pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6388-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! interphase of mitotic cell cycle GO:0051329 156 86 10,000 4,458E-12 1,025E-08 ! interphase GO:0051325 159 88 10,000 5,773E-12 6,639E-09 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 7,000 1,834E-10 1,406E-07 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 6,000 2,448E-08 1,408E-05 ! negative regulation of phosphorylation GO:0042326 41 23 4,000 2,41E-07 1,108E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 4,000 3,768E-07 1,444E-04 GO:0045936|negative regulation of phosphate metabolic process, ! cell cycle arrest GO:0007050 150 86 6,000 9,534E-07 3,133E-04 ! cell cycle checkpoint GO:0000075 108 64 5,000 2,566E-06 7,376E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 3,799E-06 9,71E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 4,000 3,814E-06 8,773E-04 ! positive regulation of protein ubiquitination GO:0031398 8 6 2,000 4,399E-06 9,199E-04 ! regulation of helicase activity GO:0051095 11 6 2,000 4,399E-06 8,432E-04 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 3,000 4,79E-06 8,474E-04 ! activation of caspase activity GO:0006919 65 43 4,000 6,254E-06 1,027E-03 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 3,000 7,327E-06 1,123E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 7,664E-06 1,102E-03 ! positive regulation of caspase activity GO:0043280 72 48 4,000 1,086E-05 1,469E-03 GO:0010952|positive regulation of peptidase activity, ! middle ear morphogenesis GO:0042474 9 8 2,000 1,221E-05 1,56E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 1,221E-05 1,478E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,221E-05 1,404E-03 ! negative regulation of cell development GO:0010721 56 24 3,000 1,283E-05 1,405E-03 GO:0050768|negative regulation of neurogenesis, ! insulin receptor signaling pathway GO:0008286 40 24 3,000 1,283E-05 1,341E-03 ! ear development GO:0043583 72 50 4,000 1,331E-05 1,331E-03 ! rRNA metabolic process GO:0016072 107 85 5,000 1,349E-05 1,293E-03 GO:0006364|rRNA processing, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 3,549E-05 3,265E-03 GO:0042130|negative regulation of T cell proliferation, ! mammary gland development GO:0030879 57 31 3,000 3,675E-05 3,251E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 3,834E-05 3,266E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 4,474E-05 3,675E-03 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 4,000 4,474E-05 3,548E-03 ! regulation of caspase activity GO:0043281 97 65 4,000 4,823E-05 3,698E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 5,34E-05 3,962E-03 ! regulation of endopeptidase activity GO:0052548 99 67 4,000 5,585E-05 4,014E-03 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 6,898E-05 4,808E-03 ! G1/S transition checkpoint GO:0031575 33 14 2,000 7,726E-05 5,226E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 7,726E-05 5,077E-03 ! regulation of peptidase activity GO:0052547 106 72 4,000 7,897E-05 5,046E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 7,897E-05 4,909E-03 GO:0045937|positive regulation of phosphate metabolic process, ! cell growth GO:0016049 61 39 3,000 9,251E-05 5,599E-03 ! negative regulation of growth GO:0045926 123 75 4,000 9,601E-05 5,662E-03 ! regulation of protein ubiquitination GO:0031396 19 15 2,000 9,614E-05 5,528E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 9,614E-05 5,393E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 9,614E-05 5,265E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 1,023E-04 5,472E-03 ! gland development GO:0048732 148 77 4,000 1,089E-04 5,69E-03 ! positive regulation of protein modification process GO:0031401 107 78 4,000 1,157E-04 5,916E-03 ! G1 phase GO:0051318 27 16 2,000 1,178E-04 5,89E-03 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 1,178E-04 5,765E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 1,362E-04 6,527E-03 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 1,701E-04 7,986E-03 ! cellular response to nutrient levels GO:0031669 27 18 2,000 1,701E-04 7,826E-03 ! negative regulation of T cell activation GO:0050868 25 18 2,000 1,701E-04 7,673E-03 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 1,739E-04 7,69E-03 ! response to UV GO:0009411 75 46 3,000 1,776E-04 7,707E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 2,011E-04 8,567E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 2,011E-04 8,411E-03 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 2,000 2,356E-04 9,675E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 2,736E-04 0,01104073 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 2,736E-04 0,01085038 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 2,736E-04 0,01066647 ! aging GO:0007568 79 52 3,000 2,865E-04 0,01098112 ! response to light stimulus GO:0009416 153 96 4,000 3,072E-04 0,01158257 ! skeletal system morphogenesis GO:0048705 78 53 3,000 3,084E-04 0,0114406 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 3,611E-04 0,01318357 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 3,611E-04 0,01297757 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 1,000 3,667E-04 0,01297541 ! regulation of interferon-beta production GO:0032648 5 5 1,000 3,667E-04 0,01277882 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 3,667E-04 0,01258809 ! endochondral ossification GO:0001958 12 5 1,000 3,667E-04 0,01240297 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 3,667E-04 0,01222321 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 3,667E-04 0,0120486 ! negative regulation of gliogenesis GO:0014014 16 5 1,000 3,667E-04 0,0118789 GO:0045686|negative regulation of glial cell differentiation, ! determination of adult lifespan GO:0008340 8 5 1,000 3,667E-04 0,01171391 ! DNA damage response, signal transduction GO:0042770 96 56 3,000 3,814E-04 0,01201738 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 4,083E-04 0,01269008 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 4,083E-04 0,01252088 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 4,109E-04 0,01243424 ! negative regulation of kinase activity GO:0033673 100 58 3,000 4,365E-04 0,0130378 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 4,648E-04 0,01370641 ! negative regulation of transferase activity GO:0051348 105 61 3,000 5,294E-04 0,01541245 ! prostate gland development GO:0030850 9 6 1,000 5,478E-04 0,01575054 ! activation of MAPKKK activity GO:0000185 10 6 1,000 5,478E-04 0,01555609 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 5,478E-04 0,01536638 ! hyperosmotic response GO:0006972 8 6 1,000 5,478E-04 0,01518125 ! ER overload response GO:0006983 7 6 1,000 5,478E-04 0,01500052 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 5,478E-04 0,01482404 ! cerebral cortex neuron differentiation GO:0021895 12 6 1,000 5,478E-04 0,01465167 ! negative regulation of DNA recombination GO:0045910 9 6 1,000 5,478E-04 0,01448326 ! response to exogenous dsRNA GO:0043330 8 6 1,000 5,478E-04 0,01431868 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 5,478E-04 0,01415779 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 5,478E-04 0,01400048 ! negative regulation of axon extension GO:0030517 13 6 1,000 5,478E-04 0,01384663 ! negative regulation of B cell activation GO:0050869 9 6 1,000 5,478E-04 0,01369613 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 5,859E-04 0,0144901 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 1,000 7,639E-04 0,01869159 GO:0016446|somatic hypermutation of immunoglobulin genes, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 7,639E-04 0,01849484 ! rRNA modification GO:0000154 12 7 1,000 7,639E-04 0,01830218 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 7,639E-04 0,0181135 ! multicellular organismal aging GO:0010259 11 7 1,000 7,639E-04 0,01792867 ! T cell lineage commitment GO:0002360 12 7 1,000 7,639E-04 0,01774757 ! response to tumor cell GO:0002347 12 7 1,000 7,639E-04 0,0175701 ! neuroblast proliferation GO:0007405 13 7 1,000 7,639E-04 0,01739613 ! negative regulation of osteoclast differentiation GO:0045671 10 7 1,000 7,639E-04 0,01722558 ! regulation of interferon-alpha production GO:0032647 7 7 1,000 7,639E-04 0,01705835 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 7,639E-04 0,01689432 ! RNA methylation GO:0001510 11 7 1,000 7,639E-04 0,01673342 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 1,000 7,639E-04 0,01657556 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 7,639E-04 0,01642065 ! B cell lineage commitment GO:0002326 17 7 1,000 7,639E-04 0,01626861 ! negative regulation of cell activation GO:0050866 44 30 2,000 8,025E-04 0,01693317 ! DNA damage checkpoint GO:0000077 53 31 2,000 8,845E-04 0,01849469 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 3,000 9,406E-04 0,01948968 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 9,717E-04 0,01995471 ! meiosis I GO:0007127 52 32 2,000 9,717E-04 0,01977812 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,014E-03 0,02046772 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,014E-03 0,02028974 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 1,014E-03 0,02011482 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 1,000 1,014E-03 0,0199429 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,014E-03 0,0197739 ! regulation of type I interferon production GO:0032479 8 8 1,000 1,014E-03 0,01960773 ! osteoblast development GO:0002076 13 8 1,000 1,014E-03 0,01944433 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,014E-03 0,01928363 GO:0045685|regulation of glial cell differentiation, ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,014E-03 0,01912557 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,014E-03 0,01897008 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,014E-03 0,01881709 ! mitochondrion organization GO:0007005 104 73 3,000 1,044E-03 0,01920677 ! negative regulation of cell adhesion GO:0007162 67 33 2,000 1,064E-03 0,01942485 ! ear morphogenesis GO:0042471 42 33 2,000 1,064E-03 0,0192719 ! nucleus organization GO:0006997 49 33 2,000 1,064E-03 0,01912134 ! negative regulation of DNA binding GO:0043392 54 33 2,000 1,064E-03 0,01897311 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 1,098E-03 0,01943233 ! regulation of ligase activity GO:0051340 114 75 3,000 1,155E-03 0,02027544 ! mitotic cell cycle checkpoint GO:0007093 63 34 2,000 1,162E-03 0,02024624 ! DNA integrity checkpoint GO:0031570 57 34 2,000 1,162E-03 0,02009401 ! regulation of DNA binding GO:0051101 119 77 3,000 1,274E-03 0,0218639 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 1,000 1,299E-03 0,02213335 ! lung alveolus development GO:0048286 17 9 1,000 1,299E-03 0,0219706 ! L-serine metabolic process GO:0006563 13 9 1,000 1,299E-03 0,02181023 ! motor axon guidance GO:0008045 14 9 1,000 1,299E-03 0,02165219 ! natural killer cell mediated immunity GO:0002228 13 9 1,000 1,299E-03 0,02149642 GO:0042267|natural killer cell mediated cytotoxicity, ! negative regulation of binding GO:0051100 58 36 2,000 1,374E-03 0,02257583 ! forebrain development GO:0030900 131 80 3,000 1,468E-03 0,02394606 ! regulation of T cell proliferation GO:0042129 58 38 2,000 1,609E-03 0,02606579 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,617E-03 0,02601464 ! hippocampus development GO:0021766 19 10 1,000 1,617E-03 0,02583398 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 1,617E-03 0,02565582 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 1,000 1,617E-03 0,02548009 ! regulation of chemokine biosynthetic process GO:0045073 12 10 1,000 1,617E-03 0,02530676 ! response to X-ray GO:0010165 16 10 1,000 1,617E-03 0,02513577 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,617E-03 0,02496707 ! negative regulation of axonogenesis GO:0050771 23 10 1,000 1,617E-03 0,02480062 ! response to dsRNA GO:0043331 18 10 1,000 1,617E-03 0,02463638 ! positive regulation of JNK cascade GO:0046330 14 10 1,000 1,617E-03 0,0244743 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 1,617E-03 0,02431434 ! regulation of cell adhesion GO:0030155 159 83 3,000 1,682E-03 0,02511977 ! inner ear development GO:0048839 57 40 2,000 1,868E-03 0,02772037 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 1,868E-03 0,02754267 ! JAK-STAT cascade GO:0007259 53 40 2,000 1,868E-03 0,02736724 ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,969E-03 0,02866228 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 1,000 1,969E-03 0,02848202 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 1,969E-03 0,028304 ! focal adhesion formation GO:0048041 24 11 1,000 1,969E-03 0,0281282 ! regulation of intracellular pH GO:0051453 17 11 1,000 1,969E-03 0,02795457 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 1,000 1,969E-03 0,02778307 ! regulation of osteoclast differentiation GO:0045670 15 11 1,000 1,969E-03 0,02761366 ! serine family amino acid biosynthetic process GO:0009070 13 11 1,000 1,969E-03 0,02744631 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 1,000 1,969E-03 0,02728097 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! leukocyte mediated cytotoxicity GO:0001909 17 11 1,000 1,969E-03 0,02711761 ! epithelial cell differentiation GO:0030855 55 41 2,000 2,007E-03 0,02747249 ! regulation of T cell differentiation GO:0045580 59 41 2,000 2,007E-03 0,02730993 ! regulation of JNK cascade GO:0046328 58 41 2,000 2,007E-03 0,02714928 ! cellular component disassembly GO:0022411 64 42 2,000 2,151E-03 0,02893828 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 2,000 2,151E-03 0,02877003 ! regulation of neurogenesis GO:0050767 153 89 3,000 2,173E-03 0,02889086 ! lactation GO:0007595 20 12 1,000 2,353E-03 0,03110745 ! negative regulation of cell projection organization GO:0031345 26 12 1,000 2,353E-03 0,03092969 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 1,000 2,353E-03 0,03075396 ! immunoglobulin production during immune response GO:0002381 20 12 1,000 2,353E-03 0,03058021 ! response to gamma radiation GO:0010332 20 12 1,000 2,353E-03 0,03040841 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 2,46E-03 0,03161173 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,624E-03 0,03353285 ! regulation of binding GO:0051098 151 95 3,000 2,755E-03 0,0350122 ! regulation of chemokine production GO:0032642 17 13 1,000 2,77E-03 0,03500728 ! endocrine pancreas development GO:0031018 19 13 1,000 2,77E-03 0,03481598 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 2,77E-03 0,03462677 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 2,77E-03 0,03443959 ! regulation of cellular pH GO:0030641 20 13 1,000 2,77E-03 0,03425444 ! regulation of axon extension GO:0030516 23 13 1,000 2,77E-03 0,03407126 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 1,000 2,77E-03 0,03389003 ! negative regulation of immune system process GO:0002683 73 47 2,000 2,972E-03 0,03617213 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 2,972E-03 0,03598175 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of DNA replication GO:0006275 75 48 2,000 3,157E-03 0,03801117 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 2,000 3,157E-03 0,03781319 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 3,157E-03 0,03761727 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 3,219E-03 0,03816287 ! neuron maturation GO:0042551 21 14 1,000 3,219E-03 0,03796716 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 3,219E-03 0,03777345 ! limbic system development GO:0021761 25 14 1,000 3,219E-03 0,03758171 ! activation of MAPKK activity GO:0000186 21 14 1,000 3,219E-03 0,0373919 ! cellular response to starvation GO:0009267 21 14 1,000 3,219E-03 0,03720401 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 3,219E-03 0,03701799 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 3,219E-03 0,03683382 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 1,000 3,219E-03 0,03665147 ! cell killing GO:0001906 20 14 1,000 3,219E-03 0,03647092 ! regulation of angiogenesis GO:0045765 94 49 2,000 3,348E-03 0,03774272 ! lipid phosphorylation GO:0046834 23 15 1,000 3,699E-03 0,04150533 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 3,699E-03 0,04130385 ! regulation of survival gene product expression GO:0045884 20 15 1,000 3,699E-03 0,04110431 ! response to osmotic stress GO:0006970 22 15 1,000 3,699E-03 0,04090669 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 3,699E-03 0,04071097 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 3,699E-03 0,04051711 ! cellular response to unfolded protein GO:0034620 19 16 1,000 4,211E-03 0,04590236 GO:0030968|endoplasmic reticulum unfolded protein response, ! detection of biotic stimulus GO:0009595 19 16 1,000 4,211E-03 0,04568584 ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 1,000 4,211E-03 0,04547136 ! DNA catabolic process GO:0006308 67 54 2,000 4,408E-03 0,04738029 ! detection of external stimulus GO:0009581 66 54 2,000 4,408E-03 0,04715992 ! cell-substrate junction assembly GO:0007044 39 17 1,000 4,754E-03 0,05061626 ! actin filament bundle formation GO:0051017 26 17 1,000 4,754E-03 0,05038301 ! neuromuscular junction development GO:0007528 23 17 1,000 4,754E-03 0,05015189 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 4,754E-03 0,04992289 ! cAMP metabolic process GO:0046058 33 18 1,000 5,326E-03 0,05568563 ! axis specification GO:0009798 26 18 1,000 5,326E-03 0,05543366 ! pancreas development GO:0031016 26 18 1,000 5,326E-03 0,05518396 ! response to retinoic acid GO:0032526 25 18 1,000 5,326E-03 0,0549365 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 5,326E-03 0,05469125 ! activation of JUN kinase activity GO:0007257 23 18 1,000 5,326E-03 0,05444817 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 5,326E-03 0,05420725 ! actin filament organization GO:0007015 95 59 2,000 5,652E-03 0,05726525 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 5,929E-03 0,05981443 ! response to alkaloid GO:0043279 32 19 1,000 5,929E-03 0,05955323 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 5,929E-03 0,0592943 ! response to vitamin A GO:0033189 26 19 1,000 5,929E-03 0,05903762 ! response to starvation GO:0042594 30 19 1,000 5,929E-03 0,05878315 ! plasma membrane fusion GO:0045026 23 19 1,000 5,929E-03 0,05853086 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 5,929E-03 0,05828073 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 5,929E-03 0,05803272 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 1,000 5,929E-03 0,05778682 ! somatic diversification of immunoglobulins GO:0016445 29 19 1,000 5,929E-03 0,05754299 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 5,929E-03 0,05730122 ! regulation of cellular response to stress GO:0080135 85 61 2,000 6,202E-03 0,05968573 ! meiosis GO:0007126 96 61 2,000 6,202E-03 0,05943704 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 6,202E-03 0,05919041 ! urogenital system development GO:0001655 101 61 2,000 6,202E-03 0,05894582 ! lymphocyte mediated immunity GO:0002449 88 62 2,000 6,489E-03 0,06141708 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 2,000 6,489E-03 0,06116537 ! meiotic cell cycle GO:0051321 97 62 2,000 6,489E-03 0,06091572 ! response to vitamin GO:0033273 29 20 1,000 6,562E-03 0,06135279 ! pallium development GO:0021543 38 20 1,000 6,562E-03 0,0611044 ! regulation of transcription factor activity GO:0051090 97 63 2,000 6,783E-03 0,06291018 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 6,783E-03 0,06265753 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 1,000 7,224E-03 0,06646102 GO:0016444|somatic cell DNA recombination, ! gluconeogenesis GO:0006094 25 21 1,000 7,224E-03 0,06619624 ! regulation of DNA recombination GO:0000018 40 21 1,000 7,224E-03 0,06593355 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 7,224E-03 0,06567295 ! cell aging GO:0007569 32 21 1,000 7,224E-03 0,06541439 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 7,224E-03 0,06515786 ! immunoglobulin production GO:0002377 33 21 1,000 7,224E-03 0,06490334 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 1,000 7,224E-03 0,0646508 ! B cell activation GO:0042113 104 65 2,000 7,396E-03 0,0659329 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 2,000 7,396E-03 0,06567833 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 2,000 7,396E-03 0,06542572 ! regulation of MAPKKK cascade GO:0043408 101 65 2,000 7,396E-03 0,06517505 ! cell-substrate adhesion GO:0031589 121 66 2,000 7,714E-03 0,06771946 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 7,915E-03 0,06921763 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 7,915E-03 0,06895544 ! regulation of cell-matrix adhesion GO:0001952 51 22 1,000 7,915E-03 0,06869523 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 7,915E-03 0,06843698 ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 7,915E-03 0,06818066 ! protein tetramerization GO:0051262 39 22 1,000 7,915E-03 0,06792625 ! regulation of neuron differentiation GO:0045664 107 67 2,000 8,04E-03 0,06874599 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 8,634E-03 0,07355138 ! myelination GO:0042552 35 23 1,000 8,634E-03 