:0007093 76 38 1,000 0,02124258 0,09607079 ! embryonic epithelial tube formation GO:0001838 72 38 1,000 0,02124258 0,09589054 ! glucan metabolic process GO:0044042 62 38 1,000 0,02124258 0,09571097 GO:0006073|cellular glucan metabolic process, ! mRNA catabolic process GO:0006402 71 39 1,000 0,02230507 0,1003103 ! ear morphogenesis GO:0042471 60 39 1,000 0,02230507 0,10012315 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,02230507 0,0999367 ! segmentation GO:0035282 67 39 1,000 0,02230507 0,09975095 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 1,000 0,02338914 0,10440498 ! negative regulation of binding GO:0051100 72 40 1,000 0,02338914 0,10421163 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 0,02338914 0,10401901 ! keratinocyte differentiation GO:0030216 62 41 1,000 0,0244945 0,10873391 ! female gamete generation GO:0007292 61 41 1,000 0,0244945 0,10853366 ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,02562087 0,11331583 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of protein complex disassembly GO:0043242 101 42 1,000 0,02562087 0,11310791 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 1,000 0,02562087 0,11290075 ! energy reserve metabolic process GO:0006112 74 43 1,000 0,02676795 0,11773985 ! glucose transport GO:0015758 65 43 1,000 0,02676795 0,11752499 ! positive regulation of response to external stimulus GO:0032103 77 43 1,000 0,02676795 0,11731092 ! neural tube development GO:0021915 77 43 1,000 0,02676795 0,11709763 ! striated muscle contraction GO:0006941 77 43 1,000 0,02676795 0,11688511 ! hexose transport GO:0008645 67 44 1,000 0,02793548 0,12176224 GO:0015749|monosaccharide transport, ! biopolymer methylation GO:0043414 84 44 1,000 0,02793548 0,12154205 ! B cell differentiation GO:0030183 107 44 1,000 0,02793548 0,12132266 ! developmental growth GO:0048589 82 44 1,000 0,02793548 0,12110407 ! regulation of JAK-STAT cascade GO:0046425 70 45 1,000 0,02912316 0,12602576 ! leukocyte migration GO:0050900 68 45 1,000 0,02912316 0,1257995 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,02912316 0,12557405 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 1,000 0,02912316 0,12534941 ! cell growth GO:0016049 84 45 1,000 0,02912316 0,12512557 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,02920608 0,12525815 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,02920608 0,12503527 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02920608 0,12481318 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,02920608 0,12459188 ! neuron fate determination GO:0048664 7 5 0,000 0,02920608 0,12437136 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02920608 0,12415163 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,02920608 0,12393266 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,02920608 0,12371447 ! polyol transport GO:0015791 12 5 0,000 0,02920608 0,12349705 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,02920608 0,12328039 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02920608 0,12306448 ! response to superoxide GO:0000303 10 5 0,000 0,02920608 0,12284934 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02920608 0,12263494 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,02920608 0,12242129 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,02920608 0,12220838 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02920608 0,12199622 ! female meiosis GO:0007143 7 5 0,000 0,02920608 0,12178478 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02920608 0,12157408 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02920608 0,12136411 ! cobalt ion transport GO:0006824 11 5 0,000 0,02920608 0,12115486 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,02920608 0,12094634 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,02920608 0,12073852 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,02920608 0,12053142 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02920608 0,12032504 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02920608 0,12011935 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,02920608 0,11991437 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,02920608 0,11971009 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02920608 0,1195065 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,02920608 0,1193036 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,02920608 0,11910139 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02920608 0,11889987 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02920608 0,11869902 ! negative chemotaxis GO:0050919 14 5 0,000 0,02920608 0,11849885 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02920608 0,11829936 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02920608 0,11810054 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,02920608 0,11790238 ! behavioral response to pain GO:0048266 9 5 0,000 0,02920608 0,11770489 ! clathrin coat assembly GO:0048268 14 5 0,000 0,02920608 0,11750806 ! Notch receptor processing GO:0007220 8 5 0,000 0,02920608 0,11731189 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02920608 0,11711637 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02920608 0,1169215 ! micturition GO:0060073 9 5 0,000 0,02920608 0,11672728 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02920608 0,1165337 ! copulation GO:0007620 9 5 0,000 0,02920608 0,11634076 ! glial cell fate commitment GO:0021781 13 5 0,000 0,02920608 0,11614846 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,02920608 0,1159568 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02920608 0,11576577 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02920608 0,11557536 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02920608 0,11538558 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,02920608 0,11519643 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02920608 0,11500789 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02920608 0,11481997 ! grooming behavior GO:0007625 6 5 0,000 0,02920608 0,11463266 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02920608 0,11444596 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,02920608 0,11425987 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02920608 0,11407438 ! response to protozoan GO:0001562 10 5 0,000 0,02920608 0,1138895 ! positive regulation of glycolysis GO:0045821 14 5 0,000 0,02920608 0,11370521 ! lymph vessel development GO:0001945 10 5 0,000 0,02920608 0,11352152 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,02920608 0,11333842 ! endochondral ossification GO:0001958 16 5 0,000 0,02920608 0,11315591 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02920608 0,11297399 ! parathyroid gland development GO:0060017 13 5 0,000 0,02920608 0,11279265 ! anagen GO:0042640 6 5 0,000 0,02920608 0,11261189 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02920608 0,11243171 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02920608 0,11225211 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,02920608 0,11207308 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,02920608 0,11189462 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,02920608 0,11171673 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,02920608 0,1115394 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02920608 0,11136263 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02920608 0,11118643 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02920608 0,11101078 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,02920608 0,11083568 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02920608 0,11066113 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,02920608 0,11048714 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02920608 0,11031369 ! histidine catabolic process GO:0006548 6 5 0,000 0,02920608 0,11014078 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02920608 0,10996842 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,02920608 0,10979659 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02920608 0,10962531 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,02920608 0,10945455 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,02920608 0,10928432 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02920608 0,10911463 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,02920608 0,10894546 ! polyol catabolic process GO:0046174 7 5 0,000 0,02920608 0,10877681 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02920608 0,10860869 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02920608 0,10844108 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02920608 0,10827399 ! muscle cell migration GO:0014812 8 5 0,000 0,02920608 0,10810742 ! mitochondrial fission GO:0000266 8 5 0,000 0,02920608 0,10794135 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,02920608 0,1077758 ! mRNA transcription GO:0009299 9 5 0,000 0,02920608 0,10761075 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,02920608 0,10744621 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,02920608 0,10728217 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,02920608 0,10711863 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02920608 0,10695559 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02920608 0,10679304 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02920608 0,10663099 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02920608 0,10646943 ! response to food GO:0032094 6 5 0,000 0,02920608 0,10630835 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02920608 0,10614777 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02920608 0,10598766 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,02920608 0,10582804 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02920608 0,1056689 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,02920608 0,10551024 ! forebrain neuron development GO:0021884 13 5 0,000 0,02920608 0,10535206 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02920608 0,10519434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,02920608 0,1050371 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02920608 0,10488033 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02920608 0,10472402 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,02920608 0,10456819 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02920608 0,10441281 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,02920608 0,10425789 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,02920608 0,10410344 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02920608 0,10394944 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,02920608 0,10379589 ! basic amino acid transport GO:0015802 11 5 0,000 0,02920608 0,1036428 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,02920608 0,10349016 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,02920608 0,10333797 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02920608 0,10318623 ! depyrimidination GO:0045008 10 5 0,000 0,02920608 0,10303493 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02920608 0,10288407 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02920608 0,10273366 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,02920608 0,10258368 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,02920608 0,10243414 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02920608 0,10228504 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02920608 0,10213637 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,02920608 0,10198813 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,02920608 0,10184032 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02920608 0,10169294 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02920608 0,10154598 ! response to arsenic GO:0046685 10 5 0,000 0,02920608 0,10139945 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,02920608 0,10125334 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02920608 0,10110766 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,02920608 0,10096239 ! response to cadmium ion GO:0046686 7 5 0,000 0,02920608 0,10081753 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,02920608 0,1006731 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,02920608 0,10052907 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02920608 0,10038546 ! decidualization GO:0046697 11 5 0,000 0,02920608 0,10024225 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,02920608 0,10009946 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,02920608 0,09995707 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02920608 0,09981509 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02920608 0,0996735 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,02920608 0,09953232 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02920608 0,09939154 ! neural tube patterning GO:0021532 7 5 0,000 0,02920608 0,09925116 ! embryonic cleavage GO:0040016 6 5 0,000 0,02920608 0,09911117 ! peroxisome fission GO:0016559 5 5 0,000 0,02920608 0,09897158 ! histone demethylation GO:0016577 10 5 0,000 0,02920608 0,09883238 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,02920608 0,09869357 ! mitotic recombination GO:0006312 9 5 0,000 0,02920608 0,09855515 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02920608 0,09841712 ! metaphase plate congression GO:0051310 7 5 0,000 0,02920608 0,09827947 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02920608 0,09814221 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02920608 0,09800533 ! enteric nervous system development GO:0048484 8 5 0,000 0,02920608 0,09786883 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,02920608 0,09773271 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,02920608 0,09759697 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,02920608 0,09746161 ! muscle cell proliferation GO:0033002 11 5 0,000 0,02920608 0,09732662 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02920608 0,09719201 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,02920608 0,09705776 ! plasminogen activation GO:0031639 5 5 0,000 0,02920608 0,09692389 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,02920608 0,09679039 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02920608 0,09665725 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,02920608 0,09652448 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02920608 0,09639207 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02920608 0,09626003 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02920608 0,09612835 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02920608 0,09599702 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,02920608 0,09586606 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,02920608 0,09573545 ! response to redox state GO:0051775 5 5 0,000 0,02920608 0,0956052 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,02920608 0,0954753 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,02920608 0,09534575 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02920608 0,09521656 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,02920608 0,09508771 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02920608 0,09495922 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,02920608 0,09483107 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02920608 0,09470326 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,02920608 0,0945758 ! striatum development GO:0021756 9 5 0,000 0,02920608 0,09444868 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,02920608 0,09432191 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,02920608 0,09419547 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02920608 0,09406937 ! glial cell migration GO:0008347 11 5 0,000 0,02920608 0,09394361 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02920608 0,09381819 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02920608 0,09369309 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02920608 0,09356834 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02920608 0,09344391 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02920608 0,09331982 ! neuroprotection GO:0043526 6 5 0,000 0,02920608 0,09319605 ! neural plate development GO:0001840 8 5 0,000 0,02920608 0,09307261 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,02920608 0,0929495 ! regulation of sensory perception GO:0051931 7 5 0,000 0,02920608 0,09282671 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02920608 0,09270425 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,02920608 0,09258211 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,02920608 0,09246029 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02920608 0,09233879 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02920608 0,09221761 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02920608 0,09209675 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02920608 0,09197621 ! spindle assembly GO:0051225 6 5 0,000 0,02920608 0,09185597 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,02920608 0,09173606 GO:0016226|iron-sulfur cluster assembly, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02920608 0,09161645 ! drug metabolic process GO:0017144 6 5 0,000 0,02920608 0,09149716 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02920608 