pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6376-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! protein amino acid autophosphorylation GO:0046777 28 28 5,000 1,335E-10 2,46E-07 ! positive regulation of cell migration GO:0030335 36 36 4,000 5,631E-08 5,189E-05 ! positive regulation of cell motion GO:0051272 39 39 4,000 8,55E-08 5,252E-05 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 3,000 2,414E-07 1,112E-04 ! positive regulation of MAP kinase activity GO:0043406 50 49 4,000 2,777E-07 1,024E-04 ! peptidyl-tyrosine modification GO:0018212 21 20 3,000 3,012E-07 9,251E-05 ! peptidyl-amino acid modification GO:0018193 61 59 4,000 7,15E-07 1,883E-04 ! regulation of MAP kinase activity GO:0043405 67 66 4,000 1,259E-06 2,901E-04 ! regulation of cell migration GO:0030334 71 71 4,000 1,817E-06 3,72E-04 ! regulation of DNA replication GO:0006275 32 31 3,000 1,914E-06 3,527E-04 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 2,000 2,035E-06 3,41E-04 ! regulation of locomotion GO:0040012 79 79 4,000 3,096E-06 4,755E-04 ! regulation of cell motion GO:0051270 79 79 4,000 3,096E-06 4,389E-04 ! lung development GO:0030324 38 37 3,000 3,97E-06 5,226E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 2,000 3,982E-06 4,892E-04 ! positive regulation of protein kinase activity GO:0045860 89 86 4,000 4,719E-06 5,436E-04 ! respiratory tube development GO:0030323 40 39 3,000 4,924E-06 5,338E-04 ! respiratory system development GO:0060541 40 39 3,000 4,924E-06 5,042E-04 ! positive regulation of transferase activity GO:0051347 91 88 4,000 5,288E-06 5,129E-04 GO:0033674|positive regulation of kinase activity, ! positive regulation of DNA replication GO:0045740 14 13 2,000 6,875E-06 6,335E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 2,000 6,875E-06 6,033E-04 ! protein tetramerization GO:0051262 13 13 2,000 6,875E-06 5,759E-04 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 8,733E-06 6,997E-04 ! regulation of catabolic process GO:0009894 48 47 3,000 1,051E-05 8,071E-04 ! positive regulation of catabolic process GO:0009896 16 16 2,000 1,338E-05 9,865E-04 ! regulation of DNA metabolic process GO:0051052 51 50 3,000 1,349E-05 9,562E-04 ! regulation of fibroblast proliferation GO:0048145 17 17 2,000 1,622E-05 1,107E-03 ! negative regulation of protein transport GO:0051224 21 21 2,000 3,147E-05 2,072E-03 ! positive regulation of DNA metabolic process GO:0051054 23 22 2,000 3,637E-05 2,311E-03 ! response to radiation GO:0009314 70 68 3,000 4,603E-05 2,828E-03 ! regulation of gene-specific transcription GO:0032583 25 25 2,000 5,4E-05 3,21E-03 ! regulation of intracellular protein transport GO:0033157 25 25 2,000 5,4E-05 3,11E-03 ! positive regulation of hydrolase activity GO:0051345 72 72 3,000 5,769E-05 3,222E-03 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 2,000 6,84E-05 3,708E-03 ! regulation of epithelial cell proliferation GO:0050678 29 29 2,000 8,512E-05 4,482E-03 ! response to UV GO:0009411 29 29 2,000 8,512E-05 4,357E-03 ! positive regulation of glucose metabolic process GO:0010907 5 5 1,000 8,825E-05 4,396E-03 ! dopamine receptor signaling pathway GO:0007212 5 5 1,000 8,825E-05 4,28E-03 ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 8,825E-05 4,171E-03 ! receptor clustering GO:0043113 5 5 1,000 8,825E-05 4,066E-03 ! actin cytoskeleton reorganization GO:0031532 5 5 1,000 8,825E-05 3,967E-03 ! protein heterooligomerization GO:0051291 5 5 1,000 8,825E-05 3,873E-03 ! T cell lineage commitment GO:0002360 5 5 1,000 8,825E-05 3,783E-03 ! peptidyl-lysine modification GO:0018205 5 5 1,000 8,825E-05 3,697E-03 ! negative regulation of neuroblast proliferation GO:0007406 5 5 1,000 8,825E-05 3,614E-03 ! male genitalia development GO:0030539 5 5 1,000 8,825E-05 3,536E-03 ! tube development GO:0035295 83 81 3,000 9,164E-05 3,593E-03 ! regulation of intracellular transport GO:0032386 31 31 2,000 1,043E-04 4,005E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 2,000 1,149E-04 4,32E-03 ! heart development GO:0007507 90 87 3,000 1,212E-04 4,466E-03 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 1,321E-04 4,775E-03 GO:0018409|peptide or protein amino-terminal blocking, ! virus-host interaction GO:0019048 6 6 1,000 1,321E-04 4,683E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 1,000 1,321E-04 4,595E-03 ! ER overload response GO:0006983 6 6 1,000 1,321E-04 4,51E-03 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 1,321E-04 4,428E-03 GO:0070667|negative regulation of mast cell proliferation, ! G1 DNA damage checkpoint GO:0031571 6 6 1,000 1,321E-04 4,349E-03 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 1,321E-04 4,272E-03 ! genitalia development GO:0048806 6 6 1,000 1,321E-04 4,199E-03 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 1,321E-04 4,128E-03 ! nitric oxide metabolic process GO:0046209 6 6 1,000 1,321E-04 4,059E-03 GO:0006809|nitric oxide biosynthetic process, ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 1,000 1,321E-04 3,992E-03 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! regulation of embryonic development GO:0045995 6 6 1,000 1,321E-04 3,928E-03 ! localization within membrane GO:0051668 6 6 1,000 1,321E-04 3,866E-03 ! regulation of protein catabolic process GO:0042176 35 34 2,000 1,38E-04 3,975E-03 ! regulation of transcription factor activity GO:0051090 38 37 2,000 1,782E-04 5,052E-03 GO:0090046|regulation of transcription regulator activity, ! positive regulation of cellular catabolic process GO:0031331 7 7 1,000 1,847E-04 5,156E-03 ! regulation of mRNA processing GO:0050684 7 7 1,000 1,847E-04 5,079E-03 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 1,847E-04 5,005E-03 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! response to X-ray GO:0010165 7 7 1,000 1,847E-04 4,932E-03 ! regulation of intracellular pH GO:0051453 7 7 1,000 1,847E-04 4,862E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 1,000 1,847E-04 4,793E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! induction of an organ GO:0001759 7 7 1,000 1,847E-04 4,727E-03 ! response to gamma radiation GO:0010332 8 7 1,000 1,847E-04 4,662E-03 ! synaptic transmission, cholinergic GO:0007271 7 7 1,000 1,847E-04 4,599E-03 ! regulation of ATPase activity GO:0043462 7 7 1,000 1,847E-04 4,538E-03 ! negative regulation of T cell activation GO:0050868 7 7 1,000 1,847E-04 4,478E-03 ! protein oligomerization GO:0051259 39 39 2,000 2,087E-04 4,996E-03 ! dicarboxylic acid transport GO:0006835 8 8 1,000 2,457E-04 5,807E-03 ! cell-cell junction assembly GO:0007043 8 8 1,000 2,457E-04 5,733E-03 ! sex determination GO:0007530 8 8 1,000 2,457E-04 5,661E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 1,000 2,457E-04 5,592E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 1,000 2,457E-04 5,523E-03 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 2,457E-04 5,457E-03 ! developmental induction GO:0031128 8 8 1,000 2,457E-04 5,392E-03 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 8 8 1,000 2,457E-04 5,328E-03 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 1,000 3,154E-04 6,759E-03 ! pigmentation during development GO:0048066 9 9 1,000 3,154E-04 6,681E-03 ! L-glutamate transport GO:0015813 9 9 1,000 3,154E-04 6,605E-03 GO:0015800|acidic amino acid transport, ! positive regulation of protein import into nucleus GO:0042307 9 9 1,000 3,154E-04 6,531E-03 ! regulation of cellular pH GO:0030641 9 9 1,000 3,154E-04 6,458E-03 ! histone acetylation GO:0016573 9 9 1,000 3,154E-04 6,387E-03 ! regulation of calcium-mediated signaling GO:0050848 9 9 1,000 3,154E-04 6,318E-03 ! regulation of DNA binding GO:0051101 47 45 2,000 3,203E-04 6,348E-03 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 1,000 3,935E-04 7,715E-03 ! regulation of glucose metabolic process GO:0010906 10 10 1,000 3,935E-04 7,634E-03 ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 1,000 3,935E-04 7,554E-03 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 3,935E-04 7,477E-03 ! neuromuscular junction development GO:0007528 10 10 1,000 3,935E-04 7,4E-03 ! positive regulation of neuron apoptosis GO:0043525 10 10 1,000 3,935E-04 7,325E-03 ! protein stabilization GO:0050821 10 10 1,000 3,935E-04 7,252E-03 ! cell cycle arrest GO:0007050 49 49 2,000 4,126E-04 7,53E-03 ! skeletal muscle tissue development GO:0007519 50 49 2,000 4,126E-04 7,456E-03 GO:0060538|skeletal muscle organ development, ! negative regulation of transport GO:0051051 51 50 2,000 4,381E-04 7,839E-03 ! signal complex assembly GO:0007172 11 11 1,000 4,801E-04 8,507E-03 ! protein amino acid acetylation GO:0006473 11 11 1,000 4,801E-04 8,426E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 1,000 4,801E-04 8,347E-03 GO:0032388|positive regulation of intracellular transport, ! cellular response to starvation GO:0009267 11 11 1,000 4,801E-04 8,269E-03 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 1,000 4,801E-04 8,192E-03 ! G1/S transition checkpoint GO:0031575 12 11 1,000 4,801E-04 8,117E-03 ! interaction with host GO:0051701 11 11 1,000 4,801E-04 8,043E-03 ! regulation of monooxygenase activity GO:0032768 11 11 1,000 4,801E-04 7,971E-03 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 1,000 4,801E-04 7,9E-03 GO:0006109|regulation of carbohydrate metabolic process, ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 4,801E-04 7,83E-03 ! cell fate commitment GO:0045165 52 52 2,000 4,921E-04 7,955E-03 ! response to light stimulus GO:0009416 53 52 2,000 4,921E-04 7,886E-03 ! regulation of protein transport GO:0051223 53 53 2,000 5,206E-04 8,271E-03 GO:0070201|regulation of establishment of protein localization, ! positive regulation of protein catabolic process GO:0045732 12 12 1,000 5,75E-04 9,058E-03 ! xenobiotic metabolic process GO:0006805 12 12 1,000 5,75E-04 8,981E-03 ! mitotic chromosome condensation GO:0007076 12 12 1,000 5,75E-04 8,905E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 1,000 5,75E-04 8,831E-03 ! somitogenesis GO:0001756 13 12 1,000 5,75E-04 8,758E-03 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 1,000 5,75E-04 8,686E-03 ! reproductive developmental process GO:0003006 56 56 2,000 6,124E-04 9,176E-03 ! extracellular structure organization GO:0043062 56 56 2,000 6,124E-04 9,102E-03 ! regulation of protein localization GO:0032880 58 57 2,000 6,451E-04 9,512E-03 ! regulation of binding GO:0051098 60 57 2,000 6,451E-04 9,436E-03 ! mitochondrial membrane organization GO:0007006 13 13 1,000 6,783E-04 9,844E-03 ! negative regulation of DNA replication GO:0008156 13 13 1,000 6,783E-04 9,767E-03 ! receptor metabolic process GO:0043112 14 13 1,000 6,783E-04 9,691E-03 ! negative regulation of protein catabolic process GO:0042177 13 13 1,000 6,783E-04 9,616E-03 ! cell aging GO:0007569 13 13 1,000 6,783E-04 9,543E-03 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 1,000 6,783E-04 9,471E-03 ! response to endoplasmic reticulum stress GO:0034976 13 13 1,000 6,783E-04 9,399E-03 ! negative regulation of intracellular transport GO:0032387 13 13 1,000 6,783E-04 9,329E-03 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 6,783E-04 9,26E-03 ! cell-cell junction organization GO:0045216 13 13 1,000 6,783E-04 9,192E-03 ! tissue homeostasis GO:0001894 13 13 1,000 6,783E-04 9,125E-03 GO:0048871|multicellular organismal homeostasis, ! regulation of protein amino acid phosphorylation GO:0001932 62 61 2,000 7,873E-04 0,01051435 ! protein amino acid acylation GO:0043543 14 14 1,000 7,899E-04 0,01047339 ! base-excision repair GO:0006284 14 14 1,000 7,899E-04 0,01039858 ! protein import into nucleus, translocation GO:0000060 15 15 1,000 9,098E-04 0,01189136 ! positive regulation of fibroblast proliferation GO:0048146 15 15 1,000 9,098E-04 0,01180762 ! regulation of transcription factor import into nucleus GO:0042990 15 15 1,000 9,098E-04 0,01172505 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 1,000 9,098E-04 0,01164363 ! insulin receptor signaling pathway GO:0008286 17 15 1,000 9,098E-04 0,01156333 ! ER-nuclear signaling pathway GO:0006984 15 15 1,000 9,098E-04 0,01148412 ! chromosome condensation GO:0030261 15 15 1,000 9,098E-04 0,011406 ! response to starvation GO:0042594 15 15 1,000 9,098E-04 0,01132893 ! response to ionizing radiation GO:0010212 16 15 1,000 9,098E-04 0,0112529 ! negative regulation of transcription factor activity GO:0043433 16 15 1,000 9,098E-04 0,01117788 GO:0090048|negative regulation of transcription regulator activity, ! negative regulation of cell activation GO:0050866 15 15 1,000 9,098E-04 0,01110386 ! striated muscle tissue development GO:0014706 69 67 2,000 1,036E-03 0,01255747 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 1,000 1,038E-03 0,01250121 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 1,000 1,038E-03 0,01242003 ! segmentation GO:0035282 17 16 1,000 1,038E-03 0,0123399 ! cell fate specification GO:0001708 16 16 1,000 1,038E-03 0,0122608 ! cellular response to nutrient levels GO:0031669 16 16 1,000 1,038E-03 0,01218271 ! response to xenobiotic stimulus GO:0009410 16 16 1,000 1,038E-03 0,0121056 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 1,174E-03 0,01360833 ! myelination GO:0042552 17 17 1,000 1,174E-03 0,01352328 ! cell junction assembly GO:0034329 18 17 1,000 1,174E-03 0,01343928 ! development of primary male sexual characteristics GO:0046546 17 17 1,000 1,174E-03 0,01335632 ! response to toxin GO:0009636 18 17 1,000 1,174E-03 0,01327438 ! negative regulation of cell development GO:0010721 18 17 1,000 1,174E-03 0,01319344 GO:0050768|negative regulation of neurogenesis, ! regulation of oxidoreductase activity GO:0051341 17 17 1,000 1,174E-03 0,01311348 ! pigmentation GO:0043473 17 17 1,000 1,174E-03 0,01303448 ! muscle tissue development GO:0060537 72 70 2,000 1,176E-03 0,01298363 ! regulation of cellular catabolic process GO:0031329 18 18 1,000 1,318E-03 0,01446259 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 1,000 1,318E-03 0,01437701 