0,07327997 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 8,634E-03 0,07301056 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 8,634E-03 0,07274312 ! negative regulation of DNA replication GO:0008156 35 23 1,000 8,634E-03 0,07247763 ! osteoblast differentiation GO:0001649 40 23 1,000 8,634E-03 0,07221408 ! somatic diversification of immune receptors GO:0002200 35 23 1,000 8,634E-03 0,07195243 ! activation of protein kinase activity GO:0032147 102 69 2,000 8,717E-03 0,07237729 ! response to drug GO:0042493 108 69 2,000 8,717E-03 0,07211694 ! positive regulation of ligase activity GO:0051351 99 69 2,000 8,717E-03 0,07185845 ! regulation of interferon-gamma production GO:0032649 30 24 1,000 9,382E-03 0,07706541 ! pyruvate metabolic process GO:0006090 29 24 1,000 9,382E-03 0,07679115 ! fat cell differentiation GO:0045444 37 24 1,000 9,382E-03 0,07651884 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 1,000 9,382E-03 0,07624846 ! mitochondrial membrane organization GO:0007006 39 24 1,000 9,382E-03 0,07597998 ! base-excision repair GO:0006284 31 24 1,000 9,382E-03 0,07571338 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 9,382E-03 0,07544865 ! leukocyte mediated immunity GO:0002443 99 71 2,000 9,426E-03 0,07553648 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01015727 0,0811171 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,01015727 0,08083641 ! positive regulation of MAPKKK cascade GO:0043410 36 25 1,000 0,01015727 0,08055767 ! protein import into nucleus GO:0006606 118 74 2,000 0,01055048 0,08338868 ! response to nutrient GO:0007584 104 75 2,000 0,01094197 0,08618672 ! nuclear import GO:0051170 121 75 2,000 0,01094197 0,08589257 ! regulation of pH GO:0006885 36 26 1,000 0,01096012 0,08574241 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01096012 0,08545176 ! negative regulation of protein modification process GO:0031400 50 26 1,000 0,01096012 0,08516307 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01096012 0,08487633 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 1,000 0,01179005 0,09099706 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! response to ionizing radiation GO:0010212 47 27 1,000 0,01179005 0,09069272 ! serine family amino acid metabolic process GO:0009069 37 27 1,000 0,01179005 0,09039041 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01179005 0,09009011 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01179005 0,0897918 ! cell junction assembly GO:0034329 56 28 1,000 0,01264673 0,09599826 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,01264673 0,09568247 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 1,000 0,01264673 0,09536876 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01264673 0,0950571 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 1,000 0,01264673 0,09474747 ! protein localization in nucleus GO:0034504 133 80 2,000 0,01302481 0,09726316 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,01352978 0,10070713 ! mismatch repair GO:0006298 34 29 1,000 0,01352978 0,10038227 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01352978 0,1000595 ! telencephalon development GO:0021537 52 29 1,000 0,01352978 0,0997388 ! hexose biosynthetic process GO:0019319 35 29 1,000 0,01352978 0,09942014 ! tissue homeostasis GO:0001894 42 29 1,000 0,01352978 0,09910352 GO:0048871|multicellular organismal homeostasis, ! detection of stimulus GO:0051606 108 82 2,000 0,01391696 0,10161587 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,01443888 0,10509309 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,01443888 0,10476157 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01443888 0,10443213 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 0,01531897 0,11045025 ! transcription initiation GO:0006352 118 85 2,000 0,01531897 0,1101051 ! glial cell differentiation GO:0010001 55 31 1,000 0,01537366 0,11015395 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,01537366 0,10981186 ! metanephros development GO:0001656 58 31 1,000 0,01537366 0,10947188 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,01537366 0,10913401 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01537366 0,10879821 ! RNA modification GO:0009451 40 31 1,000 0,01537366 0,10846447 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,01633379 0,11488598 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01633379 0,11453572 ! regulation of protein stability GO:0031647 48 32 1,000 0,01633379 0,11418759 ! cytokine production GO:0001816 44 32 1,000 0,01633379 0,11384157 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,01633379 0,11349763 ! regulation of T cell activation GO:0050863 128 89 2,000 0,01730813 0,11990569 ! cell junction organization GO:0034330 63 33 1,000 0,01731893 0,11962023 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01731893 0,11926208 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01731893 0,11890608 ! mRNA catabolic process GO:0006402 48 34 1,000 0,01832874 0,12546458 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,01832874 0,12509228 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,01832874 0,12472219 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 1,000 0,01832874 0,12435428 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,01832874 0,12398853 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,01832874 0,12362493 ! DNA recombination GO:0006310 146 92 2,000 0,01889032 0,12704016 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,01936289 0,12983861 ! cyclic nucleotide metabolic process GO:0009187 58 35 1,000 0,01936289 0,12946118 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,01936289 0,12908593 ! maintenance of protein location GO:0045185 65 35 1,000 0,01936289 0,12871285 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,02042105 0,13535565 GO:0090047|positive regulation of transcription regulator activity, ! in utero embryonic development GO:0001701 147 96 2,000 0,02112081 0,13959158 ! gliogenesis GO:0042063 71 38 1,000 0,02260809 0,14899315 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02260809 0,14856745 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,02260809 0,14814418 ! pigmentation GO:0043473 74 38 1,000 0,02260809 0,14772332 ! maintenance of location in cell GO:0051651 69 38 1,000 0,02260809 0,14730484 ! protein import GO:0017038 156 99 2,000 0,02288453 0,14868483 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,02288453 0,148266 ! protein localization in organelle GO:0033365 161 100 2,000 0,02348976 0,15175967 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,02373633 0,15292313 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,02373633 0,15249597 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 1,000 0,02373633 0,15207119 ! JNK cascade GO:0007254 54 39 1,000 0,02373633 0,15164877 ! synapse organization GO:0050808 55 39 1,000 0,02373633 0,15122869 ! response to calcium ion GO:0051592 58 40 1,000 0,02488729 0,15812365 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,02488729 0,15768805 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,02488729 0,15725484 ! T cell differentiation GO:0030217 65 40 1,000 0,02488729 0,15682401 ! double-strand break repair GO:0006302 67 40 1,000 0,02488729 0,15639553 ! B cell differentiation GO:0030183 62 40 1,000 0,02488729 0,15596938 ! glucose transport GO:0015758 52 41 1,000 0,02606065 0,16287908 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,02606065 0,16243767 ! biopolymer methylation GO:0043414 62 41 1,000 0,02606065 0,16199865 ! mitochondrial transport GO:0006839 60 42 1,000 0,02725611 0,16897319 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,02725611 0,16851896 ! hexose transport GO:0008645 54 42 1,000 0,02725611 0,16806717 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 1,000 0,02725611 0,16761779 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 1,000 0,02725611 0,16717081 ! positive regulation of binding GO:0051099 59 43 1,000 0,02847335 0,1741721 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,02847335 0,17371011 ! methylation GO:0032259 64 43 1,000 0,02847335 0,17325056 ! activation of adenylate cyclase activity GO:0007190 76 44 1,000 0,02971207 0,18031073 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,02971207 0,17983623 ! regulation of action potential GO:0001508 71 44 1,000 0,02971207 0,17936422 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,02971207 0,17889468 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,02971207 0,17842759 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,02971207 0,17796294 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03023399 0,18061866 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03023399 0,18015074 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03023399 0,17968523 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03023399 0,17922213 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03023399 0,1787614 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03023399 0,17830304 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03023399 0,17784702 ! sleep GO:0030431 11 5 0,000 0,03023399 0,17739333 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03023399 0,17694195 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03023399 0,17649285 ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03023399 0,17604604 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03023399 0,17560148 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03023399 0,17515916 ! tongue development GO:0043586 6 5 0,000 0,03023399 0,17471906 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03023399 0,17428116 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03023399 0,17384546 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03023399 0,17341193 ! cobalt ion transport GO:0006824 9 5 0,000 0,03023399 0,17298056 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03023399 0,17255133 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03023399 0,17212422 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03023399 0,17169922 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03023399 0,17127632 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03023399 0,17085549 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03023399 0,17043673 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03023399 0,17002001 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03023399 0,16960533 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03023399 0,16919266 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03023399 0,168782 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03023399 0,16837333 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03023399 0,16796663 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03023399 0,16756189 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03023399 0,1671591 ! malate metabolic process GO:0006108 7 5 0,000 0,03023399 0,16675824 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03023399 0,16635929 ! behavioral response to pain GO:0048266 7 5 0,000 0,03023399 0,16596225 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03023399 0,16556711 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03023399 0,16517384 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03023399 0,16478243 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03023399 0,16439287 ! mating behavior GO:0007617 6 5 0,000 0,03023399 0,16400515 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03023399 0,16361926 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03023399 0,16323518 ! rhythmic behavior GO:0007622 12 5 0,000 0,03023399 0,16285289 ! copulation GO:0007620 7 5 0,000 0,03023399 0,16247239 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03023399 0,16209367 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03023399 0,16171671 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03023399 0,1613415 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03023399 0,16096802 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03023399 0,16059627 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03023399 0,16022623 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03023399 0,1598579 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03023399 0,15949125 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03023399 0,15912628 ! response to protozoan GO:0001562 9 5 0,000 0,03023399 0,15876298 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03023399 0,15840133 ! lymph vessel development GO:0001945 7 5 0,000 0,03023399 0,15804133 ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03023399 0,15768296 ! parathyroid gland development GO:0060017 8 5 0,000 0,03023399 0,15732621 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03023399 0,15697107 ! anagen GO:0042640 6 5 0,000 0,03023399 0,15661753 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03023399 0,15626558 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03023399 0,15591521 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03023399 0,15556641 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03023399 0,15521916 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03023399 0,15487346 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03023399 0,1545293 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03023399 0,15418666 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03023399 0,15384554 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03023399 0,15350593 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03023399 0,15316781 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03023399 0,15283117 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03023399 0,15249602 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03023399 0,15216233 ! ovulation GO:0030728 6 5 0,000 0,03023399 0,1518301 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03023399 0,15149931 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03023399 0,15116997 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,03023399 0,15084205 ! response to pH GO:0009268 9 5 0,000 0,03023399 0,15051555 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03023399 0,15019046 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03023399 0,14986678 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03023399 0,14954448 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03023399 0,14922357 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03023399 0,14890404 ! polyol catabolic process GO:0046174 7 5 0,000 0,03023399 0,14858586 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03023399 0,14826905 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03023399 0,14795358 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03023399 0,14763946 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03023399 0,14732666 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03023399 0,14701519 ! urea metabolic process GO:0019627 6 5 0,000 0,03023399 0,14670503 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03023399 0,14639618 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03023399 0,14608862 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03023399 0,14578236 ! neutrophil activation GO:0042119 5 5 0,000 0,03023399 0,14547737 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03023399 0,14517366 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03023399 0,14487122 ! response to food GO:0032094 5 5 0,000 0,03023399 0,14457003 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03023399 0,14427009 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03023399 0,1439714 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03023399 0,14367394 ! forebrain neuron development GO:0021884 7 5 0,000 0,03023399 0,1433777 ! melanosome organization GO:0032438 7 5 0,000 0,03023399 0,14308268 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03023399 0,14278888 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03023399 0,14249628 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03023399 0,14220488 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03023399 0,14191466 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03023399 0,14162563 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03023399 0,14133777 ! nucleoside transport GO:0015858 6 5 0,000 0,03023399 0,14105108 ! nucleoside salvage GO:0043174 7 5 0,000 0,03023399 0,14076556 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03023399 0,14048118 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03023399 0,14019795 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03023399 0,13991586 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03023399 0,13963491 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03023399 0,13935508 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03023399 0,13907637 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03023399 0,13879877 ! depyrimidination GO:0045008 8 5 0,000 0,03023399 0,13852228 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03023399 0,13824689 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03023399 0,13797259 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03023399 0,13769938 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03023399 0,13742724 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03023399 0,13715618 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03023399 0,13688619 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03023399 0,13661726 ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03023399 0,13634938 ! monocyte differentiation GO:0030224 8 5 0,000 0,03023399 0,13608255 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03023399 0,13581677 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03023399 0,13555202 ! centrosome duplication GO:0051298 5 5 0,000 0,03023399 0,1352883 ! response to UV-C GO:0010225 6 5 0,000 0,03023399 0,1350256 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03023399 0,13476392 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03023399 0,13450326 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03023399 0,1342436 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03023399 0,13398494 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03023399 0,13372728 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03023399 0,1334706 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03023399 0,13321491 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03023399 0,1329602 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03023399 0,13270646 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03023399 0,13245368 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03023399 0,13220187 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03023399 0,13195101 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03023399 0,13170111 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03023399 0,13145214 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03023399 0,13120412 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03023399 0,13095703 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03023399 0,13071087 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03023399 0,13046564 ! neural tube patterning GO:0021532 6 5 0,000 0,03023399 0,13022132 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03023399 0,12997792 ! histone demethylation GO:0016577 9 5 0,000 0,03023399 0,12973542 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03023399 0,12949383 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03023399 0,12925313 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03023399 0,12901333 ! enteric nervous system development GO:0048484 8 5 0,000 0,03023399 0,12877442 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03023399 0,12853639 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03023399 0,12829923 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03023399 0,12806295 ! transcription termination GO:0006353 8 5 0,000 0,03023399 0,12782755 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03023399 0,127593 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03023399 0,12735931 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03023399 0,12712648 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03023399 0,1268945 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03023399 0,12666336 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03023399 0,12643306 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03023399 0,1262036 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03023399 0,12597497 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03023399 0,12574717 ! apical protein localization GO:0045176 6 5 0,000 0,03023399 0,12552019 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03023399 0,12529403 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03023399 0,12506868 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03023399 0,12484414 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03023399 0,1246204 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03023399 0,12439747 