pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6389-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! branching morphogenesis of a tube GO:0048754 72 42 6,000 4,887E-09 1,124E-05 ! tube morphogenesis GO:0035239 118 73 7,000 1,166E-08 1,341E-05 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 4,000 1,297E-08 9,946E-06 GO:0060675|ureteric bud morphogenesis, ! morphogenesis of a branching structure GO:0001763 86 49 6,000 1,504E-08 8,649E-06 ! induction of positive chemotaxis GO:0050930 14 8 3,000 8,123E-08 3,736E-05 ! ureteric bud development GO:0001657 32 22 4,000 1,643E-07 6,299E-05 ! epithelial tube morphogenesis GO:0060562 65 43 5,000 1,954E-07 6,421E-05 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 3,777E-07 1,086E-04 GO:0050927|positive regulation of positive chemotaxis, ! cartilage development GO:0051216 70 49 5,000 4,355E-07 1,113E-04 ! regulation of bone remodeling GO:0046850 90 53 5,000 7,014E-07 1,613E-04 ! regulation of tissue remodeling GO:0034103 91 54 5,000 7,853E-07 1,642E-04 ! metanephros development GO:0001656 58 31 4,000 1,016E-06 1,948E-04 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 1,13E-06 1,999E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 2,028E-06 3,331E-04 ! neutrophil chemotaxis GO:0030593 21 16 3,000 2,036E-06 3,122E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 4,000 3,316E-06 4,766E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 3,392E-06 4,589E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 3,771E-06 4,819E-04 ! ER overload response GO:0006983 7 6 2,000 4,038E-06 4,888E-04 ! positive regulation of ossification GO:0045778 30 19 3,000 4,277E-06 4,918E-04 ! positive regulation of locomotion GO:0040017 35 20 3,000 5,321E-06 5,828E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! gland development GO:0048732 148 77 5,000 6,455E-06 6,748E-04 ! positive regulation of bone remodeling GO:0046852 33 21 3,000 6,543E-06 6,543E-04 GO:0034105|positive regulation of tissue remodeling, ! regulation of chemotaxis GO:0050920 36 21 3,000 6,543E-06 6,271E-04 ! cell aging GO:0007569 32 21 3,000 6,543E-06 6,02E-04 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 2,000 7,036E-06 6,224E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 7,036E-06 5,993E-04 ! B cell lineage commitment GO:0002326 17 7 2,000 7,036E-06 5,779E-04 ! T cell lineage commitment GO:0002360 12 7 2,000 7,036E-06 5,58E-04 ! regulation of ossification GO:0030278 71 46 4,000 7,637E-06 5,855E-04 ! protein import into nucleus, translocation GO:0000060 36 22 3,000 7,961E-06 5,907E-04 ! regulation of behavior GO:0050795 38 22 3,000 7,961E-06 5,722E-04 ! regulation of neuron apoptosis GO:0043523 77 47 4,000 8,506E-06 5,929E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,121E-05 7,582E-04 ! positive regulation of cell migration GO:0030335 92 51 4,000 1,278E-05 8,4E-04 ! skeletal system morphogenesis GO:0048705 78 53 4,000 1,547E-05 9,884E-04 ! kidney development GO:0001822 90 53 4,000 1,547E-05 9,616E-04 ! lung alveolus development GO:0048286 17 9 2,000 1,674E-05 1,013E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 1,674E-05 9,872E-04 ! positive regulation of cell motion GO:0051272 99 56 4,000 2,03E-05 1,167E-03 ! angiogenesis GO:0001525 149 95 5,000 2,17E-05 1,218E-03 ! hair follicle morphogenesis GO:0031069 17 10 2,000 2,381E-05 1,304E-03 ! cell-matrix adhesion GO:0007160 114 61 4,000 3,088E-05 1,652E-03 ! urogenital system development GO:0001655 101 61 4,000 3,088E-05 1,614E-03 ! focal adhesion formation GO:0048041 24 11 2,000 3,26E-05 1,666E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 3,26E-05 1,63E-03 ! digestive tract morphogenesis GO:0048546 15 11 2,000 3,26E-05 1,595E-03 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of glucose import GO:0046325 14 11 2,000 3,26E-05 1,562E-03 GO:0010829|negative regulation of glucose transport, ! mammary gland development GO:0030879 57 31 3,000 3,286E-05 1,543E-03 ! leukocyte chemotaxis GO:0030595 43 31 3,000 3,286E-05 1,512E-03 GO:0060326|cell chemotaxis, ! positive regulation of cell development GO:0010720 54 33 3,000 4,235E-05 1,91E-03 ! gland morphogenesis GO:0022612 23 12 2,000 4,327E-05 1,914E-03 ! response to gamma radiation GO:0010332 20 12 2,000 4,327E-05 1,878E-03 ! cell-substrate adhesion GO:0031589 121 66 4,000 4,532E-05 1,93E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 5,601E-05 2,342E-03 ! positive regulation of bone mineralization GO:0030501 19 13 2,000 5,601E-05 2,301E-03 ! response to drug GO:0042493 108 69 4,000 5,619E-05 2,267E-03 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 7,098E-05 2,815E-03 ! epidermis morphogenesis GO:0048730 29 14 2,000 7,098E-05 2,767E-03 ! cellular response to starvation GO:0009267 21 14 2,000 7,098E-05 2,721E-03 ! positive regulation of biomineral formation GO:0070169 20 14 2,000 7,098E-05 2,676E-03 ! epithelial to mesenchymal transition GO:0001837 22 14 2,000 7,098E-05 2,633E-03 ! mesenchymal cell development GO:0014031 64 38 3,000 7,467E-05 2,726E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! protein import into nucleus GO:0006606 118 74 4,000 7,867E-05 2,827E-03 ! negative regulation of growth GO:0045926 123 75 4,000 8,389E-05 2,968E-03 ! nuclear import GO:0051170 121 75 4,000 8,389E-05 2,923E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 8,834E-05 3,033E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 8,834E-05 2,988E-03 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 8,834E-05 2,945E-03 ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 8,834E-05 2,903E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 9,161E-05 2,968E-03 ! patterning of blood vessels GO:0001569 24 16 2,000 1,083E-04 3,458E-03 ! complement activation, alternative pathway GO:0006957 16 16 2,000 1,083E-04 3,411E-03 ! protein localization in nucleus GO:0034504 133 80 4,000 1,141E-04 3,547E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 1,22E-04 3,742E-03 ! leukocyte migration GO:0050900 60 43 3,000 1,22E-04 3,693E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 1,309E-04 3,91E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 1,309E-04 3,86E-03 ! cell-substrate junction assembly GO:0007044 39 17 2,000 1,309E-04 3,811E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 1,309E-04 3,763E-03 ! proximal/distal pattern formation GO:0009954 25 17 2,000 1,309E-04 3,717E-03 ! negative regulation of homeostatic process GO:0032845 28 17 2,000 1,309E-04 3,671E-03 ! negative regulation of multicellular organismal process GO:0051241 133 85 4,000 1,521E-04 4,215E-03 ! cellular response to nutrient levels GO:0031669 27 18 2,000 1,564E-04 4,282E-03 ! regulation of glucose import GO:0046324 21 18 2,000 1,564E-04 4,232E-03 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 2,000 1,564E-04 4,183E-03 ! response to UV GO:0009411 75 46 3,000 1,592E-04 4,208E-03 ! protein processing GO:0016485 114 88 4,000 1,791E-04 4,682E-03 ! response to alkaloid GO:0043279 32 19 2,000 1,849E-04 4,779E-03 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 2,000 1,849E-04 4,726E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,849E-04 4,674E-03 ! response to starvation GO:0042594 30 19 2,000 1,849E-04 4,623E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 1,849E-04 4,573E-03 ! regulation of neurogenesis GO:0050767 153 89 4,000 1,889E-04 4,622E-03 ! collagen fibril organization GO:0030199 45 20 2,000 2,166E-04 5,244E-03 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 2,166E-04 5,19E-03 ! positive regulation of osteoblast differentiation GO:0045669 33 20 2,000 2,166E-04 5,136E-03 ! cell fate commitment GO:0045165 141 92 4,000 2,207E-04 5,179E-03 ! dendrite development GO:0016358 35 21 2,000 2,516E-04 5,846E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 2,516E-04 5,787E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 2,516E-04 5,73E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 2,516E-04 5,674E-03 ! regulation of bone mineralization GO:0030500 29 21 2,000 2,516E-04 5,619E-03 ! aging GO:0007568 79 52 3,000 2,569E-04 5,682E-03 ! protein maturation GO:0051604 129 96 4,000 2,692E-04 5,897E-03 ! response to light stimulus GO:0009416 153 96 4,000 2,692E-04 5,841E-03 ! molting cycle process GO:0022404 40 22 2,000 2,901E-04 6,236E-03 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! odontogenesis of dentine-containing tooth GO:0042475 37 22 2,000 2,901E-04 6,178E-03 ! extracellular structure organization GO:0043062 156 99 4,000 3,106E-04 6,554E-03 ! protein import GO:0017038 156 99 4,000 3,106E-04 6,494E-03 ! protein localization in organelle GO:0033365 161 100 4,000 3,254E-04 6,743E-03 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 3,322E-04 6,821E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 3,322E-04 6,761E-03 ! regulation of biomineral formation GO:0070167 31 23 2,000 3,322E-04 6,702E-03 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 3,322E-04 6,643E-03 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 3,423E-04 6,786E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,464E-04 6,811E-03 ! forebrain regionalization GO:0021871 6 5 1,000 3,464E-04 6,753E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 3,464E-04 6,696E-03 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 3,464E-04 6,64E-03 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 3,464E-04 6,585E-03 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 3,464E-04 6,531E-03 ! negative regulation of multicellular organism growth GO:0040015 7 5 1,000 3,464E-04 6,478E-03 ! muscle cell proliferation GO:0033002 8 5 1,000 3,464E-04 6,426E-03 ! regulation of hair follicle development GO:0051797 9 5 1,000 3,464E-04 6,375E-03 GO:0042634|regulation of hair cycle, ! glial cell migration GO:0008347 10 5 1,000 3,464E-04 6,324E-03 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 3,464E-04 6,274E-03 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 3,464E-04 6,225E-03 GO:0007439|ectodermal gut development, ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 3,464E-04 6,177E-03 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 3,464E-04 6,129E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 3,664E-04 6,434E-03 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 3,664E-04 6,385E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 3,78E-04 6,537E-03 ! mitochondrial membrane organization GO:0007006 39 24 2,000 3,78E-04 6,488E-03 ! negative regulation of cell development GO:0010721 56 24 2,000 3,78E-04 6,44E-03 GO:0050768|negative regulation of neurogenesis, ! regulation of osteoblast differentiation GO:0045667 37 24 2,000 3,78E-04 6,392E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 3,918E-04 6,577E-03 ! lung development GO:0030324 94 59 3,000 4,184E-04 6,973E-03 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 4,277E-04 7,077E-03 GO:0045936|negative regulation of phosphate metabolic process, ! embryonic limb morphogenesis GO:0030326 86 60 3,000 4,462E-04 7,331E-03 GO:0035113|embryonic appendage morphogenesis, ! regulation of heart contraction GO:0008016 91 60 3,000 4,462E-04 7,279E-03 ! regulation of homeostatic process GO:0032844 105 60 3,000 4,462E-04 7,228E-03 ! extracellular matrix organization GO:0030198 103 61 3,000 4,754E-04 7,646E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 4,754E-04 7,593E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 4,814E-04 7,636E-03 ! negative regulation of cell growth GO:0030308 106 62 3,000 5,058E-04 7,969E-03 ! respiratory tube development GO:0030323 99 62 3,000 5,058E-04 7,915E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 5,177E-04 8,045E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 5,177E-04 7,991E-03 ! mRNA stabilization GO:0048255 15 6 1,000 5,177E-04 7,937E-03 GO:0043489|RNA stabilization, ! spinal cord dorsal/ventral patterning GO:0021513 6 6 1,000 5,177E-04 7,885E-03 ! activation of MAPKKK activity GO:0000185 10 6 1,000 5,177E-04 7,833E-03 ! pigment granule organization GO:0048753 11 6 1,000 5,177E-04 7,782E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 5,177E-04 7,731E-03 ! interaction with symbiont GO:0051702 8 6 1,000 5,177E-04 7,681E-03 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 5,177E-04 7,632E-03 ! salivary gland morphogenesis GO:0007435 11 6 1,000 5,177E-04 7,583E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 5,177E-04 7,535E-03 ! axonal fasciculation GO:0007413 9 6 1,000 5,177E-04 7,488E-03 ! negative regulation of axon extension GO:0030517 13 6 1,000 5,177E-04 7,441E-03 ! regulation of Rac protein signal transduction GO:0035020 8 6 1,000 5,177E-04 7,395E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 5,177E-04 7,349E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 5,377E-04 7,587E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 5,392E-04 7,562E-03 ! negative regulation of neuron apoptosis GO:0043524 42 27 2,000 5,392E-04 7,516E-03 ! negative regulation of cell size GO:0045792 108 64 3,000 5,709E-04 7,911E-03 ! appendage morphogenesis GO:0035107 93 64 3,000 5,709E-04 7,863E-03 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 3,000 5,709E-04 7,816E-03 ! cell junction assembly GO:0034329 56 28 2,000 6,013E-04 8,184E-03 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 6,013E-04 8,135E-03 ! BMP signaling pathway GO:0030509 40 28 2,000 6,013E-04 8,088E-03 ! appendage development GO:0048736 94 65 3,000 6,056E-04 8,098E-03 GO:0060173|limb development, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 7,219E-04 9,597E-03 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 7,219E-04 9,542E-03 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 7,219E-04 9,488E-03 ! microtubule bundle formation GO:0001578 8 7 1,000 7,219E-04 9,434E-03 ! T-helper 1 type immune response GO:0042088 11 7 1,000 7,219E-04 9,381E-03 ! spinal cord patterning GO:0021511 7 7 1,000 7,219E-04 9,328E-03 ! regulation of pigmentation during development GO:0048070 15 7 1,000 7,219E-04 9,276E-03 ! organ growth GO:0035265 11 7 1,000 7,219E-04 9,224E-03 ! behavioral fear response GO:0001662 13 7 1,000 7,219E-04 9,173E-03 GO:0002209|behavioral defense response, ! response to UV-B GO:0010224 11 7 1,000 7,219E-04 9,123E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 7,219E-04 9,073E-03 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 1,000 7,219E-04 9,024E-03 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 7,219E-04 8,975E-03 ! response to tumor cell GO:0002347 12 7 1,000 7,219E-04 8,927E-03 ! peptidyl-threonine modification GO:0018210 18 7 1,000 7,219E-04 8,879E-03 ! positive regulation of epidermis development GO:0045684 11 7 1,000 7,219E-04 8,832E-03 ! dopamine biosynthetic process GO:0042416 15 7 1,000 7,219E-04 8,785E-03 ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 7,219E-04 8,739E-03 ! embryonic skeletal system morphogenesis GO:0048704 42 30 2,000 7,388E-04 8,897E-03 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 8,017E-04 9,604E-03 ! humoral immune response GO:0006959 86 70 3,000 8,017E-04 9,554E-03 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 8,017E-04 9,505E-03 ! DNA damage checkpoint GO:0000077 53 31 2,000 8,144E-04 9,606E-03 ! odontogenesis GO:0042476 50 31 2,000 8,144E-04 9,557E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 8,915E-04 0,01040782 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 3,000 8,915E-04 0,01035525 ! mitochondrion organization GO:0007005 104 73 3,000 9,389E-04 0,01085112 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 1,000 9,588E-04 0,01102615 GO:0046579|positive regulation of Ras protein signal transduction, ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 9,588E-04 0,01097129 ! smoothened signaling pathway GO:0007224 8 8 1,000 9,588E-04 0,01091698 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 9,588E-04 0,0108632 ! keratinocyte proliferation GO:0043616 12 8 1,000 9,588E-04 0,01080995 ! middle ear morphogenesis GO:0042474 9 8 1,000 9,588E-04 0,01075722 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 9,588E-04 0,010705 ! melanin metabolic process GO:0006582 12 8 1,000 9,588E-04 0,01065328 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 9,588E-04 0,01060206 ! regulation of vascular permeability GO:0043114 12 8 1,000 9,588E-04 0,01055134 ! regulation of smoothened signaling pathway GO:0008589 13 8 1,000 9,588E-04 0,01050109 ! regulation of gliogenesis GO:0014013 20 8 1,000 9,588E-04 0,01045132 GO:0045685|regulation of glial cell differentiation, ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 9,588E-04 0,01040203 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 9,588E-04 0,01035319 ! regulation of telomere maintenance GO:0032204 10 8 1,000 9,588E-04 0,01030481 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 1,000 9,588E-04 0,01025688 ! mitochondrion localization GO:0051646 12 8 1,000 9,588E-04 0,0102094 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 9,588E-04 0,01016235 ! cell junction organization GO:0034330 63 33 2,000 9,801E-04 0,01034033 ! negative regulation of hydrolase activity GO:0051346 50 33 2,000 9,801E-04 0,01029312 ! response to oxygen levels GO:0070482 137 74 3,000 9,88E-04 0,01032922 ! response to nutrient GO:0007584 104 75 3,000 1,039E-03 0,01081258 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 1,07E-03 0,01108877 ! DNA integrity checkpoint GO:0031570 57 34 2,000 1,07E-03 0,01103904 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 1,07E-03 0,01098976 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,07E-03 0,01094092 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 2,000 1,07E-03 0,01089251 ! regulation of cell morphogenesis GO:0022604 140 76 3,000 1,092E-03 0,0110613 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 1,166E-03 0,01175839 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 1,228E-03 0,01233316 ! protein complex disassembly GO:0043241 17 9 1,000 1,228E-03 0,01227954 GO:0043624|cellular protein complex disassembly, ! ventral spinal cord development GO:0021517 11 9 1,000 1,228E-03 0,01222638 ! T cell selection GO:0045058 18 9 1,000 1,228E-03 0,01217368 ! motor axon guidance GO:0008045 14 9 1,000 1,228E-03 0,01212144 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,228E-03 0,01206964 ! oocyte differentiation GO:0009994 12 9 1,000 1,228E-03 0,01201828 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 1,228E-03 0,01196735 ! spleen development GO:0048536 15 9 1,000 1,228E-03 0,01191686 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 1,228E-03 0,01186678 ! response to nicotine GO:0035094 16 9 1,000 1,228E-03 0,01181713 ! localization within membrane GO:0051668 15 9 1,000 1,228E-03 0,01176789 ! response to reactive oxygen species GO:0000302 55 36 2,000 1,266E-03 0,01208323 ! neural tube development GO:0021915 50 36 2,000 1,266E-03 0,0120333 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 2,000 1,372E-03 0,01298512 GO:0006956|complement activation, ! response to protein stimulus GO:0051789 111 81 3,000 1,384E-03 0,01304548 ! pigmentation GO:0043473 74 38 2,000 1,483E-03 0,01392296 ! regulation of cell adhesion GO:0030155 159 83 3,000 1,515E-03 0,01416275 ! neuron fate specification GO:0048665 11 10 1,000 1,529E-03 0,01423756 ! negative regulation of blood pressure GO:0045776 22 10 1,000 1,529E-03 0,01418015 ! regulation of phosphatase activity GO:0010921 21 10 1,000 1,529E-03 0,0141232 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 1,529E-03 0,01406671 ! blood vessel remodeling GO:0001974 21 10 1,000 1,529E-03 0,01401067 ! positive regulation of heart contraction GO:0045823 14 10 1,000 1,529E-03 0,01395507 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,529E-03 0,01389991 ! response to X-ray GO:0010165 16 10 1,000 1,529E-03 0,01384519 ! B cell proliferation GO:0042100 14 10 1,000 1,529E-03 0,01379089 ! fear response GO:0042596 16 10 1,000 1,529E-03 0,01373702 ! negative regulation of ossification GO:0030279 19 10 1,000 1,529E-03 0,01368357 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,529E-03 0,01363053 ! regulation of bone resorption GO:0045124 24 10 1,000 1,529E-03 0,01357791 ! alpha-beta T cell activation GO:0046631 16 10 1,000 1,529E-03 0,01352568 ! negative regulation of axonogenesis GO:0050771 23 10 1,000 1,529E-03 0,01347386 ! cranial nerve development GO:0021545 12 10 1,000 1,529E-03 0,01342243 ! DNA methylation GO:0006306 15 10 1,000 1,529E-03 0,0133714 GO:0006305|DNA alkylation, ! salivary gland development GO:0007431 22 10 1,000 1,529E-03 0,01332075 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,529E-03 0,01327048 ! embryonic gut development GO:0048566 11 10 1,000 1,529E-03 0,01322059 ! cardiac cell differentiation GO:0035051 16 10 1,000 1,529E-03 0,01317108 ! developmental growth GO:0048589 62 39 2,000 1,6E-03 0,01372952 ! regulation of protein localization GO:0032880 132 85 3,000 1,654E-03 0,01414222 ! T cell differentiation GO:0030217 65 40 2,000 1,722E-03 0,01466951 ! B cell differentiation GO:0030183 62 40 2,000 1,722E-03 0,01461537 ! positive regulation of protein transport GO:0051222 55 40 2,000 1,722E-03 0,01456164 ! cell cycle arrest GO:0007050 150 86 