0,09137818 ! organ regeneration GO:0031100 7 5 0,000 0,02920608 0,09125951 ! carnitine metabolic process GO:0009437 7 5 0,000 0,02920608 0,09114114 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,02920608 0,09102308 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02920608 0,09090533 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 1,000 0,03033073 0,09428388 ! epidermal cell differentiation GO:0009913 68 46 1,000 0,03033073 0,09416223 ! positive regulation of defense response GO:0031349 76 47 1,000 0,0315579 0,09784577 ! response to calcium ion GO:0051592 81 47 1,000 0,0315579 0,09771984 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,0315579 0,09759423 ! positive regulation of cyclase activity GO:0031281 103 47 1,000 0,0315579 0,09746895 ! JNK cascade GO:0007254 91 47 1,000 0,0315579 0,09734399 ! methylation GO:0032259 90 47 1,000 0,0315579 0,09721935 ! protein homooligomerization GO:0051260 76 47 1,000 0,0315579 0,09709503 ! morphogenesis of embryonic epithelium GO:0016331 91 48 1,000 0,03280442 0,10080132 ! positive regulation of lyase activity GO:0051349 104 48 1,000 0,03280442 0,10067274 ! regulation of inflammatory response GO:0050727 75 48 1,000 0,03280442 0,1005445 ! regulation of protein complex disassembly GO:0043244 113 49 1,000 0,03407 0,10429062 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 1,000 0,03407 0,10415811 ! induction of apoptosis by extracellular signals GO:0008624 89 49 1,000 0,03407 0,10402593 ! response to temperature stimulus GO:0009266 76 49 1,000 0,03407 0,10389408 ! endocrine system development GO:0035270 104 49 1,000 0,03407 0,10376257 ! DNA-dependent DNA replication GO:0006261 74 49 1,000 0,03407 0,10363139 ! ribonucleoprotein complex assembly GO:0022618 95 49 1,000 0,03407 0,10350054 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,03407 0,10337003 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,0349447 0,10589035 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,0349447 0,10575716 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,0349447 0,1056243 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,0349447 0,10549177 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,0349447 0,10535957 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,0349447 0,10522771 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,0349447 0,10509617 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,0349447 0,10496497 ! sleep GO:0030431 13 6 0,000 0,0349447 0,10483409 ! response to oxygen radical GO:0000305 11 6 0,000 0,0349447 0,10470354 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,0349447 0,10457331 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,0349447 0,1044434 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,0349447 0,10431382 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,0349447 0,10418456 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,0349447 0,10405562 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,0349447 0,103927 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,0349447 0,10379869 ! forebrain regionalization GO:0021871 8 6 0,000 0,0349447 0,1036707 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,0349447 0,10354303 ! male meiosis GO:0007140 7 6 0,000 0,0349447 0,10341567 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,0349447 0,10328862 ! response to zinc ion GO:0010043 9 6 0,000 0,0349447 0,10316189 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,0349447 0,10303547 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,0349447 0,10290935 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,0349447 0,10278355 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,0349447 0,10265805 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,0349447 0,10253285 ! malate metabolic process GO:0006108 11 6 0,000 0,0349447 0,10240797 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,0349447 0,10228338 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,0349447 0,1021591 ! protein refolding GO:0042026 15 6 0,000 0,0349447 0,10203512 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,0349447 0,10191144 ! opsonization GO:0008228 8 6 0,000 0,0349447 0,10178806 ! mating behavior GO:0007617 7 6 0,000 0,0349447 0,10166498 ! erythrocyte maturation GO:0043249 7 6 0,000 0,0349447 0,1015422 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,0349447 0,10141971 ! equilibrioception GO:0050957 14 6 0,000 0,0349447 0,10129752 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,0349447 0,10117562 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,0349447 0,10105401 ! photoreceptor cell development GO:0042461 10 6 0,000 0,0349447 0,1009327 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,0349447 0,10081168 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,0349447 0,10069095 ! response to interferon-gamma GO:0034341 15 6 0,000 0,0349447 0,1005705 ! toxin metabolic process GO:0009404 11 6 0,000 0,0349447 0,10045035 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,0349447 0,10033048 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,0349447 0,10021089 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,0349447 0,1000916 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,0349447 0,09997258 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,0349447 0,09985385 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,0349447 0,0997354 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,0349447 0,09961723 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,0349447 0,09949934 ! thymic T cell selection GO:0045061 12 6 0,000 0,0349447 0,09938173 ! protein lipoylation GO:0009249 10 6 0,000 0,0349447 0,09926439 ! cysteine metabolic process GO:0006534 10 6 0,000 0,0349447 0,09914733 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,0349447 0,09903055 ! glutamate catabolic process GO:0006538 10 6 0,000 0,0349447 0,09891405 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,0349447 0,09879781 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,0349447 0,09868185 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,0349447 0,09856617 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,0349447 0,09845075 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,0349447 0,0983356 ! hyperosmotic response GO:0006972 9 6 0,000 0,0349447 0,09822072 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,0349447 0,09810611 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,0349447 0,09799177 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,0349447 0,09787769 ! urea metabolic process GO:0019627 7 6 0,000 0,0349447 0,09776388 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,0349447 0,09765034 ! neutrophil activation GO:0042119 8 6 0,000 0,0349447 0,09753705 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,0349447 0,09742403 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,0349447 0,09731127 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,0349447 0,09719877 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,0349447 0,09708654 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,0349447 0,09697456 ! nucleoside salvage GO:0043174 9 6 0,000 0,0349447 0,09686283 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,0349447 0,09675137 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,0349447 0,09664016 ! T cell mediated immunity GO:0002456 16 6 0,000 0,0349447 0,09652921 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,0349447 0,09641851 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 0,000 0,0349447 0,09630806 ! carnitine transport GO:0015879 10 6 0,000 0,0349447 0,09619787 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,0349447 0,09608793 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,0349447 0,09597824 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,0349447 0,0958688 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,0349447 0,09575961 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,0349447 0,09565067 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,0349447 0,09554198 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,0349447 0,09543353 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,0349447 0,09532533 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,0349447 0,09521737 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,0349447 0,09510966 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,0349447 0,09500219 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,0349447 0,09489497 ! interaction with symbiont GO:0051702 13 6 0,000 0,0349447 0,09478798 ! regulation of dendrite development GO:0050773 16 6 0,000 0,0349447 0,09468124 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,0349447 0,09457474 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,0349447 0,09446847 ! response to copper ion GO:0046688 10 6 0,000 0,0349447 0,09436245 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,0349447 0,09425666 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,0349447 0,09415111 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,0349447 0,09404579 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,0349447 0,09394071 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,0349447 0,09383587 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,0349447 0,09373126 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,0349447 0,09362688 ! hair follicle maturation GO:0048820 7 6 0,000 0,0349447 0,09352274 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,0349447 0,09341882 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,0349447 0,09331514 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,0349447 0,09321168 ! subpallium development GO:0021544 10 6 0,000 0,0349447 0,09310846 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,0349447 0,09300546 ! histone ubiquitination GO:0016574 8 6 0,000 0,0349447 0,0929027 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,0349447 0,09280015 ! maintenance of organ identity GO:0048496 9 6 0,000 0,0349447 0,09269784 ! G2 phase GO:0051319 16 6 0,000 0,0349447 0,09259575 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,0349447 0,09249388 ! establishment of planar polarity GO:0001736 7 6 0,000 0,0349447 0,09239224 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,0349447 0,09229082 ! membrane to membrane docking GO:0022614 14 6 0,000 0,0349447 0,09218963 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,0349447 0,09208865 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,0349447 0,0919879 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,0349447 0,09188737 ! receptor internalization GO:0031623 10 6 0,000 0,0349447 0,09178705 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,0349447 0,09168696 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,0349447 0,09158708 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0349447 0,09148742 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,0349447 0,09138798 ! protein deubiquitination GO:0016579 14 6 0,000 0,0349447 0,09128875 ! protein destabilization GO:0031648 9 6 0,000 0,0349447 0,09118974 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,0349447 0,09109094 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,0349447 0,09099236 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,0349447 0,09089399 ! progesterone metabolic process GO:0042448 10 6 0,000 0,0349447 0,09079583 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,0349447 0,09069789 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,0349447 0,09060015 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,0349447 0,09050263 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,0349447 0,09040531 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,0349447 0,09030821 ! determination of adult lifespan GO:0008340 15 6 0,000 0,0349447 0,09021131 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,0349447 0,09011462 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,0349447 0,09001814 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,0349447 0,08992186 ! catecholamine transport GO:0051937 9 6 0,000 0,0349447 0,08982579 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,0349447 0,08972993 ! sensory cilium assembly GO:0035058 10 6 0,000 0,0349447 0,08963426 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,0349447 0,08953881 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,0349447 0,08944355 ! maternal placenta development GO:0001893 12 6 0,000 0,0349447 0,0893485 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,0349447 0,08925365 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,0349447 0,089159 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,0349447 0,08906455 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,0349447 0,08897031 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,0349447 0,08887626 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,0349447 0,08878241 ! histone modification GO:0016570 91 50 1,000 0,03535439 0,08972856 ! regulation of gene expression, epigenetic GO:0040029 105 50 1,000 0,03535439 0,08963401 ! positive regulation of binding GO:0051099 78 51 1,000 0,03665732 0,0928395 ! viral infectious cycle GO:0019058 99 51 1,000 0,03665732 0,09274187 ! response to estrogen stimulus GO:0043627 93 51 1,000 0,03665732 0,09264446 ! chromatin remodeling GO:0006338 109 51 1,000 0,03665732 0,09254724 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 1,000 0,03665732 0,09245023 ! regulation of cell shape GO:0008360 125 51 1,000 0,03665732 0,09235343 ! membrane fusion GO:0006944 110 52 1,000 0,03797853 0,09558196 ! covalent chromatin modification GO:0016569 101 52 1,000 0,03797853 0,09548208 ! synapse organization GO:0050808 85 52 1,000 0,03797853 0,09538241 ! RNA catabolic process GO:0006401 93 53 1,000 0,03931776 0,0986429 ! cell maturation GO:0048469 100 53 1,000 0,03931776 0,09854014 ! tRNA transcription GO:0009304 14 7 0,000 0,04064958 0,10177201 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,04064958 0,10166621 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,04064958 0,10156064 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04064958 0,10145529 ! regulation of helicase activity GO:0051095 15 7 0,000 0,04064958 0,10135015 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,04064958 0,10124524 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,04064958 0,10114053 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04064958 0,10103605 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04064958 0,10093178 ! prostate gland development GO:0030850 13 7 0,000 0,04064958 0,10082773 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,04064958 0,10072389 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04064958 0,10062026 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04064958 0,10051685 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,04064958 0,10041365 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04064958 0,10031066 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,04064958 0,10020789 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,04064958 0,10010532 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,04064958 0,10000296 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,04064958 0,09990081 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04064958 0,09979887 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,04064958 0,09969714 ! glycolipid transport GO:0046836 10 7 0,000 0,04064958 0,09959562 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04064958 0,0994943 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,04064958 0,09939319 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04064958 0,09929228 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,04064958 0,09919158 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04064958 0,09909108 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,04064958 0,09899079 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,04064958 0,09889069 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,04064958 0,09879081 ! mRNA stabilization GO:0048255 18 7 0,000 0,04064958 0,09869112 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 14 7 0,000 0,04064958 0,09859163 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,04064958 0,09849234 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,04064958 0,09839326 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04064958 0,09829437 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04064958 0,09819568 ! lipoprotein transport GO:0042953 14 7 0,000 0,04064958 0,09809719 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04064958 0,0979989 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04064958 0,0979008 ! rhythmic behavior GO:0007622 15 7 0,000 0,04064958 0,0978029 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,04064958 0,09770519 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,04064958 0,09760768 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,04064958 0,09751037 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04064958 0,09741324 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,04064958 0,09731632 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04064958 0,09721958 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,04064958 0,09712304 ! mechanosensory behavior GO:0007638 14 7 