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 1,000 1,318E-03 0,01429244 ! negative regulation of DNA binding GO:0043392 19 18 1,000 1,318E-03 0,01420886 ! B cell differentiation GO:0030183 18 18 1,000 1,318E-03 0,01412625 ! cellular response to extracellular stimulus GO:0031668 18 18 1,000 1,318E-03 0,0140446 ! ensheathment of neurons GO:0007272 18 18 1,000 1,318E-03 0,01396388 GO:0008366|axon ensheathment, ! negative regulation of catabolic process GO:0009895 18 18 1,000 1,318E-03 0,01388409 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 1,000 1,318E-03 0,0138052 ! DNA damage checkpoint GO:0000077 19 19 1,000 1,471E-03 0,01531397 ! negative regulation of DNA metabolic process GO:0051053 19 19 1,000 1,471E-03 0,01522794 ! regulation of pH GO:0006885 19 19 1,000 1,471E-03 0,01514287 ! peripheral nervous system development GO:0007422 19 19 1,000 1,471E-03 0,01505874 ! regulation of protein stability GO:0031647 19 19 1,000 1,471E-03 0,01497554 ! response to heat GO:0009408 19 19 1,000 1,471E-03 0,01489326 ! regulation of protein modification process GO:0031399 79 78 2,000 1,61E-03 0,01621012 ! negative regulation of binding GO:0051100 21 20 1,000 1,631E-03 0,01633811 ! positive regulation of gene-specific transcription GO:0043193 20 20 1,000 1,631E-03 0,0162498 ! mitotic sister chromatid segregation GO:0000070 21 21 1,000 1,8E-03 0,01783092 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 1,000 1,8E-03 0,01773557 ! mammary gland development GO:0030879 23 21 1,000 1,8E-03 0,01764123 ! organic anion transport GO:0015711 21 21 1,000 1,8E-03 0,01754789 ! DNA integrity checkpoint GO:0031570 21 21 1,000 1,8E-03 0,01745553 ! regulation of protein import into nucleus GO:0042306 21 21 1,000 1,8E-03 0,01736414 ! regulation of action potential in neuron GO:0019228 21 21 1,000 1,8E-03 0,0172737 ! negative regulation of hydrolase activity GO:0051346 21 21 1,000 1,8E-03 0,0171842 ! cellular response to insulin stimulus GO:0032869 23 21 1,000 1,8E-03 0,01709562 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 1,976E-03 0,01867437 GO:0090047|positive regulation of transcription regulator activity, ! sister chromatid segregation GO:0000819 22 22 1,000 1,976E-03 0,0185791 ! odontogenesis GO:0042476 22 22 1,000 1,976E-03 0,01848479 ! cell junction organization GO:0034330 23 22 1,000 1,976E-03 0,01839143 ! maintenance of protein location in cell GO:0032507 23 22 1,000 1,976E-03 0,01829901 ! male sex differentiation GO:0046661 22 22 1,000 1,976E-03 0,01820752 ! regulation of cellular localization GO:0060341 86 85 2,000 2,061E-03 0,01889966 ! mitotic cell cycle checkpoint GO:0007093 24 23 1,000 2,16E-03 0,01970785 ! positive regulation of growth GO:0045927 23 23 1,000 2,16E-03 0,01961077 ! monovalent inorganic cation homeostasis GO:0055067 23 23 1,000 2,16E-03 0,01951464 ! calcium-mediated signaling GO:0019722 23 23 1,000 2,16E-03 0,01941944 ! cell projection assembly GO:0030031 25 23 1,000 2,16E-03 0,01932518 ! mitochondrial transport GO:0006839 24 24 1,000 2,352E-03 0,02094163 ! regulation of action potential GO:0001508 24 24 1,000 2,352E-03 0,02084095 ! glucose homeostasis GO:0042593 24 24 1,000 2,352E-03 0,02074123 GO:0033500|carbohydrate homeostasis, ! T cell differentiation GO:0030217 24 24 1,000 2,352E-03 0,02064246 ! maintenance of protein location GO:0045185 25 24 1,000 2,352E-03 0,02054463 ! negative regulation of cell cycle GO:0045786 92 91 2,000 2,506E-03 0,0217821 ! positive regulation of DNA binding GO:0043388 26 25 1,000 2,552E-03 0,02208081 ! endosome transport GO:0016197 25 25 1,000 2,552E-03 0,02197763 ! regulation of T cell proliferation GO:0042129 25 25 1,000 2,552E-03 0,02187541 ! heart morphogenesis GO:0003007 25 25 1,000 2,552E-03 0,02177413 ! negative regulation of immune system process GO:0002683 25 25 1,000 2,552E-03 0,02167379 ! positive regulation of binding GO:0051099 27 26 1,000 2,76E-03 0,02332931 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 1,000 2,76E-03 0,02322278 ! induction of apoptosis by intracellular signals GO:0008629 26 26 1,000 2,76E-03 0,02311723 ! regulation of T cell differentiation GO:0045580 26 26 1,000 2,76E-03 0,02301262 ! double-strand break repair GO:0006302 27 26 1,000 2,76E-03 0,02290896 ! response to insulin stimulus GO:0032868 28 26 1,000 2,76E-03 0,02280623 ! maintenance of location in cell GO:0051651 27 26 1,000 2,76E-03 0,02270442 ! synapse organization GO:0050808 26 26 1,000 2,76E-03 0,02260351 ! cAMP-mediated signaling GO:0019933 27 27 1,000 2,975E-03 0,02425915 ! peptide metabolic process GO:0006518 29 27 1,000 2,975E-03 0,02415228 ! activation of caspase activity GO:0006919 27 27 1,000 2,975E-03 0,02404635 ! posttranscriptional regulation of gene expression GO:0010608 98 98 2,000 3,094E-03 0,02490189 ! histone modification GO:0016570 28 28 1,000 3,198E-03 0,02562376 ! regulation of mast cell proliferation GO:0070666 28 28 1,000 3,198E-03 0,02551283 ! muscle organ development GO:0007517 102 100 2,000 3,277E-03 0,02602966 ! hemopoiesis GO:0030097 104 100 2,000 3,277E-03 0,02591795 ! positive regulation of cell cycle GO:0045787 29 29 1,000 3,428E-03 0,0270017 ! viral reproductive process GO:0022415 29 29 1,000 3,428E-03 0,02688679 ! regulation of lymphocyte proliferation GO:0050670 29 29 1,000 3,428E-03 0,02677287 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! covalent chromatin modification GO:0016569 29 29 1,000 3,428E-03 0,0266599 ! positive regulation of protein transport GO:0051222 29 29 1,000 3,428E-03 0,02654789 ! positive regulation of peptidase activity GO:0010952 30 30 1,000 3,666E-03 0,02827316 GO:0043280|positive regulation of caspase activity, ! activation of phospholipase C activity GO:0007202 30 30 1,000 3,666E-03 0,02815536 GO:0010863|positive regulation of phospholipase C activity, ! response to temperature stimulus GO:0009266 30 30 1,000 3,666E-03 0,02803853 ! skeletal muscle fiber development GO:0048741 31 31 1,000 3,912E-03 0,02979359 ! B cell activation GO:0042113 31 31 1,000 3,912E-03 0,02967098 ! aging GO:0007568 32 31 1,000 3,912E-03 0,02954938 ! regulation of translational initiation GO:0006446 31 31 1,000 3,912E-03 0,02942877 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 3,912E-03 0,02930914 ! extracellular matrix organization GO:0030198 31 31 1,000 3,912E-03 0,02919048 ! negative regulation of cell growth GO:0030308 32 32 1,000 4,165E-03 0,03095406 ! muscle fiber development GO:0048747 32 32 1,000 4,165E-03 0,03082974 ! regulation of phospholipase activity GO:0010517 32 32 1,000 4,165E-03 0,03070642 ! regulation of lymphocyte differentiation GO:0045619 32 32 1,000 4,165E-03 0,03058409 ! positive regulation of lipase activity GO:0060193 32 32 1,000 4,165E-03 0,03046272 ! maintenance of location GO:0051235 33 32 1,000 4,165E-03 0,03034232 ! negative regulation of cell size GO:0045792 33 33 1,000 4,426E-03 0,03211369 ! amino acid transport GO:0006865 33 33 1,000 4,426E-03 0,03198776 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 4,426E-03 0,0318628 ! regulation of angiogenesis GO:0045765 35 34 1,000 4,694E-03 0,03366064 ! response to peptide hormone stimulus GO:0043434 36 34 1,000 4,694E-03 0,03353017 ! viral reproduction GO:0016032 34 34 1,000 4,694E-03 0,03340071 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 1,000 4,969E-03 0,03522401 ! positive regulation of phosphorylation GO:0042327 35 35 1,000 4,969E-03 0,03508906 ! positive regulation of phosphorus metabolic process GO:0010562 36 36 1,000 5,252E-03 0,03694343 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of lipase activity GO:0060191 36 36 1,000 5,252E-03 0,03680296 ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 5,542E-03 0,03868754 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! response to drug GO:0042493 37 37 1,000 5,542E-03 0,03854155 ! negative regulation of growth GO:0045926 37 37 1,000 5,542E-03 0,03839666 ! DNA damage response, signal transduction GO:0042770 37 37 1,000 5,542E-03 0,03825285 ! axon guidance GO:0007411 39 38 1,000 5,839E-03 0,04015358 ! chromosome segregation GO:0007059 38 38 1,000 5,839E-03 0,04000431 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 6,143E-03 0,04193352 ! activation of MAPK activity GO:0000187 39 39 1,000 6,143E-03 0,04177878 ! response to unfolded protein GO:0006986 39 39 1,000 6,143E-03 0,04162518 ! nucleotide-excision repair GO:0006289 40 39 1,000 6,143E-03 0,04147271 ! cytokine-mediated signaling pathway GO:0019221 39 39 1,000 6,143E-03 0,04132135 ! intracellular protein transmembrane transport GO:0065002 39 39 1,000 6,143E-03 0,04117109 ! lymphocyte differentiation GO:0030098 39 39 1,000 6,143E-03 0,04102192 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 6,455E-03 0,04294621 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 6,773E-03 0,04490372 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! cell cycle checkpoint GO:0000075 42 41 1,000 6,773E-03 0,04474277 ! regulation of caspase activity GO:0043281 41 41 1,000 6,773E-03 0,04458298 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 7,099E-03 0,04656005 ! regulation of endopeptidase activity GO:0052548 42 42 1,000 7,099E-03 0,04639495 ! development of primary sexual characteristics GO:0045137 42 42 1,000 7,099E-03 0,04623101 ! protein ubiquitination GO:0016567 43 42 1,000 7,099E-03 0,04606822 ! response to protein stimulus GO:0051789 42 42 1,000 7,099E-03 0,04590658 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 1,000 7,432E-03 0,04788967 ! mitochondrion organization GO:0007005 44 43 1,000 7,432E-03 0,0477228 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 7,432E-03 0,0475571 ! mRNA transport GO:0051028 44 44 1,000 7,771E-03 0,04955836 ! protein import into nucleus GO:0006606 44 44 1,000 7,771E-03 0,04938747 ! phosphoinositide-mediated signaling GO:0048015 45 45 1,000 8,118E-03 0,0514126 ! nuclear import GO:0051170 45 45 1,000 8,118E-03 0,05123653 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 1,000 8,471E-03 0,05328486 ! regulation of peptidase activity GO:0052547 46 46 1,000 8,471E-03 0,05310362 ! cellular response to hormone stimulus GO:0032870 48 46 1,000 8,471E-03 0,05292361 ! regulation of membrane potential GO:0042391 46 46 1,000 8,471E-03 0,05274481 ! sex differentiation GO:0007548 47 47 1,000 8,832E-03 0,05480299 ! amine transport GO:0015837 47 47 1,000 8,832E-03 0,05461909 ! actin filament organization GO:0007015 50 48 1,000 9,199E-03 0,0566992 ! protein localization in nucleus GO:0034504 48 48 1,000 9,199E-03 0,0565102 ! leukocyte differentiation GO:0002521 50 49 1,000 9,572E-03 0,05861165 ! ossification GO:0001503 50 49 1,000 9,572E-03 0,05841757 GO:0060348|bone development, ! gland development GO:0048732 51 49 1,000 9,572E-03 0,05822477 ! RNA transport GO:0050658 50 50 1,000 9,953E-03 0,06034062 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! T cell activation GO:0042110 51 50 1,000 9,953E-03 0,06014279 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 1,000 9,953E-03 0,05994624 ! regulation of neurogenesis GO:0050767 51 50 1,000 9,953E-03 0,05975098 ! anatomical structure homeostasis GO:0060249 51 50 1,000 9,953E-03 0,05955698 ! anterior/posterior pattern formation GO:0009952 51 50 1,000 9,953E-03 0,05936424 ! protein modification by small protein conjugation GO:0032446 52 51 1,000 0,01034038 0,06147522 ! interphase of mitotic cell cycle GO:0051329 52 51 1,000 0,01034038 0,06127755 GO:0051325|interphase, ! RNA localization GO:0006403 52 52 1,000 0,01073431 0,06340813 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 1,000 0,01073431 0,06320555 ! response to hypoxia GO:0001666 53 53 1,000 0,01113485 0,06535519 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 1,000 0,01113485 0,06514771 ! regulation of T cell activation GO:0050863 53 53 1,000 0,01113485 0,06494155 ! response to oxygen levels GO:0070482 55 54 1,000 0,01154196 0,06710355 ! in utero embryonic development GO:0001701 55 55 1,000 0,01195559 0,06928978 ! regulation of cell adhesion GO:0030155 56 55 1,000 0,01195559 0,06907257 ! protein modification by small protein conjugation or removal GO:0070647 56 55 1,000 0,01195559 0,06885672 ! regulation of nervous system development GO:0051960 57 56 1,000 0,01237571 0,0710543 ! carboxylic acid transport GO:0046942 59 59 1,000 0,01367459 0,07826794 GO:0015849|organic acid transport, ! regulation of cell development GO:0060284 60 59 1,000 0,01367459 0,07802562 ! protein localization in organelle GO:0033365 59 59 1,000 0,01367459 0,0777848 ! axonogenesis GO:0007409 66 62 1,000 0,01503045 0,08523422 ! protein import GO:0017038 62 62 1,000 0,01503045 0,08497276 ! regulation of lymphocyte activation GO:0051249 62 62 1,000 0,01503045 0,08471291 ! rRNA transcription GO:0009303 5 5 0,000 0,01517313 0,08525633 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,01517313 0,0849972 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,01517313 0,08473963 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,01517313 0,08448362 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,01517313 0,08422915 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,01517313 0,08397621 ! reproductive cellular process GO:0048610 5 5 0,000 0,01517313 0,08372478 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,01517313 0,08347486 ! prostate gland development GO:0030850 5 5 0,000 0,01517313 0,08322642 ! metencephalon development GO:0022037 5 5 0,000 0,01517313 0,08297946 ! water transport GO:0006833 5 5 0,000 0,01517313 0,08273396 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,01517313 0,0824899 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,01517313 0,08224729 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,01517313 0,08200609 ! glycerol metabolic process GO:0006071 5 5 0,000 0,01517313 0,08176631 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,01517313 0,08152792 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,01517313 0,08129092 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,01517313 0,0810553 