pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6408-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! nuclear migration GO:0007097 13 6 2,000 2,443E-07 5,969E-04 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 2,443E-07 2,984E-04 GO:0031272|regulation of pseudopodium assembly, ! protein amino acid autophosphorylation GO:0046777 157 64 4,000 4,205E-07 3,424E-04 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 6,818E-07 4,164E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 6,818E-07 3,331E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 6,818E-07 2,776E-04 ! macrophage differentiation GO:0030225 15 9 2,000 1,021E-06 3,563E-04 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 2,000 1,999E-06 6,103E-04 ! nucleus localization GO:0051647 22 11 2,000 1,999E-06 5,425E-04 ! regulation of cell projection assembly GO:0060491 33 12 2,000 2,66E-06 6,499E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 3,000 4,185E-06 9,295E-04 ! epithelial to mesenchymal transition GO:0001837 30 15 2,000 5,474E-06 1,114E-03 ! filopodium assembly GO:0046847 42 17 2,000 8,154E-06 1,532E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 9,768E-06 1,705E-03 ! microspike assembly GO:0030035 46 18 2,000 9,768E-06 1,591E-03 ! viral reproductive process GO:0022415 132 62 3,000 1,391E-05 2,123E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 1,584E-05 2,276E-03 ! regulation of lipid metabolic process GO:0019216 132 66 3,000 1,784E-05 2,421E-03 ! viral reproduction GO:0016032 142 68 3,000 2,009E-05 2,583E-03 ! negative regulation of protein kinase activity GO:0006469 144 69 3,000 2,129E-05 2,6E-03 ! negative regulation of kinase activity GO:0033673 145 70 3,000 2,254E-05 2,622E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 3,000 2,384E-05 2,647E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 2,398E-05 2,548E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 2,721E-05 2,77E-03 ! interaction with host GO:0051701 66 25 2,000 2,721E-05 2,659E-03 ! negative regulation of transferase activity GO:0051348 155 74 3,000 2,808E-05 2,638E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 3,449E-05 3,12E-03 ! insulin receptor signaling pathway GO:0008286 66 27 2,000 3,449E-05 3,009E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 4,763E-05 4,012E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 5,363E-05 4,367E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 5,363E-05 4,226E-03 ! muscle cell proliferation GO:0033002 12 5 1,000 5,363E-05 4,094E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 5,363E-05 3,97E-03 ! positive regulation of catabolic process GO:0009896 72 32 2,000 5,799E-05 4,167E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 3,000 6,889E-05 4,809E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 6,973E-05 4,732E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 1,000 8,032E-05 5,303E-03 ! activation of MAPKKK activity GO:0000185 12 6 1,000 8,032E-05 5,164E-03 ! negative regulation of gliogenesis GO:0014014 18 6 1,000 8,032E-05 5,031E-03 GO:0045686|negative regulation of glial cell differentiation, ! progesterone metabolic process GO:0042448 12 6 1,000 8,032E-05 4,906E-03 ! interphase of mitotic cell cycle GO:0051329 224 98 3,000 8,448E-05 5,034E-03 ! androgen receptor signaling pathway GO:0030521 81 37 2,000 9,008E-05 5,24E-03 ! cellular response to insulin stimulus GO:0032869 85 38 2,000 9,764E-05 5,547E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,123E-04 6,234E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,123E-04 6,095E-03 ! male sex determination GO:0030238 15 7 1,000 1,123E-04 5,963E-03 ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 1,228E-04 6,381E-03 ! mesenchymal cell development GO:0014031 94 41 2,000 1,228E-04 6,248E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of intracellular protein transport GO:0033157 86 42 2,000 1,32E-04 6,58E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,495E-04 7,303E-03 ! cerebral cortex neuron differentiation GO:0021895 16 8 1,000 1,495E-04 7,16E-03 ! cardiac muscle cell differentiation GO:0055007 31 8 1,000 1,495E-04 7,022E-03 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 1,000 1,495E-04 6,89E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 1,495E-04 6,762E-03 ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 1,623E-04 7,209E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 2,000 1,733E-04 7,562E-03 ! response to insulin stimulus GO:0032868 98 47 2,000 1,848E-04 7,922E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,919E-04 8,083E-03 ! regulation of glycolysis GO:0006110 20 9 1,000 1,919E-04 7,946E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 1,919E-04 7,813E-03 ! retinoic acid receptor signaling pathway GO:0048384 16 9 1,000 1,919E-04 7,685E-03 ! regulation of mast cell proliferation GO:0070666 89 49 2,000 2,093E-04 8,248E-03 ! regulation of cell projection organization GO:0031344 135 51 2,000 2,358E-04 9,144E-03 ! viral infectious cycle GO:0019058 104 51 2,000 2,358E-04 9,001E-03 ! regulation of developmental growth GO:0048638 16 10 1,000 2,395E-04 9,001E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 2,395E-04 8,865E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 2,395E-04 8,733E-03 ! motor axon guidance GO:0008045 22 10 1,000 2,395E-04 8,604E-03 ! protein heterooligomerization GO:0051291 17 10 1,000 2,395E-04 8,48E-03 ! regulation of gliogenesis GO:0014013 23 10 1,000 2,395E-04 8,359E-03 GO:0045685|regulation of glial cell differentiation, ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 2,395E-04 8,241E-03 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of leukocyte proliferation GO:0070663 97 53 2,000 2,644E-04 8,97E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,923E-04 9,781E-03 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,923E-04 9,649E-03 ! neuroblast proliferation GO:0007405 25 11 1,000 2,923E-04 9,52E-03 ! cardiac cell differentiation GO:0035051 36 11 1,000 2,923E-04 9,395E-03 ! regulation of embryonic development GO:0045995 35 11 1,000 2,923E-04 9,273E-03 ! response to UV GO:0009411 120 55 2,000 2,951E-04 9,242E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 2,000 3,28E-04 0,01014277 ! heart morphogenesis GO:0003007 105 57 2,000 3,28E-04 0,01001598 ! regulation of intracellular transport GO:0032386 108 57 2,000 3,28E-04 9,892E-03 ! positive regulation of cell migration GO:0030335 137 58 2,000 3,453E-04 0,01028738 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 3,502E-04 0,01030772 ! virus-host interaction GO:0019048 30 12 1,000 3,502E-04 0,01018501 ! regulation of B cell proliferation GO:0030888 22 12 1,000 3,502E-04 0,01006518 ! hippocampus development GO:0021766 29 12 1,000 3,502E-04 9,948E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 3,502E-04 9,834E-03 ! entry into host cell GO:0030260 34 12 1,000 3,502E-04 9,722E-03 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! histone acetylation GO:0016573 27 12 1,000 3,502E-04 9,613E-03 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,502E-04 9,506E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 1,000 3,502E-04 9,402E-03 GO:0042130|negative regulation of T cell proliferation, ! localization within membrane GO:0051668 26 12 1,000 3,502E-04 9,299E-03 ! establishment of organelle localization GO:0051656 122 59 2,000 3,632E-04 9,54E-03 ! double-strand break repair via homologous recombination GO:0000724 19 13 1,000 4,132E-04 0,01074 GO:0000725|recombinational repair, ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 4,132E-04 0,01062695 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 4,132E-04 0,01051625 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 4,132E-04 0,01040783 ! regulation of fatty acid oxidation GO:0046320 34 13 1,000 4,132E-04 0,01030163 ! regulation of protein complex assembly GO:0043254 132 63 2,000 4,407E-04 0,01087439 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 4,616E-04 0,01127614 ! bone mineralization GO:0030282 18 14 1,000 4,814E-04 0,0116439 ! positive regulation of cell motion GO:0051272 157 65 2,000 4,831E-04 0,01157051 ! steroid hormone receptor signaling pathway GO:0030518 146 66 2,000 5,052E-04 0,01198365 ! myeloid cell differentiation GO:0030099 126 67 2,000 5,28E-04 0,0124039 ! cell projection assembly GO:0030031 138 68 2,000 5,515E-04 0,01283123 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 5,546E-04 0,01278212 ! regulation of mRNA processing GO:0050684 26 15 1,000 5,546E-04 0,01266266 ! cAMP biosynthetic process GO:0006171 25 15 1,000 5,546E-04 0,01254541 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 6,329E-04 0,01418454 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 6,329E-04 0,01405559 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 6,329E-04 0,01392896 ! biomineral formation GO:0031214 22 16 1,000 6,329E-04 0,0138046 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 1,000 6,329E-04 0,01368243 ! negative regulation of leukocyte proliferation GO:0070664 32 16 1,000 6,329E-04 0,01356241 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! organelle localization GO:0051640 155 74 2,000 7,062E-04 0,01500182 ! activation of MAPKK activity GO:0000186 43 17 1,000 7,162E-04 0,01508282 ! regulation of catabolic process GO:0009894 173 77 2,000 7,929E-04 0,0165557 ! limbic system development GO:0021761 40 18 1,000 8,045E-04 0,0166553 ! response to retinoic acid GO:0032526 31 18 1,000 8,045E-04 0,01651534 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 1,000 8,045E-04 0,01637771 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 8,045E-04 0,01624236 ! steroid biosynthetic process GO:0006694 146 79 2,000 8,543E-04 0,01710657 ! protein oligomerization GO:0051259 149 79 2,000 8,543E-04 0,0169675 ! protein amino acid ADP-ribosylation GO:0006471 37 19 1,000 8,978E-04 0,01768719 ! response to vitamin A GO:0033189 32 19 1,000 8,978E-04 0,0175457 ! neuromuscular junction development GO:0007528 43 19 1,000 8,978E-04 0,01740644 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 9,96E-04 0,01915914 ! protein amino acid acetylation GO:0006473 41 20 1,000 9,96E-04 0,01900946 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 1,000 9,96E-04 0,0188621 ! response to vitamin GO:0033273 36 20 1,000 9,96E-04 0,018717 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 9,96E-04 0,01857413 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of fatty acid metabolic process GO:0019217 45 20 1,000 9,96E-04 0,01843341 ! negative regulation of T cell activation GO:0050868 41 20 1,000 9,96E-04 0,01829482 ! cholesterol metabolic process GO:0008203 148 85 2,000 1,056E-03 0,019258 ! cellular response to hormone stimulus GO:0032870 182 85 2,000 1,056E-03 0,01911535 ! lipid phosphorylation GO:0046834 43 21 1,000 1,099E-03 0,01974459 ! cAMP metabolic process GO:0046058 41 21 1,000 1,099E-03 0,01960047 ! C21-steroid hormone metabolic process GO:0008207 38 21 1,000 1,099E-03 0,01945844 ! regulation of vasoconstriction GO:0019229 40 21 1,000 1,099E-03 0,01931845 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 1,099E-03 0,01918046 ! regulation of protein transport GO:0051223 165 87 2,000 1,13E-03 0,01957495 GO:0070201|regulation of establishment of protein localization, ! positive regulation of protein catabolic process GO:0045732 44 22 1,000 1,207E-03 0,02076984 ! cholesterol biosynthetic process GO:0006695 39 22 1,000 1,207E-03 0,0206246 ! positive regulation of intracellular transport GO:0032388 42 22 1,000 1,207E-03 0,02048137 ! positive regulation of B cell activation GO:0050871 42 22 1,000 1,207E-03 0,02034012 ! ossification GO:0001503 205 91 2,000 1,286E-03 0,02152248 ! positive regulation of DNA replication GO:0045740 44 23 1,000 1,32E-03 0,02194091 ! viral genome replication GO:0019079 44 23 1,000 1,32E-03 0,02179266 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 1,000 1,32E-03 0,0216464 GO:0060415|muscle tissue morphogenesis, ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 1,32E-03 0,02150209 ! bone development GO:0060348 206 92 2,000 1,327E-03 0,02147525 ! sterol metabolic process GO:0016125 166 94 2,000 1,412E-03 0,02269568 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 1,438E-03 0,02296208 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 1,438E-03 0,02281297 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 1,438E-03 0,02266579 ! sex determination GO:0007530 48 24 1,000 1,438E-03 0,0225205 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 1,438E-03 0,02237705 ! pallium development GO:0021543 56 24 1,000 1,438E-03 0,02223543 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 1,438E-03 0,02209558 ! regulation of protein localization GO:0032880 188 97 2,000 1,545E-03 0,02359675 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 1,561E-03 0,02368269 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 1,000 1,561E-03 0,0235365 ! phototransduction GO:0007602 37 25 1,000 1,561E-03 0,0233921 ! protein tetramerization GO:0051262 57 25 1,000 1,561E-03 0,02324947 ! leukocyte differentiation GO:0002521 232 98 2,000 1,592E-03 0,02356477 ! forebrain development GO:0030900 210 98 2,000 1,592E-03 0,02342282 ! skeletal muscle tissue development GO:0007519 223 100 2,000 1,686E-03 0,02466996 GO:0060538|skeletal muscle organ development, ! myelination GO:0042552 50 26 1,000 1,688E-03 0,02455003 ! initiation of viral infection GO:0019059 60 26 1,000 1,688E-03 0,02440476 ! protein amino acid alkylation GO:0008213 59 26 1,000 1,688E-03 0,0242612 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 1,000 1,688E-03 0,02411932 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 1,688E-03 0,02397909 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 1,688E-03 0,02384049 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 51 26 1,000 1,688E-03 0,02370347 ! negative regulation of cell development GO:0010721 83 26 1,000 1,688E-03 0,02356802 GO:0050768|negative regulation of neurogenesis, ! negative regulation of lymphocyte activation GO:0051250 55 27 1,000 1,821E-03 0,02527055 ! regulation of fibroblast proliferation GO:0048145 56 28 1,000 1,958E-03 0,02701974 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 1,000 1,958E-03 0,02686795 ! protein amino acid acylation GO:0043543 59 28 1,000 1,958E-03 0,02671785 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 1,000 1,958E-03 0,02656941 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 1,958E-03 0,02642262 ! somitogenesis GO:0001756 52 29 1,000 2,099E-03 0,02818123 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 2,099E-03 0,02802723 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 1,000 2,246E-03 0,02982081 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sterol biosynthetic process GO:0016126 56 30 1,000 2,246E-03 0,02965961 ! tissue homeostasis GO:0001894 50 30 1,000 2,246E-03 0,02950015 GO:0048871|multicellular organismal homeostasis, ! regulation of B cell activation GO:0050864 55 30 1,000 2,246E-03 0,0293424 ! detection of light stimulus GO:0009583 44 31 1,000 2,397E-03 0,031152 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 2,397E-03 0,03098717 ! ensheathment of neurons GO:0007272 64 31 1,000 2,397E-03 0,03082408 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 60 31 1,000 2,397E-03 0,0306627 ! response to heat GO:0009408 54 31 1,000 2,397E-03 0,030503 ! regulation of protein import into nucleus GO:0042306 69 32 1,000 2,553E-03 0,03231901 ! peripheral nervous system development GO:0007422 68 32 1,000 2,553E-03 0,03215242 ! negative regulation of protein transport GO:0051224 74 33 1,000 2,714E-03 0,03399978 ! telencephalon development GO:0021537 81 35 1,000 3,049E-03 0,03800354 ! calcium-mediated signaling GO:0019722 67 35 1,000 3,049E-03 0,03781063 ! hormone biosynthetic process GO:0042446 62 37 1,000 3,403E-03 0,04198161 ! negative regulation of cell activation GO:0050866 69 37 1,000 3,403E-03 0,04177064 ! positive regulation of DNA metabolic process GO:0051054 77 38 1,000 3,586E-03 0,04380452 ! cyclic nucleotide metabolic process GO:0009187 69 38 1,000 3,586E-03 0,04358659 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 3,586E-03 0,04337081 ! carbohydrate homeostasis GO:0033500 59 39 1,000 3,774E-03 0,0454213 GO:0042593|glucose homeostasis, ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 3,774E-03 0,04519864 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mammary gland development GO:0030879 93 40 1,000 3,967E-03 0,04727395 ! learning GO:0007612 82 40 1,000 3,967E-03 0,04704447 ! regulation of action potential in neuron GO:0019228 80 40 1,000 3,967E-03 0,0468172 ! regulation of T cell differentiation GO:0045580 78 42 1,000 4,366E-03 0,05127539 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 4,572E-03 0,05343857 GO:0090047|positive regulation of transcription regulator activity, ! striated muscle cell differentiation GO:0051146 91 43 1,000 4,572E-03 0,0531841 ! regulation of T cell proliferation GO:0042129 80 43 1,000 4,572E-03 0,05293204 ! segmentation GO:0035282 78 43 1,000 4,572E-03 0,05268236 ! double-strand break repair GO:0006302 85 44 1,000 4,782E-03 0,05484906 ! induction of apoptosis by intracellular signals GO:0008629 95 45 1,000 4,997E-03 0,05704577 ! biopolymer methylation GO:0043414 91 45 1,000 4,997E-03 0,05678044 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 5,216E-03 0,05899744 ! positive regulation of protein transport GO:0051222 80 46 1,000 5,216E-03 0,05872556 ! positive regulation of cell cycle GO:0045787 96 48 1,000 5,668E-03 0,06351679 ! positive regulation of DNA binding GO:0043388 83 48 1,000 5,668E-03 0,06322676 ! methylation GO:0032259 97 48 1,000 5,668E-03 0,06293936 ! detection of stimulus involved in sensory perception GO:0050906 75 49 1,000 5,9E-03 0,06522226 ! regulation of lymphocyte differentiation GO:0045619 92 49 1,000 5,9E-03 0,06492846 ! protein homooligomerization GO:0051260 84 49 1,000 5,9E-03 0,0646373 ! regulation of action potential GO:0001508 102 50 1,000 6,137E-03 0,06692892 ! response to temperature stimulus GO:0009266 84 51 1,000 6,378E-03 0,0692466 ! detection of abiotic stimulus GO:0009582 80 51 1,000 6,378E-03 0,0689402 ! negative regulation of immune system process GO:0002683 101 51 1,000 6,378E-03 0,0686365 ! positive regulation of binding GO:0051099 88 52 1,000 6,623E-03 0,07096181 ! histone modification GO:0016570 104 52 1,000 6,623E-03 0,07065193 ! amino acid activation GO:0043038 98 52 1,000 6,623E-03 0,07034475 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! positive regulation of growth GO:0045927 96 53 1,000 6,872E-03 0,07267726 ! chromatin remodeling GO:0006338 122 53 1,000 6,872E-03 0,072364 ! synapse organization GO:0050808 102 53 1,000 6,872E-03 0,07205342 ! regulation of angiogenesis GO:0045765 125 54 1,000 7,126E-03 0,07439274 ! regulation of translational initiation GO:0006446 87 54 1,000 7,126E-03 0,07407617 ! activation of phospholipase C activity GO:0007202 110 54 1,000 7,126E-03 0,07376229 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 7,126E-03 0,07345106 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 7,383E-03 0,07578823 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 1,000 7,383E-03 0,07547113 ! skeletal muscle fiber development GO:0048741 130 56 1,000 7,645E-03 0,0778229 ! regulation of protein catabolic process GO:0042176 126 56 1,000 7,645E-03 0,07749999 ! regulation of DNA replication GO:0006275 105 56 1,000 7,645E-03 0,07717974 ! muscle fiber development GO:0048747 131 57 1,000 7,911E-03 0,07953721 ! regulation of phospholipase activity GO:0010517 113 57 1,000 7,911E-03 0,07921123 ! positive regulation of lipase activity GO:0060193 115 58 1,000 8,182E-03 0,08158238 ! lipid modification GO:0030258 112 60 1,000 8,734E-03 0,08674009 ! tRNA processing GO:0008033 102 62 1,000 9,303E-03 0,09201717 ! nucleoside monophosphate metabolic process GO:0009123 117 65 1,000 0,01018718 0,10035191 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,01079625 0,10592466 ! activation of MAPK activity GO:0000187 124 67 1,000 0,01079625 0,10550097 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,01079625 0,10508064 GO:0035113|embryonic appendage morphogenesis, ! fatty acid biosynthetic process GO:0006633 139 67 1,000 0,01079625 0,10466366 ! detection of external stimulus GO:0009581 102 68 1,000 0,0111067 0,10724769 ! regulation of lipase activity GO:0060191 137 68 1,000 0,0111067 0,10682545 ! negative regulation of cell size GO:0045792 144 69 1,000 0,01142106 0,10941823 ! cellular hormone metabolic process GO:0034754 120 69 1,000 0,01142106 0,10899082 ! lung development GO:0030324 165 69 1,000 0,01142106 0,10856673 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 1,000 0,01142106 0,10814593 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01162192 0,10962297 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01162192 0,10920134 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01162192 0,10878294 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01162192 0,10836774 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01162192 0,1079557 ! neuron fate determination GO:0048664 7 5 0,000 0,01162192 0,10754677 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01162192 0,10714094 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01162192 0,10673815 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01162192 0,10633838 ! polyol transport GO:0015791 12 5 0,000 0,01162192 0,1059416 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01162192 0,10554776 ! response to superoxide GO:0000303 10 5 0,000 0,01162192 0,10515685 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01162192 0,10476881 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01162192 0,10438363 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01162192 0,10400128 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01162192 0,10362171 ! female meiosis GO:0007143 10 5 0,000 0,01162192 0,1032449 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01162192 0,10287083 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01162192 0,10249945 ! hypothalamus development GO:0021854 9 5 0,000 0,01162192 0,10213075 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01162192 0,10176469 ! cobalt ion transport GO:0006824 11 5 0,000 0,01162192 0,10140124 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01162192 0,10104039 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01162192 0,10068209 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01162192 0,10032632 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,01162192 