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03023399 0,12417533 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03023399 0,12395398 ! glial cell migration GO:0008347 10 5 0,000 0,03023399 0,12373342 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03023399 0,12351365 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03023399 0,12329465 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03023399 0,12307643 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03023399 0,12285898 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03023399 0,1226423 ! neural plate development GO:0001840 6 5 0,000 0,03023399 0,12242638 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03023399 0,12221122 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03023399 0,12199682 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03023399 0,12178316 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03023399 0,12157025 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03023399 0,12135809 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03023399 0,12114666 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03023399 0,12093597 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03023399 0,12072601 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03023399 0,12051678 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03023399 0,12030828 ! spindle assembly GO:0051225 5 5 0,000 0,03023399 0,12010049 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03023399 0,11989342 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03023399 0,11968706 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03023399 0,11948142 ! organ regeneration GO:0031100 7 5 0,000 0,03023399 0,11927647 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03023399 0,11907223 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03023399 0,11886869 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03023399 0,11866584 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03023399 0,11846369 GO:0055081|anion homeostasis, ! RNA catabolic process GO:0006401 64 45 1,000 0,03097197 0,12114886 ! cell maturation GO:0048469 60 45 1,000 0,03097197 0,12094317 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,03097197 0,12073818 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 1,000 0,03225274 0,12551828 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,03225274 0,12530625 ! endocrine system development GO:0035270 83 47 1,000 0,03355409 0,13014233 ! positive regulation of cyclase activity GO:0031281 87 47 1,000 0,03355409 0,12992324 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,03355409 0,12970488 ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,03487572 0,13458751 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 1,000 0,03487572 0,13436207 ! tRNA transcription GO:0009304 11 6 0,000 0,03617122 0,13912009 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03617122 0,13888783 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03617122 0,13865635 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03617122 0,13842565 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03617122 0,1381957 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03617122 0,13796652 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03617122 0,1377381 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03617122 0,13751043 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03617122 0,13728352 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03617122 0,13705735 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03617122 0,13683193 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03617122 0,13660725 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03617122 0,1363833 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,03617122 0,13616009 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03617122 0,1359376 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03617122 0,13571584 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03617122 0,13549481 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03617122 0,13527449 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03617122 0,13505489 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,03617122 0,134836 ! neuron adhesion GO:0007158 9 6 0,000 0,03617122 0,13461782 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,03617122 0,13440034 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03617122 0,13418357 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03617122 0,13396749 ! signal peptide processing GO:0006465 8 6 0,000 0,03617122 0,13375211 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03617122 0,13353742 ! mRNA stabilization GO:0048255 15 6 0,000 0,03617122 0,13332342 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03617122 0,1331101 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03617122 0,13289746 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03617122 0,13268551 ! opsonization GO:0008228 8 6 0,000 0,03617122 0,13247422 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03617122 0,13226361 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03617122 0,13205367 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03617122 0,13184439 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03617122 0,13163578 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03617122 0,13142782 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03617122 0,13122052 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03617122 0,13101388 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03617122 0,13080788 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03617122 0,13060253 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03617122 0,13039783 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03617122 0,13019376 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03617122 0,12999033 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03617122 0,12978754 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03617122 0,12958538 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03617122 0,12938385 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03617122 0,12918294 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,03617122 0,12898266 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03617122 0,12878299 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03617122 0,12858395 ! thymic T cell selection GO:0045061 12 6 0,000 0,03617122 0,12838551 ! protein lipoylation GO:0009249 10 6 0,000 0,03617122 0,12818769 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03617122 0,12799048 ! pigment granule organization GO:0048753 11 6 0,000 0,03617122 0,12779388 ! drug transport GO:0015893 6 6 0,000 0,03617122 0,12759787 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03617122 0,12740247 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03617122 0,12720766 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03617122 0,12701345 ! histidine metabolic process GO:0006547 6 6 0,000 0,03617122 0,12681984 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03617122 0,12662681 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03617122 0,12643437 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03617122 0,12624251 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03617122 0,12605123 ! adenohypophysis development GO:0021984 10 6 0,000 0,03617122 0,12586053 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03617122 0,12567041 ! microtubule nucleation GO:0007020 10 6 0,000 0,03617122 0,12548086 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03617122 0,12529189 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03617122 0,12510348 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03617122 0,12491563 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03617122 0,12472835 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03617122 0,12454164 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,03617122 0,12435548 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03617122 0,12416987 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03617122 0,12398482 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03617122 0,12380032 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03617122 0,12361636 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03617122 0,12343296 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03617122 0,12325009 ! neuron apoptosis GO:0051402 8 6 0,000 0,03617122 0,12306777 ! organic alcohol transport GO:0015850 9 6 0,000 0,03617122 0,12288599 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,03617122 0,12270474 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03617122 0,12252402 ! male sex determination GO:0030238 9 6 0,000 0,03617122 0,12234384 ! carnitine transport GO:0015879 8 6 0,000 0,03617122 0,12216419 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03617122 0,12198506 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03617122 0,12180646 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03617122 0,12162838 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03617122 0,12145082 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03617122 0,12127378 ! parturition GO:0007567 12 6 0,000 0,03617122 0,12109725 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03617122 0,12092124 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03617122 0,12074574 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03617122 0,12057074 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03617122 0,12039626 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03617122 0,12022227 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03617122 0,12004879 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03617122 0,11987581 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03617122 0,11970333 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03617122 0,11953134 ! macrophage differentiation GO:0030225 10 6 0,000 0,03617122 0,11935985 ! astrocyte development GO:0014002 14 6 0,000 0,03617122 0,11918884 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03617122 0,11901833 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03617122 0,1188483 ! interaction with symbiont GO:0051702 8 6 0,000 0,03617122 0,11867876 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03617122 0,1185097 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03617122 0,11834113 ! eating behavior GO:0042755 6 6 0,000 0,03617122 0,11817303 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03617122 0,11800541 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03617122 0,11783826 ! response to copper ion GO:0046688 9 6 0,000 0,03617122 0,11767159 ! DNA topological change GO:0006265 8 6 0,000 0,03617122 0,11750539 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03617122 0,11733965 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03617122 0,11717438 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03617122 0,11700958 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03617122 0,11684524 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03617122 0,11668136 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03617122 0,11651795 ! gas homeostasis GO:0033483 11 6 0,000 0,03617122 0,11635498 ! hair follicle maturation GO:0048820 7 6 0,000 0,03617122 0,11619248 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03617122 0,11603042 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03617122 0,11586882 ! Schwann cell development GO:0014044 14 6 0,000 0,03617122 0,11570767 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03617122 0,11554696 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03617122 0,1153867 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03617122 0,11522689 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03617122 0,11506751 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,03617122 0,11490858 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03617122 0,11475009 ! histone ubiquitination GO:0016574 7 6 0,000 0,03617122 0,11459203 ! regulation of meiosis GO:0040020 10 6 0,000 0,03617122 0,11443441 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03617122 0,11427722 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03617122 0,11412046 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03617122 0,11396413 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03617122 0,11380823 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03617122 0,11365275 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03617122 0,1134977 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03617122 0,11334307 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03617122 0,11318886 ! receptor internalization GO:0031623 9 6 0,000 0,03617122 0,11303507 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03617122 0,1128817 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03617122 0,11272874 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03617122 0,1125762 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03617122 0,11242407 ! protein deubiquitination GO:0016579 8 6 0,000 0,03617122 0,11227235 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03617122 0,11212104 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03617122 0,11197014 ! axonal fasciculation GO:0007413 9 6 0,000 0,03617122 0,11181964 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03617122 0,11166955 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03617122 0,11151986 ! midbrain development GO:0030901 6 6 0,000 0,03617122 0,11137057 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03617122 0,11122167 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03617122 0,11107318 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03617122 0,11092508 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03617122 0,11077738 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03617122 0,11063007 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03617122 0,11048315 GO:0046479|glycosphingolipid catabolic process, ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03617122 0,11033662 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03617122 0,11019048 ! adult feeding behavior GO:0008343 6 6 0,000 0,03617122 0,11004473 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03617122 0,10989936 ! blastocyst growth GO:0001832 15 6 0,000 0,03617122 0,10975437 ! pigment granule transport GO:0051904 12 6 0,000 0,03617122 0,10960977 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03617122 0,10946554 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03617122 0,1093217 ! catecholamine transport GO:0051937 7 6 0,000 0,03617122 0,10917823 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03617122 0,10903514 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03617122 0,10889243 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03617122 0,10875008 ! protein prenylation GO:0018342 10 6 0,000 0,03617122 0,10860811 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03617122 0,10846651 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,03617122 0,10832528 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03617122 0,10818441 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03617122 0,10804391 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03617122 0,10790378 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,03621734 0,1079014 ! maintenance of location GO:0051235 84 49 1,000 0,03621734 0,10776181 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,03757866 0,11166786 ! membrane fusion GO:0006944 80 50 1,000 0,03757866 0,11152377 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,03757866 0,11138006 ! lipid modification GO:0030258 73 50 1,000 0,03757866 0,11123671 ! muscle fiber development GO:0048747 74 51 1,000 0,0389594 0,11517561 ! positive regulation of cell migration GO:0030335 92 51 1,000 0,0389594 0,11502776 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,0389594 0,11488029 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,04035927 0,11885572 ! kidney development GO:0001822 90 53 1,000 0,04177799 0,12287644 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04207244 0,12358444 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04207244 0,1234268 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04207244 0,12326957 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04207244 0,12311274 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04207244 0,12295631 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04207244 0,12280027 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04207244 0,12264463 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04207244 0,12248938 ! reproductive behavior GO:0019098 12 7 0,000 0,04207244 0,12233453 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04207244 0,12218007 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04207244 0,12202599 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,04207244 0,12187231 ! oligopeptide transport GO:0006857 11 7 0,000 0,04207244 0,12171901 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04207244 0,1215661 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04207244 0,12141357 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04207244 0,12126142 ! pericardium development GO:0060039 8 7 0,000 0,04207244 0,12110965 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04207244 0,12095827 ! fibril organization GO:0043206 13 7 0,000 0,04207244 0,12080726 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04207244 0,12065663 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04207244 0,12050637 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04207244 0,12035648 ! lipoprotein transport GO:0042953 9 7 0,000 0,04207244 0,12020697 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04207244 0,12005783 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04207244 0,11990906 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04207244 0,11976066 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04207244 0,11961262 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04207244 0,11946495 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04207244 0,11931765 ! chemosensory behavior GO:0007635 9 7 0,000 0,04207244 0,11917071 ! microtubule bundle formation GO:0001578 8 7 0,000 0,04207244 0,11902412 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,04207244 0,1188779 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04207244 0,11873204 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04207244 0,11858654 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04207244 0,11844139 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04207244 0,11829659 ! reflex GO:0060004 12 7 0,000 0,04207244 0,11815215 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04207244 0,11800807 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04207244 0,11786433 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04207244 0,11772094 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04207244 0,1175779 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04207244 0,11743521 ! spinal cord patterning GO:0021511 7 7 0,000 0,04207244 0,11729286 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04207244 0,11715086 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04207244 0,11700921 ! adrenal gland development GO:0030325 17 7 0,000 0,04207244 0,11686789 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04207244 0,11672692 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04207244 0,11658628 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04207244 0,11644598 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04207244 0,11630603 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04207244 0,1161664 ! endosome organization GO:0007032 10 7 0,000 0,04207244 0,11602711 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04207244 0,11588816 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04207244 0,11574954 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04207244 0,11561125 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04207244 0,11547329 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04207244 0,11533565 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04207244 0,11519835 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04207244 0,11506137 ! galactose metabolic process GO:0006012 10 7 0,000 0,04207244 0,11492472 ! vesicle fusion GO:0006906 15 7 0,000 0,04207244 0,11478839 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04207244 0,11465239 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04207244 0,1145167 ! organ growth GO:0035265 11 7 0,000 0,04207244 0,11438134 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04207244 0,1142463 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04207244 0,11411157 ! retinol metabolic process GO:0042572 9 7 0,000 0,04207244 0,11397717 ! behavioral fear response GO:0001662 13 7 0,000 0,04207244 0,11384307 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04207244 0,1137093 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04207244 