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,01517313 0,08082103 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,01517313 0,08058812 ! filopodium assembly GO:0046847 7 5 0,000 0,01517313 0,08035654 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,01517313 0,0801263 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,01517313 0,07989736 ! GTP metabolic process GO:0046039 5 5 0,000 0,01517313 0,07966974 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,01517313 0,0794434 ! mRNA stabilization GO:0048255 5 5 0,000 0,01517313 0,07921835 GO:0043489|RNA stabilization, ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,01517313 0,07899457 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,01517313 0,07877205 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,01517313 0,07855078 ! social behavior GO:0035176 5 5 0,000 0,01517313 0,07833075 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,01517313 0,07811195 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,01517313 0,07789437 ! memory GO:0007613 5 5 0,000 0,01517313 0,07767799 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,01517313 0,07746282 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,01517313 0,07724883 ! response to lipid GO:0033993 5 5 0,000 0,01517313 0,07703603 ! erythrocyte maturation GO:0043249 5 5 0,000 0,01517313 0,07682439 ! hippocampus development GO:0021766 6 5 0,000 0,01517313 0,07661391 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,01517313 0,07640458 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,01517313 0,0761964 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,01517313 0,07598934 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,01517313 0,07578341 ! mechanosensory behavior GO:0007638 5 5 0,000 0,01517313 0,07557859 ! heart looping GO:0001947 5 5 0,000 0,01517313 0,07537487 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,01517313 0,07517225 ! response to interferon-gamma GO:0034341 5 5 0,000 0,01517313 0,07497072 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,01517313 0,07477026 ! endocrine pancreas development GO:0031018 5 5 0,000 0,01517313 0,07457087 ! pH reduction GO:0045851 5 5 0,000 0,01517313 0,07437255 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,01517313 0,07417527 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,01517313 0,07397904 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,01517313 0,07378385 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,01517313 0,07358968 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,01517313 0,07339653 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,01517313 0,07320439 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,01517313 0,07301326 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,01517313 0,07282312 ! adrenal gland development GO:0030325 5 5 0,000 0,01517313 0,07263397 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,01517313 0,0724458 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,01517313 0,0722586 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,01517313 0,07207236 ! astrocyte differentiation GO:0048708 5 5 0,000 0,01517313 0,07188709 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,01517313 0,07170276 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,01517313 0,07151938 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,01517313 0,07133693 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,01517313 0,07115541 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,01517313 0,07097482 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,01517313 0,07079513 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,01517313 0,07061636 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,01517313 0,07043848 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,01517313 0,0702615 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,01517313 0,07008541 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,01517313 0,06991019 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,01517313 0,06973585 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,01517313 0,06956238 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,01517313 0,06938977 ! response to ATP GO:0033198 5 5 0,000 0,01517313 0,06921801 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,01517313 0,06904711 ! regulation of appetite GO:0032098 5 5 0,000 0,01517313 0,06887704 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,01517313 0,06870781 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,01517313 0,06853941 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,01517313 0,06837183 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,01517313 0,06820507 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01517313 0,06803912 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,01517313 0,06787397 ! fear response GO:0042596 5 5 0,000 0,01517313 0,06770963 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,01517313 0,06754608 ! retinol metabolic process GO:0042572 5 5 0,000 0,01517313 0,06738332 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,01517313 0,06722134 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,01517313 0,06706014 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,01517313 0,06689971 ! parturition GO:0007567 5 5 0,000 0,01517313 0,06674004 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,01517313 0,06658114 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 0,000 0,01517313 0,06642299 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,01517313 0,06626559 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,01517313 0,06610893 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,01517313 0,06595301 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,01517313 0,06579783 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,01517313 0,06564337 ! response to UV-B GO:0010224 5 5 0,000 0,01517313 0,06548964 ! oligodendrocyte development GO:0014003 5 5 0,000 0,01517313 0,06533663 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,01517313 0,06518433 ! activated T cell proliferation GO:0050798 5 5 0,000 0,01517313 0,06503274 ! interaction with symbiont GO:0051702 5 5 0,000 0,01517313 0,06488185 ! cellular extravasation GO:0045123 5 5 0,000 0,01517313 0,06473166 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,01517313 0,06458217 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,01517313 0,06443336 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,01517313 0,06428524 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,01517313 0,06413779 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,01517313 0,06399102 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,01517313 0,06384493 ! response to amine stimulus GO:0014075 5 5 0,000 0,01517313 0,06369949 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,01517313 0,06355472 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,01517313 0,06341061 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,01517313 0,06326714 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,01517313 0,06312433 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,01517313 0,06298216 ! neuron recognition GO:0008038 5 5 0,000 0,01517313 0,06284062 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,01517313 0,06269973 ! decidualization GO:0046697 5 5 0,000 0,01517313 0,06255946 ! hair follicle maturation GO:0048820 5 5 0,000 0,01517313 0,06241982 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,01517313 0,0622808 ! regulation of mitochondrial membrane potential GO:0051881 5 5 0,000 0,01517313 0,06214239 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,01517313 0,06200461 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,01517313 0,06186743 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,01517313 0,06173086 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,01517313 0,06159488 ! postreplication repair GO:0006301 5 5 0,000 0,01517313 0,06145951 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,01517313 0,06132473 GO:0021517|ventral spinal cord development, ! cellular pigmentation GO:0033059 5 5 0,000 0,01517313 0,06119054 ! histone methylation GO:0016571 5 5 0,000 0,01517313 0,06105694 ! DNA methylation GO:0006306 5 5 0,000 0,01517313 0,06092392 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01517313 0,06079147 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,01517313 0,0606596 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,01517313 0,06052831 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,01517313 0,06039758 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,01517313 0,06026741 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,01517313 0,0601378 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,01517313 0,06000875 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,01517313 0,05988025 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,01517313 0,0597523 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,01517313 0,0596249 ! sterol catabolic process GO:0016127 5 5 0,000 0,01517313 0,05949804 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,01517313 0,05937171 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,01517313 0,05924593 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,01517313 0,05912067 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,01517313 0,05899594 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,01517313 0,05887174 ! zymogen activation GO:0031638 5 5 0,000 0,01517313 0,05874806 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,01517313 0,0586249 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,01517313 0,05850225 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 0,01517313 0,05838012 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,01517313 0,05825849 ! nucleosome positioning GO:0016584 5 5 0,000 0,01517313 0,05813738 ! regulation of isotype switching GO:0045191 5 5 0,000 0,01517313 0,05801676 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,01517313 0,05789664 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,01517313 0,05777702 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,01517313 0,05765789 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,01517313 0,05753925 ! NADPH regeneration GO:0006740 5 5 0,000 0,01517313 0,0574211 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,01517313 0,05730344 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,01517313 0,05718625 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 0,01517313 0,05706955 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 0,01517313 0,05695331 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,01517313 0,05683756 ! sarcomere organization GO:0045214 5 5 0,000 0,01517313 0,05672227 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,01517313 0,05660744 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,01517313 0,05649309 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,01517313 0,05637919 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,01517313 0,05626575 GO:0045622|regulation of T-helper cell differentiation, ! oocyte differentiation GO:0009994 5 5 0,000 0,01517313 0,05615277 GO:0048599|oocyte development, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,01517313 0,05604024 ! regulation of protein homodimerization activity GO:0043496 6 5 0,000 0,01517313 0,05592816 ! spleen development GO:0048536 5 5 0,000 0,01517313 0,05581652 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,01517313 0,05570533 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,01517313 0,05559459 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,01517313 0,05548428 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,01517313 0,05537441 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,01517313 0,05526498 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,01517313 0,05515597 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,01517313 0,0550474 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,01517313 0,05493925 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,01517313 0,05483152 ! ATP catabolic process GO:0006200 5 5 0,000 0,01517313 0,05472422 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01517313 0,05461734 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,01517313 0,05451087 ! blastocyst formation GO:0001825 5 5 0,000 0,01517313 0,05440482 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,01517313 0,05429918 ! embryonic gut development GO:0048566 5 5 0,000 0,01517313 0,05419395 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,01517313 0,05408912 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,01517313 0,05398471 ! activation of innate immune response GO:0002218 5 5 0,000 0,01517313 0,05388069 GO:0002758|innate immune response-activating signal transduction, ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 0,000 0,01517313 0,05377707 ! catecholamine transport GO:0051937 5 5 0,000 0,01517313 0,05367385 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,01517313 0,05357103 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,01517313 0,0534686 ! muscle adaptation GO:0043500 5 5 0,000 0,01517313 0,05336656 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,01517313 0,05326491 ! embryonic heart tube development GO:0035050 5 5 0,000 0,01517313 0,05316365 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,01517313 0,05306277 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,01517313 0,05296227 ! defense response to fungus GO:0050832 5 5 0,000 0,01517313 0,05286215 ! lysogeny GO:0030069 5 5 0,000 0,01517313 0,05276241 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,01517313 0,05266305 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,01517313 0,05256406 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,01517313 0,05246544 ! response to nicotine GO:0035094 5 5 0,000 0,01517313 0,05236719 ! establishment of cell polarity