0,09997306 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01162192 0,09962228 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01162192 0,09927395 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01162192 0,09892804 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01162192 0,09858454 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01162192 0,09824342 ! transposition GO:0032196 9 5 0,000 0,01162192 0,09790465 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01162192 0,09756821 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01162192 0,09723407 ! negative chemotaxis GO:0050919 16 5 0,000 0,01162192 0,09690221 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01162192 0,09657261 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01162192 0,09624525 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01162192 0,0959201 ! behavioral response to pain GO:0048266 10 5 0,000 0,01162192 0,09559713 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01162192 0,09527634 ! Notch receptor processing GO:0007220 11 5 0,000 0,01162192 0,09495769 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01162192 0,09464116 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01162192 0,09432674 ! micturition GO:0060073 9 5 0,000 0,01162192 0,0940144 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01162192 0,09370412 ! copulation GO:0007620 9 5 0,000 0,01162192 0,09339588 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01162192 0,09308967 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,01162192 0,09278545 ! bioluminescence GO:0008218 9 5 0,000 0,01162192 0,09248322 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01162192 0,09218295 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01162192 0,09188462 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01162192 0,09158822 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01162192 0,09129373 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01162192 0,09100112 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01162192 0,09071038 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01162192 0,09042149 ! grooming behavior GO:0007625 6 5 0,000 0,01162192 0,09013444 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01162192 0,0898492 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01162192 0,08956577 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01162192 0,08928411 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01162192 0,08900423 ! response to protozoan GO:0001562 13 5 0,000 0,01162192 0,08872609 ! lymph vessel development GO:0001945 10 5 0,000 0,01162192 0,08844968 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01162192 0,088175 ! endochondral ossification GO:0001958 17 5 0,000 0,01162192 0,08790201 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01162192 0,08763071 ! single strand break repair GO:0000012 8 5 0,000 0,01162192 0,08736107 ! parathyroid gland development GO:0060017 14 5 0,000 0,01162192 0,08709309 ! anagen GO:0042640 7 5 0,000 0,01162192 0,08682675 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01162192 0,08656204 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01162192 0,08629893 ! cytokine secretion GO:0050663 15 5 0,000 0,01162192 0,08603742 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01162192 0,08577749 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01162192 0,08551912 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01162192 0,08526231 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01162192 0,08500703 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01162192 0,08475328 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01162192 0,08450104 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01162192 0,08425029 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01162192 0,08400103 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01162192 0,08375324 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01162192 0,08350691 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01162192 0,08326202 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01162192 0,08301856 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01162192 0,08277653 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01162192 0,0825359 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01162192 0,08229666 ! microvillus organization GO:0032528 8 5 0,000 0,01162192 0,08205881 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 12 5 0,000 0,01162192 0,08182233 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01162192 0,08158721 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01162192 0,08135343 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01162192 0,081121 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01162192 0,08088988 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01162192 0,08066008 ! polyol catabolic process GO:0046174 9 5 0,000 0,01162192 0,08043158 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01162192 0,08020437 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01162192 0,07997845 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01162192 0,07975379 ! muscle cell migration GO:0014812 8 5 0,000 0,01162192 0,07953039 ! mitochondrial fission GO:0000266 8 5 0,000 0,01162192 0,07930824 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,01162192 0,07908732 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01162192 0,07886763 ! mRNA transcription GO:0009299 10 5 0,000 0,01162192 0,07864916 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01162192 0,0784319 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01162192 0,07821584 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01162192 0,07800096 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01162192 0,07778726 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,01162192 0,07757472 ! monocyte activation GO:0042117 10 5 0,000 0,01162192 0,07736335 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01162192 0,07715312 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01162192 0,07694403 ! response to food GO:0032094 6 5 0,000 0,01162192 0,07673608 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01162192 0,07652924 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01162192 0,07632352 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01162192 0,0761189 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01162192 0,07591537 ! forebrain neuron development GO:0021884 13 5 0,000 0,01162192 0,07571293 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01162192 0,07551157 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01162192 0,07531127 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01162192 0,07511203 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01162192 0,07491385 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01162192 0,07471671 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01162192 0,0745206 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01162192 0,07432552 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01162192 0,07413146 ! lipid glycosylation GO:0030259 7 5 0,000 0,01162192 0,07393841 ! nucleobase transport GO:0015851 6 5 0,000 0,01162192 0,07374636 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01162192 0,07355531 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01162192 0,07336524 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01162192 0,07317616 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01162192 0,07298804 ! basic amino acid transport GO:0015802 12 5 0,000 0,01162192 0,07280089 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01162192 0,0726147 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01162192 0,07242946 ! actin nucleation GO:0045010 11 5 0,000 0,01162192 0,07224516 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01162192 0,0720618 ! depurination GO:0045007 5 5 0,000 0,01162192 0,07187936 ! depyrimidination GO:0045008 10 5 0,000 0,01162192 0,07169785 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01162192 0,07151725 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01162192 0,07133756 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01162192 0,07115877 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01162192 0,07098087 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01162192 0,07080386 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01162192 0,07062773 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01162192 0,07045248 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01162192 0,07027809 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01162192 0,07010456 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01162192 0,06993189 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01162192 0,06976007 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01162192 0,06958909 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01162192 0,06941895 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01162192 0,06924963 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01162192 0,06908114 ! response to arsenic GO:0046685 11 5 0,000 0,01162192 0,06891347 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01162192 0,06874661 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01162192 0,06858055 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01162192 0,0684153 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01162192 0,06825084 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01162192 0,06808717 ! response to mercury ion GO:0046689 8 5 0,000 0,01162192 0,06792428 ! response to cadmium ion GO:0046686 7 5 0,000 0,01162192 0,06776217 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01162192 0,06760083 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01162192 0,06744026 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01162192 0,06728045 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01162192 0,06712139 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01162192 0,06696309 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01162192 0,06680553 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01162192 0,06664871 ! decidualization GO:0046697 11 5 0,000 0,01162192 0,06649262 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01162192 0,06633726 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01162192 0,06618263 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01162192 0,06602872 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01162192 0,06587552 ! embryonic cleavage GO:0040016 6 5 0,000 0,01162192 0,06572303 ! peroxisome fission GO:0016559 5 5 0,000 0,01162192 0,06557124 ! histone demethylation GO:0016577 13 5 0,000 0,01162192 0,06542016 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01162192 0,06526977 ! mitotic recombination GO:0006312 9 5 0,000 0,01162192 0,06512007 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01162192 0,06497105 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01162192 0,06482271 ! metaphase plate congression GO:0051310 7 5 0,000 0,01162192 0,06467505 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01162192 0,06452806 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01162192 0,06438174 ! enteric nervous system development GO:0048484 8 5 0,000 0,01162192 0,06423608 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01162192 0,06409108 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01162192 0,06394673 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01162192 0,06380303 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01162192 0,06365997 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01162192 0,06351756 ! B cell homeostasis GO:0001782 13 5 0,000 0,01162192 0,06337578 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01162192 0,06323463 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01162192 0,06309411 ! metaphase GO:0051323 11 5 0,000 0,01162192 0,06295421 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01162192 0,06281493 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01162192 0,06267627 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01162192 0,06253821 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01162192 0,06240077 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01162192 0,06226392 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01162192 0,06212768 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01162192 0,06199203 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01162192 0,06185697 ! response to redox state GO:0051775 6 5 0,000 0,01162192 0,0617225 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01162192 0,06158861 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01162192 0,0614553 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01162192 0,06132257 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01162192 0,06119041 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01162192 0,06105881 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01162192 0,06092779 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01162192 0,06079732 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01162192 0,06066741 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01162192 0,06053806 ! striatum development GO:0021756 14 5 0,000 0,01162192 0,06040925 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01162192 0,06028099 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01162192 0,06015328 ! glial cell migration GO:0008347 10 5 0,000 0,01162192 0,06002611 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01162192 0,05989947 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01162192 0,05977337 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01162192 0,05964779 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01162192 0,05952274 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01162192 0,05939822 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01162192 0,05927421 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01162192 0,05915073 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01162192 0,05902775 ! neuroprotection GO:0043526 8 5 0,000 0,01162192 0,05890529 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01162192 0,05878333 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01162192 0,05866188 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01162192 0,05854092 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01162192 0,05842047 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01162192 0,05830051 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01162192 0,05818104 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01162192 0,05806206 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01162192 0,05794357 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,01162192 0,05782556 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01162192 0,05770803 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01162192 0,05759097 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01162192 0,05747439 ! spindle assembly GO:0051225 6 5 0,000 0,01162192 0,05735828 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01162192 0,05724264 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01162192 0,05712746 ! protein palmitoylation GO:0018345 12 5 0,000 0,01162192 0,05701275 ! drug metabolic process GO:0017144 7 5 0,000 0,01162192 0,05689849 ! stem cell division GO:0017145 11 5 0,000 0,01162192 0,0567847 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01162192 0,05667135 ! organ regeneration GO:0031100 7 5 0,000 0,01162192 0,05655846 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01162192 0,05644602 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01162192 0,05633402 ! appendage morphogenesis GO:0035107 150 72 1,000 0,01238743 0,05992575 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 171 72 1,000 0,01238743 0,05980732 ! appendage development GO:0048736 151 73 1,000 0,01271726 0,06127862 GO:0060173|limb development, ! regulation of caspase activity GO:0043281 136 74 1,000 0,0130509 0,0627625 ! respiratory system development GO:0060541 175 74 1,000 0,0130509 0,06263919 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,01338834 0,06413277 GO:0090046|regulation of transcription regulator activity, ! phosphoinositide-mediated signaling GO:0048015 141 75 1,000 0,01338834 0,06400726 ! axon guidance GO:0007411 162 75 1,000 0,01338834 0,06388225 ! learning or memory GO:0007611 161 76 1,000 0,01372956 0,06538266 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,01393024 0,06620929 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,01393024 0,06608073 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,01393024 0,06595266 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,01393024 0,06582509 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,01393024 0,06569802 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,01393024 0,06557143 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,01393024 0,06544533 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,01393024 0,06531972 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,01393024 0,06519459 ! response to oxygen radical GO:0000305 11 6 0,000 0,01393024 0,06506993 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,01393024 0,06494575 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,01393024 0,06482205 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,01393024 0,06469881 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,01393024 0,06457604 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,01393024 0,06445374 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,01393024 0,0643319 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,01393024 0,06421052 ! forebrain regionalization GO:0021871 9 6 0,000 0,01393024 0,06408959 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,01393024 0,06396912 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,01393024 0,06384911 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,01393024 0,06372954 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,01393024 0,06361042 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,01393024 0,06349174 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,01393024 0,06337351 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,01393024 0,06325571 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,01393024 0,06313836 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,01393024 0,06302143 ! malate metabolic process GO:0006108 13 6 0,000 0,01393024 0,06290494 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,01393024 0,06278888 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,01393024 0,06267325 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,01393024 0,06255804 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,01393024 0,06244326 ! protein refolding GO:0042026 15 6 0,000 0,01393024 0,06232889 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,01393024 0,06221494 ! opsonization GO:0008228 8 6 0,000 0,01393024 0,06210141 ! mating behavior GO:0007617 7 6 0,000 0,01393024 0,0619883 ! erythrocyte maturation GO:0043249 8 6 0,000 0,01393024 0,06187559 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,01393024 0,06176329 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,01393024 0,0616514 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,01393024 0,06153992 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,01393024 0,06142883 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,01393024 0,06131815 ! response to interferon-gamma GO:0034341 16 6 0,000 0,01393024 0,06120787 ! toxin metabolic process GO:0009404 11 6 0,000 0,01393024 0,06109798 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,01393024 0,06098848 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,01393024 0,06087938 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,01393024 0,06077067 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,01393024 0,06066234 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,01393024 0,0605544 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,01393024 0,06044685 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,01393024 0,06033967 ! thymic T cell selection GO:0045061 16 6 0,000 0,01393024 0,06023287 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,01393024 0,06012646 ! protein lipoylation GO:0009249 10 6 0,000 0,01393024 0,06002041 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,01393024 0,05991474 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,01393024 0,05980944 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,01393024 0,05970452 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,01393024 0,05959995 ! glutamate catabolic process GO:0006538 12 6 0,000 0,01393024 0,05949576 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,01393024 0,05939193 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,01393024 0,05928846 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,01393024 0,05918535 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,01393024 0,05908259 ! hyperosmotic response GO:0006972 10 6 0,000 0,01393024 0,0589802 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,01393024 0,05887816 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,01393024 0,05877647 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,01393024 0,05867513 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,01393024 0,05857414 ! urea metabolic process GO:0019627 7 6 0,000 0,01393024 0,05847349 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,01393024 0,0583732 ! neutrophil activation GO:0042119 7 6 0,000 0,01393024 0,05827324 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,01393024 0,05817363 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,01393024 0,05807436 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,01393024 0,05797542 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,01393024 0,05787683 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,01393024 0,05777856 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,01393024 0,05768063 ! neuron apoptosis GO:0051402 15 6 0,000 0,01393024 0,05758304 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,01393024 0,05748577 ! T cell mediated immunity GO:0002456 17 6 0,000 0,01393024 0,05738883 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,01393024 0,05729221 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,01393024 0,05719592 ! carnitine transport GO:0015879 10 6 0,000 0,01393024 0,05709996 