0,000 0,04064958 0,09702668 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04064958 0,09693052 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,04064958 0,09683455 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04064958 0,09673877 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04064958 0,09664318 ! spinal cord patterning GO:0021511 13 7 0,000 0,04064958 0,09654778 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,04064958 0,09645256 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04064958 0,09635753 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,04064958 0,09626269 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,04064958 0,09616804 ! ovulation GO:0030728 9 7 0,000 0,04064958 0,09607357 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,04064958 0,09597929 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,04064958 0,09588519 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,04064958 0,09579128 ! microtubule nucleation GO:0007020 20 7 0,000 0,04064958 0,09569755 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04064958 0,09560401 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04064958 0,09551064 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,04064958 0,09541746 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,04064958 0,09532446 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,04064958 0,09523164 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04064958 0,09513901 ! galactose metabolic process GO:0006012 13 7 0,000 0,04064958 0,09504655 ! vesicle fusion GO:0006906 17 7 0,000 0,04064958 0,09495427 ! response to dietary excess GO:0002021 8 7 0,000 0,04064958 0,09486217 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04064958 0,09477025 ! intracellular pH reduction GO:0051452 11 7 0,000 0,04064958 0,09467851 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04064958 0,09458694 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,04064958 0,09449555 ! purine salvage GO:0043101 10 7 0,000 0,04064958 0,09440434 ! nucleoside transport GO:0015858 8 7 0,000 0,04064958 0,09431331 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,04064958 0,09422244 ! parturition GO:0007567 14 7 0,000 0,04064958 0,09413176 ! rRNA modification GO:0000154 14 7 0,000 0,04064958 0,09404125 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,04064958 0,09395091 ! spindle checkpoint GO:0031577 15 7 0,000 0,04064958 0,09386075 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,04064958 0,09377075 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,04064958 0,09368094 ! macrophage differentiation GO:0030225 11 7 0,000 0,04064958 0,09359129 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04064958 0,09350181 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04064958 0,09341251 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,04064958 0,09332338 ! G1 DNA damage checkpoint GO:0031571 21 7 0,000 0,04064958 0,09323441 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04064958 0,09314562 ! fibrinolysis GO:0042730 10 7 0,000 0,04064958 0,09305699 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 0,000 0,04064958 0,09296853 ! eating behavior GO:0042755 7 7 0,000 0,04064958 0,09288024 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04064958 0,09279212 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,04064958 0,09270417 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,04064958 0,09261638 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04064958 0,09252876 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,04064958 0,0924413 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04064958 0,09235401 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,04064958 0,09226688 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,04064958 0,09217992 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,04064958 0,09209312 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,04064958 0,09200649 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04064958 0,09192002 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,04064958 0,09183371 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,04064958 0,09174756 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04064958 0,09166157 ! regulation of meiosis GO:0040020 12 7 0,000 0,04064958 0,09157575 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,04064958 0,09149008 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,04064958 0,09140458 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04064958 0,09131923 ! oxygen homeostasis GO:0032364 12 7 0,000 0,04064958 0,09123405 ! transcription termination GO:0006353 13 7 0,000 0,04064958 0,09114902 ! response to tumor cell GO:0002347 13 7 0,000 0,04064958 0,09106415 ! regulation of respiratory burst GO:0060263 11 7 0,000 0,04064958 0,09097944 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04064958 0,09089489 ! anaphase GO:0051322 17 7 0,000 0,04064958 0,09081049 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,04064958 0,09072625 ! axonal fasciculation GO:0007413 18 7 0,000 0,04064958 0,09064217 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,04064958 0,09055824 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,04064958 0,09047447 ! diuresis GO:0030146 12 7 0,000 0,04064958 0,09039085 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04064958 0,09030738 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04064958 0,09022407 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04064958 0,09014092 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,04064958 0,09005792 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,04064958 0,08997507 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04064958 0,08989237 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04064958 0,08980982 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04064958 0,08972743 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04064958 0,08964519 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,04064958 0,08956309 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04064958 0,08948115 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,04064958 0,08939936 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,04064958 0,08931771 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,04064958 0,08923622 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04064958 0,08915487 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,04064958 0,08907368 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,04064958 0,08899263 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,04064958 0,08891172 ! adult feeding behavior GO:0008343 9 7 0,000 0,04064958 0,08883097 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,04064958 0,08875036 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,04064958 0,0886699 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04064958 0,08858958 ! muscle adaptation GO:0043500 14 7 0,000 0,04064958 0,08850941 ! embryonic heart tube development GO:0035050 10 7 0,000 0,04064958 0,08842938 ! retina homeostasis GO:0001895 12 7 0,000 0,04064958 0,0883495 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,04064958 0,08826976 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,04064958 0,08819017 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,04064958 0,08811072 ! protein prenylation GO:0018342 18 7 0,000 0,04064958 0,08803141 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,04064958 0,08795225 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,04064958 0,08787322 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04064958 0,08779434 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,04067476 0,08776992 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 1,000 0,04067476 0,08769128 ! cellular polysaccharide metabolic process GO:0044264 86 55 1,000 0,04204926 0,09057343 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,04204926 0,09049241 ! regulation of DNA replication GO:0006275 101 56 1,000 0,04344102 0,09340401 ! positive regulation of organelle organization GO:0010638 100 56 1,000 0,04344102 0,09332062 ! lipid modification GO:0030258 97 57 1,000 0,04484979 0,096261 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,04484979 0,09617521 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,04627532 0,09914373 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,04632093 0,09915317 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,04632093 0,09906504 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 0,000 0,04632093 0,09897706 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,04632093 0,09888923 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,04632093 0,09880157 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,04632093 0,09871405 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,04632093 0,0986267 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,04632093 0,09853949 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,04632093 0,09845244 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,04632093 0,09836555 ! meiotic prophase I GO:0007128 13 8 0,000 0,04632093 0,09827881 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,04632093 0,09819222 ! oligopeptide transport GO:0006857 15 8 0,000 0,04632093 0,09810578 ! UTP metabolic process GO:0046051 8 8 0,000 0,04632093 0,0980195 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,04632093 0,09793336 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,04632093 0,09784738 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,04632093 0,09776155 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,04632093 0,09767587 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04632093 0,09759034 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,04632093 0,09750496 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,04632093 0,09741973 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,04632093 0,09733464 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,04632093 0,09724971 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04632093 0,09716492 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,04632093 0,09708029 ! reflex GO:0060004 16 8 0,000 0,04632093 0,09699579 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,04632093 0,09691145 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,04632093 0,09682725 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,04632093 0,0967432 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,04632093 0,0966593 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,04632093 0,09657554 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,04632093 0,09649192 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,04632093 0,09640845 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,04632093 0,09632512 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,04632093 0,09624194 ! histidine metabolic process GO:0006547 16 8 0,000 0,04632093 0,0961589 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,04632093 0,09607601 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,04632093 0,09599325 ! glycine catabolic process GO:0006546 13 8 0,000 0,04632093 0,09591064 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,04632093 0,09582817 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,04632093 0,09574585 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,04632093 0,09566366 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,04632093 0,09558162 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04632093 0,09549972 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,04632093 0,09541795 ! macrophage activation GO:0042116 12 8 0,000 0,04632093 0,09533633 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,04632093 0,09525484 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,04632093 0,0951735 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,04632093 0,09509229 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,04632093 0,09501123 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,04632093 0,0949303 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04632093 0,0948495 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,04632093 0,09476885 ! osteoblast development GO:0002076 16 8 0,000 0,04632093 0,09468833 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,04632093 0,09460795 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,04632093 0,09452771 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,04632093 0,0944476 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,04632093 0,09436763 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,04632093 0,09428779 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,04632093 0,09420809 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,04632093 0,09412852 ! intermediate filament organization GO:0045109 12 8 0,000 0,04632093 0,09404909 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,04632093 0,09396979 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,04632093 0,09389062 ! cellular extravasation GO:0045123 12 8 0,000 0,04632093 0,09381159 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,04632093 0,09373269 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,04632093 0,09365392 ! response to antibiotic GO:0046677 11 8 0,000 0,04632093 0,09357529 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,04632093 0,09349678 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,04632093 0,09341841 ! DNA topological change GO:0006265 12 8 0,000 0,04632093 0,09334017 ! response to tropane GO:0014073 15 8 0,000 0,04632093 0,09326206 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,04632093 0,09318409 ! melanosome transport GO:0032402 13 8 0,000 0,04632093 0,09310624 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,04632093 0,09302852 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,04632093 0,09295093 ! mast cell activation GO:0045576 14 8 0,000 0,04632093 0,09287347 ! multicellular organismal aging GO:0010259 18 8 0,000 0,04632093 0,09279614 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,04632093 0,09271894 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,04632093 0,09264187 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,04632093 0,09256492 ! nucleosome disassembly GO:0006337 14 8 0,000 0,04632093 0,09248811 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,04632093 0,09241142 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,04632093 0,09233485 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04632093 0,09225842 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,04632093 0,09218211 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,04632093 0,09210592 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,04632093 0,09202987 ! intracellular lipid transport GO:0032365 13 8 0,000 0,04632093 0,09195393 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,04632093 0,09187813 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04632093 0,09180244 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,04632093 0,09172689 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,04632093 0,09165145 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,04632093 0,09157614 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,04632093 0,09150096 ! hormone catabolic process GO:0042447 17 8 0,000 0,04632093 0,0914259 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,04632093 0,09135096 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,04632093 0,09127614 ! ATP catabolic process GO:0006200 11 8 0,000 0,04632093 0,09120145 ! blastocyst growth GO:0001832 19 8 0,000 0,04632093 0,09112687 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,04632093 0,09105242 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,04632093 0,0909781 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,04632093 0,09090389 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,04632093 0,0908298 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04632093 0,09075584 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,04632093 0,09068199 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,04632093 0,09060827 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,04632093 0,09053466 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,04632093 0,09046117 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,04632093 0,09038781 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,04632093 0,09031456 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,04632093 0,09024143 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,04632093 0,09016842 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04632093 0,09009553 GO:0000076|DNA replication checkpoint, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,04632093 0,09002275 ! NAD biosynthetic process GO:0009435 13 8 0,000 0,04632093 0,08995009 ! skeletal system morphogenesis GO:0048705 105 59 1,000 0,04771736 0,09258707 ! cytokine-mediated signaling pathway GO:0019221 97 59 1,000 0,04771736 0,09251247 ! DNA damage response, signal transduction GO:0042770 128 60 1,000 0,04917568 0,09526303 ! camera-type eye development GO:0043010 116 60 1,000 0,04917568 0,09518639 ! regulation of developmental growth GO:0048638 15 9 0,000 0,05195895 0,10049294 ! axon extension GO:0048675 15 9 0,000 0,05195895 0,10041223 