GO:0030010 5 5 0,000 0,01517313 0,0522693 ! mitochondrion localization GO:0051646 5 5 0,000 0,01517313 0,05217179 ! nucleus localization GO:0051647 5 5 0,000 0,01517313 0,05207463 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,01517313 0,05197784 ! angiogenesis GO:0001525 65 64 1,000 0,01596549 0,05459072 ! positive regulation of protein metabolic process GO:0051247 64 64 1,000 0,01596549 0,05448963 ! anion transport GO:0006820 65 65 1,000 0,01644223 0,05601301 ! DNA packaging GO:0006323 66 66 1,000 0,01692508 0,05755151 ! negative regulation of protein metabolic process GO:0051248 66 66 1,000 0,01692508 0,05744552 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 1,000 0,01741398 0,05899627 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! negative regulation of cell differentiation GO:0045596 68 67 1,000 0,01741398 0,05888802 ! Ras protein signal transduction GO:0007265 69 67 1,000 0,01741398 0,05878017 ! regulation of cell size GO:0008361 68 68 1,000 0,01790891 0,06034026 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,01818133 0,06114633 ! axon extension GO:0048675 7 6 0,000 0,01818133 0,06103495 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,01818133 0,06092398 ! tRNA modification GO:0006400 6 6 0,000 0,01818133 0,06081341 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,01818133 0,06070324 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,01818133 0,06059347 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,01818133 0,06048409 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,01818133 0,06037511 ! regulation of S phase GO:0033261 6 6 0,000 0,01818133 0,06026652 ! myotube differentiation GO:0014902 6 6 0,000 0,01818133 0,06015833 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,01818133 0,06005051 ! bone remodeling GO:0046849 6 6 0,000 0,01818133 0,05994309 ! N-glycan processing GO:0006491 6 6 0,000 0,01818133 0,05983605 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,01818133 0,05972939 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,01818133 0,05962311 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,01818133 0,05951721 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,01818133 0,05941168 ! RNA methylation GO:0001510 6 6 0,000 0,01818133 0,05930653 ! cartilage condensation GO:0001502 7 6 0,000 0,01818133 0,05920174 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,01818133 0,05909733 ! regulation of positive chemotaxis GO:0050926 6 6 0,000 0,01818133 0,05899329 GO:0050927|positive regulation of positive chemotaxis, ! succinate metabolic process GO:0006105 7 6 0,000 0,01818133 0,05888961 ! artery development GO:0060840 6 6 0,000 0,01818133 0,05878629 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,01818133 0,05868334 ! bile acid metabolic process GO:0008206 6 6 0,000 0,01818133 0,05858075 ! androgen metabolic process GO:0008209 6 6 0,000 0,01818133 0,05847851 ! estrogen metabolic process GO:0008210 6 6 0,000 0,01818133 0,05837663 ! limbic system development GO:0021761 7 6 0,000 0,01818133 0,05827511 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,01818133 0,05817394 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,01818133 0,05807311 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,01818133 0,05797264 ! pathogenesis GO:0009405 6 6 0,000 0,01818133 0,05787252 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,01818133 0,05777274 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,01818133 0,0576733 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,01818133 0,0575742 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,01818133 0,05747545 ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,01818133 0,05737703 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,01818133 0,05727895 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,01818133 0,05718121 ! arginine metabolic process GO:0006525 6 6 0,000 0,01818133 0,05708379 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,01818133 0,05698671 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,01818133 0,05688996 ! glutamate catabolic process GO:0006538 7 6 0,000 0,01818133 0,05679354 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,01818133 0,05669744 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,01818133 0,05660167 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,01818133 0,05650622 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 0,01818133 0,05641109 ! V(D)J recombination GO:0033151 6 6 0,000 0,01818133 0,05631628 ! focal adhesion formation GO:0048041 7 6 0,000 0,01818133 0,05622179 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,01818133 0,05612762 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,01818133 0,05603376 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,01818133 0,05594021 ! regulation of heart rate GO:0002027 6 6 0,000 0,01818133 0,05584698 ! lipid digestion GO:0044241 6 6 0,000 0,01818133 0,05575406 ! asymmetric protein localization GO:0008105 6 6 0,000 0,01818133 0,05566144 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,01818133 0,05556913 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,01818133 0,05547713 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,01818133 0,05538543 ! regulation of vascular permeability GO:0043114 6 6 0,000 0,01818133 0,05529404 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,01818133 0,05520294 ! ruffle organization GO:0031529 6 6 0,000 0,01818133 0,05511215 ! peptidyl-serine phosphorylation GO:0018105 6 6 0,000 0,01818133 0,05502165 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,01818133 0,05493145 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,01818133 0,05484155 ! neutral amino acid transport GO:0015804 6 6 0,000 0,01818133 0,05475194 ! L-amino acid transport GO:0015807 6 6 0,000 0,01818133 0,05466262 ! bone mineralization GO:0030282 6 6 0,000 0,01818133 0,05457359 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,01818133 0,05448486 ! negative regulation of ossification GO:0030279 6 6 0,000 0,01818133 0,05439641 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,01818133 0,05430825 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of bone resorption GO:0045124 6 6 0,000 0,01818133 0,05422037 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,01818133 0,05413277 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,01818133 0,05404546 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,01818133 0,05395843 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,01818133 0,05387168 ! regulation of organ growth GO:0046620 6 6 0,000 0,01818133 0,05378521 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,01818133 0,05369902 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,01818133 0,0536131 ! response to dsRNA GO:0043331 6 6 0,000 0,01818133 0,05352746 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,01818133 0,05344208 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,01818133 0,05335699 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,01818133 0,05327216 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,01818133 0,0531876 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,01818133 0,05310331 ! multicellular organismal aging GO:0010259 6 6 0,000 0,01818133 0,05301928 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,01818133 0,05293552 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,01818133 0,05285203 ! erythrocyte development GO:0048821 6 6 0,000 0,01818133 0,0527688 ! renal water homeostasis GO:0003091 6 6 0,000 0,01818133 0,05268583 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,01818133 0,05260312 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,01818133 0,05252067 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,01818133 0,05243848 ! ribosome assembly GO:0042255 6 6 0,000 0,01818133 0,05235654 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,01818133 0,05227486 ! diencephalon development GO:0021536 6 6 0,000 0,01818133 0,05219344 ! fucose catabolic process GO:0019317 6 6 0,000 0,01818133 0,05211227 GO:0042355|L-fucose catabolic process, ! protein sumoylation GO:0016925 6 6 0,000 0,01818133 0,05203135 ! regulation of lipid transport GO:0032368 6 6 0,000 0,01818133 0,05195068 ! regulation of cell division GO:0051302 6 6 0,000 0,01818133 0,05187026 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,01818133 0,05179009 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,01818133 0,05171017 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,01818133 0,05163049 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,01818133 0,05155106 ! neuroblast proliferation GO:0007405 6 6 0,000 0,01818133 0,05147187 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,01818133 0,05139293 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,01818133 0,05131422 ! regulation of glucose transport GO:0010827 6 6 0,000 0,01818133 0,05123576 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,01818133 0,05115754 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,01818133 0,05107955 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,01818133 0,05100181 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 0,01818133 0,0509243 ! thymus development GO:0048538 6 6 0,000 0,01818133 0,05084702 ! lymph node development GO:0048535 6 6 0,000 0,01818133 0,05076998 ! organic cation transport GO:0015695 6 6 0,000 0,01818133 0,05069317 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,01818133 0,0506166 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,01818133 0,05054025 ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,01818133 0,05046414 ! sperm-egg recognition GO:0035036 7 6 0,000 0,01818133 0,05038825 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,01818133 0,05031259 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,01818133 0,05023716 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,01818133 0,05016196 ! alditol metabolic process GO:0019400 6 6 0,000 0,01818133 0,05008698 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,01818133 0,05001222 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,01818133 0,04993769 ! maternal placenta development GO:0001893 6 6 0,000 0,01818133 0,04986337 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,01818133 0,04978928 ! regulation of translation GO:0006417 69 69 1,000 0,01840983 0,05034022 ! regionalization GO:0003002 70 69 1,000 0,01840983 0,05026564 ! response to nutrient levels GO:0031667 69 69 1,000 0,01840983 0,05019128 ! regulation of leukocyte activation GO:0002694 69 69 1,000 0,01840983 0,05011715 ! regulation of mitotic cell cycle GO:0007346 72 69 1,000 0,01840983 0,05004323 ! positive regulation of transport GO:0051050 71 70 1,000 0,01891669 0,0513453 ! cell part morphogenesis GO:0032990 75 70 1,000 0,01891669 0,05126979 ! wound healing GO:0042060 74 70 1,000 0,01891669 0,0511945 ! calcium ion homeostasis GO:0055074 71 71 1,000 0,01942946 0,05250513 GO:0006874|cellular calcium ion homeostasis, ! regulation of cell activation GO:0050865 71 71 1,000 0,01942946 0,05242826 ! response to extracellular stimulus GO:0009991 72 72 1,000 0,01994811 0,05374908 ! respiratory burst GO:0045730 7 7 0,000 0,02118077 0,0569871 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,02118077 0,05690403 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 0,02118077 0,0568212 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,02118077 0,05673861 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,02118077 0,05665626 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,02118077 0,05657415 ! regulation of chemokine production GO:0032642 7 7 0,000 0,02118077 0,05649228 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,02118077 0,05641065 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,02118077 0,05632924 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,02118077 0,05624808 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,02118077 0,05616715 GO:0043241|protein complex disassembly, ! hair follicle morphogenesis GO:0031069 7 7 0,000 0,02118077 0,05608645 ! gene silencing by RNA GO:0031047 7 7 0,000 0,02118077 0,05600598 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,02118077 0,05592574 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,02118077 0,05584573 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,02118077 0,05576595 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,02118077 0,0556864 ! axis specification GO:0009798 7 7 0,000 0,02118077 0,05560707 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,02118077 0,05552797 ! visual behavior GO:0007632 7 7 0,000 0,02118077 0,0554491 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,02118077 0,05537045 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,02118077 0,05529202 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,02118077 0,05521381 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,02118077 0,05513583 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,02118077 0,05505806 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,02118077 0,05498052 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,02118077 0,05490319 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,02118077 0,05482608 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,02118077 0,05474918 ! digestive system development GO:0055123 7 7 0,000 0,02118077 0,0546725 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,02118077 0,05459604 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,02118077 0,05451979 ! protein targeting to ER GO:0045047 8 7 0,000 0,02118077 0,05444375 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,02118077 0,05436792 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,02118077 0,0542923 ! endoderm development GO:0007492 7 7 0,000 0,02118077 0,0542169 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,02118077 0,0541417 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,02118077 0,05406671 GO:0006688|glycosphingolipid biosynthetic