pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6389-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! branching morphogenesis of a tube GO:0048754 97 45 6,000 1,427E-09 3,435E-06 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 4,000 3,637E-09 4,375E-06 GO:0060675|ureteric bud morphogenesis, ! morphogenesis of a branching structure GO:0001763 111 52 6,000 4,098E-09 3,286E-06 ! tube morphogenesis GO:0035239 176 86 7,000 6,22E-09 3,741E-06 ! ureteric bud development GO:0001657 43 22 4,000 4,645E-08 2,235E-05 ! induction of positive chemotaxis GO:0050930 15 9 3,000 5,223E-08 2,095E-05 ! epithelial tube morphogenesis GO:0060562 98 51 5,000 1,261E-07 4,335E-05 ! cartilage development GO:0051216 90 52 5,000 1,42E-07 4,272E-05 ! regulation of positive chemotaxis GO:0050926 19 12 3,000 2,03E-07 5,427E-05 GO:0050927|positive regulation of positive chemotaxis, ! regulation of bone remodeling GO:0046850 137 57 5,000 2,485E-07 5,978E-05 ! regulation of tissue remodeling GO:0034103 140 58 5,000 2,761E-07 6,039E-05 ! metanephros development GO:0001656 74 32 4,000 3,424E-07 6,864E-05 ! hair follicle morphogenesis GO:0031069 26 14 3,000 4,076E-07 7,544E-05 ! release of cytochrome c from mitochondria GO:0001836 30 14 3,000 4,076E-07 7,005E-05 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 2,000 9,35E-07 1,5E-04 ! neutrophil chemotaxis GO:0030593 27 17 3,000 9,589E-07 1,442E-04 ! epidermis morphogenesis GO:0048730 40 18 3,000 1,228E-06 1,739E-04 ! regulation of epithelial cell proliferation GO:0050678 111 43 4,000 1,572E-06 2,101E-04 ! positive regulation of ossification GO:0045778 47 20 3,000 1,931E-06 2,446E-04 ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 1,931E-06 2,323E-04 ! induction of apoptosis by intracellular signals GO:0008629 93 45 4,000 1,98E-06 2,269E-04 ! cell aging GO:0007569 44 21 3,000 2,377E-06 2,6E-04 ! positive regulation of locomotion GO:0040017 39 21 3,000 2,377E-06 2,487E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of bone remodeling GO:0046852 51 22 3,000 2,895E-06 2,902E-04 GO:0034105|positive regulation of tissue remodeling, ! regulation of chemotaxis GO:0050920 40 22 3,000 2,895E-06 2,786E-04 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 2,000 3,251E-06 3,008E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 2,000 3,251E-06 2,897E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 3,251E-06 2,793E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 3,251E-06 2,697E-04 ! gland development GO:0048732 206 88 5,000 3,303E-06 2,649E-04 ! regulation of ossification GO:0030278 117 50 4,000 3,371E-06 2,617E-04 ! protein import into nucleus, translocation GO:0000060 46 24 3,000 4,176E-06 3,14E-04 ! regulation of behavior GO:0050795 43 24 3,000 4,176E-06 3,045E-04 ! regulation of neuron apoptosis GO:0043523 100 53 4,000 4,516E-06 3,196E-04 ! ER overload response GO:0006983 12 8 2,000 5,184E-06 3,563E-04 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 5,184E-06 3,464E-04 ! molting cycle process GO:0022404 50 26 3,000 5,833E-06 3,793E-04 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! positive regulation of cell migration GO:0030335 126 57 4,000 6,493E-06 4,111E-04 ! skeletal system morphogenesis GO:0048705 105 59 4,000 7,707E-06 4,755E-04 ! kidney development GO:0001822 122 60 4,000 8,377E-06 5,039E-04 ! lung alveolus development GO:0048286 26 10 2,000 1,103E-05 6,475E-04 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 2,000 1,103E-05 6,32E-04 ! positive regulation of cell motion GO:0051272 146 64 4,000 1,152E-05 6,448E-04 ! chondrocyte differentiation GO:0002062 24 11 2,000 1,512E-05 8,268E-04 ! negative regulation of glucose import GO:0046325 17 11 2,000 1,512E-05 8,084E-04 GO:0010829|negative regulation of glucose transport, ! leukocyte chemotaxis GO:0030595 50 33 3,000 1,557E-05 8,146E-04 GO:0060326|cell chemotaxis, ! urogenital system development GO:0001655 137 69 4,000 1,668E-05 8,538E-04 ! focal adhesion formation GO:0048041 35 12 2,000 2,009E-05 1,007E-03 ! gland morphogenesis GO:0022612 29 12 2,000 2,009E-05 9,865E-04 ! digestive tract morphogenesis GO:0048546 26 12 2,000 2,009E-05 9,668E-04 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! positive regulation of cell development GO:0010720 80 36 3,000 2,218E-05 1,046E-03 ! cell-matrix adhesion GO:0007160 163 75 4,000 2,505E-05 1,159E-03 ! mammary gland development GO:0030879 86 39 3,000 3,064E-05 1,391E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 2,000 3,302E-05 1,471E-03 ! response to gamma radiation GO:0010332 28 14 2,000 3,302E-05 1,444E-03 ! positive regulation of bone mineralization GO:0030501 29 14 2,000 3,302E-05 1,419E-03 ! mesenchymal cell development GO:0014031 87 40 3,000 3,393E-05 1,432E-03 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! protein import into nucleus GO:0006606 158 80 4,000 3,426E-05 1,421E-03 ! cell-substrate adhesion GO:0031589 171 81 4,000 3,638E-05 1,484E-03 ! nuclear import GO:0051170 161 81 4,000 3,638E-05 1,459E-03 ! response to drug GO:0042493 143 82 4,000 3,861E-05 1,523E-03 ! negative regulation of bone remodeling GO:0046851 33 15 2,000 4,114E-05 1,596E-03 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 4,114E-05 1,571E-03 ! positive regulation of biomineral formation GO:0070169 30 15 2,000 4,114E-05 1,546E-03 ! epithelial to mesenchymal transition GO:0001837 28 15 2,000 4,114E-05 1,523E-03 ! negative regulation of growth GO:0045926 155 84 4,000 4,336E-05 1,581E-03 ! positive regulation of response to external stimulus GO:0032103 77 43 3,000 4,533E-05 1,628E-03 ! complement activation, alternative pathway GO:0006957 18 16 2,000 5,046E-05 1,785E-03 ! negative regulation of tissue remodeling GO:0034104 36 16 2,000 5,046E-05 1,76E-03 ! positive regulation of neuron apoptosis GO:0043525 32 16 2,000 5,046E-05 1,734E-03 ! protein localization in nucleus GO:0034504 176 87 4,000 5,133E-05 1,739E-03 ! leukocyte migration GO:0050900 68 45 3,000 5,434E-05 1,816E-03 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 3,000 5,931E-05 1,955E-03 ! negative regulation of homeostatic process GO:0032845 33 17 2,000 6,107E-05 1,985E-03 ! negative regulation of multicellular organismal process GO:0051241 166 93 4,000 7,063E-05 2,266E-03 ! patterning of blood vessels GO:0001569 39 18 2,000 7,303E-05 2,312E-03 ! cell-substrate junction assembly GO:0007044 54 18 2,000 7,303E-05 2,282E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 7,303E-05 2,253E-03 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 2,000 8,644E-05 2,633E-03 ! proximal/distal pattern formation GO:0009954 32 19 2,000 8,644E-05 2,6E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 2,000 1,014E-04 3,01E-03 ! response to alkaloid GO:0043279 38 20 2,000 1,014E-04 2,974E-03 ! cellular response to starvation GO:0009267 33 20 2,000 1,014E-04 2,938E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 1,014E-04 2,903E-03 ! regulation of glucose import GO:0046324 29 20 2,000 1,014E-04 2,869E-03 GO:0010827|regulation of glucose transport, ! response to UV GO:0009411 104 53 3,000 1,038E-04 2,904E-03 ! inactivation of MAPK activity GO:0000188 39 21 2,000 1,178E-04 3,259E-03 ! collagen fibril organization GO:0030199 59 21 2,000 1,178E-04 3,222E-03 ! positive regulation of inflammatory response GO:0050729 35 21 2,000 1,178E-04 3,186E-03 ! positive regulation of osteoblast differentiation GO:0045669 49 21 2,000 1,178E-04 3,15E-03 ! gut development GO:0048565 39 21 2,000 1,178E-04 3,116E-03 ! aging GO:0007568 103 55 3,000 1,201E-04 3,14E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 1,36E-04 3,518E-03 ! positive regulation of intracellular transport GO:0032388 37 22 2,000 1,36E-04 3,481E-03 ! positive regulation of cell adhesion GO:0045785 56 23 2,000 1,559E-04 3,948E-03 ! activation of pro-apoptotic gene products GO:0008633 47 23 2,000 1,559E-04 3,907E-03 ! regulation of bone mineralization GO:0030500 49 23 2,000 1,559E-04 3,866E-03 ! regulation of heart contraction GO:0008016 110 60 3,000 1,686E-04 4,14E-03 ! negative regulation of response to stimulus GO:0048585 100 60 3,000 1,686E-04 4,099E-03 ! negative regulation of phosphorylation GO:0042326 47 24 2,000 1,775E-04 4,272E-03 ! response to peptide hormone stimulus GO:0043434 122 61 3,000 1,798E-04 4,284E-03 ! regulation of homeostatic process GO:0032844 134 62 3,000 1,916E-04 4,519E-03 ! response to starvation GO:0042594 42 25 2,000 2,011E-04 4,697E-03 ! response to endoplasmic reticulum stress GO:0034976 43 25 2,000 2,011E-04 4,652E-03 ! negative regulation of cell development GO:0010721 73 25 2,000 2,011E-04 4,608E-03 GO:0050768|negative regulation of neurogenesis, ! regulation of biomineral formation GO:0070167 51 25 2,000 2,011E-04 4,564E-03 ! cellular response to nutrient levels GO:0031669 41 25 2,000 2,011E-04 4,521E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 2,066E-04 4,602E-03 ! negative regulation of survival gene product expression GO:0008634 8 5 1,000 2,066E-04 4,56E-03 ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 2,066E-04 4,518E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 2,066E-04 4,478E-03 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 2,066E-04 4,438E-03 ! muscle cell proliferation GO:0033002 11 5 1,000 2,066E-04 4,398E-03 ! B cell homeostasis GO:0001782 13 5 1,000 2,066E-04 4,36E-03 ! regulation of hair follicle development GO:0051797 10 5 1,000 2,066E-04 4,322E-03 GO:0042634|regulation of hair cycle, ! glial cell migration GO:0008347 11 5 1,000 2,066E-04 4,285E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 2,066E-04 4,248E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 2,066E-04 4,212E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 2,066E-04 4,176E-03 ! stem cell division GO:0017145 11 5 1,000 2,066E-04 4,142E-03 GO:0048103|somatic stem cell division, ! odontogenesis of dentine-containing tooth GO:0042475 48 26 2,000 2,265E-04 4,505E-03 ! insulin receptor signaling pathway GO:0008286 64 26 2,000 2,265E-04 4,468E-03 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 2,000 2,265E-04 4,431E-03 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of osteoblast differentiation GO:0045667 65 26 2,000 2,265E-04 4,396E-03 ! embryonic limb morphogenesis GO:0030326 125 65 3,000 2,3E-04 4,428E-03 GO:0035113|embryonic appendage morphogenesis, ! extracellular matrix organization GO:0030198 133 66 3,000 2,44E-04 4,66E-03 ! mitochondrial membrane organization GO:0007006 57 27 2,000 2,54E-04 4,812E-03 ! negative regulation of protein kinase activity GO:0006469 130 67 3,000 2,586E-04 4,861E-03 ! negative regulation of cell growth GO:0030308 132 67 3,000 2,586E-04 4,823E-03 ! lung development GO:0030324 144 67 3,000 2,586E-04 4,786E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 3,000 2,586E-04 4,749E-03 ! negative regulation of kinase activity GO:0033673 131 68 3,000 2,738E-04 4,99E-03 ! dendrite development GO:0016358 59 28 2,000 2,835E-04 5,129E-03 ! negative regulation of protein modification process GO:0031400 60 28 2,000 2,835E-04 5,091E-03 ! ER-nuclear signaling pathway GO:0006984 48 28 2,000 2,835E-04 5,053E-03 ! negative regulation of cell size GO:0045792 134 69 3,000 2,896E-04 5,123E-03 ! appendage morphogenesis GO:0035107 135 70 3,000 3,061E-04 5,375E-03 GO:0035108|limb morphogenesis, ! respiratory tube development GO:0030323 150 70 3,000 3,061E-04 5,336E-03 ! forebrain regionalization GO:0021871 8 6 1,000 3,089E-04 5,347E-03 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 1,000 3,089E-04 5,309E-03 ! activation of MAPKKK activity GO:0000185 12 6 1,000 3,089E-04 5,271E-03 ! neural nucleus development GO:0048857 14 6 1,000 3,089E-04 5,234E-03 ! interaction with symbiont GO:0051702 13 6 1,000 3,089E-04 5,198E-03 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 3,089E-04 5,162E-03 ! negative regulation of multicellular organism growth GO:0040015 8 6 1,000 3,089E-04 5,126E-03 ! salivary gland morphogenesis GO:0007435 13 6 1,000 3,089E-04 5,091E-03 ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 3,089E-04 5,056E-03 ! negative regulation of axon extension GO:0030517 21 6 1,000 3,089E-04 5,022E-03 ! ectodermal gut morphogenesis GO:0048567 12 6 1,000 3,089E-04 4,988E-03 GO:0007439|ectodermal gut development, ! cellular response to extracellular stimulus GO:0031668 48 29 2,000 3,152E-04 5,056E-03 ! negative regulation of neuron apoptosis GO:0043524 56 29 2,000 3,152E-04 5,022E-03 ! appendage development GO:0048736 136 71 3,000 3,232E-04 5,116E-03 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 3,000 3,232E-04 5,082E-03 ! negative regulation of transferase activity GO:0051348 140 72 3,000 3,41E-04 5,328E-03 ! respiratory system development GO:0060541 153 72 3,000 3,41E-04 5,293E-03 ! cell junction assembly GO:0034329 78 30 2,000 3,49E-04 5,383E-03 ! response to ionizing radiation GO:0010212 65 32 2,000 4,236E-04 6,491E-03 ! negative regulation of MAP kinase activity GO:0043407 69 32 2,000 4,236E-04 6,45E-03 ! BMP signaling pathway GO:0030509 64 32 2,000 4,236E-04 6,41E-03 ! regulation of helicase activity GO:0051095 15 7 1,000 4,312E-04 6,484E-03 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 4,312E-04 6,444E-03 ! mRNA stabilization GO:0048255 18 7 1,000 4,312E-04 6,404E-03 GO:0043489|RNA stabilization, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 1,000 4,312E-04 6,365E-03 ! spinal cord patterning GO:0021511 13 7 1,000 4,312E-04 6,326E-03 ! organ growth GO:0035265 15 7 1,000 4,312E-04 6,288E-03 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 4,312E-04 6,25E-03 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 1,000 4,312E-04 6,212E-03 ! cranial nerve morphogenesis GO:0021602 11 7 1,000 4,312E-04 6,175E-03 ! response to tumor cell GO:0002347 13 7 1,000 4,312E-04 6,139E-03 ! axonal fasciculation GO:0007413 18 7 1,000 4,312E-04 6,103E-03 ! peptidyl-threonine modification GO:0018210 25 7 1,000 4,312E-04 6,067E-03 ! dopamine biosynthetic process GO:0042416 18 7 1,000 4,312E-04 6,032E-03 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 4,312E-04 5,997E-03 ! DNA damage checkpoint GO:0000077 71 33 2,000 4,644E-04 6,421E-03 ! post-embryonic development GO:0009791 69 33 2,000 4,644E-04 6,384E-03 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 3,000 4,858E-04 6,642E-03 ! positive regulation of phosphorylation GO:0042327 129 79 3,000 4,858E-04 6,604E-03 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 3,000 5,342E-04 7,221E-03 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 171 81 3,000 5,342E-04 7,18E-03 ! odontogenesis GO:0042476 66 35 2,000 5,533E-04 7,396E-03 ! embryonic skeletal system morphogenesis GO:0048704 59 35 2,000 5,533E-04 7,356E-03 ! negative regulation of hydrolase activity GO:0051346 62 35 2,000 5,533E-04 7,315E-03 ! response to nutrient GO:0007584 125 82 3,000 5,596E-04 7,358E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 1,000 5,732E-04 7,495E-03 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 1,000 5,732E-04 7,455E-03 ! T-helper 1 type immune response GO:0042088 12 8 1,000 5,732E-04 7,414E-03 ! pigment granule organization GO:0048753 16 8 1,000 5,732E-04 7,375E-03 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 5,732E-04 7,336E-03 ! regulation of pigmentation during development GO:0048070 24 8 1,000 5,732E-04 7,297E-03 ! melanin metabolic process GO:0006582 15 8 1,000 5,732E-04 7,258E-03 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 5,732E-04 7,22E-03 ! regulation of vascular permeability GO:0043114 12 8 1,000 5,732E-04 7,183E-03 ! response to UV-B GO:0010224 16 8 1,000 5,732E-04 7,146E-03 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 1,000 5,732E-04 7,109E-03 ! positive regulation of epidermis development GO:0045684 13 8 1,000 5,732E-04 7,072E-03 ! regulation of Rac protein signal transduction GO:0035020 11 8 1,000 5,732E-04 7,036E-03 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 1,000 5,732E-04 7E-03 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 5,732E-04 6,965E-03 ! response to oxygen levels GO:0070482 176 83 3,000 5,859E-04 7,084E-03 ! cell junction organization GO:0034330 86 36 2,000 6,016E-04 7,238E-03 ! DNA integrity checkpoint GO:0031570 75 36 2,000 6,016E-04 7,202E-03 ! cellular response to insulin stimulus GO:0032869 82 37 2,000 6,525E-04 7,772E-03 ! mitochondrion organization GO:0007005 148 86 3,000 6,699E-04 7,94E-03 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 2,000 7,061E-04 8,328E-03 GO:0006956|complement activation, ! mitotic cell cycle checkpoint GO:0007093 76 38 2,000 7,061E-04 8,287E-03 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 2,000 7,061E-04 8,247E-03 ! keratinocyte proliferation GO:0043616 14 9 1,000 7,347E-04 8,54E-03 ! microtubule bundle formation GO:0001578 21 9 1,000 7,347E-04 8,499E-03 ! middle ear morphogenesis GO:0042474 14 9 1,000 7,347E-04 8,458E-03 ! T cell selection GO:0045058 23 9 1,000 7,347E-04 8,418E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 1,000 7,347E-04 8,378E-03 ! behavioral fear response GO:0001662 22 9 1,000 7,347E-04 8,339E-03 GO:0002209|behavioral defense response, ! motor axon guidance GO:0008045 16 9 1,000 7,347E-04 8,3E-03 ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 7,347E-04 8,261E-03 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 7,347E-04 8,222E-03 ! spinal cord motor neuron differentiation GO:0021522 15 9 1,000 7,347E-04 8,184E-03 ! regulation of telomere maintenance GO:0032204 14 9 1,000 7,347E-04 8,147E-03 ! mitochondrion localization GO:0051646 15 9 1,000 7,347E-04 8,109E-03 ! regulation of cell morphogenesis GO:0022604 215 89 3,000 7,621E-04 8,373E-03 ! regulation of cell adhesion GO:0030155 212 89 3,000 7,621E-04 8,335E-03 ! response to protein stimulus GO:0051789 149 91 3,000 8,284E-04 9,019E-03 ! T cell differentiation GO:0030217 81 41 2,000 8,833E-04 9,574E-03 ! dorsal/ventral pattern formation GO:0009953 68 41 2,000 8,833E-04 9,531E-03 ! negative regulation of blood pressure GO:0045776 26 10 1,000 9,157E-04 9,835E-03 ! regulation of phosphatase activity GO:0010921 28 10 1,000 9,157E-04 9,792E-03 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 1,000 9,157E-04 9,748E-03 ! SMAD protein nuclear translocation GO:0007184 20 10 1,000 9,157E-04 9,705E-03 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 9,157E-04 9,663E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 1,000 9,157E-04 9,621E-03 ! smoothened signaling pathway GO:0007224 16 10 1,000 9,157E-04 9,579E-03 ! positive regulation of heart contraction GO:0045823 16 10 1,000 9,157E-04 9,537E-03 ! B cell proliferation GO:0042100 18 10 1,000 9,157E-04 9,496E-03 ! regulation of smoothened signaling pathway GO:0008589 23 10 1,000 9,157E-04 9,455E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 9,157E-04 9,415E-03 ! regulation of bone resorption GO:0045124 25 10 1,000 9,157E-04 9,375E-03 ! regulation of gliogenesis GO:0014013 23 10 1,000 9,157E-04 9,335E-03 GO:0045685|regulation of glial cell differentiation, ! alpha-beta T cell activation GO:0046631 23 10 1,000 9,157E-04 9,296E-03 ! negative regulation of axonogenesis GO:0050771 32 10 1,000 9,157E-04 9,257E-03 ! salivary gland development GO:0007431 27 10 1,000 9,157E-04 9,218E-03 ! positive regulation of leukocyte migration GO:0002687 25 10 1,000 9,157E-04 9,18E-03 ! negative regulation of BMP signaling pathway GO:0030514 19 10 1,000 9,157E-04 9,142E-03 ! oocyte development GO:0048599 17 10 1,000 9,157E-04 9,104E-03 ! response to nicotine GO:0035094 20 10 1,000 9,157E-04 9,066E-03 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 9,157E-04 9,029E-03 ! localization within membrane GO:0051668 20 10 1,000 9,157E-04 8,992E-03 ! response to reactive oxygen species GO:0000302 67 42 2,000 9,481E-04 9,273E-03 ! regulation of intracellular protein transport GO:0033157 80 42 2,000 9,481E-04 9,236E-03 ! interphase of mitotic cell cycle GO:0051329 209 95 3,000 9,729E-04 9,439E-03 ! positive regulation of immune response GO:0050778 156 96 3,000 1,012E-03 9,775E-03 ! neural tube development GO:0021915 77 43 2,000 1,016E-03 9,776E-03 ! regulation of protein localization GO:0032880 176 97 3,000 1,051E-03 0,01007881 ! B cell differentiation GO:0030183 107 44 2,000 1,087E-03 0,0103737 ! developmental growth GO:0048589 82 44 2,000 1,087E-03 0,01033269 ! interphase GO:0051325 213 98 3,000 1,092E-03 0,01034706 ! neuron fate specification GO:0048665 17 11 1,000 1,116E-03 0,01052786 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 1,000 1,116E-03 0,01048673 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 1,116E-03 0,01044593 ! detection of mechanical stimulus GO:0050982 22 11 1,000 1,116E-03 0,01040544 ! blood vessel remodeling GO:0001974 29 11 1,000 1,116E-03 0,01036527 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 1,000 1,116E-03 0,0103254 ! ventral spinal cord development GO:0021517 21 11 1,000 1,116E-03 0,01028584 ! regulation of intracellular pH GO:0051453 19 11 1,000 1,116E-03 0,01024658 ! negative regulation of ossification GO:0030279 26 11 1,000 1,116E-03 0,01020762 ! DNA methylation GO:0006306 19 11 1,000 1,116E-03 0,01016895 GO:0006305|DNA alkylation, ! regulation of leukocyte migration GO:0002685 26 11 1,000 1,116E-03 0,01013058 ! oocyte differentiation GO:0009994 18 11 1,000 1,116E-03 0,0100925 ! thymus development GO:0048538 27 11 1,000 1,116E-03 0,0100547 ! embryonic gut development GO:0048566 15 11 1,000 1,116E-03 0,01001718 ! cardiac cell differentiation GO:0035051 31 11 1,000 1,116E-03 9,98E-03 ! cell cycle arrest GO:0007050 213 100 3,000 1,177E-03 0,01049221 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 2,000 1,237E-03 0,01098289 ! regulation of gene-specific transcription GO:0032583 96 46 2,000 1,237E-03 0,01094251 ! pigmentation GO:0043473 100 46 2,000 1,237E-03 0,01090243 ! response to insulin stimulus GO:0032868 95 46 2,000 1,237E-03 0,01086264 ! positive regulation of protein transport GO:0051222 72 46 2,000 1,237E-03 0,01082314 ! positive regulation of defense response GO:0031349 76 47 2,000 1,317E-03 0,0114808 ! negative regulation of cell projection organization GO:0031345 37 12 1,000 1,335E-03 0,01159515 ! cartilage condensation GO:0001502 20 12 1,000 1,335E-03 0,01155344 ! protein complex disassembly GO:0043241 27 12 1,000 1,335E-03 0,01151203 GO:0043624|cellular protein complex disassembly, ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 1,000 1,335E-03 0,01147092 ! positive regulation of cell growth GO:0030307 22 12 1,000 1,335E-03 0,01143009 ! mitotic spindle organization GO:0007052 21 12 1,000 1,335E-03 0,01138956 ! fear response GO:0042596 26 12 1,000 1,335E-03 0,01134932 ! cranial nerve development GO:0021545 20 12 1,000 1,335E-03 0,01130935 ! T cell homeostasis