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01393024 0,05700431 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,01393024 0,05690899 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,01393024 0,05681398 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,01393024 0,05671929 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,01393024 0,05662492 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,01393024 0,05653085 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,01393024 0,0564371 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,01393024 0,05634367 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,01393024 0,05625054 ! establishment of spindle localization GO:0051293 16 6 0,000 0,01393024 0,05615771 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,01393024 0,0560652 ! neural nucleus development GO:0048857 19 6 0,000 0,01393024 0,05597298 ! response to UV-C GO:0010225 14 6 0,000 0,01393024 0,05588107 ! astrocyte development GO:0014002 16 6 0,000 0,01393024 0,05578947 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,01393024 0,05569816 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,01393024 0,05560715 ! interaction with symbiont GO:0051702 14 6 0,000 0,01393024 0,05551643 ! regulation of dendrite development GO:0050773 16 6 0,000 0,01393024 0,05542602 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,01393024 0,05533589 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,01393024 0,05524606 ! response to copper ion GO:0046688 10 6 0,000 0,01393024 0,05515652 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,01393024 0,05506727 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,01393024 0,05497831 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01393024 0,05488964 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,01393024 0,05480125 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,01393024 0,05471314 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,01393024 0,05462532 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,01393024 0,05453778 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,01393024 0,05445052 ! hair follicle maturation GO:0048820 8 6 0,000 0,01393024 0,05436354 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,01393024 0,05427683 ! Schwann cell development GO:0014044 15 6 0,000 0,01393024 0,0541904 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,01393024 0,05410425 ! response to pheromone GO:0019236 6 6 0,000 0,01393024 0,05401837 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,01393024 0,05393276 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,01393024 0,05384743 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,01393024 0,05376236 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,01393024 0,05367756 ! subpallium development GO:0021544 15 6 0,000 0,01393024 0,05359303 ! neural tube patterning GO:0021532 8 6 0,000 0,01393024 0,05350876 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,01393024 0,05342476 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,01393024 0,05334103 ! maintenance of organ identity GO:0048496 9 6 0,000 0,01393024 0,05325755 ! G2 phase GO:0051319 16 6 0,000 0,01393024 0,05317433 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,01393024 0,05309138 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,01393024 0,05300868 ! oxygen homeostasis GO:0032364 10 6 0,000 0,01393024 0,05292624 ! establishment of planar polarity GO:0001736 7 6 0,000 0,01393024 0,05284406 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,01393024 0,05276213 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,01393024 0,05268046 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,01393024 0,05259903 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,01393024 0,05251786 ! receptor internalization GO:0031623 11 6 0,000 0,01393024 0,05243694 ! plasminogen activation GO:0031639 9 6 0,000 0,01393024 0,05235627 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,01393024 0,05227584 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01393024 0,05219567 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,01393024 0,05211573 ! protein deubiquitination GO:0016579 16 6 0,000 0,01393024 0,05203605 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,01393024 0,0519566 ! protein destabilization GO:0031648 9 6 0,000 0,01393024 0,0518774 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,01393024 0,05179844 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,01393024 0,05171972 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,01393024 0,05164124 ! regulation of viral transcription GO:0046782 11 6 0,000 0,01393024 0,05156299 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,01393024 0,05148498 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,01393024 0,05140721 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,01393024 0,05132967 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,01393024 0,05125237 ! determination of adult lifespan GO:0008340 17 6 0,000 0,01393024 0,0511753 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,01393024 0,05109846 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,01393024 0,05102185 ! neural plate development GO:0001840 9 6 0,000 0,01393024 0,05094547 ! catecholamine transport GO:0051937 9 6 0,000 0,01393024 0,05086932 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,01393024 0,05079339 ! sensory cilium assembly GO:0035058 10 6 0,000 0,01393024 0,0507177 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,01393024 0,05064222 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,01393024 0,05056697 ! maternal placenta development GO:0001893 12 6 0,000 0,01393024 0,05049195 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,01393024 0,05041715 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,01393024 0,05034257 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,01393024 0,0502682 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,01393024 0,05019406 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,01393024 0,05012014 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,01393024 0,05004643 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,01393024 0,04997294 GO:0055081|anion homeostasis, ! phosphoinositide metabolic process GO:0030384 146 77 1,000 0,01407453 0,05041655 ! regulation of endopeptidase activity GO:0052548 141 77 1,000 0,01407453 0,05034273 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,01442325 0,05151463 ! activation of protein kinase activity GO:0032147 170 80 1,000 0,01513184 0,05396654 ! meiosis GO:0007126 143 81 1,000 0,01549167 0,0551693 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 1,000 0,01549167 0,055089 ! response to hypoxia GO:0001666 178 81 1,000 0,01549167 0,05500893 ! positive regulation of phosphorylation GO:0042327 149 81 1,000 0,01549167 0,05492909 ! regulation of peptidase activity GO:0052547 150 82 1,000 0,01585516 0,05613646 ! meiotic cell cycle GO:0051321 144 82 1,000 0,01585516 0,05605522 ! response to oxygen levels GO:0070482 183 83 1,000 0,0162223 0,05727035 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 1,000 0,0162223 0,05718771 GO:0045937|positive regulation of phosphate metabolic process, ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,0162223 0,05710531 ! tRNA transcription GO:0009304 17 7 0,000 0,01623323 0,05706156 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,01623323 0,05697958 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,01623323 0,05689783 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,01623323 0,05681631 ! regulation of helicase activity GO:0051095 16 7 0,000 0,01623323 0,05673503 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,01623323 0,05665398 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,01623323 0,05657316 ! sleep GO:0030431 16 7 0,000 0,01623323 0,05649258 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,01623323 0,05641222 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,01623323 0,05633208 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,01623323 0,05625218 ! prostate gland development GO:0030850 14 7 0,000 0,01623323 0,0561725 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,01623323 0,05609305 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01623323 0,05601382 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,01623323 0,05593482 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,01623323 0,05585604 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01623323 0,05577748 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,01623323 0,05569914 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,01623323 0,05562102 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,01623323 0,05554312 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,01623323 0,05546544 ! glycolipid transport GO:0046836 11 7 0,000 0,01623323 0,05538797 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,01623323 0,05531072 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,01623323 0,05523369 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,01623323 0,05515687 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,01623323 0,05508026 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,01623323 0,05500387 ! mRNA stabilization GO:0048255 18 7 0,000 0,01623323 0,05492768 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,01623323 0,05485171 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,01623323 0,05477595 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,01623323 0,0547004 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,01623323 0,05462505 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,01623323 0,05454991 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,01623323 0,05447498 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,01623323 0,05440026 ! lipoprotein transport GO:0042953 14 7 0,000 0,01623323 0,05432574 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,01623323 0,05425142 ! rhythmic behavior GO:0007622 17 7 0,000 0,01623323 0,05417731 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,01623323 0,05410339 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,01623323 0,05402968 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,01623323 0,05395617 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,01623323 0,05388286 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,01623323 0,05380975 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,01623323 0,05373684 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,01623323 0,05366412 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,01623323 0,0535916 ! mechanosensory behavior GO:0007638 16 7 0,000 0,01623323 0,05351928 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,01623323 0,05344715 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,01623323 0,05337522 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,01623323 0,05330348 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,01623323 0,05323193 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01623323 0,05316057 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01623323 0,05308941 ! spinal cord patterning GO:0021511 14 7 0,000 0,01623323 0,05301843 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,01623323 0,05294765 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,01623323 0,05287705 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,01623323 0,05280664 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,01623323 0,05273642 ! adrenal gland development GO:0030325 17 7 0,000 0,01623323 0,05266638 ! cysteine metabolic process GO:0006534 13 7 0,000 0,01623323 0,05259654 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,01623323 0,05252687 ! ovulation GO:0030728 10 7 0,000 0,01623323 0,05245739 ! adenohypophysis development GO:0021984 11 7 0,000 0,01623323 0,05238809 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,01623323 0,05231898 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,01623323 0,05225005 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,01623323 0,0521813 ! microtubule nucleation GO:0007020 21 7 0,000 0,01623323 0,05211273 ! proline biosynthetic process GO:0006561 10 7 0,000 0,01623323 0,05204434 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,01623323 0,05197613 ! thyroid hormone generation GO:0006590 13 7 0,000 0,01623323 0,0519081 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,01623323 0,05184025 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,01623323 0,05177257 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01623323 0,05170507 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,01623323 0,05163774 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,01623323 0,0515706 ! galactose metabolic process GO:0006012 13 7 0,000 0,01623323 0,05150362 ! vesicle fusion GO:0006906 20 7 0,000 0,01623323 0,05143682 ! response to dietary excess GO:0002021 8 7 0,000 0,01623323 0,05137019 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,01623323 0,05130374 ! intracellular pH reduction GO:0051452 13 7 0,000 0,01623323 0,05123745 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,01623323 0,05117134 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,01623323 0,0511054 ! organ growth GO:0035265 15 7 0,000 0,01623323 0,05103962 ! nucleoside transport GO:0015858 11 7 0,000 0,01623323 0,05097402 ! nucleoside salvage GO:0043174 11 7 0,000 0,01623323 0,05090858 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,01623323 0,05084332 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,01623323 0,05077822 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,01623323 0,05071328 ! parturition GO:0007567 16 7 0,000 0,01623323 0,05064852 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,01623323 0,05058391 ! rRNA modification GO:0000154 14 7 0,000 0,01623323 0,05051947 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,01623323 0,0504552 ! spindle checkpoint GO:0031577 16 7 0,000 0,01623323 0,05039109 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,01623323 0,05032714 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,01623323 0,05026336 ! monocyte differentiation GO:0030224 16 7 0,000 0,01623323 0,05019973 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,01623323 0,05013627 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,01623323 0,05007296 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,01623323 0,05000982 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,01623323 0,04994684 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,01623323 0,04988401 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,01623323 0,04982134 ! fibrinolysis GO:0042730 11 7 0,000 0,01623323 0,04975883 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,01623323 0,04969648 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,01623323 0,04963428 ! eating behavior GO:0042755 8 7 0,000 0,01623323 0,04957223 ! B cell lineage commitment GO:0002326 21 7 0,000 0,01623323 0,04951035 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,01623323 0,04944861 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,01623323 0,04938703 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,01623323 0,04932561 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,01623323 0,04926433 ! negative regulation of focal adhesion formation GO:0051895 21 7 0,000 0,01623323 0,04920321 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,01623323 0,04914224 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,01623323 0,04908142 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,01623323 0,04902075 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,01623323 0,04896023 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,01623323 0,04889986 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,01623323 0,04883964 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,01623323 0,04877957 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,01623323 0,04871964 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,01623323 0,04865986 ! histone ubiquitination GO:0016574 9 7 0,000 0,01623323 0,04860023 ! regulation of meiosis GO:0040020 12 7 0,000 0,01623323 0,04854074 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,01623323 0,0484814 ! T cell lineage commitment GO:0002360 16 7 0,000 0,01623323 0,04842221 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,01623323 0,04836316 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,01623323 0,04830425 ! membrane to membrane docking GO:0022614 14 7 0,000 0,01623323 0,04824548 ! transcription termination GO:0006353 14 7 0,000 0,01623323 0,04818686 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,01623323 0,04812838 ! anaphase GO:0051322 18 7 0,000 0,01623323 0,04807005 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,01623323 0,04801185 ! axonal fasciculation GO:0007413 19 7 0,000 0,01623323 0,04795379 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,01623323 0,04789588 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,01623323 0,0478381 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,01623323 0,04778047 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,01623323 0,04772297 ! diuresis GO:0030146 12 7 0,000 0,01623323 0,04766561 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,01623323 0,04760839 ! thiamin metabolic process GO:0006772 7 7 0,000 0,01623323 0,0475513 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01623323 0,04749436 ! antibiotic transport GO:0042891 9 7 0,000 0,01623323 0,04743755 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,01623323 0,04738087 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,01623323 0,04732433 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,01623323 0,04726792 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,01623323 0,04721165 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,01623323 0,04715551 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,01623323 0,04709951 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,01623323 0,04704364 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,01623323 0,0469879 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,01623323 0,04693229 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,01623323 0,04687682 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,01623323 0,04682147 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,01623323 0,04676626 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,01623323 0,04671118 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,01623323 0,04665622 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,01623323 0,0466014 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,01623323 0,0465467 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,01623323 0,04649213 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,01623323 0,04643769 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,01623323 0,04638338 ! muscle adaptation GO:0043500 13 7 0,000 0,01623323 0,04632919 ! embryonic heart tube development GO:0035050 14 7 0,000 0,01623323 0,04627513 ! retina homeostasis GO:0001895 12 7 0,000 0,01623323 0,0462212 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,01623323 0,04616739 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,01623323 0,04611371 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,01623323 0,04606015 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,01623323 0,04600671 ! response to nutrient GO:0007584 135 84 1,000 0,01659307 0,04697205 ! negative regulation of transport GO:0051051 164 85 1,000 0,01696745 0,04797626 ! negative regulation of growth GO:0045926 168 85 1,000 0,01696745 0,04792079 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,01696745 0,04786546 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,01734542 0,04887528 GO:0002696|positive regulation of leukocyte activation, ! nucleosome assembly GO:0006334 126 87 1,000 0,01772697 0,04989284 ! chromatin assembly GO:0031497 128 88 1,000 0,01811207 0,05091804 ! one-carbon metabolic process GO:0006730 167 88 1,000 0,01811207 0,05085952 ! regulation of DNA binding GO:0051101 167 89 1,000 0,0185007 0,05189118 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,01853091 0,05191631 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,01853091 0,05185684 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,01853091 0,0517975 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,01853091 0,05173831 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,01853091 0,05167925 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,01853091 0,05162032 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,01853091 0,05156153 ! male meiosis GO:0007140 9 8 0,000 0,01853091 0,05150287 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,01853091 0,05144434 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,01853091 0,05138595 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,01853091 0,05132769 ! meiotic prophase I GO:0007128 14 8 0,000 0,01853091 0,05126956 ! response to zinc ion GO:0010043 12 8 0,000 0,01853091 0,05121156 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,01853091 0,05115369 ! oligopeptide transport GO:0006857 16 8 0,000 0,01853091 0,05109596 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,01853091 0,05103835 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,01853091 0,05098088 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,01853091 0,05092353 ! signal peptide processing GO:0006465 12 8 0,000 0,01853091 0,05086631 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,01853091 0,05080922 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,01853091 0,05075226 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,01853091 0,05069543 ! succinate metabolic process GO:0006105 17 8 0,000 0,01853091 0,05063872 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,01853091 0,05058214 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,01853091 0,05052569 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,01853091 0,05046936 ! estrogen metabolic process GO:0008210 17 8 0,000 0,01853091 0,05041316 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,01853091 0,05035708 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,01853091 0,05030113 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,01853091 0,0502453 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,01853091 0,0501896 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01853091 0,05013402 ! reflex GO:0060004 17 8 0,000 0,01853091 0,05007856 