process, ! response to hexose stimulus GO:0009746 7 7 0,000 0,02118077 0,05399193 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,02118077 0,05391736 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,02118077 0,05384299 ! regulation of skeletal muscle fiber development GO:0048742 7 7 0,000 0,02118077 0,05376882 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,02118077 0,05369486 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,02118077 0,05362111 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,02118077 0,05354755 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,02118077 0,0534742 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,02118077 0,05340105 ! UV protection GO:0009650 7 7 0,000 0,02118077 0,0533281 ! DNA integration GO:0015074 7 7 0,000 0,02118077 0,05325534 ! myofibril assembly GO:0030239 7 7 0,000 0,02118077 0,05318279 GO:0055002|striated muscle cell development, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,02118077 0,05311043 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,02118077 0,05303827 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,02118077 0,0529663 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,02118077 0,05289453 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,02118077 0,05282296 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,02118077 0,05275158 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,02118077 0,05268039 GO:0019827|stem cell maintenance, ! alpha-beta T cell differentiation GO:0046632 7 7 0,000 0,02118077 0,05260939 ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,02118077 0,05253858 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,02118077 0,05246797 ! axon cargo transport GO:0008088 7 7 0,000 0,02118077 0,05239754 ! eating behavior GO:0042755 7 7 0,000 0,02118077 0,0523273 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,02118077 0,05225725 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,02118077 0,05218739 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,02118077 0,05211771 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,02118077 0,05204822 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,02118077 0,05197892 ! cranial nerve development GO:0021545 7 7 0,000 0,02118077 0,0519098 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,02118077 0,05184086 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,02118077 0,0517721 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,02118077 0,05170353 ! autonomic nervous system development GO:0048483 7 7 0,000 0,02118077 0,05163514 ! intracellular lipid transport GO:0032365 7 7 0,000 0,02118077 0,05156693 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,02118077 0,0514989 ! platelet activation GO:0030168 8 7 0,000 0,02118077 0,05143105 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,02118077 0,05136338 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,02118077 0,05129588 ! natural killer cell activation GO:0030101 7 7 0,000 0,02118077 0,05122856 ! NADP metabolic process GO:0006739 7 7 0,000 0,02118077 0,05116142 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,02118077 0,05109446 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,02118077 0,05102767 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,02118077 0,05096105 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,02118077 0,05089461 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,02118077 0,05082834 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,02118077 0,05076224 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,02118077 0,05069632 ! cell-cell recognition GO:0009988 8 7 0,000 0,02118077 0,05063057 ! hormone catabolic process GO:0042447 7 7 0,000 0,02118077 0,05056498 ! dopamine metabolic process GO:0042417 7 7 0,000 0,02118077 0,05049957 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,02118077 0,05043432 ! oxygen transport GO:0015671 7 7 0,000 0,02118077 0,05036925 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,02118077 0,05030434 ! regulation of mRNA stability GO:0043488 7 7 0,000 0,02118077 0,0502396 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,02118077 0,05017502 ! regulation of axon extension GO:0030516 7 7 0,000 0,02118077 0,05011061 ! cell killing GO:0001906 7 7 0,000 0,02118077 0,05004637 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,02118077 0,04998229 ! adult feeding behavior GO:0008343 7 7 0,000 0,02118077 0,04991837 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,02118077 0,04985462 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,02118077 0,04979103 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,02118077 0,0497276 ! response to cold GO:0009409 7 7 0,000 0,02118077 0,04966433 ! response to oxidative stress GO:0006979 76 75 1,000 0,02153893 0,05043996 ! cellular metal ion homeostasis GO:0006875 77 77 1,000 0,02262817 0,05292351 ! cell morphogenesis involved in differentiation GO:0000904 82 77 1,000 0,02262817 0,05285643 ! positive regulation of protein kinase cascade GO:0010740 79 78 1,000 0,02318129 0,0540799 ! metal ion homeostasis GO:0055065 78 78 1,000 0,02318129 0,05401153 ! nuclear transport GO:0051169 79 79 1,000 0,02374003 0,05524354 GO:0006913|nucleocytoplasmic transport, ! regulation of skeletal muscle tissue development GO:0048641 8 8 0,000 0,02417149 0,05617662 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,02417149 0,05610587 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,02417149 0,05603529 ! positive regulation of translation GO:0045727 8 8 0,000 0,02417149 0,0559649 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,02417149 0,05589468 ! superoxide anion generation GO:0042554 8 8 0,000 0,02417149 0,05582464 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,02417149 0,05575477 ! cGMP metabolic process GO:0046068 8 8 0,000 0,02417149 0,05568507 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,02417149 0,05561555 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,02417149 0,05554621 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,02417149 0,05547704 ! negative regulation of bone remodeling GO:0046851 8 8 0,000 0,02417149 0,05540803 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,02417149 0,0553392 ! zinc ion transport GO:0006829 8 8 0,000 0,02417149 0,05527055 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,02417149 0,05520206 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,02417149 0,05513374 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,02417149 0,05506559 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,02417149 0,0549976 ! lipid localization GO:0010876 8 8 0,000 0,02417149 0,05492979 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,02417149 0,05486214 ! response to cAMP GO:0051591 8 8 0,000 0,02417149 0,05479466 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,02417149 0,05472735 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,02417149 0,0546602 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,02417149 0,05459321 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,02417149 0,05452639 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,02417149 0,05445973 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,02417149 0,05439323 ! sensory perception of taste GO:0050909 8 8 0,000 0,02417149 0,0543269 ! organelle fusion GO:0048284 8 8 0,000 0,02417149 0,05426073 ! pancreas development GO:0031016 8 8 0,000 0,02417149 0,05419472 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,02417149 0,05412887 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! T cell selection GO:0045058 8 8 0,000 0,02417149 0,05406318 ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,02417149 0,05399765 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,02417149 0,05393228 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,02417149 0,05386706 ! sperm motility GO:0030317 8 8 0,000 0,02417149 0,053802 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,02417149 0,0537371 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,02417149 0,05367236 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,02417149 0,05360777 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,02417149 0,05354334 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,02417149 0,05347906 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,02417149 0,05341494 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,02417149 0,05335097 ! Golgi organization GO:0007030 8 8 0,000 0,02417149 0,05328715 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,02417149 0,05322349 ! positive regulation of endothelial cell migration GO:0010595 8 8 0,000 0,02417149 0,05315998 ! fructose metabolic process GO:0006000 8 8 0,000 0,02417149 0,05309661 ! mannose metabolic process GO:0006013 9 8 0,000 0,02417149 0,0530334 ! NAD metabolic process GO:0019674 8 8 0,000 0,02417149 0,05297034 ! negative regulation of mitotic cell cycle GO:0045930 9 8 0,000 0,02417149 0,05290743 ! plasma membrane fusion GO:0045026 8 8 0,000 0,02417149 0,05284467 ! response to fungus GO:0009620 8 8 0,000 0,02417149 0,05278206 ! stem cell differentiation GO:0048863 8 8 0,000 0,02417149 0,0527196 ! alpha-beta T cell activation GO:0046631 8 8 0,000 0,02417149 0,05265728 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,02417149 0,05259511 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,02417149 0,05253309 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,02417149 0,05247121 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,02417149 0,05240948 ! regulation of vasodilation GO:0042312 8 8 0,000 0,02417149 0,0523479 ! vasoconstriction GO:0042310 8 8 0,000 0,02417149 0,05228645 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,02417149 0,05222516 ! muscle cell development GO:0055001 8 8 0,000 0,02417149 0,052164 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,02417149 0,05210299 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,02417149 0,05204213 ! sensory perception of pain GO:0019233 8 8 0,000 0,02417149 0,0519814 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,02417149 0,05192082 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,02417149 0,05186037 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,02417149 0,05180007 ! chromatin silencing GO:0006342 8 8 0,000 0,02417149 0,05173991 ! tissue regeneration GO:0042246 8 8 0,000 0,02417149 0,05167988 ! salivary gland development GO:0007431 8 8 0,000 0,02417149 0,05162 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,02417149 0,05156025 ! T cell homeostasis GO:0043029 8 8 0,000 0,02417149 0,05150065 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,02417149 0,05144118 ! peptidyl-serine modification GO:0018209 8 8 0,000 0,02417149 0,05138184 ! water homeostasis GO:0030104 8 8 0,000 0,02417149 0,05132265 ! cofactor transport GO:0051181 8 8 0,000 0,02417149 0,05126359 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,02417149 0,05120467 ! acid secretion GO:0046717 8 8 0,000 0,02417149 0,05114588 ! positive regulation of leukocyte migration GO:0002687 8 8 0,000 0,02417149 0,05108722 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,02417149 0,0510287 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,02417149 0,05097032 ! regulation of immunoglobulin production GO:0002637 8 8 0,000 0,02417149 0,05091207 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,02417149 0,05085395 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,02417149 0,05079596 ! regulation of RNA stability GO:0043487 8 8 0,000 0,02417149 0,05073811 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,02417149 0,05068039 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,02417149 0,05062279 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,02417149 0,05056533 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,02417149 0,050508 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,02417149 0,0504508 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,02417149 0,05039373 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,02417149 0,05033679 ! peptide hormone secretion GO:0030072 8 8 0,000 0,02417149 0,05027998 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,02417149 0,05022329 ! actin filament polymerization GO:0030041 9 8 0,000 0,02417149 0,05016673 ! peptide hormone processing GO:0016486 8 8 0,000 0,02417149 0,0501103 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,02417149 0,050054 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,02417149 0,04999782 ! neuron projection development GO:0031175 85 80 1,000 0,02430435 0,05021628 ! MAPKKK cascade GO:0000165 82 81 1,000 0,02487422 0,05133616 ! lymphocyte activation GO:0046649 82 81 1,000 0,02487422 0,05127874 ! blood vessel morphogenesis GO:0048514 84 83 1,000 0,02603046 0,05360238 ! lactation GO:0007595 10 9 0,000 0,02715351 0,05585258 ! embryonic pattern specification GO:0009880 10 9 0,000 0,02715351 0,05579031 ! positive regulation of cell size GO:0045793 9 9 0,000 0,02715351 0,05572819 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,02715351 0,0556662 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,02715351 0,05560435 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,02715351 0,05554263 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,02715351 0,05548105 ! negative regulation of cell cycle process GO:0010948 9 9 0,000 0,02715351 0,05541961 ! viral genome replication GO:0019079 9 9 0,000 0,02715351 0,05535831 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,02715351 0,05529714 ! copper ion transport GO:0006825 9 9 0,000 0,02715351 0,0552361 ! lipid phosphorylation GO:0046834 9 9 0,000 0,02715351 0,0551752 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,02715351 0,05511444 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,02715351 0,05505381 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,02715351 0,05499331 ! RNA polyadenylation GO:0043631 9 9 0,000 0,02715351 0,05493294 