pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6376-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 7,965E-09 1,832E-05 ! protein amino acid autophosphorylation GO:0046777 80 45 5,000 1,665E-08 1,915E-05 ! response to UV GO:0009411 75 46 5,000 1,91E-08 1,464E-05 ! negative regulation of transport GO:0051051 116 73 5,000 3,205E-07 1,843E-04 ! regulation of DNA replication GO:0006275 75 48 4,000 9,929E-07 4,567E-04 ! regulation of fibroblast proliferation GO:0048145 35 22 3,000 1,288E-06 4,936E-04 ! positive regulation of cell migration GO:0030335 92 51 4,000 1,35E-06 4,437E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 1,554E-06 4,468E-04 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 1,554E-06 3,972E-04 ! response to light stimulus GO:0009416 153 96 5,000 1,631E-06 3,752E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,78E-06 3,721E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 1,86E-06 3,565E-04 ! positive regulation of cell motion GO:0051272 99 56 4,000 2,164E-06 3,829E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 2,208E-06 3,627E-04 GO:0045936|negative regulation of phosphate metabolic process, ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 2,208E-06 3,385E-04 ! induction of positive chemotaxis GO:0050930 14 8 2,000 2,84E-06 4,082E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 2,84E-06 3,842E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,84E-06 3,628E-04 ! positive regulation of catabolic process GO:0009896 40 28 3,000 3,543E-06 4,289E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 3,902E-06 4,487E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 4,248E-06 4,652E-04 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 2,000 6,052E-06 6,327E-04 ! response to X-ray GO:0010165 16 10 2,000 6,052E-06 6,052E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 6,052E-06 5,8E-04 ! regulation of catabolic process GO:0009894 106 70 4,000 6,583E-06 6,056E-04 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 7,89E-06 6,979E-04 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 8,299E-06 7,069E-04 GO:0050927|positive regulation of positive chemotaxis, ! chondrocyte differentiation GO:0002062 17 11 2,000 8,299E-06 6,817E-04 ! negative regulation of glucose import GO:0046325 14 11 2,000 8,299E-06 6,582E-04 GO:0010829|negative regulation of glucose transport, ! response to gamma radiation GO:0010332 20 12 2,000 1,104E-05 8,46E-04 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,38E-05 1,024E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,431E-05 1,028E-03 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 1,708E-05 1,19E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 1,708E-05 1,155E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 1,862E-05 1,223E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 2,047E-05 1,308E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 2,264E-05 1,407E-03 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 2,644E-05 1,6E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,779E-05 1,639E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 3,365E-05 1,935E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 3,365E-05 1,888E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 3,365E-05 1,843E-03 ! regulation of intracellular transport GO:0032386 78 49 3,000 3,455E-05 1,848E-03 ! positive regulation of DNA replication GO:0045740 29 18 2,000 4,027E-05 2,105E-03 ! regulation of glucose import GO:0046324 21 18 2,000 4,027E-05 2,058E-03 GO:0010827|regulation of glucose transport, ! regulation of protein catabolic process GO:0042176 77 51 3,000 4,052E-05 2,026E-03 ! positive regulation of protein catabolic process GO:0045732 23 19 2,000 4,769E-05 2,334E-03 ! positive regulation of fibroblast proliferation GO:0048146 27 19 2,000 4,769E-05 2,285E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 4,769E-05 2,239E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 4,769E-05 2,194E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 5,596E-05 2,524E-03 ! positive regulation of locomotion GO:0040017 35 20 2,000 5,596E-05 2,475E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 2,000 5,596E-05 2,428E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 6,296E-05 2,682E-03 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 6,296E-05 2,633E-03 ! regulation of chemotaxis GO:0050920 36 21 2,000 6,511E-05 2,674E-03 ! cell aging GO:0007569 32 21 2,000 6,511E-05 2,627E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 6,511E-05 2,582E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 6,744E-05 2,629E-03 ! lung development GO:0030324 94 59 3,000 7,213E-05 2,765E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 7,519E-05 2,835E-03 ! regulation of behavior GO:0050795 38 22 2,000 7,519E-05 2,789E-03 ! protein tetramerization GO:0051262 39 22 2,000 7,519E-05 2,745E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 8,224E-05 2,956E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 8,623E-05 3,051E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 8,623E-05 3,005E-03 ! interaction with host GO:0051701 37 23 2,000 8,623E-05 2,96E-03 ! respiratory tube development GO:0030323 99 62 3,000 8,767E-05 2,965E-03 ! receptor metabolic process GO:0043112 37 24 2,000 9,829E-05 3,276E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 9,829E-05 3,229E-03 ! respiratory system development GO:0060541 100 64 3,000 9,929E-05 3,216E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,256E-04 4,012E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 1,394E-04 4,391E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 1,394E-04 4,331E-03 ! epithelial cell proliferation GO:0050673 6 5 1,000 1,394E-04 4,273E-03 ! microvillus organization GO:0032528 7 5 1,000 1,394E-04 4,217E-03 GO:0030033|microvillus assembly, ! early endosome to late endosome transport GO:0045022 11 5 1,000 1,394E-04 4,162E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 1,394E-04 4,109E-03 ! centrosome duplication GO:0051298 5 5 1,000 1,394E-04 4,057E-03 ! response to UV-C GO:0010225 6 5 1,000 1,394E-04 4,006E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 1,394E-04 3,957E-03 ! regulation of sensory perception GO:0051931 6 5 1,000 1,394E-04 3,909E-03 GO:0051930|regulation of sensory perception of pain, ! positive regulation of phosphorylation GO:0042327 102 70 3,000 1,409E-04 3,904E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 1,409E-04 3,858E-03 ! negative regulation of protein transport GO:0051224 49 27 2,000 1,409E-04 3,812E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 1,572E-04 4,203E-03 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,574E-04 4,161E-03 ! cellular response to hormone stimulus GO:0032870 109 74 3,000 1,748E-04 4,568E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 2,085E-04 5,389E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 2,085E-04 5,329E-03 ! male meiosis GO:0007140 7 6 1,000 2,085E-04 5,27E-03 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 2,085E-04 5,213E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 2,085E-04 5,157E-03 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 2,085E-04 5,102E-03 GO:0031958|corticosteroid receptor signaling pathway, ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 2,085E-04 5,048E-03 ! ER overload response GO:0006983 7 6 1,000 2,085E-04 4,996E-03 ! male sex determination GO:0030238 9 6 1,000 2,085E-04 4,944E-03 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 1,000 2,085E-04 4,894E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 2,085E-04 4,844E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! receptor internalization GO:0031623 9 6 1,000 2,085E-04 4,796E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 2,085E-04 4,748E-03 ! blastocyst growth GO:0001832 15 6 1,000 2,085E-04 4,702E-03 ! mammary gland development GO:0030879 57 31 2,000 2,142E-04 4,783E-03 ! leukocyte chemotaxis GO:0030595 43 31 2,000 2,142E-04 4,737E-03 GO:0060326|cell chemotaxis, ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 2,357E-04 5,163E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 2,000 2,357E-04 5,115E-03 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 2,586E-04 5,559E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,912E-04 6,202E-03 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 2,912E-04 6,145E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 2,912E-04 6,089E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 2,912E-04 6,034E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 2,912E-04 5,98E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 2,912E-04 5,927E-03 ! response to tumor cell GO:0002347 12 7 1,000 2,912E-04 5,875E-03 ! positive regulation of ATPase activity GO:0032781 10 7 1,000 2,912E-04 5,824E-03 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 3,085E-04 6,118E-03 ! cell cycle arrest GO:0007050 150 86 3,000 3,118E-04 6,13E-03 ! reproductive developmental process GO:0003006 127 89 3,000 3,555E-04 6,93E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 3,873E-04 7,486E-03 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 3,873E-04 7,424E-03 ! multicellular organism growth GO:0035264 14 8 1,000 3,873E-04 7,363E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 3,873E-04 7,302E-03 ! induction of an organ GO:0001759 11 8 1,000 3,873E-04 7,243E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 3,873E-04 7,185E-03 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 4,595E-04 8,455E-03 ! double-strand break repair GO:0006302 67 40 2,000 4,595E-04 8,388E-03 ! endosome transport GO:0016197 71 41 2,000 4,945E-04 8,955E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 4,968E-04 8,927E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 4,968E-04 8,858E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 4,968E-04 8,789E-03 ! receptor clustering GO:0043113 15 9 1,000 4,968E-04 8,722E-03 ! motor axon guidance GO:0008045 14 9 1,000 4,968E-04 8,656E-03 ! oocyte differentiation GO:0009994 12 9 1,000 4,968E-04 8,591E-03 GO:0048599|oocyte development, ! localization within membrane GO:0051668 15 9 1,000 4,968E-04 8,527E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 5,694E-04 9,7E-03 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 5,694E-04 9,629E-03 ! leukocyte migration GO:0050900 60 43 2,000 5,694E-04 9,559E-03 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 6,094E-04 0,01015639 ! regulation of inflammatory response GO:0050727 60 44 2,000 6,094E-04 0,01008332 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 6,094E-04 0,01001129 ! regulation of B cell proliferation GO:0030888 15 10 1,000 6,195E-04 0,01010504 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 6,195E-04 0,01003388 ! pathogenesis GO:0009405 13 10 1,000 6,195E-04 9,964E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 6,195E-04 9,895E-03 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 6,195E-04 9,826E-03 ! regulation of sodium ion transport GO:0002028 15 10 1,000 6,195E-04 9,759E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 6,195E-04 9,693E-03 GO:0043470|regulation of carbohydrate catabolic process, ! developmental induction GO:0031128 13 10 1,000 6,195E-04 9,627E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 6,195E-04 9,562E-03 ! positive regulation of cell cycle GO:0045787 77 45 2,000 6,512E-04 9,984E-03 ! positive regulation of defense response GO:0031349 59 45 2,000 6,512E-04 9,918E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 7,401E-04 0,01119866 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! virus-host interaction GO:0019048 17 11 1,000 7,553E-04 0,01135421 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 7,553E-04 0,01128048 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 7,553E-04 0,0112077 GO:0000725|recombinational repair, ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 7,553E-04 0,01113586 ! regulation of mRNA processing GO:0050684 18 11 1,000 7,553E-04 0,01106493 ! regulation of intracellular pH GO:0051453 17 11 1,000 7,553E-04 0,0109949 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 7,553E-04 0,01092575 ! L-glutamate transport GO:0015813 16 11 1,000 7,553E-04 0,01085746 GO:0015800|acidic amino acid transport, ! nitric oxide metabolic process GO:0046209 14 11 1,000 7,553E-04 0,01079002 GO:0006809|nitric oxide biosynthetic process, ! male genitalia development GO:0030539 13 11 1,000 7,553E-04 0,01072342 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 7,553E-04 0,01065763 GO:0042130|negative regulation of T cell proliferation, ! regulation of muscle contraction GO:0006937 69 48 2,000 7,873E-04 0,01104145 ! cartilage development GO:0051216 70 49 2,000 8,364E-04 0,01165886 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 9,042E-04 0,01252745 ! dicarboxylic acid transport GO:0006835 22 12 1,000 9,042E-04 0,01245243 ! cell-cell junction assembly GO:0007043 18 12 1,000 9,042E-04 0,01237831 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 9,042E-04 0,01230507 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 9,042E-04 0,01223268 ! peptidyl-lysine modification GO:0018205 18 12 1,000 9,042E-04 0,01216115 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 9,403E-04 0,01257409 ! aging GO:0007568 79 52 2,000 9,952E-04 0,01323117 ! nucleotide-excision repair GO:0006289 64 52 2,000 9,952E-04 0,01315513 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,066E-03 0,01400957 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,066E-03 0,01392997 ! genitalia development GO:0048806 15 13 1,000 1,066E-03 0,01385127 ! regulation of cellular pH GO:0030641 20 13 1,000 1,066E-03 0,01377345 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,066E-03 0,01369651 ! regulation of calcium-mediated signaling GO:0050848 18 13 1,000 1,066E-03 0,01362041 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 1,235E-03 0,01569269 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 1,235E-03 0,01560647 ! regulation of S phase GO:0033261 18 14 1,000 1,241E-03 0,01559194 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 1,241E-03 0,0155072 ! startle response GO:0001964 21 14 1,000 1,241E-03 0,01542338 ! cellular response to starvation GO:0009267 21 14 1,000 1,241E-03 0,01534046 ! lysosomal transport GO:0007041 20 14 1,000 1,241E-03 0,01525843 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 1,241E-03 0,01517726 ! G1/S transition checkpoint GO:0031575 33 14 1,000 1,241E-03 0,01509696 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 1,241E-03 0,0150175 ! regulation of ATPase activity GO:0043462 18 14 1,000 1,241E-03 0,01493888 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 1,241E-03 0,01486107 ! viral reproductive process GO:0022415 87 58 2,000 1,367E-03 0,01629414 ! lipid phosphorylation GO:0046834 23 15 1,000 1,428E-03 0,01692932 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 1,428E-03 0,0168425 ! centrosome cycle GO:0007098 16 15 1,000 1,428E-03 0,01675657 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 1,428E-03 0,01667151 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 1,428E-03 0,01658731 ! regulation of heart contraction GO:0008016 91 60 2,000 1,508E-03 0,01743183 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,628E-03 0,01872171 ! protein amino acid acetylation GO:0006473 28 16 1,000 1,628E-03 0,01862857 ! mitotic chromosome condensation GO:0007076 25 16 1,000 1,628E-03 0,01853635 ! oogenesis GO:0048477 23 16 1,000 1,628E-03 0,01844503 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 1,628E-03 0,01835462 ! negative regulation of cell growth GO:0030308 106 62 2,000 1,658E-03 0,01860165 ! regulation of transcription factor activity GO:0051090 97 63 2,000 1,736E-03 0,0193848 GO:0090046|regulation of transcription regulator activity, ! viral reproduction GO:0016032 92 63 2,000 1,736E-03 0,01929116 ! negative regulation of cell size GO:0045792 108 64 2,000 1,817E-03 0,0200886 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 1,817E-03 0,01999248 ! signal complex assembly GO:0007172 29 17 1,000 1,841E-03 0,02015842 ! negative regulation of ion transport GO:0043271 20 17 1,000 1,841E-03 0,02006288 ! vacuolar transport GO:0007034 24 17 1,000 1,841E-03 0,01996824 ! neuromuscular junction development GO:0007528 23 17 1,000 1,841E-03 0,0198745 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 1,841E-03 0,01978162 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 1,841E-03 0,01968962 ! cell-cell junction organization GO:0045216 25 17 1,000 1,841E-03 0,01959846 ! protein oligomerization GO:0051259 100 65 2,000 1,9E-03 0,02013304 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 2,066E-03 0,02179288 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 2,066E-03 0,02169337 ! pigmentation during development GO:0048066 31 18 1,000 2,066E-03 0,02159476 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 2,066E-03 0,02149705 ! somitogenesis GO:0001756 24 18 1,000 2,066E-03 0,02140021 ! cellular response to nutrient levels GO:0031669 27 18 1,000 2,066E-03 0,02130425 ! negative regulation of T cell activation GO:0050868 25 18 1,000 2,066E-03 0,02120914 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 2,066E-03 0,02111488 ! development of primary sexual characteristics GO:0045137 92 68 2,000 2,162E-03 0,02200182 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 2,303E-03 0,02333421 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 2,303E-03 0,02323186 ! response to starvation GO:0042594 30 19 1,000 2,303E-03 0,02313042 ! sex determination GO:0007530 29 19 1,000 2,303E-03 0,02302985 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 2,303E-03 0,02293015 ! protein stabilization GO:0050821 26 19 1,000 2,303E-03 0,02283132 ! chromosome condensation GO:0030261 31 20 1,000 2,553E-03 0,02519787 ! positive regulation of B cell activation GO:0050871 31 20 1,000 2,553E-03 0,02509019 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 2,815E-03 0,02754618 ! protein amino acid acylation GO:0043543 37 21 1,000 2,815E-03 0,02742946 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 2,815E-03 0,02731372 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 2,815E-03 0,02719896 ! negative regulation of growth GO:0045926 123 75 2,000 2,859E-03 0,02751102 ! regulation of protein transport GO:0051223 114 76 2,000 2,968E-03 0,02844594 GO:0070201|regulation of establishment of protein localization, ! gland development GO:0048732 148 77 2,000 3,08E-03 0,02939747 ! sex differentiation GO:0007548 105 77 2,000 3,08E-03 0,029276 ! protein ubiquitination GO:0016567 125 77 2,000 3,08E-03 0,02915552 ! regulation of DNA binding GO:0051101 119 77 2,000 3,08E-03 0,02903603 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 3,088E-03 0,02899344 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 3,088E-03 0,02887559 ! microtubule organizing center organization GO:0031023 28 22 1,000 3,088E-03 0,02875868 GO:0051297|centrosome organization, ! blastocyst development GO:0001824 37 22 1,000 3,088E-03 0,02864272 ! positive regulation of protein modification process GO:0031401 107 78 2,000 3,195E-03 0,02951193 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 3,374E-03 0,03104407 ! myelination GO:0042552 35 23 1,000 3,374E-03 0,03092039 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 3,374E-03 0,03079769 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 3,374E-03 0,03067596 ! negative regulation of catabolic process GO:0009895 34 23 1,000 3,374E-03 0,03055519 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 3,672E-03 0,03312163 ! mitochondrial membrane organization GO:0007006 39 24 1,000 3,672E-03 0,03299224 ! response to toxin GO:0009636 38 24 1,000 3,672E-03 0,03286387 ! negative regulation of cell development GO:0010721 56 24 1,000 3,672E-03 0,03273649 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 3,672E-03 0,0326101 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 3,672E-03 0,03248467 ! regulation of defense response GO:0031347 117 84 2,000 3,938E-03 0,03470182 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 3,982E-03 0,03495486 ! regulation of protein localization GO:0032880 132 85 2,000 4,071E-03 0,03560245 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 4,207E-03 0,03665136 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 4,303E-03 0,03734825 ! regulation of pH GO:0006885 36 26 1,000 4,303E-03 0,03720784 ! skeletal muscle tissue development GO:0007519 123 87 2,000 4,346E-03 0,03743354 GO:0060538|skeletal muscle organ development, ! interphase GO:0051325 159 88 2,000 4,487E-03 0,03850698 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 4,636E-03 0,03963994 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 4,636E-03 0,03949312 GO:0043433|negative regulation of transcription factor activity, ! protein modification by small protein conjugation GO:0032446 140 90 2,000 4,778E-03 0,04055057 ! cell junction assembly GO:0034329 56 28 1,000 4,981E-03 0,04211596 ! response to organic cyclic substance GO:0014070 47 28 1,000 4,981E-03 0,04196169 ! ensheathment of neurons GO:0007272 43 28 1,000 4,981E-03 0,04180855 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 1,000 4,981E-03 0,04165651 ! cell fate commitment GO:0045165 141 92 2,000 5,08E-03 0,04233423 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 5,337E-03 0,04431146 ! tissue homeostasis GO:0001894 42 29 1,000 5,337E-03 0,04415207 GO:0048871|multicellular organismal homeostasis, ! regulation of binding GO:0051098 151 95 2,000 5,555E-03 0,04579072 ! organic anion transport GO:0015711 51 30 1,000 5,704E-03 0,04685407 ! adult locomotory behavior GO:0008344 47 30 1,000 5,704E-03 0,04668733 ! negative regulation of cell activation GO:0050866 44 30 1,000 5,704E-03 0,04652177 ! response to heat GO:0009408 41 30 1,000 5,704E-03 0,04635738 ! regulation of response to external stimulus GO:0032101 139 96 2,000 5,718E-03 0,04631177 ! in utero embryonic development GO:0001701 147 96 2,000 5,718E-03 0,04614927 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 5,718E-03 0,04598791 ! DNA damage checkpoint GO:0000077 53 31 1,000 6,083E-03 0,0487454 ! xenobiotic metabolic process GO:0006805 44 31 1,000 6,083E-03 0,04857615 ! odontogenesis GO:0042476 50 31 1,000 6,083E-03 0,04840807 ! maintenance of protein location in cell GO:0032507 60 31 1,000 6,083E-03 0,04824114 ! segmentation GO:0035282 41 31 1,000 6,083E-03 0,04807536 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 6,083E-03 0,04791072 ! cell fate specification GO:0001708 37 31 1,000 6,083E-03 0,0477472 ! extracellular structure organization GO:0043062 156 99 2,000 6,227E-03 0,04871839 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 6,227E-03 0,04855325 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 6,472E-03 0,05029206 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 6,472E-03 0,05012273 ! peripheral nervous system development GO:0007422 53 32 1,000 6,472E-03 0,04995453 ! regulation of protein stability GO:0031647 48 32 1,000 6,472E-03 0,04978746 ! calcium-mediated signaling GO:0019722 50 32 1,000 6,472E-03 0,0496215 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 6,873E-03 0,05251991 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! sister chromatid segregation GO:0000819 46 33 1,000 6,873E-03 0,05234601 ! cell junction organization GO:0034330 63 33 1,000 6,873E-03 0,05217325 ! carbohydrate homeostasis GO:0033500 39 33 1,000 6,873E-03 0,05200162 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 6,873E-03 0,05183113 ! negative regulation of DNA binding GO:0043392 54 33 1,000 6,873E-03 0,05166174 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 6,873E-03 0,05149347 ! cytokinesis GO:0000910 52 33 1,000 6,873E-03 0,05132628 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 7,285E-03 0,0542261 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 7,285E-03 0,05405118 ! DNA integrity checkpoint GO:0031570 57 34 1,000 7,285E-03 0,05387738 ! female gamete generation GO:0007292 43 34 1,000 7,285E-03 0,05370469 ! regulation of metal ion transport GO:0010959 47 35 1,000 7,708E-03 0,05664014 ! regulation of action potential in neuron GO:0019228 54 35 1,000 7,708E-03 0,05645976 ! maintenance of protein location GO:0045185 65 35 1,000 7,708E-03 0,05628052 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 7,708E-03 0,05610241 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 8,142E-03 0,0590719 GO:0090047|positive regulation of transcription regulator activity, ! negative regulation of binding GO:0051100 58 36 1,000 8,142E-03 0,05888614 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 8,142E-03 0,05870154 GO:0046660|female sex differentiation, ! response to xenobiotic stimulus GO:0009410 50 36 1,000 8,142E-03 0,0585181 ! regulation of T cell proliferation GO:0042129 58 38 1,000 9,041E-03 0,06478087 ! pigmentation GO:0043473 74 38 1,000 9,041E-03 0,06457969 ! maintenance of location in cell GO:0051651 69 38 1,000 9,041E-03 0,06437975 ! male sex differentiation GO:0046661 53 39 1,000 9,507E-03 0,06748675 ! developmental growth GO:0048589 62 39 1,000 9,507E-03 0,0672791 ! cell growth GO:0016049 61 39 1,000 9,507E-03 0,06707272 ! synapse organization GO:0050808 55 39 1,000 9,507E-03 0,06686761 ! response to calcium ion GO:0051592 58 40 1,000 9,983E-03 0,07000277 ! peptide metabolic process GO:0006518 56 40 1,000 9,983E-03 0,06978999 ! T cell differentiation GO:0030217 65 40 1,000 9,983E-03 0,06957851 ! B cell differentiation GO:0030183 62 40 1,000 9,983E-03 0,0693683 ! positive regulation of protein transport GO:0051222 55 40 1,000 9,983E-03 0,06915936 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01046959 0,07231252 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,01046959 0,07209601 ! mitochondrial transport GO:0006839 60 42 1,000 0,01096652 0,07529253 ! receptor-mediated endocytosis GO:0006898 76 42 1,000 0,01096652 0,07506845 ! positive regulation of binding GO:0051099 59 43 1,000 0,0114737 0,07830715 ! neuromuscular process GO:0050905 79 43 1,000 0,0114737 0,07807547 ! activation of caspase activity GO:0006919 65 43 1,000 0,0114737 0,07784516 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,0114737 0,0776162 ! regulation of action potential GO:0001508 71 44 1,000 0,01199105 0,08087804 ! regulation of ion transport GO:0043269 57 44 1,000 0,01199105 0,08064155 ! regulation of translational initiation GO:0006446 64 45 1,000 0,01251848 0,08394319 ! cell maturation GO:0048469 60 45 1,000 0,01251848 0,08369917 ! histone modification GO:0016570 68 46 1,000 0,01305593 0,08703953 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,0136033 0,09042656 ! covalent chromatin modification GO:0016569 75 47 1,000 0,0136033 0,09016596 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,0136033 0,08990687 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,0136033 0,08964925 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,01416052 0,09305483 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 1,000 0,01416052 0,09278971 ! heart morphogenesis GO:0003007 65 48 1,000 0,01416052 0,09252611 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,01416052 0,09226399 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,0147275 0,09568715 ! germ cell development GO:0007281 68 49 1,000 0,0147275 0,09541761 ! maintenance of location GO:0051235 84 49 1,000 0,0147275 0,09514958 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,01530417 0,09859831 ! lipid modification GO:0030258 73 50 1,000 0,01530417 0,09832289 ! positive regulation of growth GO:0045927 67 50 1,000 0,01530417 0,09804901 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,01589045 0,10152233 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,01589045 0,1012411 ! adult behavior GO:0030534 80 51 1,000 0,01589045 0,10096143 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01648626 0,1044584 ! cell projection assembly GO:0030031 76 53 1,000 0,01709152 0,10799588 ! amino acid transport GO:0006865 84 54 1,000 0,01770616 0,11157305 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,01770616 0,11126821 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,01770616 0,11096502 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,01770616 0,11066349 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01873669 0,11678698 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01873669 0,11647134 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01873669 0,1161574 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01873669 0,11584515 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01873669 0,11553457 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01873669 0,11522566 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01873669 0,11491839 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01873669 0,11461275 ! sleep GO:0030431 11 5 0,000 0,01873669 0,11430874 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01873669 0,11400634 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01873669 0,11370553 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01873669 0,1134063 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01873669 0,11310865 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01873669 0,11281255 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01873669 0,112518 ! tongue development GO:0043586 6 5 0,000 0,01873669 0,11222499 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01873669 0,11193349 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01873669 0,11164351 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01873669 0,11135503 ! cobalt ion transport GO:0006824 9 5 0,000 0,01873669 0,11106803 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01873669 0,11078251 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01873669 0,11049845 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01873669 0,11021584 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01873669 0,10993468 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01873669 0,10965495 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01873669 0,10937664 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01873669 0,10909973 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01873669 0,10882423 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01873669 0,10855011 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01873669 0,10827737 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01873669 0,108006 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01873669 0,10773599 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01873669 0,10746732 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01873669 0,10719999 ! malate metabolic process GO:0006108 7 5 0,000 0,01873669 0,10693398 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01873669 0,10666929 ! behavioral response to pain GO:0048266 7 5 0,000 0,01873669 0,10640591 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01873669 0,10614383 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01873669 0,10588303 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01873669 0,10562352 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01873669 0,10536527 ! mating behavior GO:0007617 6 5 0,000 0,01873669 0,10510828 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01873669 0,10485254 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01873669 0,10459805 ! rhythmic behavior GO:0007622 12 5 0,000 0,01873669 0,10434478 ! copulation GO:0007620 7 5 0,000 0,01873669 0,10409274 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01873669 0,10384192 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01873669 0,1035923 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01873669 0,10334387 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01873669 0,10309664 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01873669 0,10285058 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01873669 0,1026057 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01873669 0,10236198 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01873669 0,10211942 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01873669 0,101878 ! response to protozoan GO:0001562 9 5 0,000 0,01873669 0,10163772 ! lymph vessel development GO:0001945 7 5 0,000 0,01873669 0,10139858 ! endochondral ossification GO:0001958 12 5 0,000 0,01873669 0,10116055 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01873669 0,10092364 ! parathyroid gland development GO:0060017 8 5 0,000 0,01873669 0,10068784 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01873669 0,10045314 ! anagen GO:0042640 6 5 0,000 0,01873669 0,10021952 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01873669 0,099987 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01873669 0,09975554 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01873669 0,09952516 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01873669 0,09929584 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01873669 0,09906757 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01873669 0,09884036 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01873669 0,09861418 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01873669 0,09838903 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01873669 0,09816491 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01873669 0,09794181 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01873669 0,09771972 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01873669 0,09749863 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01873669 0,09727854 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01873669 0,09705945 ! ovulation GO:0030728 6 5 0,000 0,01873669 0,09684134 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01873669 0,0966242 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,01873669 0,09640804 ! response to pH GO:0009268 9 5 0,000 0,01873669 0,09619285 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01873669 0,09597861 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01873669 0,09576532 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01873669 0,09555298 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01873669 0,09534158 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01873669 0,09513111 ! polyol catabolic process GO:0046174 7 5 0,000 0,01873669 0,09492158 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01873669 0,09471296 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01873669 0,09450525 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01873669 0,09429846 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01873669 0,09409257 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01873669 0,09388757 ! urea metabolic process GO:0019627 6 5 0,000 0,01873669 0,09368347 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01873669 0,09348025 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01873669 0,09327791 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01873669 0,09307645 ! neutrophil activation GO:0042119 5 5 0,000 0,01873669 0,09287585 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01873669 0,09267612 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01873669 0,09247724 ! response to food GO:0032094 5 5 0,000 0,01873669 0,09227922 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01873669 0,09208204 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01873669 0,0918857 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01873669 0,0916902 ! forebrain neuron development GO:0021884 7 5 0,000 0,01873669 0,09149553 ! melanosome organization GO:0032438 7 5 0,000 0,01873669 0,09130168 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01873669 0,09110866 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01873669 0,09091645 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01873669 0,09072504 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01873669 0,09053444 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01873669 0,09034464 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01873669 0,09015564 ! nucleoside transport GO:0015858 6 5 0,000 0,01873669 0,08996742 ! nucleoside salvage GO:0043174 7 5 0,000 0,01873669 0,08977999 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01873669 0,08959334 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01873669 0,08940746 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01873669 0,08922235 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01873669 0,08903801 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01873669 0,08885442 ! depyrimidination GO:0045008 8 5 0,000 0,01873669 0,08867159 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01873669 0,08848952 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01873669 0,08830819 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01873669 0,0881276 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01873669 0,08794775 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01873669 0,08776863 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01873669 0,08759023 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01873669 0,08741257 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01873669 0,08723562 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01873669 0,08705938 ! monocyte differentiation GO:0030224 8 5 0,000 0,01873669 0,08688386 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01873669 0,08670904 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01873669 0,08653493 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01873669 0,08636151 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01873669 0,08618879 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01873669 0,08601676 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01873669 0,08584541 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01873669 0,08567474 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01873669 0,08550475 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01873669 0,08533544 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01873669 0,08516679 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01873669 0,08499881 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01873669 0,08483149 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01873669 0,08466482 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01873669 0,08449881 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01873669 0,08433345 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01873669 0,08416874 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01873669 0,08400467 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01873669 0,08384124 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01873669 0,08367844 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01873669 0,08351627 ! neural tube patterning GO:0021532 6 5 0,000 0,01873669 0,08335473 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01873669 0,08319381 ! histone demethylation GO:0016577 9 5 0,000 0,01873669 0,08303352 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01873669 0,08287384 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01873669 0,08271477 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01873669 0,08255631 ! enteric nervous system development GO:0048484 8 5 0,000 0,01873669 0,08239846 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01873669 0,08224121 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01873669 0,08208456 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01873669 0,08192851 ! transcription termination GO:0006353 8 5 0,000 0,01873669 0,08177305 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01873669 0,08161817 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01873669 0,08146388 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01873669 0,08131018 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01873669 0,08115705 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01873669 0,0810045 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01873669 0,08085252 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01873669 0,08070111 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01873669 0,08055027 ! apical protein localization GO:0045176 6 5 0,000 0,01873669 0,08039999 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01873669 0,08025027 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01873669 0,08010111 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01873669 0,0799525 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01873669 0,07980444 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01873669 0,07965692 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01873669 0,07950995 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01873669 0,07936353 ! glial cell migration GO:0008347 10 5 0,000 0,01873669 0,07921764 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01873669 0,07907228 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01873669 0,07892746 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01873669 0,07878317 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01873669 0,07863941 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01873669 0,07849617 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01873669 0,07835345 ! neural plate development GO:0001840 6 5 0,000 0,01873669 0,07821124 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01873669 0,07806956 ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01873669 0,07792838 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01873669 0,07778772 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01873669 0,07764756 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01873669 0,0775079 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01873669 0,07736875 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01873669 0,0772301 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01873669 0,07709194 