3,000 1,727E-03 0,0145487 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 1,727E-03 0,0144956 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,862E-03 0,01556909 ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,862E-03 0,01551268 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 1,862E-03 0,01545668 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 1,862E-03 0,01540108 ! mitotic spindle organization GO:0007052 15 11 1,000 1,862E-03 0,01534588 ! regulation of intracellular pH GO:0051453 17 11 1,000 1,862E-03 0,01529107 ! T cell homeostasis GO:0043029 20 11 1,000 1,862E-03 0,01523666 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,862E-03 0,01518263 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 1,862E-03 0,01512898 GO:0042130|negative regulation of T cell proliferation, ! interphase GO:0051325 159 88 3,000 1,879E-03 0,01521875 ! mitochondrial transport GO:0006839 60 42 2,000 1,984E-03 0,01600967 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 1,984E-03 0,01595369 ! cellular component disassembly GO:0022411 64 42 2,000 1,984E-03 0,01589811 ! embryonic skeletal system development GO:0048706 56 42 2,000 1,984E-03 0,0158429 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 2,123E-03 0,01689936 ! activation of caspase activity GO:0006919 65 43 2,000 2,123E-03 0,01684108 ! response to insulin stimulus GO:0032868 63 43 2,000 2,123E-03 0,01678321 ! positive regulation of immune response GO:0050778 121 92 3,000 2,211E-03 0,01741776 ! negative regulation of cell projection organization GO:0031345 26 12 1,000 2,225E-03 0,01746722 ! cartilage condensation GO:0001502 18 12 1,000 2,225E-03 0,0174078 ! positive regulation of cell growth GO:0030307 16 12 1,000 2,225E-03 0,0173488 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 2,225E-03 0,01729018 ! regulation of epidermis development GO:0045682 17 12 1,000 2,225E-03 0,01723197 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,225E-03 0,01717414 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,225E-03 0,0171167 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 2,269E-03 0,01739596 ! regulation of inflammatory response GO:0050727 60 44 2,000 2,269E-03 0,01733816 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,421E-03 0,01843568 ! positive regulation of defense response GO:0031349 59 45 2,000 2,421E-03 0,01837484 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 2,421E-03 0,01831439 ! regulation of response to external stimulus GO:0032101 139 96 3,000 2,582E-03 0,01946973 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 2,62E-03 0,01968953 ! exocrine system development GO:0035272 27 13 1,000 2,62E-03 0,0196254 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 2,62E-03 0,01956168 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 2,62E-03 0,01949837 ! regulation of cellular pH GO:0030641 20 13 1,000 2,62E-03 0,01943547 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 2,62E-03 0,01937298 ! cellular pigmentation GO:0033059 24 13 1,000 2,62E-03 0,01931089 ! regulation of RNA stability GO:0043487 28 13 1,000 2,62E-03 0,01924919 ! regulation of axon extension GO:0030516 23 13 1,000 2,62E-03 0,01918789 ! lymphocyte homeostasis GO:0002260 24 13 1,000 2,62E-03 0,01912697 ! response to estrogen stimulus GO:0043627 74 47 2,000 2,742E-03 0,01996097 ! negative regulation of immune system process GO:0002683 73 47 2,000 2,742E-03 0,019898 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 2,886E-03 0,02087567 ! positive regulation of caspase activity GO:0043280 72 48 2,000 2,913E-03 0,02100107 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 2,913E-03 0,02093544 ! heart morphogenesis GO:0003007 65 48 2,000 2,913E-03 0,02087022 ! Ras protein signal transduction GO:0007265 162 100 3,000 2,993E-03 0,02137851 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 3,044E-03 0,02167787 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 3,044E-03 0,02161097 ! activation of MAPKK activity GO:0000186 21 14 1,000 3,044E-03 0,02154447 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 3,044E-03 0,02147838 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 3,044E-03 0,0214127 ! G1/S transition checkpoint GO:0031575 33 14 1,000 3,044E-03 0,02134742 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 3,044E-03 0,02128253 ! catecholamine biosynthetic process GO:0042423 23 14 1,000 3,044E-03 0,02121804 ! cell killing GO:0001906 20 14 1,000 3,044E-03 0,02115394 ! regulation of intracellular transport GO:0032386 78 49 2,000 3,089E-03 0,02140265 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 3,089E-03 0,02133837 ! ear development GO:0043583 72 50 2,000 3,273E-03 0,02253549 ! positive regulation of growth GO:0045927 67 50 2,000 3,273E-03 0,02246822 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 3,273E-03 0,02240135 ! positive regulation of cell size GO:0045793 20 15 1,000 3,499E-03 0,02388106 ! metencephalon development GO:0022037 19 15 1,000 3,499E-03 0,0238104 ! lipid phosphorylation GO:0046834 23 15 1,000 3,499E-03 0,02374017 ! bile acid metabolic process GO:0008206 22 15 1,000 3,499E-03 0,02367034 ! regulation of survival gene product expression GO:0045884 20 15 1,000 3,499E-03 0,02360093 ! neuron recognition GO:0008038 22 15 1,000 3,499E-03 0,02353192 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 3,499E-03 0,02346331 ! dopamine metabolic process GO:0042417 30 15 1,000 3,499E-03 0,02339511 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 3,499E-03 0,02332729 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 3,499E-03 0,02325987 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 1,000 3,499E-03 0,02319284 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 3,499E-03 0,0231262 ! regulation of protein binding GO:0043393 27 16 1,000 3,983E-03 0,02625228 ! regulation of dephosphorylation GO:0035303 33 16 1,000 3,983E-03 0,02617728 ! negative regulation of immune response GO:0050777 28 16 1,000 3,983E-03 0,0261027 ! oogenesis GO:0048477 23 16 1,000 3,983E-03 0,02602854 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 3,983E-03 0,02595481 ! nerve development GO:0021675 18 16 1,000 3,983E-03 0,02588149 ! regulation of viral genome replication GO:0045069 24 17 1,000 4,497E-03 0,02913666 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 4,497E-03 0,02905481 ! cellular macromolecular complex disassembly GO:0034623 29 17 1,000 4,497E-03 0,02897342 ! actin filament bundle formation GO:0051017 26 17 1,000 4,497E-03 0,02889249 ! neuromuscular junction development GO:0007528 23 17 1,000 4,497E-03 0,02881201 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 4,511E-03 0,02881859 ! protein maturation by peptide bond cleavage GO:0051605 76 58 2,000 4,978E-03 0,03171708 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 5,04E-03 0,03202069 ! visual learning GO:0008542 35 18 1,000 5,04E-03 0,03193248 ! negative regulation of T cell activation GO:0050868 25 18 1,000 5,04E-03 0,03184475 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 5,04E-03 0,0317575 ! actin filament organization GO:0007015 95 59 2,000 5,222E-03 0,03281886 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 5,611E-03 0,03516392 ! regeneration GO:0031099 32 19 1,000 5,611E-03 0,03506836 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 5,611E-03 0,03497333 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 5,611E-03 0,0348788 ! apoptotic nuclear changes GO:0030262 24 19 1,000 5,611E-03 0,03478479 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 5,611E-03 0,03469128 ! renal system process GO:0003014 35 19 1,000 5,611E-03 0,03459828 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 5,611E-03 0,03450577 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 5,611E-03 0,03441375 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 5,611E-03 0,03432223 ! spinal cord development GO:0021510 31 20 1,000 6,21E-03 0,03788782 ! response to ethanol GO:0045471 37 20 1,000 6,21E-03 0,03778759 ! multicellular organismal response to stress GO:0033555 32 20 1,000 6,21E-03 0,03768789 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 6,21E-03 0,03758871 ! DNA modification GO:0006304 28 20 1,000 6,21E-03 0,03749005 ! collagen catabolic process GO:0030574 25 20 1,000 6,21E-03 0,03739191 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 6,21E-03 0,03729428 ! cell cycle checkpoint GO:0000075 108 64 2,000 6,552E-03 0,0392409 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 6,552E-03 0,03913897 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 6,838E-03 0,04074181 ! visual behavior GO:0007632 39 21 1,000 6,838E-03 0,04063653 ! ovarian follicle development GO:0001541 30 21 1,000 6,838E-03 0,0405318 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 6,838E-03 0,04042761 ! regulation of vasoconstriction GO:0019229 31 21 1,000 6,838E-03 0,04032394 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 6,838E-03 0,04022081 ! response to cytokine stimulus GO:0034097 47 21 1,000 6,838E-03 0,04011821 ! regulation of caspase activity GO:0043281 97 65 2,000 6,839E-03 0,04002602 ! B cell activation GO:0042113 104 65 2,000 6,839E-03 0,03992443 ! activation of immune response GO:0002253 83 65 2,000 6,839E-03 0,03982336 ! axon guidance GO:0007411 99 66 2,000 7,134E-03 0,04143686 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 7,437E-03 0,04308544 ! regulation of neuron differentiation GO:0045664 107 67 2,000 7,437E-03 0,04297718 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 7,492E-03 0,0431886 ! macromolecular complex disassembly GO:0032984 38 22 1,000 7,492E-03 0,04308063 ! vasculogenesis GO:0001570 33 22 1,000 7,492E-03 0,0429732 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 7,492E-03 0,0428663 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 7,492E-03 0,04275993 ! leukocyte homeostasis GO:0001776 33 22 1,000 7,492E-03 0,04265409 ! protein tetramerization GO:0051262 39 22 1,000 7,492E-03 0,04254877 ! acute inflammatory response GO:0002526 92 68 2,000 7,747E-03 0,04388693 ! activation of protein kinase activity GO:0032147 102 69 2,000 8,065E-03 0,045574 ! neuron fate commitment GO:0048663 32 23 1,000 8,174E-03 0,04608004 ! myelination GO:0042552 35 23 1,000 8,174E-03 0,04596738 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 8,174E-03 0,04585526 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 8,174E-03 0,04574369 ! negative regulation of DNA replication GO:0008156 35 23 1,000 8,174E-03 0,04563267 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 8,174E-03 0,04552217 ! regulation of viral reproduction GO:0050792 32 23 1,000 8,174E-03 0,04541222 ! interaction with host GO:0051701 37 23 1,000 8,174E-03 0,04530279 ! lymphocyte proliferation GO:0046651 36 23 1,000 8,174E-03 0,04519389 ! cellular response to oxidative stress GO:0034599 33 23 1,000 8,174E-03 0,04508551 ! eye development GO:0001654 111 70 2,000 8,39E-03 0,04616408 ! lymphocyte differentiation GO:0030098 113 71 2,000 8,723E-03 0,04788088 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 8,883E-03 0,04864471 ! response to toxin GO:0009636 38 24 1,000 8,883E-03 0,04852916 ! base-excision repair GO:0006284 31 24 1,000 8,883E-03 0,04841416 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 8,883E-03 0,04829971 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 8,883E-03 0,04818579 ! regulation of peptidase activity GO:0052547 106 72 2,000 9,063E-03 0,04904754 ! negative regulation of transport GO:0051051 116 73 2,000 9,411E-03 0,05081227 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 9,411E-03 0,05069327 ! male gonad development GO:0008584 33 25 1,000 9,618E-03 0,05168652 ! iron ion homeostasis GO:0055072 39 25 1,000 9,618E-03 0,05156604 ! regulation of chromosome organization GO:0033044 35 25 1,000 9,618E-03 0,05144612 ! response to estradiol stimulus GO:0032355 34 25 1,000 9,618E-03 0,05132676 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 9,618E-03 0,05120794 ! leukocyte proliferation GO:0070661 39 25 1,000 9,618E-03 0,05108968 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 9,618E-03 0,05097196 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 9,767E-03 0,05164283 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01037959 0,05475471 ! regulation of pH GO:0006885 36 26 1,000 0,01037959 0,05462942 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01037959 0,05450469 ! post-embryonic development GO:0009791 42 26 1,000 0,01037959 0,05438053 ! multicellular organismal catabolic process GO:0044243 32 26 1,000 0,01037959 0,05425694 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01037959 0,05413391 ! response to unfolded protein GO:0006986 99 76 2,000 0,01050238 0,05465041 ! regulation of protein transport GO:0051223 114 76 2,000 0,01050238 0,05452705 GO:0070201|regulation of establishment of protein localization, ! catechol metabolic process GO:0009712 43 27 1,000 0,01116682 0,05784614 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01116682 0,05771615 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,01126884 0,05811285 ! T cell activation GO:0042110 134 79 2,000 0,01166388 0,06001547 ! phenol metabolic process GO:0018958 44 28 1,000 0,01197955 0,06150216 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,01197955 0,06136518 GO:0055092|sterol homeostasis, ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01197955 0,06122881 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,01197955 0,06109305 ! mesoderm formation GO:0001707 46 28 1,000 0,01197955 0,06095789 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01197955 0,06082333 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01197955 0,06068935 GO:0008366|axon ensheathment, ! neural tube formation GO:0001841 41 28 1,000 0,01197955 0,06055597 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,01281746 0,06464946 ! ovulation cycle process GO:0022602 41 29 1,000 0,01281746 0,06450799 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,01281746 0,06436715 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01281746 0,06422691 ! formation of primary germ layer GO:0001704 48 29 1,000 0,01281746 0,06408729 ! telencephalon development GO:0021537 52 29 1,000 0,01281746 0,06394827 ! eye morphogenesis GO:0048592 51 29 1,000 0,01281746 0,06380985 ! tissue homeostasis GO:0001894 42 29 1,000 0,01281746 0,06367204 GO:0048871|multicellular organismal homeostasis, ! ossification GO:0001503 134 82 2,000 0,01289654 0,06392681 GO:0060348|bone development, ! collagen metabolic process GO:0032963 40 30 1,000 0,01368022 0,06766559 ! spindle organization GO:0007051 37 30 1,000 0,01368022 0,06752039 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,01368022 0,06737581 ! ovulation cycle GO:0042698 43 30 1,000 0,01368022 0,06723184 ! hindbrain development GO:0030902 45 30 1,000 0,01368022 0,06708849 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,01368022 0,06694575 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01368022 0,06680361 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01368022 0,06666208 ! response to heat GO:0009408 41 30 1,000 0,01368022 0,06652114 ! regulation of defense response GO:0031347 117 84 2,000 0,01375817 0,06675905 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01375817 0,0666185 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 0,014201 0,06861829 ! rRNA metabolic process GO:0016072 107 85 2,000 0,014201 0,06847444 GO:0006364|rRNA processing, ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 0,014201 0,06833119 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,014201 0,06818853 ! regulation of membrane potential GO:0042391 128 85 2,000 0,014201 0,06804647 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,01456751 0,06965754 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,01456751 0,06951303 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,01456751 0,06936911 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01456751 0,06922578 ! cell fate specification GO:0001708 37 31 1,000 0,01456751 0,06908305 ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 0,01456751 0,0689409 ! regulation of muscle development GO:0048634 48 32 1,000 0,01547902 0,07310422 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,01547902 0,07295442 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,01547902 0,07280523 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,01547902 0,07265664 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01547902 0,07250867 ! regulation of protein stability GO:0031647 48 32 1,000 0,01547902 0,07236129 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01547902 0,07221451 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01547902 0,07206833 ! ear morphogenesis GO:0042471 42 33 1,000 0,01641444 0,07626911 ! nucleus organization GO:0006997 49 33 1,000 0,01641444 0,07611535 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,01641444 0,0759622 ! female gonad development GO:0008585 49 33 1,000 0,01641444 0,07580966 ! lipid homeostasis GO:0055088 55 33 1,000 0,01641444 0,07565774 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01641444 0,07550642 ! leukocyte differentiation GO:0002521 143 90 2,000 0,01653607 0,07591409 ! response to virus GO:0009615 122 91 2,000 0,01702736 0,07801382 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,01737345 0,07944121 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,01737345 0,07928359 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,01737345 0,0791266 ! female gamete generation GO:0007292 43 34 1,000 0,01737345 0,07897022 ! embryonic organ development GO:0048568 45 34 1,000 0,01737345 0,07881446 ! peptidyl-amino acid modification GO:0018193 147 93 2,000 0,01803433 0,08165151 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,01835574 0,08294343 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01835574 0,08278079 ! pigment metabolic process GO:0042440 61 35 1,000 0,01835574 0,0826188 ! response to oxidative stress GO:0006979 141 94 2,000 0,01855003 0,0833302 ! tissue remodeling GO:0048771 62 36 1,000 0,01936101 0,08680376 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,01936101 0,08663488 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,01936101 0,08646666 GO:0006073|cellular glucan metabolic process, ! learning GO:0007612 67 37 1,000 0,02038896 0,09088103 ! amino acid activation GO:0043038 52 37 1,000 0,02038896 0,09070525 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! gliogenesis GO:0042063 71 38 1,000 0,02143929 0,09519375 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02143929 0,09501033 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,02143929 0,09482762 ! maintenance of location in cell GO:0051651 69 38 1,000 0,02143929 0,09464561 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,02251169 0,09918945 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,02251169 0,0989998 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,02251169 0,09881087 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,02251169 0,09862266 ! male sex differentiation GO:0046661 53 39 1,000 0,02251169 0,09843516 ! cell growth GO:0016049 61 39 1,000 0,02251169 0,09824838 ! synapse organization GO:0050808 55 39 1,000 0,02251169 0,0980623 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,02360588 0,10263428 ! double-strand break repair GO:0006302 67 40 1,000 0,02360588 0,10244063 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,02360588 0,10224771 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,02472157 0,10687896 ! glucose transport GO:0015758 52 41 1,000 0,02472157 0,10667844 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,02472157 0,10647866 ! biopolymer methylation GO:0043414 62 41 1,000 0,02472157 0,10627964 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,02585846 0,11095979 ! hexose transport GO:0008645 54 42 1,000 0,02585846 0,11075316 GO:0015749|monosaccharide transport, ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,02585846 0,1105473 ! regulation of cell shape GO:0008360 78 42 1,000 0,02585846 0,11034221 ! vesicle organization GO:0016050 79 43 1,000 0,02701626 0,11506926 ! methylation GO:0032259 64 43 1,000 0,02701626 0,11485656 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,0281947 0,11964541 ! regulation of action potential GO:0001508 71 44 1,000 0,0281947 0,11942507 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,0281947 0,11920554 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,0281947 0,11898681 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,0281947 0,11876889 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,02939349 0,12359238 ! cell recognition GO:0008037 58 45 1,000 0,02939349 0,12336685 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,0293964 0,12315432 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,0293964 0,1229304 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,0293964 0,12270729 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,0293964 0,122485 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,0293964 0,12226351 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,0293964 0,12204281 