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,01853091 0,05002323 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,01853091 0,04996801 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,01853091 0,04991292 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,01853091 0,04985795 ! pigment granule organization GO:0048753 17 8 0,000 0,01853091 0,0498031 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,01853091 0,04974837 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,01853091 0,04969376 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,01853091 0,04963928 ! astrocyte differentiation GO:0048708 19 8 0,000 0,01853091 0,04958491 ! histidine catabolic process GO:0006548 10 8 0,000 0,01853091 0,04953066 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,01853091 0,04947652 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,01853091 0,04942251 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,01853091 0,04936861 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,01853091 0,04931484 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,01853091 0,04926117 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,01853091 0,04920763 ! melanin metabolic process GO:0006582 17 8 0,000 0,01853091 0,0491542 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,01853091 0,04910089 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,01853091 0,04904769 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,01853091 0,04899461 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,01853091 0,04894164 ! macrophage activation GO:0042116 13 8 0,000 0,01853091 0,04888879 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,01853091 0,04883605 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,01853091 0,04878343 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,01853091 0,04873091 ! purine salvage GO:0043101 12 8 0,000 0,01853091 0,04867852 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,01853091 0,04862623 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01853091 0,04857405 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,01853091 0,04852199 ! osteoblast development GO:0002076 17 8 0,000 0,01853091 0,04847004 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,01853091 0,0484182 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,01853091 0,04836647 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,01853091 0,04831485 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,01853091 0,04826335 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,01853091 0,04821195 ! response to UV-B GO:0010224 17 8 0,000 0,01853091 0,04816066 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,01853091 0,04810948 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,01853091 0,04805841 ! intermediate filament organization GO:0045109 12 8 0,000 0,01853091 0,04800744 ! cellular extravasation GO:0045123 13 8 0,000 0,01853091 0,04795659 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,01853091 0,04790584 ! response to antibiotic GO:0046677 11 8 0,000 0,01853091 0,0478552 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,01853091 0,04780467 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,01853091 0,04775424 ! DNA topological change GO:0006265 12 8 0,000 0,01853091 0,04770392 ! response to tropane GO:0014073 15 8 0,000 0,01853091 0,0476537 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,01853091 0,0476036 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,01853091 0,04755359 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,01853091 0,04750369 ! mast cell activation GO:0045576 14 8 0,000 0,01853091 0,0474539 ! multicellular organismal aging GO:0010259 20 8 0,000 0,01853091 0,04740421 ! regulation of focal adhesion formation GO:0051893 23 8 0,000 0,01853091 0,04735462 ! gas homeostasis GO:0033483 14 8 0,000 0,01853091 0,04730514 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,01853091 0,04725576 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,01853091 0,04720648 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,01853091 0,04715731 ! nucleosome disassembly GO:0006337 14 8 0,000 0,01853091 0,04710824 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,01853091 0,04705927 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,01853091 0,0470104 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,01853091 0,04696164 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,01853091 0,04691297 ! intracellular lipid transport GO:0032365 16 8 0,000 0,01853091 0,04686441 ! response to tumor cell GO:0002347 16 8 0,000 0,01853091 0,04681595 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,01853091 0,04676758 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,01853091 0,04671932 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,01853091 0,04667115 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,01853091 0,04662309 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,01853091 0,04657512 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,01853091 0,04652725 ! hormone catabolic process GO:0042447 17 8 0,000 0,01853091 0,04647949 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,01853091 0,04643181 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,01853091 0,04638424 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,01853091 0,04633676 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,01853091 0,04628939 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,01853091 0,0462421 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,01853091 0,04619492 ! adult feeding behavior GO:0008343 10 8 0,000 0,01853091 0,04614783 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,01853091 0,04610083 ! ATP catabolic process GO:0006200 11 8 0,000 0,01853091 0,04605394 ! blastocyst growth GO:0001832 19 8 0,000 0,01853091 0,04600713 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,01853091 0,04596043 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,01853091 0,04591381 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,01853091 0,04586729 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,01853091 0,04582087 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,01853091 0,04577454 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,01853091 0,0457283 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,01853091 0,04568216 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,01853091 0,04563611 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,01853091 0,04559015 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,01853091 0,04554428 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,01853091 0,04549851 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,01853091 0,04545283 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,01853091 0,04540724 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,01853091 0,04536174 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,01853091 0,04531634 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,01853091 0,04527102 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,01853091 0,04522579 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,01853091 0,04518066 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,01853091 0,04513561 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,01853091 0,04509066 ! response to unfolded protein GO:0006986 139 90 1,000 0,01889286 0,04592562 ! gland development GO:0048732 220 91 1,000 0,01928851 0,04684079 ! protein-DNA complex assembly GO:0065004 134 92 1,000 0,01968765 0,04776258 ! regulation of cell adhesion GO:0030155 241 92 1,000 0,01968765 0,0477152 ! vitamin metabolic process GO:0006766 153 93 1,000 0,02009025 0,04864269 ! female pregnancy GO:0007565 166 94 1,000 0,02049629 0,04957668 ! regulation of membrane potential GO:0042391 179 94 1,000 0,02049629 0,04952764 ! axon extension GO:0048675 16 9 0,000 0,02082329 0,05026808 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,02082329 0,05021846 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,02082329 0,05016893 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,02082329 0,05011951 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,02082329 0,05007017 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,02082329 0,05002094 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,02082329 0,04997181 ! reproductive behavior GO:0019098 22 9 0,000 0,02082329 0,04992277 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,02082329 0,04987382 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,02082329 0,04982497 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,02082329 0,04977622 ! UTP metabolic process GO:0046051 10 9 0,000 0,02082329 0,04972756 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,02082329 0,049679 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,02082329 0,04963053 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,02082329 0,04958216 ! artery development GO:0060840 25 9 0,000 0,02082329 0,04953388 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,02082329 0,0494857 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,02082329 0,04943761 ! equilibrioception GO:0050957 20 9 0,000 0,02082329 0,04938961 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,02082329 0,0493417 ! chemosensory behavior GO:0007635 21 9 0,000 0,02082329 0,04929389 ! microtubule bundle formation GO:0001578 22 9 0,000 0,02082329 0,04924617 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,02082329 0,04919855 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,02082329 0,04915101 ! leukocyte degranulation GO:0043299 16 9 0,000 0,02082329 0,04910357 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,02082329 0,04905622 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,02082329 0,04900896 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,02082329 0,04896179 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,02082329 0,04891471 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,02082329 0,04886772 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,02082329 0,04882082 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,02082329 0,04877402 ! protein targeting to ER GO:0045047 25 9 0,000 0,02082329 0,0487273 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,02082329 0,04868067 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,02082329 0,04863413 ! T cell selection GO:0045058 27 9 0,000 0,02082329 0,04858768 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,02082329 0,04854131 ! glycine catabolic process GO:0006546 15 9 0,000 0,02082329 0,04849504 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,02082329 0,04844886 ! endosome organization GO:0007032 20 9 0,000 0,02082329 0,04840276 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,02082329 0,04835675 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,02082329 0,04831082 ! mannose metabolic process GO:0006013 13 9 0,000 0,02082329 0,04826499 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,02082329 0,04821924 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,02082329 0,04817358 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,02082329 0,048128 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,02082329 0,04808251 ! receptor clustering GO:0043113 20 9 0,000 0,02082329 0,04803711 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,02082329 0,04799179 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,02082329 0,04794656 ! retinol metabolic process GO:0042572 20 9 0,000 0,02082329 0,04790141 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,02082329 0,04785635 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,02082329 0,04781137 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,02082329 0,04776648 ! oligodendrocyte development GO:0014003 11 9 0,000 0,02082329 0,04772167 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,02082329 0,04767694 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,02082329 0,0476323 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,02082329 0,04758774 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,02082329 0,04754327 ! response to amine stimulus GO:0014075 13 9 0,000 0,02082329 0,04749888 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,02082329 0,04745457 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,02082329 0,04741034 ! erythrocyte development GO:0048821 17 9 0,000 0,02082329 0,0473662 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,02082329 0,04732214 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,02082329 0,04727816 ! renal water homeostasis GO:0003091 15 9 0,000 0,02082329 0,04723426 ! postreplication repair GO:0006301 25 9 0,000 0,02082329 0,04719044 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,02082329 0,04714671 ! icosanoid secretion GO:0032309 15 9 0,000 0,02082329 0,04710305 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,02082329 0,04705948 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,02082329 0,04701599 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,02082329 0,04697257 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,02082329 0,04692924 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,02082329 0,04688599 ! sterol catabolic process GO:0016127 14 9 0,000 0,02082329 0,04684282 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,02082329 0,04679972 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,02082329 0,04675671 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,02082329 0,04671377 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,02082329 0,04667092 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 10 9 0,000 0,02082329 0,04662814 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,02082329 0,04658544 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,02082329 0,04654282 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,02082329 0,04650027 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,02082329 0,04645781 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,02082329 0,04641542 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,02082329 0,04637311 ! purine base metabolic process GO:0006144 25 9 0,000 0,02082329 0,04633087 ! pigment granule transport GO:0051904 17 9 0,000 0,02082329 0,04628872 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,02082329 0,04624663 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,02082329 0,04620463 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,02082329 0,0461627 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,02082329 0,04612085 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,02082329 0,04607907 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,02082329 0,04603737 ! mitochondrion localization GO:0051646 18 9 0,000 0,02082329 0,04599575 ! nucleosome organization GO:0034728 143 95 1,000 0,02090577 0,04613622 ! negative regulation of multicellular organismal process GO:0051241 174 95 1,000 0,02090577 0,04609458 ! response to protein stimulus GO:0051789 158 96 1,000 0,02131866 0,04696256 ! regulation of T cell activation GO:0050863 175 96 1,000 0,02131866 0,04692025 ! regulation of DNA metabolic process GO:0051052 188 97 1,000 0,02173493 0,04779338 ! hormone metabolic process GO:0042445 171 100 1,000 0,02300395 0,05053835 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,02311038 0,05072655 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,02311038 0,05068102 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,02311038 0,05063556 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,02311038 0,05059019 ! associative learning GO:0008306 21 10 0,000 0,02311038 0,0505449 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,02311038 0,05049969 ! phosphate transport GO:0006817 24 10 0,000 0,02311038 0,05045456 ! cell volume homeostasis GO:0006884 17 10 0,000 0,02311038 0,05040951 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,02311038 0,05036454 ! CTP metabolic process GO:0046036 11 10 0,000 0,02311038 0,05031966 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,02311038 0,05027485 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,02311038 0,05023012 ! GTP metabolic process GO:0046039 11 10 0,000 0,02311038 0,05018547 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,02311038 0,0501409 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,02311038 0,05009641 ! social behavior GO:0035176 29 10 0,000 0,02311038 0,050052 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,02311038 0,05000766 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,02311038 0,04996341 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,02311038 0,04991923 ! androgen metabolic process GO:0008209 17 10 0,000 0,02311038 0,04987514 ! phospholipid efflux GO:0033700 19 10 0,000 0,02311038 0,04983112 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,02311038 0,04978717 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,02311038 0,04974331 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,02311038 0,04969952 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,02311038 0,04965581 ! lung alveolus development GO:0048286 26 10 0,000 0,02311038 0,04961217 ! pathogenesis GO:0009405 17 10 0,000 0,02311038 0,04956862 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02311038 0,04952513 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,02311038 0,04948173 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,02311038 0,0494384 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,02311038 0,04939515 ! endoderm development GO:0007492 18 10 0,000 0,02311038 0,04935197 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,02311038 0,04930887 ! arginine catabolic process GO:0006527 17 10 0,000 0,02311038 0,04926584 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,02311038 0,04922289 ! proline metabolic process GO:0006560 13 10 0,000 0,02311038 0,04918001 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,02311038 0,04913721 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,02311038 0,04909448 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,02311038 0,04905183 ! V(D)J recombination GO:0033151 34 10 0,000 0,02311038 0,04900925 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,02311038 0,04896674 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,02311038 0,04892431 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,02311038 0,04888195 ! B cell proliferation GO:0042100 19 10 0,000 0,02311038 0,04883967 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,02311038 0,04879745 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,02311038 0,04875531 ! multicellular organism growth GO:0035264 19 10 0,000 0,02311038 0,04871325 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,02311038 0,04867125 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,02311038 0,04862933 ! ruffle organization GO:0031529 17 10 0,000 0,02311038 0,04858748 ! epithelial cell development GO:0002064 21 10 0,000 0,02311038 0,0485457 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,02311038 0,048504 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,02311038 0,04846236 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,02311038 0,0484208 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,02311038 0,04837931 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,02311038 0,04833789 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,02311038 0,04829654 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,02311038 0,04825526 ! copper ion homeostasis GO:0055070 13 10 0,000 0,02311038 0,04821405 ! regulation of bone resorption GO:0045124 25 10 0,000 0,02311038 0,04817291 ! brain morphogenesis GO:0048854 23 10 0,000 0,02311038 0,04813184 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,02311038 0,04809085 ! segment specification GO:0007379 15 10 0,000 0,02311038 0,04804992 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,02311038 0,04800906 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,02311038 0,04796827 ! blastoderm segmentation GO:0007350 19 10 0,000 0,02311038 0,04792755 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,02311038 0,0478869 ! response to dsRNA GO:0043331 23 10 0,000 0,02311038 0,04784632 ! DNA ligation GO:0006266 18 10 0,000 0,02311038 0,0478058 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,02311038 0,04776536 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,02311038 0,04772498 ! melanosome localization GO:0032400 16 10 0,000 0,02311038 0,04768467 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,02311038 0,04764443 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,02311038 0,04760426 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 0,000 0,02311038 0,04756416 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,02311038 0,04752412 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,02311038 0,04748415 ! induction of an organ GO:0001759 17 10 0,000 0,02311038 0,04744425 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,02311038 0,04740441 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,02311038 0,04736464 ! protein sumoylation GO:0016925 17 10 0,000 0,02311038 0,04732494 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,02311038 0,0472853 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,02311038 0,04724574 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02311038 0,04720623 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,02311038 0,04716679 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,02311038 0,04712742 ! salivary gland development GO:0007431 28 10 0,000 0,02311038 0,04708812 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,02311038 0,04704888 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,02311038 0,0470097 ! midbrain development GO:0030901 14 10 0,000 0,02311038 0,04697059 ! musculoskeletal movement GO:0050881 16 10 0,000 0,02311038 0,04693155 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,02311038 0,04689257 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,02311038 0,04685365 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,02311038 0,0468148 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,02311038 0,04677602 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,02311038 0,0467373 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,02311038 0,04669864 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,02311038 0,04666004 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,02311038 0,04662151 ! detection of calcium ion GO:0005513 24 10 0,000 0,02311038 0,04658305 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,02311038 0,04654464 ! blastocyst