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01873669 0,07695428 ! spindle assembly GO:0051225 5 5 0,000 0,01873669 0,0768171 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01873669 0,07668042 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01873669 0,07654422 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01873669 0,0764085 ! organ regeneration GO:0031100 7 5 0,000 0,01873669 0,07627327 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01873669 0,07613851 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01873669 0,07600422 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01873669 0,07587041 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01873669 0,07573707 GO:0055081|anion homeostasis, ! chromosome segregation GO:0007059 83 57 1,000 0,01960554 0,07911008 ! developmental maturation GO:0021700 75 57 1,000 0,01960554 0,07897154 ! gonad development GO:0008406 79 57 1,000 0,01960554 0,07883347 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,02025691 0,08131045 ! activation of MAPK activity GO:0000187 84 59 1,000 0,02091727 0,08381484 ! actin filament organization GO:0007015 95 59 1,000 0,02091727 0,08366907 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,02158654 0,08619627 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,02158654 0,08604689 ! meiosis GO:0007126 96 61 1,000 0,02226467 0,08859642 GO:0051327|M phase of meiotic cell cycle, ! extracellular matrix organization GO:0030198 103 61 1,000 0,02226467 0,0884434 ! tRNA transcription GO:0009304 11 6 0,000 0,02244233 0,08899544 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02244233 0,08884226 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02244233 0,08868961 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02244233 0,08853749 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02244233 0,08838588 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02244233 0,08823479 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02244233 0,08808422 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02244233 0,08793417 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02244233 0,08778462 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02244233 0,08763558 ! prostate gland development GO:0030850 9 6 0,000 0,02244233 0,08748704 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02244233 0,08733901 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02244233 0,08719148 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02244233 0,08704444 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02244233 0,0868979 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02244233 0,08675186 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02244233 0,0866063 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02244233 0,08646123 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02244233 0,08631665 ! neuron adhesion GO:0007158 9 6 0,000 0,02244233 0,08617255 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02244233 0,08602892 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02244233 0,08588578 ! signal peptide processing GO:0006465 8 6 0,000 0,02244233 0,08574311 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02244233 0,08560092 ! mRNA stabilization GO:0048255 15 6 0,000 0,02244233 0,0854592 GO:0043489|RNA stabilization, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02244233 0,08531794 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02244233 0,08517715 ! opsonization GO:0008228 8 6 0,000 0,02244233 0,08503683 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02244233 0,08489697 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02244233 0,08475756 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02244233 0,08461861 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02244233 0,08448012 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02244233 0,08434208 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02244233 0,08420449 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02244233 0,08406735 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02244233 0,08393066 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02244233 0,08379441 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02244233 0,0836586 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02244233 0,08352323 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02244233 0,0833883 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02244233 0,0832538 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02244233 0,08311973 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02244233 0,0829861 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02244233 0,0828529 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02244233 0,08272012 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02244233 0,08258777 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02244233 0,08245584 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02244233 0,08232433 ! thymic T cell selection GO:0045061 12 6 0,000 0,02244233 0,08219324 ! protein lipoylation GO:0009249 10 6 0,000 0,02244233 0,08206257 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02244233 0,08193231 ! pigment granule organization GO:0048753 11 6 0,000 0,02244233 0,08180246 ! drug transport GO:0015893 6 6 0,000 0,02244233 0,08167303 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02244233 0,081544 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02244233 0,08141539 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02244233 0,08128717 ! histidine metabolic process GO:0006547 6 6 0,000 0,02244233 0,08115936 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02244233 0,08103195 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02244233 0,08090495 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02244233 0,08077833 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02244233 0,08065212 ! adenohypophysis development GO:0021984 10 6 0,000 0,02244233 0,08052629 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02244233 0,08040086 ! hyperosmotic response GO:0006972 8 6 0,000 0,02244233 0,08027582 ! microtubule nucleation GO:0007020 10 6 0,000 0,02244233 0,08015117 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02244233 0,08002691 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02244233 0,07990303 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02244233 0,07977953 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02244233 0,07965641 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02244233 0,07953367 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02244233 0,07941132 ! response to dietary excess GO:0002021 7 6 0,000 0,02244233 0,07928933 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02244233 0,07916772 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02244233 0,07904649 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02244233 0,07892562 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02244233 0,07880512 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02244233 0,07868499 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02244233 0,07856523 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02244233 0,07844583 ! neuron apoptosis GO:0051402 8 6 0,000 0,02244233 0,07832679 ! organic alcohol transport GO:0015850 9 6 0,000 0,02244233 0,07820811 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02244233 0,0780898 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02244233 0,07797184 ! carnitine transport GO:0015879 8 6 0,000 0,02244233 0,07785423 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02244233 0,07773698 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02244233 0,07762008 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02244233 0,07750354 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02244233 0,07738734 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02244233 0,07727149 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02244233 0,07715599 ! parturition GO:0007567 12 6 0,000 0,02244233 0,07704083 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02244233 0,07692601 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02244233 0,07681154 ! spindle checkpoint GO:0031577 14 6 0,000 0,02244233 0,07669741 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02244233 0,07658361 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02244233 0,07647016 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02244233 0,07635703 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02244233 0,07624425 ! macrophage differentiation GO:0030225 10 6 0,000 0,02244233 0,07613179 ! astrocyte development GO:0014002 14 6 0,000 0,02244233 0,07601967 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02244233 0,07590787 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02244233 0,07579641 ! interaction with symbiont GO:0051702 8 6 0,000 0,02244233 0,07568527 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02244233 0,07557446 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02244233 0,07546397 ! eating behavior GO:0042755 6 6 0,000 0,02244233 0,0753538 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02244233 0,07524396 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02244233 0,07513443 ! response to copper ion GO:0046688 9 6 0,000 0,02244233 0,07502523 ! DNA topological change GO:0006265 8 6 0,000 0,02244233 0,07491634 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02244233 0,07480776 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02244233 0,0746995 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02244233 0,07459155 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02244233 0,07448392 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02244233 0,07437659 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02244233 0,07426958 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02244233 0,07416287 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02244233 0,07405646 ! gas homeostasis GO:0033483 11 6 0,000 0,02244233 0,07395037 ! hair follicle maturation GO:0048820 7 6 0,000 0,02244233 0,07384457 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02244233 0,07373908 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02244233 0,07363389 ! Schwann cell development GO:0014044 14 6 0,000 0,02244233 0,073529 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02244233 0,0734244 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02244233 0,07332011 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02244233 0,07321611 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02244233 0,0731124 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02244233 0,07300899 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02244233 0,07290587 ! histone ubiquitination GO:0016574 7 6 0,000 0,02244233 0,07280304 ! regulation of meiosis GO:0040020 10 6 0,000 0,02244233 0,0727005 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02244233 0,07259825 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02244233 0,07249629 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02244233 0,07239461 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02244233 0,07229321 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02244233 0,0721921 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02244233 0,07209128 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02244233 0,07199073 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02244233 0,07189047 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02244233 0,07179048 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02244233 0,07169077 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02244233 0,07159134 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02244233 0,07149218 ! protein deubiquitination GO:0016579 8 6 0,000 0,02244233 0,0713933 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02244233 0,07129469 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02244233 0,07119635 ! axonal fasciculation GO:0007413 9 6 0,000 0,02244233 0,07109829 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02244233 0,07100049 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02244233 0,07090296 ! midbrain development GO:0030901 6 6 0,000 0,02244233 0,0708057 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02244233 0,07070871 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02244233 0,07061198 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02244233 0,07051551 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02244233 0,07041931 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02244233 0,07032337 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02244233 0,07022769 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02244233 0,07013228 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02244233 0,07003712 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02244233 0,06994222 ! adult feeding behavior GO:0008343 6 6 0,000 0,02244233 0,06984757 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02244233 0,06975318 ! pigment granule transport GO:0051904 12 6 0,000 0,02244233 0,06965905 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02244233 0,06956517 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02244233 0,06947154 ! catecholamine transport GO:0051937 7 6 0,000 0,02244233 0,06937817 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02244233 0,06928504 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02244233 0,06919216 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02244233 0,06909954 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02244233 0,06900716 ! protein prenylation GO:0018342 10 6 0,000 0,02244233 0,06891503 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02244233 0,06882314 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02244233 0,0687315 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02244233 0,0686401 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02244233 0,06854894 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02244233 0,06845803 ! meiotic cell cycle GO:0051321 97 62 1,000 0,02295155 0,06991864 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,02364714 0,07194236 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,02364714 0,07184732 ! regulation of lipase activity GO:0060191 109 63 1,000 0,02364714 0,07175254 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,02435135 0,07379196 ! reproductive structure development GO:0048608 90 65 1,000 0,0250641 0,0758519 ! regulation of caspase activity GO:0043281 97 65 1,000 0,0250641 0,07575222 ! B cell activation GO:0042113 104 65 1,000 0,0250641 0,07565281 ! axon guidance GO:0007411 99 66 1,000 0,02578534 0,07772776 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02613418 0,0786762 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02613418 0,07857335 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02613418 0,07847078 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02613418 0,07836847 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02613418 0,07826643 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02613418 0,07816465 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02613418 0,07806314 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02613418 0,07796189 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02613418 0,0778609 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02613418 0,07776017 ! reproductive behavior GO:0019098 12 7 0,000 0,02613418 0,07765971 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02613418 0,0775595 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,02613418 0,07745955 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02613418 0,07735986 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,02613418 0,07726043 ! oligopeptide transport GO:0006857 11 7 0,000 0,02613418 0,07716125 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02613418 0,07706233 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02613418 0,07696366 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02613418 0,07686524 ! RNA methylation GO:0001510 11 7 0,000 0,02613418 0,07676707 ! pericardium development GO:0060039 8 7 0,000 0,02613418 0,07666915 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02613418 0,07657148 ! fibril organization GO:0043206 13 7 0,000 0,02613418 0,07647406 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02613418 0,07637689 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02613418 0,07627997 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02613418 0,07618329 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02613418 0,07608685 ! lipoprotein transport GO:0042953 9 7 0,000 0,02613418 0,07599066 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02613418 0,07589472 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02613418 0,07579901 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02613418 0,07570354 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02613418 0,07560832 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02613418 0,07551334 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02613418 0,07541859 ! chemosensory behavior GO:0007635 9 7 0,000 0,02613418 0,07532408 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02613418 0,07522981 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02613418 0,07513577 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02613418 0,07504197 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02613418 0,0749484 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02613418 0,07485506 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02613418 0,07476196 ! reflex GO:0060004 12 7 0,000 0,02613418 0,07466909 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02613418 0,07457645 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02613418 0,07448403 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02613418 0,07439185 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02613418 0,07429989 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02613418 0,07420817 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02613418 0,07411666 ! spinal cord patterning GO:0021511 7 7 0,000 0,02613418 0,07402539 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02613418 0,07393434 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02613418 0,07384351 ! adrenal gland development GO:0030325 17 7 0,000 0,02613418 0,0737529 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02613418 0,07366252 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02613418 0,07357236 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02613418 0,07348241 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02613418 0,07339269 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02613418 0,07330319 ! endosome organization GO:0007032 10 7 0,000 0,02613418 0,0732139 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02613418 0,07312484 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02613418 0,07303598 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02613418 0,07294735 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02613418 0,07285893 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02613418 0,07277072 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02613418 0,07268273 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02613418 0,07259495 ! galactose metabolic process GO:0006012 10 7 0,000 0,02613418 0,07250738 ! vesicle fusion GO:0006906 15 7 0,000 0,02613418 0,07242002 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02613418 0,07233287 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02613418 0,07224593 ! organ growth GO:0035265 11 7 0,000 0,02613418 0,0721592 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02613418 0,07207268 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02613418 0,07198636 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02613418 0,07190026 ! retinol metabolic process GO:0042572 9 7 0,000 0,02613418 0,07181435 ! behavioral fear response GO:0001662 13 7 0,000 0,02613418 0,07172866 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02613418 0,07164316 ! rRNA modification GO:0000154 12 7 0,000 0,02613418 0,07155787 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02613418 0,07147279 ! response to UV-B GO:0010224 11 7 0,000 0,02613418 0,0713879 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02613418 0,07130322 ! intermediate filament organization GO:0045109 11 7 0,000 0,02613418 0,07121874 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02613418 0,07113446 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02613418 0,07105037 ! fibrinolysis GO:0042730 9 7 0,000 0,02613418 0,07096649 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02613418 0,0708828 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02613418 0,07079931 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02613418 0,07071602 ! response to tropane GO:0014073 13 7 0,000 0,02613418 0,07063292 