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,0293964 0,12182292 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,0293964 0,12160381 ! sleep GO:0030431 11 5 0,000 0,0293964 0,12138549 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,0293964 0,12116796 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,0293964 0,1209512 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,0293964 0,12073521 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,0293964 0,12052 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 6 5 0,000 0,0293964 0,12030555 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,0293964 0,12009186 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,0293964 0,11987893 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,0293964 0,11966676 ! cobalt ion transport GO:0006824 9 5 0,000 0,0293964 0,11945533 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,0293964 0,11924465 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,0293964 0,11903472 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,0293964 0,11882552 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,0293964 0,11861705 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,0293964 0,11840932 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,0293964 0,11820231 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,0293964 0,11799602 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,0293964 0,11779045 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,0293964 0,1175856 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,0293964 0,11738146 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,0293964 0,11717802 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,0293964 0,11697529 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,0293964 0,11677326 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,0293964 0,11657193 ! malate metabolic process GO:0006108 7 5 0,000 0,0293964 0,11637129 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,0293964 0,11617134 ! behavioral response to pain GO:0048266 7 5 0,000 0,0293964 0,11597207 ! clathrin coat assembly GO:0048268 11 5 0,000 0,0293964 0,11577349 ! phototransduction, visible light GO:0007603 6 5 0,000 0,0293964 0,11557559 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,0293964 0,11537836 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,0293964 0,1151818 ! mating behavior GO:0007617 6 5 0,000 0,0293964 0,11498592 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,0293964 0,11479069 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,0293964 0,11459613 ! rhythmic behavior GO:0007622 12 5 0,000 0,0293964 0,11440223 ! copulation GO:0007620 7 5 0,000 0,0293964 0,11420898 ! glial cell fate commitment GO:0021781 12 5 0,000 0,0293964 0,11401639 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,0293964 0,11382444 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,0293964 0,11363314 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,0293964 0,11344248 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,0293964 0,11325246 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,0293964 0,11306308 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,0293964 0,11287432 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,0293964 0,1126862 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,0293964 0,1124987 ! response to protozoan GO:0001562 9 5 0,000 0,0293964 0,11231183 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,0293964 0,11212557 ! lymph vessel development GO:0001945 7 5 0,000 0,0293964 0,11193993 ! endochondral ossification GO:0001958 12 5 0,000 0,0293964 0,11175491 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,0293964 0,11157049 ! parathyroid gland development GO:0060017 8 5 0,000 0,0293964 0,11138669 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,0293964 0,11120349 ! anagen GO:0042640 6 5 0,000 0,0293964 0,11102089 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,0293964 0,11083888 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,0293964 0,11065748 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,0293964 0,11047667 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,0293964 0,11029644 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,0293964 0,11011681 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,0293964 0,10993775 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,0293964 0,10975928 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,0293964 0,10958139 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,0293964 0,10940408 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,0293964 0,10922733 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,0293964 0,10905116 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,0293964 0,10887555 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,0293964 0,10870051 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,0293964 0,10852603 ! ovulation GO:0030728 6 5 0,000 0,0293964 0,10835211 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,0293964 0,10817875 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,0293964 0,10800594 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,0293964 0,10783368 ! response to pH GO:0009268 9 5 0,000 0,0293964 0,10766197 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,0293964 0,10749081 ! proline biosynthetic process GO:0006561 6 5 0,000 0,0293964 0,10732019 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,0293964 0,10715011 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,0293964 0,10698057 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,0293964 0,10681156 ! polyol catabolic process GO:0046174 7 5 0,000 0,0293964 0,10664309 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,0293964 0,10647515 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,0293964 0,10630773 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,0293964 0,10614085 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,0293964 0,10597448 ! nerve growth factor processing GO:0032455 7 5 0,000 0,0293964 0,10580864 ! urea metabolic process GO:0019627 6 5 0,000 0,0293964 0,10564331 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,0293964 0,1054785 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,0293964 0,1053142 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,0293964 0,10515042 ! neutrophil activation GO:0042119 5 5 0,000 0,0293964 0,10498714 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,0293964 0,10482437 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,0293964 0,1046621 ! response to food GO:0032094 5 5 0,000 0,0293964 0,10450034 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,0293964 0,10433907 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,0293964 0,1041783 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,0293964 0,10401803 ! forebrain neuron development GO:0021884 7 5 0,000 0,0293964 0,10385825 ! melanosome organization GO:0032438 7 5 0,000 0,0293964 0,10369896 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,0293964 0,10354015 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,0293964 0,10338183 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,0293964 0,103224 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,0293964 0,10306664 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,0293964 0,10290977 ! nucleoside transport GO:0015858 6 5 0,000 0,0293964 0,10275337 ! nucleoside salvage GO:0043174 7 5 0,000 0,0293964 0,10259745 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,0293964 0,102442 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,0293964 0,10228702 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,0293964 0,10213251 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,0293964 0,10197846 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,0293964 0,10182488 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,0293964 0,10167176 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,0293964 0,1015191 ! depyrimidination GO:0045008 8 5 0,000 0,0293964 0,1013669 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,0293964 0,10121515 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,0293964 0,10106386 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,0293964 0,10091301 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,0293964 0,10076262 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,0293964 0,10061268 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,0293964 0,10046318 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,0293964 0,10031412 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,0293964 0,10016551 ! monocyte differentiation GO:0030224 8 5 0,000 0,0293964 0,10001734 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,0293964 0,0998696 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,0293964 0,0997223 ! centrosome duplication GO:0051298 5 5 0,000 0,0293964 0,09957543 ! response to UV-C GO:0010225 6 5 0,000 0,0293964 0,099429 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,0293964 0,09928299 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,0293964 0,09913742 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,0293964 0,09899227 ! regulation of dendrite development GO:0050773 12 5 0,000 0,0293964 0,09884754 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,0293964 0,09870324 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,0293964 0,09855936 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,0293964 0,09841589 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,0293964 0,09827285 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,0293964 0,09813022 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,0293964 0,097988 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,0293964 0,09784619 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,0293964 0,0977048 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,0293964 0,09756381 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,0293964 0,09742323 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,0293964 0,09728305 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,0293964 0,09714327 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,0293964 0,0970039 ! neural tube patterning GO:0021532 6 5 0,000 0,0293964 0,09686493 ! histone demethylation GO:0016577 9 5 0,000 0,0293964 0,09672635 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,0293964 0,09658817 ! regulation of sterol transport GO:0032371 7 5 0,000 0,0293964 0,09645038 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,0293964 0,09631299 ! enteric nervous system development GO:0048484 8 5 0,000 0,0293964 0,09617599 ! establishment of planar polarity GO:0001736 6 5 0,000 0,0293964 0,09603937 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,0293964 0,09590315 ! transcription termination GO:0006353 8 5 0,000 0,0293964 0,09576731 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,0293964 0,09563185 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,0293964 0,09549678 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,0293964 0,09536209 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,0293964 0,09522777 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,0293964 0,09509384 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,0293964 0,09496028 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,0293964 0,0948271 GO:0015991|ATP hydrolysis coupled proton transport, ! protein destabilization GO:0031648 6 5 0,000 0,0293964 0,09469428 ! apical protein localization GO:0045176 6 5 0,000 0,0293964 0,09456184 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,0293964 0,09442978 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,0293964 0,09429807 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,0293964 0,09416674 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,0293964 0,09403577 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,0293964 0,09390517 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,0293964 0,09377492 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,0293964 0,09364504 ! determination of adult lifespan GO:0008340 8 5 0,000 0,0293964 0,09351552 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,0293964 0,09338635 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,0293964 0,09325754 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,0293964 0,09312909 ! neural plate development GO:0001840 6 5 0,000 0,0293964 0,09300099 ! regulation of sensory perception GO:0051931 6 5 0,000 0,0293964 0,09287324 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,0293964 0,09274584 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,0293964 0,09261879 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,0293964 0,09249209 ! sensory cilium assembly GO:0035058 6 5 0,000 0,0293964 0,09236574 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,0293964 0,09223973 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,0293964 0,09211406 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,0293964 0,09198873 ! spindle assembly GO:0051225 5 5 0,000 0,0293964 0,09186375 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,0293964 0,0917391 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,0293964 0,0916148 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,0293964 0,09149082 ! organ regeneration GO:0031100 7 5 0,000 0,0293964 0,09136719 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,0293964 0,09124389 ! carnitine metabolic process GO:0009437 5 5 0,000 0,0293964 0,09112092 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,0293964 0,09099828 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,0293964 0,09087597 GO:0055081|anion homeostasis, ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,03061236 0,09450795 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,03185102 0,09820019 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! response to temperature stimulus GO:0009266 62 48 1,000 0,0331092 0,10194266 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,0331092 0,10180638 ! gastrulation GO:0007369 73 48 1,000 0,0331092 0,10167045 ! regulation of DNA replication GO:0006275 75 48 1,000 0,0331092 0,10153489 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,0331092 0,10139969 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,03438664 0,10517191 ! germ cell development GO:0007281 68 49 1,000 0,03438664 0,10503224 ! maintenance of location GO:0051235 84 49 1,000 0,03438664 0,10489294 ! tRNA transcription GO:0009304 11 6 0,000 0,03517215 0,10714694 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03517215 0,10700522 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03517215 0,10686386 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03517215 0,10672288 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03517215 0,10658227 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03517215 0,10644203 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03517215 0,10630216 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03517215 0,10616265 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03517215 0,10602352 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03517215 0,10588474 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03517215 0,10574633 ! prostate gland development GO:0030850 9 6 0,000 0,03517215 0,10560828 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03517215 0,10547059 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03517215 0,10533326 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03517215 0,10519628 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03517215 0,10505967 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03517215 0,1049234 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03517215 0,10478749 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03517215 0,10465193 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03517215 0,10451672 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03517215 0,10438186 ! neuron adhesion GO:0007158 9 6 0,000 0,03517215 0,10424735 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,03517215 0,10411318 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03517215 0,10397936 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03517215 0,10384588 ! signal peptide processing GO:0006465 8 6 0,000 0,03517215 0,10371275 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03517215 0,10357995 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03517215 0,1034475 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03517215 0,10331538 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03517215 0,1031836 ! opsonization GO:0008228 8 6 0,000 0,03517215 0,10305216 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03517215 0,10292105 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03517215 0,10279027 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03517215 0,10265983 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03517215 0,10252971 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03517215 0,10239993 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03517215 0,10227047 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03517215 0,10214134 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03517215 0,10201254 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03517215 0,10188406 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03517215 0,1017559 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03517215 0,10162807 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03517215 0,10150056 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03517215 0,10137336 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03517215 0,10124649 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03517215 0,10111993 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03517215 0,10099369 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03517215 0,10086776 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03517215 0,10074215 ! thymic T cell selection GO:0045061 12 6 0,000 0,03517215 0,10061684 ! protein lipoylation GO:0009249 10 6 0,000 0,03517215 0,10049185 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03517215 0,10036717 ! drug transport GO:0015893 6 6 0,000 0,03517215 0,1002428 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03517215 0,10011874 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03517215 0,09999499 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03517215 0,09987153 ! histidine metabolic process GO:0006547 6 6 0,000 0,03517215 0,09974839 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03517215 0,09962555 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03517215 0,099503 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03517215 0,09938077 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03517215 0,09925883 ! adenohypophysis development GO:0021984 10 6 0,000 0,03517215 0,09913719 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03517215 0,09901584 ! hyperosmotic response GO:0006972 8 6 0,000 0,03517215 0,0988948 ! microtubule nucleation GO:0007020 10 6 0,000 0,03517215 0,09877405 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03517215 0,09865359 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03517215 0,09853343 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03517215 0,09841356 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03517215 0,09829398 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03517215 0,09817469 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03517215 0,09805569 ! response to dietary excess GO:0002021 7 6 0,000 0,03517215 0,09793698 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03517215 0,09781855 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03517215 0,09770041 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03517215 0,09758256 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03517215 0,09746499 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03517215 0,09734771 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03517215 0,0972307 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03517215 0,09711398 ! neuron apoptosis GO:0051402 8 6 0,000 0,03517215 0,09699753 ! organic alcohol transport GO:0015850 9 6 0,000 0,03517215 0,09688137 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03517215 0,09676548 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03517215 0,09664987 ! male sex determination GO:0030238 9 6 0,000 0,03517215 0,09653454 ! carnitine transport GO:0015879 8 6 0,000 0,03517215 0,09641948 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03517215 0,09630469 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03517215 0,09619018 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03517215 0,09607594 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03517215 0,09596197 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03517215 0,09584827 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03517215 0,09573484 ! parturition GO:0007567 12 6 0,000 0,03517215 0,09562168 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03517215 0,09550879 