GO:0043029 25 12 1,000 1,335E-03 0,01126967 ! spleen development GO:0048536 22 12 1,000 1,335E-03 0,01123027 ! negative regulation of mast cell proliferation GO:0070667 23 12 1,000 1,335E-03 0,01119114 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 1,000 1,335E-03 0,01115228 ! positive regulation of cell cycle GO:0045787 89 48 2,000 1,4E-03 0,01165635 ! mitochondrial transport GO:0006839 82 48 2,000 1,4E-03 0,01161615 ! cellular component disassembly GO:0022411 86 48 2,000 1,4E-03 0,01157624 ! activation of caspase activity GO:0006919 84 48 2,000 1,4E-03 0,01153659 ! regulation of inflammatory response GO:0050727 75 48 2,000 1,4E-03 0,01149722 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 1,486E-03 0,01216472 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 1,573E-03 0,01282862 ! response to X-ray GO:0010165 25 13 1,000 1,573E-03 0,01278528 ! exocrine system development GO:0035272 32 13 1,000 1,573E-03 0,01274223 ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 1,573E-03 0,01269947 ! regulation of cellular pH GO:0030641 22 13 1,000 1,573E-03 0,012657 ! regulation of monooxygenase activity GO:0032768 33 13 1,000 1,573E-03 0,01261481 ! regulation of epidermis development GO:0045682 19 13 1,000 1,573E-03 0,0125729 ! regulation of mRNA stability GO:0043488 31 13 1,000 1,573E-03 0,01253127 ! negative regulation of immune system process GO:0002683 95 50 2,000 1,576E-03 0,01251497 ! response to estrogen stimulus GO:0043627 93 51 2,000 1,669E-03 0,01320928 ! embryonic skeletal system development GO:0048706 85 51 2,000 1,669E-03 0,01316597 ! regulation of muscle contraction GO:0006937 81 52 2,000 1,765E-03 0,01388002 ! positive regulation of growth GO:0045927 90 52 2,000 1,765E-03 0,01383481 ! T cell differentiation in the thymus GO:0033077 31 14 1,000 1,83E-03 0,01429202 ! catecholamine biosynthetic process GO:0042423 30 14 1,000 1,83E-03 0,01424577 ! regulation of RNA stability GO:0043487 32 14 1,000 1,83E-03 0,01419981 ! regulation of axon extension GO:0030516 37 14 1,000 1,83E-03 0,01415415 ! positive regulation of caspase activity GO:0043280 95 55 2,000 2,075E-03 0,01599936 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 97 55 2,000 2,075E-03 0,01594824 ! regulation of multicellular organism growth GO:0040014 85 55 2,000 2,075E-03 0,01589745 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 2,105E-03 0,01607599 ! positive regulation of cell size GO:0045793 27 15 1,000 2,105E-03 0,01602512 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 1,000 2,105E-03 0,01597457 ! G1/S transition checkpoint GO:0031575 40 15 1,000 2,105E-03 0,01592433 ! dopamine metabolic process GO:0042417 35 15 1,000 2,105E-03 0,01587441 ! cell killing GO:0001906 29 15 1,000 2,105E-03 0,0158248 ! lymphocyte homeostasis GO:0002260 30 15 1,000 2,105E-03 0,01577551 ! regulation of intracellular transport GO:0032386 101 57 2,000 2,299E-03 0,01717515 ! activation of MAPKK activity GO:0000186 35 16 1,000 2,398E-03 0,01786382 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 2,398E-03 0,01780868 GO:0031114|regulation of microtubule depolymerization, ! regulation of dephosphorylation GO:0035303 43 16 1,000 2,398E-03 0,01775389 ! negative regulation of immune response GO:0050777 35 16 1,000 2,398E-03 0,01769943 ! positive regulation of protein import into nucleus GO:0042307 30 16 1,000 2,398E-03 0,0176453 ! neuron recognition GO:0008038 35 16 1,000 2,398E-03 0,0175915 ! negative regulation of leukocyte proliferation GO:0070664 31 16 1,000 2,398E-03 0,01753803 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 37 16 1,000 2,398E-03 0,01748489 ! integrin-mediated signaling pathway GO:0007229 135 59 2,000 2,537E-03 0,01844017 ! DNA damage response, signal transduction GO:0042770 128 60 2,000 2,662E-03 0,01928791 ! protein amino acid autophosphorylation GO:0046777 141 60 2,000 2,662E-03 0,01922999 ! metencephalon development GO:0022037 30 17 1,000 2,71E-03 0,01952023 ! regulation of viral genome replication GO:0045069 28 17 1,000 2,71E-03 0,01946196 ! cell differentiation in spinal cord GO:0021515 30 17 1,000 2,71E-03 0,01940404 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 1,000 2,71E-03 0,01934646 ! regulation of survival gene product expression GO:0045884 33 17 1,000 2,71E-03 0,01928923 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 2,71E-03 0,01923232 ! regulation of protein binding GO:0043393 33 17 1,000 2,71E-03 0,01917576 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 1,000 2,71E-03 0,01911953 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 2,71E-03 0,01906362 ! ear development GO:0043583 103 62 2,000 2,922E-03 0,0204965 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 3,039E-03 0,02125803 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 1,000 3,039E-03 0,02119641 ! regulation of BMP signaling pathway GO:0030510 32 18 1,000 3,039E-03 0,02113515 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 1,000 3,039E-03 0,02107424 ! nerve development GO:0021675 28 18 1,000 3,039E-03 0,02101369 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 1,000 3,387E-03 0,02334848 ! lipid phosphorylation GO:0046834 35 19 1,000 3,387E-03 0,02328177 ! bile acid metabolic process GO:0008206 29 19 1,000 3,387E-03 0,02321544 ! actin filament bundle formation GO:0051017 42 19 1,000 3,387E-03 0,02314949 ! neuromuscular junction development GO:0007528 34 19 1,000 3,387E-03 0,02308391 ! regulation of endothelial cell migration GO:0010594 44 19 1,000 3,387E-03 0,0230187 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 1,000 3,387E-03 0,02295386 ! visual learning GO:0008542 36 19 1,000 3,387E-03 0,02288938 ! cellular pigmentation GO:0033059 36 19 1,000 3,387E-03 0,02282527 ! embryonic organ morphogenesis GO:0048562 26 19 1,000 3,387E-03 0,02276151 ! actin filament organization GO:0007015 148 66 2,000 3,489E-03 0,02338114 ! activation of immune response GO:0002253 105 67 2,000 3,64E-03 0,02432813 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 3,752E-03 0,02500534 ! camera-type eye morphogenesis GO:0048593 42 20 1,000 3,752E-03 0,02493627 ! negative regulation of T cell activation GO:0050868 40 20 1,000 3,752E-03 0,02486757 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 1,000 3,752E-03 0,02479926 ! protein maturation by peptide bond cleavage GO:0051605 105 68 2,000 3,795E-03 0,02501903 ! cell cycle checkpoint GO:0000075 137 69 2,000 3,955E-03 0,02599825 ! ovarian follicle development GO:0001541 35 21 1,000 4,134E-03 0,02710432 ! cellular macromolecular complex disassembly GO:0034623 43 21 1,000 4,134E-03 0,02703067 ! cell structure disassembly during apoptosis GO:0006921 30 21 1,000 4,134E-03 0,02695741 ! regulation of vasoconstriction GO:0019229 39 21 1,000 4,134E-03 0,02688456 ! oogenesis GO:0048477 36 21 1,000 4,134E-03 0,02681209 ! DNA modification GO:0006304 34 21 1,000 4,134E-03 0,02674002 ! response to cytokine stimulus GO:0034097 63 21 1,000 4,134E-03 0,02666833 ! collagen catabolic process GO:0030574 28 21 1,000 4,134E-03 0,02659702 ! B cell activation GO:0042113 160 71 2,000 4,286E-03 0,02749674 ! acute inflammatory response GO:0002526 113 72 2,000 4,457E-03 0,02852107 ! regulation of caspase activity GO:0043281 122 72 2,000 4,457E-03 0,02844542 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 2,000 4,457E-03 0,02837017 ! regeneration GO:0031099 41 22 1,000 4,534E-03 0,02878442 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 4,534E-03 0,02870867 ! cellular response to reactive oxygen species GO:0034614 31 22 1,000 4,534E-03 0,02863332 ! apoptotic nuclear changes GO:0030262 32 22 1,000 4,534E-03 0,02855836 ! renal system process GO:0003014 41 22 1,000 4,534E-03 0,0284838 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 4,534E-03 0,02840962 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 1,000 4,534E-03 0,02833583 ! axon guidance GO:0007411 139 73 2,000 4,633E-03 0,02887682 ! regulation of endopeptidase activity GO:0052548 125 74 2,000 4,813E-03 0,02991971 ! eye development GO:0001654 143 74 2,000 4,813E-03 0,0298426 ! visual behavior GO:0007632 42 23 1,000 4,951E-03 0,03062354 ! regulation of cell-matrix adhesion GO:0001952 78 23 1,000 4,951E-03 0,03054502 GO:0010810|regulation of cell-substrate adhesion, ! response to ethanol GO:0045471 46 23 1,000 4,951E-03 0,0304669 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 1,000 4,951E-03 0,03038918 ! regulation of viral reproduction GO:0050792 38 23 1,000 4,951E-03 0,03031185 ! lymphocyte differentiation GO:0030098 167 75 2,000 4,996E-03 0,03051122 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 1,000 5,385E-03 0,03280173 ! spinal cord development GO:0021510 47 24 1,000 5,385E-03 0,0327189 ! multicellular organismal response to stress GO:0033555 49 24 1,000 5,385E-03 0,03263648 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 5,385E-03 0,03255448 ! lymphocyte proliferation GO:0046651 48 24 1,000 5,385E-03 0,03247289 ! regulation of oxidoreductase activity GO:0051341 46 24 1,000 5,385E-03 0,03239171 ! leukocyte homeostasis GO:0001776 44 24 1,000 5,385E-03 0,03231093 ! protein tetramerization GO:0051262 52 24 1,000 5,385E-03 0,03223056 ! response to steroid hormone stimulus GO:0048545 137 78 2,000 5,573E-03 0,03327452 ! activation of protein kinase activity GO:0032147 147 79 2,000 5,774E-03 0,03438816 ! regulation of peptidase activity GO:0052547 134 79 2,000 5,774E-03 0,03430325 ! myelination GO:0042552 45 25 1,000 5,836E-03 0,03458444 ! vasculogenesis GO:0001570 46 25 1,000 5,836E-03 0,03449947 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 1,000 5,836E-03 0,03441491 ! negative regulation of DNA replication GO:0008156 42 25 1,000 5,836E-03 0,03433076 ! interaction with host GO:0051701 62 25 1,000 5,836E-03 0,03424703 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 1,000 5,836E-03 0,0341637 ! T cell activation GO:0042110 168 81 2,000 6,189E-03 0,03614129 ! regulation of neuron differentiation GO:0045664 167 81 2,000 6,189E-03 0,03605378 ! macromolecular complex disassembly GO:0032984 53 26 1,000 6,303E-03 0,03663277 ! regulation of endothelial cell proliferation GO:0001936 57 26 1,000 6,303E-03 0,0365445 ! cellular response to oxidative stress GO:0034599 39 26 1,000 6,303E-03 0,03645665 ! response to estradiol stimulus GO:0032355 40 26 1,000 6,303E-03 0,03636923 ! positive regulation of MAPKKK cascade GO:0043410 47 26 1,000 6,303E-03 0,03628222 ! leukocyte proliferation GO:0070661 52 26 1,000 6,303E-03 0,03619563 GO:0032943|mononuclear cell proliferation, ! cellular response to hormone stimulus GO:0032870 167 82 2,000 6,403E-03 0,03667745 ! regulation of fibroblast proliferation GO:0048145 52 27 1,000 6,787E-03 0,03878944 ! neuron fate commitment GO:0048663 48 27 1,000 6,787E-03 0,03869752 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 6,787E-03 0,03860604 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 1,000 6,787E-03 0,03851498 ! multicellular organismal catabolic process GO:0044243 36 27 1,000 6,787E-03 0,03842436 ! male gonad development GO:0008584 44 27 1,000 6,787E-03 0,03833416 ! response to toxin GO:0009636 47 27 1,000 6,787E-03 0,03824439 ! base-excision repair GO:0006284 41 27 1,000 6,787E-03 0,03815503 ! regulation of chromosome organization GO:0033044 42 27 1,000 6,787E-03 0,03806609 ! negative regulation of lymphocyte activation GO:0051250 53 27 1,000 6,787E-03 0,03797757 ! negative regulation of transport GO:0051051 153 84 2,000 6,843E-03 0,03820114 ! response to unfolded protein GO:0006986 131 85 2,000 7,07E-03 0,03937646 ! regulation of systemic arterial blood pressure GO:0003073 54 28 1,000 7,288E-03 0,04049436 ! regulation of protein transport GO:0051223 154 87 2,000 7,537E-03 0,04178454 GO:0070201|regulation of establishment of protein localization, ! positive regulation of protein modification process GO:0031401 136 88 2,000 7,777E-03 0,04301725 ! regulation of pH GO:0006885 43 29 1,000 7,804E-03 0,04306583 ! cellular iron ion homeostasis GO:0006879 51 29 1,000 7,804E-03 0,04296728 ! catechol metabolic process GO:0009712 54 29 1,000 7,804E-03 0,04286918 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! response to organic cyclic substance GO:0014070 55 29 1,000 7,804E-03 0,04277153 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 1,000 7,804E-03 0,04267432 ! tissue homeostasis GO:0001894 48 29 1,000 7,804E-03 0,04257755 GO:0048871|multicellular organismal homeostasis, ! ossification GO:0001503 188 90 2,000 8,271E-03 0,04502471 ! phenol metabolic process GO:0018958 55 30 1,000 8,337E-03 0,04527745 ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 8,337E-03 0,04517547 ! ensheathment of neurons GO:0007272 57 30 1,000 8,337E-03 0,04507395 GO:0008366|axon ensheathment, ! negative regulation of leukocyte activation GO:0002695 56 30 1,000 8,337E-03 0,04497289 ! eye morphogenesis GO:0048592 60 30 1,000 8,337E-03 0,04487228 ! response to heat GO:0009408 50 30 1,000 8,337E-03 0,04477212 ! bone development GO:0060348 189 91 2,000 8,525E-03 0,04568244 ! regulation of defense response GO:0031347 149 92 2,000 8,783E-03 0,04696182 ! collagen metabolic process GO:0032963 45 31 1,000 8,885E-03 0,04739979 ! cholesterol homeostasis GO:0042632 53 31 1,000 8,885E-03 0,04729492 GO:0055092|sterol homeostasis, ! ovulation cycle process GO:0022602 49 31 1,000 8,885E-03 0,04719052 ! iron ion homeostasis GO:0055072 54 31 1,000 8,885E-03 0,04708657 ! mesoderm formation GO:0001707 69 31 1,000 8,885E-03 0,04698309 ! positive regulation of MAP kinase activity GO:0043406 160 93 2,000 9,046E-03 0,04773066 ! regulation of membrane potential GO:0042391 164 93 2,000 9,046E-03 0,04762621 ! response to hydrogen peroxide GO:0042542 50 32 1,000 9,449E-03 0,04963868 ! spindle organization GO:0007051 46 32 1,000 9,449E-03 0,04953054 ! response to mechanical stimulus GO:0009612 57 32 1,000 9,449E-03 0,04942286 ! regulation of axonogenesis GO:0050770 75 32 1,000 9,449E-03 0,04931565 ! regulation of protein import into nucleus GO:0042306 63 32 1,000 9,449E-03 0,04920891 ! ovulation cycle GO:0042698 51 32 1,000 9,449E-03 0,04910263 ! peripheral nervous system development GO:0007422 64 32 1,000 9,449E-03 0,0489968 ! hindbrain development GO:0030902 61 32 1,000 9,449E-03 0,04889143 ! leukocyte differentiation GO:0002521 202 96 2,000 9,862E-03 0,05091923 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,01002875 0,05166847 ! positive regulation of neurogenesis GO:0050769 67 33 1,000 0,01002875 0,05155807 ! formation of primary germ layer GO:0001704 72 33 1,000 0,01002875 0,05144814 ! cell fate specification GO:0001708 52 33 1,000 0,01002875 0,05133867 ! regulation of DNA metabolic process GO:0051052 178 97 2,000 0,01014335 0,05181509 ! response to virus GO:0009615 160 98 2,000 0,01042918 0,05316228 ! regulation of striated muscle tissue development GO:0016202 69 34 1,000 0,01062382 0,05403999 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 1,000 0,01062382 0,05392599 ! mesoderm morphogenesis GO:0048332 76 34 1,000 0,01062382 0,05381246 ! biogenic amine biosynthetic process GO:0042401 62 34 1,000 0,01062382 0,05369941 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 1,000 0,01062382 0,05358683 ! regulation of muscle development GO:0048634 70 35 1,000 0,01123415 0,05654681 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,01123415 0,05642876 ! negative regulation of DNA metabolic process GO:0051053 61 35 1,000 0,01123415 0,0563112 ! regulation of synaptic plasticity GO:0048167 64 35 1,000 0,01123415 0,05619413 ! female gonad development GO:0008585 58 35 1,000 0,01123415 0,05607754 ! telencephalon development GO:0021537 68 35 1,000 0,01123415 0,05596144 ! calcium-mediated signaling GO:0019722 62 35 1,000 0,01123415 0,05584582 ! regulation of microtubule-based process GO:0032886 78 35 1,000 0,01123415 0,05573067 ! neural tube formation GO:0001841 67 35 1,000 0,01123415 0,055616 ! androgen receptor signaling pathway GO:0030521 74 36 1,000 0,0118596 0,05859177 ! embryonic organ development GO:0048568 57 36 1,000 0,0118596 0,0584717 ! negative regulation of cell activation GO:0050866 65 36 1,000 0,0118596 0,05835213 ! tissue remodeling GO:0048771 76 37 1,000 0,0125 0,06137755 ! monovalent inorganic cation homeostasis GO:0055067 58 37 1,000 0,0125 0,06125255 ! regulation of protein stability GO:0031647 73 37 1,000 0,0125 0,06112805 ! glycogen metabolic process GO:0005977 61 37 1,000 0,0125 0,06100406 ! pigment metabolic process GO:0042440 80 37 1,000 0,0125 0,06088057 ! regulation of neuron projection development GO:0010975 91 38 1,000 0,01315522 0,06394233 ! development of primary female sexual characteristics GO:0046545 67 38 1,000 0,01315522 0,06381341 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 67 38 1,000 0,01315522 0,06368502 ! lipid homeostasis GO:0055088 67 38 1,000 0,01315522 0,06355713 ! embryonic epithelial tube formation GO:0001838 72 38 1,000 0,01315522 0,06342977 ! glucan metabolic process GO:0044042 62 38 1,000 0,01315522 0,06330291 GO:0006073|cellular glucan metabolic process, ! learning GO:0007612 77 39 1,000 0,0138251 0,06639359 ! ear morphogenesis GO:0042471 60 39 1,000 0,0138251 0,06626134 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,0138251 0,0661296 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,0138251 0,06599839 ! multicellular organismal metabolic process GO:0044236 57 40 1,000 0,0145095 0,06912844 ! regulation of T cell differentiation GO:0045580 70 41 1,000 0,01520828 0,07231447 ! gliogenesis GO:0042063 88 41 1,000 0,01520828 0,07217184 ! regulation of T cell proliferation GO:0042129 71 41 1,000 0,01520828 0,07202977 ! female gamete generation GO:0007292 61 41 1,000 0,01520828 0,07188826 ! negative regulation of protein complex disassembly GO:0043242 101 42 1,000 0,01592129 0,07511102 ! energy reserve metabolic process GO:0006112 74 43 1,000 0,01664838 0,0783875 ! glucose transport GO:0015758 65 43 1,000 0,01664838 0,0782344 ! striated muscle cell differentiation GO:0051146 82 43 1,000 0,01664838 0,07808189 ! hexose transport GO:0008645 67 44 1,000 0,01738942 0,08139875 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 1,000 0,01738942 0,08124069 ! male sex differentiation GO:0046661 76 44 1,000 0,01738942 0,08108325 ! double-strand break repair GO:0006302 81 44 1,000 0,01738942 0,08092641 ! biopolymer methylation GO:0043414 84 44 1,000 0,01738942 0,08077019 ! JAK-STAT cascade GO:0007259 71 44 1,000 0,01738942 0,08061456 ! maintenance of location in cell GO:0051651 97 44 1,000 0,01738942 0,08045953 ! detection of stimulus involved in sensory perception GO:0050906 66 45 1,000 0,01814427 0,08379101 ! cell growth GO:0016049 84 45 1,000 0,01814427 0,08363049 ! negative regulation of cell migration GO:0030336 115 46 1,000 0,01891278 0,08700602 ! vascular process in circulatory system GO:0003018 80 47 1,000 0,01969481 0,09043077 ! methylation GO:0032259 90 47 1,000 0,01969481 0,09025852 ! morphogenesis of embryonic epithelium GO:0016331 91 48 1,000 0,02049024 0,0937253 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 1,000 0,02049024 0,09354745 ! regulation of lymphocyte differentiation GO:0045619 81 48 1,000 0,02049024 0,09337028 ! regulation of mast cell proliferation GO:0070666 81 48 1,000 0,02049024 0,09319378 ! regulation of action potential GO:0001508 95 49 1,000 0,02129891 0,096689 ! regulation of protein complex disassembly GO:0043244 113 49 1,000 0,02129891 0,09650691 ! response to temperature stimulus GO:0009266 76 49 1,000 0,02129891 0,09632551 ! detection of abiotic stimulus GO:0009582 74 49 1,000 0,02129891 0,09614479 ! regulation of cell projection organization GO:0031344 121 50 1,000 0,02212069 0,09966739 ! regulation of gene expression, epigenetic GO:0040029 105 50 1,000 0,02212069 0,09948109 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,02270314 0,10191 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,02270314 0,10172023 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,02270314 0,10153116 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,02270314 0,10134279 ! neuron fate determination GO:0048664 7 5 0,000 0,02270314 0,10115512 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02270314 0,10096814 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,02270314 0,10078185 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,02270314 0,10059625 ! polyol transport GO:0015791 12 5 0,000 0,02270314 0,10041133 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,02270314 0,10022709 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,02270314 0,10004352 ! response to superoxide GO:0000303 10 5 0,000 0,02270314 0,09986063 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,02270314 0,0996784 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,02270314 0,09949683 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,02270314 0,09931593 ! female meiosis GO:0007143 7 5 0,000 0,02270314 0,09913568 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02270314 0,09895609 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,02270314 0,09877715 ! cobalt ion transport GO:0006824 11 5 0,000 0,02270314 0,09859885 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,02270314 0,09842119 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,02270314 0,09824418 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,02270314 0,0980678 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,02270314 0,09789205 ! phospholipid dephosphorylation GO:0046839 12 5 0,000 0,02270314 0,09771693 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,02270314 0,09754243 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,02270314 0,09736856 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,02270314 0,09719531 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,02270314 0,09702267 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,02270314 0,09685064 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02270314 0,09667923 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02270314 0,09650841 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02270314 0,09633821 ! negative chemotaxis GO:0050919 14 5 0,000 0,02270314 0,0961686 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02270314 0,09599958 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,02270314 0,09583116 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,02270314 0,09566333 ! behavioral response to pain GO:0048266 9 5 0,000 0,02270314 0,09549609 ! clathrin coat assembly GO:0048268 14 5 0,000 0,02270314 0,09532943 ! Notch receptor processing GO:0007220 8 5 0,000 0,02270314 0,09516335 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02270314 0,09499785 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02270314 0,09483292 ! micturition