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02613418 0,07055002 ! melanosome localization GO:0032400 10 7 0,000 0,02613418 0,07046731 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02613418 0,07038479 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02613418 0,07030247 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02613418 0,07022034 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02613418 0,07013841 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02613418 0,07005666 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02613418 0,0699751 ! mast cell activation GO:0045576 9 7 0,000 0,02613418 0,06989374 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02613418 0,06981256 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02613418 0,06973157 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02613418 0,06965077 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02613418 0,06957016 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02613418 0,06948973 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02613418 0,06940949 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,02613418 0,06932943 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02613418 0,06924956 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02613418 0,06916987 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02613418 0,06909036 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02613418 0,06901104 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02613418 0,0689319 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02613418 0,06885294 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02613418 0,06877416 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02613418 0,06869556 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02613418 0,06861714 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02613418 0,0685389 ! diuresis GO:0030146 12 7 0,000 0,02613418 0,06846084 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02613418 0,06838295 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02613418 0,06830524 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02613418 0,06822771 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02613418 0,06815036 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02613418 0,06807318 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02613418 0,06799617 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02613418 0,06791934 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02613418 0,06784268 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02613418 0,06776619 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02613418 0,06768988 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02613418 0,06761374 ! lymph node development GO:0048535 9 7 0,000 0,02613418 0,06753777 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02613418 0,06746197 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02613418 0,06738634 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02613418 0,06731088 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02613418 0,06723559 ! ATP catabolic process GO:0006200 10 7 0,000 0,02613418 0,06716046 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02613418 0,06708551 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02613418 0,06701072 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02613418 0,0669361 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02613418 0,06686164 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02613418 0,06678735 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02613418 0,06671322 ! muscle adaptation GO:0043500 12 7 0,000 0,02613418 0,06663926 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02613418 0,06656546 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02613418 0,06649183 ! retina homeostasis GO:0001895 9 7 0,000 0,02613418 0,06641836 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02613418 0,06634505 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02613418 0,0662719 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02613418 0,06619891 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02613418 0,06612609 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02613418 0,06605342 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02613418 0,06598092 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02613418 0,06590857 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,02651498 0,06679567 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,02725295 0,06857963 ! response to drug GO:0042493 108 69 1,000 0,02799918 0,07038046 ! response to metal ion GO:0010038 103 70 1,000 0,02875361 0,07219792 ! amine transport GO:0015837 101 70 1,000 0,02875361 0,07211918 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,02951615 0,07395114 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,02951615 0,07387067 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0298123 0,07453075 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0298123 0,07444983 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0298123 0,07436908 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0298123 0,07428851 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0298123 0,07420811 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,0298123 0,07412788 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,0298123 0,07404783 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0298123 0,07396795 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0298123 0,07388824 ! phosphate transport GO:0006817 10 8 0,000 0,0298123 0,07380871 ! N-glycan processing GO:0006491 12 8 0,000 0,0298123 0,07372934 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0298123 0,07365015 ! UTP metabolic process GO:0046051 8 8 0,000 0,0298123 0,07357113 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0298123 0,07349227 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0298123 0,07341359 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0298123 0,07333507 ! succinate metabolic process GO:0006105 14 8 0,000 0,0298123 0,07325672 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,0298123 0,07317854 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,0298123 0,07310052 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0298123 0,07302267 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,0298123 0,07294499 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0298123 0,07286747 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,0298123 0,07279012 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0298123 0,07271293 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0298123 0,0726359 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0298123 0,07255904 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0298123 0,07248234 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,0298123 0,0724058 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0298123 0,07232942 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0298123 0,0722532 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0298123 0,07217715 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0298123 0,07210125 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0298123 0,07202552 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0298123 0,07194994 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0298123 0,07187452 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0298123 0,07179926 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0298123 0,07172415 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0298123 0,07164921 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0298123 0,07157442 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0298123 0,07149978 ! melanin metabolic process GO:0006582 12 8 0,000 0,0298123 0,0714253 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0298123 0,07135098 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0298123 0,07127681 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,0298123 0,07120279 ! macrophage activation GO:0042116 12 8 0,000 0,0298123 0,07112893 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0298123 0,07105522 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0298123 0,07098167 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0298123 0,07090826 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,0298123 0,07083501 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0298123 0,07076191 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0298123 0,07068896 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0298123 0,07061616 ! ruffle organization GO:0031529 11 8 0,000 0,0298123 0,07054351 ! osteoblast development GO:0002076 13 8 0,000 0,0298123 0,07047101 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0298123 0,07039866 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0298123 0,07032645 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0298123 0,0702544 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0298123 0,07018249 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,0298123 0,07011073 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0298123 0,07003911 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0298123 0,06996764 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0298123 0,06989632 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0298123 0,06982514 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,0298123 0,06975411 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,0298123 0,06968322 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0298123 0,06961248 ! segment specification GO:0007379 10 8 0,000 0,0298123 0,06954188 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0298123 0,06947142 ! cellular extravasation GO:0045123 11 8 0,000 0,0298123 0,0694011 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0298123 0,06933093 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0298123 0,0692609 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0298123 0,06919101 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0298123 0,06912126 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0298123 0,06905165 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0298123 0,06898218 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0298123 0,06891285 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,0298123 0,06884366 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0298123 0,06877461 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0298123 0,0687057 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0298123 0,06863693 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0298123 0,06856829 ! icosanoid secretion GO:0032309 12 8 0,000 0,0298123 0,06849979 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0298123 0,06843143 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0298123 0,0683632 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0298123 0,06829511 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0298123 0,06822715 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,0298123 0,06815933 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0298123 0,06809165 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0298123 0,0680241 ! sterol catabolic process GO:0016127 9 8 0,000 0,0298123 0,06795668 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0298123 0,0678894 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0298123 0,06782225 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0298123 0,06775523 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0298123 0,06768834 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0298123 0,06762159 ! prophase GO:0051324 11 8 0,000 0,0298123 0,06755497 ! S phase GO:0051320 8 8 0,000 0,0298123 0,06748847 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0298123 0,06742211 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0298123 0,06735588 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0298123 0,06728978 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0298123 0,06722381 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0298123 0,06715797 ! hormone catabolic process GO:0042447 13 8 0,000 0,0298123 0,06709226 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0298123 0,06702668 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,0298123 0,06696122 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0298123 0,06689589 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0298123 0,06683069 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0298123 0,06676562 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,0298123 0,06670067 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0298123 0,06663585 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0298123 0,06657116 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,0298123 0,06650659 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0298123 0,06644214 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0298123 0,06637782 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0298123 0,06631363 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0298123 0,06624956 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0298123 0,06618561 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,0298123 0,06612178 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,03028675 0,06710936 ! response to hypoxia GO:0001666 132 72 1,000 0,03028675 0,06704477 ! mitochondrion organization GO:0007005 104 73 1,000 0,03106532 0,06870215 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,03106532 0,06863616 ! response to oxygen levels GO:0070482 137 74 1,000 0,03185181 0,0703063 ! protein import into nucleus GO:0006606 118 74 1,000 0,03185181 0,07023889 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,03185181 0,07017161 ! response to inorganic substance GO:0010035 115 75 1,000 0,03264614 0,07185275 ! response to nutrient GO:0007584 104 75 1,000 0,03264614 0,07178405 ! nuclear import GO:0051170 121 75 1,000 0,03264614 0,07171549 ! response to unfolded protein GO:0006986 99 76 1,000 0,03344824 0,07340741 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,03347674 0,0733999 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03347674 0,07333 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03347674 0,07326023 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03347674 0,07319059 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03347674 0,07312108 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,03347674 0,07305171 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,03347674 0,07298246 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03347674 0,07291335 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,03347674 0,07284437 ! GTP metabolic process GO:0046039 9 9 0,000 0,03347674 0,07277552 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03347674 0,0727068 ! social behavior GO:0035176 14 9 0,000 0,03347674 0,07263821 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03347674 0,07256974 ! artery development GO:0060840 19 9 0,000 0,03347674 0,07250141 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03347674 0,07243321 ! response to pain GO:0048265 16 9 0,000 0,03347674 0,07236513 ! protein complex disassembly GO:0043241 17 9 0,000 0,03347674 0,07229718 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03347674 0,07222936 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03347674 0,07216167 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03347674 0,0720941 ! lung alveolus development GO:0048286 17 9 0,000 0,03347674 0,07202666 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03347674 0,07195934 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03347674 0,07189215 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03347674 0,07182509 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03347674 0,07175815 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03347674 0,07169134 ! protein targeting to ER GO:0045047 19 9 0,000 0,03347674 0,07162465 ! T cell selection GO:0045058 18 9 0,000 0,03347674 0,07155808 ! endoderm development GO:0007492 12 9 0,000 0,03347674 0,07149164 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03347674 0,07142532 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03347674 0,07135913 ! arginine catabolic process GO:0006527 10 9 0,000 0,03347674 0,07129305 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03347674 0,0712271 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03347674 0,07116127 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,03347674 0,07109557 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,03347674 0,07102998 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,03347674 0,07096451 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03347674 0,07089917 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03347674 0,07083394 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03347674 0,07076884 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03347674 0,07070385 ! mannose metabolic process GO:0006013 9 9 0,000 0,03347674 0,07063899 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,03347674 0,07057424 ! epithelial cell development GO:0002064 10 9 0,000 0,03347674 0,07050961 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03347674 0,0704451 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03347674 0,07038071 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03347674 0,07031644 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03347674 0,07025228 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03347674 0,07018824 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03347674 0,07012431 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03347674 0,07006051 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03347674 0,06999682 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03347674 0,06993324 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03347674 0,06986978 ! DNA ligation GO:0006266 14 9 0,000 0,03347674 0,06980643 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03347674 0,0697432 ! response to amine stimulus GO:0014075 13 9 0,000 0,03347674 0,06968009 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03347674 0,06961709 ! erythrocyte development GO:0048821 11 9 0,000 0,03347674 0,0695542 ! renal water homeostasis GO:0003091 14 9 0,000 0,03347674 0,06949142 ! postreplication repair GO:0006301 11 9 0,000 0,03347674 0,06942876 ! mRNA cleavage GO:0006379 13 9 0,000 0,03347674 0,06936621 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03347674 0,06930378 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,03347674 0,06924145 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03347674 0,06917924 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03347674 0,06911714 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03347674 0,06905515 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03347674 0,06899328 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,03347674 0,06893151 ! acid secretion GO:0046717 14 9 0,000 0,03347674 0,06886985 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03347674 0,06880831 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03347674 0,06874687 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03347674 0,06868555 ! purine base metabolic process GO:0006144 18 9 0,000 0,03347674 0,06862433 ! thymus development GO:0048538 15 9 0,000 0,03347674 0,06856322 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03347674 0,06850222 ! spleen development GO:0048536 15 9 0,000 0,03347674 0,06844133 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03347674 0,06838055 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03347674 0,06831987 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03347674 0,06825931 ! detection of calcium ion GO:0005513 13 9 0,000 0,03347674 0,06819885 ! blastocyst formation GO:0001825 12 9 0,000 0,03347674 0,06813849 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,03347674 0,06807825 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03347674 0,06801811 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,03347674 0,06795807 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03347674 0,06789815 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03347674 0,06783832 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03347674 0,06777861 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03347674 0,067719 ! prepulse inhibition GO:0060134 14 9 0,000 0,03347674 0,06765949 ! embryonic placenta development GO:0001892 12 9 0,000 0,03347674 0,06760009 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,03347674 0,06754079 ! insulin secretion GO:0030073 17 9 0,000 0,03347674 0,06748159 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03347674 0,0674225 ! response to nicotine GO:0035094 16 9 0,000 0,03347674 0,06736351 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03347674 0,06730463 ! nucleus