formation GO:0001825 18 10 0,000 0,02311038 0,0465063 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,02311038 0,04646803 ! cerebellar cortex development GO:0021695 16 10 0,000 0,02311038 0,04642981 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,02311038 0,04639166 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,02311038 0,04635357 ! response to nicotine GO:0035094 20 10 0,000 0,02311038 0,04631555 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,02311038 0,04627758 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,02311038 0,04623968 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,02539219 0,0507636 ! respiratory burst GO:0045730 17 11 0,000 0,02539219 0,05072209 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,02539219 0,05068065 ! neuron fate specification GO:0048665 18 11 0,000 0,02539219 0,05063928 ! telencephalon cell migration GO:0022029 23 11 0,000 0,02539219 0,05059797 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,02539219 0,05055674 ! thyroid gland development GO:0030878 26 11 0,000 0,02539219 0,05051557 ! synapsis GO:0007129 14 11 0,000 0,02539219 0,05047446 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,02539219 0,05043343 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,02539219 0,05039246 ! response to pain GO:0048265 27 11 0,000 0,02539219 0,05035155 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,02539219 0,05031072 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,02539219 0,05026995 ! blood vessel remodeling GO:0001974 30 11 0,000 0,02539219 0,05022924 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 0,000 0,02539219 0,0501886 GO:0010812|negative regulation of cell-substrate adhesion, ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,02539219 0,05014803 ! bone resorption GO:0045453 16 11 0,000 0,02539219 0,05010752 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,02539219 0,05006708 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,02539219 0,05002671 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,02539219 0,04998639 ! melanocyte differentiation GO:0030318 20 11 0,000 0,02539219 0,04994615 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,02539219 0,04990597 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,02539219 0,04986585 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,02539219 0,0498258 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,02539219 0,04978581 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,02539219 0,04974588 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,02539219 0,04970602 ! UV protection GO:0009650 20 11 0,000 0,02539219 0,04966623 ! adult heart development GO:0007512 16 11 0,000 0,02539219 0,04962649 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,02539219 0,04958682 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,02539219 0,04954722 ! macroautophagy GO:0016236 19 11 0,000 0,02539219 0,04950767 ! temperature homeostasis GO:0001659 18 11 0,000 0,02539219 0,04946819 ! behavioral fear response GO:0001662 27 11 0,000 0,02539219 0,04942878 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,02539219 0,04938942 ! negative regulation of ossification GO:0030279 27 11 0,000 0,02539219 0,04935013 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,02539219 0,0493109 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,02539219 0,04927174 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,02539219 0,04923263 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,02539219 0,04919359 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,02539219 0,04915461 ! regulation of organ growth GO:0046620 14 11 0,000 0,02539219 0,04911569 ! pigment granule localization GO:0051875 20 11 0,000 0,02539219 0,04907683 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,02539219 0,04903804 ! vasoconstriction GO:0042310 20 11 0,000 0,02539219 0,0489993 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,02539219 0,04896063 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,02539219 0,04892202 ! embryonic axis specification GO:0000578 19 11 0,000 0,02539219 0,04888346 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,02539219 0,04884497 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,02539219 0,04880654 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,02539219 0,04876817 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,02539219 0,04872986 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,02539219 0,04869161 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,02539219 0,04865342 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,02539219 0,04861529 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,02539219 0,04857722 ! prophase GO:0051324 17 11 0,000 0,02539219 0,04853921 ! nucleosome positioning GO:0016584 15 11 0,000 0,02539219 0,04850126 ! regulation of isotype switching GO:0045191 24 11 0,000 0,02539219 0,04846337 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,02539219 0,04842554 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,02539219 0,04838777 ! apical protein localization GO:0045176 18 11 0,000 0,02539219 0,04835005 ! acid secretion GO:0046717 20 11 0,000 0,02539219 0,0483124 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,02539219 0,0482748 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,02539219 0,04823726 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,02539219 0,04819978 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,02539219 0,04816236 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,02539219 0,04812499 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,02539219 0,04808769 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,02539219 0,04805044 ! cholesterol efflux GO:0033344 21 11 0,000 0,02539219 0,04801325 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,02539219 0,04797611 ! oocyte development GO:0048599 20 11 0,000 0,02539219 0,04793904 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,02539219 0,04790202 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,02539219 0,04786506 ! embryonic gut development GO:0048566 19 11 0,000 0,02539219 0,04782815 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,02539219 0,04779131 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,02539219 0,04775452 ! activation of innate immune response GO:0002218 16 11 0,000 0,02539219 0,04771778 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,02539219 0,0476811 ! lysogeny GO:0030069 22 11 0,000 0,02539219 0,04764448 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,02539219 0,04760792 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,02539219 0,04757141 ! sequestering of metal ion GO:0051238 15 11 0,000 0,02539219 0,04753495 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,02766873 0,05175705 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,02766873 0,05171745 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,02766873 0,05167792 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,02766873 0,05163844 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,02766873 0,05159902 ! protein complex disassembly GO:0043241 28 12 0,000 0,02766873 0,05155966 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,02766873 0,05152036 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,02766873 0,05148112 ! T cell proliferation GO:0042098 32 12 0,000 0,02766873 0,05144194 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,02766873 0,05140282 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,02766873 0,05136376 ! ventral spinal cord development GO:0021517 25 12 0,000 0,02766873 0,05132476 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,02766873 0,05128582 ! drug transport GO:0015893 16 12 0,000 0,02766873 0,05124694 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,02766873 0,05120812 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,02766873 0,05116935 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,02766873 0,05113065 ! polyamine metabolic process GO:0006595 18 12 0,000 0,02766873 0,051092 ! focal adhesion formation GO:0048041 37 12 0,000 0,02766873 0,05105341 ! mitotic spindle organization GO:0007052 23 12 0,000 0,02766873 0,05101488 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,02766873 0,05097641 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,02766873 0,05093799 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,02766873 0,05089963 ! lipid digestion GO:0044241 21 12 0,000 0,02766873 0,05086133 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,02766873 0,05082309 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02766873 0,05078491 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,02766873 0,05074678 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,02766873 0,05070871 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,02766873 0,0506707 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,02766873 0,05063274 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,02766873 0,05059485 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,02766873 0,050557 ! snRNA metabolic process GO:0016073 30 12 0,000 0,02766873 0,05051922 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,02766873 0,05048149 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,02766873 0,05044382 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,02766873 0,0504062 ! cranial nerve development GO:0021545 23 12 0,000 0,02766873 0,05036864 ! fucose catabolic process GO:0019317 25 12 0,000 0,02766873 0,05033113 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,02766873 0,05029369 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,02766873 0,05025629 ! autonomic nervous system development GO:0048483 24 12 0,000 0,02766873 0,05021895 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,02766873 0,05018167 ! zymogen activation GO:0031638 18 12 0,000 0,02766873 0,05014445 ! T cell homeostasis GO:0043029 28 12 0,000 0,02766873 0,05010727 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,02766873 0,05007016 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,02766873 0,0500331 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,02766873 0,04999609 ! oocyte differentiation GO:0009994 21 12 0,000 0,02766873 0,04995914 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,02766873 0,04992224 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,02766873 0,0498854 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,02766873 0,04984861 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,02766873 0,04981187 ! defense response to fungus GO:0050832 15 12 0,000 0,02766873 0,04977519 ! developmental induction GO:0031128 22 12 0,000 0,02766873 0,04973857 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,02766873 0,04970199 ! lamellipodium assembly GO:0030032 24 12 0,000 0,02766873 0,04966548 ! response to cold GO:0009409 17 12 0,000 0,02766873 0,04962901 ! establishment of cell polarity GO:0030010 21 12 0,000 0,02766873 0,0495926 ! regulation of synapse organization GO:0050807 18 12 0,000 0,02766873 0,04955624 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,02994002 0,05358496 ! cGMP metabolic process GO:0046068 18 13 0,000 0,02994002 0,05354574 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,02994002 0,05350657 ! regulation of chemokine production GO:0032642 18 13 0,000 0,02994002 0,05346745 ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,02994002 0,0534284 ! peroxisomal transport GO:0043574 28 13 0,000 0,02994002 0,0533894 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,02994002 0,05335046 ! cartilage condensation GO:0001502 22 13 0,000 0,02994002 0,05331157 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,02994002 0,05327274 ! organelle fusion GO:0048284 36 13 0,000 0,02994002 0,05323397 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,02994002 0,05319526 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,02994002 0,0531566 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,02994002 0,05311799 ! endocrine pancreas development GO:0031018 25 13 0,000 0,02994002 0,05307945 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,02994002 0,05304095 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,02994002 0,05300252 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,02994002 0,05296414 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,02994002 0,05292581 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,02994002 0,05288755 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,02994002 0,05284933 ! methionine metabolic process GO:0006555 31 13 0,000 0,02994002 0,05281117 ! plasma membrane organization GO:0007009 27 13 0,000 0,02994002 0,05277307 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,02994002 0,05273502 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,02994002 0,05269703 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,02994002 0,05265909 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,02994002 0,05262121 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,02994002 0,05258338 ! cytokine metabolic process GO:0042107 24 13 0,000 0,02994002 0,0525456 ! exocrine system development GO:0035272 34 13 0,000 0,02994002 0,05250788 ! asymmetric protein localization GO:0008105 24 13 0,000 0,02994002 0,05247021 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,02994002 0,0524326 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,02994002 0,05239504 ! L-glutamate transport GO:0015813 30 13 0,000 0,02994002 0,05235753 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,02994002 0,05232008 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,02994002 0,05228268 ! protein homotetramerization GO:0051289 24 13 0,000 0,02994002 0,05224534 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,02994002 0,05220805 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,02994002 0,05217081 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,02994002 0,05213363 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,02994002 0,05209649 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,02994002 0,05205941 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,02994002 0,05202239 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,02994002 0,05198541 ! histone methylation GO:0016571 29 13 0,000 0,02994002 0,05194849 ! chromatin silencing GO:0006342 29 13 0,000 0,02994002 0,05191162 ! gland morphogenesis GO:0022612 31 13 0,000 0,02994002 0,05187481 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,02994002 0,05183804 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,02994002 0,05180133 ! regulation of epidermis development GO:0045682 19 13 0,000 0,02994002 0,05176467 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,02994002 0,05172806 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,02994002 0,0516915 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,02994002 0,051655 ! spleen development GO:0048536 24 13 0,000 0,02994002 0,05161854 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,02994002 0,05158214 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,02994002 0,05154579 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,02994002 0,05150949 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,02994002 0,05147324 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,02994002 0,05143704 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,02994002 0,0514009 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,02994002 0,0513648 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,02994002 0,05132876 ! insulin secretion GO:0030073 24 13 0,000 0,02994002 0,05129276 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,02994002 0,05125682 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,02994002 0,05122092 ! acrosome reaction GO:0007340 19 13 0,000 0,02994002 0,05118508 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,02994002 0,05114928 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,02994002 0,05111354 ! rRNA transcription GO:0009303 28 14 0,000 0,03220607 0,05494374 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,03220607 0,0549054 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,03220607 0,05486711 ! water transport GO:0006833 21 14 0,000 0,03220607 0,05482887 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,03220607 0,05479069 ! non-recombinational repair GO:0000726 29 14 0,000 0,03220607 0,05475256 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,03220607 0,05471449 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,03220607 0,05467646 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,03220607 0,0546385 ! RNA polyadenylation GO:0043631 32 14 0,000 0,03220607 0,05460058 ! lipid localization GO:0010876 32 14 0,000 0,03220607 0,05456271 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,03220607 0,0545249 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,03220607 0,05448714 ! regulated secretory pathway GO:0045055 24 14 0,000 0,03220607 0,05444943 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,03220607 0,05441178 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,03220607 0,05437418 ! arginine metabolic process GO:0006525 21 14 0,000 0,03220607 0,05433662 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,03220607 0,05429913 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,03220607 0,05426168 ! regulation of heart rate GO:0002027 25 14 0,000 0,03220607 0,05422428 ! fear response GO:0042596 34 14 0,000 0,03220607 0,05418694 ! organic alcohol transport GO:0015850 29 14 0,000 0,03220607 0,05414964 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,03220607 0,0541124 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,03220607 0,05407521 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,03220607 0,05403807 ! neutral amino acid transport GO:0015804 28 14 0,000 0,03220607 0,05400098 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,03220607 0,05396395 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,03220607 0,05392696 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,03220607 0,05389002 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,03220607 0,05385314 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,03220607 0,0538163 ! regulation of cellular pH GO:0030641 27 14 0,000 0,03220607 0,05377952 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,03220607 0,05374278 ! ribosome assembly GO:0042255 18 14 0,000 0,03220607 0,0537061 ! cerebellum development GO:0021549 23 14 0,000 0,03220607 0,05366946 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,03220607 0,05363288 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,03220607 0,05359634 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,03220607 0,05355986 ! response to gamma radiation GO:0010332 30 14 0,000 0,03220607 0,05352342 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,03220607 0,05348704 ! NADP metabolic process GO:0006739 24 14 0,000 0,03220607 0,0534507 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,03220607 0,05341441 ! oxygen transport GO:0015671 22 14 0,000 0,03220607 0,05337818 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,03220607 0,05334199 ! male genitalia development GO:0030539 26 14 0,000 0,03220607 0,05330585 ! regulation of RNA stability GO:0043487 33 14 0,000 0,03220607 0,05326976 ! regulation of axon extension GO:0030516 43 14 0,000 0,03220607 0,05323372 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,03220607 0,05319772 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,03220607 0,05316178 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,03220607 0,05312588 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,03446689 0,05681688 ! lactation GO:0007595 30 15 0,000 0,03446689 0,05677857 ! reproductive cellular process GO:0048610 22 15 0,000 0,03446689 0,05674031 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,03446689 0,0567021 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,03446689 0,05666394 ! superoxide anion generation GO:0042554 22 15 0,000 0,03446689 0,05662583 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,03446689 0,05658778 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,03446689 0,05654977 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,03446689 0,05651182 ! copper ion transport GO:0006825 22 15 0,000 0,03446689 0,05647392 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,03446689 0,05643607 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,03446689 0,05639827 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,03446689 0,05636052 ! sulfate transport GO:0008272 27 15 0,000 0,03446689 0,05632282 ! response to cAMP GO:0051591 25 15 0,000 0,03446689 0,05628517 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,03446689 0,05624757 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,03446689 0,05621002 ! response to hexose stimulus GO:0009746 25 15 0,000 0,03446689 0,05617252 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,03446689 0,05613508 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,03446689 0,05609768 ! vesicle coating GO:0006901 38 15 0,000 0,03446689 0,05606033 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,03446689 0,05602303 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,03446689 0,05598578 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,03446689 0,05594858 ! regulation of exocytosis GO:0017157 26 15 0,000 0,03446689 0,05591143 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,03446689 0,05587433 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,03446689 0,05583728 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,03446689 0,05580027 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,03446689 0,05576332 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,03446689 0,05572642 ! regulation of vasodilation GO:0042312 27 15 0,000 0,03446689 0,05568956 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,03446689 0,05565275 ! histone deacetylation GO:0016575 24 15 0,000 0,03446689 0,05561599 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,03446689 0,05557928 ! water homeostasis GO:0030104 28 15 0,000 0,03446689 0,05554262 ! cofactor transport GO:0051181 30 15 0,000 0,03446689 0,05550601 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,03446689 0,05546944 ! muscle maintenance GO:0046716 26 15 0,000 0,03446689 0,05543293 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,03446689 0,05539646 ! intestinal absorption GO:0050892 31 15 0,000 0,03446689 0,05536004 ! dopamine metabolic process GO:0042417 35 15 0,000 0,03446689 0,05532366 ! heme biosynthetic process GO:0006783 