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03517215 0,09539616 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03517215 0,0952838 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03517215 0,0951717 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03517215 0,09505986 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03517215 0,09494829 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03517215 0,09483698 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03517215 0,09472593 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03517215 0,09461514 ! macrophage differentiation GO:0030225 10 6 0,000 0,03517215 0,09450461 ! astrocyte development GO:0014002 14 6 0,000 0,03517215 0,09439433 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03517215 0,09428432 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03517215 0,09417456 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03517215 0,09406505 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03517215 0,0939558 ! eating behavior GO:0042755 6 6 0,000 0,03517215 0,0938468 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03517215 0,09373806 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03517215 0,09362956 ! response to copper ion GO:0046688 9 6 0,000 0,03517215 0,09352132 ! DNA topological change GO:0006265 8 6 0,000 0,03517215 0,09341333 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03517215 0,09330559 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,03517215 0,09319809 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03517215 0,09309084 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03517215 0,09298384 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03517215 0,09287709 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03517215 0,09277058 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03517215 0,09266431 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03517215 0,09255829 ! gas homeostasis GO:0033483 11 6 0,000 0,03517215 0,09245251 ! hair follicle maturation GO:0048820 7 6 0,000 0,03517215 0,09234697 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03517215 0,09224167 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03517215 0,09213661 ! Schwann cell development GO:0014044 14 6 0,000 0,03517215 0,09203179 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03517215 0,09192721 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03517215 0,09182286 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03517215 0,09171876 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03517215 0,09161488 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03517215 0,09151125 ! histone ubiquitination GO:0016574 7 6 0,000 0,03517215 0,09140785 ! regulation of meiosis GO:0040020 10 6 0,000 0,03517215 0,09130468 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03517215 0,09120174 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03517215 0,09109903 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03517215 0,09099656 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03517215 0,09089432 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03517215 0,0907923 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03517215 0,09069052 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03517215 0,09058896 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03517215 0,09048763 ! receptor internalization GO:0031623 9 6 0,000 0,03517215 0,09038653 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03517215 0,09028565 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03517215 0,090185 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03517215 0,09008457 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 8 6 0,000 0,03517215 0,08998436 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03517215 0,08988438 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03517215 0,08978462 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03517215 0,08968508 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03517215 0,08958576 ! midbrain development GO:0030901 6 6 0,000 0,03517215 0,08948666 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03517215 0,08938778 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03517215 0,08928912 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03517215 0,08919068 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03517215 0,08909245 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03517215 0,08899444 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03517215 0,08889664 GO:0046479|glycosphingolipid catabolic process, ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03517215 0,08879906 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03517215 0,08870169 ! adult feeding behavior GO:0008343 6 6 0,000 0,03517215 0,08860454 ! blastocyst growth GO:0001832 15 6 0,000 0,03517215 0,0885076 ! pigment granule transport GO:0051904 12 6 0,000 0,03517215 0,08841087 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03517215 0,08831435 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03517215 0,08821804 ! catecholamine transport GO:0051937 7 6 0,000 0,03517215 0,08812194 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03517215 0,08802605 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03517215 0,08793037 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03517215 0,0878349 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03517215 0,08773963 ! protein prenylation GO:0018342 10 6 0,000 0,03517215 0,08764458 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03517215 0,08754972 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03517215 0,08745507 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03517215 0,08736063 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03517215 0,08726639 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,03568306 0,08843862 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,03568306 0,08834343 ! lipid modification GO:0030258 73 50 1,000 0,03568306 0,08824843 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,03568306 0,08815365 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 0,0369982 0,09130457 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,0369982 0,09120671 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,0369982 0,09110906 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,0369982 0,09101162 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03833179 0,09419137 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,03833179 0,09409084 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04091386 0,10032183 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04091386 0,10021499 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04091386 0,10010837 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04091386 0,10000199 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04091386 0,09989583 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04091386 0,0997899 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04091386 0,09968419 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04091386 0,0995787 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04091386 0,09947344 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04091386 0,0993684 ! reproductive behavior GO:0019098 12 7 0,000 0,04091386 0,09926358 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04091386 0,09915898 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,04091386 0,0990546 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04091386 0,09895044 ! oligopeptide transport GO:0006857 11 7 0,000 0,04091386 0,0988465 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04091386 0,09874278 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04091386 0,09863928 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04091386 0,09853599 ! RNA methylation GO:0001510 11 7 0,000 0,04091386 0,09843292 ! pericardium development GO:0060039 8 7 0,000 0,04091386 0,09833007 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04091386 0,09822742 ! fibril organization GO:0043206 13 7 0,000 0,04091386 0,098125 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04091386 0,09802278 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04091386 0,09792078 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04091386 0,09781899 ! lipoprotein transport GO:0042953 9 7 0,000 0,04091386 0,09771742 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04091386 0,09761605 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04091386 0,09751489 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04091386 0,09741395 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04091386 0,09731321 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04091386 0,09721268 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04091386 0,09711236 ! chemosensory behavior GO:0007635 9 7 0,000 0,04091386 0,09701224 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04091386 0,09691233 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04091386 0,09681263 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04091386 0,09671313 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04091386 0,09661383 ! reflex GO:0060004 12 7 0,000 0,04091386 0,09651474 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04091386 0,09641585 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04091386 0,09631717 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04091386 0,09621868 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04091386 0,0961204 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04091386 0,09602232 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04091386 0,09592444 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04091386 0,09582675 ! adrenal gland development GO:0030325 17 7 0,000 0,04091386 0,09572927 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04091386 0,09563198 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04091386 0,0955349 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04091386 0,095438 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04091386 0,09534131 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04091386 0,09524481 ! endosome organization GO:0007032 10 7 0,000 0,04091386 0,09514851 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04091386 0,0950524 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04091386 0,09495648 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04091386 0,09486076 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04091386 0,09476523 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04091386 0,09466989 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04091386 0,09457475 ! galactose metabolic process GO:0006012 10 7 0,000 0,04091386 0,09447979 ! vesicle fusion GO:0006906 15 7 0,000 0,04091386 0,09438503 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04091386 0,09429045 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04091386 0,09419607 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04091386 0,09410187 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04091386 0,09400786 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04091386 0,09391404 ! retinol metabolic process GO:0042572 9 7 0,000 0,04091386 0,09382041 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04091386 0,09372696 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04091386 0,0936337 ! rRNA modification GO:0000154 12 7 0,000 0,04091386 0,09354063 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04091386 0,09344774 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04091386 0,09335503 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04091386 0,09326251 ! intermediate filament organization GO:0045109 11 7 0,000 0,04091386 0,09317017 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04091386 0,09307801 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04091386 0,09298604 ! fibrinolysis GO:0042730 9 7 0,000 0,04091386 0,09289425 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04091386 0,09280264 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04091386 0,0927112 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04091386 0,09261995 ! response to tropane GO:0014073 13 7 0,000 0,04091386 0,09252888 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04091386 0,09243799 ! melanosome localization GO:0032400 10 7 0,000 0,04091386 0,09234727 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04091386 0,09225674 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04091386 0,09216638 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04091386 0,0920762 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04091386 0,09198619 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04091386 0,09189636 ! mast cell activation GO:0045576 9 7 0,000 0,04091386 0,0918067 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04091386 0,09171722 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04091386 0,09162792 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04091386 0,09153879 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04091386 0,09144983 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04091386 0,09136104 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04091386 0,09127243 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04091386 0,09118398 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04091386 0,09109571 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04091386 0,09100761 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04091386 0,09091968 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04091386 0,09083192 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04091386 0,09074433 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04091386 0,09065691 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04091386 0,09056966 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04091386 0,09048257 ! diuresis GO:0030146 12 7 0,000 0,04091386 0,09039565 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04091386 0,0903089 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04091386 0,09022231 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04091386 0,09013589 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04091386 0,09004964 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04091386 0,08996355 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04091386 0,08987762 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04091386 0,08979186 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04091386 0,08970627 ! lymph node development GO:0048535 9 7 0,000 0,04091386 0,08962083 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04091386 0,08953556 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04091386 0,08945045 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04091386 0,0893655 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04091386 0,08928071 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04091386 0,08919609 ! ATP catabolic process GO:0006200 10 7 0,000 0,04091386 0,08911162 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04091386 0,08902732 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04091386 0,08894317 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04091386 0,08885918 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04091386 0,08877535 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04091386 0,08869168 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04091386 0,08860817 ! muscle adaptation GO:0043500 12 7 0,000 0,04091386 0,08852481 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04091386 0,08844161 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04091386 0,08835857 ! retina homeostasis GO:0001895 9 7 0,000 0,04091386 0,08827568 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04091386 0,08819295 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04091386 0,08811037 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04091386 0,08802794 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04091386 0,08794568 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04091386 0,08786356 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04091386 0,0877816 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04091386 0,08769979 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,04105329 0,08791673 ! DNA catabolic process GO:0006308 67 54 1,000 0,04105329 0,08783494 ! detection of external stimulus GO:0009581 66 54 1,000 0,04105329 0,08775331 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,04105329 0,08767183 ! mesoderm development GO:0007498 76 55 1,000 0,04244068 0,09055062 ! carbohydrate transport GO:0008643 74 57 1,000 0,04526747 0,0964923 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,04526747 0,09640296 GO:0048609|reproductive process in a multicellular organism, ! camera-type eye development GO:0043010 88 57 1,000 0,04526747 0,09631378 ! secondary metabolic process GO:0019748 84 57 1,000 0,04526747 0,09622476 ! gonad development GO:0008406 79 57 1,000 0,04526747 0,09613591 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04662172 0,09892063 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04662172 0,09882946 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,04662172 0,09873846 ! axon extension GO:0048675 11 8 0,000 0,04662172 0,09864762 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04662172 0,09855695 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04662172 0,09846645 ! associative learning GO:0008306 15 8 0,000 0,04662172 0,09837611 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04662172 0,09828594 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04662172 0,09819594 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,04662172 0,0981061 ! phosphate transport GO:0006817 10 8 0,000 0,04662172 0,09801642 ! N-glycan processing GO:0006491 12 8 0,000 0,04662172 0,09792691 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04662172 0,09783756 ! UTP metabolic process GO:0046051 8 8 0,000 0,04662172 0,09774837 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04662172 0,09765935 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04662172 0,09757049 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04662172 0,09748179 ! succinate metabolic process GO:0006105 14 8 0,000 0,04662172 0,09739325 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04662172 0,09730487 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04662172 0,09721665 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04662172 0,09712859 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04662172 0,09704069 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04662172 0,09695295 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,04662172 0,09686537 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04662172 0,09677795 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04662172 0,09669068 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04662172 0,09660357 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04662172 0,09651662 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04662172 0,09642982 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,04662172 0,09634318 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04662172 0,0962567 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04662172 0,09617037 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04662172 0,0960842 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04662172 0,09599818 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04662172 0,09591231 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04662172 0,0958266 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04662172 0,09574104 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04662172 0,09565563 ! macrophage activation GO:0042116 12 8 0,000 0,04662172 0,09557038 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04662172 0,09548528 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04662172 0,09540032 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04662172 0,09531552 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04662172 0,09523087 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04662172 0,09514637 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04662172 0,09506203 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04662172 0,09497782 ! ruffle organization GO:0031529 11 8 0,000 0,04662172 0,09489377 ! osteoblast development GO:0002076 13 8 0,000 0,04662172 0,09480987 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04662172 0,09472612 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04662172 0,09464251 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04662172 0,09455905 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04662172 0,09447574 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04662172 0,09439257 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04662172 0,09430956 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04662172 0,09422668 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04662172 