localization GO:0051647 15 9 0,000 0,03347674 0,06724585 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03347674 0,06718717 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,03425805 0,06869531 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,0350755 0,07027322 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,03590052 0,07186354 ! T cell activation GO:0042110 134 79 1,000 0,03590052 0,07180105 ! regulation of lyase activity GO:0051339 133 79 1,000 0,03590052 0,07173867 ! protein localization in nucleus GO:0034504 133 80 1,000 0,03673305 0,07333855 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,03712754 0,07406188 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,03712754 0,07399771 ! neuron fate specification GO:0048665 11 10 0,000 0,03712754 0,07393364 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,03712754 0,07386968 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,03712754 0,07380584 ! thyroid gland development GO:0030878 19 10 0,000 0,03712754 0,0737421 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,03712754 0,07367847 ! synapsis GO:0007129 13 10 0,000 0,03712754 0,07361496 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,03712754 0,07355155 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,03712754 0,07348825 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,03712754 0,07342507 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,03712754 0,07336199 ! sulfate transport GO:0008272 12 10 0,000 0,03712754 0,07329901 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,03712754 0,07323615 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,03712754 0,07317339 ! androgen metabolic process GO:0008209 13 10 0,000 0,03712754 0,07311075 ! phospholipid efflux GO:0033700 16 10 0,000 0,03712754 0,0730482 ! hippocampus development GO:0021766 19 10 0,000 0,03712754 0,07298577 ! blood vessel remodeling GO:0001974 21 10 0,000 0,03712754 0,07292344 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,03712754 0,07286122 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,03712754 0,07279911 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,03712754 0,0727371 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,03712754 0,07267519 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,03712754 0,07261339 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03712754 0,0725517 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,03712754 0,07249011 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,03712754 0,07242863 ! melanocyte differentiation GO:0030318 15 10 0,000 0,03712754 0,07236725 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,03712754 0,07230597 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,03712754 0,0722448 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03712754 0,07218373 ! B cell proliferation GO:0042100 14 10 0,000 0,03712754 0,07212276 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,03712754 0,0720619 ! forebrain cell migration GO:0021885 17 10 0,000 0,03712754 0,07200114 ! lipid digestion GO:0044241 15 10 0,000 0,03712754 0,07194048 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,03712754 0,07187993 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,03712754 0,07181947 ! UV protection GO:0009650 14 10 0,000 0,03712754 0,07175912 ! entry into host cell GO:0030260 20 10 0,000 0,03712754 0,07169887 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,03712754 0,07163872 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,03712754 0,07157867 ! negative regulation of ossification GO:0030279 19 10 0,000 0,03712754 0,07151872 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,03712754 0,07145887 ! regulation of bone resorption GO:0045124 24 10 0,000 0,03712754 0,07139912 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,03712754 0,07133948 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,03712754 0,07127993 ! regulation of organ growth GO:0046620 11 10 0,000 0,03712754 0,07122048 ! response to dsRNA GO:0043331 18 10 0,000 0,03712754 0,07116113 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,03712754 0,07110187 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03712754 0,07104272 ! embryonic axis specification GO:0000578 12 10 0,000 0,03712754 0,07098367 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,03712754 0,07092471 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,03712754 0,07086585 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,03712754 0,07080709 ! cranial nerve development GO:0021545 12 10 0,000 0,03712754 0,07074843 ! fucose catabolic process GO:0019317 16 10 0,000 0,03712754 0,07068986 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,03712754 0,07063139 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,03712754 0,07057302 ! protein sumoylation GO:0016925 12 10 0,000 0,03712754 0,07051474 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,03712754 0,07045656 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03712754 0,07039848 ! zymogen activation GO:0031638 14 10 0,000 0,03712754 0,07034049 ! salivary gland development GO:0007431 22 10 0,000 0,03712754 0,07028259 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03712754 0,0702248 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,03712754 0,07016709 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,03712754 0,07010948 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,03712754 0,07005197 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,03712754 0,06999455 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,03712754 0,06993722 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03712754 0,06987999 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,03712754 0,06982285 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,03712754 0,06976581 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,03712754 0,06970886 ! detection of bacterium GO:0016045 10 10 0,000 0,03712754 0,069652 ! embryonic gut development GO:0048566 11 10 0,000 0,03712754 0,06959523 ! activation of innate immune response GO:0002218 10 10 0,000 0,03712754 0,06953856 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,03712754 0,06948198 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,03712754 0,06942549 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,03712754 0,06936909 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,03712754 0,06931279 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,03712754 0,06925657 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,03757301 0,07003073 ! mRNA transport GO:0051028 121 81 1,000 0,03757301 0,06997403 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,03757301 0,06991741 ! response to protein stimulus GO:0051789 111 81 1,000 0,03757301 0,06986089 ! regulation of neurological system process GO:0031644 122 81 1,000 0,03757301 0,06980446 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,03757301 0,06974812 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,03842034 0,07126354 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,03927498 0,07279006 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,03927498 0,07273145 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,04013686 0,07426773 ! rRNA transcription GO:0009303 17 11 0,000 0,04076477 0,07536894 ! respiratory burst GO:0045730 14 11 0,000 0,04076477 0,07530841 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04076477 0,07524797 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04076477 0,07518762 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04076477 0,07512738 ! filopodium assembly GO:0046847 19 11 0,000 0,04076477 0,07506723 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04076477 0,07500717 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04076477 0,07494722 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,04076477 0,07488735 ! mating GO:0007618 14 11 0,000 0,04076477 0,07482759 ! T cell proliferation GO:0042098 20 11 0,000 0,04076477 0,07476792 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04076477 0,07470834 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,04076477 0,07464886 ! bone resorption GO:0045453 16 11 0,000 0,04076477 0,07458947 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04076477 0,07453018 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04076477 0,07447098 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04076477 0,07441188 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04076477 0,07435287 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04076477 0,07429395 ! syncytium formation GO:0006949 15 11 0,000 0,04076477 0,07423513 ! plasma membrane organization GO:0007009 18 11 0,000 0,04076477 0,0741764 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04076477 0,07411776 ! focal adhesion formation GO:0048041 24 11 0,000 0,04076477 0,07405922 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04076477 0,07400076 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04076477 0,0739424 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04076477 0,07388414 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04076477 0,07382596 ! adult heart development GO:0007512 11 11 0,000 0,04076477 0,07376787 ! temperature homeostasis GO:0001659 16 11 0,000 0,04076477 0,07370988 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04076477 0,07365198 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04076477 0,07359417 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04076477 0,07353644 ! stem cell development GO:0048864 29 11 0,000 0,04076477 0,07347881 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04076477 0,07342127 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04076477 0,07336382 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04076477 0,07330646 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04076477 0,07324919 ! vasoconstriction GO:0042310 15 11 0,000 0,04076477 0,07319201 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04076477 0,07313492 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04076477 0,07307792 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04076477 0,073021 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04076477 0,07296418 ! ribosome assembly GO:0042255 13 11 0,000 0,04076477 0,07290744 ! histone deacetylation GO:0016575 13 11 0,000 0,04076477 0,07285079 ! chromatin silencing GO:0006342 19 11 0,000 0,04076477 0,07279423 ! nucleosome positioning GO:0016584 13 11 0,000 0,04076477 0,07273776 ! T cell homeostasis GO:0043029 20 11 0,000 0,04076477 0,07268137 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04076477 0,07262507 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04076477 0,07256886 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04076477 0,07251274 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04076477 0,0724567 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04076477 0,07240075 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04076477 0,07234488 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,04076477 0,0722891 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04076477 0,07223341 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04076477 0,0721778 ! cholesterol efflux GO:0033344 19 11 0,000 0,04076477 0,07212228 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,04076477 0,07206685 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04076477 0,0720115 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,04076477 0,07195623 ! germ cell migration GO:0008354 18 11 0,000 0,04076477 0,07190105 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04076477 0,07184595 ! defense response to fungus GO:0050832 12 11 0,000 0,04076477 0,07179094 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04076477 0,07173601 ! lysogeny GO:0030069 18 11 0,000 0,04076477 0,07168117 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04076477 0,07162641 ! acrosome reaction GO:0007340 13 11 0,000 0,04076477 0,07157173 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04076477 0,07151714 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,04100592 0,07188538 ! regulation of membrane potential GO:0042391 128 85 1,000 0,04100592 0,07183063 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,04188209 0,07330959 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,04365549 0,07635562 ! establishment of RNA localization GO:0051236 128 88 1,000 0,04365549 0,0762976 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! lactation GO:0007595 20 12 0,000 0,04438846 0,07751971 ! reproductive cellular process GO:0048610 14 12 0,000 0,04438846 0,07746089 ! tRNA modification GO:0006400 14 12 0,000 0,04438846 0,07740217 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04438846 0,07734353 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04438846 0,07728498 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04438846 0,07722652 ! non-recombinational repair GO:0000726 19 12 0,000 0,04438846 0,07716815 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04438846 0,07710986 ! peroxisomal transport GO:0043574 21 12 0,000 0,04438846 0,07705167 ! cartilage condensation GO:0001502 18 12 0,000 0,04438846 0,07699356 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04438846 0,07693554 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04438846 0,0768776 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04438846 0,07681976 ! heart looping GO:0001947 15 12 0,000 0,04438846 0,076762 ! palate development GO:0060021 15 12 0,000 0,04438846 0,07670433 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,04438846 0,07664674 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04438846 0,07658924 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04438846 0,07653183 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04438846 0,0764745 ! arginine metabolic process GO:0006525 13 12 0,000 0,04438846 0,07641726 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04438846 0,0763601 ! methionine metabolic process GO:0006555 13 12 0,000 0,04438846 0,07630303 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04438846 0,07624605 ! Golgi organization GO:0007030 18 12 0,000 0,04438846 0,07618915 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04438846 0,07613233 ! monoamine transport GO:0015844 13 12 0,000 0,04438846 0,0760756 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04438846 0,07601896 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04438846 0,0759624 ! L-amino acid transport GO:0015807 20 12 0,000 0,04438846 0,07590592 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04438846 0,07584952 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04438846 0,07579321 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04438846 0,07573699 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04438846 0,07568084 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04438846 0,07562478 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04438846 0,07556881 ! cerebellum development GO:0021549 13 12 0,000 0,04438846 0,07551291 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04438846 0,0754571 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04438846 0,07540137 ! histone methylation GO:0016571 15 12 0,000 0,04438846 0,07534573 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04438846 0,07529016 ! gland morphogenesis GO:0022612 23 12 0,000 0,04438846 0,07523468 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04438846 0,07517928 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04438846 0,07512396 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04438846 0,07506872 ! intestinal absorption GO:0050892 19 12 0,000 0,04438846 0,07501356 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04438846 0,07495849 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04438846 0,07490349 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,04438846 0,07484858 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04438846 0,07479374 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,04438846 0,07473899 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04438846 0,07468432 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04438846 0,07462972 ! microspike assembly GO:0030035 23 12 0,000 0,04438846 0,07457521 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04438846 0,07452077 ! response to cold GO:0009409 14 12 0,000 0,04438846 0,07446642 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,04455261 0,07468732 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,04455261 0,07463292 ! regulation of T cell activation GO:0050863 128 89 1,000 0,04455261 0,0745786 ! leukocyte differentiation GO:0002521 143 90 1,000 0,04545658 0,07603646 ! RNA localization GO:0006403 135 91 1,000 0,04636734 0,07750355 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,04728484 0,07897976 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,04728484 0,07892244 ! DNA recombination GO:0006310 146 92 1,000 0,04728484 0,07886521 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,04799867 0,07999778 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,04799867 0,07993986 ! cGMP metabolic process GO:0046068 16 13 0,000 0,04799867 0,07988201 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,04799867 0,07982425 ! water transport GO:0006833 17 13 0,000 0,04799867 0,07976658 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,04799867 0,07970898 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,04799867 0,07965147 ! lipid localization GO:0010876 24 13 0,000 0,04799867 0,07959405 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,04799867 0,0795367 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,04799867 0,07947944 ! organelle fusion GO:0048284 28 13 0,000 0,04799867 0,07942226 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,04799867 0,07936516 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,04799867 0,07930815 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,04799867 0,07925121 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,04799867 0,07919436 ! response to hexose stimulus GO:0009746 19 13 0,000 0,04799867 0,07913759 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,04799867 0,0790809 ! glutamate metabolic process GO:0006536 18 13 0,000 0,04799867 0,0790243 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,04799867 0,07896777 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,04799867 0,07891132 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,04799867 0,07885496 ! NAD metabolic process GO:0019674 21 13 0,000 0,04799867 0,07879867 ! exocrine system development GO:0035272 27 13 0,000 0,04799867 0,07874247 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,04799867 0,07868634 ! bone mineralization GO:0030282 15 13 0,000 0,04799867 0,0786303 ! regulation of exocytosis GO:0017157 17 13 0,000 0,04799867 0,07857434 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,04799867 0,07851845 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,04799867 0,07846264 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,04799867 0,07840692 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,04799867 0,07835127 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,04799867 0,0782957 ! cellular pigmentation GO:0033059 24 13 0,000 0,04799867 0,07824021 ! tissue regeneration GO:0042246 21 13 0,000 0,04799867 0,0781848 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,04799867 0,07812947 ! cofactor transport GO:0051181 19 13 0,000 0,04799867 0,07807422 ! NADP metabolic process GO:0006739 18 13 0,000 0,04799867 0,07801904 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,04799867 0,07796394 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,04799867 0,07790892 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,04799867 0,07785398 ! gas transport GO:0015669 18 13 0,000 0,04799867 0,07779911 ! regulation of RNA stability GO:0043487 28 13 0,000 0,04799867 0,07774432 ! heme biosynthetic process GO:0006783 20 13 0,000 0,04799867 0,07768961 ! regulation of axon extension GO:0030516 23 13 0,000 0,04799867 0,07763498 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,04799867 0,07758042 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,04799867 0,07752594 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,04799867 0,07747154 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,04799867 0,07741721 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,04799867 0,07736296 ! response to oxidative stress GO:0006979 141 94 1,000 0,04913977 0,07914669 ! angiogenesis GO:0001525 149 95 1,000 0,05007708 0,08059992 ! carboxylic acid transport GO:0046942 147 95 1,000 0,05007708 0,08054356 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,05102088 0,08200422 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,05159545 0,08286978 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,05159545 0,08281195 ! superoxide anion generation GO:0042554 18 14 0,000 0,05159545 0,0827542 ! neuron maturation GO:0042551 21 