33 15 0,000 0,03446689 0,05528734 ! cell killing GO:0001906 32 15 0,000 0,03446689 0,05525106 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,03446689 0,05521483 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,03446689 0,05517865 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,03446689 0,05514251 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,03446689 0,05510642 ! actin filament polymerization GO:0030041 27 15 0,000 0,03446689 0,05507038 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,03446689 0,05503439 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,03672249 0,05859768 ! positive regulation of cell size GO:0045793 29 16 0,000 0,03672249 0,05855943 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,03672249 0,05852123 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,03672249 0,05848308 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,03672249 0,05844498 ! bone remodeling GO:0046849 28 16 0,000 0,03672249 0,05840693 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,03672249 0,05836893 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,03672249 0,05833098 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,03672249 0,05829308 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,03672249 0,05825523 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,03672249 0,05821742 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,03672249 0,05817967 ! startle response GO:0001964 28 16 0,000 0,03672249 0,05814196 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,03672249 0,0581043 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,03672249 0,0580667 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,03672249 0,05802914 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,03672249 0,05799163 ! protein polyubiquitination GO:0000209 41 16 0,000 0,03672249 0,05795416 ! glutamate metabolic process GO:0006536 25 16 0,000 0,03672249 0,05791675 ! pituitary gland development GO:0021983 30 16 0,000 0,03672249 0,05787939 ! response to osmotic stress GO:0006970 27 16 0,000 0,03672249 0,05784207 ! lysosomal transport GO:0007041 31 16 0,000 0,03672249 0,0578048 ! fructose metabolic process GO:0006000 25 16 0,000 0,03672249 0,05776758 ! L-amino acid transport GO:0015807 33 16 0,000 0,03672249 0,0577304 ! stem cell development GO:0048864 46 16 0,000 0,03672249 0,05769328 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,03672249 0,0576562 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,03672249 0,05761917 ! intermediate filament-based process GO:0045103 36 16 0,000 0,03672249 0,05758219 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,03672249 0,05754525 ! negative regulation of immune response GO:0050777 38 16 0,000 0,03672249 0,05750836 ! axon cargo transport GO:0008088 46 16 0,000 0,03672249 0,05747152 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,03672249 0,05743473 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,03672249 0,05739798 ! DNA replication initiation GO:0006270 28 16 0,000 0,03672249 0,05736128 ! neuron recognition GO:0008038 40 16 0,000 0,03672249 0,05732463 ! mRNA splice site selection GO:0006376 44 16 0,000 0,03672249 0,05728802 ! tissue regeneration GO:0042246 27 16 0,000 0,03672249 0,05725147 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,03672249 0,05721495 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,03672249 0,05717849 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,03672249 0,05714207 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,03672249 0,05710569 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,03672249 0,05706937 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,03672249 0,05703309 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,03672249 0,05699685 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,03672249 0,05696066 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,03672249 0,05692452 ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,03672249 0,05688843 ! peptide hormone processing GO:0016486 27 16 0,000 0,03672249 0,05685237 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,03897289 0,06029814 ! metencephalon development GO:0022037 32 17 0,000 0,03897289 0,06025998 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,03897289 0,06022186 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,03897289 0,06018379 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,03897289 0,06014577 ! signal complex assembly GO:0007172 47 17 0,000 0,03897289 0,0601078 ! endothelial cell migration GO:0043542 31 17 0,000 0,03897289 0,06006988 ! gene silencing by RNA GO:0031047 38 17 0,000 0,03897289 0,06003201 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,03897289 0,05999418 ! glial cell development GO:0021782 28 17 0,000 0,03897289 0,0599564 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,03897289 0,05991867 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,03897289 0,05988098 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,03897289 0,05984334 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,03897289 0,05980575 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,03897289 0,05976821 ! myoblast differentiation GO:0045445 50 17 0,000 0,03897289 0,05973072 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 0,000 0,03897289 0,05969327 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,03897289 0,05965587 ! cardiac muscle tissue development GO:0048738 34 17 0,000 0,03897289 0,05961851 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,03897289 0,0595812 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,03897289 0,05954394 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,03897289 0,05950673 ! negative regulation of microtubule depolymerization GO:0007026 50 17 0,000 0,03897289 0,05946956 GO:0031114|regulation of microtubule depolymerization, ! NAD metabolic process GO:0019674 33 17 0,000 0,03897289 0,05943244 ! membrane budding GO:0006900 42 17 0,000 0,03897289 0,05939536 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,03897289 0,05935833 ! regulation of protein binding GO:0043393 33 17 0,000 0,03897289 0,05932135 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,03897289 0,05928441 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,03897289 0,05924752 ! genitalia development GO:0048806 32 17 0,000 0,03897289 0,05921067 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,03897289 0,05917387 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,03897289 0,05913712 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,03897289 0,05910041 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,03897289 0,05906375 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,03897289 0,05902713 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,03897289 0,05899056 ! steroid catabolic process GO:0006706 34 17 0,000 0,03897289 0,05895403 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,03897289 0,05891755 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,03897289 0,05888111 ! gas transport GO:0015669 26 17 0,000 0,03897289 0,05884472 ! organic cation transport GO:0015695 32 17 0,000 0,03897289 0,05880838 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,03897289 0,05877208 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,03897289 0,05873582 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,03897289 0,05869961 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,04121809 0,062043 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,04121809 0,0620048 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,04121809 0,06196664 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,04121809 0,06192853 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,04121809 0,06189047 ! adult walking behavior GO:0007628 36 18 0,000 0,04121809 0,06185245 ! patterning of blood vessels GO:0001569 43 18 0,000 0,04121809 0,06181448 ! heart looping GO:0001947 34 18 0,000 0,04121809 0,06177656 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,04121809 0,06173868 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,04121809 0,06170085 ! centrosome cycle GO:0007098 26 18 0,000 0,04121809 0,06166307 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,04121809 0,06162533 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,04121809 0,06158764 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,04121809 0,06154999 ! glycine metabolic process GO:0006544 30 18 0,000 0,04121809 0,06151239 ! glutamine metabolic process GO:0006541 29 18 0,000 0,04121809 0,06147484 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,04121809 0,06143733 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,04121809 0,06139987 ! DNA integration GO:0015074 32 18 0,000 0,04121809 0,06136245 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,04121809 0,06132508 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,04121809 0,06128776 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,04121809 0,06125048 ! neural crest cell migration GO:0001755 41 18 0,000 0,04121809 0,06121324 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,04121809 0,06117606 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,04121809 0,06113891 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,04121809 0,06110181 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,04121809 0,06106476 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,04121809 0,06102775 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,04121809 0,06099079 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,04121809 0,06095387 ! detection of bacterium GO:0016045 22 18 0,000 0,04121809 0,06091699 ! nerve development GO:0021675 34 18 0,000 0,04121809 0,06088016 ! defense response to virus GO:0051607 43 18 0,000 0,04121809 0,06084338 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,04121809 0,06080663 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 0,000 0,04121809 0,06076994 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,04345811 0,06403387 ! positive regulation of translation GO:0045727 31 19 0,000 0,04345811 0,06399527 ! negative regulation of defense response GO:0031348 27 19 0,000 0,04345811 0,06395672 ! G1 phase of mitotic cell cycle GO:0000080 39 19 0,000 0,04345811 0,06391821 ! neuron maturation GO:0042551 46 19 0,000 0,04345811 0,06387975 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,04345811 0,06384134 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,04345811 0,06380298 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,04345811 0,06376466 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,04345811 0,06372638 ! inositol metabolic process GO:0006020 33 19 0,000 0,04345811 0,06368815 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,04345811 0,06364997 ! memory GO:0007613 34 19 0,000 0,04345811 0,06361184 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,04345811 0,06357374 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,04345811 0,0635357 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,04345811 0,0634977 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,04345811 0,06345974 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,04345811 0,06342184 ! cerebral cortex development GO:0021987 40 19 0,000 0,04345811 0,06338397 ! pigmentation during development GO:0048066 42 19 0,000 0,04345811 0,06334615 ! heme metabolic process GO:0042168 40 19 0,000 0,04345811 0,06330838 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,04345811 0,06327065 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,04345811 0,06323297 ! response to fungus GO:0009620 26 19 0,000 0,04345811 0,06319533 ! peptide cross-linking GO:0018149 39 19 0,000 0,04345811 0,06315774 ! protein export from nucleus GO:0006611 40 19 0,000 0,04345811 0,06312019 ! heart process GO:0003015 32 19 0,000 0,04345811 0,06308268 GO:0060047|heart contraction, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 0,000 0,04345811 0,06304522 ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,04345811 0,06300781 ! visual learning GO:0008542 38 19 0,000 0,04345811 0,06297043 ! cellular pigmentation GO:0033059 37 19 0,000 0,04345811 0,06293311 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,04345811 0,06289583 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,04345811 0,06285859 ! vitamin transport GO:0051180 31 19 0,000 0,04345811 0,06282139 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,04345811 0,06278424 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,04345811 0,06274714 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,04345811 0,06271007 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,04345811 0,06267305 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,04345811 0,06263608 ! cilium assembly GO:0042384 38 19 0,000 0,04345811 0,06259915 ! peptide hormone secretion GO:0030072 32 19 0,000 0,04345811 0,06256226 ! protein secretion GO:0009306 45 20 0,000 0,04569295 0,0657408 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,04569295 0,06570211 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,04569295 0,06566346 ! positive regulation of ossification GO:0045778 50 20 0,000 0,04569295 0,06562486 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,04569295 0,0655863 ! skin development GO:0043588 42 20 0,000 0,04569295 0,06554779 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,04569295 0,06550932 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,04569295 0,0654709 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,04569295 0,06543252 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,04569295 0,06539419 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,04569295 0,06535591 ! bile acid metabolic process GO:0008206 34 20 0,000 0,04569295 0,06531766 ! response to alkaloid GO:0043279 38 20 0,000 0,04569295 0,06527947 ! retinoid metabolic process GO:0001523 34 20 0,000 0,04569295 0,06524131 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,04569295 0,0652032 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,04569295 0,06516514 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,04569295 0,06512712 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,04569295 0,06508915 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,04569295 0,06505122 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,04569295 0,06501333 ! actin filament bundle formation GO:0051017 47 20 0,000 0,04569295 0,06497549 ! body fluid secretion GO:0007589 33 20 0,000 0,04569295 0,06493769 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,04569295 0,06489993 ! peptide secretion GO:0002790 38 20 0,000 0,04569295 0,06486222 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,04569295 0,06482456 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,04569295 0,06478693 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,04569295 0,06474935 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,04569295 0,06471182 ! cell-cell junction organization GO:0045216 43 20 0,000 0,04569295 0,06467433 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,04569295 0,06463688 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,04569295 0,06459947 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,04569295 0,06456211 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,04569295 0,06452479 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,04569295 0,06448751 ! regulation of glucose import GO:0046324 30 20 0,000 0,04569295 0,06445028 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,04569295 0,06441309 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,04569295 0,06437594 ! negative regulation of translation GO:0017148 32 20 0,000 0,04569295 0,06433884 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,04569295 0,06430178 ! regulation of cell killing GO:0031341 46 21 0,000 0,04792264 0,0674007 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,04792264 0,06736192 ! hormone secretion GO:0046879 39 21 0,000 0,04792264 0,06732318 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,04792264 0,06728449 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,04792264 0,06724585 ! ovarian follicle development GO:0001541 39 21 0,000 0,04792264 0,06720724 ! smooth muscle contraction GO:0006939 48 21 0,000 0,04792264 0,06716868 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,04792264 0,06713017 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,04792264 0,0670917 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,04792264 0,06705327 ! plasma membrane fusion GO:0045026 33 21 0,000 0,04792264 0,06701489 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,04792264 0,06697655 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,04792264 0,06693826 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,04792264 0,06690001 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,04792264 0,0668618 ! diencephalon development GO:0021536 36 21 0,000 0,04792264 0,06682364 ! collagen fibril organization GO:0030199 62 21 0,000 0,04792264 0,06678552 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,04792264 0,06674744 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,04792264 0,06670941 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,04792264 0,06667142 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,04792264 0,06663348 ! collagen catabolic process GO:0030574 29 21 0,000 0,04792264 0,06659557 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,04792264 0,06655771 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,04792264 0,0665199 ! sperm-egg recognition GO:0035036 23 21 0,000 0,04792264 0,06648212 ! actin filament-based movement GO:0030048 47 21 0,000 0,04792264 0,06644439 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,04792264 0,0664067 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,05014719 0,06944987 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,05014719 0,06941052 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,05014719 0,06937122 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,05014719 0,06933196 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,05014719 0,06929275 ! microtubule-based transport GO:0010970 59 22 0,000 0,05014719 0,06925358 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,05014719 0,06921445 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,05014719 0,06917537 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,05014719 0,06913633 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,05014719 0,06909733 ! cellular response to starvation GO:0009267 37 22 0,000 0,05014719 0,06905838 ! vacuolar transport GO:0007034 41 22 0,000 0,05014719 0,06901948 ! central nervous system neuron development GO:0021954 47 22 0,000 0,05014719 0,06898062 ! fucose metabolic process GO:0006004 44 22 0,000 0,05014719 0,0689418 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,05014719 0,06890302 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,05014719 0,06886429 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,05014719 0,0688256 ! ureteric bud development GO:0001657 50 22 0,000 0,05014719 0,06878696 ! cell aging GO:0007569 48 22 0,000 0,05014719 0,06874836 ! stem cell differentiation GO:0048863 57 22 0,000 0,05014719 0,0687098 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,05014719 0,06867129 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,05014719 0,06863282 ! cytolysis GO:0019835 27 22 0,000 0,05014719 0,06859439 ! renal system process GO:0003014 42 22 0,000 0,05014719 0,068556 ! vasodilation GO:0042311 40 22 0,000 0,05014719 0,06851766 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,05014719 0,06847936 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! G1 phase GO:0051318 44 22 0,000 0,05014719 0,0684411 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,05014719 0,06840289 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,05014719 0,06836472 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,05014719 0,06832659 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,05014719 0,0682885 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,05014719 0,06825046 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,05014719 0,06821246 ! sarcomere organization GO:0045214 32 22 0,000 0,05014719 0,0681745 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,05014719 0,06813658 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,05014719 0,06809871 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,05014719 0,06806087 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,05014719 0,06802308 ! gut development GO:0048565 44 22 0,000 0,05014719 0,06798534 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,05014719 0,06794763 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,05014719 0,06790996 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,05014719 0,06787234 ! protein stabilization GO:0050821 41 22 0,000 0,05014719 0,06783476 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,05236659 0,07079778 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,05236659 0,07075862 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,05236659 0,07071951 ! gluconeogenesis GO:0006094 38 23 0,000 0,05236659 0,07068043 ! glycerol metabolic process GO:0006071 40 23 0,000 0,05236659 0,07064141 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,05236659 0,07060242 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,05236659 0,07056348 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,05236659 0,07052458 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,05236659 0,07048572 ! regeneration GO:0031099 42 23 0,000 0,05236659 0,07044691 ! axis specification GO:0009798 43 23 0,000 0,05236659 0,07040814 ! visual behavior GO:0007632 46 23 0,000 0,05236659 0,07036941 ! regulation of cell-matrix adhesion GO:0001952 81 23 0,000 0,05236659 0,07033072 GO:0010810|regulation of cell-substrate adhesion, ! regulation of DNA recombination GO:0000018 51 23 0,000 0,05236659 0,07029208 ! response to ethanol GO:0045471 47 23 0,000 0,05236659 0,07025348 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,05236659 0,07021492 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,05236659 0,07017641 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,05236659 0,07013793 ! peroxisome organization GO:0007031 43 23 0,000 0,05236659 0,0700995 ! lysosome organization GO:0007040 47 23 0,000 0,05236659 0,07006111 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,05236659 0,07002276 ! vesicle targeting GO:0006903 49 23 0,000 0,05236659 0,06998446 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,05236659 0,06994619 