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,05195895 0,10033164 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,05195895 0,10025118 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,05195895 0,10017085 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,05195895 0,10009065 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,05195895 0,10001058 ! phosphate transport GO:0006817 19 9 0,000 0,05195895 0,09993063 ! reproductive behavior GO:0019098 19 9 0,000 0,05195895 0,09985082 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,05195895 0,09977113 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,05195895 0,09969156 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05195895 0,09961213 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,05195895 0,09953282 ! GTP metabolic process GO:0046039 9 9 0,000 0,05195895 0,09945364 ! RNA methylation GO:0001510 15 9 0,000 0,05195895 0,09937458 ! induction of positive chemotaxis GO:0050930 15 9 0,000 0,05195895 0,09929565 ! regulation of histone modification GO:0031056 12 9 0,000 0,05195895 0,09921684 ! regulation of glycolysis GO:0006110 21 9 0,000 0,05195895 0,09913816 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,05195895 0,09905961 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,05195895 0,09898117 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,05195895 0,09890287 ! chemosensory behavior GO:0007635 20 9 0,000 0,05195895 0,09882468 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,05195895 0,09874662 ! leukocyte degranulation GO:0043299 16 9 0,000 0,05195895 0,09866868 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,05195895 0,09859087 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,05195895 0,09851318 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,05195895 0,09843561 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,05195895 0,09835816 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,05195895 0,09828083 ! protein targeting to ER GO:0045047 22 9 0,000 0,05195895 0,09820363 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,05195895 0,09812655 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,05195895 0,09804959 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,05195895 0,09797274 ! endosome organization GO:0007032 17 9 0,000 0,05195895 0,09789602 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,05195895 0,09781942 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05195895 0,09774294 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,05195895 0,09766658 ! mannose metabolic process GO:0006013 13 9 0,000 0,05195895 0,09759034 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,05195895 0,09751421 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,05195895 0,09743821 ! receptor clustering GO:0043113 18 9 0,000 0,05195895 0,09736232 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,05195895 0,09728655 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,05195895 0,0972109 ! ruffle organization GO:0031529 15 9 0,000 0,05195895 0,09713537 ! retinol metabolic process GO:0042572 18 9 0,000 0,05195895 0,09705995 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,05195895 0,09698466 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,05195895 0,09690947 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,05195895 0,09683441 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,05195895 0,09675946 GO:0030204|chondroitin sulfate metabolic process, ! protein heterooligomerization GO:0051291 16 9 0,000 0,05195895 0,09668463 ! oligodendrocyte development GO:0014003 10 9 0,000 0,05195895 0,09660991 ! segment specification GO:0007379 13 9 0,000 0,05195895 0,09653531 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,05195895 0,09646082 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,05195895 0,09638645 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,05195895 0,09631219 ! response to amine stimulus GO:0014075 13 9 0,000 0,05195895 0,09623805 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,05195895 0,09616402 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,05195895 0,0960901 ! erythrocyte development GO:0048821 15 9 0,000 0,05195895 0,0960163 ! gas homeostasis GO:0033483 16 9 0,000 0,05195895 0,09594261 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,05195895 0,09586904 ! renal water homeostasis GO:0003091 14 9 0,000 0,05195895 0,09579557 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,05195895 0,09572222 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,05195895 0,09564898 ! icosanoid secretion GO:0032309 15 9 0,000 0,05195895 0,09557586 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,05195895 0,09550284 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,05195895 0,09542994 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,05195895 0,09535715 ! regulation of cell division GO:0051302 15 9 0,000 0,05195895 0,09528447 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,05195895 0,0952119 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,05195895 0,09513944 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,05195895 0,09506709 ! sterol catabolic process GO:0016127 11 9 0,000 0,05195895 0,09499485 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,05195895 0,09492272 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,05195895 0,0948507 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,05195895 0,09477879 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,05195895 0,09470699 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,05195895 0,09463529 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,05195895 0,09456371 ! musculoskeletal movement GO:0050881 14 9 0,000 0,05195895 0,09449223 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,05195895 0,09442086 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,05195895 0,0943496 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,05195895 0,09427845 ! purine base metabolic process GO:0006144 21 9 0,000 0,05195895 0,0942074 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,05195895 0,09413646 ! pigment granule transport GO:0051904 17 9 0,000 0,05195895 0,09406563 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,05195895 0,0939949 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,05195895 0,09392428 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,05195895 0,09385377 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05195895 0,09378336 ! mitochondrion localization GO:0051646 15 9 0,000 0,05195895 0,09371306 ! viral reproductive process GO:0022415 126 62 1,000 0,05214018 0,09396949 ! regulation of mitosis GO:0007088 105 63 1,000 0,05364589 0,09661078 GO:0051783|regulation of nuclear division, ! regulation of lipid metabolic process GO:0019216 115 63 1,000 0,05364589 0,09653852 ! detection of external stimulus GO:0009581 91 63 1,000 0,05364589 0,09646637 ! regulation of cytokine biosynthetic process GO:0042035 95 65 1,000 0,05670305 0,10188762 ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,05670305 0,10181159 GO:0035113|embryonic appendage morphogenesis, ! myeloid cell differentiation GO:0030099 111 65 1,000 0,05670305 0,10173567 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,05756381 0,10320308 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,05756381 0,10312623 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,05756381 0,1030495 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,05756381 0,10297288 ! synapsis GO:0007129 13 10 0,000 0,05756381 0,10289638 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,05756381 0,10281999 ! N-glycan processing GO:0006491 20 10 0,000 0,05756381 0,10274372 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,05756381 0,10266755 ! social behavior GO:0035176 24 10 0,000 0,05756381 0,1025915 ! smoothened signaling pathway GO:0007224 16 10 0,000 0,05756381 0,10251557 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,05756381 0,10243974 ! androgen metabolic process GO:0008209 17 10 0,000 0,05756381 0,10236403 ! phospholipid efflux GO:0033700 16 10 0,000 0,05756381 0,10228843 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,05756381 0,10221294 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,05756381 0,10213756 ! lung alveolus development GO:0048286 26 10 0,000 0,05756381 0,10206229 ! pathogenesis GO:0009405 13 10 0,000 0,05756381 0,10198714 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05756381 0,10191209 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,05756381 0,10183715 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,05756381 0,10176233 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,05756381 0,10168761 ! endoderm development GO:0007492 16 10 0,000 0,05756381 0,10161301 ! arginine catabolic process GO:0006527 13 10 0,000 0,05756381 0,10153851 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,05756381 0,10146412 ! proline metabolic process GO:0006560 13 10 0,000 0,05756381 0,10138985 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,05756381 0,10131568 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,05756381 0,10124162 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,05756381 0,10116766 ! V(D)J recombination GO:0033151 28 10 0,000 0,05756381 0,10109382 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05756381 0,10102008 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,05756381 0,10094645 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,05756381 0,10087293 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,05756381 0,10079951 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,05756381 0,1007262 ! multicellular organism growth GO:0035264 18 10 0,000 0,05756381 0,100653 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,05756381 0,10057991 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,05756381 0,10050692 ! epithelial cell development GO:0002064 20 10 0,000 0,05756381 0,10043403 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,05756381 0,10036125 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,05756381 0,10028858 ! macroautophagy GO:0016236 17 10 0,000 0,05756381 0,10021601 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,05756381 0,10014355 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,05756381 0,10007119 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,05756381 0,09999894 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,05756381 0,09992679 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 0,000 0,05756381 0,09985474 ! copper ion homeostasis GO:0055070 13 10 0,000 0,05756381 0,0997828 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,05756381 0,09971096 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,05756381 0,09963923 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 0,000 0,05756381 0,0995676 ! blastoderm segmentation GO:0007350 18 10 0,000 0,05756381 0,09949607 ! response to dsRNA GO:0043331 20 10 0,000 0,05756381 0,09942464 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05756381 0,09935332 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,05756381 0,0992821 ! melanosome localization GO:0032400 16 10 0,000 0,05756381 0,09921098 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,05756381 0,09913996 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,05756381 0,09906905 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,05756381 0,09899823 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,05756381 0,09892752 ! mRNA cleavage GO:0006379 17 10 0,000 0,05756381 0,09885691 ! protein sumoylation GO:0016925 15 10 0,000 0,05756381 0,0987864 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,05756381 0,09871599 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,05756381 0,09864568 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,05756381 0,09857547 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,05756381 0,09850536 ! salivary gland development GO:0007431 27 10 0,000 0,05756381 0,09843534 ! prophase GO:0051324 15 10 0,000 0,05756381 0,09836543 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05756381 0,09829562 ! apical protein localization GO:0045176 15 10 0,000 0,05756381 0,09822591 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,05756381 0,09815629 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,05756381 0,09808678 ! positive regulation of leukocyte migration GO:0002687 25 10 0,000 0,05756381 0,09801736 ! midbrain development GO:0030901 13 10 0,000 0,05756381 0,09794804 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05756381 0,09787882 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,05756381 0,0978097 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,05756381 0,09774067 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,05756381 0,09767174 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,05756381 0,09760291 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,05756381 0,09753418 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,05756381 0,09746554 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 0,000 0,05756381 0,097397 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 23 10 0,000 0,05756381 0,09732855 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,05756381 0,0972602 ! blastocyst formation GO:0001825 17 10 0,000 0,05756381 0,09719195 ! cerebellar cortex development GO:0021695 15 10 0,000 0,05756381 0,09712379 ! activation of innate immune response GO:0002218 12 10 0,000 0,05756381 0,09705573 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,05756381 0,09698777 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,05756381 0,09691989 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,05756381 0,09685212 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,05756381 0,09678444 ! secondary metabolic process GO:0019748 116 66 1,000 0,05825404 0,09787655 ! developmental maturation GO:0021700 116 66 1,000 0,05825404 0,09780824 ! cell projection assembly GO:0030031 120 66 1,000 0,05825404 0,09774004 ! regulation of cellular response to stress GO:0080135 128 67 1,000 0,05981967 0,10029695 ! lung development GO:0030324 144 67 1,000 0,05981967 0,1002271 ! chromosome segregation GO:0007059 113 67 1,000 0,05981967 0,10015736 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 1,000 0,05981967 0,1000877 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,05981967 0,10001815 ! viral reproduction GO:0016032 134 68 1,000 0,06139971 0,10258868 ! regulation of lipase activity GO:0060191 130 68 1,000 0,06139971 0,10251749 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 1,000 0,06139971 0,1024464 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 1,000 0,06299394 0,10503356 ! respiratory burst GO:0045730 17 11 0,000 0,06313573 0,10519706 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,06313573 0,10512426 ! neuron fate specification GO:0048665 17 11 0,000 0,06313573 0,10505156 ! telencephalon cell migration GO:0022029 20 11 0,000 0,06313573 0,10497896 ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,06313573 0,10490646 ! thyroid gland development GO:0030878 26 11 0,000 0,06313573 0,10483406 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,06313573 0,10476176 ! response to pain GO:0048265 24 11 0,000 0,06313573 0,10468956 ! blood vessel remodeling GO:0001974 29 11 0,000 0,06313573 0,10461746 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 0,000 0,06313573 0,10454546 ! bone resorption GO:0045453 16 11 0,000 0,06313573 0,10447356 ! ventral spinal cord development GO:0021517 21 11 0,000 0,06313573 0,10440176 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,06313573 0,10433005 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,06313573 0,10425845 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,06313573 0,10418694 ! melanocyte differentiation GO:0030318 21 11 0,000 0,06313573 0,10411553 GO:0050931|pigment cell differentiation, ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,06313573 0,10404422 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,06313573 0,103973 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,06313573 0,10390189 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of intracellular pH GO:0051453 19 11 0,000 0,06313573 0,10383087 ! lipid digestion GO:0044241 18 11 0,000 0,06313573 0,10375994 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,06313573 0,10368912 ! UV protection GO:0009650 19 11 0,000 0,06313573 0,10361839 ! adult heart development GO:0007512 14 11 0,000 0,06313573 0,10354776 ! chondrocyte differentiation GO:0002062 24 11 0,000 0,06313573 0,10347722 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,06313573 0,10340678 ! temperature homeostasis GO:0001659 17 11 0,000 0,06313573 0,10333643 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,06313573 0,10326618 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,06313573 0,10319603 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,06313573 0,10312597 ! regulation of organ growth GO:0046620 13 11 0,000 0,06313573 0,10305601 ! pigment granule localization GO:0051875 20 11 0,000 0,06313573 0,10298614 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,06313573 0,10291637 ! vasoconstriction GO:0042310 18 11 0,000 0,06313573 0,10284669 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,06313573 0,1027771 ! embryonic axis specification GO:0000578 18 11 0,000 0,06313573 0,10270761 