GO:0060073 9 5 0,000 0,02270314 0,09466857 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,02270314 0,09450478 ! copulation GO:0007620 9 5 0,000 0,02270314 0,09434156 ! glial cell fate commitment GO:0021781 13 5 0,000 0,02270314 0,0941789 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,02270314 0,0940168 ! spermidine metabolic process GO:0008216 7 5 0,000 0,02270314 0,09385526 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,02270314 0,09369427 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,02270314 0,09353384 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,02270314 0,09337395 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,02270314 0,09321461 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,02270314 0,09305581 ! grooming behavior GO:0007625 6 5 0,000 0,02270314 0,09289755 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,02270314 0,09273983 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,02270314 0,09258265 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02270314 0,09242599 ! response to protozoan GO:0001562 10 5 0,000 0,02270314 0,09226987 ! positive regulation of glycolysis GO:0045821 14 5 0,000 0,02270314 0,09211427 ! lymph vessel development GO:0001945 10 5 0,000 0,02270314 0,0919592 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,02270314 0,09180464 ! endochondral ossification GO:0001958 16 5 0,000 0,02270314 0,09165061 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,02270314 0,09149709 ! parathyroid gland development GO:0060017 13 5 0,000 0,02270314 0,09134408 ! anagen GO:0042640 6 5 0,000 0,02270314 0,09119159 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,02270314 0,0910396 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,02270314 0,09088812 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 0,000 0,02270314 0,09073715 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,02270314 0,09058667 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,02270314 0,09043669 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,02270314 0,09028721 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,02270314 0,09013822 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,02270314 0,08998972 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,02270314 0,08984171 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,02270314 0,08969419 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,02270314 0,08954715 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,02270314 0,08940059 ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,02270314 0,08925451 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,02270314 0,08910891 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,02270314 0,08896378 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,02270314 0,08881913 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,02270314 0,08867494 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,02270314 0,08853122 ! histidine catabolic process GO:0006548 6 5 0,000 0,02270314 0,08838796 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,02270314 0,08824517 ! microvillus organization GO:0032528 7 5 0,000 0,02270314 0,08810284 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 10 5 0,000 0,02270314 0,08796097 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,02270314 0,08781955 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02270314 0,08767859 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,02270314 0,08753808 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,02270314 0,08739802 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02270314 0,08725841 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,02270314 0,08711924 ! polyol catabolic process GO:0046174 7 5 0,000 0,02270314 0,08698051 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02270314 0,08684223 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02270314 0,08670438 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02270314 0,08656698 ! muscle cell migration GO:0014812 8 5 0,000 0,02270314 0,08643 ! mitochondrial fission GO:0000266 8 5 0,000 0,02270314 0,08629346 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,02270314 0,08615735 ! mRNA transcription GO:0009299 9 5 0,000 0,02270314 0,08602167 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,02270314 0,08588642 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,02270314 0,08575159 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,02270314 0,08561718 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02270314 0,0854832 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,02270314 0,08534963 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,02270314 0,08521648 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,02270314 0,08508374 ! response to food GO:0032094 6 5 0,000 0,02270314 0,08495142 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,02270314 0,08481951 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,02270314 0,084688 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,02270314 0,08455691 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02270314 0,08442622 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,02270314 0,08429593 ! forebrain neuron development GO:0021884 13 5 0,000 0,02270314 0,08416604 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,02270314 0,08403656 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,02270314 0,08390747 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,02270314 0,08377878 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02270314 0,08365048 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,02270314 0,08352257 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02270314 0,08339506 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,02270314 0,08326793 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,02270314 0,08314119 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02270314 0,08301484 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,02270314 0,08288887 ! basic amino acid transport GO:0015802 11 5 0,000 0,02270314 0,08276328 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,02270314 0,08263807 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,02270314 0,08251324 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02270314 0,08238878 ! depyrimidination GO:0045008 10 5 0,000 0,02270314 0,0822647 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,02270314 0,082141 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02270314 0,08201766 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,02270314 0,0818947 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 7 5 0,000 0,02270314 0,0817721 ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,02270314 0,08164987 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02270314 0,081528 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,02270314 0,0814065 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,02270314 0,08128536 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,02270314 0,08116458 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,02270314 0,08104416 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,02270314 0,08092409 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02270314 0,08080438 ! response to arsenic GO:0046685 10 5 0,000 0,02270314 0,08068503 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,02270314 0,08056602 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,02270314 0,08044737 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,02270314 0,08032906 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,02270314 0,0802111 ! response to cadmium ion GO:0046686 7 5 0,000 0,02270314 0,08009349 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,02270314 0,07997623 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,02270314 0,0798593 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,02270314 0,07974272 ! decidualization GO:0046697 11 5 0,000 0,02270314 0,07962648 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,02270314 0,07951057 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,02270314 0,079395 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02270314 0,07927977 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02270314 0,07916487 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,02270314 0,07905031 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02270314 0,07893607 ! neural tube patterning GO:0021532 7 5 0,000 0,02270314 0,07882217 ! embryonic cleavage GO:0040016 6 5 0,000 0,02270314 0,07870859 ! peroxisome fission GO:0016559 5 5 0,000 0,02270314 0,07859534 ! histone demethylation GO:0016577 10 5 0,000 0,02270314 0,07848242 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,02270314 0,07836982 ! mitotic recombination GO:0006312 9 5 0,000 0,02270314 0,07825754 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,02270314 0,07814558 ! metaphase plate congression GO:0051310 7 5 0,000 0,02270314 0,07803395 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02270314 0,07792263 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,02270314 0,07781163 ! enteric nervous system development GO:0048484 8 5 0,000 0,02270314 0,07770094 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,02270314 0,07759057 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,02270314 0,07748051 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,02270314 0,07737077 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,02270314 0,07726133 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,02270314 0,07715221 ! plasminogen activation GO:0031639 5 5 0,000 0,02270314 0,07704339 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,02270314 0,07693488 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,02270314 0,07682667 ! metaphase GO:0051323 8 5 0,000 0,02270314 0,07671877 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,02270314 0,07661117 ! cellular response to nutrient GO:0031670 8 5 0,000 0,02270314 0,07650387 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,02270314 0,07639687 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02270314 0,07629017 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02270314 0,07618377 GO:0015991|ATP hydrolysis coupled proton transport, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,02270314 0,07607766 ! response to redox state GO:0051775 5 5 0,000 0,02270314 0,07597185 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,02270314 0,07586634 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,02270314 0,07576111 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,02270314 0,07565618 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,02270314 0,07555154 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02270314 0,07544719 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,02270314 0,07534312 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02270314 0,07523934 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,02270314 0,07513585 ! striatum development GO:0021756 9 5 0,000 0,02270314 0,07503264 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,02270314 0,07492972 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,02270314 0,07482707 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,02270314 0,07472471 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,02270314 0,07462263 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02270314 0,07452082 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,02270314 0,07441929 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,02270314 0,07431804 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,02270314 0,07421707 ! neuroprotection GO:0043526 6 5 0,000 0,02270314 0,07411637 ! neural plate development GO:0001840 8 5 0,000 0,02270314 0,07401594 ! regulation of sensory perception GO:0051931 7 5 0,000 0,02270314 0,07391578 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,02270314 0,07381589 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,02270314 0,07371628 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,02270314 0,07361693 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,02270314 0,07351785 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,02270314 0,07341904 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02270314 0,07332049 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,02270314 0,0732222 ! spindle assembly GO:0051225 6 5 0,000 0,02270314 0,07312418 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,02270314 0,07302642 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,02270314 0,07292892 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,02270314 0,07283168 ! drug metabolic process GO:0017144 6 5 0,000 0,02270314 0,0727347 ! phospholipid scrambling GO:0017121 8 5 0,000 0,02270314 0,07263798 ! organ regeneration GO:0031100 7 5 0,000 0,02270314 0,07254152 ! carnitine metabolic process GO:0009437 7 5 0,000 0,02270314 0,07244531 GO:0006577|betaine metabolic process, ! cellular anion homeostasis GO:0030002 9 5 0,000 0,02270314 0,07234935 GO:0055081|anion homeostasis, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,02270314 0,07225365 ! vesicle organization GO:0016050 107 51 1,000 0,02295545 0,07296014 ! regulation of leukocyte proliferation GO:0070663 88 51 1,000 0,02295545 0,07286388 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of cell shape GO:0008360 125 51 1,000 0,02295545 0,07276788 ! regulation of angiogenesis GO:0045765 114 52 1,000 0,02380306 0,07535548 ! amino acid activation GO:0043038 92 52 1,000 0,02380306 0,07525646 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! synapse organization GO:0050808 85 52 1,000 0,02380306 0,0751577 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,02553627 0,0805246 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 1,000 0,02553627 0,08041921 ! cell recognition GO:0008037 85 54 1,000 0,02553627 0,08031408 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 1,000 0,02553627 0,08020923 ! cellular polysaccharide metabolic process GO:0044264 86 55 1,000 0,02642161 0,08288188 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,02642161 0,08277396 ! gastrulation GO:0007369 112 55 1,000 0,02642161 0,08266633 ! negative regulation of cell motion GO:0051271 134 55 1,000 0,02642161 0,08255897 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02718199 0,08482472 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02718199 0,08471485 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,02718199 0,08460526 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02718199 0,08449595 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02718199 0,08438692 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,02718199 0,08427817 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,02718199 0,08416971 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02718199 0,08406152 ! sleep GO:0030431 13 6 0,000 0,02718199 0,08395361 ! response to oxygen radical GO:0000305 11 6 0,000 0,02718199 0,08384598 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,02718199 0,08373862 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,02718199 0,08363154 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,02718199 0,08352473 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,02718199 0,08341819 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02718199 0,08331193 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02718199 0,08320593 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,02718199 0,08310021 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02718199 0,08299475 ! male meiosis GO:0007140 7 6 0,000 0,02718199 0,08288956 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02718199 0,08278464 ! response to zinc ion GO:0010043 9 6 0,000 0,02718199 0,08267998 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02718199 0,08257558 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,02718199 0,08247145 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,02718199 0,08236758 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02718199 0,08226398 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02718199 0,08216063 ! malate metabolic process GO:0006108 11 6 0,000 0,02718199 0,08205754 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,02718199 0,08195471 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,02718199 0,08185214 ! protein refolding GO:0042026 15 6 0,000 0,02718199 0,08174983 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02718199 0,08164777 ! opsonization GO:0008228 8 6 0,000 0,02718199 0,08154596 ! mating behavior GO:0007617 7 6 0,000 0,02718199 0,08144441 ! neuron remodeling GO:0016322 15 6 0,000 0,02718199 0,08134311 ! erythrocyte maturation GO:0043249 7 6 0,000 0,02718199 0,08124206 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,02718199 0,08114127 ! equilibrioception GO:0050957 14 6 0,000 0,02718199 0,08104072 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,02718199 0,08094042 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,02718199 0,08084037 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02718199 0,08074057 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,02718199 0,08064101 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02718199 0,0805417 ! response to interferon-gamma GO:0034341 15 6 0,000 0,02718199 0,08044263 ! toxin metabolic process GO:0009404 11 6 0,000 0,02718199 0,08034381 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02718199 0,08024523 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02718199 0,08014689 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,02718199 0,08004879 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,02718199 0,07995093 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,02718199 0,07985331 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,02718199 0,07975593 ! thymic T cell selection GO:0045061 12 6 0,000 0,02718199 0,07965878 ! protein lipoylation GO:0009249 10 6 0,000 0,02718199 0,07956188 ! cysteine metabolic process GO:0006534 10 6 0,000 0,02718199 0,0794652 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02718199 0,07936876 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02718199 0,07927256 ! glutamate catabolic process GO:0006538 10 6 0,000 0,02718199 0,07917659 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,02718199 0,07908085 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02718199 0,07898534 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,02718199 0,07889006 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,02718199 0,07879501 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02718199 0,0787002 ! hyperosmotic response GO:0006972 9 6 0,000 0,02718199 0,0786056 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,02718199 0,07851124 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,02718199 0,0784171 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02718199 0,07832319 ! urea metabolic process GO:0019627 7 6 0,000 0,02718199 0,0782295 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02718199 0,07813604 ! neutrophil activation GO:0042119 8 6 0,000 0,02718199 0,0780428 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02718199 0,07794978 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,02718199 0,07785698 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02718199 0,0777644 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02718199 0,07767205 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02718199 0,07757991 ! neuron apoptosis GO:0051402 9 6 0,000 0,02718199 0,07748799 ! nucleoside salvage GO:0043174 9 6 0,000 0,02718199 0,07739629 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,02718199 0,0773048 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02718199 0,07721353 ! T cell mediated immunity GO:0002456 16 6 0,000 0,02718199 0,07712248 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02718199 0,07703164 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 0,000 0,02718199 0,07694101 ! carnitine transport GO:0015879 10 6 0,000 0,02718199 0,0768506 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,02718199 0,0767604 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02718199 0,07667041 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,02718199 0,07658063 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,02718199 0,07649107 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,02718199 0,07640171 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02718199 0,07631256 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,02718199 0,07622362 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,02718199 0,07613488 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,02718199 0,07604635 ! establishment of spindle localization GO:0051293 12 6 0,000 0,02718199 0,07595803 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,02718199 0,07586991 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02718199 0,075782 GO:0045686|negative regulation of glial cell differentiation, ! monocyte differentiation GO:0030224 12 6 0,000 0,02718199 0,07569428 ! response to UV-C GO:0010225 11 6 0,000 0,02718199 0,07560678 ! astrocyte development GO:0014002 15 6 0,000 0,02718199 0,07551947 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,02718199 0,07543237 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02718199 0,07534546 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02718199 0,07525876 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02718199 0,07517226 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,02718199 0,07508595 ! response to copper ion GO:0046688 10 6 0,000 0,02718199 0,07499984 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,02718199 0,07491393 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,02718199 0,07482822 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02718199 0,0747427 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02718199 0,07465738 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 0,000 0,02718199 0,07457225 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,02718199 0,07448731 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02718199 0,07440257 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,02718199 0,07431803 ! hair follicle maturation GO:0048820 7 6 0,000 0,02718199 0,07423367 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02718199 0,0741495 ! Schwann cell development GO:0014044 15 6 0,000 0,02718199 0,07406553 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,02718199 0,07398174 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02718199 0,07389815 ! subpallium development GO:0021544 10 6 0,000 0,02718199 