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,05236659 0,06990797 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,05236659 0,06986979 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,05236659 0,06983165 ! DNA modification GO:0006304 36 23 0,000 0,05236659 0,06979356 ! fatty acid transport GO:0015908 47 23 0,000 0,05236659 0,0697555 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,05236659 0,06971749 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,05236659 0,06967951 ! hormone transport GO:0009914 41 23 0,000 0,05236659 0,06964158 ! cell-cell recognition GO:0009988 28 23 0,000 0,05236659 0,06960369 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,05236659 0,06956584 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,05236659 0,06952804 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,05236659 0,06949027 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,05458088 0,0723893 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,05458088 0,07235002 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,05458088 0,07231078 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,05458088 0,07227159 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,05458088 0,07223244 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,05458088 0,07219333 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,05458088 0,07215427 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,05458088 0,07211524 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,05458088 0,07207626 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,05458088 0,07203732 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,05458088 0,07199842 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,05458088 0,07195957 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,05458088 0,07192076 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,05458088 0,07188198 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,05458088 0,07184326 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,05458088 0,07180457 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,05458088 0,07176592 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,05458088 0,07172732 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,05458088 0,07168875 ! membrane depolarization GO:0051899 45 24 0,000 0,05458088 0,07165023 ! oogenesis GO:0048477 44 24 0,000 0,05458088 0,07161175 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,05458088 0,07157331 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,05458088 0,07153492 ! platelet activation GO:0030168 41 24 0,000 0,05458088 0,07149656 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,05458088 0,07145824 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,05458088 0,07141997 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,05458088 0,07138174 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,05458088 0,07134354 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,05458088 0,07130539 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,05458088 0,07126728 ! regulation of amine transport GO:0051952 41 24 0,000 0,05458088 0,07122921 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 0,000 0,05458088 0,07119118 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,05679005 0,07403313 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,05679005 0,07399365 ! leukocyte adhesion GO:0007159 55 25 0,000 0,05679005 0,07395421 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,05679005 0,0739148 ! keratinization GO:0031424 37 25 0,000 0,05679005 0,07387545 ! vasculogenesis GO:0001570 49 25 0,000 0,05679005 0,07383613 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 0,000 0,05679005 0,07379686 ! vacuole organization GO:0007033 49 25 0,000 0,05679005 0,07375762 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,05679005 0,07371843 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,05679005 0,07367928 ! receptor metabolic process GO:0043112 53 25 0,000 0,05679005 0,07364017 ! chromosome condensation GO:0030261 48 25 0,000 0,05679005 0,07360111 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,05679005 0,07356208 ! regulation of behavior GO:0050795 48 25 0,000 0,05679005 0,0735231 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,05679005 0,07348416 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,05679005 0,07344526 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,05679005 0,0734064 ! immunoglobulin production GO:0002377 62 25 0,000 0,05679005 0,07336758 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,05679005 0,0733288 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,05679005 0,07329006 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,05679005 0,07325137 ! liver development GO:0001889 55 25 0,000 0,05679005 0,07321271 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,05899412 0,07601405 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,05899412 0,07597398 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,05899412 0,07593395 ! molting cycle process GO:0022404 52 26 0,000 0,05899412 0,07589396 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,05899412 0,07585402 ! microtubule organizing center organization GO:0031023 42 26 0,000 0,05899412 0,07581412 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,05899412 0,07577426 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,05899412 0,07573444 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,05899412 0,07569466 ! digestive system process GO:0022600 49 26 0,000 0,05899412 0,07565493 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,05899412 0,07561523 ! osteoblast differentiation GO:0001649 63 26 0,000 0,05899412 0,07557558 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,05899412 0,07553597 ! neural crest cell development GO:0014032 59 26 0,000 0,05899412 0,0754964 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,05899412 0,07545688 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,05899412 0,07541739 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,05899412 0,07537795 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,05899412 0,07533854 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,05899412 0,07529918 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,05899412 0,07525986 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,05899412 0,07522058 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,05899412 0,07518134 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,05899412 0,07514215 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,05899412 0,07510299 ! blastocyst development GO:0001824 50 26 0,000 0,05899412 0,07506387 ! telomere organization GO:0032200 46 26 0,000 0,05899412 0,0750248 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,05899412 0,07498576 ! neural tube closure GO:0001843 58 26 0,000 0,05899412 0,07494677 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,05899412 0,07490782 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,05899412 0,0748689 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,05899412 0,07483003 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,0611931 0,07757901 ! embryonic pattern specification GO:0009880 49 27 0,000 0,0611931 0,07753877 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,0611931 0,07749858 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,0611931 0,07745842 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,0611931 0,07741831 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,0611931 0,07737824 ! iron ion transport GO:0006826 65 27 0,000 0,0611931 0,07733821 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,0611931 0,07729822 ! superoxide metabolic process GO:0006801 41 27 0,000 0,0611931 0,07725827 ! tube lumen formation GO:0035148 59 27 0,000 0,0611931 0,07721836 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,0611931 0,0771785 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,0611931 0,07713868 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,0611931 0,07709889 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,0611931 0,07705915 ! response to starvation GO:0042594 47 27 0,000 0,0611931 0,07701945 ! response to toxin GO:0009636 49 27 0,000 0,0611931 0,07697979 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,0611931 0,07694017 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,0611931 0,07690059 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,0611931 0,07686106 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,0611931 0,07682156 ! leukocyte proliferation GO:0070661 59 27 0,000 0,0611931 0,0767821 GO:0032943|mononuclear cell proliferation, ! neuron fate commitment GO:0048663 52 28 0,000 0,06338701 0,07949408 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,06338701 0,07945329 ! vesicle docking GO:0048278 55 28 0,000 0,06338701 0,07941255 ! circadian rhythm GO:0007623 56 28 0,000 0,06338701 0,07937184 ! dendrite development GO:0016358 67 28 0,000 0,06338701 0,07933118 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,06338701 0,07929056 ! fat cell differentiation GO:0045444 57 28 0,000 0,06338701 0,07924998 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,06338701 0,07920945 ! sperm motility GO:0030317 37 28 0,000 0,06338701 0,07916895 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,06338701 0,0791285 ! base-excision repair GO:0006284 41 28 0,000 0,06338701 0,07908808 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,06338701 0,07904771 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,06338701 0,07900738 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,06338701 0,07896709 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,06338701 0,07892684 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,06338701 0,07888664 ! glutathione metabolic process GO:0006749 42 28 0,000 0,06338701 0,07884647 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,06338701 0,07880634 ! lipid oxidation GO:0034440 48 28 0,000 0,06338701 0,07876626 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,06338701 0,07872622 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,06338701 0,07868621 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,06557585 0,08136201 ! translational initiation GO:0006413 66 29 0,000 0,06557585 0,08132071 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,06557585 0,08127945 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,06557585 0,08123824 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,06557585 0,08119706 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,06557585 0,08115593 ! autophagy GO:0006914 47 29 0,000 0,06557585 0,08111484 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,06557585 0,08107379 ! primary neural tube formation GO:0014020 61 29 0,000 0,06557585 0,08103278 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,06557585 0,08099181 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,06557585 0,08095089 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,06557585 0,08091 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 0,000 0,06557585 0,08086916 ! synaptogenesis GO:0007416 46 29 0,000 0,06557585 0,08082836 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,06557585 0,0807876 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,06557585 0,08074688 ! negative regulation of neuron apoptosis GO:0043524 69 29 0,000 0,06557585 0,0807062 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,06775964 0,08335186 ! phenol metabolic process GO:0018958 56 30 0,000 0,06775964 0,08330991 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,06775964 0,08326801 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,06775964 0,08322614 ! sensory perception of taste GO:0050909 41 30 0,000 0,06775964 0,08318432 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,06775964 0,08314254 ! acute-phase response GO:0006953 50 30 0,000 0,06775964 0,0831008 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,06775964 0,08305911 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,06775964 0,08301745 ! myofibril assembly GO:0030239 50 30 0,000 0,06775964 0,08297584 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 72 30 0,000 0,06775964 0,08293427 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,06775964 0,08289274 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,06775964 0,08285125 ! cell fate determination GO:0001709 64 30 0,000 0,06775964 0,0828098 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,06775964 0,0827684 ! phospholipid transport GO:0015914 65 30 0,000 0,06775964 0,08272703 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,06775964 0,08268571 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,06775964 0,08264443 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,06775964 0,08260319 GO:0043433|negative regulation of transcription factor activity, ! regulation of coagulation GO:0050818 52 30 0,000 0,06775964 0,08256199 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,06993838 0,08517421 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,06993838 0,08513177 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,06993838 0,08508938 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,06993838 0,08504702 ! cell junction assembly GO:0034329 85 31 0,000 0,06993838 0,08500471 ! regulation of innate immune response GO:0045088 57 31 0,000 0,06993838 0,08496244 ! ovulation cycle process GO:0022602 55 31 0,000 0,06993838 0,08492021 ! peptide transport GO:0015833 60 31 0,000 0,06993838 0,08487803 ! male gonad development GO:0008584 56 31 0,000 0,06993838 0,08483588 ! iron ion homeostasis GO:0055072 60 31 0,000 0,06993838 0,08479378 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,06993838 0,08475172 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 0,000 0,06993838 0,0847097 ! natural killer cell activation GO:0030101 50 31 0,000 0,06993838 0,08466773 ! cofactor catabolic process GO:0051187 54 31 0,000 0,06993838 0,08462579 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,06993838 0,0845839 ! eye morphogenesis GO:0048592 65 31 0,000 0,06993838 0,08454204 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,06993838 0,08450023 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,0721121 0,08708347 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,0721121 0,08704044 ! collagen metabolic process GO:0032963 49 32 0,000 0,0721121 0,08699746 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,0721121 0,08695452 ! spindle organization GO:0007051 50 32 0,000 0,0721121 0,08691162 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,0721121 0,08686876 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,0721121 0,08682595 ! metanephros development GO:0001656 81 32 0,000 0,0721121 0,08678318 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,0721121 0,08674045 ! muscle cell development GO:0055001 52 32 0,000 0,0721121 0,08669776 ! mesoderm formation GO:0001707 73 32 0,000 0,0721121 0,08665512 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,0721121 0,08661251 ! ovulation cycle GO:0042698 57 32 0,000 0,0721121 0,08656995 ! BMP signaling pathway GO:0030509 71 32 0,000 0,0721121 0,08652743 ! hindbrain development GO:0030902 65 32 0,000 0,0721121 0,08648496 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,0721121 0,08644252 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,0721121 0,08640012 ! gene silencing GO:0016458 71 32 0,000 0,0721121 0,08635777 ! regulation of pH GO:0006885 56 33 0,000 0,07428079 0,08891131 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,07428079 0,08886777 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,07428079 0,08882427 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,07428079 0,08878081 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,07428079 0,0887374 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,07428079 0,08869403 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,07428079 0,0886507 ! response to ionizing radiation GO:0010212 74 33 0,000 0,07428079 0,08860741 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,07428079 0,08856417 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,07428079 0,08852096 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,07428079 0,0884778 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,07428079 0,08843469 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,07428079 0,08839161 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,07428079 0,08834858 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,07644448 0,09087779 ! glial cell differentiation GO:0010001 67 34 0,000 0,07644448 0,09083359 ! post-embryonic development GO:0009791 76 34 0,000 0,07644448 0,09078943 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,07644448 0,09074532 ! cholesterol transport GO:0030301 62 34 0,000 0,07644448 0,09070125 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,07644448 0,09065722 ! spliceosome assembly GO:0000245 75 34 0,000 0,07644448 0,09061323 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,07644448 0,09056928 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,07644448 0,09052538 ! formation of primary germ layer GO:0001704 76 34 0,000 0,07644448 0,09048152 ! cell fate specification GO:0001708 56 34 0,000 0,07644448 0,09043771 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,07644448 0,09039393 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,07644448 0,0903502 ! adult locomotory behavior GO:0008344 62 34 0,000 0,07644448 0,09030651 ! DNA damage checkpoint GO:0000077 78 35 0,000 0,07860317 0,09281177 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,07860317 0,09276693 ! negative regulation of secretion GO:0051048 68 35 0,000 0,07860317 0,09272214 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,07860317 0,09267739 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,07860317 0,09263268 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,07860317 0,09258802 ! membrane docking GO:0022406 69 35 0,000 0,07860317 0,0925434 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,07860317 0,09249882 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,07860317 0,09245428 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,07860317 0,09240979 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,07860317 0,09236534 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,07860317 0,09232094 ! ceramide metabolic process GO:0006672 72 35 0,000 0,07860317 0,09227657 ! sterol transport GO:0015918 63 35 0,000 0,07860317 0,09223225 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,07860317 0,09218797 ! placenta development GO:0001890 53 35 0,000 0,07860317 0,09214374 ! vesicle localization GO:0051648 70 35 0,000 0,07860317 0,09209954 ! regulation of muscle development GO:0048634 82 36 0,000 0,08075688 0,09457768 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,08075688 0,09453237 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,08075688 0,09448709 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,08075688 0,09444186 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,08075688 0,09439667 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,08075688 0,09435153 ! positive regulation of cell development GO:0010720 85 36 0,000 0,08075688 0,09430643 ! protein targeting to membrane GO:0006612 75 36 0,000 0,08075688 0,09426137 ! regulation of proteolysis GO:0030162 77 36 0,000 0,08075688 0,09421636 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,08075688 0,09417138 ! aerobic respiration GO:0009060 56 36 0,000 0,08075688 0,09412645 ! cytokine production GO:0001816 68 36 0,000 0,08075688 0,09408157 ! embryonic organ development GO:0048568 67 36 0,000 0,08075688 0,09403672 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,08075688 0,09399192 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,08075688 0,09394717 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,08290561 0,09640095 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,08290561 0,09635509 ! negative regulation of cell adhesion GO:0007162 94 37 0,000 0,08290561 0,09630927 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,08290561 0,0962635 ! sister chromatid segregation GO:0000819 65 37 0,000 0,08290561 0,09621777 ! odontogenesis GO:0042476 74 37 0,000 0,08290561 0,09617208 ! actomyosin structure organization GO:0031032 68 37 0,000 0,08290561 0,09612644 ! cell junction organization GO:0034330 96 37 0,000 0,08290561 0,09608084 ! tissue remodeling GO:0048771 78 37 0,000 0,08290561 0,09603528 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,08290561 0,09598976 ! female gonad development GO:0008585 71 37 0,000 0,08290561 0,09594429 ! regulation of microtubule-based process GO:0032886 86 37 0,000 0,08290561 0,09589886 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,08504938 0,09833205 ! meiosis I GO:0007127 74 38 0,000 0,08504938 0,09828554 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,08504938 0,09823907 ! organic anion transport GO:0015711 82 38 0,000 0,08504938 0,09819264 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,08504938 0,09814626 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,08504938 0,09809992 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,08504938 0,09805362 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 0,000 0,08504938 0,09800737 ! regulation of protein stability GO:0031647 77 38 0,000 0,08504938 0,09796116 ! spermatid development GO:0007286 69 38 0,000 0,08504938 0,097915 ! glycogen metabolic process GO:0005977 63 38 0,000 0,08504938 0,09786888 ! pigment metabolic process GO:0042440 87 38 0,000 0,08504938 0,0978228 ! neural tube formation GO:0001841 79 38 0,000 0,08504938 0,09777677 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,0871882 0,10018851 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,0871882 0,1001414 ! negative regulation of binding GO:0051100 71 39 0,000 0,0871882 0,10009434 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,0871882 0,10004733 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,0871882 0,10000036 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,0871882 0,09995343 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,0871882 0,09990655 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,0871882 0,09985971 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,0871882 0,09981292 ! glucan metabolic process GO:0044042 64 39 0,000 0,0871882 0,09976617 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,08932208 0,10216003 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,08932208 0,10211223 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,08932208 