0,11357584 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04207244 0,11344269 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04207244 0,11330985 ! response to UV-B GO:0010224 11 7 0,000 0,04207244 0,11317733 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04207244 0,11304511 ! intermediate filament organization GO:0045109 11 7 0,000 0,04207244 0,1129132 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04207244 0,1127816 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04207244 0,11265031 ! fibrinolysis GO:0042730 9 7 0,000 0,04207244 0,11251932 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,04207244 0,11238863 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04207244 0,11225825 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04207244 0,11212817 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04207244 0,1119984 ! response to tropane GO:0014073 13 7 0,000 0,04207244 0,11186892 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04207244 0,11173974 ! melanosome localization GO:0032400 10 7 0,000 0,04207244 0,11161086 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04207244 0,11148227 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04207244 0,11135399 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04207244 0,11122599 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04207244 0,11109829 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04207244 0,11097089 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04207244 0,11084377 ! mast cell activation GO:0045576 9 7 0,000 0,04207244 0,11071695 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04207244 0,11059042 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04207244 0,11046417 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04207244 0,11033821 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04207244 0,11021254 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04207244 0,11008716 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,04207244 0,10996206 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04207244 0,10983725 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04207244 0,10971271 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04207244 0,10958846 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04207244 0,10946449 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04207244 0,10934081 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04207244 0,1092174 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04207244 0,10909427 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04207244 0,10897141 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04207244 0,10884883 ! diuresis GO:0030146 12 7 0,000 0,04207244 0,10872653 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04207244 0,1086045 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04207244 0,10848275 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04207244 0,10836127 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04207244 0,10824006 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04207244 0,10811912 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04207244 0,10799845 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04207244 0,10787805 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04207244 0,10775792 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04207244 0,10763806 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04207244 0,10751846 ! lymph node development GO:0048535 9 7 0,000 0,04207244 0,10739913 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04207244 0,10728006 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04207244 0,10716126 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04207244 0,10704271 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04207244 0,10692443 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04207244 0,10680642 ! ATP catabolic process GO:0006200 10 7 0,000 0,04207244 0,10668866 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04207244 0,10657116 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04207244 0,10645392 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04207244 0,10633694 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04207244 0,10622021 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04207244 0,10610374 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04207244 0,10598753 ! muscle adaptation GO:0043500 12 7 0,000 0,04207244 0,10587157 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04207244 0,10575586 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04207244 0,10564041 ! retina homeostasis GO:0001895 9 7 0,000 0,04207244 0,10552521 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04207244 0,10541025 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04207244 0,10529555 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04207244 0,1051811 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04207244 0,1050669 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04207244 0,10495294 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04207244 0,10483923 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04207244 0,10472577 ! mesoderm development GO:0007498 76 55 1,000 0,04467087 0,11107351 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,04614448 0,11461371 ! positive regulation of cell motion GO:0051272 99 56 1,000 0,04614448 0,11449007 ! carbohydrate transport GO:0008643 74 57 1,000 0,04763584 0,11806296 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,04763584 0,11793588 GO:0048609|reproductive process in a multicellular organism, ! developmental maturation GO:0021700 75 57 1,000 0,04763584 0,11780906 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04793786 0,11842866 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04793786 0,11830159 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,04793786 0,1181748 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04793786 0,11804827 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04793786 0,11792201 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04793786 0,11779603 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04793786 0,11767031 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04793786 0,11754487 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,04793786 0,11741968 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,04793786 0,11729477 ! phosphate transport GO:0006817 10 8 0,000 0,04793786 0,11717012 ! N-glycan processing GO:0006491 12 8 0,000 0,04793786 0,11704574 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04793786 0,11692162 ! UTP metabolic process GO:0046051 8 8 0,000 0,04793786 0,11679776 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04793786 0,11667416 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04793786 0,11655083 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,04793786 0,11642775 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04793786 0,11630494 ! succinate metabolic process GO:0006105 14 8 0,000 0,04793786 0,11618239 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,04793786 0,11606009 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,04793786 0,11593805 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04793786 0,11581626 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04793786 0,11569474 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04793786 0,11557346 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04793786 0,11545244 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04793786 0,11533168 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04793786 0,11521116 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04793786 0,1150909 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04793786 0,11497089 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04793786 0,11485113 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04793786 0,11473162 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,04793786 0,11461235 ! astrocyte differentiation GO:0048708 16 8 0,000 0,04793786 0,11449334 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04793786 0,11437457 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04793786 0,11425605 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04793786 0,11413777 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04793786 0,11401974 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04793786 0,11390195 ! melanin metabolic process GO:0006582 12 8 0,000 0,04793786 0,1137844 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04793786 0,1136671 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04793786 0,11355003 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,04793786 0,11343321 ! macrophage activation GO:0042116 12 8 0,000 0,04793786 0,11331663 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04793786 0,11320029 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04793786 0,11308419 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04793786 0,11296832 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,04793786 0,1128527 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04793786 0,1127373 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04793786 0,11262215 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04793786 0,11250723 ! ruffle organization GO:0031529 11 8 0,000 0,04793786 0,11239254 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04793786 0,11227809 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04793786 0,11216387 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04793786 0,11204988 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04793786 0,11193613 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04793786 0,1118226 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04793786 0,1117093 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,04793786 0,11159624 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04793786 0,1114834 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04793786 0,11137079 ! brain morphogenesis GO:0048854 20 8 0,000 0,04793786 0,11125841 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04793786 0,11114625 ! segment specification GO:0007379 10 8 0,000 0,04793786 0,11103432 ! cellular extravasation GO:0045123 11 8 0,000 0,04793786 0,11092262 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04793786 0,11081114 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04793786 0,11069988 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04793786 0,11058885 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04793786 0,11047804 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04793786 0,11036745 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04793786 0,11025708 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04793786 0,11014694 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,04793786 0,11003701 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04793786 0,1099273 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04793786 0,10981781 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04793786 0,10970854 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04793786 0,10959949 ! icosanoid secretion GO:0032309 12 8 0,000 0,04793786 0,10949065 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04793786 0,10938203 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04793786 0,10927362 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04793786 0,10916543 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04793786 0,10905745 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04793786 0,10894969 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04793786 0,10884214 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04793786 0,1087348 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04793786 0,10862767 ! sterol catabolic process GO:0016127 9 8 0,000 0,04793786 0,10852075 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04793786 0,10841405 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04793786 0,10830755 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04793786 0,10820126 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04793786 0,10809518 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04793786 0,10798931 ! prophase GO:0051324 11 8 0,000 0,04793786 0,10788364 ! S phase GO:0051320 8 8 0,000 0,04793786 0,10777819 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04793786 0,10767293 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04793786 0,10756789 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04793786 0,10746304 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04793786 0,10735841 ! hormone catabolic process GO:0042447 13 8 0,000 0,04793786 0,10725397 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04793786 0,10714974 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04793786 0,10704571 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04793786 0,10694189 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04793786 0,10683826 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04793786 0,10673483 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04793786 0,10663161 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04793786 0,10652858 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04793786 0,10642576 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04793786 0,10632313 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04793786 0,1062207 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04793786 0,10611846 ! regulation of embryonic development GO:0045995 16 8 0,000 0,04793786 0,10601643 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,04793786 0,10591459 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,04793786 0,10581294 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,04793786 0,10571149 ! regulation of cytokine biosynthetic process GO:0042035 76 58 1,000 0,04914468 0,10826894 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,04914468 0,10816533 ! activation of MAPK activity GO:0000187 84 59 1,000 0,05067075 0,11141752 ! lung development GO:0030324 94 59 1,000 0,05067075 0,1113111 ! nucleoside monophosphate metabolic process GO:0009123 95 59 1,000 0,05067075 0,11120489 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,05067075 0,11109888 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,05221377 0,11437302 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,05221377 0,1142642 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,05221377 0,11415558 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,0537677 0,11744133 ! regulation of developmental growth GO:0048638 13 9 0,000 0,0537677 0,1173299 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,0537677 0,11721869 ! telencephalon cell migration GO:0022029 16 9 0,000 0,0537677 0,11710769 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,0537677 0,1169969 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,0537677 0,11688631 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,0537677 0,11677594 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,0537677 0,11666577 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,0537677 0,11655581 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,0537677 0,11644606 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,0537677 0,11633652 ! GTP metabolic process GO:0046039 9 9 0,000 0,0537677 0,11622718 ! elastic fiber assembly GO:0048251 13 9 0,000 0,0537677 0,11611805 ! social behavior GO:0035176 14 9 0,000 0,0537677 0,11600912 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,0537677 0,11590039 ! artery development GO:0060840 19 9 0,000 0,0537677 0,11579187 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,0537677 0,11568355 ! regulation of glycolysis GO:0006110 15 9 0,000 0,0537677 0,11557544 ! response to pain GO:0048265 16 9 0,000 0,0537677 0,11546752 ! protein complex disassembly GO:0043241 17 9 0,000 0,0537677 0,11535981 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,0537677 0,1152523 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,0537677 0,11514499 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,0537677 0,11503788 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,0537677 0,11493097 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,0537677 0,11482425 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,0537677 0,11471774 ! ventral spinal cord development GO:0021517 11 9 0,000 0,0537677 0,11461142 ! protein targeting to ER GO:0045047 19 9 0,000 0,0537677 0,1145053 ! T cell selection GO:0045058 18 9 0,000 0,0537677 0,11439937 ! endoderm development GO:0007492 12 9 0,000 0,0537677 0,11429364 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,0537677 0,11418811 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,0537677 0,11408277 ! arginine catabolic process GO:0006527 10 9 0,000 0,0537677 0,11397762 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,0537677 0,11387267 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,0537677 0,11376791 GO:0010833|telomere maintenance via telomere lengthening, ! phosphagen metabolic process GO:0006599 12 9 0,000 0,0537677 0,11366334 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,0537677 0,11355897 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,0537677 0,11345479 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,0537677 0,1133508 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,0537677 0,113247 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,0537677 0,11314338 ! mannose metabolic process GO:0006013 9 9 0,000 0,0537677 0,11303996 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,0537677 0,11293673 ! receptor clustering GO:0043113 15 9 0,000 0,0537677 0,11283369 ! epithelial cell development GO:0002064 10 9 0,000 0,0537677 0,11273083 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,0537677 0,11262816 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,0537677 0,11252568 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,0537677 0,11242338 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,0537677 0,11232127 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,0537677 0,11221935 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,0537677 0,11211761 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,0537677 0,11201605 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,0537677 0,11191468 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,0537677 0,11181349 ! blastoderm segmentation GO:0007350 11 9 0,000 0,0537677 0,11171248 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,0537677 0,11161166 ! DNA ligation GO:0006266 14 9 0,000 0,0537677 0,11151102 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,0537677 0,11141056 ! response to amine stimulus GO:0014075 13 9 0,000 0,0537677 0,11131028 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,0537677 0,11121018 ! erythrocyte development GO:0048821 11 9 0,000 0,0537677 0,11111026 ! renal water homeostasis GO:0003091 14 9 0,000 0,0537677 0,11101052 ! postreplication repair GO:0006301 11 9 0,000 0,0537677 0,11091096 ! mRNA cleavage GO:0006379 13 9 0,000 0,0537677 0,11081158 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,0537677 0,11071237 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,0537677 0,11061334 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,0537677 0,11051449 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,0537677 0,11041582 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,0537677 0,11031732 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,0537677 0,110219 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,0537677 0,11012085 ! acid secretion GO:0046717 14 9 0,000 0,0537677 0,11002288 ! musculoskeletal movement GO:0050881 11 9 0,000 0,0537677 0,10992508 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,0537677 0,10982746 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,0537677 0,10973001 ! purine base metabolic process GO:0006144 18 9 0,000 0,0537677 0,10963273 ! oocyte differentiation GO:0009994 12 9 0,000 0,0537677 0,10953562 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,0537677 0,10943869 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,0537677 0,10934193 ! spleen development GO:0048536 15 9 0,000 0,0537677 0,10924533 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,0537677 0,10914891 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,0537677 0,10905266 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,0537677 0,10895658 ! detection of calcium ion GO:0005513 13 9 0,000 0,0537677 0,10886067 ! blastocyst formation GO:0001825 12 9 0,000 0,0537677 0,10876492 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,0537677 0,10866935 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,0537677 0,10857394 ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,0537677 0,1084787 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,0537677 0,10838363 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,0537677 0,10828872 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,0537677 0,10819398 ! prepulse inhibition GO:0060134 