0,09414395 ! brain morphogenesis GO:0048854 20 8 0,000 0,04662172 0,09406137 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04662172 0,09397893 ! segment specification GO:0007379 10 8 0,000 0,04662172 0,09389664 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,04662172 0,09381449 ! cellular extravasation GO:0045123 11 8 0,000 0,04662172 0,09373249 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04662172 0,09365062 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04662172 0,0935689 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04662172 0,09348733 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04662172 0,09340589 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04662172 0,0933246 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04662172 0,09324345 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04662172 0,09316244 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04662172 0,09308157 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04662172 0,09300084 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04662172 0,09292025 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04662172 0,0928398 ! icosanoid secretion GO:0032309 12 8 0,000 0,04662172 0,09275948 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04662172 0,09267931 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04662172 0,09259928 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04662172 0,09251938 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04662172 0,09243962 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04662172 0,09236 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04662172 0,09228052 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04662172 0,09220117 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04662172 0,09212196 ! sterol catabolic process GO:0016127 9 8 0,000 0,04662172 0,09204289 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04662172 0,09196395 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04662172 0,09188515 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04662172 0,09180648 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04662172 0,09172794 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04662172 0,09164954 ! prophase GO:0051324 11 8 0,000 0,04662172 0,09157128 ! S phase GO:0051320 8 8 0,000 0,04662172 0,09149314 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04662172 0,09141514 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,04662172 0,09133728 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04662172 0,09125954 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04662172 0,09118194 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04662172 0,09110447 ! hormone catabolic process GO:0042447 13 8 0,000 0,04662172 0,09102713 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04662172 0,09094993 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04662172 0,09087285 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04662172 0,09079591 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04662172 0,09071909 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04662172 0,0906424 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04662172 0,09056585 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04662172 0,09048942 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04662172 0,09041312 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04662172 0,09033695 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04662172 0,09026091 ! regulation of embryonic development GO:0045995 16 8 0,000 0,04662172 0,090185 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04662172 0,09010921 GO:0000076|DNA replication checkpoint, ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,04670638 0,09019703 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,04816195 0,09292994 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,04963396 0,09568994 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,05112214 0,09847649 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,05112214 0,09839409 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,05112214 0,09831182 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,05229594 0,10048511 ! regulation of developmental growth GO:0048638 13 9 0,000 0,05229594 0,10040123 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,05229594 0,10031749 ! telencephalon cell migration GO:0022029 16 9 0,000 0,05229594 0,10023389 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05229594 0,10015044 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05229594 0,10006712 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05229594 0,09998393 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05229594 0,09990089 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05229594 0,09981799 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05229594 0,09973522 ! GTP metabolic process GO:0046039 9 9 0,000 0,05229594 0,09965259 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05229594 0,09957009 ! social behavior GO:0035176 14 9 0,000 0,05229594 0,09948774 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05229594 0,09940551 ! artery development GO:0060840 19 9 0,000 0,05229594 0,09932343 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05229594 0,09924148 ! regulation of glycolysis GO:0006110 15 9 0,000 0,05229594 0,09915966 ! response to pain GO:0048265 16 9 0,000 0,05229594 0,09907798 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05229594 0,09899644 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05229594 0,09891503 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05229594 0,09883375 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05229594 0,09875261 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,05229594 0,09867159 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05229594 0,09859072 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05229594 0,09850997 ! protein targeting to ER GO:0045047 19 9 0,000 0,05229594 0,09842936 ! endoderm development GO:0007492 12 9 0,000 0,05229594 0,09834887 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05229594 0,09826852 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05229594 0,0981883 ! arginine catabolic process GO:0006527 10 9 0,000 0,05229594 0,09810822 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05229594 0,09802826 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05229594 0,09794843 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,05229594 0,09786873 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05229594 0,09778917 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05229594 0,09770973 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05229594 0,09763042 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05229594 0,09755124 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05229594 0,09747218 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05229594 0,09739326 ! mannose metabolic process GO:0006013 9 9 0,000 0,05229594 0,09731446 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05229594 0,09723579 ! receptor clustering GO:0043113 15 9 0,000 0,05229594 0,09715725 ! epithelial cell development GO:0002064 10 9 0,000 0,05229594 0,09707883 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05229594 0,09700054 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05229594 0,09692238 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05229594 0,09684434 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05229594 0,09676643 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05229594 0,09668864 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,05229594 0,09661098 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05229594 0,09653345 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05229594 0,09645603 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05229594 0,09637874 ! DNA ligation GO:0006266 14 9 0,000 0,05229594 0,09630158 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05229594 0,09622454 ! response to amine stimulus GO:0014075 13 9 0,000 0,05229594 0,09614762 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05229594 0,09607083 ! erythrocyte development GO:0048821 11 9 0,000 0,05229594 0,09599415 ! renal water homeostasis GO:0003091 14 9 0,000 0,05229594 0,0959176 ! postreplication repair GO:0006301 11 9 0,000 0,05229594 0,09584117 ! mRNA cleavage GO:0006379 13 9 0,000 0,05229594 0,09576487 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05229594 0,09568868 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,05229594 0,09561262 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,05229594 0,09553667 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05229594 0,09546085 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05229594 0,09538515 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05229594 0,09530957 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,05229594 0,0952341 ! acid secretion GO:0046717 14 9 0,000 0,05229594 0,09515876 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05229594 0,09508354 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05229594 0,09500843 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05229594 0,09493344 ! purine base metabolic process GO:0006144 18 9 0,000 0,05229594 0,09485857 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05229594 0,09478382 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05229594 0,09470919 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05229594 0,09463468 ! detection of calcium ion GO:0005513 13 9 0,000 0,05229594 0,09456028 ! blastocyst formation GO:0001825 12 9 0,000 0,05229594 0,094486 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05229594 0,09441183 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05229594 0,09433778 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05229594 0,09426385 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05229594 0,09419003 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05229594 0,09411633 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05229594 0,09404275 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05229594 0,09396928 ! prepulse inhibition GO:0060134 14 9 0,000 0,05229594 0,09389592 ! embryonic placenta development GO:0001892 12 9 0,000 0,05229594 0,09382268 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05229594 0,09374955 ! insulin secretion GO:0030073 17 9 0,000 0,05229594 0,09367654 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05229594 0,09360364 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05229594 0,09353085 ! nucleus localization GO:0051647 15 9 0,000 0,05229594 0,09345818 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05229594 0,09338562 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,05262628 0,09390259 ! organelle localization GO:0051640 96 62 1,000 0,05262628 0,0938298 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,05414612 0,09646481 ! regulation of lipase activity GO:0060191 109 63 1,000 0,05414612 0,09639014 ! adaptive immune response GO:0002250 94 64 1,000 0,05568143 0,09904662 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,05723197 0,10172607 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,05723197 0,10164752 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,05723197 0,10156909 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,05723197 0,10149077 ! protein oligomerization GO:0051259 100 65 1,000 0,05723197 0,10141258 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,05793672 0,10258233 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05793672 0,10250342 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05793672 0,10242464 ! thyroid gland development GO:0030878 19 10 0,000 0,05793672 0,10234597 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,05793672 0,10226742 ! synapsis GO:0007129 13 10 0,000 0,05793672 0,102189 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05793672 0,10211069 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05793672 0,1020325 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,05793672 0,10195444 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05793672 0,10187649 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,05793672 0,10179866 ! androgen metabolic process GO:0008209 13 10 0,000 0,05793672 0,10172095 ! phospholipid efflux GO:0033700 16 10 0,000 0,05793672 0,10164336 ! hippocampus development GO:0021766 19 10 0,000 0,05793672 0,10156589 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,05793672 0,10148854 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05793672 0,1014113 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,05793672 0,10133418 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,05793672 0,10125718 ! pathogenesis GO:0009405 13 10 0,000 0,05793672 0,1011803 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05793672 0,10110353 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05793672 0,10102688 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05793672 0,10095034 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,05793672 0,10087392 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05793672 0,10079762 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05793672 0,10072143 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05793672 0,10064536 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05793672 0,1005694 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05793672 0,10049355 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05793672 0,10041782 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05793672 0,10034221 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05793672 0,1002667 ! forebrain cell migration GO:0021885 17 10 0,000 0,05793672 0,10019132 ! lipid digestion GO:0044241 15 10 0,000 0,05793672 0,10011604 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05793672 0,10004088 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05793672 0,09996583 ! UV protection GO:0009650 14 10 0,000 0,05793672 0,09989089 ! entry into host cell GO:0030260 20 10 0,000 0,05793672 0,09981607 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05793672 0,09974135 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,05793672 0,09966675 ! regulation of organ growth GO:0046620 11 10 0,000 0,05793672 0,09959226 ! response to dsRNA GO:0043331 18 10 0,000 0,05793672 0,09951789 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05793672 0,09944362 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05793672 0,09936946 ! embryonic axis specification GO:0000578 12 10 0,000 0,05793672 0,09929542 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05793672 0,09922148 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05793672 0,09914766 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,05793672 0,09907394 ! fucose catabolic process GO:0019317 16 10 0,000 0,05793672 0,09900033 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,05793672 0,09892684 ! protein sumoylation GO:0016925 12 10 0,000 0,05793672 0,09885345 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05793672 0,09878017 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05793672 0,098707 ! zymogen activation GO:0031638 14 10 0,000 0,05793672 0,09863394 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05793672 0,09856098 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05793672 0,09848814 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,05793672 0,0984154 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05793672 0,09834277 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05793672 0,09827024 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05793672 0,09819783 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05793672 0,09812552 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05793672 0,09805331 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,05793672 0,09798121 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,05793672 0,09790922 ! detection of bacterium GO:0016045 10 10 0,000 0,05793672 0,09783733 ! activation of innate immune response GO:0002218 10 10 0,000 0,05793672 0,09776555 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05793672 0,09769388 ! developmental induction GO:0031128 13 10 0,000 0,05793672 0,09762231 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05793672 0,09755084 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,05793672 0,09747948 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05793672 0,09740822 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05793672 0,09733707 ! learning or memory GO:0007611 123 68 1,000 0,06197272 0,1040418 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,06197272 0,10396591 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,06197272 0,10389013 ! rhythmic process GO:0048511 105 68 1,000 0,06197272 0,10381447 ! rRNA transcription GO:0009303 17 11 0,000 0,06354424 0,10636954 ! respiratory burst GO:0045730 14 11 0,000 0,06354424 0,10629218 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,06354424 0,10621493 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,06354424 0,1061378 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,06354424 0,10606077 ! virus-host interaction GO:0019048 17 11 0,000 0,06354424 0,10598386 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,06354424 0,10590706 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,06354424 0,10583037 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,06354424 0,1057538 ! RNA polyadenylation GO:0043631 19 11 0,000 0,06354424 0,10567733 ! mating GO:0007618 14 11 0,000 0,06354424 0,10560097 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,06354424 0,10552473 ! T cell proliferation GO:0042098 20 11 0,000 0,06354424 0,10544859 ! bone resorption GO:0045453 16 11 0,000 0,06354424 0,10537256 ! regulated secretory pathway GO:0045055 14 11 0,000 0,06354424 0,10529665 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,06354424 0,10522084 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,06354424 0,10514514 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,06354424 0,10506955 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,06354424 0,10499407 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,06354424 0,1049187 ! syncytium formation GO:0006949 15 11 0,000 0,06354424 0,10484343 ! plasma membrane organization GO:0007009 18 11 0,000 0,06354424 0,10476828 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,06354424 0,10469323 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,06354424 0,10461829 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,06354424 0,10454345 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,06354424 0,10446872 ! adult heart development GO:0007512 11 11 0,000 0,06354424 0,1043941 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,06354424 0,10431959 ! temperature homeostasis GO:0001659 16 11 0,000 0,06354424 0,10424518 ! L-glutamate transport GO:0015813 16 11 0,000 0,06354424 0,10417088 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,06354424 0,10409668 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,06354424 0,10402259 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,06354424 0,10394861 ! stem cell development GO:0048864 29 11 0,000 0,06354424 0,10387473 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,06354424 0,10380096 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,06354424 0,10372729 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,06354424 0,10365372 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,06354424 0,10358026 ! vasoconstriction GO:0042310 15 11 0,000 0,06354424 0,1035069 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,06354424 0,10343365 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,06354424 0,1033605 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,06354424 0,10328745 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,06354424 0,10321451 ! ribosome assembly GO:0042255 13 11 0,000 0,06354424 0,10314167 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,06354424 0,10306893 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,06354424 0,1029963 ! chromatin silencing GO:0006342 19 11 0,000 0,06354424 0,10292376 ! nucleosome positioning GO:0016584 13 11 0,000 0,06354424 0,10285133 ! regulation of isotype switching GO:0045191 19 11 0,000 0,06354424 0,10277901 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,06354424 0,10270678 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,06354424 0,10263465 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,06354424 0,10256263 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,06354424 0,1024907 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,06354424 0,10241888 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,06354424 0,10234716 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,06354424 0,10227554 ! male genitalia development GO:0030539 13 11 0,000 0,06354424 0,10220402 ! cholesterol efflux GO:0033344 19 11 0,000 0,06354424 0,1021326 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,06354424 