14 0,000 0,05159545 0,08269653 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,05159545 0,08263895 ! myotube differentiation GO:0014902 21 14 0,000 0,05159545 0,08258144 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,05159545 0,08252401 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,05159545 0,08246666 ! inositol metabolic process GO:0006020 20 14 0,000 0,05159545 0,08240939 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,05159545 0,0823522 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,05159545 0,0822951 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,05159545 0,08223806 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,05159545 0,08218111 ! gene silencing by RNA GO:0031047 20 14 0,000 0,05159545 0,08212424 ! response to cAMP GO:0051591 19 14 0,000 0,05159545 0,08206745 ! limbic system development GO:0021761 25 14 0,000 0,05159545 0,08201073 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,05159545 0,08195409 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,05159545 0,08189753 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,05159545 0,08184105 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,05159545 0,08178465 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,05159545 0,08172832 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,05159545 0,08167208 ! glycine metabolic process GO:0006544 22 14 0,000 0,05159545 0,08161591 ! pituitary gland development GO:0021983 23 14 0,000 0,05159545 0,08155981 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,05159545 0,0815038 GO:0031114|regulation of microtubule depolymerization, ! regulation of heart rate GO:0002027 23 14 0,000 0,05159545 0,08144786 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,05159545 0,08139199 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,05159545 0,08133621 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,05159545 0,0812805 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,05159545 0,08122486 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,05159545 0,08116931 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,05159545 0,08111383 ! axon cargo transport GO:0008088 27 14 0,000 0,05159545 0,08105842 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,05159545 0,08100309 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,05159545 0,08094784 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,05159545 0,08089266 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,05159545 0,08083755 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,05159545 0,08078252 ! mRNA splice site selection GO:0006376 26 14 0,000 0,05159545 0,08072757 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,05159545 0,08067269 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,05159545 0,08061789 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,05159545 0,08056315 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,05159545 0,0805085 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,05159545 0,08045392 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,05159545 0,08039941 ! muscle maintenance GO:0046716 19 14 0,000 0,05159545 0,08034497 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,05159545 0,08029061 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,05159545 0,08023633 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,05159545 0,08018211 ! cell killing GO:0001906 20 14 0,000 0,05159545 0,08012797 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,05159545 0,0800739 ! cilium assembly GO:0042384 20 14 0,000 0,05159545 0,08001991 ! peptide hormone secretion GO:0030072 23 14 0,000 0,05159545 0,07996599 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,05197111 0,08049397 ! protein import GO:0017038 156 99 1,000 0,05389059 0,08341073 ! regulation of translation GO:0006417 151 100 1,000 0,05485972 0,08485364 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,05485972 0,08479661 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,05485972 0,08473966 ! protein localization in organelle GO:0033365 161 100 1,000 0,05485972 0,08468279 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,05517884 0,08511826 ! positive regulation of cell size GO:0045793 20 15 0,000 0,05517884 0,08506121 ! metencephalon development GO:0022037 19 15 0,000 0,05517884 0,08500424 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,05517884 0,08494734 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,05517884 0,08489052 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,05517884 0,08483378 ! skin development GO:0043588 25 15 0,000 0,05517884 0,08477711 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,05517884 0,08472051 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,05517884 0,084664 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,05517884 0,08460755 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,05517884 0,08455119 ! bile acid metabolic process GO:0008206 22 15 0,000 0,05517884 0,08449489 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,05517884 0,08443868 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,05517884 0,08438253 ! adult walking behavior GO:0007628 25 15 0,000 0,05517884 0,08432647 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,05517884 0,08427047 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,05517884 0,08421455 ! myoblast differentiation GO:0045445 27 15 0,000 0,05517884 0,08415871 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,05517884 0,08410294 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,05517884 0,08404724 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,05517884 0,08399161 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,05517884 0,08393606 ! cerebral cortex development GO:0021987 29 15 0,000 0,05517884 0,08388059 ! response to osmotic stress GO:0006970 22 15 0,000 0,05517884 0,08382518 ! vesicle coating GO:0006901 25 15 0,000 0,05517884 0,08376985 ! DNA integration GO:0015074 22 15 0,000 0,05517884 0,0837146 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,05517884 0,08365941 ! peptide secretion GO:0002790 27 15 0,000 0,05517884 0,0836043 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,05517884 0,08354926 ! regulation of vasodilation GO:0042312 24 15 0,000 0,05517884 0,0834943 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,05517884 0,0834394 ! neuron recognition GO:0008038 22 15 0,000 0,05517884 0,08338458 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,05517884 0,08332983 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,05517884 0,08327515 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,05517884 0,08322054 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,05517884 0,08316601 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,05517884 0,08311155 ! biomineral formation GO:0031214 18 15 0,000 0,05517884 0,08305715 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,05517884 0,08300283 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,05517884 0,08294858 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,05517884 0,0828944 ! dopamine metabolic process GO:0042417 30 15 0,000 0,05517884 0,08284029 ! organic cation transport GO:0015695 19 15 0,000 0,05517884 0,08278626 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,05517884 0,08273229 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,05517884 0,08267839 ! defense response to virus GO:0051607 27 15 0,000 0,05517884 0,08262456 ! peptide hormone processing GO:0016486 19 15 0,000 0,05517884 0,08257081 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,05517884 0,08251712 ! protein secretion GO:0009306 27 16 0,000 0,0587489 0,08779887 ! hormone secretion GO:0046879 25 16 0,000 0,0587489 0,08774186 ! bone remodeling GO:0046849 24 16 0,000 0,0587489 0,08768492 ! endothelial cell migration GO:0043542 22 16 0,000 0,0587489 0,08762806 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,0587489 0,08757127 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,0587489 0,08751455 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,0587489 0,0874579 ! glial cell development GO:0021782 24 16 0,000 0,0587489 0,08740133 ! patterning of blood vessels GO:0001569 24 16 0,000 0,0587489 0,08734484 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,0587489 0,08728841 GO:0042744|hydrogen peroxide catabolic process, ! protein polyubiquitination GO:0000209 26 16 0,000 0,0587489 0,08723206 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,0587489 0,08717578 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,0587489 0,08711958 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,0587489 0,08706344 ! fructose metabolic process GO:0006000 20 16 0,000 0,0587489 0,08700738 ! regulation of protein binding GO:0043393 27 16 0,000 0,0587489 0,08695139 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,0587489 0,08689547 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,0587489 0,08683963 ! protein export from nucleus GO:0006611 24 16 0,000 0,0587489 0,08678386 ! negative regulation of immune response GO:0050777 28 16 0,000 0,0587489 0,08672815 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,0587489 0,08667252 ! DNA replication initiation GO:0006270 25 16 0,000 0,0587489 0,08661696 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,0587489 0,08656148 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,0587489 0,08650606 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,0587489 0,08645071 ! diencephalon development GO:0021536 25 16 0,000 0,0587489 0,08639544 ! neural crest cell migration GO:0001755 24 16 0,000 0,0587489 0,08634023 ! G1 phase GO:0051318 27 16 0,000 0,0587489 0,0862851 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,0587489 0,08623003 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,0587489 0,08617504 ! steroid catabolic process GO:0006706 22 16 0,000 0,0587489 0,08612012 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,0587489 0,08606526 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,0587489 0,08601048 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,0587489 0,08595576 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,0587489 0,08590112 ! sperm-egg recognition GO:0035036 16 16 0,000 0,0587489 0,08584655 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,0587489 0,08579204 ! nerve development GO:0021675 18 16 0,000 0,0587489 0,0857376 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,0587489 0,08568324 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,0587489 0,08562894 ! negative regulation of translation GO:0017148 22 16 0,000 0,0587489 0,08557471 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,06230567 0,09069812 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,06230567 0,09064076 ! negative regulation of defense response GO:0031348 19 17 0,000 0,06230567 0,09058346 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,06230567 0,09052624 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,06230567 0,09046909 ! glycerol metabolic process GO:0006071 20 17 0,000 0,06230567 0,09041201 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,06230567 0,090355 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,06230567 0,09029807 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,06230567 0,09024121 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,06230567 0,09018442 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,06230567 0,0901277 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,06230567 0,09007105 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,06230567 0,09001447 ! memory GO:0007613 25 17 0,000 0,06230567 0,08995796 ! keratinization GO:0031424 17 17 0,000 0,06230567 0,08990153 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,06230567 0,08984516 ! retinoid metabolic process GO:0001523 22 17 0,000 0,06230567 0,08978887 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,06230567 0,08973265 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,06230567 0,08967649 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,06230567 0,08962041 GO:0032392|DNA geometric change, ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,06230567 0,0895644 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,06230567 0,08950846 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,06230567 0,08945258 ! membrane budding GO:0006900 29 17 0,000 0,06230567 0,08939678 ! heme metabolic process GO:0042168 27 17 0,000 0,06230567 0,08934105 ! actin filament bundle formation GO:0051017 26 17 0,000 0,06230567 0,08928538 ! body fluid secretion GO:0007589 27 17 0,000 0,06230567 0,08922979 ! stem cell differentiation GO:0048863 36 17 0,000 0,06230567 0,08917426 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,06230567 0,0891188 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,06230567 0,08906342 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,06230567 0,0890081 ! sensory perception of pain GO:0019233 23 17 0,000 0,06230567 0,08895285 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,06230567 0,08889767 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,06230567 0,08884255 ! synaptogenesis GO:0007416 24 17 0,000 0,06230567 0,08878751 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,06230567 0,08873253 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,06230567 0,08867762 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,06230567 0,08862278 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,06230567 0,08856801 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,06230567 0,0885133 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,06230567 0,08845866 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,06230567 0,08840409 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,06230567 0,08834959 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,06230567 0,08829516 ! positive regulation of translation GO:0045727 28 18 0,000 0,0658492 0,09325934 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,0658492 0,09320195 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,0658492 0,09314463 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,0658492 0,09308738 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,0658492 0,0930302 ! cAMP metabolic process GO:0046058 33 18 0,000 0,0658492 0,09297309 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,0658492 0,09291605 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,0658492 0,09285908 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,0658492 0,09280219 ! axis specification GO:0009798 26 18 0,000 0,0658492 0,09274536 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,0658492 0,0926886 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,0658492 0,09263191 ! pancreas development GO:0031016 26 18 0,000 0,0658492 0,09257528 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,0658492 0,09251873 ! glutamine metabolic process GO:0006541 23 18 0,000 0,0658492 0,09246225 ! response to retinoic acid GO:0032526 25 18 0,000 0,0658492 0,09240584 ! central nervous system neuron development GO:0021954 30 18 0,000 0,0658492 0,09234949 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,0658492 0,09229322 ! fucose metabolic process GO:0006004 26 18 0,000 0,0658492 0,09223701 ! response to fungus GO:0009620 19 18 0,000 0,0658492 0,09218087 ! peptide cross-linking GO:0018149 31 18 0,000 0,0658492 0,0921248 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,0658492 0,09206879 ! heart process GO:0003015 27 18 0,000 0,0658492 0,09201286 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,0658492 0,09195699 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,0658492 0,09190119 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,0658492 0,09184546 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,0658492 0,0917898 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,0658492 0,0917342 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,0658492 0,09167867 ! vitamin transport GO:0051180 24 18 0,000 0,0658492 0,09162321 ! hormone transport GO:0009914 27 18 0,000 0,0658492 0,09156781 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,0658492 0,09151249 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,0658492 0,09145723 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,0658492 0,09140203 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,0658492 0,0913469 ! cell-cell recognition GO:0009988 20 18 0,000 0,0658492 0,09129184 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,0658492 0,09123685 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,0658492 0,09118192 ! gut development GO:0048565 26 18 0,000 0,0658492 0,09112706 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,0658492 0,09107226 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,06937955 0,09589721 ! positive regulation of ossification GO:0045778 30 19 0,000 0,06937955 0,09583962 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,06937955 0,09578209 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,06937955 0,09572463 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,06937955 0,09566724 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,06937955 0,09560992 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,06937955 0,09555267 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,06937955 0,09549549 ! regeneration GO:0031099 32 19 0,000 0,06937955 0,09543837 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,06937955 0,09538133 ! response to alkaloid GO:0043279 32 19 0,000 0,06937955 0,09532435 ! sensory perception of taste GO:0050909 23 19 0,000 0,06937955 0,09526744 ! smooth muscle contraction GO:0006939 36 19 0,000 0,06937955 0,0952106 ! peroxisome organization GO:0007031 29 19 0,000 0,06937955 0,09515382 ! digestive system process GO:0022600 30 19 0,000 0,06937955 0,09509712 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,06937955 0,09504048 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,06937955 0,09498391 ! response to vitamin A GO:0033189 26 19 0,000 0,06937955 0,0949274 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,06937955 0,09487096 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,06937955 0,09481459 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,06937955 0,09475829 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,06937955 0,09470205 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,06937955 0,09464588 ! plasma membrane fusion GO:0045026 23 19 0,000 0,06937955 0,09458978 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,06937955 0,09453374 ! cytolysis GO:0019835 20 19 0,000 0,06937955 0,09447777 ! renal system process GO:0003014 35 19 0,000 0,06937955 0,09442187 ! vasodilation GO:0042311 33 19 0,000 0,06937955 0,09436603 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,06937955 0,09431026 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,06937955 0,09425455 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,06937955 0,09419891 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,06937955 0,09414334 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,06937955 0,09408783 ! sarcomere organization GO:0045214 23 19 0,000 0,06937955 0,09403239 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,06937955 0,09397701 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,06937955 0,0939217 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,06937955 0,09386645 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,06937955 0,09381126 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,06937955 0,09375615 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,06937955 0,09370109 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,06937955 0,0936461 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,06937955 0,09359118 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,07289675 0,09827815 ! iron ion transport GO:0006826 37 20 0,000 0,07289675 0,09822058 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,07289675 0,09816307 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,07289675 0,09810564 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,07289675 0,09804826 ! response to vitamin GO:0033273 29 20 0,000 0,07289675 0,09799096 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,07289675 0,09793372 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,07289675 0,09787655 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,07289675 0,09781945 ! spinal cord development GO:0021510 31 20 0,000 0,07289675 0,09776241 ! response to ethanol GO:0045471 37 20 0,000 0,07289675 0,09770544 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,07289675 0,09764853 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,07289675 0,09759169 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,07289675 0,09753492 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,07289675 0,09747822 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,07289675 0,09742158 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,07289675 0,097365 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,07289675 