0,07381474 ! histone ubiquitination GO:0016574 8 6 0,000 0,02718199 0,07373152 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,02718199 0,07364849 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02718199 0,07356565 ! G2 phase GO:0051319 16 6 0,000 0,02718199 0,07348299 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,02718199 0,07340052 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02718199 0,07331823 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,02718199 0,07323613 ! membrane to membrane docking GO:0022614 14 6 0,000 0,02718199 0,07315421 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02718199 0,07307247 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,02718199 0,07299092 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02718199 0,07290955 ! receptor internalization GO:0031623 10 6 0,000 0,02718199 0,07282835 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,02718199 0,07274734 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,02718199 0,07266651 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02718199 0,07258586 GO:0043011|myeloid dendritic cell differentiation, ! protein deubiquitination GO:0016579 14 6 0,000 0,02718199 0,07250539 ! protein destabilization GO:0031648 9 6 0,000 0,02718199 0,0724251 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,02718199 0,07234498 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,02718199 0,07226504 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02718199 0,07218528 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,02718199 0,07210569 ! progesterone metabolic process GO:0042448 10 6 0,000 0,02718199 0,07202628 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,02718199 0,07194704 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,02718199 0,07186798 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,02718199 0,07178909 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02718199 0,07171038 ! determination of adult lifespan GO:0008340 15 6 0,000 0,02718199 0,07163183 ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,02718199 0,07155346 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02718199 0,07147526 ! catecholamine transport GO:0051937 9 6 0,000 0,02718199 0,07139723 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,02718199 0,07131937 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02718199 0,07124168 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02718199 0,07116416 ! cytoplasmic microtubule organization GO:0031122 14 6 0,000 0,02718199 0,07108681 ! maternal placenta development GO:0001893 12 6 0,000 0,02718199 0,07100962 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,02718199 0,07093261 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02718199 0,07085576 ! negative regulation of B cell activation GO:0050869 13 6 0,000 0,02718199 0,07077907 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,02718199 0,07070255 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02718199 0,0706262 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,02718199 0,07055001 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,02718199 0,07047399 ! skeletal muscle fiber development GO:0048741 111 56 1,000 0,02731927 0,07075368 ! nucleotide-excision repair GO:0006289 83 56 1,000 0,02731927 0,0706776 ! regulation of DNA replication GO:0006275 101 56 1,000 0,02731927 0,07060168 ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 1,000 0,02822911 0,07287473 ! muscle fiber development GO:0048747 112 57 1,000 0,02822911 0,07279662 ! lipid modification GO:0030258 97 57 1,000 0,02822911 0,07271868 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,02822911 0,07264091 ! maintenance of location GO:0051235 118 57 1,000 0,02822911 0,0725633 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,02915102 0,07485309 ! DNA catabolic process GO:0006308 86 59 1,000 0,03008485 0,07716859 ! camera-type eye development GO:0043010 116 60 1,000 0,03103048 0,0795094 ! tRNA transcription GO:0009304 14 7 0,000 0,03164045 0,0809861 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,03164045 0,08090003 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,03164045 0,08081415 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,03164045 0,08072845 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,03164045 0,08064294 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,03164045 0,0805576 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,03164045 0,08047244 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,03164045 0,08038747 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,03164045 0,08030267 ! prostate gland development GO:0030850 13 7 0,000 0,03164045 0,08021805 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,03164045 0,08013361 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03164045 0,08004935 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,03164045 0,07996527 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,03164045 0,07988136 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03164045 0,07979762 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,03164045 0,07971407 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,03164045 0,07963068 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,03164045 0,07954747 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,03164045 0,07946444 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,03164045 0,07938158 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,03164045 0,07929889 ! glycolipid transport GO:0046836 10 7 0,000 0,03164045 0,07921637 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,03164045 0,07913403 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,03164045 0,07905185 ! N-terminal protein amino acid acetylation GO:0006474 13 7 0,000 0,03164045 0,07896985 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,03164045 0,07888801 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,03164045 0,07880635 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,03164045 0,07872485 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,03164045 0,07864353 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,03164045 0,07856237 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,03164045 0,07848137 ! pericardium development GO:0060039 14 7 0,000 0,03164045 0,07840055 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,03164045 0,07831989 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,03164045 0,0782394 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,03164045 0,07815907 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03164045 0,07807891 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,03164045 0,07799891 ! lipoprotein transport GO:0042953 14 7 0,000 0,03164045 0,07791907 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03164045 0,0778394 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03164045 0,07775989 ! rhythmic behavior GO:0007622 15 7 0,000 0,03164045 0,07768054 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,03164045 0,07760136 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,03164045 0,07752233 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,03164045 0,07744347 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,03164045 0,07736477 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,03164045 0,07728623 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,03164045 0,07720784 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,03164045 0,07712962 ! mechanosensory behavior GO:0007638 14 7 0,000 0,03164045 0,07705155 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,03164045 0,07697364 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03164045 0,07689589 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,03164045 0,0768183 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03164045 0,07674086 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03164045 0,07666358 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,03164045 0,07658645 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,03164045 0,07650948 ! adrenal gland development GO:0030325 17 7 0,000 0,03164045 0,07643266 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,03164045 0,076356 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,03164045 0,07627949 ! ovulation GO:0030728 9 7 0,000 0,03164045 0,07620314 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,03164045 0,07612693 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,03164045 0,07605088 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,03164045 0,07597498 ! microtubule nucleation GO:0007020 20 7 0,000 0,03164045 0,07589923 ! proline biosynthetic process GO:0006561 10 7 0,000 0,03164045 0,07582364 ! thyroid hormone generation GO:0006590 13 7 0,000 0,03164045 0,07574819 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,03164045 0,0756729 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,03164045 0,07559775 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,03164045 0,07552275 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03164045 0,0754479 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03164045 0,0753732 ! galactose metabolic process GO:0006012 13 7 0,000 0,03164045 0,07529865 ! vesicle fusion GO:0006906 17 7 0,000 0,03164045 0,07522424 ! response to dietary excess GO:0002021 8 7 0,000 0,03164045 0,07514998 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,03164045 0,07507587 ! intracellular pH reduction GO:0051452 11 7 0,000 0,03164045 0,0750019 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,03164045 0,07492808 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,03164045 0,07485441 ! purine salvage GO:0043101 10 7 0,000 0,03164045 0,07478088 ! nucleoside transport GO:0015858 8 7 0,000 0,03164045 0,07470749 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,03164045 0,07463425 ! parturition GO:0007567 14 7 0,000 0,03164045 0,07456115 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,03164045 0,07448819 ! rRNA modification GO:0000154 14 7 0,000 0,03164045 0,07441538 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,03164045 0,07434271 ! spindle checkpoint GO:0031577 15 7 0,000 0,03164045 0,07427018 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,03164045 0,07419779 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,03164045 0,07412554 ! macrophage differentiation GO:0030225 11 7 0,000 0,03164045 0,07405344 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03164045 0,07398147 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,03164045 0,07390964 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,03164045 0,07383796 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,03164045 0,07376641 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,03164045 0,073695 ! fibrinolysis GO:0042730 10 7 0,000 0,03164045 0,07362373 ! eating behavior GO:0042755 7 7 0,000 0,03164045 0,07355259 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,03164045 0,0734816 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,03164045 0,07341074 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,03164045 0,07334001 ! negative regulation of focal adhesion formation GO:0051895 20 7 0,000 0,03164045 0,07326943 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,03164045 0,07319897 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,03164045 0,07312866 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,03164045 0,07305848 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,03164045 0,07298843 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,03164045 0,07291852 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,03164045 0,07284874 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,03164045 0,07277909 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,03164045 0,07270958 ! regulation of meiosis GO:0040020 12 7 0,000 0,03164045 0,0726402 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,03164045 0,07257096 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,03164045 0,07250184 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,03164045 0,07243286 ! oxygen homeostasis GO:0032364 12 7 0,000 0,03164045 0,072364 ! transcription termination GO:0006353 13 7 0,000 0,03164045 0,07229528 ! regulation of respiratory burst GO:0060263 11 7 0,000 0,03164045 0,07222669 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,03164045 0,07215823 ! anaphase GO:0051322 17 7 0,000 0,03164045 0,0720899 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,03164045 0,0720217 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,03164045 0,07195362 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,03164045 0,07188568 ! diuresis GO:0030146 12 7 0,000 0,03164045 0,07181786 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,03164045 0,07175017 ! thiamin metabolic process GO:0006772 7 7 0,000 0,03164045 0,07168261 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03164045 0,07161518 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,03164045 0,07154787 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,03164045 0,07148069 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,03164045 0,07141363 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03164045 0,0713467 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03164045 0,0712799 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03164045 0,07121322 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,03164045 0,07114667 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,03164045 0,07108024 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,03164045 0,07101393 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,03164045 0,07094775 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03164045 0,07088169 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,03164045 0,07081575 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,03164045 0,07074994 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,03164045 0,07068425 ! adult feeding behavior GO:0008343 9 7 0,000 0,03164045 0,07061868 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,03164045 0,07055323 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,03164045 0,0704879 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,03164045 0,07042269 ! muscle adaptation GO:0043500 14 7 0,000 0,03164045 0,07035761 ! embryonic heart tube development GO:0035050 10 7 0,000 0,03164045 0,07029264 ! retina homeostasis GO:0001895 12 7 0,000 0,03164045 0,0702278 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,03164045 0,07016307 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,03164045 0,07009846 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,03164045 0,07003398 ! protein prenylation GO:0018342 18 7 0,000 0,03164045 0,06996961 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,03164045 0,06990536 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,03164045 0,06984122 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03164045 0,06977721 ! mesoderm development GO:0007498 119 61 1,000 0,03198779 0,07047858 ! gonad development GO:0008406 98 62 1,000 0,03295665 0,07254683 ! detection of external stimulus GO:0009581 91 63 1,000 0,03393693 0,07463644 ! steroid hormone receptor signaling pathway GO:0030518 129 63 1,000 0,03393693 0,07456827 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 1,000 0,03492852 0,07667703 ! multicellular organism reproduction GO:0032504 111 64 1,000 0,03492852 0,07660714 GO:0048609|reproductive process in a multicellular organism, ! germ cell development GO:0007281 118 65 1,000 0,0359313 0,0787347 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,03607863 0,07898562 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,03607863 0,07891381 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 0,000 0,03607863 0,07884214 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,03607863 0,07877059 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,03607863 0,07869918 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,03607863 0,07862789 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,03607863 0,07855674 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,03607863 0,07848571 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,03607863 0,07841481 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,03607863 0,07834404 ! meiotic prophase I GO:0007128 13 8 0,000 0,03607863 0,0782734 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,03607863 0,07820288 ! oligopeptide transport GO:0006857 15 8 0,000 0,03607863 0,07813249 ! UTP metabolic process GO:0046051 8 8 0,000 0,03607863 0,07806223 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,03607863 0,07799209 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,03607863 0,07792208 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,03607863 0,07785219 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,03607863 0,07778243 ! succinate metabolic process GO:0006105 14 8 0,000 0,03607863 0,0777128 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03607863 0,07764329 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,03607863 0,0775739 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,03607863 0,07750464 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,03607863 0,0774355 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03607863 0,07736648 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,03607863 0,07729759 ! reflex GO:0060004 16 8 0,000 0,03607863 0,07722882 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,03607863 0,07716017 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,03607863 0,07709165 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,03607863 0,07702324 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,03607863 0,07695496 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,03607863 0,0768868 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,03607863 0,07681876 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,03607863 0,07675084 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,03607863 0,07668303 ! astrocyte differentiation GO:0048708 18 8 0,000 0,03607863 0,07661535 ! histidine metabolic process GO:0006547 16 8 0,000 0,03607863 0,07654779 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,03607863 0,07648035 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,03607863 0,07641302 ! glycine catabolic process GO:0006546 13 8 0,000 0,03607863 0,07634582 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,03607863 0,07627873 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,03607863 0,07621176 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,03607863 0,07614491 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,03607863 0,07607817 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03607863 0,07601155 ! macrophage activation GO:0042116 12 8 0,000 0,03607863 0,07594505 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,03607863 0,07587867 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,03607863 0,0758124 ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,03607863 0,07574624 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,03607863 0,07568021 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,03607863 0,07561428 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,03607863 0,07554847 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,03607863 0,07548278 ! osteoblast development GO:0002076 16 8 0,000 0,03607863 0,0754172 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,03607863 0,07535173 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,03607863 0,07528638 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,03607863 0,07522114 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,03607863 0,07515601 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,03607863 0,075091 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,03607863 0,0750261 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,03607863 0,07496131 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,03607863 0,07489663 ! intermediate filament organization GO:0045109 12 8 0,000 0,03607863 0,07483206 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,03607863 0,07476761 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,03607863 0,07470327 ! cellular extravasation GO:0045123 12 8 0,000 0,03607863 0,07463903 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,03607863 0,07457491 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,03607863 0,0745109 ! response to antibiotic GO:0046677 11 8 0,000 0,03607863 0,07444699 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,03607863 0,0743832 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,03607863 0,07431952 ! DNA topological change GO:0006265 12 8 0,000 0,03607863 0,07425594 ! response to tropane GO:0014073 15 8 0,000 0,03607863 0,07419247 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,03607863 0,07412912 ! melanosome transport GO:0032402 13 8 0,000 0,03607863 0,07406587 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,03607863 0,07400272 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,03607863 0,07393969 ! mast cell activation GO:0045576 14 8 0,000 0,03607863 0,07387676 ! multicellular organismal aging GO:0010259 18 8 0,000 0,03607863 0,07381394 ! regulation of focal adhesion formation GO:0051893 22 8 0,000 0,03607863 0,07375123 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,03607863 0,07368862 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,03607863 0,07362612 ! nucleosome disassembly GO:0006337 14 8 0,000 0,03607863 0,07356372 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,03607863 0,07350144 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,03607863 0,07343925 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03607863 0,07337717 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,03607863 0,0733152 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,03607863 0,07325333 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,03607863 0,07319156 ! intracellular lipid transport GO:0032365 13 8 0,000 0,03607863 0,0731299 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,03607863 0,07306835 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03607863 0,07300689 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,03607863 0,07294554 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,03607863 0,07288429 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,03607863 0,07282315 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,03607863 0,07276211 ! hormone catabolic process GO:0042447 17 8 0,000 0,03607863 0,07270117 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,03607863 0,07264033 