14 9 0,000 0,0537677 0,1080994 ! embryonic placenta development GO:0001892 12 9 0,000 0,0537677 0,10800499 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,0537677 0,10791075 ! insulin secretion GO:0030073 17 9 0,000 0,0537677 0,10781667 ! sequestering of metal ion GO:0051238 11 9 0,000 0,0537677 0,10772275 ! response to nicotine GO:0035094 16 9 0,000 0,0537677 0,107629 ! establishment of cell polarity GO:0030010 12 9 0,000 0,0537677 0,10753541 ! nucleus localization GO:0051647 15 9 0,000 0,0537677 0,10744198 ! regulation of synapse organization GO:0050807 12 9 0,000 0,0537677 0,10734871 ! localization within membrane GO:0051668 15 9 0,000 0,0537677 0,10725561 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,05377349 0,10717419 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,05377349 0,1070814 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,05377349 0,10698877 ! respiratory tube development GO:0030323 99 62 1,000 0,05534964 0,11002954 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,05694198 0,1130972 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,05694198 0,11299961 ! respiratory system development GO:0060541 100 64 1,000 0,05855025 0,116091 ! adaptive immune response GO:0002250 94 64 1,000 0,05855025 0,11599101 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! negative regulation of muscle development GO:0048635 12 10 0,000 0,05956218 0,11789416 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05956218 0,11779279 ! neuron fate specification GO:0048665 11 10 0,000 0,05956218 0,11769159 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05956218 0,11759057 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05956218 0,11748972 ! thyroid gland development GO:0030878 19 10 0,000 0,05956218 0,11738904 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,05956218 0,11728854 ! synapsis GO:0007129 13 10 0,000 0,05956218 0,1171882 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05956218 0,11708804 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05956218 0,11698805 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05956218 0,11688823 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,05956218 0,11678859 ! sulfate transport GO:0008272 12 10 0,000 0,05956218 0,11668911 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05956218 0,1165898 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,05956218 0,11649066 ! androgen metabolic process GO:0008209 13 10 0,000 0,05956218 0,11639168 ! phospholipid efflux GO:0033700 16 10 0,000 0,05956218 0,11629288 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,05956218 0,11619424 ! blood vessel remodeling GO:0001974 21 10 0,000 0,05956218 0,11609577 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,05956218 0,11599747 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05956218 0,11589933 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,05956218 0,11580136 ! pathogenesis GO:0009405 13 10 0,000 0,05956218 0,11570356 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05956218 0,11560592 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,05956218 0,11550844 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05956218 0,11541113 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,05956218 0,11531398 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05956218 0,115217 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05956218 0,11512018 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05956218 0,11502352 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05956218 0,11492702 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05956218 0,11483069 ! B cell proliferation GO:0042100 14 10 0,000 0,05956218 0,11473451 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05956218 0,1146385 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05956218 0,11454265 ! forebrain cell migration GO:0021885 17 10 0,000 0,05956218 0,11444696 ! lipid digestion GO:0044241 15 10 0,000 0,05956218 0,11435143 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05956218 0,11425606 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05956218 0,11416084 ! UV protection GO:0009650 14 10 0,000 0,05956218 0,11406579 ! entry into host cell GO:0030260 20 10 0,000 0,05956218 0,11397089 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,05956218 0,11387615 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05956218 0,11378157 ! negative regulation of ossification GO:0030279 19 10 0,000 0,05956218 0,11368715 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,05956218 0,11359288 ! regulation of bone resorption GO:0045124 24 10 0,000 0,05956218 0,11349877 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,05956218 0,11340481 ! regulation of organ growth GO:0046620 11 10 0,000 0,05956218 0,11331101 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05956218 0,11321736 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05956218 0,11312387 ! embryonic axis specification GO:0000578 12 10 0,000 0,05956218 0,11303054 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05956218 0,11293735 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05956218 0,11284433 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,05956218 0,11275145 ! cranial nerve development GO:0021545 12 10 0,000 0,05956218 0,11265873 ! fucose catabolic process GO:0019317 16 10 0,000 0,05956218 0,11256616 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,05956218 0,11247374 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,05956218 0,11238147 ! protein sumoylation GO:0016925 12 10 0,000 0,05956218 0,11228935 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05956218 0,11219739 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05956218 0,11210557 ! zymogen activation GO:0031638 14 10 0,000 0,05956218 0,11201391 ! salivary gland development GO:0007431 22 10 0,000 0,05956218 0,11192239 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05956218 0,11183103 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05956218 0,11173981 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,05956218 0,11164875 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05956218 0,11155783 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,05956218 0,11146706 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05956218 0,11137643 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05956218 0,11128596 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05956218 0,11119563 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05956218 0,11110544 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,05956218 0,11101541 GO:0043470|regulation of carbohydrate catabolic process, ! detection of bacterium GO:0016045 10 10 0,000 0,05956218 0,11092551 ! embryonic gut development GO:0048566 11 10 0,000 0,05956218 0,11083577 ! activation of innate immune response GO:0002218 10 10 0,000 0,05956218 0,11074617 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05956218 0,11065671 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05956218 0,1105674 ! developmental induction GO:0031128 13 10 0,000 0,05956218 0,11047823 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05956218 0,11038921 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05956218 0,11030033 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05956218 0,11021159 ! reproductive structure development GO:0048608 90 65 1,000 0,06017419 0,11125453 ! defense response to bacterium GO:0042742 73 65 1,000 0,06017419 0,11116517 ! protein oligomerization GO:0051259 100 65 1,000 0,06017419 0,11107596 ! axon guidance GO:0007411 99 66 1,000 0,06181357 0,11401059 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,06513764 0,12004532 ! rRNA transcription GO:0009303 17 11 0,000 0,0653215 0,12028779 ! respiratory burst GO:0045730 14 11 0,000 0,0653215 0,12019156 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,0653215 0,12009548 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,0653215 0,11999956 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,0653215 0,11990379 ! virus-host interaction GO:0019048 17 11 0,000 0,0653215 0,11980817 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,0653215 0,11971271 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,0653215 0,11961739 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,0653215 0,11952223 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,0653215 0,11942722 ! RNA polyadenylation GO:0043631 19 11 0,000 0,0653215 0,11933237 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,0653215 0,11923766 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,0653215 0,1191431 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,0653215 0,11904869 ! T cell proliferation GO:0042098 20 11 0,000 0,0653215 0,11895443 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,0653215 0,11886032 ! bone resorption GO:0045453 16 11 0,000 0,0653215 0,11876636 ! regulated secretory pathway GO:0045055 14 11 0,000 0,0653215 0,11867255 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,0653215 0,11857889 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,0653215 0,11848537 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,0653215 0,118392 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,0653215 0,11829878 ! syncytium formation GO:0006949 15 11 0,000 0,0653215 0,1182057 ! plasma membrane organization GO:0007009 18 11 0,000 0,0653215 0,11811277 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,0653215 0,11801999 ! mitotic spindle organization GO:0007052 15 11 0,000 0,0653215 0,11792735 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,0653215 0,11783486 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,0653215 0,11774251 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,0653215 0,11765031 ! adult heart development GO:0007512 11 11 0,000 0,0653215 0,11755825 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,0653215 0,11746634 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,0653215 0,11737457 ! temperature homeostasis GO:0001659 16 11 0,000 0,0653215 0,11728294 ! L-glutamate transport GO:0015813 16 11 0,000 0,0653215 0,11719146 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,0653215 0,11710012 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,0653215 0,11700892 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,0653215 0,11691786 ! stem cell development GO:0048864 29 11 0,000 0,0653215 0,11682694 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,0653215 0,11673617 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,0653215 0,11664553 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,0653215 0,11655504 ! vasoconstriction GO:0042310 15 11 0,000 0,0653215 0,11646469 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,0653215 0,11637448 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,0653215 0,1162844 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,0653215 0,11619447 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,0653215 0,11610467 ! ribosome assembly GO:0042255 13 11 0,000 0,0653215 0,11601502 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,0653215 0,1159255 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,0653215 0,11583612 ! chromatin silencing GO:0006342 19 11 0,000 0,0653215 0,11574688 ! nucleosome positioning GO:0016584 13 11 0,000 0,0653215 0,11565777 ! T cell homeostasis GO:0043029 20 11 0,000 0,0653215 0,11556881 ! regulation of isotype switching GO:0045191 19 11 0,000 0,0653215 0,11547998 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,0653215 0,11539128 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,0653215 0,11530272 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,0653215 0,1152143 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,0653215 0,11512601 ! oxygen transport GO:0015671 15 11 0,000 0,0653215 0,11503786 ! male genitalia development GO:0030539 13 11 0,000 0,0653215 0,11494985 ! cholesterol efflux GO:0033344 19 11 0,000 0,0653215 0,11486196 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,0653215 0,11477422 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,0653215 0,1146866 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,0653215 0,11459912 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,0653215 0,11451177 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,0653215 0,11442456 ! defense response to fungus GO:0050832 12 11 0,000 0,0653215 0,11433748 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,0653215 0,11425053 ! lysogeny GO:0030069 18 11 0,000 0,0653215 0,11416371 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,0653215 0,11407703 ! acrosome reaction GO:0007340 13 11 0,000 0,0653215 0,11399048 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,0653215 0,11390405 ! response to metal ion GO:0010038 103 70 1,000 0,06852051 0,1193918 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,06852051 0,11930142 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,0702334 0,12219125 ! muscle cell differentiation GO:0042692 104 71 1,000 0,0702334 0,12209889 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,0702334 0,12200667 ! reproductive cellular process GO:0048610 14 12 0,000 0,07104588 0,12332492 ! tRNA modification GO:0006400 14 12 0,000 0,07104588 0,12323191 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,07104588 0,12313905 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,07104588 0,12304632 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,07104588 0,12295374 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,07104588 0,12286129 ! non-recombinational repair GO:0000726 19 12 0,000 0,07104588 0,12276898 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,07104588 0,12267681 ! peroxisomal transport GO:0043574 21 12 0,000 0,07104588 0,12258478 ! cartilage condensation GO:0001502 18 12 0,000 0,07104588 0,12249289 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,07104588 0,12240114 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,07104588 0,12230952 ! heart looping GO:0001947 15 12 0,000 0,07104588 0,12221804 ! palate development GO:0060021 15 12 0,000 0,07104588 0,12212669 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,07104588 0,12203549 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,07104588 0,12194441 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,07104588 0,12185348 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,07104588 0,12176268 ! arginine metabolic process GO:0006525 13 12 0,000 0,07104588 0,12167201 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,07104588 0,12158149 ! methionine metabolic process GO:0006555 13 12 0,000 0,07104588 0,12149109 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,07104588 0,12140083 ! Golgi organization GO:0007030 18 12 0,000 0,07104588 0,1213107 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,07104588 0,12122071 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,07104588 0,12113085 ! monoamine transport GO:0015844 13 12 0,000 0,07104588 0,12104112 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07104588 0,12095153 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,07104588 0,12086207 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,07104588 0,12077274 ! L-amino acid transport GO:0015807 20 12 0,000 0,07104588 0,12068354 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,07104588 0,12059448 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,07104588 0,12050554 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,07104588 0,12041674 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,07104588 0,12032807 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,07104588 0,12023953 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,07104588 0,12015111 ! cerebellum development GO:0021549 13 12 0,000 0,07104588 0,12006283 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,07104588 0,11997468 ! histone acetylation GO:0016573 23 12 0,000 0,07104588 0,11988666 ! histone methylation GO:0016571 15 12 0,000 0,07104588 0,11979877 ! autonomic nervous system development GO:0048483 23 12 0,000 0,07104588 0,119711 ! gland morphogenesis GO:0022612 23 12 0,000 0,07104588 0,11962336 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,07104588 0,11953586 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,07104588 0,11944848 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,07104588 0,11936122 ! regulation of epidermis development GO:0045682 17 12 0,000 0,07104588 0,1192741 ! intestinal absorption GO:0050892 19 12 0,000 0,07104588 0,1191871 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,07104588 0,11910023 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,07104588 0,11901349 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,07104588 0,11892687 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,07104588 0,11884038 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,07104588 0,11875401 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,07104588 0,11866777 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,07104588 0,11858165 ! microspike assembly GO:0030035 23 12 0,000 0,07104588 0,11849566 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,07104588 0,11840979 ! response to cold GO:0009409 14 12 0,000 0,07104588 0,11832405 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,07196029 0,11976025 ! negative regulation of transport GO:0051051 116 73 1,000 0,07370094 0,12256845 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,07673552 0,1275229 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,07673552 0,12743083 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07673552 0,12733889 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07673552 0,12724708 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,07673552 0,1271554 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,07673552 0,12706386 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07673552 0,12697245 ! lipid localization GO:0010876 24 13 0,000 0,07673552 0,12688116 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07673552 0,12679001 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,07673552 0,12669899 ! organelle fusion GO:0048284 28 13 0,000 0,07673552 0,12660811 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07673552 0,12651735 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,07673552 0,12642672 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07673552 0,12633622 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07673552 0,12624585 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,07673552 0,12615561 ! glutamate metabolic process GO:0006536 18 13 0,000 0,07673552 0,1260655 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07673552 0,12597552 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07673552 0,12588566 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,07673552 0,12579594 ! NAD metabolic process GO:0019674 21 13 0,000 0,07673552 0,12570634 ! exocrine system development GO:0035272 27 13 0,000 0,07673552 0,12561687 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,07673552 0,12552752 ! bone mineralization GO:0030282 15 13 0,000 0,07673552 0,12543831 ! regulation of exocytosis GO:0017157 17 13 0,000 0,07673552 0,12534922 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,07673552 0,12526025 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,07673552 0,12517142 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07673552 0,12508271 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,07673552 0,12499412 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,07673552 0,12490566 ! genitalia development GO:0048806 15 13 0,000 0,07673552 0,12481733 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,07673552 0,12472912 ! cellular pigmentation GO:0033059 24 13 0,000 0,07673552 0,12464103 ! tissue regeneration GO:0042246 21 13 0,000 0,07673552 0,12455307 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,07673552 0,12446523 ! cofactor transport GO:0051181 19 13 0,000 0,07673552 0,12437752 ! NADP metabolic process GO:0006739 18 13 0,000 0,07673552 0,12428993 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07673552 0,12420246 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,07673552 0,12411512 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07673552 0,1240279 ! gas transport GO:0015669 18 13 0,000 0,07673552 0,1239408 ! regulation of RNA stability GO:0043487 28 13 0,000 0,07673552 0,12385382 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07673552 0,12376697 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,07673552 0,12368024 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07673552 0,12359363 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07673552 0,12350714 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07673552 0,12342077 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,07673552 0,12333452 ! response to inorganic substance GO:0010035 115 75 1,000 0,0772226 0,12403072 ! amine biosynthetic process GO:0009309 97 76 1,000 0,07900317 0,12680201 ! response to unfolded protein GO:0006986 99 76 1,000 0,07900317 0,12671359 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,07900317 