0,09730849 ! pallium development GO:0021543 38 20 0,000 0,07289675 0,09725205 ! DNA modification GO:0006304 28 20 0,000 0,07289675 0,09719567 ! collagen fibril organization GO:0030199 45 20 0,000 0,07289675 0,09713936 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,07289675 0,09708311 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,07289675 0,09702693 ! collagen catabolic process GO:0030574 25 20 0,000 0,07289675 0,09697081 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,07289675 0,09691476 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,07289675 0,09685877 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,07289675 0,09680285 ! alditol metabolic process GO:0019400 24 20 0,000 0,07289675 0,09674699 ! actin filament-based movement GO:0030048 34 20 0,000 0,07289675 0,09669119 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,07640087 0,10128069 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,07640087 0,10122234 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,07640087 0,10116407 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,07640087 0,10110586 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,07640087 0,10104772 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,07640087 0,10098965 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,07640087 0,10093164 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,07640087 0,1008737 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,07640087 0,10081583 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,07640087 0,10075802 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,07640087 0,10070028 ! vesicle docking GO:0048278 27 21 0,000 0,07640087 0,10064261 ! phototransduction GO:0007602 25 21 0,000 0,07640087 0,100585 ! dendrite development GO:0016358 35 21 0,000 0,07640087 0,10052745 ! visual behavior GO:0007632 39 21 0,000 0,07640087 0,10046998 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,07640087 0,10041257 ! ovarian follicle development GO:0001541 30 21 0,000 0,07640087 0,10035522 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,07640087 0,10029794 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,07640087 0,10024072 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,07640087 0,10018358 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,07640087 0,10012649 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,07640087 0,10006947 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,07640087 0,10001252 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,07640087 0,09995563 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,07640087 0,0998988 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,07640087 0,09984204 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,07640087 0,09978534 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,07640087 0,09972871 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,07640087 0,09967214 ! fatty acid transport GO:0015908 30 21 0,000 0,07640087 0,09961564 ! immunoglobulin production GO:0002377 33 21 0,000 0,07640087 0,0995592 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,07640087 0,09950283 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,07640087 0,09944651 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,07640087 0,09939027 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,07640087 0,09933408 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,07640087 0,09927796 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,07640087 0,0992219 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,07640087 0,09916591 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,07640087 0,09910998 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,07640087 0,09905411 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,07640087 0,0989983 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,07640087 0,09894256 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,07640087 0,09888688 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,07640087 0,09883127 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,07640087 0,09877571 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,07989193 0,10323115 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,07989193 0,10317319 ! viral genome replication GO:0019079 29 22 0,000 0,07989193 0,10311529 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,07989193 0,10305746 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,07989193 0,10299969 ! leukocyte adhesion GO:0007159 38 22 0,000 0,07989193 0,10294199 ! molting cycle process GO:0022404 40 22 0,000 0,07989193 0,10288435 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,07989193 0,10282678 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,07989193 0,10276927 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,07989193 0,10271182 ! vasculogenesis GO:0001570 33 22 0,000 0,07989193 0,10265444 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,07989193 0,10259712 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,07989193 0,10253987 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,07989193 0,10248268 ! lysosome organization GO:0007040 37 22 0,000 0,07989193 0,10242556 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,07989193 0,10236849 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,07989193 0,1023115 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,07989193 0,10225456 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,07989193 0,10219769 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,07989193 0,10214088 ! membrane depolarization GO:0051899 35 22 0,000 0,07989193 0,10208414 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,07989193 0,10202746 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,07989193 0,10197084 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,07989193 0,10191428 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,07989193 0,10185779 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,07989193 0,10180136 ! neural tube closure GO:0001843 33 22 0,000 0,07989193 0,10174499 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,07989193 0,10168868 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,08337001 0,10605698 ! neuron fate commitment GO:0048663 32 23 0,000 0,08337001 0,10599835 ! embryonic pattern specification GO:0009880 31 23 0,000 0,08337001 0,10593979 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,08337001 0,10588129 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,08337001 0,10582285 ! vesicle targeting GO:0006903 32 23 0,000 0,08337001 0,10576449 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,08337001 0,10570618 ! osteoblast differentiation GO:0001649 40 23 0,000 0,08337001 0,10564794 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,08337001 0,10558976 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,08337001 0,10553165 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,08337001 0,1054736 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,08337001 0,10541562 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,08337001 0,1053577 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,08337001 0,10529984 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,08337001 0,10524205 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,08337001 0,10518432 ! cell fate determination GO:0001709 45 23 0,000 0,08337001 0,10512665 ! pentose metabolic process GO:0019321 31 23 0,000 0,08337001 0,10506905 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,08337001 0,10501151 ! spermatid development GO:0007286 33 23 0,000 0,08337001 0,10495403 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,08337001 0,10489662 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,08337001 0,10483926 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,08337001 0,10478197 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,08337001 0,10472475 ! telomere organization GO:0032200 32 23 0,000 0,08337001 0,10466758 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,08337001 0,10461048 ! regulation of amine transport GO:0051952 38 23 0,000 0,08337001 0,10455344 ! liver development GO:0001889 40 23 0,000 0,08337001 0,10449646 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,08683513 0,10878039 ! initiation of viral infection GO:0019059 42 24 0,000 0,08683513 0,10872117 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,08683513 0,10866202 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,08683513 0,10860293 ! superoxide metabolic process GO:0006801 32 24 0,000 0,08683513 0,10854391 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,08683513 0,10848495 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,08683513 0,10842606 ! fat cell differentiation GO:0045444 37 24 0,000 0,08683513 0,10836722 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,08683513 0,10830846 ! sperm motility GO:0030317 27 24 0,000 0,08683513 0,10824975 ! vacuole organization GO:0007033 39 24 0,000 0,08683513 0,10819111 ! neural crest cell development GO:0014032 39 24 0,000 0,08683513 0,10813254 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 0,000 0,08683513 0,10807402 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,08683513 0,10801557 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,08683513 0,10795719 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,08683513 0,10789886 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,08683513 0,1078406 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,08683513 0,1077824 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,08683513 0,10772427 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,09028735 0,11194658 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,09028735 0,11188626 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,09028735 0,11182601 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,09028735 0,11176583 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,09028735 0,1117057 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,09028735 0,11164565 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,09028735 0,11158566 ! peptide transport GO:0015833 43 25 0,000 0,09028735 0,11152573 ! male gonad development GO:0008584 33 25 0,000 0,09028735 0,11146586 ! iron ion homeostasis GO:0055072 39 25 0,000 0,09028735 0,11140606 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,09028735 0,11134633 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,09028735 0,11128666 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,09028735 0,11122705 ! phospholipid transport GO:0015914 35 25 0,000 0,09028735 0,11116751 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,09028735 0,11110803 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,09028735 0,11104861 ! detection of light stimulus GO:0009583 30 25 0,000 0,09028735 0,11098926 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,09028735 0,11092997 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,09028735 0,11087074 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,09372672 0,11503279 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,09372672 0,11497144 ! translational initiation GO:0006413 43 26 0,000 0,09372672 0,11491015 ! circadian rhythm GO:0007623 42 26 0,000 0,09372672 0,11484893 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,09372672 0,11478778 ! post-embryonic development GO:0009791 42 26 0,000 0,09372672 0,11472669 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,09372672 0,11466566 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,09372672 0,1146047 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,09372672 0,11454381 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,09372672 0,11448298 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,09372672 0,11442221 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,09372672 0,11436151 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,09372672 0,11430087 ! regulation of coagulation GO:0050818 39 26 0,000 0,09372672 0,1142403 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,09715328 0,1183541 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,09715328 0,11829144 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,09715328 0,11822886 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,09715328 0,11816633 ! membrane docking GO:0022406 39 27 0,000 0,09715328 0,11810388 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,09715328 0,11804149 ! catechol metabolic process GO:0009712 43 27 0,000 0,09715328 0,11797916 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,09715328 0,11791691 ! acute-phase response GO:0006953 42 27 0,000 0,09715328 0,11785471 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,09715328 0,11779259 ! myofibril assembly GO:0030239 36 27 0,000 0,09715328 0,11773053 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,09715328 0,11766853 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,09715328 0,1176066 ! natural killer cell activation GO:0030101 35 27 0,000 0,09715328 0,11754473 ! lipid oxidation GO:0034440 38 27 0,000 0,09715328 0,11748293 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,09715328 0,1174212 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,09715328 0,11735953 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,09715328 0,11729792 ! gene silencing GO:0016458 41 27 0,000 0,09715328 0,11723638 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,10056708 0,12129223 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,10056708 0,12122866 ! phenol metabolic process GO:0018958 44 28 0,000 0,10056708 0,12116515 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,10056708 0,12110172 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,10056708 0,12103835 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,10056708 0,12097504 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,10056708 0,1209118 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,10056708 0,12084863 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,10056708 0,12078552 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,10056708 0,12072248 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,10056708 0,12065951 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,10056708 0,1205966 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,10056708 0,12053376 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,10056708 0,12047098 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,10056708 0,12040827 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,10056708 0,12034562 ! mesoderm formation GO:0001707 46 28 0,000 0,10056708 0,12028304 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,10056708 0,12022052 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,10056708 0,12015807 ! BMP signaling pathway GO:0030509 40 28 0,000 0,10056708 0,12009568 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,10056708 0,12003336 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,10056708 0,1199711 ! neural tube formation GO:0001841 41 28 0,000 0,10056708 0,11990891 ! placenta development GO:0001890 37 28 0,000 0,10056708 0,11984678 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,10396816 0,12383572 ! regulation of innate immune response GO:0045088 38 29 0,000 0,10396816 0,12377162 ! ovulation cycle process GO:0022602 41 29 0,000 0,10396816 0,12370759 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,10396816 0,12364363 ! protein targeting to membrane GO:0006612 53 29 0,000 0,10396816 0,12357973 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,10396816 0,1235159 ! mismatch repair GO:0006298 34 29 0,000 0,10396816 0,12345213 ! muscle cell development GO:0055001 38 29 0,000 0,10396816 0,12338843 ! formation of primary germ layer GO:0001704 48 29 0,000 0,10396816 0,1233248 ! telencephalon development GO:0021537 52 29 0,000 0,10396816 0,12326123 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,10396816 0,12319772 ! eye morphogenesis GO:0048592 51 29 0,000 0,10396816 0,12313428 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,10396816 0,12307091 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,10735659 0,12701654 ! collagen metabolic process GO:0032963 40 30 0,000 0,10735659 0,12695123 ! cholesterol transport GO:0030301 46 30 0,000 0,10735659 0,12688599 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,10735659 0,12682082 ! spliceosome assembly GO:0000245 49 30 0,000 0,10735659 0,12675572 ! spindle organization GO:0007051 37 30 0,000 0,10735659 0,12669069 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,10735659 0,12662572 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,10735659 0,12656081 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,10735659 0,12649598 ! ceramide metabolic process GO:0006672 43 30 0,000 0,10735659 0,12643121 ! ovulation cycle GO:0042698 43 30 0,000 0,10735659 0,1263665 ! hindbrain development GO:0030902 45 30 0,000 0,10735659 0,12630186 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,10735659 0,12623729 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,10735659 0,12617279 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,10735659 0,12610835 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,10735659 0,12604397 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,10735659 0,12597967 ! negative regulation of secretion GO:0051048 49 31 0,000 0,11073239 0,1298748 ! glial cell differentiation GO:0010001 55 31 0,000 0,11073239 0,12980861 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,11073239 0,12974248 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,11073239 0,12967642 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,11073239 0,12961043 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,11073239 0,1295445 ! metanephros development GO:0001656 58 31 0,000 0,11073239 0,12947864 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,11073239 0,12941285 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,11073239 0,12934712 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,11073239 0,12928147 ! RNA modification GO:0009451 40 31 0,000 0,11073239 0,12921587 ! regulation of muscle development GO:0048634 48 32 0,000 0,11409561 0,13307298 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,11409561 0,13300553 ! meiosis I GO:0007127 52 32 0,000 0,11409561 0,13293815 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,11409561 0,13287084 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,11409561 0,1328036 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,11409561 0,13273642 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,11409561 0,13266932 ! cytokine production GO:0001816 44 32 0,000 0,11409561 0,13260228 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,11409561 0,13253531 ! vesicle localization GO:0051648 47 32 0,000 0,11409561 0,1324684 ! RNA export from nucleus GO:0006405 44 33 0,000 0,11744631 0,13628987 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,11744631 0,13622114 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,11744631 0,13615248 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,11744631 0,13608389 ! ear morphogenesis GO:0042471 42 33 0,000 0,11744631 0,13601536 ! actomyosin structure organization GO:0031032 43 33 0,000 0,11744631 0,13594691 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,11744631 0,13587853 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,11744631 0,13581021 ! nucleus organization GO:0006997 49 33 0,000 0,11744631 0,13574197 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,11744631 0,13567379 ! positive regulation of cell development GO:0010720 54 33 0,000 0,11744631 0,13560568 ! lipid homeostasis GO:0055088 55 33 0,000 0,11744631 0,13553764 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,11744631 0,13546967 ! regulation of proteolysis GO:0030162 50 33 0,000 0,11744631 0,13540176 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,11744631 0,13533392 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,11744631 0,13526616 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,11744631 0,13519846 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,12078453 0,13897169 ! mRNA catabolic process GO:0006402 48 34 0,000 0,12078453 0,13890221 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,12078453 0,13883279 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,12078453 0,13876344 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,12078453 0,13869416 ! feeding behavior GO:0007631 45 34 0,000 0,12078453 0,13862496 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,12078453 0,13855582 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,12078453 0,13848675 ! neuron migration GO:0001764 46 34 0,000 0,12078453 0,13841774 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,12078453 0,13834881 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,12078453 0,13827995 ! polyol metabolic process GO:0019751 44 34 0,000 0,12078453 0,13821115 ! aerobic respiration GO:0009060 47 34 0,000 0,12078453 0,13814242 