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,03607863 0,07257959 ! ATP catabolic process GO:0006200 11 8 0,000 0,03607863 0,07251896 ! blastocyst growth GO:0001832 19 8 0,000 0,03607863 0,07245843 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,03607863 0,07239799 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,03607863 0,07233766 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,03607863 0,07227743 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,03607863 0,0722173 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03607863 0,07215727 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,03607863 0,07209734 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,03607863 0,07203751 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,03607863 0,07197777 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,03607863 0,07191814 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,03607863 0,07185861 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,03607863 0,07179917 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,03607863 0,07173983 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,03607863 0,07168059 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03607863 0,07162145 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,03607863 0,0715624 ! secondary metabolic process GO:0019748 116 66 1,000 0,03694513 0,07322074 ! regulation of cellular response to stress GO:0080135 128 67 1,000 0,0379699 0,07518977 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,0379699 0,07512793 ! adaptive immune response GO:0002250 119 67 1,000 0,0379699 0,0750662 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 1,000 0,03900548 0,07705024 ! regulation of lipase activity GO:0060191 130 68 1,000 0,03900548 0,07698703 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 1,000 0,03900548 0,07692393 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 1,000 0,04005177 0,07892265 ! regulation of developmental growth GO:0048638 15 9 0,000 0,04049662 0,07973394 ! axon extension GO:0048675 15 9 0,000 0,04049662 0,07966874 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,04049662 0,07960365 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,04049662 0,07953867 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,04049662 0,07947379 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,04049662 0,07940902 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,04049662 0,07934436 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,04049662 0,0792798 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,04049662 0,07921534 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,04049662 0,07915099 ! phosphate transport GO:0006817 19 9 0,000 0,04049662 0,07908675 ! reproductive behavior GO:0019098 19 9 0,000 0,04049662 0,0790226 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,04049662 0,07895857 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,04049662 0,07889463 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,04049662 0,0788308 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,04049662 0,07876707 ! GTP metabolic process GO:0046039 9 9 0,000 0,04049662 0,07870345 ! RNA methylation GO:0001510 15 9 0,000 0,04049662 0,07863993 ! elastic fiber assembly GO:0048251 15 9 0,000 0,04049662 0,07857651 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,04049662 0,07851319 ! artery development GO:0060840 24 9 0,000 0,04049662 0,07844998 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,04049662 0,07838686 ! regulation of glycolysis GO:0006110 21 9 0,000 0,04049662 0,07832385 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,04049662 0,07826094 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,04049662 0,07819813 ! chemosensory behavior GO:0007635 20 9 0,000 0,04049662 0,07813542 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,04049662 0,07807281 ! leukocyte degranulation GO:0043299 16 9 0,000 0,04049662 0,0780103 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,04049662 0,0779479 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,04049662 0,07788559 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,04049662 0,07782338 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,04049662 0,07776127 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,04049662 0,07769926 ! protein targeting to ER GO:0045047 22 9 0,000 0,04049662 0,07763735 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,04049662 0,07757553 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,04049662 0,07751382 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,04049662 0,0774522 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04049662 0,07739068 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,04049662 0,07732926 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,04049662 0,07726794 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04049662 0,07720671 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,04049662 0,07714558 ! mannose metabolic process GO:0006013 13 9 0,000 0,04049662 0,07708455 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,04049662 0,07702361 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,04049662 0,07696277 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,04049662 0,07690203 ! receptor clustering GO:0043113 18 9 0,000 0,04049662 0,07684138 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,04049662 0,07678083 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,04049662 0,07672037 ! ruffle organization GO:0031529 15 9 0,000 0,04049662 0,07666001 ! retinol metabolic process GO:0042572 18 9 0,000 0,04049662 0,07659974 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,04049662 0,07653957 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,04049662 0,07647949 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,04049662 0,07641951 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,04049662 0,07635962 GO:0030204|chondroitin sulfate metabolic process, ! protein heterooligomerization GO:0051291 16 9 0,000 0,04049662 0,07629982 ! oligodendrocyte development GO:0014003 10 9 0,000 0,04049662 0,07624012 ! segment specification GO:0007379 13 9 0,000 0,04049662 0,07618051 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,04049662 0,07612099 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,04049662 0,07606157 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,04049662 0,07600224 ! response to amine stimulus GO:0014075 13 9 0,000 0,04049662 0,075943 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,04049662 0,07588386 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,04049662 0,0758248 ! erythrocyte development GO:0048821 15 9 0,000 0,04049662 0,07576584 ! gas homeostasis GO:0033483 16 9 0,000 0,04049662 0,07570697 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,04049662 0,07564819 ! renal water homeostasis GO:0003091 14 9 0,000 0,04049662 0,0755895 ! postreplication repair GO:0006301 22 9 0,000 0,04049662 0,07553091 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,04049662 0,0754724 ! icosanoid secretion GO:0032309 15 9 0,000 0,04049662 0,07541399 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,04049662 0,07535566 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,04049662 0,07529743 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,04049662 0,07523928 ! regulation of cell division GO:0051302 15 9 0,000 0,04049662 0,07518123 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,04049662 0,07512326 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,04049662 0,07506539 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,04049662 0,0750076 ! sterol catabolic process GO:0016127 11 9 0,000 0,04049662 0,0749499 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,04049662 0,07489229 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,04049662 0,07483477 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,04049662 0,07477734 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,04049662 0,07471999 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,04049662 0,07466274 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,04049662 0,07460557 ! musculoskeletal movement GO:0050881 14 9 0,000 0,04049662 0,07454849 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,04049662 0,07449149 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,04049662 0,07443458 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,04049662 0,07437776 ! purine base metabolic process GO:0006144 21 9 0,000 0,04049662 0,07432103 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,04049662 0,07426438 ! pigment granule transport GO:0051904 17 9 0,000 0,04049662 0,07420782 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,04049662 0,07415135 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,04049662 0,07409496 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,04049662 0,07403866 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04049662 0,07398244 ! reproductive structure development GO:0048608 113 71 1,000 0,04217597 0,07699195 ! regulation of MAPKKK cascade GO:0043408 142 71 1,000 0,04217597 0,07693358 ! phosphoinositide metabolic process GO:0030384 128 72 1,000 0,04325365 0,07883961 ! carbohydrate transport GO:0008643 110 72 1,000 0,04325365 0,07877993 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 1,000 0,04325365 0,07872034 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 1,000 0,04325365 0,07866084 ! learning or memory GO:0007611 147 73 1,000 0,04434157 0,0805784 ! regulation of blood pressure GO:0008217 125 73 1,000 0,04434157 0,08051759 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,0448945 0,08146016 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 0,000 0,0448945 0,08139878 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,0448945 0,08133748 ! positive regulation of B cell proliferation GO:0030890 16 10 0,000 0,0448945 0,08127628 ! synapsis GO:0007129 13 10 0,000 0,0448945 0,08121517 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,0448945 0,08115415 ! N-glycan processing GO:0006491 20 10 0,000 0,0448945 0,08109323 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 0,000 0,0448945 0,08103239 GO:0007520|myoblast fusion, ! social behavior GO:0035176 24 10 0,000 0,0448945 0,08097165 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,0448945 0,08091099 GO:0048200|Golgi transport vesicle coating, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,0448945 0,08085043 ! androgen metabolic process GO:0008209 17 10 0,000 0,0448945 0,08078996 ! phospholipid efflux GO:0033700 16 10 0,000 0,0448945 0,08072958 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,0448945 0,08066929 ! pathogenesis GO:0009405 13 10 0,000 0,0448945 0,08060909 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0448945 0,08054898 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,0448945 0,08048895 ! negative regulation of striated muscle development GO:0045843 19 10 0,000 0,0448945 0,08042902 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,0448945 0,08036918 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,0448945 0,08030943 ! endoderm development GO:0007492 16 10 0,000 0,0448945 0,08024976 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,0448945 0,08019018 ! arginine catabolic process GO:0006527 13 10 0,000 0,0448945 0,0801307 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0448945 0,0800713 ! proline metabolic process GO:0006560 13 10 0,000 0,0448945 0,08001198 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,0448945 0,07995276 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,0448945 0,07989362 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,0448945 0,07983457 ! V(D)J recombination GO:0033151 28 10 0,000 0,0448945 0,07977561 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,0448945 0,07971674 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,0448945 0,07965795 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,0448945 0,07959925 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,0448945 0,07954063 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,0448945 0,0794821 ! multicellular organism growth GO:0035264 18 10 0,000 0,0448945 0,07942366 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,0448945 0,0793653 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,0448945 0,07930703 ! epithelial cell development GO:0002064 20 10 0,000 0,0448945 0,07924885 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,0448945 0,07919075 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0448945 0,07913273 ! macroautophagy GO:0016236 17 10 0,000 0,0448945 0,0790748 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,0448945 0,07901695 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,0448945 0,07895919 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,0448945 0,07890152 ! copper ion homeostasis GO:0055070 13 10 0,000 0,0448945 0,07884392 ! brain morphogenesis GO:0048854 23 10 0,000 0,0448945 0,07878642 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,0448945 0,07872899 ! blastoderm segmentation GO:0007350 18 10 0,000 0,0448945 0,07867165 ! response to dsRNA GO:0043331 20 10 0,000 0,0448945 0,07861439 ! DNA ligation GO:0006266 19 10 0,000 0,0448945 0,07855722 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,0448945 0,07850013 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,0448945 0,07844312 ! melanosome localization GO:0032400 16 10 0,000 0,0448945 0,0783862 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,0448945 0,07832935 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,0448945 0,07827259 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 0,000 0,0448945 0,07821591 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0448945 0,07815932 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,0448945 0,0781028 ! mRNA cleavage GO:0006379 17 10 0,000 0,0448945 0,07804637 ! protein sumoylation GO:0016925 15 10 0,000 0,0448945 0,07799002 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0448945 0,07793375 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0448945 0,07787756 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,0448945 0,07782145 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,0448945 0,07776543 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,0448945 0,07770948 ! prophase GO:0051324 15 10 0,000 0,0448945 0,07765361 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,0448945 0,07759783 ! apical protein localization GO:0045176 15 10 0,000 0,0448945 0,07754212 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,0448945 0,0774865 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,0448945 0,07743095 ! midbrain development GO:0030901 13 10 0,000 0,0448945 0,07737548 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,0448945 0,0773201 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,0448945 0,07726479 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,0448945 0,07720956 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,0448945 0,07715441 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0448945 0,07709934 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,0448945 0,07704435 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 0,000 0,0448945 0,07698943 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 23 10 0,000 0,0448945 0,0769346 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0448945 0,07687984 ! blastocyst formation GO:0001825 17 10 0,000 0,0448945 0,07682516 ! cerebellar cortex development GO:0021695 15 10 0,000 0,0448945 0,07677056 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,0448945 0,07671603 ! activation of innate immune response GO:0002218 12 10 0,000 0,0448945 0,07666159 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,0448945 0,07660722 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,0448945 0,07655292 ! establishment of cell polarity GO:0030010 16 10 0,000 0,0448945 0,07649871 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,0448945 0,07644457 ! regulation of transcription factor activity GO:0051090 126 74 1,000 0,04543959 0,07731801 GO:0090046|regulation of transcription regulator activity, ! organelle localization GO:0051640 136 74 1,000 0,04543959 0,07726337 ! phosphoinositide-mediated signaling GO:0048015 131 75 1,000 0,04654763 0,07909152 ! rhythmic process GO:0048511 128 75 1,000 0,04654763 0,0790357 ! development of primary sexual characteristics GO:0045137 124 76 1,000 0,04766555 0,0808768 ! positive regulation of ligase activity GO:0051351 124 77 1,000 0,04879325 0,08273189 ! negative regulation of muscle development GO:0048635 20 11 0,000 0,04927238 0,08348545 ! respiratory burst GO:0045730 17 11 0,000 0,04927238 0,0834267 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,04927238 0,08336803 ! telencephalon cell migration GO:0022029 20 11 0,000 0,04927238 0,08330944 ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,04927238 0,08325094 ! thyroid gland development GO:0030878 26 11 0,000 0,04927238 0,08319252 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,04927238 0,08313418 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,04927238 0,08307592 ! response to pain GO:0048265 24 11 0,000 0,04927238 0,08301774 ! T cell proliferation GO:0042098 26 11 0,000 0,04927238 0,08295965 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 0,000 0,04927238 0,08290163 GO:0010812|negative regulation of cell-substrate adhesion, ! bone resorption GO:0045453 16 11 0,000 0,04927238 0,0828437 ! peptide or protein amino-terminal blocking GO:0018409 21 11 0,000 0,04927238 0,08278585 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,04927238 0,08272808 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,04927238 0,08267039 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,04927238 0,08261278 ! melanocyte differentiation GO:0030318 21 11 0,000 0,04927238 0,08255525 GO:0050931|pigment cell differentiation, ! syncytium formation GO:0006949 18 11 0,000 0,04927238 0,0824978 ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,04927238 0,08244043 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,04927238 0,08238314 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,04927238 0,08232593 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 18 11 0,000 0,04927238 0,0822688 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,04927238 0,08221174 ! UV protection GO:0009650 19 11 0,000 0,04927238 0,08215477 ! adult heart development GO:0007512 14 11 0,000 0,04927238 0,08209788 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,04927238 0,08204106 ! temperature homeostasis GO:0001659 17 11 0,000 0,04927238 0,08198433 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,04927238 0,08192767 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,04927238 0,08187109 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,04927238 0,08181459 ! regulation of organ growth GO:0046620 13 11 0,000 0,04927238 0,08175816 ! pigment granule localization GO:0051875 20 11 0,000 0,04927238 0,08170182 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,04927238 0,08164555 ! vasoconstriction GO:0042310 18 11 0,000 0,04927238 0,08158936 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,04927238 0,08153324 ! embryonic axis specification GO:0000578 18 11 0,000 0,04927238 0,08147721 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,04927238 0,08142125 ! snRNA metabolic process GO:0016073 24 11 0,000 0,04927238 0,08136536 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,04927238 0,08130956 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,04927238 0,08125383 GO:0006809|nitric oxide biosynthetic process, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,04927238 0,08119817 ! zymogen activation GO:0031638 15 11 0,000 0,04927238 0,0811426 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,04927238 0,0810871 ! neuroblast proliferation GO:0007405 24 11 0,000 0,04927238 0,08103167 ! nucleosome positioning GO:0016584 15 11 0,000 0,04927238 0,08097632 ! regulation of isotype switching GO:0045191 22 11 0,000 0,04927238 0,08092105 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,04927238 0,08086585 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,04927238 0,08081073 ! acid secretion GO:0046717 18 11 0,000 0,04927238 0,08075568 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,04927238 0,0807007 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,04927238 0,08064581 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,04927238 0,08059098 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,04927238 0,08053623 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,04927238 0,08048156 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 19 11 0,000 0,04927238 0,08042696 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,04927238 0,08037243 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,04927238 0,08031798 ! germ cell migration GO:0008354 25 11 0,000 0,04927238 0,0802636 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,04927238 0,08020929 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,04927238 0,08015506 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,04927238 0,0801009 ! defense response to fungus GO:0050832 13 11 0,000 0,04927238 0,08004682 ! developmental induction GO:0031128 19 11 0,000 0,04927238 0,0799928 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,04927238 0,07993886 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,04927238 0,079885 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,04927238 0,0798312 ! sequestering of metal ion GO:0051238 14 11 0,000 0,04927238 0,07977748 ! lamellipodium assembly GO:0030032 20 11 0,000 0,04927238 0,07972383 ! regulation of embryonic development GO:0045995 27 11 0,000 0,04927238 0,07967025 ! nucleus localization GO:0051647 19 11 0,000 0,04927238 0,07961675 ! regulation of synapse organization GO:0050807 17 11 0,000 0,04927238 0,07956331 ! negative regulation of organelle organization GO:0010639 161 78 1,000 0,04993061 0,08057213 ! protein oligomerization GO:0051259 139 78 1,000 0,04993061 0,08051813 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 1,000 0,05107753 0,08231248 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,05107753 0,08225739 ! response to metal ion GO:0010038 140 80 1,000 0,05223389 0,08406337 ! muscle cell differentiation GO:0042692 159 80 1,000 0,05223389 0,08400718 ! digestion GO:0007586 112 81 1,000 0,05339959 0,08582459 ! intracellular protein transmembrane transport GO:0065002 153 81 1,000 0,05339959 0,0857673 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,05363032 0,08608043 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,05363032 0,08602304 ! positive regulation