0,10206127 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,06354424 0,10199005 ! germ cell migration GO:0008354 18 11 0,000 0,06354424 0,10191893 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,06354424 0,10184791 ! defense response to fungus GO:0050832 12 11 0,000 0,06354424 0,10177698 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,06354424 0,10170616 ! lysogeny GO:0030069 18 11 0,000 0,06354424 0,10163543 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,06354424 0,1015648 ! acrosome reaction GO:0007340 13 11 0,000 0,06354424 0,10149427 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,06354424 0,10142383 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,06358192 0,1014136 ! response to metal ion GO:0010038 103 70 1,000 0,06520522 0,1039307 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,06684239 0,10646642 ! muscle cell differentiation GO:0042692 104 71 1,000 0,06684239 0,10639274 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,06684239 0,10631916 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,06849323 0,10886968 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,06849323 0,10879449 ! lactation GO:0007595 20 12 0,000 0,0691187 0,10971222 ! reproductive cellular process GO:0048610 14 12 0,000 0,0691187 0,10963655 ! tRNA modification GO:0006400 14 12 0,000 0,0691187 0,109561 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,0691187 0,10948554 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,0691187 0,10941019 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,0691187 0,10933494 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,0691187 0,1092598 ! non-recombinational repair GO:0000726 19 12 0,000 0,0691187 0,10918476 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,0691187 0,10910982 ! peroxisomal transport GO:0043574 21 12 0,000 0,0691187 0,10903498 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,0691187 0,10896025 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,0691187 0,10888562 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,0691187 0,10881109 ! heart looping GO:0001947 15 12 0,000 0,0691187 0,10873667 ! palate development GO:0060021 15 12 0,000 0,0691187 0,10866234 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,0691187 0,10858812 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,0691187 0,108514 ! arginine metabolic process GO:0006525 13 12 0,000 0,0691187 0,10843998 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,0691187 0,10836606 ! methionine metabolic process GO:0006555 13 12 0,000 0,0691187 0,10829224 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,0691187 0,10821852 ! Golgi organization GO:0007030 18 12 0,000 0,0691187 0,1081449 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,0691187 0,10807138 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,0691187 0,10799796 ! monoamine transport GO:0015844 13 12 0,000 0,0691187 0,10792465 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0691187 0,10785143 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,0691187 0,10777831 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,0691187 0,10770529 ! L-amino acid transport GO:0015807 20 12 0,000 0,0691187 0,10763237 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,0691187 0,10755954 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,0691187 0,10748682 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,0691187 0,10741419 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,0691187 0,10734166 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,0691187 0,10726923 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,0691187 0,1071969 ! cerebellum development GO:0021549 13 12 0,000 0,0691187 0,10712467 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,0691187 0,10705253 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,0691187 0,10698049 ! histone acetylation GO:0016573 23 12 0,000 0,0691187 0,10690854 ! histone methylation GO:0016571 15 12 0,000 0,0691187 0,1068367 ! autonomic nervous system development GO:0048483 23 12 0,000 0,0691187 0,10676495 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,0691187 0,10669329 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,0691187 0,10662173 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,0691187 0,10655027 ! intestinal absorption GO:0050892 19 12 0,000 0,0691187 0,1064789 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,0691187 0,10640763 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,0691187 0,10633646 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,0691187 0,10626538 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,0691187 0,10619439 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,0691187 0,1061235 ! microspike assembly GO:0030035 23 12 0,000 0,0691187 0,1060527 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,0691187 0,105982 ! response to cold GO:0009409 14 12 0,000 0,0691187 0,1059114 ! regulation of blood pressure GO:0008217 107 73 1,000 0,07015751 0,1074316 ! digestion GO:0007586 97 74 1,000 0,07183502 0,10992717 ! response to inorganic substance GO:0010035 115 75 1,000 0,07352554 0,11243932 ! regulation of ligase activity GO:0051340 114 75 1,000 0,07352554 0,11236461 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,07466029 0,11402302 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,07466029 0,11394736 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07466029 0,1138718 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07466029 0,11379634 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,07466029 0,11372097 ! water transport GO:0006833 17 13 0,000 0,07466029 0,11364571 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,07466029 0,11357055 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07466029 0,11349549 ! lipid localization GO:0010876 24 13 0,000 0,07466029 0,11342052 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07466029 0,11334566 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,07466029 0,11327089 ! organelle fusion GO:0048284 28 13 0,000 0,07466029 0,11319622 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07466029 0,11312165 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,07466029 0,11304718 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07466029 0,11297281 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07466029 0,11289853 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,07466029 0,11282436 ! glutamate metabolic process GO:0006536 18 13 0,000 0,07466029 0,11275028 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07466029 0,11267629 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07466029 0,11260241 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,07466029 0,11252862 ! NAD metabolic process GO:0019674 21 13 0,000 0,07466029 0,11245493 ! bone mineralization GO:0030282 15 13 0,000 0,07466029 0,11238133 ! regulation of exocytosis GO:0017157 17 13 0,000 0,07466029 0,11230783 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,07466029 0,11223443 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,07466029 0,11216112 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07466029 0,11208791 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,07466029 0,11201479 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,07466029 0,11194177 ! genitalia development GO:0048806 15 13 0,000 0,07466029 0,11186884 ! tissue regeneration GO:0042246 21 13 0,000 0,07466029 0,11179601 ! cofactor transport GO:0051181 19 13 0,000 0,07466029 0,11172327 ! NADP metabolic process GO:0006739 18 13 0,000 0,07466029 0,11165063 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07466029 0,11157808 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,07466029 0,11150563 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07466029 0,11143327 ! gas transport GO:0015669 18 13 0,000 0,07466029 0,11136101 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07466029 0,11128883 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,07466029 0,11121676 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07466029 0,11114477 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07466029 0,11107288 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07466029 0,11100108 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,07466029 0,11092937 ! amine biosynthetic process GO:0009309 97 76 1,000 0,07522887 0,111702 ! tRNA metabolic process GO:0006399 95 76 1,000 0,07522887 0,11162993 ! sex differentiation GO:0007548 105 77 1,000 0,07694479 0,11410253 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,07694479 0,11402901 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,07694479 0,11395559 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,08016921 0,11865456 ! superoxide anion generation GO:0042554 18 14 0,000 0,08016921 0,11857826 ! neuron maturation GO:0042551 21 14 0,000 0,08016921 0,11850205 ! regulation of S phase GO:0033261 18 14 0,000 0,08016921 0,11842594 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,08016921 0,11834993 ! myotube differentiation GO:0014902 21 14 0,000 0,08016921 0,11827401 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,08016921 0,1181982 ! inositol metabolic process GO:0006020 20 14 0,000 0,08016921 0,11812248 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08016921 0,11804686 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08016921 0,11797133 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08016921 0,1178959 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08016921 0,11782057 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08016921 0,11774533 ! response to cAMP GO:0051591 19 14 0,000 0,08016921 0,11767019 ! limbic system development GO:0021761 25 14 0,000 0,08016921 0,11759515 ! startle response GO:0001964 21 14 0,000 0,08016921 0,1175202 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,08016921 0,11744534 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08016921 0,11737058 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08016921 0,11729592 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08016921 0,11722135 ! glycine metabolic process GO:0006544 22 14 0,000 0,08016921 0,11714688 ! pituitary gland development GO:0021983 23 14 0,000 0,08016921 0,1170725 ! lysosomal transport GO:0007041 20 14 0,000 0,08016921 0,11699822 ! regulation of heart rate GO:0002027 23 14 0,000 0,08016921 0,11692403 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08016921 0,11684993 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,08016921 0,11677593 ! embryo implantation GO:0007566 27 14 0,000 0,08016921 0,11670202 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08016921 0,1166282 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08016921 0,11655448 ! axon cargo transport GO:0008088 27 14 0,000 0,08016921 0,11648085 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08016921 0,11640732 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,08016921 0,11633387 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08016921 0,11626052 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08016921 0,11618726 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,08016921 0,1161141 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,08016921 0,11604102 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,08016921 0,11596804 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08016921 0,11589515 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08016921 0,11582235 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,08016921 0,11574965 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,08016921 0,11567703 ! muscle maintenance GO:0046716 19 14 0,000 0,08016921 0,11560451 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,08016921 0,11553207 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,08016921 0,11545973 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08016921 0,11538748 ! cilium assembly GO:0042384 20 14 0,000 0,08016921 0,11531531 ! peptide hormone secretion GO:0030072 23 14 0,000 0,08016921 0,11524324 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,08216609 0,11803998 GO:0010498|proteasomal protein catabolic process, ! forebrain development GO:0030900 131 80 1,000 0,08216609 0,11796629 ! mRNA transport GO:0051028 121 81 1,000 0,08393035 0,12042409 ! regulation of neurological system process GO:0031644 122 81 1,000 0,08393035 0,12034901 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,08564565 0,12273208 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,08564565 0,12265566 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,08564565 0,12257934 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,08564565 0,12250311 ! skin development GO:0043588 25 15 0,000 0,08564565 0,12242697 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,08564565 0,12235093 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,08564565 0,12227498 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,08564565 0,12219913 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,08564565 0,12212337 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,08564565 0,1220477 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,08564565 0,12197213 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,08564565 0,12189665 ! adult walking behavior GO:0007628 25 15 0,000 0,08564565 0,12182127 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,08564565 0,12174598 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,08564565 0,12167078 ! myoblast differentiation GO:0045445 27 15 0,000 0,08564565 0,12159568 ! centrosome cycle GO:0007098 16 15 0,000 0,08564565 0,12152066 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,08564565 0,12144574 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,08564565 0,12137091 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,08564565 0,12129618 ! cerebral cortex development GO:0021987 29 15 0,000 0,08564565 0,12122153 ! response to osmotic stress GO:0006970 22 15 0,000 0,08564565 0,12114698 ! vesicle coating GO:0006901 25 15 0,000 0,08564565 0,12107252 ! DNA integration GO:0015074 22 15 0,000 0,08564565 0,12099815 ! peptide secretion GO:0002790 27 15 0,000 0,08564565 0,12092388 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,08564565 0,12084969 ! regulation of vasodilation GO:0042312 24 15 0,000 0,08564565 0,12077559 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,08564565 0,12070159 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,08564565 0,12062768 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,08564565 0,12055385 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,08564565 0,12048012 ! biomineral formation GO:0031214 18 15 0,000 0,08564565 0,12040648 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,08564565 0,12033292 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,08564565 0,12025946 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,08564565 0,12018609 ! organic cation transport GO:0015695 19 15 0,000 0,08564565 0,1201128 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,08564565 0,12003961 GO:0033014|tetrapyrrole biosynthetic process, ! peptide hormone processing GO:0016486 19 15 0,000 0,08564565 0,1199665 ! detection of stimulus GO:0051606 108 82 1,000 0,0857062 0,11997824 ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,08749343 0,12240565 ! protein secretion GO:0009306 27 16 0,000 0,09108979 0,12735959 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,09108979 0,12728221 ! hormone secretion GO:0046879 25 16 0,000 0,09108979 0,12720493 ! bone remodeling GO:0046849 24 16 0,000 0,09108979 0,12712774 ! endothelial cell migration GO:0043542 22 16 0,000 0,09108979 0,12705065 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,09108979 0,12697365 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,09108979 0,12689674 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09108979 0,12681993 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,09108979 0,12674321 ! glial cell development GO:0021782 24 16 0,000 0,09108979 0,12666658 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,09108979 0,12659004 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,09108979 0,1265136 ! protein polyubiquitination GO:0000209 26 16 0,000 0,09108979 0,12643725 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,09108979 0,12636099 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,09108979 0,12628482 ! fructose metabolic process GO:0006000 20 16 0,000 0,09108979 0,12620875 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,09108979 0,12613277 ! protein export from nucleus GO:0006611 24 16 0,000 0,09108979 0,12605687 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,09108979 0,12598107 ! DNA replication initiation GO:0006270 25 16 0,000 0,09108979 0,12590536 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,09108979 0,12582974 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,09108979 0,12575422 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,09108979 0,12567878 ! diencephalon development GO:0021536 25 16 0,000 0,09108979 0,12560343 ! neural crest cell migration GO:0001755 24 16 0,000 0,09108979 0,12552817 ! G1 phase GO:0051318 27 16 0,000 0,09108979 0,12545301 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,09108979 0,12537793 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,09108979 0,12530294 ! steroid catabolic process GO:0006706 22 16 0,000 0,09108979 0,12522805 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,09108979 0,12515324 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,09108979 0,12507852 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,09108979 0,12500389 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,09108979 0,12492935 ! sperm-egg recognition GO:0035036 16 16 0,000 0,09108979 0,1248549 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,09108979 0,12478054 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,09108979 0,12470626 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,09108979 0,12463208 ! negative regulation of translation GO:0017148 22 16 0,000 0,09108979 0,12455798 ! transcription initiation GO:0006352 118 85 1,000 0,09110127 0,12449965 ! cellular defense response GO:0006968 102 87 1,000 0,09475233 0,12941233 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,09475233 0,12933552 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 1,000 0,09475233 0,12925881 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,09475233 0,12918219 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,09650183 0,13148946 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,09650183 0,13141161 ! negative regulation of defense response GO:0031348 19 17 0,000 0,09650183 0,13133385 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,09650183 0,13125619 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,09650183 0,13117861 ! glycerol metabolic process GO:0006071 20 17 0,000 0,09650183 0,13110113 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,09650183 0,13102374 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,09650183 0,13094644 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,09650183 0,13086923 ! signal complex assembly GO:0007172 29 17 0,000 0,09650183 0,13079211 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,09650183 0,13071508 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,09650183 0,13063815 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,09650183 0,1305613 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,09650183 0,13048455 ! memory GO:0007613 25 17 0,000 0,09650183 0,13040788 ! keratinization GO:0031424 17 17 0,000 0,09650183 0,1303313 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,09650183 0,13025482 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,09650183 0,13017842 ! retinoid metabolic process GO:0001523 22 17 0,000 0,09650183 0,13010212 GO:0016101|diterpenoid metabolic process, ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,09650183 0,1300259 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,09650183 0,12994977 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,09650183 0,12987373 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,09650183 0,12979778 ! membrane budding GO:0006900 29 17 0,000 0,09650183 0,12972192 ! heme metabolic process GO:0042168 27 17 0,000 0,09650183 0,12964615 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,09650183 0,12957047 ! body fluid secretion GO:0007589 27 17 0,000 0,09650183 0,12949487 ! stem cell differentiation GO:0048863 36 17 0,000 0,09650183 0,12941937 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,09650183 0,12934395 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,09650183 0,12926861 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,09650183 0,12919337 ! sensory perception of pain GO:0019233 23 17 0,000 0,09650183 0,12911821 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,09650183 0,12904315 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,09650183 0,12896816 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,09650183 0,12889327 ! synaptogenesis GO:0007416 24 17 0,000 0,09650183 