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,06313573 0,10263821 ! snRNA metabolic process GO:0016073 24 11 0,000 0,06313573 0,10256891 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,06313573 0,1024997 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,06313573 0,10243058 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,06313573 0,10236156 ! zymogen activation GO:0031638 15 11 0,000 0,06313573 0,10229263 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,06313573 0,10222379 ! neuroblast proliferation GO:0007405 24 11 0,000 0,06313573 0,10215505 ! nucleosome positioning GO:0016584 15 11 0,000 0,06313573 0,1020864 ! regulation of isotype switching GO:0045191 22 11 0,000 0,06313573 0,10201784 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,06313573 0,10194937 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,06313573 0,10188099 ! regulation of leukocyte migration GO:0002685 26 11 0,000 0,06313573 0,10181271 ! acid secretion GO:0046717 18 11 0,000 0,06313573 0,10174451 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,06313573 0,10167641 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,06313573 0,1016084 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,06313573 0,10154048 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,06313573 0,10147265 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,06313573 0,10140491 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 19 11 0,000 0,06313573 0,10133726 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,06313573 0,1012697 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,06313573 0,10120224 ! negative regulation of glucose import GO:0046325 17 11 0,000 0,06313573 0,10113486 GO:0010829|negative regulation of glucose transport, ! embryonic gut development GO:0048566 15 11 0,000 0,06313573 0,10106757 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,06313573 0,10100037 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,06313573 0,10093326 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,06313573 0,10086624 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,06313573 0,10079931 ! defense response to fungus GO:0050832 13 11 0,000 0,06313573 0,10073246 ! developmental induction GO:0031128 19 11 0,000 0,06313573 0,10066571 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,06313573 0,10059904 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,06313573 0,10053247 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,06313573 0,10046598 ! sequestering of metal ion GO:0051238 14 11 0,000 0,06313573 0,10039957 ! lamellipodium assembly GO:0030032 20 11 0,000 0,06313573 0,10033326 ! regulation of embryonic development GO:0045995 27 11 0,000 0,06313573 0,10026703 ! nucleus localization GO:0051647 19 11 0,000 0,06313573 0,1002009 ! regulation of synapse organization GO:0050807 17 11 0,000 0,06313573 0,10013484 ! appendage morphogenesis GO:0035107 135 70 1,000 0,06460215 0,10239312 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 150 70 1,000 0,06460215 0,10232572 ! appendage development GO:0048736 136 71 1,000 0,0662241 0,10482578 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 1,000 0,0662241 0,10475686 ! B cell activation GO:0042113 160 71 1,000 0,0662241 0,10468803 ! regulation of MAPKKK cascade GO:0043408 142 71 1,000 0,0662241 0,10461929 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,06785959 0,10713265 ! carbohydrate transport GO:0008643 110 72 1,000 0,06785959 0,1070624 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 1,000 0,06785959 0,10699224 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 1,000 0,06785959 0,10692218 ! respiratory system development GO:0060541 153 72 1,000 0,06785959 0,1068522 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,06867488 0,10806525 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,06867488 0,10799462 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,06867488 0,10792408 ! positive regulation of cellular catabolic process GO:0031331 31 12 0,000 0,06867488 0,10785363 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,06867488 0,10778328 ! virus-host interaction GO:0019048 29 12 0,000 0,06867488 0,10771302 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,06867488 0,10764285 ! cartilage condensation GO:0001502 20 12 0,000 0,06867488 0,10757277 ! regulation of positive chemotaxis GO:0050926 19 12 0,000 0,06867488 0,10750278 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,06867488 0,10743288 ! protein complex disassembly GO:0043241 27 12 0,000 0,06867488 0,10736307 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,06867488 0,10729336 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,06867488 0,10722373 ! hippocampus development GO:0021766 26 12 0,000 0,06867488 0,10715419 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,06867488 0,10708475 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,06867488 0,10701539 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,06867488 0,10694613 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,06867488 0,10687695 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,06867488 0,10680786 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,06867488 0,10673887 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,06867488 0,10666996 ! drug transport GO:0015893 16 12 0,000 0,06867488 0,10660114 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,06867488 0,10653241 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,06867488 0,10646377 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,06867488 0,10639521 ! polyamine metabolic process GO:0006595 17 12 0,000 0,06867488 0,10632675 ! mitotic spindle organization GO:0007052 21 12 0,000 0,06867488 0,10625837 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,06867488 0,10619008 ! forebrain cell migration GO:0021885 21 12 0,000 0,06867488 0,10612188 ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,06867488 0,10605377 ! entry into host cell GO:0030260 32 12 0,000 0,06867488 0,10598574 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,06867488 0,1059178 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06867488 0,10584995 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,06867488 0,10578218 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,06867488 0,1057145 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,06867488 0,10564691 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,06867488 0,1055794 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,06867488 0,10551198 ! protein homotetramerization GO:0051289 21 12 0,000 0,06867488 0,10544465 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,06867488 0,1053774 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,06867488 0,10531024 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06867488 0,10524316 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,06867488 0,10517617 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,06867488 0,10510927 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,06867488 0,10504245 ! cranial nerve development GO:0021545 20 12 0,000 0,06867488 0,10497571 ! fucose catabolic process GO:0019317 22 12 0,000 0,06867488 0,10490906 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,06867488 0,10484249 ! histone methylation GO:0016571 26 12 0,000 0,06867488 0,10477601 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,06867488 0,10470961 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,06867488 0,1046433 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,06867488 0,10457707 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,06867488 0,10451092 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,06867488 0,10444486 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,06867488 0,10437888 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,06867488 0,10431298 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,06867488 0,10424717 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,06867488 0,10418144 ! response to cold GO:0009409 17 12 0,000 0,06867488 0,1041158 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,06867488 0,10405023 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,06867488 0,10398475 ! eye development GO:0001654 143 74 1,000 0,07117031 0,10769544 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 1,000 0,07284512 0,1101605 ! cGMP metabolic process GO:0046068 18 13 0,000 0,07418147 0,11211094 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 18 13 0,000 0,07418147 0,11204057 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,07418147 0,11197028 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,07418147 0,11190008 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,07418147 0,11182996 ! organelle fusion GO:0048284 32 13 0,000 0,07418147 0,11175994 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,07418147 0,11169 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,07418147 0,11162015 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,07418147 0,11155039 ! endocrine pancreas development GO:0031018 22 13 0,000 0,07418147 0,11148071 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,07418147 0,11141112 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,07418147 0,11134162 ! methionine metabolic process GO:0006555 27 13 0,000 0,07418147 0,11127221 ! plasma membrane organization GO:0007009 24 13 0,000 0,07418147 0,11120288 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,07418147 0,11113364 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,07418147 0,11106448 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,07418147 0,11099541 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,07418147 0,11092643 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,07418147 0,11085753 ! response to X-ray GO:0010165 25 13 0,000 0,07418147 0,11078872 ! cytokine metabolic process GO:0042107 22 13 0,000 0,07418147 0,11071999 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,07418147 0,11065135 ! exocrine system development GO:0035272 32 13 0,000 0,07418147 0,11058279 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 0,000 0,07418147 0,11051432 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,07418147 0,11044593 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,07418147 0,11037763 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,07418147 0,11030941 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,07418147 0,11024127 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,07418147 0,11017322 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,07418147 0,11010526 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,07418147 0,11003737 ! regulation of cellular pH GO:0030641 22 13 0,000 0,07418147 0,10996958 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,07418147 0,10990186 ! ribosome assembly GO:0042255 17 13 0,000 0,07418147 0,10983423 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,07418147 0,10976668 ! chromatin silencing GO:0006342 26 13 0,000 0,07418147 0,10969921 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,07418147 0,10963183 ! regulation of epidermis development GO:0045682 19 13 0,000 0,07418147 0,10956453 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07418147 0,10949731 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,07418147 0,10943018 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,07418147 0,10936313 ! regulation of mRNA stability GO:0043488 31 13 0,000 0,07418147 0,10929615 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,07418147 0,10922927 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,07418147 0,10916246 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,07418147 0,10909573 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,07418147 0,10902909 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,07418147 0,10896253 ! embryonic placenta development GO:0001892 23 13 0,000 0,07418147 0,10889605 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,07418147 0,10882965 ! insulin secretion GO:0030073 23 13 0,000 0,07418147 0,10876333 ! actin filament polymerization GO:0030041 24 13 0,000 0,07418147 0,10869709 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,07418147 0,10863093 ! acrosome reaction GO:0007340 18 13 0,000 0,07418147 0,10856485 ! cytosolic calcium ion homeostasis GO:0051480 135 76 1,000 0,07453262 0,10901245 ! positive regulation of ligase activity GO:0051351 124 77 1,000 0,0762326 0,11143112 ! response to steroid hormone stimulus GO:0048545 137 78 1,000 0,07794485 0,1138648 ! protein oligomerization GO:0051259 139 78 1,000 0,07794485 0,1137957 ! rRNA transcription GO:0009303 25 14 0,000 0,07965568 0,11622291 ! reproductive cellular process GO:0048610 20 14 0,000 0,07965568 0,11615247 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,07965568 0,11608212 ! regulation of S phase GO:0033261 23 14 0,000 0,07965568 0,11601185 ! water transport GO:0006833 21 14 0,000 0,07965568 0,11594167 GO:0042044|fluid transport, ! non-recombinational repair GO:0000726 25 14 0,000 0,07965568 0,11587157 GO:0006303|double-strand break repair via nonhomologous end joining, ! retina development in camera-type eye GO:0060041 27 14 0,000 0,07965568 0,11580156 ! RNA polyadenylation GO:0043631 30 14 0,000 0,07965568 0,11573163 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,07965568 0,11566178 ! palate development GO:0060021 31 14 0,000 0,07965568 0,11559202 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 0,000 0,07965568 0,11552235 ! regulated secretory pathway GO:0045055 23 14 0,000 0,07965568 0,11545276 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,07965568 0,11538325 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,07965568 0,11531382 ! arginine metabolic process GO:0006525 17 14 0,000 0,07965568 0,11524448 ! regulation of heart rate GO:0002027 24 14 0,000 0,07965568 0,11517523 ! organic alcohol transport GO:0015850 29 14 0,000 0,07965568 0,11510605 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,07965568 0,11503696 ! embryo implantation GO:0007566 30 14 0,000 0,07965568 0,11496795 ! neutral amino acid transport GO:0015804 26 14 0,000 0,07965568 0,11489903 ! L-amino acid transport GO:0015807 30 14 0,000 0,07965568 0,11483018 ! bone mineralization GO:0030282 17 14 0,000 0,07965568 0,11476142 ! stem cell development GO:0048864 43 14 0,000 0,07965568 0,11469274 GO:0019827|stem cell maintenance, ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07965568 0,11462415 ! cerebellum development GO:0021549 21 14 0,000 0,07965568 0,11455563 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,07965568 0,1144872 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,07965568 0,11441885 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,07965568 0,11435058 ! cofactor transport GO:0051181 26 14 0,000 0,07965568 0,1142824 ! NADP metabolic process GO:0006739 24 14 0,000 0,07965568 0,11421429 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,07965568 0,11414626 ! intestinal absorption GO:0050892 25 14 0,000 0,07965568 0,11407832 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,07965568 0,11401046 ! oxygen transport GO:0015671 21 14 0,000 0,07965568 0,11394267 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,07965568 0,11387497 ! male genitalia development GO:0030539 24 14 0,000 0,07965568 0,11380735 ! regulation of RNA stability GO:0043487 32 14 0,000 0,07965568 0,11373981 ! regulation of axon extension GO:0030516 37 14 0,000 0,07965568 0,11367235 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,07965568 0,11360497 ! activation of protein kinase activity GO:0032147 147 79 1,000 0,07966919 0,11355691 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,07966919 0,11348968 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,08140539 0,1158943 ! protein import into nucleus GO:0006606 158 80 1,000 0,08140539 0,11582577 ! nuclear import GO:0051170 161 81 1,000 0,08315327 0,11824278 ! regulation of neuron differentiation GO:0045664 167 81 1,000 0,08315327 0,11817293 ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,08491263 0,12060201 ! response to nutrient GO:0007584 125 82 1,000 0,08491263 0,12053085 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,08491263 0,12045979 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,08509771 0,1206512 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,08509771 0,12058015 ! superoxide anion generation GO:0042554 20 15 0,000 0,08509771 0,12050918 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,08509771 0,12043829 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,08509771 0,12036748 ! copper ion transport GO:0006825 20 15 0,000 0,08509771 0,12029676 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,08509771 0,12022612 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,08509771 0,12015557 ! sulfate transport GO:0008272 23 15 0,000 0,08509771 0,1200851 ! response to cAMP GO:0051591 22 15 0,000 0,08509771 0,12001471 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,08509771 0,1199444 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,08509771 0,11987417 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,08509771 0,11980403 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,08509771 0,11973397 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,08509771 0,11966399 ! response to hexose stimulus GO:0009746 22 15 