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,12078453 0,13807376 ! embryonic organ development GO:0048568 45 34 0,000 0,12078453 0,13800517 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,12078453 0,13793665 ! Notch signaling pathway GO:0007219 56 35 0,000 0,12411031 0,14166437 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,12411031 0,1415941 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,12411031 0,1415239 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,12411031 0,14145377 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,12411031 0,14138371 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,12411031 0,14131372 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,12411031 0,14124379 ! glycogen metabolic process GO:0005977 48 35 0,000 0,12411031 0,14117394 ! pigment metabolic process GO:0042440 61 35 0,000 0,12411031 0,14110416 ! protein homooligomerization GO:0051260 52 35 0,000 0,12411031 0,14103444 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,1274237 0,14472815 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,1274237 0,14465672 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,1274237 0,14458535 ! organic ether metabolic process GO:0018904 46 36 0,000 0,1274237 0,14451406 ! tissue remodeling GO:0048771 62 36 0,000 0,1274237 0,14444283 ! neural tube development GO:0021915 50 36 0,000 0,1274237 0,14437168 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,1274237 0,14430059 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,1274237 0,14422958 ! glucan metabolic process GO:0044042 49 36 0,000 0,1274237 0,14415864 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,13072474 0,14782051 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,13072474 0,14774787 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,13072474 0,1476753 ! learning GO:0007612 67 37 0,000 0,13072474 0,1476028 ! ion transmembrane transport GO:0034220 56 37 0,000 0,13072474 0,14753038 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,13072474 0,14745802 ! regulation of protein secretion GO:0050708 51 37 0,000 0,13072474 0,14738574 ! amino acid activation GO:0043038 52 37 0,000 0,13072474 0,14731353 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,13072474 0,14724139 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,13401349 0,15087177 ! gliogenesis GO:0042063 71 38 0,000 0,13401349 0,15079796 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,13401349 0,15072422 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,13401349 0,15065055 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,13401349 0,15057695 ! phagocytosis GO:0006909 60 38 0,000 0,13401349 0,15050343 ! mesenchymal cell development GO:0014031 64 38 0,000 0,13401349 0,15042998 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,13728998 0,15403266 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,13728998 0,15395756 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,13728998 0,15388253 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,13728998 0,15380758 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,13728998 0,15373269 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,13728998 0,15365788 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,13728998 0,15358315 ! chromatin remodeling GO:0006338 68 39 0,000 0,13728998 0,15350848 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,13728998 0,15343389 ! JNK cascade GO:0007254 54 39 0,000 0,13728998 0,15335938 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,14055426 0,15692951 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,14055426 0,15685337 ! regulation of tube size GO:0035150 60 40 0,000 0,14055426 0,1567773 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,14055426 0,15670131 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,14055426 0,15662539 ! inner ear development GO:0048839 57 40 0,000 0,14055426 0,15654954 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,14055426 0,15647377 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,14055426 0,15639807 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,14055426 0,15632244 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,14055426 0,15624688 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,14380638 0,15978486 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,14380638 0,15970771 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,14380638 0,15963063 ! glucose transport GO:0015758 52 41 0,000 0,14380638 0,15955363 ! striated muscle contraction GO:0006941 62 41 0,000 0,14380638 0,1594767 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,14380638 0,15939984 ! biopolymer methylation GO:0043414 62 41 0,000 0,14380638 0,15932306 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,14380638 0,15924635 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,14704637 0,16275585 ! cellular component disassembly GO:0022411 64 42 0,000 0,14704637 0,16267757 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,14704637 0,16259936 ! hexose transport GO:0008645 54 42 0,000 0,14704637 0,16252122 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,14704637 0,16244316 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,14704637 0,16236518 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,14704637 0,16228727 ! excretion GO:0007588 63 42 0,000 0,14704637 0,16220943 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,14704637 0,16213167 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,14704637 0,16205398 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,14704637 0,16197637 ! regulation of cell shape GO:0008360 78 42 0,000 0,14704637 0,16189883 ! tRNA processing GO:0008033 49 43 0,000 0,1502743 0,16537363 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,1502743 0,16529454 ! vesicle organization GO:0016050 79 43 0,000 0,1502743 0,16521553 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,1502743 0,16513659 ! methylation GO:0032259 64 43 0,000 0,1502743 0,16505773 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,15349018 0,16850951 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,15349018 0,16842911 ! glycolysis GO:0006096 53 44 0,000 0,15349018 0,1683488 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,15349018 0,16826855 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,15349018 0,16818839 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,15349018 0,1681083 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,15349018 0,16802828 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,15349018 0,16794835 ! RNA catabolic process GO:0006401 64 45 0,000 0,15669409 0,17137252 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,15669409 0,17129106 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,15669409 0,17120969 ! cell recognition GO:0008037 58 45 0,000 0,15669409 0,1711284 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,15988605 0,17453152 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,15988605 0,17444872 ! cell redox homeostasis GO:0045454 63 46 0,000 0,15988605 0,17436601 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,15988605 0,17428337 ! regulation of ossification GO:0030278 71 46 0,000 0,15988605 0,17420081 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,15988605 0,17411833 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,16306611 0,17749742 ! viral infectious cycle GO:0019058 71 47 0,000 0,16306611 0,17741345 ! endocrine system development GO:0035270 83 47 0,000 0,16306611 0,17732957 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,16306611 0,17724577 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,16306611 0,17716204 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,16306611 0,1770784 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,16306611 0,17699483 ! chloride transport GO:0006821 67 48 0,000 0,16623431 0,18034854 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,16623431 0,18026351 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,16623431 0,18017856 ! gastrulation GO:0007369 73 48 0,000 0,16623431 0,18009369 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,16623431 0,1800089 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,16623431 0,17992419 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,16623431 0,17983956 ! regulation of endocytosis GO:0030100 63 48 0,000 0,16623431 0,17975501 ! nuclear export GO:0051168 69 48 0,000 0,16623431 0,17967054 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,16623431 0,17958615 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,1693907 0,18291015 ! sensory perception of smell GO:0007608 61 49 0,000 0,1693907 0,18282431 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,1693907 0,18273856 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,1693907 0,18265289 ! RNA elongation GO:0006354 62 49 0,000 0,1693907 0,1825673 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,1693907 0,18248179 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,1693907 0,18239635 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,1693907 0,182311 ! regulation of actin filament length GO:0030832 72 50 0,000 0,17253532 0,18560863 ! ear development GO:0043583 72 50 0,000 0,17253532 0,18552185 ! membrane fusion GO:0006944 80 50 0,000 0,17253532 0,18543516 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,17253532 0,18534855 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,17253532 0,18526202 ! proton transport GO:0015992 75 50 0,000 0,17253532 0,18517557 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,17253532 0,1850892 ! positive regulation of secretion GO:0051047 71 51 0,000 0,17566822 0,1883622 ! hydrogen transport GO:0006818 77 51 0,000 0,17566822 0,18827442 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,17566822 0,18818673 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,17566822 0,18809912 ! transition metal ion transport GO:0000041 74 52 0,000 0,17878944 0,19135212 ! regulation of cellular component size GO:0032535 74 52 0,000 0,17878944 0,19126312 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,17878944 0,1911742 ! establishment of organelle localization GO:0051656 85 52 0,000 0,17878944 0,19108536 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,18189901 0,1943185 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,18189901 0,19422829 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,18189901 0,19413816 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,18189901 0,19404811 ! kidney development GO:0001822 90 53 0,000 0,18189901 0,19395815 ! single fertilization GO:0007338 59 53 0,000 0,18189901 0,19386827 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,18499699 0,19707878 ! regulation of mitosis GO:0007088 84 54 0,000 0,18499699 0,19698754 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,18499699 0,19689638 ! DNA catabolic process GO:0006308 67 54 0,000 0,18499699 0,19680531 ! detection of external stimulus GO:0009581 66 54 0,000 0,18499699 0,19671432 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,18499699 0,19662342 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,18499699 0,1965326 ! exocytosis GO:0006887 74 55 0,000 0,18808341 0,19971923 ! mesoderm development GO:0007498 76 55 0,000 0,18808341 0,19962707 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,18808341 0,19953499 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,18808341 0,19944299 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,19115833 0,20261021 ! carbohydrate transport GO:0008643 74 57 0,000 0,19422177 0,20576235 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,19422177 0,20566762 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,19422177 0,20557297 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,19422177 0,20547841 ! camera-type eye development GO:0043010 88 57 0,000 0,19422177 0,20538394 ! secondary metabolic process GO:0019748 84 57 0,000 0,19422177 0,20528955 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,19727378 0,20841971 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,19727378 0,20832401 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,20031441 0,21143789 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,20031441 0,2113409 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,20031441 0,21124399 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,2033437 0,21434029 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,2033437 0,2142421 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,2033437 0,21414401 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,2033437 0,214046 ! fertilization GO:0009566 68 60 0,000 0,2033437 0,21394808 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,2033437 0,21385026 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,20636168 0,21692499 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,20636168 0,21682589 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,20636168 0,21672688 ! urogenital system development GO:0001655 101 61 0,000 0,20636168 0,21662797 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,20636168 0,21652914 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,20636168 0,2164304 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,20636168 0,21633176 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,20636168 0,2162332 ! amine catabolic process GO:0009310 90 62 0,000 0,20936841 0,21928385 ! neurotransmitter transport GO:0006836 81 62 0,000 0,20936841 0,21918404 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,20936841 0,21908432 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,20936841 0,21898469 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,20936841 0,21888515 ! organelle localization GO:0051640 96 62 0,000 0,20936841 0,21878571 ! appendage morphogenesis GO:0035107 93 64 0,000 0,21534824 0,22493231 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,21534824 0,22483021 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,21534824 0,2247282 ! hexose catabolic process GO:0019320 82 64 0,000 0,21534824 0,22462628 ! adaptive immune response GO:0002250 94 64 0,000 0,21534824 0,22452446 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! appendage development GO:0048736 94 65 0,000 0,21832143 0,2275212 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,21832143 0,22741815 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,21832143 0,2273152 ! defense response to bacterium GO:0042742 73 65 0,000 0,21832143 0,22721235 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,21832143 0,22710958 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,21832143 0,22700691 ! activation of immune response GO:0002253 83 65 0,000 0,21832143 0,22690433 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,22128352 0,229879 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,22128352 0,22977521 ! antigen processing and presentation GO:0019882 96 66 0,000 0,22128352 0,22967153 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,22128352 0,22956793 ! regulation of immune effector process GO:0002697 101 66 0,000 0,22128352 0,22946443 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,22423456 0,23241978 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,22423456 0,23231508 ! acute inflammatory response GO:0002526 92 68 0,000 0,22717458 0,23525508 ! learning or memory GO:0007611 123 68 0,000 0,22717458 0,23514921 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,22717458 0,23504343 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,22717458 0,23493774 ! rhythmic process GO:0048511 105 68 0,000 0,22717458 0,23483215 ! inorganic anion transport GO:0015698 93 68 0,000 0,22717458 0,23472666 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,23010363 0,23764632 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,23010363 0,23753966 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,23010363 0,23743309 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,23302175 0,24033633 ! humoral immune response GO:0006959 86 70 0,000 0,23302175 0,24022861 ! eye development GO:0001654 111 70 0,000 0,23302175 0,24012098 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,23302175 0,24001345 ! muscle cell differentiation GO:0042692 104 71 0,000 0,23592897 0,24289912 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,23592897 0,24279044 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,23592897 0,24268186 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,23592897 0,24257337 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,23592897 0,24246499 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,23882534 0,24533197 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,23882534 0,24522245 ! regulation of blood pressure GO:0008217 107 73 0,000 0,2417109 0,24807455 ! tube morphogenesis GO:0035239 118 73 0,000 0,2417109 0,2479639 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,2417109 0,24785335 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,24458568 0,25068942 ! digestion GO:0007586 97 74 0,000 0,24458568 0,25057776 ! blood coagulation GO:0007596 116 75 0,000 0,24744973 0,2533991 GO:0050817|coagulation, ! regulation of ligase activity GO:0051340 114 75 0,000 0,24744973 0,25328633 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,24744973 0,25317365 ! amine biosynthetic process GO:0009309 97 76 0,000 0,25030308 0,25597914 ! tRNA metabolic process GO:0006399 95 76 0,000 0,25030308 0,25586537 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,25030308 0,2557517 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,25314578 0,25854143 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,25314578 0,25842667 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,25314578 0,25831202 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,25314578 0,25819747 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,25597786 0,26097034 ! cellular respiration GO:0045333 107 79 0,000 0,25879937 0,26372997 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,25879937 0,26361317 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,25879937 0,26349648 ! chromatin assembly GO:0031497 102 80 0,000 0,26161033 0,2662406 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,26161033 0,26612285 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,26161033 0,2660052 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,26161033 0,26588765 ! forebrain development GO:0030900 131 80 0,000 0,26161033 0,26577021 ! hemostasis GO:0007599 125 81 0,000 0,2644108 0,26849662 ! vitamin metabolic process GO:0006766 103 81 0,000 0,2644108 0,26837813 ! detection of stimulus GO:0051606 108 82 0,000 0,2672008 0,27109036 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,26998039 0,27378963 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,27274959 0,276476 ! sterol metabolic process GO:0016125 120 84 0,000 0,27274959 0,27635421 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,27550844 0,2790266 ! rRNA metabolic process GO:0016072 107 85 0,000 0,27550844 0,27890379 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,27550844 0,27878109 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,27550844 0,27865849 ! nucleosome organization GO:0034728 114 87 0,000 0,28099526 0,28408312 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,28099526 0,2839583 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,28099526 0,2838336 ! female pregnancy GO:0007565 130 87 0,000 0,28099526 0,283709 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,28099526 0,28358451 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,2837233 0,2862121 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,2837233 0,28608663 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,2837233 0,28596126 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,28644115 0,28857409 ! hormone metabolic process GO:0042445 121 90 0,000 0,28914884 0,2911744 ! ATP metabolic process GO:0046034 137 91 0,000 0,29184642 0,29376226 ! response to virus GO:0009615 122 91 0,000 0,29184642 0,29363375 ! positive regulation of immune response GO:0050778 121 92 0,000 0,29453391 0,29620813 ! sulfur metabolic process GO:0006790 118 92 0,000 0,29453391 0,29607866 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,29721135 0,29863963 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,29721135 0,29850922 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,29721135 0,29837892 ! electron transport chain GO:0022900 123 94 0,000 0,29987879 0,30092548 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,30518378 0,30611544 ! protein maturation GO:0051604 129 96 0,000 0,30518378 0,305982 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,30782141 0,30849205 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,31306713 0,31361254 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,31567528 0,31608757 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,31567528 0,31595002 ! divalent metal ion transport GO:0070838 171 100 0,000 0,31567528 0,31581259 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,31567528 0,31567528