of cellular catabolic process GO:0031331 31 12 0,000 0,05363032 0,08596573 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,05363032 0,0859085 ! virus-host interaction GO:0019048 29 12 0,000 0,05363032 0,08585134 ! regulation of B cell proliferation GO:0030888 20 12 0,000 0,05363032 0,08579426 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,05363032 0,08573725 ! mating GO:0007618 17 12 0,000 0,05363032 0,08568032 ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,05363032 0,08562346 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,05363032 0,08556668 ! hippocampus development GO:0021766 26 12 0,000 0,05363032 0,08550998 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,05363032 0,08545335 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,05363032 0,0853968 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,05363032 0,08534032 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,05363032 0,08528391 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,05363032 0,08522758 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,05363032 0,08517133 ! drug transport GO:0015893 16 12 0,000 0,05363032 0,08511514 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,05363032 0,08505904 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,05363032 0,085003 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,05363032 0,08494704 ! polyamine metabolic process GO:0006595 17 12 0,000 0,05363032 0,08489116 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,05363032 0,08483534 ! forebrain cell migration GO:0021885 21 12 0,000 0,05363032 0,08477961 ! asymmetric protein localization GO:0008105 20 12 0,000 0,05363032 0,08472394 ! membrane protein proteolysis GO:0033619 25 12 0,000 0,05363032 0,08466835 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,05363032 0,08461283 ! entry into host cell GO:0030260 32 12 0,000 0,05363032 0,08455738 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,05363032 0,084502 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05363032 0,0844467 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,05363032 0,08439147 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,05363032 0,08433631 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,05363032 0,08428123 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,05363032 0,08422621 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,05363032 0,08417127 ! protein homotetramerization GO:0051289 21 12 0,000 0,05363032 0,0841164 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,05363032 0,0840616 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,05363032 0,08400687 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05363032 0,08395222 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,05363032 0,08389763 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,05363032 0,08384312 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,05363032 0,08378868 ! fucose catabolic process GO:0019317 22 12 0,000 0,05363032 0,0837343 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,05363032 0,08368 ! histone acetylation GO:0016573 26 12 0,000 0,05363032 0,08362577 ! histone methylation GO:0016571 26 12 0,000 0,05363032 0,08357161 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,05363032 0,08351751 ! autonomic nervous system development GO:0048483 24 12 0,000 0,05363032 0,08346349 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,05363032 0,08340954 ! peptidyl-lysine modification GO:0018205 21 12 0,000 0,05363032 0,08335566 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,05363032 0,08330185 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,05363032 0,0832481 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,05363032 0,08319443 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,05363032 0,08314082 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,05363032 0,08308729 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,05363032 0,08303382 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,05363032 0,08298042 ! response to cold GO:0009409 17 12 0,000 0,05363032 0,08292709 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,05363032 0,08287383 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,05363032 0,08282064 ! regulation of ligase activity GO:0051340 142 84 1,000 0,05695162 0,08789327 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,05695162 0,08783692 ! cGMP metabolic process GO:0046068 18 13 0,000 0,05796844 0,0893479 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,05796844 0,0892907 ! regulation of chemokine production GO:0032642 18 13 0,000 0,05796844 0,08923357 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,05796844 0,08917651 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,05796844 0,08911953 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,05796844 0,08906262 ! lipid localization GO:0010876 28 13 0,000 0,05796844 0,08900579 GO:0019915|lipid storage, ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,05796844 0,08894902 ! organelle fusion GO:0048284 32 13 0,000 0,05796844 0,08889233 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,05796844 0,08883571 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,05796844 0,08877917 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,05796844 0,08872269 ! endocrine pancreas development GO:0031018 22 13 0,000 0,05796844 0,08866629 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,05796844 0,08860996 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,05796844 0,08855369 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,05796844 0,08849751 ! methionine metabolic process GO:0006555 27 13 0,000 0,05796844 0,08844139 ! plasma membrane organization GO:0007009 24 13 0,000 0,05796844 0,08838534 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,05796844 0,08832937 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,05796844 0,08827346 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,05796844 0,08821763 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,05796844 0,08816186 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,05796844 0,08810617 ! cytokine metabolic process GO:0042107 22 13 0,000 0,05796844 0,08805055 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,05796844 0,087995 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 0,000 0,05796844 0,08793951 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,05796844 0,0878841 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,05796844 0,08782876 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,05796844 0,08777349 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,05796844 0,08771828 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,05796844 0,08766315 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,05796844 0,08760808 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,05796844 0,08755309 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,05796844 0,08749816 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,05796844 0,0874433 ! ribosome assembly GO:0042255 17 13 0,000 0,05796844 0,08738851 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,05796844 0,08733379 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,05796844 0,08727914 ! chromatin silencing GO:0006342 26 13 0,000 0,05796844 0,08722456 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,05796844 0,08717004 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,05796844 0,0871156 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,05796844 0,08706122 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,05796844 0,08700691 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,05796844 0,08695266 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,05796844 0,08689849 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,05796844 0,08684438 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,05796844 0,08679034 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,05796844 0,08673636 ! embryonic placenta development GO:0001892 23 13 0,000 0,05796844 0,08668245 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,05796844 0,08662861 ! insulin secretion GO:0030073 23 13 0,000 0,05796844 0,08657484 ! actin filament polymerization GO:0030041 24 13 0,000 0,05796844 0,08652113 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,05796844 0,08646749 ! acrosome reaction GO:0007340 18 13 0,000 0,05796844 0,08641392 ! one-carbon metabolic process GO:0006730 154 85 1,000 0,05815359 0,08663624 ! response to inorganic substance GO:0010035 153 86 1,000 0,05936435 0,08838529 ! amine biosynthetic process GO:0009309 138 86 1,000 0,05936435 0,08833063 ! regulation of DNA binding GO:0051101 155 88 1,000 0,06181187 0,09191555 ! regulation of neurological system process GO:0031644 148 88 1,000 0,06181187 0,09185878 ! rRNA transcription GO:0009303 25 14 0,000 0,06228682 0,09250746 ! lactation GO:0007595 26 14 0,000 0,06228682 0,09245039 ! N-terminal protein amino acid modification GO:0031365 27 14 0,000 0,06228682 0,09239339 ! reproductive cellular process GO:0048610 20 14 0,000 0,06228682 0,09233646 ! tRNA modification GO:0006400 20 14 0,000 0,06228682 0,09227961 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,06228682 0,09222282 ! regulation of S phase GO:0033261 23 14 0,000 0,06228682 0,0921661 ! water transport GO:0006833 21 14 0,000 0,06228682 0,09210945 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 25 14 0,000 0,06228682 0,09205287 ! non-recombinational repair GO:0000726 25 14 0,000 0,06228682 0,09199637 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,06228682 0,09193993 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,06228682 0,09188356 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,06228682 0,09182725 ! RNA polyadenylation GO:0043631 30 14 0,000 0,06228682 0,09177102 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,06228682 0,09171486 ! palate development GO:0060021 31 14 0,000 0,06228682 0,09165876 ! regulated secretory pathway GO:0045055 23 14 0,000 0,06228682 0,09160274 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,06228682 0,09154678 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,06228682 0,09149089 ! arginine metabolic process GO:0006525 17 14 0,000 0,06228682 0,09143507 ! regulation of heart rate GO:0002027 24 14 0,000 0,06228682 0,09137932 ! organic alcohol transport GO:0015850 29 14 0,000 0,06228682 0,09132363 ! actin cytoskeleton reorganization GO:0031532 33 14 0,000 0,06228682 0,09126801 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,06228682 0,09121246 ! embryo implantation GO:0007566 30 14 0,000 0,06228682 0,09115698 ! neutral amino acid transport GO:0015804 26 14 0,000 0,06228682 0,09110157 ! L-amino acid transport GO:0015807 30 14 0,000 0,06228682 0,09104622 ! bone mineralization GO:0030282 17 14 0,000 0,06228682 0,09099094 ! stem cell development GO:0048864 43 14 0,000 0,06228682 0,09093573 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,06228682 0,09088058 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,06228682 0,0908255 ! cerebellum development GO:0021549 21 14 0,000 0,06228682 0,09077049 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,06228682 0,09071554 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,06228682 0,09066066 ! cofactor transport GO:0051181 26 14 0,000 0,06228682 0,09060585 ! NADP metabolic process GO:0006739 24 14 0,000 0,06228682 0,09055111 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,06228682 0,09049642 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,06228682 0,09044181 ! intestinal absorption GO:0050892 25 14 0,000 0,06228682 0,09038726 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,06228682 0,09033278 ! oxygen transport GO:0015671 21 14 0,000 0,06228682 0,09027836 ! male genitalia development GO:0030539 24 14 0,000 0,06228682 0,09022401 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,06228682 0,09016972 ! cellular defense response GO:0006968 114 89 1,000 0,06304841 0,09121737 ! sex differentiation GO:0007548 145 90 1,000 0,06429335 0,09296262 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,06658554 0,0962191 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! superoxide anion generation GO:0042554 20 15 0,000 0,06658554 0,09616135 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,06658554 0,09610366 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,06658554 0,09604605 ! copper ion transport GO:0006825 20 15 0,000 0,06658554 0,0959885 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,06658554 0,09593102 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,06658554 0,09587361 ! sulfate transport GO:0008272 23 15 0,000 0,06658554 0,09581627 ! response to cAMP GO:0051591 22 15 0,000 0,06658554 0,095759 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,06658554 0,09570179 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,06658554 0,09564466 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,06658554 0,09558759 ! regulation of transmembrane transporter activity GO:0022898 27 15 0,000 0,06658554 0,09553059 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,06658554 0,09547366 ! response to hexose stimulus GO:0009746 22 15 0,000 0,06658554 0,0954168 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,06658554 0,09536 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,06658554 0,09530327 ! pituitary gland development GO:0021983 29 15 0,000 0,06658554 0,09524661 ! vesicle coating GO:0006901 33 15 0,000 0,06658554 0,09519002 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,06658554 0,09513349 ! regulation of exocytosis GO:0017157 22 15 0,000 0,06658554 0,09507703 ! intermediate filament cytoskeleton organization GO:0045104 31 15 0,000 0,06658554 0,09502064 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,06658554 0,09496432 ! regulation of vasodilation GO:0042312 26 15 0,000 0,06658554 0,09490806 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,06658554 0,09485187 ! histone deacetylation GO:0016575 20 15 0,000 0,06658554 0,09479574 ! mRNA splice site selection GO:0006376 38 15 0,000 0,06658554 0,09473968 ! tissue regeneration GO:0042246 26 15 0,000 0,06658554 0,09468369 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,06658554 0,09462776 ! water homeostasis GO:0030104 27 15 0,000 0,06658554 0,0945719 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,06658554 0,09451611 ! muscle maintenance GO:0046716 26 15 0,000 0,06658554 0,09446038 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,06658554 0,09440472 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,06658554 0,09434912 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,06658554 0,09429359 ! heme biosynthetic process GO:0006783 29 15 0,000 0,06658554 0,09423812 ! detection of bacterium GO:0016045 18 15 0,000 0,06658554 0,09418272 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,06658554 0,09412738 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,06658554 0,09407211 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,06658554 0,0940169 ! peptide hormone processing GO:0016486 23 15 0,000 0,06658554 0,09396176 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 1,000 0,06807746 0,09601077 GO:0010498|proteasomal protein catabolic process, ! biogenic amine metabolic process GO:0006576 155 94 1,000 0,06935494 0,09775511 ! female pregnancy GO:0007565 164 94 1,000 0,06935494 0,09769788 ! transcription initiation GO:0006352 153 94 1,000 0,06935494 0,09764071 ! regulation of T cell activation GO:0050863 158 94 1,000 0,06935494 0,09758361 ! forebrain development GO:0030900 188 95 1,000 0,0706403 0,09933405 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,0708647 0,09959139 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,0708647 0,09953325 ! G1 phase of mitotic cell cycle GO:0000080 35 16 0,000 0,0708647 0,09947518 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,0708647 0,09941718 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,0708647 0,09935924 ! embryonic forelimb morphogenesis GO:0035115 28 16 0,000 0,0708647 0,09930137 ! bone remodeling GO:0046849 27 16 0,000 0,0708647 0,09924357 ! filopodium assembly GO:0046847 32 16 0,000 0,0708647 0,09918584 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 0,000 0,0708647 0,09912817 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,0708647 0,09907057 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,0708647 0,09901304 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,0708647 0,09895558 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,0708647 0,09889818 ! startle response GO:0001964 28 16 0,000 0,0708647 0,09884084 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,0708647 0,09878358 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,0708647 0,09872638 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,0708647 0,09866925 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,0708647 0,09861218 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,0708647 0,09855518 ! protein polyubiquitination GO:0000209 34 16 0,000 0,0708647 0,09849824 ! glutamate metabolic process GO:0006536 22 16 0,000 0,0708647 0,09844137 ! response to osmotic stress GO:0006970 25 16 0,000 0,0708647 0,09838457 ! lysosomal transport GO:0007041 26 16 0,000 0,0708647 0,09832783 ! fructose metabolic process GO:0006000 25 16 0,000 0,0708647 0,09827116 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,0708647 0,09821455 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 32 16 0,000 0,0708647 0,09815801 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,0708647 0,09810153 ! axon cargo transport GO:0008088 43 16 0,000 0,0708647 0,09804512 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,0708647 0,09798877 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,0708647 0,09793248 ! DNA replication initiation GO:0006270 27 16 0,000 0,0708647 0,09787627 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,0708647 0,09782011 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,0708647 0,09776402 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,0708647 0,097708 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,0708647 0,09765204 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,0708647 0,09759614 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,0708647 0,09754031 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,0708647 0,09748454 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,0708647 0,09742883 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,0708647 0,09737319 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,0708647 0,09731761 ! mRNA transport GO:0051028 169 96 1,000 0,07193345 0,09872897 ! detection of stimulus GO:0051606 151 96 1,000 0,07193345 0,09867268 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,07512438 0,10299103 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,07512438 0,10293237 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,07512438 0,10287379 ! negative regulation of cell cycle process GO:0010948 32 17 0,000 0,07512438 0,10281527 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,07512438 0,10275682 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,07512438 0,10269844 ! signal complex assembly GO:0007172 41 17 0,000 0,07512438 0,10264012 ! endothelial cell migration GO:0043542 28 17 0,000 0,07512438 0,10258187 ! inositol metabolic process GO:0006020 28 17 0,000 0,07512438 0,10252368 ! gene silencing by RNA GO:0031047 36 17 0,000 0,07512438 0,10246556 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,07512438 0,10240751 ! glial cell development GO:0021782 27 17 0,000 0,07512438 0,10234952 ! limbic system development GO:0021761 36 17 0,000 0,07512438 0,1022916 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,07512438 0,10223374 ! adult walking behavior GO:0007628 33 17 0,000 0,07512438 0,10217595 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,07512438 0,10211822 ! heart looping GO:0001947 30 17 0,000 0,07512438 0,10206056 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,07512438 0,10200296 ! myoblast differentiation GO:0045445 45 17 0,000 0,07512438 0,10194543 ! cardiac muscle tissue development GO:0048738 31 17 0,000 0,07512438 0,10188796 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,07512438 0,10183056 ! glycine metabolic process GO:0006544 28 17 0,000 0,07512438 0,10177323 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,07512438 0,10171595 ! NAD metabolic process GO:0019674 29 17 0,000 0,07512438 0,10165875 ! membrane budding GO:0006900 37 17 0,000 0,07512438 0,1016016 ! DNA integration GO:0015074 29 17 0,000 0,07512438 0,10154452 ! negative regulation of protein catabolic process GO:0042177 40 17 0,000 0,07512438 0,10148751 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,07512438 0,10143056 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,07512438 0,10137367 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,07512438 0,10131684 ! genitalia development GO:0048806 30 17 0,000 0,07512438 0,10126008 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,07512438 0,10120339 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 0,000 0,07512438 0,10114675 ! negative regulation of blood coagulation GO:0030195 24 17 0,000 0,07512438 0,10109018 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,07512438 0,10103368 ! steroid catabolic process GO:0006706 31 17 0,000 0,07512438 0,10097723 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,07512438 0,10092085 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,07512438 0,10086454 ! gas transport GO:0015669 25 17 0,000 0,07512438 0,10080828 ! organic cation transport GO:0015695 31 17 0,000 0,07512438 0,10075209 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,07512438 0,10069596 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,07512438 0,10063989 ! microspike assembly GO:0030035 36 17 0,000 0,07512438 0,10058389 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,07512438 0,10052795 ! skeletal muscle tissue development GO:0007519 186 99 1,000 0,07585867 0,10145412 GO:0060538|skeletal muscle organ development, ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,07936467 0,10608411 ! neuron maturation GO:0042551 42 18 0,000 0,07936467 0,10602521 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,07936467 0,10596637 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,07936467 0,1059076 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,07936467 0,10584889 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,07936467 0,10579025 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,07936467 0,10573167 ! memory GO:0007613 31 18 0,000 0,07936467 0,10567316 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,07936467 