0,12662528 ! regulation of protein transport GO:0051223 114 76 1,000 0,07900317 0,1265371 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,08079659 0,12931952 ! sex differentiation GO:0007548 105 77 1,000 0,08079659 0,12922959 ! protein ubiquitination GO:0016567 125 77 1,000 0,08079659 0,12913978 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,08079659 0,1290501 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,08079659 0,12896055 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,08239064 0,13141364 ! superoxide anion generation GO:0042554 18 14 0,000 0,08239064 0,13132258 ! regulation of S phase GO:0033261 18 14 0,000 0,08239064 0,13123163 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,08239064 0,13114081 ! myotube differentiation GO:0014902 21 14 0,000 0,08239064 0,13105012 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,08239064 0,13095955 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,08239064 0,13086911 ! inositol metabolic process GO:0006020 20 14 0,000 0,08239064 0,1307788 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,08239064 0,1306886 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,08239064 0,13059854 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,08239064 0,13050859 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,08239064 0,13041877 ! gene silencing by RNA GO:0031047 20 14 0,000 0,08239064 0,13032908 ! response to cAMP GO:0051591 19 14 0,000 0,08239064 0,1302395 ! startle response GO:0001964 21 14 0,000 0,08239064 0,13015005 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,08239064 0,13006072 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,08239064 0,12997152 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,08239064 0,12988244 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,08239064 0,12979348 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,08239064 0,12970464 ! glycine metabolic process GO:0006544 22 14 0,000 0,08239064 0,12961592 ! pituitary gland development GO:0021983 23 14 0,000 0,08239064 0,12952732 ! lysosomal transport GO:0007041 20 14 0,000 0,08239064 0,12943885 ! regulation of heart rate GO:0002027 23 14 0,000 0,08239064 0,1293505 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,08239064 0,12926226 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,08239064 0,12917415 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,08239064 0,12908616 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,08239064 0,12899828 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,08239064 0,12891053 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,08239064 0,12882289 ! axon cargo transport GO:0008088 27 14 0,000 0,08239064 0,12873538 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,08239064 0,12864798 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,08239064 0,1285607 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,08239064 0,12847354 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,08239064 0,1283865 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,08239064 0,12829958 ! mRNA splice site selection GO:0006376 26 14 0,000 0,08239064 0,12821277 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,08239064 0,12812608 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,08239064 0,12803951 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,08239064 0,12795306 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,08239064 0,12786672 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,08239064 0,1277805 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,08239064 0,12769439 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,08239064 0,1276084 ! muscle maintenance GO:0046716 19 14 0,000 0,08239064 0,12752253 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,08239064 0,12743677 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,08239064 0,12735113 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,08239064 0,1272656 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,08239064 0,12718019 ! cilium assembly GO:0042384 20 14 0,000 0,08239064 0,12709489 ! peptide hormone secretion GO:0030072 23 14 0,000 0,08239064 0,1270097 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,08260264 0,12725122 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,08442111 0,12996557 ! T cell activation GO:0042110 134 79 1,000 0,08442111 0,12987864 ! regulation of lyase activity GO:0051339 133 79 1,000 0,08442111 0,12979182 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,08625179 0,13251778 GO:0010498|proteasomal protein catabolic process, ! positive regulation of cell size GO:0045793 20 15 0,000 0,08801145 0,13513106 ! metencephalon development GO:0022037 19 15 0,000 0,08801145 0,13504091 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,08801145 0,13495088 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,08801145 0,13486098 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,08801145 0,13477119 ! skin development GO:0043588 25 15 0,000 0,08801145 0,13468152 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,08801145 0,13459197 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,08801145 0,13450254 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,08801145 0,13441323 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,08801145 0,13432404 ! bile acid metabolic process GO:0008206 22 15 0,000 0,08801145 0,13423496 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,08801145 0,13414601 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,08801145 0,13405717 ! adult walking behavior GO:0007628 25 15 0,000 0,08801145 0,13396845 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,08801145 0,13387984 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,08801145 0,13379136 ! myoblast differentiation GO:0045445 27 15 0,000 0,08801145 0,13370299 ! centrosome cycle GO:0007098 16 15 0,000 0,08801145 0,13361474 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,08801145 0,1335266 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,08801145 0,13343858 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,08801145 0,13335067 ! cerebral cortex development GO:0021987 29 15 0,000 0,08801145 0,13326289 ! vesicle coating GO:0006901 25 15 0,000 0,08801145 0,13317521 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,08801145 0,13308766 ! DNA integration GO:0015074 22 15 0,000 0,08801145 0,13300021 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,08801145 0,13291289 ! peptide secretion GO:0002790 27 15 0,000 0,08801145 0,13282567 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,08801145 0,13273857 ! regulation of vasodilation GO:0042312 24 15 0,000 0,08801145 0,13265159 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,08801145 0,13256472 ! neuron recognition GO:0008038 22 15 0,000 0,08801145 0,13247796 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,08801145 0,13239132 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,08801145 0,13230479 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,08801145 0,13221837 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,08801145 0,13213207 ! biomineral formation GO:0031214 18 15 0,000 0,08801145 0,13204587 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,08801145 0,13195979 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,08801145 0,13187383 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,08801145 0,13178797 ! dopamine metabolic process GO:0042417 30 15 0,000 0,08801145 0,13170223 ! organic cation transport GO:0015695 19 15 0,000 0,08801145 0,1316166 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,08801145 0,13153108 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,08801145 0,13144567 ! defense response to virus GO:0051607 27 15 0,000 0,08801145 0,13136037 ! peptide hormone processing GO:0016486 19 15 0,000 0,08801145 0,13127518 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,08809445 0,13131383 ! mRNA transport GO:0051028 121 81 1,000 0,08809445 0,13122878 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,08809445 0,13114384 ! response to protein stimulus GO:0051789 111 81 1,000 0,08809445 0,13105901 ! ossification GO:0001503 134 82 1,000 0,08994889 0,13373138 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,09181489 0,13641747 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein secretion GO:0009306 27 16 0,000 0,09359814 0,13897722 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,09359814 0,13888756 ! hormone secretion GO:0046879 25 16 0,000 0,09359814 0,13879801 ! bone remodeling GO:0046849 24 16 0,000 0,09359814 0,13870858 ! endothelial cell migration GO:0043542 22 16 0,000 0,09359814 0,13861927 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,09359814 0,13853006 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,09359814 0,13844098 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,09359814 0,138352 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,09359814 0,13826315 ! glial cell development GO:0021782 24 16 0,000 0,09359814 0,1381744 ! patterning of blood vessels GO:0001569 24 16 0,000 0,09359814 0,13808577 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,09359814 0,13799726 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,09359814 0,13790885 ! protein polyubiquitination GO:0000209 26 16 0,000 0,09359814 0,13782056 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,09359814 0,13773239 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,09359814 0,13764432 ! fructose metabolic process GO:0006000 20 16 0,000 0,09359814 0,13755637 ! regulation of protein binding GO:0043393 27 16 0,000 0,09359814 0,13746853 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,09359814 0,1373808 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,09359814 0,13729319 ! protein export from nucleus GO:0006611 24 16 0,000 0,09359814 0,13720568 ! negative regulation of immune response GO:0050777 28 16 0,000 0,09359814 0,13711829 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,09359814 0,13703101 ! DNA replication initiation GO:0006270 25 16 0,000 0,09359814 0,13694384 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,09359814 0,13685678 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,09359814 0,13676983 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,09359814 0,136683 ! diencephalon development GO:0021536 25 16 0,000 0,09359814 0,13659627 ! oogenesis GO:0048477 23 16 0,000 0,09359814 0,13650965 ! neural crest cell migration GO:0001755 24 16 0,000 0,09359814 0,13642314 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,09359814 0,13633674 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,09359814 0,13625046 GO:0006626|protein targeting to mitochondrion, ! steroid catabolic process GO:0006706 22 16 0,000 0,09359814 0,13616428 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,09359814 0,1360782 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,09359814 0,13599224 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,09359814 0,13590639 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,09359814 0,13582064 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,09359814 0,13573501 ! sperm-egg recognition GO:0035036 16 16 0,000 0,09359814 0,13564948 GO:0007339|binding of sperm to zona pellucida, ! nerve development GO:0021675 18 16 0,000 0,09359814 0,13556406 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,09359814 0,13547874 ! negative regulation of translation GO:0017148 22 16 0,000 0,09359814 0,13539353 ! regulation of protein localization GO:0032880 132 85 1,000 0,09558076 0,13817458 ! regulation of membrane potential GO:0042391 128 85 1,000 0,09558076 0,13808779 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,09748023 0,14074358 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,09915093 0,14306596 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,09915093 0,14297626 ! negative regulation of defense response GO:0031348 19 17 0,000 0,09915093 0,14288667 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,09915093 0,1427972 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,09915093 0,14270784 ! glycerol metabolic process GO:0006071 20 17 0,000 0,09915093 0,14261859 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,09915093 0,14252946 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,09915093 0,14244043 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,09915093 0,14235152 ! signal complex assembly GO:0007172 29 17 0,000 0,09915093 0,14226272 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,09915093 0,14217402 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,09915093 0,14208544 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,09915093 0,14199697 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,09915093 0,14190861 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,09915093 0,14182036 ! memory GO:0007613 25 17 0,000 0,09915093 0,14173221 ! keratinization GO:0031424 17 17 0,000 0,09915093 0,14164418 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,09915093 0,14155626 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,09915093 0,14146844 ! retinoid metabolic process GO:0001523 22 17 0,000 0,09915093 0,14138074 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,09915093 0,14129314 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,09915093 0,14120565 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,09915093 0,14111828 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,09915093 0,141031 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,09915093 0,14094384 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,09915093 0,14085678 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,09915093 0,14076983 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,09915093 0,14068299 ! membrane budding GO:0006900 29 17 0,000 0,09915093 0,14059626 ! heme metabolic process GO:0042168 27 17 0,000 0,09915093 0,14050963 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,09915093 0,14042311 ! body fluid secretion GO:0007589 27 17 0,000 0,09915093 0,1403367 ! stem cell differentiation GO:0048863 36 17 0,000 0,09915093 0,14025039 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,09915093 0,14016419 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,09915093 0,14007809 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,09915093 0,1399921 ! sensory perception of pain GO:0019233 23 17 0,000 0,09915093 0,13990622 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,09915093 0,13982044 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,09915093 0,13973476 ! synaptogenesis GO:0007416 24 17 0,000 0,09915093 0,13964919 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,09915093 0,13956373 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,09915093 0,13947837 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,09915093 0,13939311 ! cell-cell junction organization GO:0045216 25 17 0,000 0,09915093 0,13930796 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,09915093 0,13922291 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,09915093 0,13913797 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,09915093 0,13905313 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,09915093 0,13896839 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,09915093 0,13888376 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,09915093 0,13879923 ! cellular defense response GO:0006968 102 87 1,000 0,09939043 0,13904988 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,09939043 0,13896535 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 1,000 0,09939043 0,13888092 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,09939043 0,1387966 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,10131119 0,14139304 ! establishment of RNA localization GO:0051236 128 88 1,000 0,10131119 0,1413073 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 1,000 0,10131119 0,14122166 ! reproductive developmental process GO:0003006 127 89 1,000 0,10324229 0,14382633 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,10324229 0,14373927 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,10467001 0,14563886 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,10467001 0,14555081 ! positive regulation of translation GO:0045727 28 18 0,000 0,10467001 0,14546286 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,10467001 0,14537502 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,10467001 0,14528729 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,10467001 0,14519966 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,10467001 0,14511214 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,10467001 0,14502472 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,10467001 0,14493741 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,10467001 0,1448502 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,10467001 0,1447631 GO:0050886|endocrine process, ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,10467001 0,1446761 ! glutamine metabolic process GO:0006541 23 18 0,000 0,10467001 0,14458921 ! pigmentation during development GO:0048066 31 18 0,000 0,10467001 0,14450242 ! central nervous system neuron development GO:0021954 30 18 0,000 0,10467001 0,14441574 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,10467001 0,14432916 ! fucose metabolic process GO:0006004 26 18 0,000 0,10467001 0,14424268 ! response to fungus GO:0009620 19 18 0,000 0,10467001 0,14415631 ! peptide cross-linking GO:0018149 31 18 0,000 0,10467001 0,14407004 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,10467001 0,14398387 ! heart process GO:0003015 27 18 0,000 0,10467001 0,14389781 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,10467001 0,14381185 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,10467001 0,14372599 ! visual learning GO:0008542 35 18 0,000 0,10467001 0,14364023 ! somitogenesis GO:0001756 24 18 0,000 0,10467001 0,14355458 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,10467001 0,14346903 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,10467001 0,14338358 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,10467001 0,14329823 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,10467001 0,14321299 ! vitamin transport GO:0051180 24 18 0,000 0,10467001 0,14312784 ! hormone transport GO:0009914 27 18 0,000 0,10467001 0,1430428 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,10467001 0,14295786 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,10467001 0,14287302 ! cell-cell recognition GO:0009988 20 18 0,000 0,10467001 0,14278828 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,10467001 0,14270363 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,10467001 0,14261909 ! regulation of glucose import GO:0046324 21 18 0,000 0,10467001 0,14253465 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,10467001 0,14245031 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,10467001 0,14236607 ! leukocyte differentiation GO:0002521 143 90 1,000 0,10518355 0,14298001 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,10518355 0,14289555 ! RNA localization GO:0006403 135 91 1,000 0,10713477 0,14546043 ! response to virus GO:0009615 122 91 1,000 0,10713477 0,14537462 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,10909576 0,14794826 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,10909576 0,14786108 ! cell fate commitment GO:0045165 141 92 1,000 0,10909576 0,147774 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,1101556 0,14912177 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,1101556 0,14903405 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,1101556 0,14894643 ! positive regulation of ossification GO:0045778 30 19 0,000 0,1101556 0,14885892 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,1101556 0,14877151 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,1101556 0,1486842 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,1101556 0,148597 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,1101556 0,1485099 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,1101556 0,1484229 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,1101556 0,148336 ! regeneration GO:0031099 32 19 0,000 0,1101556 0,1482492 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,1101556 0,14816251 ! sensory perception of taste GO:0050909 23 19 0,000 0,1101556 0,14807591 ! smooth muscle contraction GO:0006939 36 19 0,000 0,1101556 0,14798942 ! peroxisome organization GO:0007031 29 19 0,000 0,1101556 0,14790303 ! digestive system process GO:0022600 30 19 0,000 0,1101556 0,14781674 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,1101556 0,14773054 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,1101556 0,14764445 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,1101556 0,14755847 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,1101556 0,14747258 ! sex determination GO:0007530 29 19 0,000 0,1101556 0,14738679 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,1101556 0,1473011 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,1101556 0,14721551 ! cytolysis GO:0019835 20 19 0,000 0,1101556 