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,02715351 0,05487271 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,02715351 0,05481261 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,02715351 0,05475264 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,02715351 0,0546928 ! phospholipid efflux GO:0033700 9 9 0,000 0,02715351 0,05463309 ! response to alkaloid GO:0043279 10 9 0,000 0,02715351 0,05457351 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,02715351 0,05451406 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,02715351 0,05445475 GO:0042107|cytokine metabolic process, ! positive regulation of endothelial cell proliferation GO:0001938 9 9 0,000 0,02715351 0,05439556 ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,02715351 0,05433649 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,02715351 0,05427756 ! response to ethanol GO:0045471 9 9 0,000 0,02715351 0,05421875 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,02715351 0,05416008 ! activation of pro-apoptotic gene products GO:0008633 9 9 0,000 0,02715351 0,05410153 ! methionine metabolic process GO:0006555 9 9 0,000 0,02715351 0,0540431 ! glutamine metabolic process GO:0006541 9 9 0,000 0,02715351 0,0539848 ! cerebral cortex development GO:0021987 9 9 0,000 0,02715351 0,05392663 ! response to osmotic stress GO:0006970 9 9 0,000 0,02715351 0,05386858 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,02715351 0,05381066 ! central nervous system neuron development GO:0021954 10 9 0,000 0,02715351 0,05375286 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,02715351 0,05369518 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,02715351 0,05363763 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,02715351 0,0535802 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,02715351 0,0535229 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,02715351 0,05346572 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 0,000 0,02715351 0,05340866 GO:0060675|ureteric bud morphogenesis, ! peptide secretion GO:0002790 9 9 0,000 0,02715351 0,05335172 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,02715351 0,0532949 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,02715351 0,0532382 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,02715351 0,05318163 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,02715351 0,05312517 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,02715351 0,05306883 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,02715351 0,05301262 ! DNA replication initiation GO:0006270 9 9 0,000 0,02715351 0,05295652 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,02715351 0,05290054 GO:0006692|prostanoid metabolic process, ! T cell differentiation in the thymus GO:0033077 9 9 0,000 0,02715351 0,05284468 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,02715351 0,05278894 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,02715351 0,05273331 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,02715351 0,0526778 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,02715351 0,05262241 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,02715351 0,05256713 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,02715351 0,05251197 ! negative regulation of tissue remodeling GO:0034104 9 9 0,000 0,02715351 0,05245693 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,02715351 0,052402 ! regulation of leukocyte migration GO:0002685 9 9 0,000 0,02715351 0,05234719 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,02715351 0,05229249 ! collagen catabolic process GO:0030574 9 9 0,000 0,02715351 0,0522379 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,02715351 0,05218343 ! purine base metabolic process GO:0006144 9 9 0,000 0,02715351 0,05212907 ! gas transport GO:0015669 9 9 0,000 0,02715351 0,05207483 ! cholesterol efflux GO:0033344 9 9 0,000 0,02715351 0,0520207 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,02715351 0,05196668 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,02715351 0,05191277 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,02715351 0,05185897 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,02715351 0,05180529 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 0,000 0,02715351 0,05175172 ! defense response to virus GO:0051607 9 9 0,000 0,02715351 0,05169825 ! actin filament-based movement GO:0030048 9 9 0,000 0,02715351 0,0516449 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,02715351 0,05159166 ! nitrogen compound biosynthetic process GO:0044271 86 85 1,000 0,02720845 0,05164282 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 1,000 0,02780552 0,05272178 ! male gamete generation GO:0048232 90 88 1,000 0,02901563 0,05495972 GO:0007283|spermatogenesis, ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 1,000 0,0296286 0,05606315 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,03012684 0,05694745 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,03012684 0,0568891 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,03012684 0,05683088 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,03012684 0,05677277 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,03012684 0,05671478 ! neuron maturation GO:0042551 10 10 0,000 0,03012684 0,0566569 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,03012684 0,05659915 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,03012684 0,05654151 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,03012684 0,05648399 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,03012684 0,05642659 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,03012684 0,0563693 ! hormone secretion GO:0046879 10 10 0,000 0,03012684 0,05631213 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,03012684 0,05625508 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,03012684 0,05619814 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! inositol metabolic process GO:0006020 10 10 0,000 0,03012684 0,05614132 ! cAMP metabolic process GO:0046058 10 10 0,000 0,03012684 0,05608461 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,03012684 0,05602802 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,03012684 0,05597154 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,03012684 0,05591517 ! glial cell development GO:0021782 10 10 0,000 0,03012684 0,05585892 ! phototransduction GO:0007602 11 10 0,000 0,03012684 0,05580278 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,03012684 0,05574675 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,03012684 0,05569084 ! fat cell differentiation GO:0045444 10 10 0,000 0,03012684 0,05563503 ! myoblast differentiation GO:0045445 10 10 0,000 0,03012684 0,05557934 ! centrosome cycle GO:0007098 10 10 0,000 0,03012684 0,05552376 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,03012684 0,0554683 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,03012684 0,05541294 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,03012684 0,05535769 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,03012684 0,05530255 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,03012684 0,05524753 ! epidermis morphogenesis GO:0048730 10 10 0,000 0,03012684 0,05519261 ! protein polyubiquitination GO:0000209 10 10 0,000 0,03012684 0,0551378 ! glutamate metabolic process GO:0006536 11 10 0,000 0,03012684 0,0550831 ! plasma membrane organization GO:0007009 10 10 0,000 0,03012684 0,05502851 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,03012684 0,05497402 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cell-substrate junction assembly GO:0007044 11 10 0,000 0,03012684 0,05491965 ! lysosomal transport GO:0007041 10 10 0,000 0,03012684 0,05486538 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,03012684 0,05481122 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,03012684 0,05475716 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,03012684 0,05470322 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,03012684 0,05464937 ! exocrine system development GO:0035272 10 10 0,000 0,03012684 0,05459564 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,03012684 0,05454201 ! embryo implantation GO:0007566 11 10 0,000 0,03012684 0,05448848 ! regulation of protein binding GO:0043393 11 10 0,000 0,03012684 0,05443506 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,03012684 0,05438175 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,03012684 0,05432854 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,03012684 0,05427543 ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,03012684 0,05422243 ! protein export from nucleus GO:0006611 10 10 0,000 0,03012684 0,05416953 ! negative regulation of immune response GO:0050777 10 10 0,000 0,03012684 0,05411673 ! cytolysis GO:0019835 10 10 0,000 0,03012684 0,05406404 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,03012684 0,05401144 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,03012684 0,05395896 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,03012684 0,05390657 ! histone deacetylation GO:0016575 10 10 0,000 0,03012684 0,05385428 ! mRNA splice site selection GO:0006376 11 10 0,000 0,03012684 0,0538021 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,03012684 0,05375001 ! gland morphogenesis GO:0022612 10 10 0,000 0,03012684 0,05369803 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,03012684 0,05364615 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,03012684 0,05359437 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,03012684 0,05354269 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,03012684 0,0534911 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,03012684 0,05343962 ! regulation of epidermis development GO:0045682 10 10 0,000 0,03012684 0,05338824 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,03012684 0,05333695 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,03012684 0,05328576 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,03012684 0,05323467 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,03012684 0,05318368 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,03012684 0,05313279 ! lymphocyte homeostasis GO:0002260 10 10 0,000 0,03012684 0,05308199 ! nerve development GO:0021675 10 10 0,000 0,03012684 0,05303129 ! epithelial to mesenchymal transition GO:0001837 10 10 0,000 0,03012684 0,05298069 ! gut development GO:0048565 10 10 0,000 0,03012684 0,05293019 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,03012684 0,05287978 ! negative regulation of homeostatic process GO:0032845 10 10 0,000 0,03012684 0,05282946 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,03012684 0,05277924 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,03012684 0,05272912 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,03012684 0,05267909 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 1,000 0,0308702 0,05392775 ! blood vessel development GO:0001568 95 94 1,000 0,03277123 0,05719449 ! pattern specification process GO:0007389 96 94 1,000 0,03277123 0,05714038 ! protein secretion GO:0009306 11 11 0,000 0,03309152 0,0576443 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,03309152 0,05758986 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,03309152 0,05753553 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,03309152 0,05748131 ! negative regulation of defense response GO:0031348 11 11 0,000 0,03309152 0,05742718 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,03309152 0,05737316 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,03309152 0,05731923 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,03309152 0,05726541 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,03309152 0,05721169 ! skin development GO:0043588 11 11 0,000 0,03309152 0,05715808 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,03309152 0,05710456 ! microtubule-based transport GO:0010970 11 11 0,000 0,03309152 0,05705114 ! endothelial cell migration GO:0043542 11 11 0,000 0,03309152 0,05699782 ! peroxisomal transport GO:0043574 11 11 0,000 0,03309152 0,0569446 ! protein amino acid methylation GO:0006479 11 11 0,000 0,03309152 0,05689148 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,03309152 0,05683846 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,03309152 0,05678554 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,03309152 0,05673271 ! T cell proliferation GO:0042098 11 11 0,000 0,03309152 0,05667999 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,03309152 0,05662736 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,03309152 0,05657483 ! regulation of viral genome replication GO:0045069 11 11 0,000 0,03309152 0,0565224 ! spinal cord development GO:0021510 11 11 0,000 0,03309152 0,05647006 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,03309152 0,05641782 ! smooth muscle contraction GO:0006939 11 11 0,000 0,03309152 0,05636568 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,03309152 0,05631363 ! digestive system process GO:0022600 11 11 0,000 0,03309152 0,05626168 ! mitotic spindle organization GO:0007052 11 11 0,000 0,03309152 0,05620983 ! fucose metabolic process GO:0006004 11 11 0,000 0,03309152 0,05615807 ! membrane budding GO:0006900 11 11 0,000 0,03309152 0,05610641 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,03309152 0,05605484 ! monoamine transport GO:0015844 11 11 0,000 0,03309152 0,05600337 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,03309152 0,05595199 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,03309152 0,0559007 ! body fluid secretion GO:0007589 11 11 0,000 0,03309152 0,05584951 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 0,000 0,03309152 0,05579841 ! intermediate filament-based process GO:0045103 11 11 0,000 0,03309152 0,05574741 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,03309152 0,0556965 GO:0060415|muscle tissue morphogenesis, ! membrane depolarization GO:0051899 11 11 0,000 0,03309152 0,05564568 