0,12881846 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,09650183 0,12874374 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,09650183 0,12866911 ! cell-cell junction organization GO:0045216 25 17 0,000 0,09650183 0,12859456 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,09650183 0,1285201 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,09650183 0,12844572 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,09650183 0,12837144 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,09650183 0,12829723 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,0965936 0,12834505 ! establishment of RNA localization GO:0051236 128 88 1,000 0,0965936 0,12827094 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! reproductive developmental process GO:0003006 127 89 1,000 0,09844511 0,13065421 ! regulation of T cell activation GO:0050863 128 89 1,000 0,09844511 0,13057886 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,10188195 0,13505965 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,10188195 0,13498185 ! positive regulation of translation GO:0045727 28 18 0,000 0,10188195 0,13490414 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,10188195 0,13482652 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,10188195 0,13474899 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,10188195 0,13467155 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,10188195 0,13459419 ! cAMP metabolic process GO:0046058 33 18 0,000 0,10188195 0,13451693 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,10188195 0,13443975 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,10188195 0,13436267 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,10188195 0,13428567 ! axis specification GO:0009798 26 18 0,000 0,10188195 0,13420876 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,10188195 0,13413193 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,10188195 0,1340552 ! pancreas development GO:0031016 26 18 0,000 0,10188195 0,13397855 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,10188195 0,13390199 ! glutamine metabolic process GO:0006541 23 18 0,000 0,10188195 0,13382552 ! response to retinoic acid GO:0032526 25 18 0,000 0,10188195 0,13374914 ! pigmentation during development GO:0048066 31 18 0,000 0,10188195 0,13367284 ! central nervous system neuron development GO:0021954 30 18 0,000 0,10188195 0,13359663 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,10188195 0,13352051 ! fucose metabolic process GO:0006004 26 18 0,000 0,10188195 0,13344447 ! response to fungus GO:0009620 19 18 0,000 0,10188195 0,13336852 ! peptide cross-linking GO:0018149 31 18 0,000 0,10188195 0,13329266 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,10188195 0,13321688 ! heart process GO:0003015 27 18 0,000 0,10188195 0,13314119 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,10188195 0,13306558 GO:0006692|prostanoid metabolic process, ! somitogenesis GO:0001756 24 18 0,000 0,10188195 0,13299006 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,10188195 0,13291463 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,10188195 0,13283928 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,10188195 0,13276402 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,10188195 0,13268884 ! vitamin transport GO:0051180 24 18 0,000 0,10188195 0,13261375 ! hormone transport GO:0009914 27 18 0,000 0,10188195 0,13253874 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,10188195 0,13246382 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,10188195 0,13238898 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,10188195 0,13231422 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,10188195 0,13223955 ! cell-cell recognition GO:0009988 20 18 0,000 0,10188195 0,13216497 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,10188195 0,13209047 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,10188195 0,13201605 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,10188195 0,13194172 ! RNA localization GO:0006403 135 91 1,000 0,10217812 0,13225081 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,10405926 0,13460985 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,10594992 0,13697854 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,10594992 0,13690158 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,10723034 0,13847826 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,10723034 0,13840055 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,10723034 0,13832293 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,10723034 0,1382454 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,10723034 0,13816795 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,10723034 0,13809059 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,10723034 0,13801331 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,10723034 0,13793612 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,10723034 0,13785902 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,10723034 0,137782 ! sensory perception of taste GO:0050909 23 19 0,000 0,10723034 0,13770507 ! smooth muscle contraction GO:0006939 36 19 0,000 0,10723034 0,13762823 ! peroxisome organization GO:0007031 29 19 0,000 0,10723034 0,13755147 ! digestive system process GO:0022600 30 19 0,000 0,10723034 0,1374748 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,10723034 0,13739821 ! response to vitamin A GO:0033189 26 19 0,000 0,10723034 0,13732171 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,10723034 0,13724529 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,10723034 0,13716896 ! sex determination GO:0007530 29 19 0,000 0,10723034 0,13709271 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,10723034 0,13701655 ! plasma membrane fusion GO:0045026 23 19 0,000 0,10723034 0,13694047 ! cytolysis GO:0019835 20 19 0,000 0,10723034 0,13686448 ! vasodilation GO:0042311 33 19 0,000 0,10723034 0,13678857 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,10723034 0,13671274 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,10723034 0,136637 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,10723034 0,13656134 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,10723034 0,13648577 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,10723034 0,13641028 ! sarcomere organization GO:0045214 23 19 0,000 0,10723034 0,13633487 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,10723034 0,13625955 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,10723034 0,13618431 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,10723034 0,13610915 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,10723034 0,13603408 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,10723034 0,13595909 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,10723034 0,13588418 ! protein stabilization GO:0050821 26 19 0,000 0,10723034 0,13580935 ! regulation of binding GO:0051098 151 95 1,000 0,10975908 0,13893555 ! in utero embryonic development GO:0001701 147 96 1,000 0,11167724 0,14128583 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,11167724 0,14120816 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,11254719 0,14222996 ! iron ion transport GO:0006826 37 20 0,000 0,11254719 0,14215185 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,11254719 0,14207383 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,11254719 0,1419959 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,11254719 0,14191805 ! response to vitamin GO:0033273 29 20 0,000 0,11254719 0,14184029 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,11254719 0,14176261 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,11254719 0,14168502 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,11254719 0,14160751 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,11254719 0,14153009 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,11254719 0,14145275 ! chromosome condensation GO:0030261 31 20 0,000 0,11254719 0,14137549 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,11254719 0,14129832 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,11254719 0,14122124 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,11254719 0,14114423 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,11254719 0,14106732 ! pallium development GO:0021543 38 20 0,000 0,11254719 0,14099048 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,11254719 0,14091373 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,11254719 0,14083707 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,11254719 0,14076048 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,11254719 0,14068398 ! alditol metabolic process GO:0019400 24 20 0,000 0,11254719 0,14060756 ! actin filament-based movement GO:0030048 34 20 0,000 0,11254719 0,14053123 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,11783267 0,14705108 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,11783267 0,14697133 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,11783267 0,14689167 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,11783267 0,1468121 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,11783267 0,14673261 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,11783267 0,14665321 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,11783267 0,1465739 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,11783267 0,14649467 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,11783267 0,14641552 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,11783267 0,14633647 ! protein amino acid acylation GO:0043543 37 21 0,000 0,11783267 0,14625749 ! vesicle docking GO:0048278 27 21 0,000 0,11783267 0,14617861 ! phototransduction GO:0007602 25 21 0,000 0,11783267 0,1460998 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,11783267 0,14602109 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,11783267 0,14594245 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,11783267 0,14586391 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,11783267 0,14578544 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,11783267 0,14570706 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,11783267 0,14562877 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,11783267 0,14555056 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,11783267 0,14547243 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,11783267 0,14539439 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,11783267 0,14531643 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,11783267 0,14523855 ! fatty acid transport GO:0015908 30 21 0,000 0,11783267 0,14516076 ! immunoglobulin production GO:0002377 33 21 0,000 0,11783267 0,14508305 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,11783267 0,14500542 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,11783267 0,14492788 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,11783267 0,14485042 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,11783267 0,14477304 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,11783267 0,14469575 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,11783267 0,14461854 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,11783267 0,14454141 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,11783267 0,14446436 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,11783267 0,14438739 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,11783267 0,14431051 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,11783267 0,14423371 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,12308697 0,15058513 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,12308697 0,15050507 ! viral genome replication GO:0019079 29 22 0,000 0,12308697 0,1504251 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,12308697 0,15034521 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,12308697 0,15026541 ! leukocyte adhesion GO:0007159 38 22 0,000 0,12308697 0,1501857 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,12308697 0,15010606 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,12308697 0,15002652 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,12308697 0,14994705 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,12308697 0,14986767 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,12308697 0,14978838 ! lysosome organization GO:0007040 37 22 0,000 0,12308697 0,14970917 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,12308697 0,14963004 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,12308697 0,149551 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,12308697 0,14947204 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,12308697 0,14939316 ! membrane depolarization GO:0051899 35 22 0,000 0,12308697 0,14931436 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,12308697 0,14923565 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,12308697 0,14915703 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,12308697 0,14907848 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,12308697 0,14900002 ! blastocyst development GO:0001824 37 22 0,000 0,12308697 0,14892164 ! neural tube closure GO:0001843 33 22 0,000 0,12308697 0,14884334 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,12308697 0,14876513 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,12831028 0,15499666 ! embryonic pattern specification GO:0009880 31 23 0,000 0,12831028 0,1549153 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,12831028 0,15483402 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,12831028 0,15475283 ! vesicle targeting GO:0006903 32 23 0,000 0,12831028 0,15467172 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,12831028 0,1545907 ! osteoblast differentiation GO:0001649 40 23 0,000 0,12831028 0,15450976 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,12831028 0,15442891 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,12831028 0,15434814 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,12831028 0,15426746 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,12831028 0,15418686 ! cell fate determination GO:0001709 45 23 0,000 0,12831028 0,15410634 ! pentose metabolic process GO:0019321 31 23 0,000 0,12831028 0,15402591 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,12831028 0,15394556 ! spermatid development GO:0007286 33 23 0,000 0,12831028 0,1538653 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,12831028 0,15378512 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,12831028 0,15370502 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,12831028 0,15362501 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,12831028 0,15354508 ! telomere organization GO:0032200 32 23 0,000 0,12831028 0,15346523 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,12831028 0,15338547 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,12831028 0,15330579 ! regulation of amine transport GO:0051952 38 23 0,000 0,12831028 0,15322619 ! liver development GO:0001889 40 23 0,000 0,12831028 0,15314668 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,13350277 0,15926161 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,13350277 0,15917904 ! initiation of viral infection GO:0019059 42 24 0,000 0,13350277 0,15909657 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,13350277 0,15901418 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,13350277 0,15893187 ! superoxide metabolic process GO:0006801 32 24 0,000 0,13350277 0,15884965 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,13350277 0,15876752 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,13350277 0,15868547 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,13350277 0,1586035 ! sperm motility GO:0030317 27 24 0,000 0,13350277 0,15852162 ! vacuole organization GO:0007033 39 24 0,000 0,13350277 0,15843982 ! receptor metabolic process GO:0043112 37 24 0,000 0,13350277 0,15835811 ! neural crest cell development GO:0014032 39 24 0,000 0,13350277 0,15827648 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,13350277 0,15819494 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,13350277 0,15811348 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,13350277 0,1580321 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,13350277 0,15795081 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,13350277 0,1578696 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,13350277 0,15778848 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,13866463 0,16380516 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,13866463 0,16372107 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,13866463 0,16363707 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,13866463 0,16355315 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,13866463 0,16346932 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,13866463 0,16338558 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,13866463 0,16330192 ! peptide transport GO:0015833 43 25 0,000 0,13866463 0,16321835 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,13866463 0,16313486 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,13866463 0,16305146 ! phospholipid transport GO:0015914 35 25 0,000 0,13866463 0,16296814 ! detection of light stimulus GO:0009583 30 25 0,000 0,13866463 0,16288491 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,13866463 0,16280176 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,13866463 0,1627187 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,14379603 0,16865419 ! translational initiation GO:0006413 43 26 0,000 0,14379603 0,16856823 ! circadian rhythm GO:0007623 42 26 0,000 0,14379603 0,16848236 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,14379603 0,16839657 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,14379603 0,16831088 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,14379603 0,16822527 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,14379603 0,16813974 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,14379603 0,16805431 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,14379603 0,16796896 ! regulation of coagulation GO:0050818 39 26 0,000 0,14379603 0,16788369 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,14889716 0,17375112 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,14889716 0,17366301 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,14889716 0,17357499 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,14889716 0,17348706 ! membrane docking GO:0022406 39 27 0,000 0,14889716 0,17339922 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,14889716 0,17331147 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,14889716 0,1732238 ! acute-phase response GO:0006953 42 27 0,000 0,14889716 0,17313623 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,14889716 0,17304874 ! myofibril assembly GO:0030239 36 27 0,000 0,14889716 0,17296134 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,14889716 0,17287403 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,14889716 0,17278681 ! natural killer cell activation GO:0030101 35 27 0,000 0,14889716 0,17269968 ! lipid oxidation GO:0034440 38 27 0,000 0,14889716 0,17261263 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,14889716 0,17252567 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,14889716 0,1724388 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,14889716 0,17235202 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 0,000 0,14889716 0,17226532 ! gene silencing GO:0016458 41 27 0,000 0,14889716 0,17217871 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,15396818 0,17795317 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,15396818 0,17786379 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,15396818 0,1777745 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,15396818 0,1776853 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,15396818 0,17759619 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,15396818 0,17750717 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,15396818 0,17741824 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,15396818 0,1773294 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,15396818 0,17724064 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,15396818 0,17715198 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,15396818 0,1770634 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,15396818 0,17697492 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,15396818 0,17688652 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,15396818 0,17679821 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,15396818 0,17670998 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,15396818 0,17662185 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,15396818 0,1765338 ! placenta development GO:0001890 37 28 0,000 0,15396818 0,17644584 ! regulation of B cell activation GO:0050864 42 28 0,000 0,15396818 0,17635797 ! regulation of innate immune response GO:0045088 38 29 0,000 0,15900927 0,18204148 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,15900927 0,18195091 ! protein targeting to membrane GO:0006612 53 