0,000 0,08509771 0,11959409 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,08509771 0,11952428 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,08509771 0,11945454 ! pituitary gland development GO:0021983 29 15 0,000 0,08509771 0,11938489 ! regulation of the force of heart contraction GO:0002026 26 15 0,000 0,08509771 0,11931532 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,08509771 0,11924583 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 0,000 0,08509771 0,11917642 ! regulation of exocytosis GO:0017157 22 15 0,000 0,08509771 0,11910709 ! G1/S transition checkpoint GO:0031575 40 15 0,000 0,08509771 0,11903784 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,08509771 0,11896867 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,08509771 0,11889959 ! regulation of vasodilation GO:0042312 26 15 0,000 0,08509771 0,11883058 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,08509771 0,11876165 ! histone deacetylation GO:0016575 20 15 0,000 0,08509771 0,11869281 ! mRNA splice site selection GO:0006376 38 15 0,000 0,08509771 0,11862404 ! tissue regeneration GO:0042246 26 15 0,000 0,08509771 0,11855535 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,08509771 0,11848674 ! water homeostasis GO:0030104 27 15 0,000 0,08509771 0,11841821 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,08509771 0,11834976 ! muscle maintenance GO:0046716 26 15 0,000 0,08509771 0,11828139 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,08509771 0,1182131 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,08509771 0,11814489 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,08509771 0,11807675 ! dopamine metabolic process GO:0042417 35 15 0,000 0,08509771 0,1180087 ! heme biosynthetic process GO:0006783 29 15 0,000 0,08509771 0,11794072 ! cell killing GO:0001906 29 15 0,000 0,08509771 0,11787282 ! detection of bacterium GO:0016045 18 15 0,000 0,08509771 0,117805 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,08509771 0,11773726 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,08509771 0,11766959 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,08509771 0,117602 ! peptide hormone processing GO:0016486 23 15 0,000 0,08509771 0,11753449 ! regulation of lyase activity GO:0051339 160 83 1,000 0,08668328 0,11965575 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,08846501 0,12204519 ! negative regulation of transport GO:0051051 153 84 1,000 0,08846501 0,12197525 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,08846501 0,1219054 ! nucleosome assembly GO:0006334 122 85 1,000 0,09025765 0,12430446 ! one-carbon metabolic process GO:0006730 154 85 1,000 0,09025765 0,12423335 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,09050774 0,12450635 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,09050774 0,12443521 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,09050774 0,12436414 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,09050774 0,12429316 ! bone remodeling GO:0046849 27 16 0,000 0,09050774 0,12422225 ! filopodium assembly GO:0046847 32 16 0,000 0,09050774 0,12415143 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,09050774 0,12408069 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,09050774 0,12401003 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,09050774 0,12393945 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,09050774 0,12386895 ! startle response GO:0001964 28 16 0,000 0,09050774 0,12379853 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,09050774 0,12372819 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,09050774 0,12365793 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,09050774 0,12358775 ! protein polyubiquitination GO:0000209 34 16 0,000 0,09050774 0,12351765 ! glutamate metabolic process GO:0006536 22 16 0,000 0,09050774 0,12344763 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,09050774 0,12337768 ! response to osmotic stress GO:0006970 25 16 0,000 0,09050774 0,12330782 ! lysosomal transport GO:0007041 26 16 0,000 0,09050774 0,12323804 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,09050774 0,12316833 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,09050774 0,12309871 ! negative regulation of immune response GO:0050777 35 16 0,000 0,09050774 0,12302916 ! axon cargo transport GO:0008088 43 16 0,000 0,09050774 0,12295969 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,09050774 0,1228903 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,09050774 0,12282099 ! DNA replication initiation GO:0006270 27 16 0,000 0,09050774 0,12275175 ! neuron recognition GO:0008038 35 16 0,000 0,09050774 0,1226826 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,09050774 0,12261352 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,09050774 0,12254452 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,09050774 0,1224756 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,09050774 0,12240675 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,09050774 0,12233798 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,09050774 0,12226929 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,09050774 0,12220068 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,09050774 0,12213214 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,09050774 0,12206368 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,09050774 0,1219953 ! chromatin assembly GO:0031497 124 86 1,000 0,09206099 0,12401945 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,09387486 0,12639223 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein localization in nucleus GO:0034504 176 87 1,000 0,09387486 0,12632154 ! regulation of neurological system process GO:0031644 148 88 1,000 0,09569906 0,12870427 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,09588595 0,12888357 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,09588595 0,12881161 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,09588595 0,12873973 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,09588595 0,12866793 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,09588595 0,12859621 ! signal complex assembly GO:0007172 41 17 0,000 0,09588595 0,12852457 ! inositol metabolic process GO:0006020 28 17 0,000 0,09588595 0,128453 ! gene silencing by RNA GO:0031047 36 17 0,000 0,09588595 0,12838152 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,09588595 0,12831012 ! limbic system development GO:0021761 36 17 0,000 0,09588595 0,1282388 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,09588595 0,12816755 ! adult walking behavior GO:0007628 33 17 0,000 0,09588595 0,12809639 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,09588595 0,1280253 ! heart looping GO:0001947 30 17 0,000 0,09588595 0,1279543 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,09588595 0,12788337 ! myoblast differentiation GO:0045445 45 17 0,000 0,09588595 0,12781252 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,09588595 0,12774175 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 0,000 0,09588595 0,12767105 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,09588595 0,12760044 ! glycine metabolic process GO:0006544 28 17 0,000 0,09588595 0,1275299 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,09588595 0,12745945 ! NAD metabolic process GO:0019674 29 17 0,000 0,09588595 0,12738906 ! DNA integration GO:0015074 29 17 0,000 0,09588595 0,12731876 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,09588595 0,12724854 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,09588595 0,12717839 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,09588595 0,12710832 ! genitalia development GO:0048806 30 17 0,000 0,09588595 0,12703832 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,09588595 0,12696841 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 0,000 0,09588595 0,12689857 ! neutrophil chemotaxis GO:0030593 27 17 0,000 0,09588595 0,1268288 ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,09588595 0,12675912 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,09588595 0,12668951 ! steroid catabolic process GO:0006706 31 17 0,000 0,09588595 0,12661998 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,09588595 0,12655052 ! gas transport GO:0015669 25 17 0,000 0,09588595 0,12648114 ! organic cation transport GO:0015695 31 17 0,000 0,09588595 0,12641183 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,09588595 0,1263426 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,09588595 0,12627345 ! microspike assembly GO:0030035 36 17 0,000 0,09588595 0,12620437 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,09588595 0,12613537 ! regulation of cell morphogenesis GO:0022604 215 89 1,000 0,09753342 0,12823246 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,09937775 0,13058594 ! protein-DNA complex assembly GO:0065004 130 90 1,000 0,09937775 0,13051466 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,10123254 0,13287806 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,10123254 0,13280561 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,10123254 0,13273324 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,10123254 0,13266094 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,10123254 0,13258872 ! memory GO:0007613 31 18 0,000 0,10123254 0,13251659 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,10123254 0,13244453 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,10123254 0,13237255 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,10123254 0,13230064 GO:0042744|hydrogen peroxide catabolic process, ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,10123254 0,13222882 ! glutamine metabolic process GO:0006541 29 18 0,000 0,10123254 0,13215707 ! response to retinoic acid GO:0032526 26 18 0,000 0,10123254 0,1320854 ! response to fungus GO:0009620 21 18 0,000 0,10123254 0,13201381 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,10123254 0,1319423 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,10123254 0,13187086 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,10123254 0,13179951 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,10123254 0,13172822 ! vitamin transport GO:0051180 27 18 0,000 0,10123254 0,13165702 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,10123254 0,13158589 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,10123254 0,13151484 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,10123254 0,13144387 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,10123254 0,13137297 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 0,000 0,10123254 0,13130215 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,10123254 0,1312314 ! nerve development GO:0021675 28 18 0,000 0,10123254 0,13116074 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,10123254 0,13109014 ! regulation of defense response GO:0031347 149 92 1,000 0,1030956 0,13343088 ! nucleosome organization GO:0034728 138 92 1,000 0,1030956 0,13335915 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 1,000 0,10496877 0,13570922 GO:0010498|proteasomal protein catabolic process, ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,10496877 0,13563633 ! negative regulation of multicellular organismal process GO:0051241 166 93 1,000 0,10496877 0,13556353 ! protein secretion GO:0009306 39 19 0,000 0,10654769 0,13752883 ! positive regulation of translation GO:0045727 30 19 0,000 0,10654769 0,13745508 ! negative regulation of defense response GO:0031348 25 19 0,000 0,10654769 0,13738142 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,10654769 0,13730784 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,10654769 0,13723433 ! skin development GO:0043588 36 19 0,000 0,10654769 0,1371609 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,10654769 0,13708756 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,10654769 0,13701429 ! bile acid metabolic process GO:0008206 29 19 0,000 0,10654769 0,1369411 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,10654769 0,13686798 ! pigmentation during development GO:0048066 41 19 0,000 0,10654769 0,13679495 ! response to vitamin A GO:0033189 27 19 0,000 0,10654769 0,13672199 ! heme metabolic process GO:0042168 36 19 0,000 0,10654769 0,13664911 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,10654769 0,13657631 ! peptide cross-linking GO:0018149 37 19 0,000 0,10654769 0,13650358 ! protein export from nucleus GO:0006611 36 19 0,000 0,10654769 0,13643094 ! heart process GO:0003015 30 19 0,000 0,10654769 0,13635837 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,10654769 0,13628587 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,10654769 0,13621346 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,10654769 0,13614112 ! cell-cell junction organization GO:0045216 35 19 0,000 0,10654769 0,13606886 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,10654769 0,13599667 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,10654769 0,13592457 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,10654769 0,13585253 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,10654769 0,13578058 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,10654769 0,1357087 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,10654769 0,13563689 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,10654769 0,13556517 ! cilium assembly GO:0042384 37 19 0,000 0,10654769 0,13549351 ! peptide hormone secretion GO:0030072 31 19 0,000 0,10654769 0,13542194 ! transcription initiation GO:0006352 153 94 1,000 0,1068512 0,135736 ! regulation of Rho protein signal transduction GO:0035023 213 95 1,000 0,10874271 0,13806594 ! detection of stimulus GO:0051606 151 96 1,000 0,11064314 0,14040475 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,11183157 0,14183804 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,11183157 0,14176331 ! positive regulation of ossification GO:0045778 47 20 0,000 0,11183157 0,14168866 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,11183157 0,14161409 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,11183157 0,14153959 ! cAMP metabolic process GO:0046058 36 20 0,000 0,11183157 0,14146518 ! response to vitamin GO:0033273 31 20 0,000 0,11183157 0,14139084 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,11183157 0,14131658 ! regulation of carbohydrate metabolic process GO:0006109 38 20 0,000 0,11183157 0,1412424 GO:0010675|regulation of cellular carbohydrate metabolic process, ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,11183157 0,14116829 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,11183157 0,14109427 ! retinoid metabolic process GO:0001523 32 20 0,000 0,11183157 0,14102032 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,11183157 0,14094645 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,11183157 0,14087265 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,11183157 0,14079894 ! cellular response to starvation GO:0009267 33 20 0,000 0,11183157 0,1407253 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,11183157 0,14065173 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,11183157 0,14057825 ! body fluid secretion GO:0007589 31 20 0,000 0,11183157 0,14050484 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,11183157 0,14043151 ! peptide secretion GO:0002790 35 20 0,000 0,11183157 0,14035825 ! stem cell differentiation GO:0048863 53 20 0,000 0,11183157 0,14028507 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,11183157 0,14021197 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,11183157 0,14013894 ! sensory perception of pain GO:0019233 30 20 0,000 0,11183157 0,14006599 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,11183157 0,13999312 ! diencephalon development GO:0021536 34 20 0,000 0,11183157 0,13992032 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,11183157 0,13984759 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,11183157 0,13977494 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,11183157 0,13970237 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,11183157 0,13962987 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,11183157 0,13955745 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,11183157 0,13948511 ! regulation of glucose import GO:0046324 29 20 0,000 0,11183157 0,13941283 GO:0010827|regulation of glucose transport, ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,11183157 0,13934064 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,11183157 0,13926851 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,11183157 0,13919647 ! negative regulation of translation GO:0017148 29 20 0,000 0,11183157 0,13912449 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,11183157 0,13905259 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 0,000 0,11183157 0,13898077 ! Golgi vesicle transport GO:0048193 207 99 1,000 0,11639624 0,14457892 ! regulation of cell killing GO:0031341 42 21 0,000 0,11708439 0,14535864 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,11708439 0,14528367 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,11708439 0,14520878 ! hormone secretion GO:0046879 38 21 0,000 0,11708439 0,14513397 ! glycerol metabolic process GO:0006071 34 21 0,000 0,11708439 0,14505924 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,11708439 0,14498458 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,11708439 