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,03309152 0,05559496 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,03309152 0,05554432 ! oogenesis GO:0048477 11 11 0,000 0,03309152 0,05549378 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,03309152 0,05544333 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,03309152 0,05539298 ! vitamin transport GO:0051180 11 11 0,000 0,03309152 0,05534271 ! muscle maintenance GO:0046716 12 11 0,000 0,03309152 0,05529253 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,03309152 0,05524245 ! hindbrain development GO:0030902 11 11 0,000 0,03309152 0,05519246 ! steroid catabolic process GO:0006706 11 11 0,000 0,03309152 0,05514256 ! endocrine process GO:0050886 11 11 0,000 0,03309152 0,05509274 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,03309152 0,05504302 ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,03309152 0,05499339 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,03309152 0,05494384 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,03309152 0,05489439 ! regulation of cell growth GO:0001558 97 96 1,000 0,03406395 0,0564567 ! vasculature development GO:0001944 97 96 1,000 0,03406395 0,05640598 ! anti-apoptosis GO:0006916 100 99 1,000 0,03604039 0,05962517 ! translational initiation GO:0006413 12 12 0,000 0,03604756 0,05958355 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,03604756 0,05953016 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,03604756 0,05947687 ! initiation of viral infection GO:0019059 12 12 0,000 0,03604756 0,05942367 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,03604756 0,05937056 ! iron ion transport GO:0006826 13 12 0,000 0,03604756 0,05931755 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,03604756 0,05926464 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,03604756 0,05921182 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,03604756 0,05915909 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,03604756 0,05910646 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,03604756 0,05905392 ! collagen metabolic process GO:0032963 12 12 0,000 0,03604756 0,05900147 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,03604756 0,05894912 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,03604756 0,05889686 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,03604756 0,05884469 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,03604756 0,05879262 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,03604756 0,05874064 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,03604756 0,05868874 ! actomyosin structure organization GO:0031032 12 12 0,000 0,03604756 0,05863694 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,03604756 0,05858524 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,03604756 0,05853362 ! retinoid metabolic process GO:0001523 12 12 0,000 0,03604756 0,05848209 GO:0016101|diterpenoid metabolic process, ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,03604756 0,05843066 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,03604756 0,05837931 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,03604756 0,05832806 ! acute-phase response GO:0006953 12 12 0,000 0,03604756 0,05827689 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,03604756 0,05822582 ! vacuolar transport GO:0007034 12 12 0,000 0,03604756 0,05817483 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,03604756 0,05812394 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,03604756 0,05807313 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,03604756 0,05802241 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,03604756 0,05797178 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,03604756 0,05792124 ! male gonad development GO:0008584 12 12 0,000 0,03604756 0,05787078 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,03604756 0,05782042 ! regulation of alpha-beta T cell activation GO:0046634 12 12 0,000 0,03604756 0,05777014 ! renal system process GO:0003014 12 12 0,000 0,03604756 0,05771995 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,03604756 0,05766984 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,03604756 0,05761983 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,03604756 0,05756989 ! pallium development GO:0021543 13 12 0,000 0,03604756 0,05752005 ! cell fate determination GO:0001709 12 12 0,000 0,03604756 0,05747029 ! regulation of chromosome organization GO:0033044 12 12 0,000 0,03604756 0,05742062 ! positive regulation of multicellular organism growth GO:0040018 12 12 0,000 0,03604756 0,05737103 ! G1 phase GO:0051318 13 12 0,000 0,03604756 0,05732153 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,03604756 0,05727212 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,03604756 0,05722279 ! detection of light stimulus GO:0009583 13 12 0,000 0,03604756 0,05717354 ! synaptogenesis GO:0007416 12 12 0,000 0,03604756 0,05712438 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,03604756 0,05707531 ! hormone transport GO:0009914 12 12 0,000 0,03604756 0,05702632 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,03604756 0,05697741 ! heme biosynthetic process GO:0006783 12 12 0,000 0,03604756 0,05692858 ! spermatid differentiation GO:0048515 13 12 0,000 0,03604756 0,05687984 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,03604756 0,05683119 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,03604756 0,05678261 ! neural tube closure GO:0001843 13 12 0,000 0,03604756 0,05673412 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 0,000 0,03604756 0,05668572 ! negative regulation of translation GO:0017148 12 12 0,000 0,03604756 0,05663739 ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 0,000 0,03604756 0,05658915 ! response to hormone stimulus GO:0009725 102 100 1,000 0,03670904 0,05757852 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 1,000 0,03670904 0,05752956 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 0,000 0,038995 0,06106014 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,038995 0,06100831 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,038995 0,06095656 ! phenol metabolic process GO:0018958 13 13 0,000 0,038995 0,0609049 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,038995 0,06085333 ! gluconeogenesis GO:0006094 13 13 0,000 0,038995 0,06080185 ! negative regulation of hormone secretion GO:0046888 13 13 0,000 0,038995 0,06075045 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,038995 0,06069914 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,038995 0,06064792 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,038995 0,06059678 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,038995 0,06054573 ! regeneration GO:0031099 13 13 0,000 0,038995 0,06049477 ! keratinization GO:0031424 13 13 0,000 0,038995 0,06044389 ! post-embryonic development GO:0009791 14 13 0,000 0,038995 0,0603931 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,038995 0,06034239 ! patterning of blood vessels GO:0001569 13 13 0,000 0,038995 0,06029177 ! vasculogenesis GO:0001570 13 13 0,000 0,038995 0,06024123 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,038995 0,06019078 ! regulation of innate immune response GO:0045088 13 13 0,000 0,038995 0,06014041 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,038995 0,06009012 ! response to corticosteroid stimulus GO:0031960 13 13 0,000 0,038995 0,06003992 GO:0051384|response to glucocorticoid stimulus, ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,038995 0,0599898 ! autophagy GO:0006914 13 13 0,000 0,038995 0,05993977 ! actin filament bundle formation GO:0051017 13 13 0,000 0,038995 0,05988982 ! ureteric bud development GO:0001657 13 13 0,000 0,038995 0,05983995 ! regulation of endothelial cell migration GO:0010594 13 13 0,000 0,038995 0,05979017 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,038995 0,05974047 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,038995 0,05969085 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,038995 0,05964132 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,038995 0,05959186 ! regulation of viral reproduction GO:0050792 13 13 0,000 0,038995 0,05954249 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,038995 0,0594932 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,038995 0,05944399 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,038995 0,05939486 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,038995 0,05934582 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,038995 0,05929685 ! vasodilation GO:0042311 14 13 0,000 0,038995 0,05924797 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,038995 0,05919916 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 0,000 0,038995 0,05915044 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,038995 0,0591018 GO:0006664|glycolipid metabolic process, ! positive regulation of locomotion GO:0040017 13 13 0,000 0,038995 0,05905323 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! neural crest cell migration GO:0001755 14 13 0,000 0,038995 0,05900475 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,038995 0,05895635 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,038995 0,05890802 ! immunoglobulin production GO:0002377 13 13 0,000 0,038995 0,05885978 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,038995 0,05881161 ! regulation of cell-substrate adhesion GO:0010810 14 13 0,000 0,038995 0,05876352 GO:0001952|regulation of cell-matrix adhesion, ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,038995 0,05871551 ! response to cytokine stimulus GO:0034097 13 13 0,000 0,038995 0,05866758 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,038995 0,05861973 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,038995 0,05857195 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,038995 0,05852426 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,038995 0,05847664 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,038995 0,05842909 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,038995 0,05838163 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,038995 0,05833424 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,038995 0,05828693 ! blastocyst development GO:0001824 13 13 0,000 0,038995 0,0582397 ! telomere organization GO:0032200 13 13 0,000 0,038995 0,05819254 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,038995 0,05814546 ! regulation of amine transport GO:0051952 13 13 0,000 0,038995 0,05809845 ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,038995 0,05805152 ! neuron fate commitment GO:0048663 14 14 0,000 0,04193385 0,06237618 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,04193385 0,06232588 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,04193385 0,06227566 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,04193385 0,06222552 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,04193385 0,06217546 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,04193385 0,06212548 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,04193385 0,06207558 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,04193385 0,06202576 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,04193385 0,06197602 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,04193385 0,06192636 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,04193385 0,06187678 ! vesicle docking GO:0048278 14 14 0,000 0,04193385 0,06182727 ! superoxide metabolic process GO:0006801 15 14 0,000 0,04193385 0,06177785 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,04193385 0,06172851 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,04193385 0,06167924 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,04193385 0,06163006 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,04193385 0,06158095 ! hair cycle GO:0042633 14 14 0,000 0,04193385 0,06153192 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,04193385 0,06148297 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,04193385 0,0614341 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to retinoic acid GO:0032526 14 14 0,000 0,04193385 0,0613853 GO:0033189|response to vitamin A, ! multicellular organismal response to stress GO:0033555 14 14 0,000 0,04193385 0,06133658 ! lysosome organization GO:0007040 14 14 0,000 0,04193385 0,06128794 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,04193385 0,06123938 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,04193385 0,06119089 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 0,000 0,04193385 0,06114248 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 0,000 0,04193385 0,06109414 ! primary neural tube formation GO:0014020 15 14 0,000 0,04193385 0,06104589 ! peptide cross-linking GO:0018149 14 14 0,000 0,04193385 0,0609977 ! regulation of behavior GO:0050795 14 14 0,000 0,04193385 0,0609496 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,04193385 0,06090157 ! response to organic cyclic substance GO:0014070 15 14 0,000 0,04193385 0,06085362 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,04193385 0,06080574 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,04193385 0,06075793 ! formation of primary germ layer GO:0001704 14 14 0,000 0,04193385 0,06071021 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,04193385 0,06066255 ! collagen fibril organization GO:0030199 14 14 0,000 0,04193385 0,06061497 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,04193385 0,06056747 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,04193385 0,06052004 ! positive regulation of inflammatory response GO:0050729 14 14 0,000 0,04193385 0,06047269 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,04193385 0,0604254 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,04193385 0,0603782 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,04193385 0,06033106 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,04193385 0,060284 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,04193385 