29 0,000 0,15900927 0,18186043 ! mismatch repair GO:0006298 34 29 0,000 0,15900927 0,18177005 ! muscle cell development GO:0055001 38 29 0,000 0,15900927 0,18167975 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,15900927 0,18158954 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,15900927 0,18149942 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,16402062 0,1871267 ! organic anion transport GO:0015711 51 30 0,000 0,16402062 0,18703393 ! cholesterol transport GO:0030301 46 30 0,000 0,16402062 0,18694124 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,16402062 0,18684865 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,16402062 0,18675615 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,16402062 0,18666375 ! ceramide metabolic process GO:0006672 43 30 0,000 0,16402062 0,18657143 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,16402062 0,1864792 ! adult locomotory behavior GO:0008344 47 30 0,000 0,16402062 0,18638707 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,16402062 0,18629503 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,16402062 0,18620307 ! negative regulation of secretion GO:0051048 49 31 0,000 0,16900239 0,19176394 ! glial cell differentiation GO:0010001 55 31 0,000 0,16900239 0,19166938 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,16900239 0,19157491 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,16900239 0,19148054 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,16900239 0,19138626 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,16900239 0,19129208 ! segmentation GO:0035282 41 31 0,000 0,16900239 0,19119798 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,16900239 0,19110398 ! RNA modification GO:0009451 40 31 0,000 0,16900239 0,19101007 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,17395476 0,19651078 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,17395476 0,19641431 ! meiosis I GO:0007127 52 32 0,000 0,17395476 0,19631793 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,17395476 0,19622165 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,17395476 0,19612546 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,17395476 0,19602937 ! cytokine production GO:0001816 44 32 0,000 0,17395476 0,19593337 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,17395476 0,19583747 ! vesicle localization GO:0051648 47 32 0,000 0,17395476 0,19574166 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,17887789 0,20118296 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,17887789 0,20108463 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,17887789 0,2009864 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,17887789 0,20088826 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,17887789 0,20079022 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,17887789 0,20069227 ! sister chromatid segregation GO:0000819 46 33 0,000 0,17887789 0,20059442 ! actomyosin structure organization GO:0031032 43 33 0,000 0,17887789 0,20049666 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,17887789 0,200399 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,17887789 0,20030144 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,17887789 0,20020397 GO:0042593|glucose homeostasis, ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,17887789 0,20010659 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,17887789 0,20000931 ! regulation of proteolysis GO:0030162 50 33 0,000 0,17887789 0,19991213 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,17887789 0,19981503 ! cytokinesis GO:0000910 52 33 0,000 0,17887789 0,19971804 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,17887789 0,19962113 ! mRNA catabolic process GO:0006402 48 34 0,000 0,18377197 0,20498328 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,18377197 0,20488392 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,18377197 0,20478465 ! feeding behavior GO:0007631 45 34 0,000 0,18377197 0,20468548 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,18377197 0,20458641 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,18377197 0,20448743 ! neuron migration GO:0001764 46 34 0,000 0,18377197 0,20438855 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,18377197 0,20428977 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,18377197 0,20419108 ! polyol metabolic process GO:0019751 44 34 0,000 0,18377197 0,20409248 ! aerobic respiration GO:0009060 47 34 0,000 0,18377197 0,20399398 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,18863715 0,20929351 ! Notch signaling pathway GO:0007219 56 35 0,000 0,18863715 0,2091926 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,18863715 0,20909178 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,18863715 0,20899106 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,18863715 0,20889044 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,18863715 0,20878992 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,18863715 0,20868949 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,18863715 0,20858916 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,18863715 0,20848892 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,18863715 0,20838878 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,18863715 0,20828874 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,19347361 0,21352654 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 0,000 0,19347361 0,21342413 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,19347361 0,21332182 ! negative regulation of binding GO:0051100 58 36 0,000 0,19347361 0,2132196 ! organic ether metabolic process GO:0018904 46 36 0,000 0,19347361 0,21311748 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,19347361 0,21301547 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,19347361 0,21291354 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,19347361 0,21281172 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,19828152 0,21799593 ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,19828152 0,21789178 ! ion transmembrane transport GO:0034220 56 37 0,000 0,19828152 0,21778772 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,19828152 0,21768377 ! regulation of protein secretion GO:0050708 51 37 0,000 0,19828152 0,21757991 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,19828152 0,21747615 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,20306104 0,2226122 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,20306104 0,22250614 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,20306104 0,22240019 ! phagocytosis GO:0006909 60 38 0,000 0,20306104 0,22229433 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,20781234 0,22738743 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,20781234 0,2272793 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,20781234 0,22717128 ! chromatin remodeling GO:0006338 68 39 0,000 0,20781234 0,22706336 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,20781234 0,22695554 ! JNK cascade GO:0007254 54 39 0,000 0,20781234 0,22684783 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,21253558 0,23189366 ! response to calcium ion GO:0051592 58 40 0,000 0,21253558 0,2317837 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,21253558 0,23167385 ! regulation of tube size GO:0035150 60 40 0,000 0,21253558 0,23156411 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,21253558 0,23145447 ! peptide metabolic process GO:0006518 56 40 0,000 0,21253558 0,23134493 ! inner ear development GO:0048839 57 40 0,000 0,21253558 0,23123549 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,21253558 0,23112616 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,21253558 0,23101693 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,21253558 0,23090781 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,21723093 0,23589761 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,21723093 0,23578629 ! endosome transport GO:0016197 71 41 0,000 0,21723093 0,23567507 ! striated muscle contraction GO:0006941 62 41 0,000 0,21723093 0,23556395 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,21723093 0,23545294 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,21723093 0,23534203 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,21723093 0,23523123 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,22189855 0,24017255 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,22189855 0,24005958 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,22189855 0,23994672 ! excretion GO:0007588 63 42 0,000 0,22189855 0,23983396 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,22189855 0,23972131 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,22189855 0,23960876 ! positive regulation of binding GO:0051099 59 43 0,000 0,22653861 0,24450436 ! neuromuscular process GO:0050905 79 43 0,000 0,22653861 0,24438968 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,22653861 0,2442751 ! tRNA processing GO:0008033 49 43 0,000 0,22653861 0,24416063 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,22653861 0,24404627 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,23115125 0,24889882 ! glycolysis GO:0006096 53 44 0,000 0,23115125 0,24878235 ! regulation of ion transport GO:0043269 57 44 0,000 0,23115125 0,24866599 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,23115125 0,24854974 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,23115125 0,24843359 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,23115125 0,24831756 ! RNA catabolic process GO:0006401 64 45 0,000 0,23573666 0,25312526 ! regulation of translational initiation GO:0006446 64 45 0,000 0,23573666 0,25300715 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,23573666 0,25288914 ! cell maturation GO:0048469 60 45 0,000 0,23573666 0,25277124 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,24029498 0,25753888 ! cell redox homeostasis GO:0045454 63 46 0,000 0,24029498 0,25741893 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,24029498 0,25729909 ! histone modification GO:0016570 68 46 0,000 0,24029498 0,25717936 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,24029498 0,25705974 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,24482637 0,26178551 ! viral infectious cycle GO:0019058 71 47 0,000 0,24482637 0,26166387 ! endocrine system development GO:0035270 83 47 0,000 0,24482637 0,26154233 ! covalent chromatin modification GO:0016569 75 47 0,000 0,24482637 0,26142091 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,24482637 0,2612996 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,24482637 0,26117841 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,24482637 0,26105732 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,24482637 0,26093635 ! chloride transport GO:0006821 67 48 0,000 0,24933099 0,2656143 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,24933099 0,26549133 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,24933099 0,26536847 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,24933099 0,26524573 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,24933099 0,2651231 ! regulation of endocytosis GO:0030100 63 48 0,000 0,24933099 0,26500059 ! nuclear export GO:0051168 69 48 0,000 0,24933099 0,26487818 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,24933099 0,2647559 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,25380899 0,26938656 ! sensory perception of smell GO:0007608 61 49 0,000 0,25380899 0,26926231 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,25380899 0,26913817 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,25380899 0,26901414 ! RNA elongation GO:0006354 62 49 0,000 0,25380899 0,26889023 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,25380899 0,26876643 ! regulation of actin filament length GO:0030832 72 50 0,000 0,25826054 0,27335446 ! membrane fusion GO:0006944 80 50 0,000 0,25826054 0,27322873 ! proton transport GO:0015992 75 50 0,000 0,25826054 0,2731031 ! positive regulation of secretion GO:0051047 71 51 0,000 0,26268579 0,27765502 ! hydrogen transport GO:0006818 77 51 0,000 0,26268579 0,27752748 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,26268579 0,27740005 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,26268579 0,27727275 ! adult behavior GO:0030534 80 51 0,000 0,26268579 0,27714556 ! transition metal ion transport GO:0000041 74 52 0,000 0,26708489 0,28165761 ! regulation of cellular component size GO:0032535 74 52 0,000 0,26708489 0,28152853 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,26708489 0,28139956 ! establishment of organelle localization GO:0051656 85 52 0,000 0,26708489 0,28127072 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,27145799 0,28574525 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,27145799 0,28561454 ! single fertilization GO:0007338 59 53 0,000 0,27145799 0,28548394 ! cell projection assembly GO:0030031 76 53 0,000 0,27145799 0,28535346 ! amino acid transport GO:0006865 84 54 0,000 0,27580525 0,28979081 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,27580525 0,28965848 ! regulation of mitosis GO:0007088 84 54 0,000 0,27580525 0,28952628 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,27580525 0,28939419 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,27580525 0,28926223 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,27580525 0,28913039 ! exocytosis GO:0006887 74 55 0,000 0,28012682 0,29352696 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,28012682 0,29339329 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,28012682 0,29325975 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,28442284 0,29762172 ! chromosome segregation GO:0007059 83 57 0,000 0,28869347 0,30195315 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,28869347 0,3018159 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,28869347 0,30167877 ! developmental maturation GO:0021700 75 57 0,000 0,28869347 0,30154177 ! viral reproductive process GO:0022415 87 58 0,000 0,29293886 0,30583721 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,29293886 0,30569845 ! activation of MAPK activity GO:0000187 84 59 0,000 0,29715915 0,30996193 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,29715915 0,30982142 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,29715915 0,30968104 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,30135449 0,31391093 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,30135449 0,31376882 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,30135449 0,31362685 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,30135449 0,313485 ! fertilization GO:0009566 68 60 0,000 0,30135449 0,31334328 ! meiosis GO:0007126 96 61 0,000 0,30552503 0,31753618 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,30552503 0,31739276 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,30552503 0,31724947 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,30552503 0,31710631 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,30967091 0,32126437 ! neurotransmitter transport GO:0006836 81 62 0,000 0,30967091 0,32111952 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,30967091 0,32097481 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,30967091 0,32083022 ! meiotic cell cycle GO:0051321 97 62 0,000 0,30967091 0,32068577 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,31379228 0,32480749 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,31379228 0,32466138 ! viral reproduction GO:0016032 92 63 0,000 0,31379228 0,3245154 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,31788928 0,32860465 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,31788928 0,32845703 ! hexose catabolic process GO:0019320 82 64 0,000 0,31788928 0,32830954 ! defense response to bacterium GO:0042742 73 65 0,000 0,32196205 0,33236657 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,32196205 0,33221746 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,32601073 0,33624425 ! antigen processing and presentation GO:0019882 96 66 0,000 0,32601073 0,33609354 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,32601073 0,33594296 ! regulation of immune effector process GO:0002697 101 66 0,000 0,32601073 0,33579252 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,33003547 0,33978585 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,33403641 0,34375112 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,33403641 0,34359738 ! inorganic anion transport GO:0015698 93 68 0,000 0,33403641 0,34344378 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,33801368 0,34737778 ! amine transport GO:0015837 101 70 0,000 0,34196743 0,35128409 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,34196743 0,35112727 ! regulation of catabolic process GO:0009894 106 70 0,000 0,34196743 0,35097059 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,34589779 0,35484608 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,34589779 0,35468788 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,34589779 0,35452982 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,35368888 0,36235387 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,3575499 0,36614638 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,3575499 0,36598343 ! blood coagulation GO:0007596 116 75 0,000 0,36138806 0,36974757 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,36138806 0,36958317 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,3689964 0,37719632 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,3689964 0,37702875 ! regulation of DNA binding GO:0051101 119 77 0,000 0,3689964 0,37686133 ! protein ubiquitination GO:0016567 125 77 0,000 0,3689964 0,37669406 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,3689964 0,37652694 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,37276683 0,38020564 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,37276683 0,3800371 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,37651495 0,38368825 ! cellular respiration GO:0045333 107 79 0,000 0,37651495 0,38351833 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,37651495 0,38334855 ! regulation of lyase activity GO:0051339 133 79 0,000 0,37651495 0,38317893 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,37651495 0,38300946 ! chromatin assembly GO:0031497 102 80 0,000 0,38024088 0,38662866 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,38024088 0,38645781 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,38024088 0,38628712 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,38394476 0,38987769 ! hemostasis GO:0007599 125 81 0,000 0,38394476 0,38970563 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,38394476 0,38953373 ! vitamin metabolic process GO:0006766 103 81 0,000 0,38394476 0,38936197 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,38394476 0,38919037 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,39128688 0,39645808 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,39492538 0,39996846 ! sterol metabolic process GO:0016125 120 84 0,000 0,39492538 0,39979242 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,39854233 0,40327645 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,40213787 0,40673575 ! nucleosome organization GO:0034728 114 87 0,000 0,40571212 0,4101705 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,40571212 0,40999028 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,40926521 0,4133992 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,40926521 0,41321773 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,41279725 0,416601 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,41279725 0,41641828 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,41630838 0,4197761 ! hormone metabolic process GO:0042445 121 90 0,000 0,41630838 0,41959215 ! ATP metabolic process GO:0046034 137 91 0,000 0,41979872 0,42292469 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,42326839 0,42623349 ! DNA recombination GO:0006310 146 92 0,000 0,42326839 0,42604695 ! sulfur metabolic process GO:0006790 118 92 0,000 0,42326839 0,42586058 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,4267175 0,42914309 ! electron transport chain GO:0022900 123 94 0,000 0,43014618 0,43240219 ! carboxylic acid transport GO:0046942 147 95 0,000 0,43355456 0,43563804 GO:0015849|organic acid transport, ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,43694274 0,43885079 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,43694274 0,43865923 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,44031085 0,44184771 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,44031085 0,44165502 ! calcium ion transport GO:0006816 167 99 0,000 0,44698732 0,44815642 ! regulation of translation GO:0006417 151 100 0,000 0,45029592 0,45127695 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,45029592 0,4510804 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,45029592 0,45088403 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,45029592 0,45068782 ! divalent metal ion transport GO:0070838 171 100 0,000 0,45029592 0,45049178 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,45029592 0,45029592