0,10206447 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,08932208 0,10201675 ! lipid homeostasis GO:0055088 75 40 0,000 0,08932208 0,10196908 ! mismatch repair GO:0006298 58 40 0,000 0,08932208 0,10192145 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,08932208 0,10187387 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,08932208 0,10182633 ! RNA export from nucleus GO:0006405 61 41 0,000 0,09145103 0,10420469 ! mRNA catabolic process GO:0006402 79 41 0,000 0,09145103 0,10415611 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,09145103 0,10410758 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,09145103 0,10405909 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,09145103 0,10401064 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,09145103 0,10396224 ! gliogenesis GO:0042063 91 41 0,000 0,09145103 0,10391389 ! feeding behavior GO:0007631 69 41 0,000 0,09145103 0,10386558 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,09145103 0,10381731 ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,09145103 0,10376909 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,09145103 0,10372092 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,09145103 0,10367279 ! spermatid differentiation GO:0048515 73 41 0,000 0,09145103 0,1036247 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,09145103 0,10357666 ! RNA modification GO:0009451 64 41 0,000 0,09145103 0,10352866 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,09357506 0,10588415 ! ear morphogenesis GO:0042471 64 42 0,000 0,09357506 0,10583513 ! organic ether metabolic process GO:0018904 59 42 0,000 0,09357506 0,10578615 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,09357506 0,10573722 ! T cell differentiation GO:0030217 93 42 0,000 0,09357506 0,10568834 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,09357506 0,1056395 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,09357506 0,1055907 ! regulation of protein secretion GO:0050708 77 42 0,000 0,09357506 0,10554195 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,09357506 0,10549325 ! cytokinesis GO:0000910 84 42 0,000 0,09357506 0,10544459 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,09357506 0,10539598 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,09569419 0,10773313 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,09569419 0,10768351 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,09569419 0,10763393 ! regulation of tube size GO:0035150 76 43 0,000 0,09569419 0,1075844 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,09569419 0,10753491 ! glucose transport GO:0015758 66 43 0,000 0,09569419 0,10748547 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,09569419 0,10743608 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,09569419 0,10738673 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,09569419 0,10733742 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,09569419 0,10728816 ! ion transmembrane transport GO:0034220 79 43 0,000 0,09569419 0,10723895 ! neuron migration GO:0001764 85 43 0,000 0,09569419 0,10718978 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,09569419 0,10714065 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,09780842 0,10945761 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,09780842 0,1094075 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,09780842 0,10935742 ! negative regulation of protein complex disassembly GO:0043242 113 44 0,000 0,09780842 0,1093074 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,09780842 0,10925742 ! hexose transport GO:0008645 68 44 0,000 0,09780842 0,10920748 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,09780842 0,10915759 ! striated muscle contraction GO:0006941 85 44 0,000 0,09780842 0,10910775 ! phagocytosis GO:0006909 105 44 0,000 0,09780842 0,10905795 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,09780842 0,1090082 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,09991777 0,11130831 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,09991777 0,11125757 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,09991777 0,11120689 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,09991777 0,11115624 ! B cell differentiation GO:0030183 124 45 0,000 0,09991777 0,11110565 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,09991777 0,1110551 ! female gamete generation GO:0007292 71 45 0,000 0,09991777 0,1110046 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,09991777 0,11095414 ! polyol metabolic process GO:0019751 77 45 0,000 0,09991777 0,11090373 ! developmental growth GO:0048589 88 45 0,000 0,09991777 0,11085337 ! maintenance of location in cell GO:0051651 101 45 0,000 0,09991777 0,11080305 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,10202225 0,11308546 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,10202225 0,11303417 ! glycolysis GO:0006096 71 46 0,000 0,10202225 0,11298293 ! leukocyte migration GO:0050900 75 46 0,000 0,10202225 0,11293174 ! negative regulation of cell migration GO:0030336 122 46 0,000 0,10202225 0,11288059 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,10202225 0,11282949 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,10202225 0,11277844 ! pigmentation GO:0043473 103 46 0,000 0,10202225 0,11272743 ! cell growth GO:0016049 90 46 0,000 0,10202225 0,11267647 ! neural tube development GO:0021915 91 47 0,000 0,10412186 0,11494338 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,10412186 0,11489147 ! positive regulation of defense response GO:0031349 88 48 0,000 0,10621663 0,11714999 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,10621663 0,11709712 ! mitochondrial transport GO:0006839 94 48 0,000 0,10621663 0,1170443 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,10621663 0,11699153 ! cellular component disassembly GO:0022411 89 48 0,000 0,10621663 0,11693881 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,10621663 0,11688614 ! endosome transport GO:0016197 127 48 0,000 0,10621663 0,11683351 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,10621663 0,11678093 ! male sex differentiation GO:0046661 93 48 0,000 0,10621663 0,1167284 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,10621663 0,11667591 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,10621663 0,11662347 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,10621663 0,11657108 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,10621663 0,11651873 ! response to calcium ion GO:0051592 94 49 0,000 0,10830655 0,11875804 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,10830655 0,11870476 ! JNK cascade GO:0007254 106 49 0,000 0,10830655 0,11865153 ! regulation of ion transport GO:0043269 86 50 0,000 0,11039165 0,12088158 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,11039165 0,12082742 ! endocrine system development GO:0035270 109 50 0,000 0,11039165 0,12077331 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,11039165 0,12071925 ! activation of caspase activity GO:0006919 95 50 0,000 0,11039165 0,12066524 ! regulation of ossification GO:0030278 123 50 0,000 0,11039165 0,12061127 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,11039165 0,12055736 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,11039165 0,12050349 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,11039165 0,12044967 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,11039165 0,1203959 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,11039165 0,12034217 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,11247193 0,12255528 ! peptide metabolic process GO:0006518 80 51 0,000 0,11247193 0,12250064 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,11454741 0,12470558 ! Notch signaling pathway GO:0007219 111 52 0,000 0,11454741 0,12465003 ! regulation of protein complex disassembly GO:0043244 127 52 0,000 0,11454741 0,12459453 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,11454741 0,12453908 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,11454741 0,12448368 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,11454741 0,12442833 ! excretion GO:0007588 87 52 0,000 0,11454741 0,12437303 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,11454741 0,12431778 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,11454741 0,12426257 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,11454741 0,12420742 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,11454741 0,12415232 ! respiratory electron transport chain GO:0022904 83 53 0,000 0,11661809 0,12634057 ! inner ear development GO:0048839 89 53 0,000 0,11661809 0,12628457 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,11661809 0,12622862 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,11661809 0,12617271 ! vesicle organization GO:0016050 127 53 0,000 0,11661809 0,12611686 ! regulation of neuron apoptosis GO:0043523 117 53 0,000 0,11661809 0,12606106 ! cartilage development GO:0051216 99 53 0,000 0,11661809 0,1260053 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,11868398 0,1281808 ! neuromuscular process GO:0050905 107 54 0,000 0,11868398 0,12812416 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,11868398 0,12806757 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,11868398 0,12801103 ! membrane fusion GO:0006944 122 54 0,000 0,11868398 0,12795453 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,11868398 0,12789809 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,11868398 0,1278417 ! regulation of cell shape GO:0008360 142 54 0,000 0,11868398 0,12778536 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,11868398 0,12772906 ! RNA catabolic process GO:0006401 103 55 0,000 0,12074511 0,12989005 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,12074511 0,12983288 ! cell recognition GO:0008037 98 55 0,000 0,12074511 0,12977576 ! regulation of multicellular organism growth GO:0040014 90 55 0,000 0,12074511 0,12971869 ! cell maturation GO:0048469 107 55 0,000 0,12074511 0,12966167 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,12074511 0,1296047 ! negative regulation of cell motion GO:0051271 142 55 0,000 0,12074511 0,12954778 ! negative regulation of cytoskeleton organization GO:0051494 139 56 0,000 0,12280147 0,13169622 ! glucose catabolic process GO:0006007 88 56 0,000 0,12280147 0,13163843 ! RNA elongation GO:0006354 90 56 0,000 0,12280147 0,13158069 ! chloride transport GO:0006821 102 57 0,000 0,12485307 0,13372032 ! regulation of bone remodeling GO:0046850 143 57 0,000 0,12485307 0,13366173 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,12485307 0,13360318 GO:0010952|positive regulation of peptidase activity, ! nucleotide-excision repair GO:0006289 91 57 0,000 0,12485307 0,13354468 ! regulation of actin filament length GO:0030832 118 58 0,000 0,12689994 0,13567464 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,12689994 0,13561529 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,12689994 0,13555599 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,12689994 0,13549675 ! aging GO:0007568 112 58 0,000 0,12689994 0,13543755 ! gastrulation GO:0007369 122 58 0,000 0,12689994 0,13537841 ! regulation of tissue remodeling GO:0034103 146 58 0,000 0,12689994 0,13531932 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,12689994 0,13526028 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,12689994 0,13520129 ! maintenance of location GO:0051235 124 58 0,000 0,12689994 0,13514235 ! nuclear export GO:0051168 110 59 0,000 0,12894208 0,1372573 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,1309795 0,13936538 ! DNA catabolic process GO:0006308 94 60 0,000 0,1309795 0,13930471 ! regulation of endocytosis GO:0030100 104 60 0,000 0,1309795 0,13924409 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,1309795 0,13918352 ! adult behavior GO:0030534 104 60 0,000 0,1309795 0,13912301 ! kidney development GO:0001822 133 60 0,000 0,1309795 0,13906254 ! positive regulation of secretion GO:0051047 110 61 0,000 0,13301221 0,14115935 ! regulation of cellular component size GO:0032535 125 61 0,000 0,13301221 0,14109806 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,13301221 0,14103682 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,13301221 0,14097563 ! cytokine-mediated signaling pathway GO:0019221 112 61 0,000 0,13301221 0,1409145 ! regulation of heart contraction GO:0008016 123 61 0,000 0,13301221 0,14085341 ! camera-type eye development GO:0043010 126 61 0,000 0,13301221 0,14079239 ! proton transport GO:0015992 117 61 0,000 0,13301221 0,14073141 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,13301221 0,14067049 ! DNA damage response, signal transduction GO:0042770 136 62 0,000 0,13504022 0,14275347 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,13504022 0,14269172 ! regulation of homeostatic process GO:0032844 148 62 0,000 0,13504022 0,14263003 ! regulation of mitosis GO:0007088 112 63 0,000 0,13706355 0,14470452 GO:0051783|regulation of nuclear division, ! mesoderm development GO:0007498 128 63 0,000 0,13706355 0,14464201 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,13706355 0,14457955 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,13706355 0,14451716 ! hydrogen transport GO:0006818 121 64 0,000 0,1390822 0,14658232 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,1390822 0,14651911 ! integrin-mediated signaling pathway GO:0007229 160 64 0,000 0,1390822 0,14645595 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,14109618 0,1485127 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,14109618 0,14844874 ! multicellular organism reproduction GO:0032504 123 65 0,000 0,14109618 0,14838484 GO:0048609|reproductive process in a multicellular organism, ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,14109618 0,14832099 ! ear development GO:0043583 114 66 0,000 0,14310551 0,1503685 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,14310551 0,15030386 ! gonad development GO:0008406 115 66 0,000 0,14310551 0,15023926 ! chromosome segregation GO:0007059 127 67 0,000 0,1451102 0,15227844 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,1451102 0,15221306 ! secondary metabolic process GO:0019748 125 67 0,000 0,1451102 0,15214773 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,14711025 0,15417861 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,14711025 0,1541125 ! hexose catabolic process GO:0019320 113 68 0,000 0,14711025 0,15404644 ! extracellular matrix organization GO:0030198 146 68 0,000 0,14711025 0,15398044 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,14711025 0,15391449 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,14711025 0,15384861 ! adaptive immune response GO:0002250 126 68 0,000 0,14711025 0,15378277 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,14711025 0,153717 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,14910568 0,15573543 ! urogenital system development GO:0001655 149 69 0,000 0,14910568 0,15566888 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,14910568 0,15560238 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,14910568 0,15553594 ! developmental maturation GO:0021700 128 69 0,000 0,14910568 0,15546956 ! single fertilization GO:0007338 83 69 0,000 0,14910568 0,15540323 ! cell redox homeostasis GO:0045454 114 70 0,000 0,1510965 0,15741098 ! germ cell development GO:0007281 133 70 0,000 0,1510965 0,15734388 ! activation of immune response GO:0002253 120 70 0,000 0,1510965 0,15727684 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,1510965 0,15720986 ! cell cycle checkpoint GO:0000075 145 71 0,000 0,15308271 0,15920863 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,15308271 0,15914088 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,15308271 0,15907319 ! carbohydrate transport GO:0008643 114 72 0,000 0,15506434 0,16106385 ! actin filament organization GO:0007015 167 72 0,000 0,15506434 0,1609954 ! B cell activation GO:0042113 179 72 0,000 0,15506434 0,16092701 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,15506434 0,16085867 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,15506434 0,1607904 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,15506434 0,16072218 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,15506434 0,16065402 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,15506434 0,16058591 ! humoral immune response GO:0006959 115 73 0,000 0,15704138 0,16256444 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,15704138 0,16249559 ! regulation of immune effector process GO:0002697 156 73 0,000 0,15704138 0,16242679 ! acute inflammatory response GO:0002526 118 74 0,000 0,15901385 0,16439731 ! amino acid transport GO:0006865 148 74 0,000 0,15901385 0,16432777 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 0,000 0,15901385 0,16425828 ! transition metal ion transport GO:0000041 143 75 0,000 0,16098176 0,16622081 ! reproductive structure development GO:0048608 131 75 0,000 0,16098176 0,16615059 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,16098176 0,16608043 ! eye development GO:0001654 155 75 0,000 0,16098176 0,16601032 ! rhythmic process GO:0048511 142 75 0,000 0,16098176 0,16594027 ! cell-matrix adhesion GO:0007160 181 76 0,000 0,16294513 0,16789327 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,16294513 0,16782249 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,16294513 0,16775177 ! regulation of blood pressure GO:0008217 134 76 0,000 0,16294513 0,1676811 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,16294513 0,1676105 ! amine catabolic process GO:0009310 136 77 0,000 0,16490395 0,16955402 ! neurotransmitter transport GO:0006836 142 77 0,000 0,16490395 0,16948269 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,16490395 0,16941142 ! regulation of vesicle-mediated transport GO:0060627 136 77 0,000 0,16490395 0,16934021 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,16490395 0,16926905 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,16490395 0,16919796 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,16685824 0,17113127 ! antigen processing and presentation GO:0019882 117 78 0,000 0,16685824 0,17105946 ! fertilization GO:0009566 99 78 0,000 0,16685824 0,17098771 ! blood coagulation GO:0007596 151 79 0,000 0,16880802 0,17291321 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,16880802 0,17284074 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,16880802 0,17276833 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,16880802 0,17269598 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,16880802 0,17262369 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,17075329 0,17453987 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,17075329 0,17446687 ! negative regulation of organelle organization GO:0010639 181 80 0,000 0,17075329 0,17439393 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,17269406 0,17630238 ! cell-substrate adhesion GO:0031589 189 82 0,000 0,17463034 0,17820465 ! protein import into nucleus GO:0006606 174 82 0,000 0,17463034 0,17813024 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,17656215 0,18002559 ! exocytosis GO:0006887 153 83 0,000 0,17656215 0,17995049 ! response to drug GO:0042493 149 83 0,000 0,17656215 0,17987545 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,17656215 0,17980047 ! nuclear import GO:0051170 177 83 0,000 0,17656215 0,17972555 ! inorganic anion transport GO:0015698 156 83 0,000 0,17656215 0,1796507 ! response to metal ion GO:0010038 158 84 0,000 0,17848949 0,18153614 ! T cell activation GO:0042110 189 84 0,000 0,17848949 0,1814606 ! digestion GO:0007586 130 84 0,000 0,17848949 0,18138511 ! regulation of ligase activity GO:0051340 147 84 0,000 0,17848949 0,18130969 ! hemostasis GO:0007599 165 85 0,000 0,18041237 0,18318679 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,18041237 0,18311068 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,18041237 0,18303464 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,1823308 0,18490417 ! regulation of lyase activity GO:0051339 169 86 0,000 0,1823308 0,18482745 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,1842448 0,18669019 ! mitochondrion organization GO:0007005 159 87 0,000 0,1842448 0,18661279 ! alcohol catabolic process GO:0046164 142 87 0,000 0,1842448 0,18653545 ! cellular respiration GO:0045333 143 88 0,000 0,18615437 0,18839069 ! amine biosynthetic process GO:0009309 146 88 0,000 0,18615437 0,18831268 ! sensory perception of smell GO:0007608 117 88 0,000 0,18615437 0,18823474 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,18805953 0,19008251 ! tube morphogenesis GO:0035239 194 89 0,000 0,18805953 0,1900039 ! cellular defense response GO:0006968 123 89 0,000 0,18805953 0,18992535 ! protein localization in nucleus GO:0034504 192 89 0,000 0,18805953 0,18984687 ! regulation of neurological system process GO:0031644 175 89 0,000 0,18805953 0,18976845 ! response to inorganic substance GO:0010035 173 90 0,000 0,18996028 0,19160733 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,18996028 0,19152825 ! positive regulation of protein modification process GO:0031401 156 90 0,000 0,18996028 0,19144924 ! regulation of cell cycle process GO:0010564 161 90 0,000 0,18996028 0,19137029 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,19185663 0,19320105 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,19185663 0,19312144 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,19563619 0,19684481 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,19563619 0,19676377 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,19563619 0,1966828 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,19751941 0,19849441 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,19751941 0,1984128 ! regulation of defense response GO:0031347 171 95 0,000 0,19939828 0,20021784 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,19939828 0,20013558 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,19939828 0,20005339 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,19939828 0,19997126 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,19939828 0,19988921 ! sex differentiation GO:0007548 171 96 0,000 0,2012728 0,20168558 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,20314299 0,20347615 ! transcription initiation GO:0006352 171 97 0,000 0,20314299 0,20339275 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,20500885 0,20517682 ! mRNA transport GO:0051028 185 100 0,000 0,20872763 0,2088131 ! positive regulation of immune response GO:0050778 175 100 0,000 0,20872763 0,20872763