0,14713001 ! renal system process GO:0003014 35 19 0,000 0,1101556 0,14704462 ! vasodilation GO:0042311 33 19 0,000 0,1101556 0,14695933 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,1101556 0,14687414 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,1101556 0,14678904 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,1101556 0,14670404 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,1101556 0,14661915 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,1101556 0,14653435 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,1101556 0,14644964 ! sarcomere organization GO:0045214 23 19 0,000 0,1101556 0,14636504 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,1101556 0,14628053 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,1101556 0,14619612 GO:0043450|alkene biosynthetic process, ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,1101556 0,14611181 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,1101556 0,1460276 ! protein stabilization GO:0050821 26 19 0,000 0,1101556 0,14594348 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,11106633 0,14706537 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,11560789 0,15299088 ! iron ion transport GO:0006826 37 20 0,000 0,11560789 0,15290291 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,11560789 0,15281503 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,11560789 0,15272726 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,11560789 0,15263958 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,11560789 0,15255201 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,11560789 0,15246454 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,11560789 0,15237716 ! spinal cord development GO:0021510 31 20 0,000 0,11560789 0,15228989 ! response to ethanol GO:0045471 37 20 0,000 0,11560789 0,15220272 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,11560789 0,15211565 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,11560789 0,15202868 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,11560789 0,1519418 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,11560789 0,15185503 ! chromosome condensation GO:0030261 31 20 0,000 0,11560789 0,15176835 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,11560789 0,15168178 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,11560789 0,1515953 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,11560789 0,15150892 ! DNA modification GO:0006304 28 20 0,000 0,11560789 0,15142264 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,11560789 0,15133646 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,11560789 0,15125037 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,11560789 0,15116438 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,11560789 0,1510785 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,11560789 0,1509927 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,11560789 0,15090701 ! collagen catabolic process GO:0030574 25 20 0,000 0,11560789 0,15082141 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,11560789 0,15073591 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,11560789 0,15065051 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,11560789 0,15056521 ! alditol metabolic process GO:0019400 24 20 0,000 0,11560789 0,15048 ! actin filament-based movement GO:0030048 34 20 0,000 0,11560789 0,15039488 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,11703363 0,15216357 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,11703363 0,1520776 ! protein maturation GO:0051604 129 96 1,000 0,11703363 0,15199173 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,11904065 0,15451101 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,12102709 0,15700073 ! regulation of cell killing GO:0031341 34 21 0,000 0,12102709 0,15691223 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,12102709 0,15682383 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,12102709 0,15673553 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,12102709 0,15664733 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,12102709 0,15655922 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,12102709 0,15647122 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,12102709 0,15638331 ! protein amino acid acylation GO:0043543 37 21 0,000 0,12102709 0,15629551 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,12102709 0,1562078 ! vesicle docking GO:0048278 27 21 0,000 0,12102709 0,15612019 ! phototransduction GO:0007602 25 21 0,000 0,12102709 0,15603268 ! dendrite development GO:0016358 35 21 0,000 0,12102709 0,15594526 ! visual behavior GO:0007632 39 21 0,000 0,12102709 0,15585795 ! ovarian follicle development GO:0001541 30 21 0,000 0,12102709 0,15577073 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,12102709 0,15568361 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,12102709 0,15559659 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,12102709 0,15550966 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,12102709 0,15542284 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,12102709 0,1553361 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,12102709 0,15524947 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,12102709 0,15516293 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,12102709 0,15507649 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,12102709 0,15499014 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,12102709 0,15490389 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,12102709 0,15481774 ! fatty acid transport GO:0015908 30 21 0,000 0,12102709 0,15473168 ! platelet activation GO:0030168 28 21 0,000 0,12102709 0,15464572 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,12102709 0,15455985 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,12102709 0,15447408 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,12102709 0,15438841 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,12102709 0,15430283 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,12102709 0,15421734 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,12102709 0,15413195 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,12102709 0,15404665 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,12102709 0,15396145 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,12102709 0,15387634 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,12102709 0,15379132 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,12102709 0,1537064 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,12102709 0,15362158 ! calcium ion transport GO:0006816 167 99 1,000 0,12308049 0,15614183 ! extracellular structure organization GO:0043062 156 99 1,000 0,12308049 0,15605575 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,12511296 0,15854535 ! divalent metal ion transport GO:0070838 171 100 1,000 0,12511296 0,15845804 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,12641338 0,16001694 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,12641338 0,15992892 ! viral genome replication GO:0019079 29 22 0,000 0,12641338 0,159841 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,12641338 0,15975317 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,12641338 0,15966545 ! leukocyte adhesion GO:0007159 38 22 0,000 0,12641338 0,15957781 ! molting cycle process GO:0022404 40 22 0,000 0,12641338 0,15949028 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,12641338 0,15940284 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,12641338 0,15931549 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,12641338 0,15922825 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,12641338 0,15914109 ! vasculogenesis GO:0001570 33 22 0,000 0,12641338 0,15905404 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,12641338 0,15896707 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,12641338 0,15888021 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,12641338 0,15879343 ! lysosome organization GO:0007040 37 22 0,000 0,12641338 0,15870676 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,12641338 0,15862017 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,12641338 0,15853368 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,12641338 0,15844729 ! regulation of behavior GO:0050795 38 22 0,000 0,12641338 0,15836099 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,12641338 0,15827478 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,12641338 0,15818867 ! membrane depolarization GO:0051899 35 22 0,000 0,12641338 0,15810265 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,12641338 0,15801673 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,12641338 0,15793089 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,12641338 0,15784516 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,12641338 0,15775951 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,12641338 0,15767396 ! blastocyst development GO:0001824 37 22 0,000 0,12641338 0,1575885 ! neural tube closure GO:0001843 33 22 0,000 0,12641338 0,15750313 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,13176698 0,16408449 ! neuron fate commitment GO:0048663 32 23 0,000 0,13176698 0,1639957 ! embryonic pattern specification GO:0009880 31 23 0,000 0,13176698 0,163907 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,13176698 0,1638184 ! vesicle targeting GO:0006903 32 23 0,000 0,13176698 0,1637299 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,13176698 0,16364149 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,13176698 0,16355318 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,13176698 0,16346497 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,13176698 0,16337684 ! interaction with host GO:0051701 37 23 0,000 0,13176698 0,16328882 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,13176698 0,16320089 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,13176698 0,16311305 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,13176698 0,16302531 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,13176698 0,16293766 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,13176698 0,1628501 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,13176698 0,16276265 ! cell fate determination GO:0001709 45 23 0,000 0,13176698 0,16267528 ! pentose metabolic process GO:0019321 31 23 0,000 0,13176698 0,16258801 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,13176698 0,16250083 ! spermatid development GO:0007286 33 23 0,000 0,13176698 0,16241374 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,13176698 0,16232675 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,13176698 0,16223985 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,13176698 0,16215305 ! telomere organization GO:0032200 32 23 0,000 0,13176698 0,16206633 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,13176698 0,16197971 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,13176698 0,16189319 ! regulation of amine transport GO:0051952 38 23 0,000 0,13176698 0,16180675 ! liver development GO:0001889 40 23 0,000 0,13176698 0,16172041 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,13708807 0,16816136 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,13708807 0,16807172 ! initiation of viral infection GO:0019059 42 24 0,000 0,13708807 0,16798218 ! superoxide metabolic process GO:0006801 32 24 0,000 0,13708807 0,16789273 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,13708807 0,16780338 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,13708807 0,16771413 ! sperm motility GO:0030317 27 24 0,000 0,13708807 0,16762496 ! vacuole organization GO:0007033 39 24 0,000 0,13708807 0,1675359 ! receptor metabolic process GO:0043112 37 24 0,000 0,13708807 0,16744692 ! neural crest cell development GO:0014032 39 24 0,000 0,13708807 0,16735804 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,13708807 0,16726926 ! primary neural tube formation GO:0014020 35 24 0,000 0,13708807 0,16718057 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,13708807 0,16709197 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,13708807 0,16700347 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,13708807 0,16691506 ! glutathione metabolic process GO:0006749 29 24 0,000 0,13708807 0,16682675 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,13708807 0,16673853 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,13708807 0,1666504 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,14237685 0,17298825 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,14237685 0,17289691 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,14237685 0,17280568 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,14237685 0,17271453 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,14237685 0,17262349 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,14237685 0,17253254 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,14237685 0,17244168 ! peptide transport GO:0015833 43 25 0,000 0,14237685 0,17235092 ! male gonad development GO:0008584 33 25 0,000 0,14237685 0,17226026 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,14237685 0,17216969 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,14237685 0,17207922 ! phospholipid transport GO:0015914 35 25 0,000 0,14237685 0,17198884 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,14237685 0,17189856 ! detection of light stimulus GO:0009583 30 25 0,000 0,14237685 0,17180837 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,14237685 0,17171828 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,14237685 0,17162828 ! leukocyte proliferation GO:0070661 39 25 0,000 0,14237685 0,17153837 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,14763352 0,17777858 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,14763352 0,17768556 ! translational initiation GO:0006413 43 26 0,000 0,14763352 0,17759262 ! circadian rhythm GO:0007623 42 26 0,000 0,14763352 0,17749979 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,14763352 0,17740705 ! post-embryonic development GO:0009791 42 26 0,000 0,14763352 0,17731441 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,14763352 0,17722187 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,14763352 0,17712942 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,14763352 0,17703707 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,14763352 0,17694481 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,14763352 0,17685265 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,14763352 0,17676059 ! regulation of coagulation GO:0050818 39 26 0,000 0,14763352 0,17666862 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,15285827 0,1828258 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,15285827 0,18273078 ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,15285827 0,18263585 ! membrane docking GO:0022406 39 27 0,000 0,15285827 0,18254103 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,15285827 0,1824463 ! catechol metabolic process GO:0009712 43 27 0,000 0,15285827 0,18235167 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,15285827 0,18225714 ! acute-phase response GO:0006953 42 27 0,000 0,15285827 0,1821627 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,15285827 0,18206837 ! myofibril assembly GO:0030239 36 27 0,000 0,15285827 0,18197413 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,15285827 0,18187999 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,15285827 0,18178595 ! natural killer cell activation GO:0030101 35 27 0,000 0,15285827 0,181692 ! lipid oxidation GO:0034440 38 27 0,000 0,15285827 0,18159815 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,15285827 0,1815044 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,15285827 0,18141074 ! gene silencing GO:0016458 41 27 0,000 0,15285827 0,18131718 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,15805129 0,18738039 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,15805129 0,18728386 ! phenol metabolic process GO:0018958 44 28 0,000 0,15805129 0,18718742 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,15805129 0,18709108 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,15805129 0,18699484 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,15805129 0,1868987 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,15805129 0,18680265 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,15805129 0,18670671 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,15805129 0,18661086 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,15805129 0,18651512 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,15805129 0,18641947 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,15805129 0,18632392 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,15805129 0,18622847 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,15805129 0,18613311 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,15805129 0,18603785 ! mesoderm formation GO:0001707 46 28 0,000 0,15805129 0,18594269 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,15805129 0,18584763 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,15805129 0,18575266 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,15805129 0,1856578 ! BMP signaling pathway GO:0030509 40 28 0,000 0,15805129 0,18556302 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,15805129 0,18546835 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,15805129 0,18537377 ! neural tube formation GO:0001841 41 28 0,000 0,15805129 0,18527929 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,15805129 0,1851849 ! placenta development GO:0001890 37 28 0,000 0,15805129 0,18509061 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,16321277 0,19103785 ! regulation of innate immune response GO:0045088 38 29 0,000 0,16321277 0,19094068 ! ovulation cycle process GO:0022602 41 29 0,000 0,16321277 0,19084361 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,16321277 0,19074663 ! protein targeting to membrane GO:0006612 53 29 0,000 0,16321277 0,19064976 ! muscle cell development GO:0055001 38 29 0,000 0,16321277 0,19055298 ! formation of primary germ layer GO:0001704 48 29 0,000 0,16321277 0,1904563 ! eye morphogenesis GO:0048592 51 29 0,000 0,16321277 0,19035972 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,16321277 0,19026324 ! collagen metabolic process GO:0032963 40 30 0,000 0,16834291 0,19614422 ! organic anion transport GO:0015711 51 30 0,000 0,16834291 0,1960449 ! cholesterol transport GO:0030301 46 30 0,000 0,16834291 0,19594569 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,16834291 0,19584658 ! spindle organization GO:0007051 37 30 0,000 0,16834291 0,19574756 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,16834291 0,19564865 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,16834291 0,19554984 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,16834291 0,19545113 ! ceramide metabolic process GO:0006672 43 30 0,000 0,16834291 0,19535251 ! ovulation cycle GO:0042698 43 30 0,000 0,16834291 0,195254 ! hindbrain development GO:0030902 45 30 0,000 0,16834291 0,19515559 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,16834291 0,19505727 ! adult locomotory behavior GO:0008344 47 30 0,000 0,16834291 0,19495905 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,16834291 0,19486094 ! response to heat GO:0009408 41 30 0,000 0,16834291 0,19476292 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,16834291 0,194665 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,16834291 0,19456718 ! negative regulation of secretion GO:0051048 49 31 0,000 0,17344188 0,20035978 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,17344188 0,2002592 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,17344188 0,20015872 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,17344188 0,20005834 ! odontogenesis GO:0042476 50 31 0,000 0,17344188 0,19995806 ! segmentation GO:0035282 41 31 0,000 0,17344188 0,19985788 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,17344188 0,1997578 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,17344188 0,19965782 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,17344188 0,19955794 ! cell fate specification GO:0001708 37 31 0,000 0,17344188 0,19945816 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,17344188 0,19935848 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,17344188 0,1992589 ! regulation of muscle development GO:0048634 48 32 0,000 0,17850988 0,2049789 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,17850988 0,20487661 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,17850988 0,20477443 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,17850988 0,20467235 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,17850988 0,20457037 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,17850988 0,20446849 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 0,000 0,17850988 0,20436672 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,17850988 0,20426504 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,17850988 0,20416347 ! vesicle localization GO:0051648 47 32 0,000 0,17850988 0,20406199 