0,10561471 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,07936467 0,10555633 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,07936467 0,10549801 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,07936467 0,10543975 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,07936467 0,10538157 ! glutamine metabolic process GO:0006541 29 18 0,000 0,07936467 0,10532344 ! response to retinoic acid GO:0032526 26 18 0,000 0,07936467 0,10526538 ! response to fungus GO:0009620 21 18 0,000 0,07936467 0,10520738 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,07936467 0,10514945 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,07936467 0,10509158 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,07936467 0,10503377 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,07936467 0,10497603 ! vitamin transport GO:0051180 27 18 0,000 0,07936467 0,10491835 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,07936467 0,10486073 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,07936467 0,10480318 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 0,000 0,07936467 0,10474569 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,07936467 0,10468827 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,07936467 0,1046309 ! protein secretion GO:0009306 39 19 0,000 0,08358566 0,11013533 ! positive regulation of translation GO:0045727 30 19 0,000 0,08358566 0,11007504 ! negative regulation of defense response GO:0031348 25 19 0,000 0,08358566 0,11001483 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,08358566 0,10995468 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,08358566 0,10989459 ! skin development GO:0043588 36 19 0,000 0,08358566 0,10983457 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,08358566 0,10977462 ! forelimb morphogenesis GO:0035136 32 19 0,000 0,08358566 0,10971473 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,08358566 0,10965491 ! mitotic chromosome condensation GO:0007076 34 19 0,000 0,08358566 0,10959515 ! cerebral cortex development GO:0021987 36 19 0,000 0,08358566 0,10953546 ! pigmentation during development GO:0048066 41 19 0,000 0,08358566 0,10947583 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,08358566 0,10941627 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 0,000 0,08358566 0,10935677 ! heme metabolic process GO:0042168 36 19 0,000 0,08358566 0,10929734 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,08358566 0,10923797 ! plasma membrane fusion GO:0045026 28 19 0,000 0,08358566 0,10917867 ! peptide cross-linking GO:0018149 37 19 0,000 0,08358566 0,10911943 ! protein export from nucleus GO:0006611 36 19 0,000 0,08358566 0,10906025 ! heart process GO:0003015 30 19 0,000 0,08358566 0,10900114 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,08358566 0,10894209 GO:0006692|prostanoid metabolic process, ! G1 phase GO:0051318 40 19 0,000 0,08358566 0,10888311 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,08358566 0,10882419 ! cell-cell junction organization GO:0045216 35 19 0,000 0,08358566 0,10876534 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,08358566 0,10870654 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,08358566 0,10864782 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,08358566 0,10858915 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,08358566 0,10853055 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,08358566 0,10847201 ! cilium assembly GO:0042384 37 19 0,000 0,08358566 0,10841353 ! peptide hormone secretion GO:0030072 31 19 0,000 0,08358566 0,10835512 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,08778744 0,11374076 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 0,000 0,08778744 0,11367954 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,08778744 0,11361839 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,08778744 0,11355731 ! protein amino acid acetylation GO:0006473 39 20 0,000 0,08778744 0,11349629 ! cAMP metabolic process GO:0046058 36 20 0,000 0,08778744 0,11343533 ! response to vitamin GO:0033273 31 20 0,000 0,08778744 0,11337444 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,08778744 0,11331362 ! regulation of carbohydrate metabolic process GO:0006109 38 20 0,000 0,08778744 0,11325286 GO:0010675|regulation of cellular carbohydrate metabolic process, ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,08778744 0,11319217 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,08778744 0,11313154 ! retinoid metabolic process GO:0001523 32 20 0,000 0,08778744 0,11307098 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,08778744 0,11301048 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,08778744 0,11295005 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,08778744 0,11288968 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,08778744 0,11282937 GO:0032392|DNA geometric change, ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,08778744 0,11276913 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,08778744 0,11270896 ! body fluid secretion GO:0007589 31 20 0,000 0,08778744 0,11264885 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,08778744 0,1125888 ! peptide secretion GO:0002790 35 20 0,000 0,08778744 0,11252882 ! stem cell differentiation GO:0048863 53 20 0,000 0,08778744 0,1124689 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,08778744 0,11240904 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,08778744 0,11234925 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,08778744 0,11228952 ! sensory perception of pain GO:0019233 30 20 0,000 0,08778744 0,11222986 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,08778744 0,11217025 ! diencephalon development GO:0021536 34 20 0,000 0,08778744 0,11211072 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,08778744 0,11205124 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,08778744 0,11199183 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,08778744 0,11193248 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,08778744 0,11187319 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,08778744 0,11181397 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,08778744 0,11175481 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,08778744 0,11169571 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,08778744 0,11163667 ! actin filament-based movement GO:0030048 43 20 0,000 0,08778744 0,1115777 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,08778744 0,11151879 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,08778744 0,11145994 ! negative regulation of translation GO:0017148 29 20 0,000 0,08778744 0,11140115 ! negative regulation of coagulation GO:0050819 29 20 0,000 0,08778744 0,11134243 ! regulation of cell killing GO:0031341 42 21 0,000 0,0919701 0,11658591 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,0919701 0,11652452 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,0919701 0,11646319 ! hormone secretion GO:0046879 38 21 0,000 0,0919701 0,11640192 ! glycerol metabolic process GO:0006071 34 21 0,000 0,0919701 0,11634072 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,0919701 0,11627959 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,0919701 0,11621852 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,0919701 0,11615751 ! axis specification GO:0009798 38 21 0,000 0,0919701 0,11609657 ! smooth muscle contraction GO:0006939 46 21 0,000 0,0919701 0,11603569 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,0919701 0,11597487 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,0919701 0,11591412 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 0,000 0,0919701 0,11585343 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,0919701 0,11579281 ! cytolysis GO:0019835 24 21 0,000 0,0919701 0,11573225 ! vasodilation GO:0042311 39 21 0,000 0,0919701 0,11567175 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,0919701 0,11561131 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,0919701 0,11555094 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,0919701 0,11549063 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,0919701 0,11543039 ! negative regulation of intracellular transport GO:0032387 41 21 0,000 0,0919701 0,11537021 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,0919701 0,11531009 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,0919701 0,11525003 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,0919701 0,11519003 ! sperm-egg recognition GO:0035036 21 21 0,000 0,0919701 0,1151301 ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,09613371 0,12027962 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,09613371 0,1202171 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,09613371 0,12015465 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,09613371 0,12009227 ! microtubule-based transport GO:0010970 54 22 0,000 0,09613371 0,12002995 ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,09613371 0,11996769 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,09613371 0,1199055 ! keratinization GO:0031424 28 22 0,000 0,09613371 0,11984337 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,09613371 0,11978131 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,09613371 0,11971931 ! sensory perception of taste GO:0050909 28 22 0,000 0,09613371 0,11965738 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,09613371 0,11959551 ! vacuolar transport GO:0007034 36 22 0,000 0,09613371 0,1195337 ! lysosome organization GO:0007040 41 22 0,000 0,09613371 0,11947196 ! central nervous system neuron development GO:0021954 46 22 0,000 0,09613371 0,11941028 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,09613371 0,11934866 ! fucose metabolic process GO:0006004 39 22 0,000 0,09613371 0,11928711 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,09613371 0,11922562 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,09613371 0,1191642 GO:0060415|muscle tissue morphogenesis, ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,09613371 0,11910284 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,09613371 0,11904154 ! sarcomere organization GO:0045214 30 22 0,000 0,09613371 0,1189803 ! positive regulation of B cell activation GO:0050871 38 22 0,000 0,09613371 0,11891913 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,09613371 0,11885802 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,09613371 0,11879697 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,09613371 0,11873599 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 0,000 0,09613371 0,11867507 ! protein stabilization GO:0050821 39 22 0,000 0,09613371 0,11861421 ! positive regulation of DNA replication GO:0045740 43 23 0,000 0,10027837 0,12366467 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,10027837 0,12360131 ! myeloid leukocyte differentiation GO:0002573 40 23 0,000 0,10027837 0,12353802 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,10027837 0,1234748 ! gluconeogenesis GO:0006094 33 23 0,000 0,10027837 0,12341164 ! viral genome replication GO:0019079 41 23 0,000 0,10027837 0,12334855 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,10027837 0,12328552 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,10027837 0,12322255 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,10027837 0,12315965 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,10027837 0,12309682 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,10027837 0,12303404 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,10027837 0,12297134 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,10027837 0,12290869 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,10027837 0,12284611 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,10027837 0,12278359 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,10027837 0,12272114 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,10027837 0,12265875 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,10027837 0,12259642 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,10027837 0,12253416 GO:0051693|actin filament capping, ! sex determination GO:0007530 47 23 0,000 0,10027837 0,12247196 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,10027837 0,12240982 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,10027837 0,12234775 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,10027837 0,12228574 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,10027837 0,12222379 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,10027837 0,1221619 ! fatty acid transport GO:0015908 44 23 0,000 0,10027837 0,12210008 ! platelet activation GO:0030168 37 23 0,000 0,10027837 0,12203832 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,10027837 0,12197662 ! hormone transport GO:0009914 40 23 0,000 0,10027837 0,12191499 ! cell-cell recognition GO:0009988 25 23 0,000 0,10027837 0,12185341 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,10027837 0,1217919 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,10027837 0,12173045 ! negative regulation of catabolic process GO:0009895 50 23 0,000 0,10027837 0,12166907 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,10027837 0,12160774 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,10027837 0,12154648 ! positive regulation of fibroblast proliferation GO:0048146 43 24 0,000 0,10440416 0,12648359 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,10440416 0,12641994 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 52 24 0,000 0,10440416 0,12635635 ! regulation of transmembrane transport GO:0034762 38 24 0,000 0,10440416 0,12629282 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,10440416 0,12622936 ! vesicle docking GO:0048278 47 24 0,000 0,10440416 0,12616596 ! vacuole organization GO:0007033 43 24 0,000 0,10440416 0,12610262 ! digestive system process GO:0022600 39 24 0,000 0,10440416 0,12603935 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,10440416 0,12597614 ! regulation of alpha-beta T cell activation GO:0046634 42 24 0,000 0,10440416 0,12591299 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,10440416 0,12584991 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,10440416 0,12578689 ! membrane depolarization GO:0051899 39 24 0,000 0,10440416 0,12572393 ! pallium development GO:0021543 49 24 0,000 0,10440416 0,12566104 ! pentose metabolic process GO:0019321 35 24 0,000 0,10440416 0,12559821 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,10440416 0,12553544 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,10440416 0,12547274 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,10440416 0,12541009 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,10440416 0,12534751 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,10440416 0,125285 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,10440416 0,12522254 ! regulation of amine transport GO:0051952 40 24 0,000 0,10440416 0,12516015 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,10851117 0,13001887 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 0,000 0,10851117 0,12995415 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,10851117 0,12988949 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,10851117 0,1298249 ! phototransduction GO:0007602 33 25 0,000 0,10851117 0,12976038 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,10851117 0,12969592 GO:0006479|protein amino acid methylation, ! sperm motility GO:0030317 31 25 0,000 0,10851117 0,12963152 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,10851117 0,12956719 ! receptor metabolic process GO:0043112 46 25 0,000 0,10851117 0,12950292 ! chromosome condensation GO:0030261 45 25 0,000 0,10851117 0,12943871 ! osteoblast differentiation GO:0001649 60 25 0,000 0,10851117 0,12937457 ! neural crest cell development GO:0014032 54 25 0,000 0,10851117 0,12931049 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,10851117 0,12924648 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,10851117 0,12918252 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,10851117 0,12911864 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,10851117 0,12905481 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! somitogenesis GO:0001756 43 25 0,000 0,10851117 0,12899105 ! immunoglobulin production GO:0002377 55 25 0,000 0,10851117 0,12892735 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,10851117 0,12886371 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,10851117 0,12880014 ! regulation of blood coagulation GO:0030193 40 25 0,000 0,10851117 0,12873663 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,10851117 0,12867318 ! telomere organization GO:0032200 43 25 0,000 0,10851117 0,12860979 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 0,000 0,10851117 0,12854647 GO:0060606|tube closure, ! liver development GO:0001889 53 25 0,000 0,10851117 0,12848321 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,11259948 0,13325842 ! embryonic pattern specification GO:0009880 44 26 0,000 0,11259948 0,1331929 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,11259948 0,13312745 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,11259948 0,13306206 ! initiation of viral infection GO:0019059 57 26 0,000 0,11259948 0,13299674 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,11259948 0,13293148 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,11259948 0,13286629 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,11259948 0,13280116 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,11259948 0,13273609 ! tube lumen formation GO:0035148 50 26 0,000 0,11259948 0,13267109 ! regulation of transcription factor import into nucleus GO:0042990 54 26 0,000 0,11259948 0,13260615 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,11259948 0,13254127 GO:0051297|centrosome organization, ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 0,000 0,11259948 0,13247646 ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,11259948 0,13241171 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,11259948 0,13234702 ! positive regulation of nuclear division GO:0051785 40 26 0,000 0,11259948 0,1322824 GO:0045840|positive regulation of mitosis, ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,11259948 0,13221784 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,11259948 0,13215335 ! blastocyst development GO:0001824 49 26 0,000 0,11259948 0,13208891 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,11259948 0,13202454 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,11259948 0,13196023 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,11666918 0,13666312 ! iron ion transport GO:0006826 59 27 0,000 0,11666918 0,13659662 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,11666918 0,13653018 ! protein amino acid acylation GO:0043543 55 27 0,000 0,11666918 0,13646381 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,11666918 0,1363975 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,11666918 0,13633125 ! fat cell differentiation GO:0045444 50 27 0,000 0,11666918 0,13626507 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,11666918 0,13619896 ! autophagy GO:0006914 41 27 0,000 0,11666918 0,13613291 ! primary neural tube formation GO:0014020 51 27 0,000 0,11666918 0,13606692 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,11666918 0,13600099 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,11666918 0,13593513 ! glutathione metabolic process GO:0006749 39 27 0,000 0,11666918 0,13586934 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,11666918 0,1358036 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,11666918 0,13573794 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,11666918 0,13567233 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,12072035 0,14031554 ! circadian rhythm GO:0007623 50 28 0,000 0,12072035 0,14024778 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,12072035 0,1401801 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,12072035 0,14011248 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,12072035 0,14004492 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,12072035 0,13997743 ! positive regulation of T cell differentiation GO:0045582 42 28 0,000 0,12072035 0,13991 ! synaptogenesis GO:0007416 42 28 0,000 0,12072035 0,13984264 ! peptidyl-tyrosine modification GO:0018212 50 28 0,000 0,12072035 0,13977534 ! lipid oxidation GO:0034440 43 28 0,000 0,12072035 0,13970811 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,12072035 0,13964094 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,12072035 0,13957384 ! translational initiation GO:0006413 65 29 0,000 0,12475307 0,14416709 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,12475307 0,14409788 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,12475307 0,14402874 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,12475307 0,14395966 ! complement activation, classical pathway GO:0006958 48 29 0,000 0,12475307 0,14389065 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,12475307 0,1438217 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,12475307 0,14375282 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,12475307 0,14368401 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,12475307 0,14361526 ! cell fate determination GO:0001709 60 29 0,000 0,12475307 0,14354658 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,12475307 0,14347796 ! detection of light stimulus GO:0009583 38 29 0,000 0,12475307 0,14340941 ! regulation of coagulation GO:0050818 46 29 0,000 0,12475307 0,14334092 ! zinc ion transport GO:0006829 45 30 0,000 0,12876743 0,14788279 ! membrane docking GO:0022406 61 30 0,000 0,12876743 0,14781223 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,12876743 0,14774175 ! regulation of innate immune response GO:0045088 51 30 0,000 0,12876743 0,14767133 ! acute-phase response GO:0006953 49 30 0,000 0,12876743 0,14760097 ! myofibril assembly GO:0030239 47 30 0,000 0,12876743 0,14753069 GO:0055002|striated muscle cell development, ! negative regulation of protein kinase cascade GO:0010741 68 30 0,000 0,12876743 0,14746047 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,12876743 0,14739032 ! phospholipid transport GO:0015914 51 30 0,000 0,12876743 0,14732023 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,12876743 0,14725021 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,12876743 0,14718026 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,12876743 0,14711037 ! regulation of B cell activation GO:0050864 50 30 0,000 0,12876743 0,14704055 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,13276351 0,15153179 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,13276351 