0,14491 ! axis specification GO:0009798 38 21 0,000 0,11708439 0,1448355 ! inactivation of MAPK activity GO:0000188 39 21 0,000 0,11708439 0,14476107 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,11708439 0,14468672 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,11708439 0,14461244 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,11708439 0,14453825 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,11708439 0,14446412 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,11708439 0,14439008 ! cytolysis GO:0019835 24 21 0,000 0,11708439 0,14431611 ! vasodilation GO:0042311 39 21 0,000 0,11708439 0,14424221 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,11708439 0,14416839 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,11708439 0,14409465 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,11708439 0,14402098 ! positive regulation of locomotion GO:0040017 39 21 0,000 0,11708439 0,14394739 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of biotic stimulus GO:0009595 29 21 0,000 0,11708439 0,14387387 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,11708439 0,14380043 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,11708439 0,14372706 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,11708439 0,14365377 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,11708439 0,14358055 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,11708439 0,14350741 ! collagen catabolic process GO:0030574 28 21 0,000 0,11708439 0,14343434 ! sperm-egg recognition GO:0035036 21 21 0,000 0,11708439 0,14336134 ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,12230631 0,14967904 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,12230631 0,14960294 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,12230631 0,14952692 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,12230631 0,14945098 GO:0034105|positive regulation of tissue remodeling, ! microtubule-based transport GO:0010970 54 22 0,000 0,12230631 0,14937512 ! regulation of chemotaxis GO:0050920 40 22 0,000 0,12230631 0,14929933 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,12230631 0,14922362 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,12230631 0,14914799 ! keratinization GO:0031424 28 22 0,000 0,12230631 0,14907244 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,12230631 0,14899696 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,12230631 0,14892155 ! sensory perception of taste GO:0050909 28 22 0,000 0,12230631 0,14884623 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 0,000 0,12230631 0,14877097 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,12230631 0,1486958 ! vacuolar transport GO:0007034 36 22 0,000 0,12230631 0,1486207 ! lysosome organization GO:0007040 41 22 0,000 0,12230631 0,14854568 ! central nervous system neuron development GO:0021954 46 22 0,000 0,12230631 0,14847073 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,12230631 0,14839586 ! fucose metabolic process GO:0006004 39 22 0,000 0,12230631 0,14832106 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,12230631 0,14824634 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,12230631 0,1481717 GO:0060415|muscle tissue morphogenesis, ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,12230631 0,14809713 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,12230631 0,14802263 ! sarcomere organization GO:0045214 30 22 0,000 0,12230631 0,14794821 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,12230631 0,14787386 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,12230631 0,14779959 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,12230631 0,1477254 ! protein stabilization GO:0050821 39 22 0,000 0,12230631 0,14765127 ! positive regulation of DNA replication GO:0045740 43 23 0,000 0,12749752 0,15384104 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,12749752 0,15376393 ! gluconeogenesis GO:0006094 33 23 0,000 0,12749752 0,15368689 ! viral genome replication GO:0019079 41 23 0,000 0,12749752 0,15360993 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,12749752 0,15353305 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,12749752 0,15345625 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,12749752 0,15337952 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,12749752 0,15330287 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,12749752 0,15322629 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,12749752 0,1531498 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,12749752 0,15307337 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,12749752 0,15299703 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,12749752 0,15292076 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,12749752 0,15284456 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,12749752 0,15276845 GO:0051693|actin filament capping, ! sex determination GO:0007530 47 23 0,000 0,12749752 0,1526924 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 0,000 0,12749752 0,15261644 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,12749752 0,15254055 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,12749752 0,15246473 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,12749752 0,15238899 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,12749752 0,15231333 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,12749752 0,15223774 ! fatty acid transport GO:0015908 44 23 0,000 0,12749752 0,15216222 ! platelet activation GO:0030168 37 23 0,000 0,12749752 0,15208678 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,12749752 0,15201142 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,12749752 0,15193613 ! hormone transport GO:0009914 40 23 0,000 0,12749752 0,15186091 ! cell-cell recognition GO:0009988 25 23 0,000 0,12749752 0,15178577 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,12749752 0,1517107 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,12749752 0,15163571 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,12749752 0,15156079 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,12749752 0,15148595 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,12749752 0,15141117 ! protein import into nucleus, translocation GO:0000060 46 24 0,000 0,1326582 0,15746208 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,1326582 0,15738443 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 52 24 0,000 0,1326582 0,15730687 ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,1326582 0,15722937 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,1326582 0,15715196 ! vesicle docking GO:0048278 47 24 0,000 0,1326582 0,15707462 ! vacuole organization GO:0007033 43 24 0,000 0,1326582 0,15699736 ! digestive system process GO:0022600 39 24 0,000 0,1326582 0,15692017 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,1326582 0,15684306 ! regulation of behavior GO:0050795 43 24 0,000 0,1326582 0,15676603 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,1326582 0,15668907 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,1326582 0,15661218 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,1326582 0,15653538 ! membrane depolarization GO:0051899 39 24 0,000 0,1326582 0,15645864 ! pentose metabolic process GO:0019321 35 24 0,000 0,1326582 0,15638198 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,1326582 0,1563054 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,1326582 0,15622889 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,1326582 0,15615246 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,1326582 0,1560761 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,1326582 0,15599982 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,1326582 0,15592361 ! regulation of amine transport GO:0051952 40 24 0,000 0,1326582 0,15584748 ! protein tetramerization GO:0051262 52 24 0,000 0,1326582 0,15577142 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,13778852 0,16171668 ! phototransduction GO:0007602 33 25 0,000 0,13778852 0,16163783 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,13778852 0,16155906 GO:0006479|protein amino acid methylation, ! vasculogenesis GO:0001570 46 25 0,000 0,13778852 0,16148037 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 0,000 0,13778852 0,16140175 ! sperm motility GO:0030317 31 25 0,000 0,13778852 0,16132321 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,13778852 0,16124474 ! negative regulation of DNA replication GO:0008156 42 25 0,000 0,13778852 0,16116635 ! receptor metabolic process GO:0043112 46 25 0,000 0,13778852 0,16108804 ! chromosome condensation GO:0030261 45 25 0,000 0,13778852 0,16100981 ! response to starvation GO:0042594 42 25 0,000 0,13778852 0,16093165 ! neural crest cell development GO:0014032 54 25 0,000 0,13778852 0,16085356 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,13778852 0,16077555 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,13778852 0,16069762 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,13778852 0,16061976 ! interaction with host GO:0051701 62 25 0,000 0,13778852 0,16054198 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,13778852 0,16046427 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,13778852 0,16038664 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! immunoglobulin production GO:0002377 55 25 0,000 0,13778852 0,16030909 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,13778852 0,1602316 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,13778852 0,1601542 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,13778852 0,16007687 ! cellular response to nutrient levels GO:0031669 41 25 0,000 0,13778852 0,15999961 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,13778852 0,15992243 ! telomere organization GO:0032200 43 25 0,000 0,13778852 0,15984532 GO:0000723|telomere maintenance, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,14288867 0,165682 ! embryonic pattern specification GO:0009880 44 26 0,000 0,14288867 0,16560219 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,14288867 0,16552246 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,14288867 0,1654428 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,14288867 0,16536323 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,14288867 0,16528372 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,14288867 0,1652043 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,14288867 0,16512495 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,14288867 0,16504568 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,14288867 0,16496648 ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,14288867 0,16488736 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,14288867 0,16480832 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,14288867 0,16472935 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,14288867 0,16465045 ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,14288867 0,16457164 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,14288867 0,16449289 ! blastocyst development GO:0001824 49 26 0,000 0,14288867 0,16441423 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,14288867 0,16433563 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,14288867 0,16425712 ! neuron fate commitment GO:0048663 48 27 0,000 0,14795882 0,17000426 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 0,000 0,14795882 0,16992311 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,14795882 0,16984204 ! iron ion transport GO:0006826 59 27 0,000 0,14795882 0,16976105 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,14795882 0,16968013 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,14795882 0,1695993 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,14795882 0,16951853 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,14795882 0,16943785 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,14795882 0,16935724 ! autophagy GO:0006914 41 27 0,000 0,14795882 0,16927671 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,14795882 0,16919626 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,14795882 0,16911588 ! glutathione metabolic process GO:0006749 39 27 0,000 0,14795882 0,16903558 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,14795882 0,16895535 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,14795882 0,1688752 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,14795882 0,16879513 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,15299914 0,17446253 ! circadian rhythm GO:0007623 50 28 0,000 0,15299914 0,17437989 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,15299914 0,17429732 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! negative regulation of protein modification process GO:0031400 60 28 0,000 0,15299914 0,17421483 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,15299914 0,17413242 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,15299914 0,17405009 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,15299914 0,17396784 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,15299914 0,17388566 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,15299914 0,17380356 ! synaptogenesis GO:0007416 42 28 0,000 0,15299914 0,17372154 ! lipid oxidation GO:0034440 43 28 0,000 0,15299914 0,17363959 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,15299914 0,17355773 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,15299914 0,17347594 ! translational initiation GO:0006413 65 29 0,000 0,15800982 0,17907283 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,15800982 0,17898852 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,15800982 0,17890429 ! regulation of pH GO:0006885 43 29 0,000 0,15800982 0,17882014 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,15800982 0,17873607 ! catechol metabolic process GO:0009712 54 29 0,000 0,15800982 0,17865208 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,15800982 0,17856816 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,15800982 0,17848433 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,15800982 0,17840057 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,15800982 0,17831689 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,15800982 0,1782333 ! cell fate determination GO:0001709 60 29 0,000 0,15800982 0,17814977 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,15800982 0,17806633 ! detection of light stimulus GO:0009583 38 29 0,000 0,15800982 0,17798297 ! regulation of coagulation GO:0050818 46 29 0,000 0,15800982 0,17789968 ! phenol metabolic process GO:0018958 55 30 0,000 0,16299101 0,18342207 ! zinc ion transport GO:0006829 45 30 0,000 0,16299101 0,18333632 ! membrane docking GO:0022406 61 30 0,000 0,16299101 0,18325064 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,16299101 0,18316505 ! regulation of innate immune response GO:0045088 51 30 0,000 0,16299101 0,18307954 ! acute-phase response GO:0006953 49 30 0,000 0,16299101 0,18299411 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,16299101 0,18290876 ! phospholipid transport GO:0015914 51 30 0,000 0,16299101 0,18282349 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,16299101 0,18273829 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,16299101 0,18265318 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,16299101 0,18256815 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,16794291 0,18802728 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,16794291 0,18793983 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,16794291 0,18785246 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,16794291 0,18776516 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,16794291 0,18767795 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,16794291 0,18759082 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,16794291 0,18750377 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,16794291 0,18741681 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,16794291 0,18732992 ! peptide transport GO:0015833 55 31 0,000 0,16794291 0,18724311 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,16794291 0,18715638 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,16794291 0,18706974 ! mesoderm formation GO:0001707 69 31 0,000 0,16794291 0,18698317 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,16794291 0,18689669 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,16794291 0,18681028 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,16794291 0,18672395 ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,16794291 0,18663771 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,17286567 0,19201976 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,17286567 0,19193115 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,17286567 0,19184262 ! cholesterol transport GO:0030301 56 32 0,000 0,17286567 0,19175417 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,17286567 0,1916658 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,17286567 0,19157752 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,17286567 0,19148932 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,17286567 0,19140119 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,17286567 0,19131315 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,17286567 0,19122519 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,17286567 0,19113731 ! BMP signaling pathway GO:0030509 64 32 0,000 0,17286567 0,19104952 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,17286567 0,1909618 ! positive regulation of catabolic process GO:0009896 64 32 0,000 0,17286567 0,19087416 ! gene silencing GO:0016458 65 32 0,000 0,17286567 0,1907866 ! positive regulation of gene-specific transcription GO:0043193 65 33 0,000 0,17775946 0,19609779 ! protein targeting to membrane GO:0006612 68 33 0,000 0,17775946 0,19600792 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,17775946 0,19591813 ! ceramide metabolic process GO:0006672 64 33 0,000 0,17775946 0,19582842 ! formation of primary germ layer GO:0001704 72 33 0,000 0,17775946 0,1957388 ! cell fate specification GO:0001708 52 33 0,000 0,17775946 0,19564926 ! sterol transport GO:0015918 57 33 0,000 0,17775946 0,1955598 ! leukocyte chemotaxis GO:0030595 50 33 0,000 0,17775946 0,19547042 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,17775946 0,19538112 ! adult locomotory behavior GO:0008344 59 33 0,000 0,17775946 0,19529191 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,18262447 0,20054517 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,18262447 0,20045368 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,18262447 0,20036228 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,18262447 0,20027095 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,18262447 0,20017972 ! mismatch repair GO:0006298 46 34 0,000 0,18262447 0,20008856 ! spermatid development GO:0007286 63 34 0,000 0,18262447 0,19999749 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,18262447 0,19990649 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,18262447 0,19981559 ! placenta development GO:0001890 53 34 0,000 0,18262447 0,19972476 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 0,000 0,18262447 0,19963402 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 0,000 0,18746085 0,2048278 ! negative regulation of secretion GO:0051048 63 35 0,000 0,18746085 0,20473482 ! negative regulation of DNA metabolic process GO:0051053 61 35 0,000 0,18746085 0,20464193 ! odontogenesis GO:0042476 66 35 0,000 0,18746085 0,20454912 ! embryonic skeletal system morphogenesis GO:0048704 59 35 0,000 0,18746085 0,20445639 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,18746085 0,20436375 GO:0006639|acylglycerol metabolic process, ! negative regulation of hydrolase activity GO:0051346 62 35 0,000 0,18746085 0,2042712 ! cytokine production GO:0001816 59 35 0,000 0,18746085 0,20417873 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,19226877 0,20932067 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,19226877 0,20922599 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,19226877 0,20913141 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,19226877 0,20903691 ! regulation of proteolysis GO:0030162 72 36 0,000 0,19226877 0,20894249 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,19226877 0,20884816 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,19226877 0,20875391 ! aerobic respiration GO:0009060 55 36 0,000 0,19226877 0,20865975 ! embryonic organ development GO:0048568 57 36 0,000 0,19226877 0,20856568 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,19226877 0,20847169 ! RNA export from nucleus GO:0006405 56 37 0,000 0,19704841 0,21355787 ! organic anion transport GO:0015711 68 37 0,000 0,19704841 0,21346172 ! tissue remodeling GO:0048771 76 37 0,000 0,19704841 0,21336565 ! monovalent inorganic cation homeostasis GO:0055067 58 37 0,000 0,19704841 0,21326967 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,19704841 0,21317377 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,19704841 0,21307796 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,19704841 0,21298224 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 66 37 0,000 0,19704841 0,21288661 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,20179992 0,21792217 GO:0006956|complement activation, ! positive regulation of DNA metabolic process GO:0051054 72 38 0,000 0,20179992 0,21782441 ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,20179992 0,21772673 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,20179992 0,21762914 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,20179992 0,21753163 ! carbohydrate homeostasis GO:0033500 53 38 0,000 0,20179992 0,21743421 GO:0042593|glucose homeostasis, ! lipid homeostasis GO:0055088 67 38 0,000 0,20179992 0,21733688 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,20179992 0,21723964 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,20179992 0,21714249 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,20179992 0,21704542 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,20179992 0,21694844 ! organic ether metabolic process GO:0018904 55 39 0,000 0,20652347 0,2219274 ! ion transmembrane transport GO:0034220 66 39 0,000 0,20652347 0,22182833 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,20652347 0,22172934 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,20652347 0,22163045 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,20652347 0,22153164 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,21121922 0,22646766 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,21121922 0,22636679 ! feeding behavior GO:0007631 59 40 0,000 0,21121922 0,226266 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,21121922 0,2261653 ! maintenance of protein location GO:0045185 91 40 0,000 0,21121922 0,2260647 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,21588734 0,23095817 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,21588734 0,23085552 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,21588734 0,23075297 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,21588734 0,2306505 ! polyol metabolic process GO:0019751 66 41 0,000 0,21588734 0,23054813 ! dorsal/ventral pattern formation GO:0009953 68 41 0,000 0,21588734 0,23044584 ! regulation of tube size GO:0035150 71 42 0,000 0,22052798 0,23529504 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,22052798 0,23519075 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,22052798 0,23508654 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,22052798 0,23498243 ! regulation of protein secretion GO:0050708 71 42 0,000 0,22052798 0,23487841 ! epithelial cell differentiation GO:0030855 79 43 0,000 0,22514131 0,23968584 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,22514131 0,23957983 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,22514131 0,23947392 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,22514131 0,2393681 ! phagocytosis GO:0006909 90 43 0,000 0,22514131 0,23926237 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,22514131 0,23915673 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,2297275 0,24392072 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,2297275 0,24381313 ! double-strand break repair GO:0006302 81 44 0,000 0,2297275 0,24370563 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,2297275 0,24359822 ! maintenance of location in cell GO:0051651 97 44 0,000 0,2297275 0,24349091 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,23428669 0,2482139 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,23428669 0,24810465 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,23428669 0,2479955 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,23428669 0,24788644 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,23428669 0,24777748 ! regulation of gene-specific transcription GO:0032583 96 46 0,000 0,23881904 0,25245985 ! endosome transport GO:0016197 108 47 0,000 0,24332472 0,25710991 ! vascular process in circulatory system GO:0003018 80 47 0,000 0,24332472 0,25699705 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,24332472 0,25688428 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,24332472 0,25677161 ! Notch signaling pathway GO:0007219 96 48 0,000 0,24780387 0,26138366 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,24780387 0,26126911 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,24780387 0,26115467 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,25225666 0,26573097 ! regulation of ion transport GO:0043269 77 49 0,000 0,25225666 0,26561467 ! peptide metabolic process GO:0006518 76 49 0,000 0,25225666 0,26549848 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,25225666 0,26538239 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,25225666 0,2652664 GO:0019724|B cell mediated immunity, ! regulation of cell projection organization GO:0031344 121 50 0,000 0,25668324 0,26980335 ! neuromuscular process GO:0050905 99 50 0,000 0,25668324 0,26968553 ! inner ear development GO:0048839 79 50 0,000 0,25668324 0,26956782 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,25668324 0,26945021 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,26108376 0,27395007 ! embryonic skeletal system development GO:0048706 85 51 0,000 0,26108376 0,27383065 ! excretion GO:0007588 83 51 0,000 0,26108376 0,27371134 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,26108376 0,27359213 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,26108376 0,27347302 ! regulation of muscle contraction GO:0006937 81 52 0,000 0,26545837 0,27793422 ! amino acid activation GO:0043038 92 52 0,000 0,26545837 0,27781333 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! cartilage development GO:0051216 90 52 0,000 0,26545837 0,27769254 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,26980723 0,28211916 ! regulation of translational initiation GO:0006446 82 53 0,000 0,26980723 0,28199661 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,26980723 0,28187416 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,26980723 0,28175182 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,26980723 0,28162958 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,26980723 0,28150745 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,27413048 0,28589421 ! cell recognition GO:0008037 85 54 0,000 0,27413048 0,28577034 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,27413048 0,28564657 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,27413048 0,28552292 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,27413048 0,28539937 ! chloride transport GO:0006821 90 55 0,000 0,27842828 0,28974846 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,27842828 0,28962319 ! regulation of protein catabolic process GO:0042176 116 55 0,000 0,27842828 0,28949803 ! gastrulation GO:0007369 112 55 0,000 0,27842828 0,28937298 ! heart morphogenesis GO:0003007 97 55 0,000 0,27842828 0,28924803 ! RNA elongation GO:0006354 79 55 0,000 0,27842828 0,2891232 ! nuclear export GO:0051168 97 55 0,000 0,27842828 0,28899847 ! regulation of actin filament length GO:0030832 105 56 0,000 0,28270078 0,29330663 ! sensory perception of smell GO:0007608 80 56 0,000 0,28270078 0,2931802 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,28270078 0,29305389 ! nucleotide-excision repair GO:0006289 83 56 0,000 0,28270078 0,29292768 ! proton transport GO:0015992 94 56 0,000 0,28270078 0,29280158 ! maintenance of location GO:0051235 118 57 0,000 0,28694812 0,29707279 ! hydrogen transport GO:0006818 97 58 0,000 0,29117045 0,30131445 ! regulation of endocytosis GO:0030100 91 58 0,000 0,29117045 0,30118491 ! adult behavior GO:0030534 99 58 0,000 0,29117045 0,30105548 ! positive regulation of secretion GO:0051047 95 59 0,000 0,29536791 0,30526426 ! regulation of cellular component size GO:0032535 109 59 0,000 0,29536791 0,30513319 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,29536791 0,30500223 GO:0032313|regulation of Rab GTPase activity, ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,29954066 0,30917839 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,29954066 0,30904581 ! regulation of heart contraction GO:0008016 110 60 0,000 0,29954066 0,30891335 ! negative regulation of response to stimulus GO:0048585 100 60 0,000 0,29954066 0,30878099 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,30368884 0,31292306 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,30368884 0,31278911 ! mesoderm development GO:0007498 119 61 0,000 0,30368884 0,31265526 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,30368884 0,31252154 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,30781259 0,31662979 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,31191205 0,32070957 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,31191205 0,32057257 ! cell redox homeostasis GO:0045454 102 64 0,000 0,31598737 0,32462238 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,31598737 0,32448383 ! single fertilization GO:0007338 75 64 0,000 0,31598737 0,3243454 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,32003869 0,32836379 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,32406615 0,33235428 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,32406615 0,33221267 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,32806988 0,33617382 ! adaptive immune response GO:0002250 119 67 0,000 0,32806988 0,33603071 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 105 67 0,000 0,32806988 0,33588772 ! amino acid transport GO:0006865 125 68 0,000 0,33205003 0,33981811 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,33205003 0,33967363 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,33205003 0,33952927 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,33600674 0,34342915 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,33600674 0,34328332 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,33600674 0,34313761 ! antigen processing and presentation GO:0019882 104 69 0,000 0,33600674 0,34299203 ! amine catabolic process GO:0009310 117 71 0,000 0,34385037 0,35084987 ! regulation of immune effector process GO:0002697 137 71 0,000 0,34385037 0,35070114 ! acute inflammatory response GO:0002526 113 72 0,000 0,34773756 0,3545155 ! regulation of blood pressure GO:0008217 125 73 0,000 0,35160186 0,35830329 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,35160186 0,35815159 ! fertilization GO:0009566 90 73 0,000 0,35160186 0,35800003 ! transition metal ion transport GO:0000041 126 74 0,000 0,35544338 0,36175837 ! neurotransmitter transport GO:0006836 123 74 0,000 0,35544338 0,3616054 ! exocytosis GO:0006887 133 74 0,000 0,35544338 0,36145257 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,35544338 0,36129987 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,35544338 0,36114729 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,35926228 0,36487338 ! defense response to bacterium GO:0042742 89 76 0,000 0,36305868 0,36857349 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,36305868 0,36841804 ! regulation of catabolic process GO:0009894 161 76 0,000 0,36305868 0,36826272 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,3668327 0,37193404 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,3668327 0,37177737 ! blood coagulation GO:0007596 146 78 0,000 0,37058449 0,3754216 GO:0050817|coagulation, ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,37058449 0,37526359 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,37431418 0,3788809 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,37431418 0,37872158 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,37802188 0,38231217 ! inorganic anion transport GO:0015698 138 80 0,000 0,37802188 0,38215153 ! digestion GO:0007586 112 81 0,000 0,38170774 0,38571559 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,38170774 0,38555366 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,38537188 0,38909137 ! hemostasis GO:0007599 158 84 0,000 0,3926355 0,39625881 ! amine biosynthetic process GO:0009309 138 86 0,000 0,39981376 0,40333413 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,39981376 0,40316509 ! amine transport GO:0015837 155 86 0,000 0,39981376 0,40299619 ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,40337118 0,40641167 ! cellular respiration GO:0045333 135 88 0,000 0,40690765 0,40980318 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,40690765 0,40963171 ! cellular defense response GO:0006968 114 89 0,000 0,41042326 0,41299806 ! sterol metabolic process GO:0016125 152 91 0,000 0,41739245 0,41983538 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,41739245 0,41965994 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,42084626 0,42295576 ! vitamin metabolic process GO:0006766 139 92 0,000 0,42084626 0,42277916 ! carbohydrate biosynthetic process GO:0016051 141 93 0,000 0,42427971 0,42605049 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,42769292 0,42929878 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,43445909 0,43590849 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,43445909 0,43572679 ! positive regulation of immune response GO:0050778 156 96 0,000 0,43445909 0,43554524 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,43781228 0,43872401 ! protein ubiquitination GO:0016567 217 97 0,000 0,43781228 0,43854136 ! hormone metabolic process GO:0042445 157 97 0,000 0,43781228 0,43835887 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,44114571 0,44151272 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,44114571 0,44132914 GO:0016054|organic acid catabolic process, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,44445948 0,44445948