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,1835471 0,20971601 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,1835471 0,20961188 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,1835471 0,20950786 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,1835471 0,20940393 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,1835471 0,20930011 ! sister chromatid segregation GO:0000819 46 33 0,000 0,1835471 0,2091964 ! actomyosin structure organization GO:0031032 43 33 0,000 0,1835471 0,20909278 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,1835471 0,20898927 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,1835471 0,20888586 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,1835471 0,20878256 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,1835471 0,20867935 ! female gonad development GO:0008585 49 33 0,000 0,1835471 0,20857625 ! positive regulation of cell development GO:0010720 54 33 0,000 0,1835471 0,20847325 ! lipid homeostasis GO:0055088 55 33 0,000 0,1835471 0,20837035 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,1835471 0,20826755 ! regulation of proteolysis GO:0030162 50 33 0,000 0,1835471 0,20816486 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,1835471 0,20806226 ! cytokinesis GO:0000910 52 33 0,000 0,1835471 0,20795977 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,1835471 0,20785738 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,18855372 0,21342202 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,18855372 0,21331704 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,18855372 0,21321217 ! feeding behavior GO:0007631 45 34 0,000 0,18855372 0,2131074 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,18855372 0,21300273 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,18855372 0,21289816 ! neuron migration GO:0001764 46 34 0,000 0,18855372 0,21279369 ! female gamete generation GO:0007292 43 34 0,000 0,18855372 0,21268933 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,18855372 0,21258507 ! polyol metabolic process GO:0019751 44 34 0,000 0,18855372 0,21248092 ! aerobic respiration GO:0009060 47 34 0,000 0,18855372 0,21237686 ! embryonic organ development GO:0048568 45 34 0,000 0,18855372 0,21227291 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,19352992 0,2177685 ! Notch signaling pathway GO:0007219 56 35 0,000 0,19352992 0,21766201 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,19352992 0,21755563 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,19352992 0,21744935 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,19352992 0,21734317 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,19352992 0,2172371 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,19352992 0,21713113 ! glycogen metabolic process GO:0005977 48 35 0,000 0,19352992 0,21702526 ! pigment metabolic process GO:0042440 61 35 0,000 0,19352992 0,2169195 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,19352992 0,21681384 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,19352992 0,21670828 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,19847589 0,22213846 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,19847589 0,22203042 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,19847589 0,22192248 ! organic ether metabolic process GO:0018904 46 36 0,000 0,19847589 0,22181464 ! tissue remodeling GO:0048771 62 36 0,000 0,19847589 0,22170692 ! neural tube development GO:0021915 50 36 0,000 0,19847589 0,22159929 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,19847589 0,22149177 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,19847589 0,22138435 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,19847589 0,22127704 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,19847589 0,22116983 ! glucan metabolic process GO:0044042 49 36 0,000 0,19847589 0,22106273 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,2033918 0,22642843 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,2033918 0,22631889 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,2033918 0,22620945 ! learning GO:0007612 67 37 0,000 0,2033918 0,22610012 ! ion transmembrane transport GO:0034220 56 37 0,000 0,2033918 0,22599089 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,2033918 0,22588177 ! regulation of protein secretion GO:0050708 51 37 0,000 0,2033918 0,22577275 ! amino acid activation GO:0043038 52 37 0,000 0,2033918 0,22566384 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,2033918 0,22555504 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,20827785 0,23086219 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,20827785 0,23075099 ! phagocytosis GO:0006909 60 38 0,000 0,20827785 0,23063989 ! mesenchymal cell development GO:0014031 64 38 0,000 0,20827785 0,2305289 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,2131342 0,23579061 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,2131342 0,23567725 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,2131342 0,23556399 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,2131342 0,23545085 ! male sex differentiation GO:0046661 53 39 0,000 0,2131342 0,23533782 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,2131342 0,23522489 ! chromatin remodeling GO:0006338 68 39 0,000 0,2131342 0,23511207 ! developmental growth GO:0048589 62 39 0,000 0,2131342 0,23499936 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,21796105 0,24020623 ! regulation of tube size GO:0035150 60 40 0,000 0,21796105 0,24009119 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,21796105 0,23997626 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,21796105 0,23986144 ! peptide metabolic process GO:0006518 56 40 0,000 0,21796105 0,23974673 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,21796105 0,23963213 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,21796105 0,23951764 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,21796105 0,23940325 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,22275856 0,24455594 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,22275856 0,24443926 ! endosome transport GO:0016197 71 41 0,000 0,22275856 0,24432269 ! striated muscle contraction GO:0006941 62 41 0,000 0,22275856 0,24420624 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,22275856 0,24408989 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,22752691 0,24919614 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,22752691 0,24907753 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,22752691 0,24895904 ! excretion GO:0007588 63 42 0,000 0,22752691 0,24884065 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,22752691 0,24872238 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,22752691 0,24860423 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,22752691 0,24848618 ! regulation of cell shape GO:0008360 78 42 0,000 0,22752691 0,24836825 ! leukocyte migration GO:0050900 60 43 0,000 0,23226628 0,25342146 ! neuromuscular process GO:0050905 79 43 0,000 0,23226628 0,2533013 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,23226628 0,25318125 ! tRNA processing GO:0008033 49 43 0,000 0,23226628 0,25306132 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,23226628 0,2529415 ! vesicle organization GO:0016050 79 43 0,000 0,23226628 0,25282179 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,23226628 0,2527022 ! glycolysis GO:0006096 53 44 0,000 0,23697684 0,25770532 ! regulation of ion transport GO:0043269 57 44 0,000 0,23697684 0,25758353 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,23697684 0,25746185 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,23697684 0,25734029 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,23697684 0,25721885 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,23697684 0,25709752 ! positive regulation of defense response GO:0031349 59 45 0,000 0,24165877 0,26205336 ! regulation of translational initiation GO:0006446 64 45 0,000 0,24165877 0,26192987 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,24165877 0,26180649 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,24165877 0,26168323 ! cell recognition GO:0008037 58 45 0,000 0,24165877 0,26156008 ! cell redox homeostasis GO:0045454 63 46 0,000 0,24631224 0,26647138 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,24631224 0,2663461 ! regulation of ossification GO:0030278 71 46 0,000 0,24631224 0,26622094 ! histone modification GO:0016570 68 46 0,000 0,24631224 0,26609589 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,24631224 0,26597096 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,25093742 0,27083813 ! viral infectious cycle GO:0019058 71 47 0,000 0,25093742 0,2707111 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,25093742 0,27058418 ! covalent chromatin modification GO:0016569 75 47 0,000 0,25093742 0,27045739 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,25093742 0,27033071 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,25093742 0,27020415 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,25093742 0,27007771 ! chloride transport GO:0006821 67 48 0,000 0,25553448 0,27489677 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,25553448 0,27476825 ! response to temperature stimulus GO:0009266 62 48 0,000 0,25553448 0,27463986 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,25553448 0,27451158 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,25553448 0,27438342 ! gastrulation GO:0007369 73 48 0,000 0,25553448 0,27425539 ! heart morphogenesis GO:0003007 65 48 0,000 0,25553448 0,27412747 ! regulation of endocytosis GO:0030100 63 48 0,000 0,25553448 0,27399967 ! nuclear export GO:0051168 69 48 0,000 0,25553448 0,27387199 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,25553448 0,27374443 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,26010358 0,27850942 ! sensory perception of smell GO:0007608 61 49 0,000 0,26010358 0,27837982 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,26010358 0,27825034 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,26010358 0,27812099 ! RNA elongation GO:0006354 62 49 0,000 0,26010358 0,27799175 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,26010358 0,27786263 ! germ cell development GO:0007281 68 49 0,000 0,26010358 0,27773363 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,26010358 0,27760475 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,26010358 0,27747599 ! cartilage development GO:0051216 70 49 0,000 0,26010358 0,27734735 ! regulation of actin filament length GO:0030832 72 50 0,000 0,26464491 0,28205898 ! positive regulation of growth GO:0045927 67 50 0,000 0,26464491 0,28192834 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,26464491 0,28179782 ! proton transport GO:0015992 75 50 0,000 0,26464491 0,28166742 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,26464491 0,28153714 ! positive regulation of secretion GO:0051047 71 51 0,000 0,26915862 0,28620657 ! hydrogen transport GO:0006818 77 51 0,000 0,26915862 0,28607432 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,26915862 0,28594218 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,26915862 0,28581017 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,26915862 0,28567827 ! adult behavior GO:0030534 80 51 0,000 0,26915862 0,2855465 ! transition metal ion transport GO:0000041 74 52 0,000 0,27364488 0,29017207 ! regulation of cellular component size GO:0032535 74 52 0,000 0,27364488 0,29003835 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,27364488 0,28990475 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,27364488 0,28977128 ! establishment of organelle localization GO:0051656 85 52 0,000 0,27364488 0,28963793 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,27810386 0,29422211 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,27810386 0,29408684 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,27810386 0,29395169 ! single fertilization GO:0007338 59 53 0,000 0,27810386 0,29381666 ! cell projection assembly GO:0030031 76 53 0,000 0,27810386 0,29368176 ! amino acid transport GO:0006865 84 54 0,000 0,28253572 0,29822494 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,28253572 0,29808814 ! regulation of mitosis GO:0007088 84 54 0,000 0,28253572 0,29795147 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,28253572 0,29781492 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,28253572 0,29767849 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,28253572 0,29754219 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,28253572 0,29740602 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,28253572 0,29726997 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,28253572 0,29713404 ! exocytosis GO:0006887 74 55 0,000 0,28694062 0,30162863 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,28694062 0,30149083 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,28694062 0,30135317 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,29131873 0,30581154 ! chromosome segregation GO:0007059 83 57 0,000 0,29567021 0,31023791 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,29567021 0,31009644 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,29567021 0,3099551 ! camera-type eye development GO:0043010 88 57 0,000 0,29567021 0,30981389 ! secondary metabolic process GO:0019748 84 57 0,000 0,29567021 0,30967281 ! gonad development GO:0008406 79 57 0,000 0,29567021 0,30953186 ! viral reproductive process GO:0022415 87 58 0,000 0,29999522 0,31391675 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,29999522 0,31377399 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,30429392 0,31812546 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,30856647 0,32244565 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,30856647 0,32229922 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,30856647 0,32215292 ! regulation of heart contraction GO:0008016 91 60 0,000 0,30856647 0,32200675 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,30856647 0,32186071 ! fertilization GO:0009566 68 60 0,000 0,30856647 0,32171481 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,31281302 0,32599453 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,31281302 0,32584689 ! extracellular matrix organization GO:0030198 103 61 0,000 0,31281302 0,32569938 ! amine catabolic process GO:0009310 90 62 0,000 0,31703373 0,3299446 ! neurotransmitter transport GO:0006836 81 62 0,000 0,31703373 0,32979537 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,31703373 0,32964628 ! organelle localization GO:0051640 96 62 0,000 0,31703373 0,32949732 ! viral reproduction GO:0016032 92 63 0,000 0,32122876 0,33370648 ! regulation of lipase activity GO:0060191 109 63 0,000 0,32122876 0,33355582 ! appendage morphogenesis GO:0035107 93 64 0,000 0,32539826 0,33773285 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,32539826 0,33758051 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,32539826 0,33742831 ! hexose catabolic process GO:0019320 82 64 0,000 0,32539826 0,33727625 ! appendage development GO:0048736 94 65 0,000 0,32954238 0,34141778 GO:0060173|limb development, ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,32954238 0,34126406 ! activation of immune response GO:0002253 83 65 0,000 0,32954238 0,34111048 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,33366129 0,3452186 ! antigen processing and presentation GO:0019882 96 66 0,000 0,33366129 0,34506338 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,33366129 0,3449083 ! regulation of immune effector process GO:0002697 101 66 0,000 0,33366129 0,34475335 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,33775512 0,34882657 ! acute inflammatory response GO:0002526 92 68 0,000 0,34182404 0,35287042 ! learning or memory GO:0007611 123 68 0,000 0,34182404 0,35271211 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,34182404 0,35255394 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,34182404 0,35239592 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,34182404 0,35223803 ! rhythmic process GO:0048511 105 68 0,000 0,34182404 0,35208029 ! inorganic anion transport GO:0015698 93 68 0,000 0,34182404 0,35192269 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,34586819 0,355927 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,34988772 0,3599024 ! humoral immune response GO:0006959 86 70 0,000 0,34988772 0,35974151 ! eye development GO:0001654 111 70 0,000 0,34988772 0,35958077 ! amine transport GO:0015837 101 70 0,000 0,34988772 0,35942017 ! regulation of catabolic process GO:0009894 106 70 0,000 0,34988772 0,35925971 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,35388278 0,36319964 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,35388278 0,36303765 ! response to hypoxia GO:0001666 132 72 0,000 0,35785352 0,36694744 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,35785352 0,36678391 ! regulation of blood pressure GO:0008217 107 73 0,000 0,36180009 0,37066379 ! tube morphogenesis GO:0035239 118 73 0,000 0,36180009 0,37049875 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,36180009 0,37033387 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,36180009 0,37016913 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,36572262 0,37401602 ! response to oxygen levels GO:0070482 137 74 0,000 0,36572262 0,37384979 ! digestion GO:0007586 97 74 0,000 0,36572262 0,37368371 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,36572262 0,37351777 ! blood coagulation GO:0007596 116 75 0,000 0,36962127 0,37733197 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,36962127 0,37716456 ! tRNA metabolic process GO:0006399 95 76 0,000 0,37349618 0,38094954 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,37734749 0,3847071 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,37734749 0,38453665 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,38117534 0,38826541 ! cellular respiration GO:0045333 107 79 0,000 0,38497988 0,39196712 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,38497988 0,39179369 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,38497988 0,3916204 ! chromatin assembly GO:0031497 102 80 0,000 0,38876125 0,39529217 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,38876125 0,39511749 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,38876125 0,39494297 ! hemostasis GO:0007599 125 81 0,000 0,39251959 0,39858501 ! regulation of neurological system process GO:0031644 122 81 0,000 0,39251959 0,39840911 ! vitamin metabolic process GO:0006766 103 81 0,000 0,39251959 0,39823337 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,39251959 0,39805778 GO:0002696|positive regulation of leukocyte activation, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,39996771 0,40543223 ! regulation of defense response GO:0031347 117 84 0,000 0,40365778 0,40899246 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,40365778 0,40881237 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,40365778 0,40863243 ! sterol metabolic process GO:0016125 120 84 0,000 0,40365778 0,40845266 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,40732536 0,41198256 ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,40732536 0,41180146 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,40732536 0,41162053 ! nucleosome organization GO:0034728 114 87 0,000 0,41459362 0,41878144 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,41459362 0,4185976 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,41819457 0,42204805 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,41819457 0,42186294 GO:0016054|organic acid catabolic process, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,42177357 0,42528681 ! hormone metabolic process GO:0042445 121 90 0,000 0,42533077 0,4286857 ! ATP metabolic process GO:0046034 137 91 0,000 0,42886628 0,43205976 ! positive regulation of immune response GO:0050778 121 92 0,000 0,43238024 0,43540917 ! sulfur metabolic process GO:0006790 118 92 0,000 0,43238024 0,43521862 ! peptidyl-amino acid modification GO:0018193 147 93 0,000 0,43587278 0,43854217 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,43587278 0,43835041 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,43587278 0,43815883 ! electron transport chain GO:0022900 123 94 0,000 0,43934403 0,44145534 ! response to oxidative stress GO:0006979 141 94 0,000 0,43934403 0,44126257 ! angiogenesis GO:0001525 149 95 0,000 0,44279412 0,4445336 ! carboxylic acid transport GO:0046942 147 95 0,000 0,44279412 0,44433965 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,44622318 0,4475854 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,44622318 0,44739029 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,44963133 0,45061092 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! regulation of translation GO:0006417 151 100 0,000 0,45973161 0,46053253 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,45973161 0,46033204 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,45973161 0,46013172 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,45973161 0,45993158 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,45973161 0,45973161