0,15145994 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,13276351 0,15138816 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,13276351 0,15131644 GO:0009799|determination of symmetry, ! inner ear morphogenesis GO:0042472 47 31 0,000 0,13276351 0,1512448 ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,13276351 0,15117322 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,13276351 0,15110171 ! positive regulation of T cell proliferation GO:0042102 52 31 0,000 0,13276351 0,15103027 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,13276351 0,15095889 ! peptide transport GO:0015833 55 31 0,000 0,13276351 0,15088758 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,13276351 0,15081634 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,13276351 0,15074517 ! natural killer cell activation GO:0030101 45 31 0,000 0,13276351 0,15067406 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,13276351 0,15060302 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,13276351 0,15053205 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,13276351 0,15046115 ! negative regulation of transcription regulator activity GO:0090048 58 31 0,000 0,13276351 0,15039031 GO:0043433|negative regulation of transcription factor activity, ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,13276351 0,15031954 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,1367414 0,15475061 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,1367414 0,15467786 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,1367414 0,15460517 ! cholesterol transport GO:0030301 56 32 0,000 0,1367414 0,15453255 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,1367414 0,15446 ! spliceosome assembly GO:0000245 67 32 0,000 0,1367414 0,15438752 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,1367414 0,15431511 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,1367414 0,15424276 ! muscle cell development GO:0055001 49 32 0,000 0,1367414 0,15417048 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,1367414 0,15409827 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,1367414 0,15402613 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,1367414 0,15395405 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 0,000 0,1367414 0,15388204 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,1367414 0,1538101 ! positive regulation of catabolic process GO:0009896 64 32 0,000 0,1367414 0,15373823 ! gene silencing GO:0016458 65 32 0,000 0,1367414 0,15366642 ! protein targeting to membrane GO:0006612 68 33 0,000 0,14070117 0,15804249 ! ceramide metabolic process GO:0006672 64 33 0,000 0,14070117 0,15796874 ! sterol transport GO:0015918 57 33 0,000 0,14070117 0,15789506 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,14070117 0,15782145 ! adult locomotory behavior GO:0008344 59 33 0,000 0,14070117 0,15774791 ! negative regulation of protein transport GO:0051224 69 33 0,000 0,14070117 0,15767443 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,14070117 0,15760103 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,14464291 0,16194082 ! glial cell differentiation GO:0010001 63 34 0,000 0,14464291 0,1618655 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,14464291 0,16179025 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,14464291 0,16171507 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,14464291 0,16163996 ! mismatch repair GO:0006298 46 34 0,000 0,14464291 0,16156492 ! spermatid development GO:0007286 63 34 0,000 0,14464291 0,16148995 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,14464291 0,16141504 ! placenta development GO:0001890 53 34 0,000 0,14464291 0,16134021 ! negative regulation of secretion GO:0051048 63 35 0,000 0,14856669 0,16564016 ! negative regulation of cell adhesion GO:0007162 81 35 0,000 0,14856669 0,16556344 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,14856669 0,16548679 GO:0006639|acylglycerol metabolic process, ! cytokine production GO:0001816 59 35 0,000 0,14856669 0,16541021 ! vesicle localization GO:0051648 64 35 0,000 0,14856669 0,1653337 ! mitotic sister chromatid segregation GO:0000070 57 36 0,000 0,15247261 0,16960199 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 0,000 0,15247261 0,16952361 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,15247261 0,16944531 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,15247261 0,16936708 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,15247261 0,16928892 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,15247261 0,16921084 ! regulation of proteolysis GO:0030162 72 36 0,000 0,15247261 0,16913283 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,15247261 0,16905488 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,15247261 0,16897702 ! aerobic respiration GO:0009060 55 36 0,000 0,15247261 0,16889922 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,15247261 0,16882149 ! RNA export from nucleus GO:0006405 56 37 0,000 0,15636074 0,17304689 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,15636074 0,17296733 ! meiosis I GO:0007127 65 37 0,000 0,15636074 0,17288784 ! establishment or maintenance of cell polarity GO:0007163 83 37 0,000 0,15636074 0,17280842 ! sister chromatid segregation GO:0000819 58 37 0,000 0,15636074 0,17272908 ! actomyosin structure organization GO:0031032 62 37 0,000 0,15636074 0,17264981 ! organic anion transport GO:0015711 68 37 0,000 0,15636074 0,17257061 ! negative regulation of DNA binding GO:0043392 68 37 0,000 0,15636074 0,17249149 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,15636074 0,17241244 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,15636074 0,17233346 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,15636074 0,17225455 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 66 37 0,000 0,15636074 0,17217571 ! positive regulation of DNA metabolic process GO:0051054 72 38 0,000 0,16023116 0,17635689 ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,16023116 0,17627625 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,16023116 0,17619569 ! carbohydrate homeostasis GO:0033500 53 38 0,000 0,16023116 0,1761152 GO:0042593|glucose homeostasis, ! nucleotide catabolic process GO:0009166 61 38 0,000 0,16023116 0,17603478 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,16023116 0,17595443 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,16023116 0,17587416 ! positive regulation of leukocyte proliferation GO:0070665 62 38 0,000 0,16023116 0,17579397 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mRNA catabolic process GO:0006402 71 39 0,000 0,16408395 0,17993892 ! organic ether metabolic process GO:0018904 55 39 0,000 0,16408395 0,17985694 ! segmentation GO:0035282 67 39 0,000 0,16408395 0,17977504 ! ion transmembrane transport GO:0034220 66 39 0,000 0,16408395 0,17969321 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,16408395 0,17961146 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,16408395 0,17952978 ! RNA modification GO:0009451 57 39 0,000 0,16408395 0,17944817 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,16408395 0,17936664 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,16791919 0,18347574 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,16791919 0,18339245 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,16791919 0,18330924 ! feeding behavior GO:0007631 59 40 0,000 0,16791919 0,18322611 ! negative regulation of binding GO:0051100 72 40 0,000 0,16791919 0,18314305 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,16791919 0,18306007 ! maintenance of protein location GO:0045185 91 40 0,000 0,16791919 0,18297716 ! cytokinesis GO:0000910 72 40 0,000 0,16791919 0,18289433 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,17173696 0,18696793 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,17173696 0,18688337 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,17173696 0,18679889 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 0,000 0,17173696 0,18671448 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,17173696 0,18663014 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,17173696 0,18654588 ! polyol metabolic process GO:0019751 66 41 0,000 0,17173696 0,1864617 ! positive regulation of transcription factor activity GO:0051091 62 42 0,000 0,17553735 0,19050196 GO:0090047|positive regulation of transcription regulator activity, ! regulation of tube size GO:0035150 71 42 0,000 0,17553735 0,19041608 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,17553735 0,19033026 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 0,000 0,17553735 0,19024453 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,17553735 0,19015887 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,17553735 0,19007329 ! neuron migration GO:0001764 79 42 0,000 0,17553735 0,18998779 ! regulation of protein secretion GO:0050708 71 42 0,000 0,17553735 0,18990236 ! regulation of myeloid cell differentiation GO:0045637 98 42 0,000 0,17553735 0,18981701 ! epithelial cell differentiation GO:0030855 79 43 0,000 0,17932042 0,19382072 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,17932042 0,19373369 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,17932042 0,19364673 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,17932042 0,19355986 ! striated muscle contraction GO:0006941 77 43 0,000 0,17932042 0,19347306 ! phagocytosis GO:0006909 90 43 0,000 0,17932042 0,19338634 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,17932042 0,1932997 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,18308625 0,19727072 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,18308625 0,19718242 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,18683494 0,20112969 ! glycolysis GO:0006096 65 45 0,000 0,18683494 0,20103974 ! regulation of JAK-STAT cascade GO:0046425 70 45 0,000 0,18683494 0,20094987 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,18683494 0,20086008 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,18683494 0,20077037 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,18683494 0,20068074 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,18683494 0,20059119 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,18683494 0,20050172 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,19056654 0,20441511 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,19056654 0,20432402 ! response to calcium ion GO:0051592 81 47 0,000 0,19428114 0,208214 ! endosome transport GO:0016197 108 47 0,000 0,19428114 0,20812129 ! positive regulation of DNA binding GO:0043388 73 47 0,000 0,19428114 0,20802867 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,19428114 0,20793613 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,19428114 0,20784368 ! JNK cascade GO:0007254 91 47 0,000 0,19428114 0,2077513 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,19428114 0,20765901 ! protein homooligomerization GO:0051260 76 47 0,000 0,19428114 0,2075668 ! Notch signaling pathway GO:0007219 96 48 0,000 0,19797882 0,21142345 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,19797882 0,21132965 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,19797882 0,21123594 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,20165965 0,21506787 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,20165965 0,21497258 ! regulation of ion transport GO:0043269 77 49 0,000 0,20165965 0,21487738 ! peptide metabolic process GO:0006518 76 49 0,000 0,20165965 0,21478226 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,20165965 0,21468722 ! endocrine system development GO:0035270 104 49 0,000 0,20165965 0,21459227 ! DNA-dependent DNA replication GO:0006261 74 49 0,000 0,20165965 0,2144974 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,20165965 0,21440262 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,20165965 0,21430792 ! neuromuscular process GO:0050905 99 50 0,000 0,20532371 0,21810545 ! inner ear development GO:0048839 79 50 0,000 0,20532371 0,2180092 ! histone modification GO:0016570 91 50 0,000 0,20532371 0,21791304 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,20532371 0,21781695 ! positive regulation of binding GO:0051099 78 51 0,000 0,20897108 0,22158855 ! viral infectious cycle GO:0019058 99 51 0,000 0,20897108 0,22149093 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,20897108 0,2213934 ! excretion GO:0007588 83 51 0,000 0,20897108 0,22129596 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,20897108 0,2211986 ! chromatin remodeling GO:0006338 109 51 0,000 0,20897108 0,22110132 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,20897108 0,22100414 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,20897108 0,22090703 ! membrane fusion GO:0006944 110 52 0,000 0,21260182 0,22464646 ! covalent chromatin modification GO:0016569 101 52 0,000 0,21260182 0,22454784 ! respiratory electron transport chain GO:0022904 76 53 0,000 0,21621602 0,22826492 ! RNA catabolic process GO:0006401 93 53 0,000 0,21621602 0,2281648 ! regulation of translational initiation GO:0006446 82 53 0,000 0,21621602 0,22806478 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,21621602 0,22796483 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,21621602 0,22786498 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,21621602 0,22776522 ! cell maturation GO:0048469 100 53 0,000 0,21621602 0,22766554 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,21621602 0,22756595 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,21981375 0,23125137 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,21981375 0,2311503 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,21981375 0,23104932 ! chloride transport GO:0006821 90 55 0,000 0,22339509 0,23471117 ! glucose catabolic process GO:0006007 82 55 0,000 0,22339509 0,23460872 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,22339509 0,23450636 ! regulation of protein catabolic process GO:0042176 116 55 0,000 0,22339509 0,23440409 ! RNA elongation GO:0006354 79 55 0,000 0,22339509 0,23430191 ! nuclear export GO:0051168 97 55 0,000 0,22339509 0,23419982 ! regulation of actin filament length GO:0030832 105 56 0,000 0,22696011 0,23783363 ! sensory perception of smell GO:0007608 80 56 0,000 0,22696011 0,23773009 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,22696011 0,23762664 ! proton transport GO:0015992 94 56 0,000 0,22696011 0,23752328 ! positive regulation of organelle organization GO:0010638 100 56 0,000 0,22696011 0,23742001 ! hydrogen transport GO:0006818 97 58 0,000 0,23404147 0,24472133 ! regulation of endocytosis GO:0030100 91 58 0,000 0,23404147 0,24461502 ! adult behavior GO:0030534 99 58 0,000 0,23404147 0,2445088 ! positive regulation of secretion GO:0051047 95 59 0,000 0,23755796 0,24807485 ! regulation of cellular component size GO:0032535 109 59 0,000 0,23755796 0,24796722 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,23755796 0,24785969 GO:0032313|regulation of Rab GTPase activity, ! cytokine-mediated signaling pathway GO:0019221 97 59 0,000 0,23755796 0,24775226 ! establishment of organelle localization GO:0051656 109 59 0,000 0,23755796 0,24764491 ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,24105843 0,25118518 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,24105843 0,25107644 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,24454294 0,25459555 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,24454294 0,25448543 ! tRNA processing GO:0008033 89 61 0,000 0,24454294 0,2543754 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,24454294 0,25426547 ! viral reproductive process GO:0022415 126 62 0,000 0,24801156 0,25776062 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,24801156 0,25764932 ! regulation of mitosis GO:0007088 105 63 0,000 0,25146438 0,26112357 GO:0051783|regulation of nuclear division, ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,25146438 0,26101092 ! regulation of lipid metabolic process GO:0019216 115 63 0,000 0,25146438 0,26089836 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,25146438 0,26078591 ! cell redox homeostasis GO:0045454 102 64 0,000 0,25490146 0,2642365 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,25490146 0,2641227 ! single fertilization GO:0007338 75 64 0,000 0,25490146 0,264009 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,25832287 0,26743753 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,25832287 0,2673225 ! myeloid cell differentiation GO:0030099 111 65 0,000 0,25832287 0,26720757 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 0,000 0,26172868 0,27061418 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,26172868 0,27049794 ! developmental maturation GO:0021700 116 66 0,000 0,26172868 0,2703818 ! cell projection assembly GO:0030031 120 66 0,000 0,26172868 0,27026575 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,26511896 0,27364917 ! activation of MAPK activity GO:0000187 115 67 0,000 0,26511896 0,27353183 ! chromosome segregation GO:0007059 113 67 0,000 0,26511896 0,27341458 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,26511896 0,27329744 ! hexose catabolic process GO:0019320 104 67 0,000 0,26511896 0,2731804 ! positive regulation of T cell activation GO:0050870 109 67 0,000 0,26511896 0,27306345 ! amino acid transport GO:0006865 125 68 0,000 0,26849379 0,27642108 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,26849379 0,27630285 ! negative regulation of ligase activity GO:0051352 112 68 0,000 0,26849379 0,27618472 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! viral reproduction GO:0016032 134 68 0,000 0,26849379 0,27606669 ! cAMP-mediated signaling GO:0019933 120 69 0,000 0,27185323 0,27940149 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,27185323 0,27928219 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,27185323 0,27916299 ! antigen processing and presentation GO:0019882 104 69 0,000 0,27185323 0,27904389 ! amine catabolic process GO:0009310 117 71 0,000 0,27852623 0,28577148 ! regulation of immune effector process GO:0002697 137 71 0,000 0,27852623 0,28564967 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,28513852 0,29230647 ! fertilization GO:0009566 90 73 0,000 0,28513852 0,29218198 ! transition metal ion transport GO:0000041 126 74 0,000 0,28842207 0,29542082 ! neurotransmitter transport GO:0006836 123 74 0,000 0,28842207 0,2952951 ! meiosis GO:0007126 121 74 0,000 0,28842207 0,2951695 GO:0051327|M phase of meiotic cell cycle, ! exocytosis GO:0006887 133 74 0,000 0,28842207 0,295044 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,28842207 0,29491861 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,28842207 0,29479333 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,29169064 0,29800751 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,29169064 0,29788102 ! meiotic cell cycle GO:0051321 122 75 0,000 0,29169064 0,29775464 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,29494431 0,30094826 ! defense response to bacterium GO:0042742 89 76 0,000 0,29494431 0,30082069 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,29494431 0,30069322 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,29494431 0,30056587 ! regulation of catabolic process GO:0009894 161 76 0,000 0,29494431 0,30043861 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,29818314 0,30360924 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,29818314 0,30348081 ! positive regulation of lymphocyte activation GO:0051251 127 77 0,000 0,29818314 0,30335249 ! blood coagulation GO:0007596 146 78 0,000 0,3014072 0,30650284 GO:0050817|coagulation, ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,3014072 0,30637335 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,30461655 0,30950482 ! regulation of adenylate cyclase activity GO:0045761 156 80 0,000 0,30781127 0,31261879 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,30781127 0,31248688 ! inorganic anion transport GO:0015698 138 80 0,000 0,30781127 0,31235509 ! regulation of cAMP biosynthetic process GO:0030817 161 82 0,000 0,31415706 0,31866015 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,31415706 0,31852587 ! regulation of cyclase activity GO:0031279 159 82 0,000 0,31415706 0,31839169 ! regulation of lyase activity GO:0051339 160 83 0,000 0,31730826 0,32144997 ! regulation of cAMP metabolic process GO:0030814 168 84 0,000 0,32044508 0,32449111 ! hemostasis GO:0007599 158 84 0,000 0,32044508 0,3243546 ! nucleosome assembly GO:0006334 122 85 0,000 0,3235676 0,32737748 ! positive regulation of cell activation GO:0050867 145 85 0,000 0,3235676 0,32723987 GO:0002696|positive regulation of leukocyte activation, ! oxidative phosphorylation GO:0006119 133 86 0,000 0,32667588 0,3302446 ! chromatin assembly GO:0031497 124 86 0,000 0,32667588 0,3301059 ! alcohol catabolic process GO:0046164 130 86 0,000 0,32667588 0,32996732 ! amine transport GO:0015837 155 86 0,000 0,32667588 0,32982885 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 0,000 0,32976997 0,33281315 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,32976997 0,3326736 ! cellular respiration GO:0045333 135 88 0,000 0,33284995 0,33563997 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,33284995 0,33549936 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 0,000 0,33896781 0,34152285 ! regulation of cell cycle process GO:0010564 149 90 0,000 0,33896781 0,34137989 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,33896781 0,34123705 ! sterol metabolic process GO:0016125 152 91 0,000 0,34200583 0,34415141 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,34200583 0,34400753 ! nucleosome organization GO:0034728 138 92 0,000 0,34502998 0,34690436 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,34502998 0,34675945 ! vitamin metabolic process GO:0006766 139 92 0,000 0,34502998 0,34661467 ! regulation of nucleotide metabolic process GO:0006140 182 93 0,000 0,34804033 0,34949292 ! carbohydrate biosynthetic process GO:0016051 141 93 0,000 0,34804033 0,34934712 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,35401989 0,35520094 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,35698922 0,35803088 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,359945 0,36084487 ! protein ubiquitination GO:0016567 217 97 0,000 0,359945 0,36069458 ! hormone metabolic process GO:0042445 157 97 0,000 0,359945 0,36054441 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,3628873 0,36334034 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,3628873 0,3631892 GO:0016054|organic acid catabolic process, ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 0,000 0,36581616 0,36596827 ! Golgi vesicle transport GO:0048193 207 99 0,000 0,36581616 0,36581616