0,06023702 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,04193385 0,0601901 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,04486415 0,06434601 ! positive regulation of ossification GO:0045778 15 15 0,000 0,04486415 0,06429597 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,04486415 0,06424602 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,04486415 0,06419613 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,04486415 0,06414633 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,04486415 0,06409661 ! response to vitamin GO:0033273 15 15 0,000 0,04486415 0,06404696 ! striated muscle cell differentiation GO:0051146 16 15 0,000 0,04486415 0,06399739 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,04486415 0,06394789 ! ovarian follicle development GO:0001541 15 15 0,000 0,04486415 0,06389847 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,04486415 0,06384913 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,04486415 0,06379986 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,04486415 0,06375067 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,04486415 0,06370156 ! heme metabolic process GO:0042168 15 15 0,000 0,04486415 0,06365252 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,04486415 0,06360355 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,04486415 0,06355467 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,04486415 0,06350585 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,04486415 0,06345712 GO:0030500|regulation of bone mineralization, ! regulation of production of molecular mediator of immune response GO:0002700 15 15 0,000 0,04486415 0,06340845 ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,04486415 0,06335986 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,04486415 0,06331135 ! phospholipid transport GO:0015914 15 15 0,000 0,04486415 0,06326291 ! leukocyte homeostasis GO:0001776 15 15 0,000 0,04486415 0,06321454 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,04486415 0,06316625 ! glutathione metabolic process GO:0006749 16 15 0,000 0,04486415 0,06311803 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,04486415 0,06306989 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of B cell activation GO:0050871 15 15 0,000 0,04486415 0,06302182 ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,04486415 0,06297382 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,04486415 0,06292589 ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,04486415 0,06287804 ! protein homooligomerization GO:0051260 15 15 0,000 0,04486415 0,06283026 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,04486415 0,06278255 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,0477859 0,0668205 ! alkaloid metabolic process GO:0009820 16 16 0,000 0,0477859 0,06676984 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,0477859 0,06671926 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,0477859 0,06666875 ! learning GO:0007612 16 16 0,000 0,0477859 0,06661832 ! circadian rhythm GO:0007623 16 16 0,000 0,0477859 0,06656796 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,0477859 0,06651769 ! positive regulation of mitosis GO:0045840 16 16 0,000 0,0477859 0,06646748 GO:0051785|positive regulation of nuclear division, ! vacuole organization GO:0007033 16 16 0,000 0,0477859 0,06641736 ! cellular response to reactive oxygen species GO:0034614 16 16 0,000 0,0477859 0,06636731 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,0477859 0,06631733 ! vesicle targeting GO:0006903 17 16 0,000 0,0477859 0,06626743 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,0477859 0,06621761 ! triglyceride metabolic process GO:0006641 16 16 0,000 0,0477859 0,06616786 ! iron ion homeostasis GO:0055072 16 16 0,000 0,0477859 0,06611818 ! positive regulation of cell development GO:0010720 16 16 0,000 0,0477859 0,06606858 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,0477859 0,06601905 ! lymphocyte proliferation GO:0046651 16 16 0,000 0,0477859 0,0659696 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,0477859 0,06592022 ! pentose metabolic process GO:0019321 16 16 0,000 0,0477859 0,06587092 ! fatty acid transport GO:0015908 16 16 0,000 0,0477859 0,06582169 ! positive regulation of MAPKKK cascade GO:0043410 17 16 0,000 0,0477859 0,06577253 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 0,000 0,0477859 0,06572345 ! cofactor catabolic process GO:0051187 16 16 0,000 0,0477859 0,06567443 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,0477859 0,0656255 ! polyol metabolic process GO:0019751 16 16 0,000 0,0477859 0,06557663 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,0477859 0,06552784 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,0477859 0,06547912 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,0477859 0,06543047 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,0477859 0,0653819 GO:0001841|neural tube formation, ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,0477859 0,0653334 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,0477859 0,06528496 ! regulation of coagulation GO:0050818 17 16 0,000 0,0477859 0,06523661 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 0,000 0,05069914 0,06916249 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 0,000 0,05069914 0,06911133 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,05069914 0,06906025 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,05069914 0,06900925 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,05069914 0,06895832 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,05069914 0,06890747 ! leukocyte adhesion GO:0007159 17 17 0,000 0,05069914 0,06885669 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,05069914 0,06880598 ! sensory perception of smell GO:0007608 17 17 0,000 0,05069914 0,06875535 ! glucose transport GO:0015758 17 17 0,000 0,05069914 0,0687048 ! tissue remodeling GO:0048771 17 17 0,000 0,05069914 0,06865432 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,05069914 0,06860391 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,05069914 0,06855358 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,05069914 0,06850332 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,05069914 0,06845313 ! neural crest cell development GO:0014032 19 17 0,000 0,05069914 0,06840302 GO:0014033|neural crest cell differentiation, ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,05069914 0,06835298 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,05069914 0,06830301 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,05069914 0,06825312 ! regulation of osteoblast differentiation GO:0045667 17 17 0,000 0,05069914 0,0682033 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,05069914 0,06815355 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,05069914 0,06810388 ! adult locomotory behavior GO:0008344 17 17 0,000 0,05069914 0,06805428 ! embryonic organ development GO:0048568 17 17 0,000 0,05069914 0,06800475 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,05069914 0,06795529 ! liver development GO:0001889 17 17 0,000 0,05069914 0,0679059 ! gene silencing GO:0016458 17 17 0,000 0,05069914 0,06785659 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,0536039 0,07169229 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,0536039 0,07164031 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,0536039 0,07158839 ! meiosis I GO:0007127 18 18 0,000 0,0536039 0,07153655 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,0536039 0,07148479 ! membrane docking GO:0022406 18 18 0,000 0,0536039 0,0714331 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,0536039 0,07138149 ! mononuclear cell proliferation GO:0032943 18 18 0,000 0,0536039 0,07132995 GO:0070661|leukocyte proliferation, ! response to calcium ion GO:0051592 18 18 0,000 0,0536039 0,07127849 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,0536039 0,0712271 ! hexose transport GO:0008645 18 18 0,000 0,0536039 0,07117578 GO:0015749|monosaccharide transport, ! cholesterol homeostasis GO:0042632 18 18 0,000 0,0536039 0,07112454 GO:0055092|sterol homeostasis, ! striated muscle contraction GO:0006941 18 18 0,000 0,0536039 0,07107337 ! neutral lipid metabolic process GO:0006638 18 18 0,000 0,0536039 0,07102227 GO:0006639|acylglycerol metabolic process, ! ceramide metabolic process GO:0006672 18 18 0,000 0,0536039 0,07097125 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,0536039 0,0709203 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,0536039 0,07086943 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,0536039 0,07081863 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,0536039 0,0707679 ! BMP signaling pathway GO:0030509 18 18 0,000 0,0536039 0,07071724 ! regulation of microtubule-based process GO:0032886 18 18 0,000 0,0536039 0,07066665 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,0536039 0,07061614 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,05650018 0,07437846 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,05650018 0,07432537 GO:0006956|complement activation, ! glial cell differentiation GO:0010001 19 19 0,000 0,05650018 0,07427235 ! regulation of JAK-STAT cascade GO:0046425 19 19 0,000 0,05650018 0,07421941 ! feeding behavior GO:0007631 19 19 0,000 0,05650018 0,07416655 ! regulation of endothelial cell proliferation GO:0001936 19 19 0,000 0,05650018 0,07411376 ! peroxisome organization GO:0007031 19 19 0,000 0,05650018 0,07406105 ! positive regulation of T cell proliferation GO:0042102 19 19 0,000 0,05650018 0,07400841 ! regulation of striated muscle tissue development GO:0016202 20 19 0,000 0,05650018 0,07395585 ! multicellular organismal metabolic process GO:0044236 19 19 0,000 0,05650018 0,07390336 ! metanephros development GO:0001656 19 19 0,000 0,05650018 0,07385095 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,05650018 0,07379861 ! cellular response to oxidative stress GO:0034599 19 19 0,000 0,05650018 0,07374634 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,05650018 0,07369415 ! positive regulation of T cell differentiation GO:0045582 19 19 0,000 0,05650018 0,07364204 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,05650018 0,07358999 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,05650018 0,07353802 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,05650018 0,07348612 ! dorsal/ventral pattern formation GO:0009953 19 19 0,000 0,05650018 0,0734343 ! eye morphogenesis GO:0048592 19 19 0,000 0,05650018 0,07338255 ! regulation of cell shape GO:0008360 21 19 0,000 0,05650018 0,07333087 ! placenta development GO:0001890 19 19 0,000 0,05650018 0,07327927 ! vesicle localization GO:0051648 20 19 0,000 0,05650018 0,07322773 ! regulation of muscle development GO:0048634 21 20 0,000 0,05938803 0,07691647 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,05938803 0,07686245 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,05938803 0,07680852 ! organic ether metabolic process GO:0018904 20 20 0,000 0,05938803 0,07675465 GO:0006662|glycerol ether metabolic process, ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 0,000 0,05938803 0,07670087 ! neural tube development GO:0021915 21 20 0,000 0,05938803 0,07664715 ! nucleus organization GO:0006997 20 20 0,000 0,05938803 0,07659352 ! phagocytosis GO:0006909 21 20 0,000 0,05938803 0,07653995 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,05938803 0,07648647 ! protein targeting to membrane GO:0006612 22 20 0,000 0,05938803 0,07643305 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,05938803 0,07637972 ! chromatin remodeling GO:0006338 20 20 0,000 0,05938803 0,07632645 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,05938803 0,07627326 ! lipid oxidation GO:0034440 20 20 0,000 0,05938803 0,07622015 GO:0019395|fatty acid oxidation, ! female gamete generation GO:0007292 20 20 0,000 0,05938803 0,07616711 ! negative regulation of neuron apoptosis GO:0043524 21 20 0,000 0,05938803 0,07611414 ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,05938803 0,07606125 ! RNA modification GO:0009451 20 20 0,000 0,05938803 0,07600843 ! single fertilization GO:0007338 21 20 0,000 0,05938803 0,07595568 ! regulation of B cell activation GO:0050864 20 20 0,000 0,05938803 0,07590301 ! mRNA catabolic process GO:0006402 21 21 0,000 0,06226745 0,07952801 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,06226745 0,07947293 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,06226745 0,07941793 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,06226745 0,07936301 ! Notch signaling pathway GO:0007219 22 21 0,000 0,06226745 0,07930816 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,06226745 0,07925339 ! ear morphogenesis GO:0042471 21 21 0,000 0,06226745 0,0791987 ! cholesterol transport GO:0030301 21 21 0,000 0,06226745 0,07914408 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,06226745 0,07908953 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,06226745 0,07903506 GO:0032313|regulation of Rab GTPase activity, ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,06226745 0,07898067 ! regulation of multicellular organism growth GO:0040014 21 21 0,000 0,06226745 0,07892635 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,06226745 0,07887211 ! regulation of proteolysis GO:0030162 21 21 0,000 0,06226745 0,07881794 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 0,000 0,06226745 0,07876384 ! RNA export from nucleus GO:0006405 22 22 0,000 0,06513848 0,08233897 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,06513848 0,08228254 ! regulation of ion transport GO:0043269 22 22 0,000 0,06513848 0,08222618 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 0,000 0,06513848 0,0821699 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! hormone-mediated signaling GO:0009755 22 22 0,000 0,06513848 0,08211369 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,06513848 0,08205757 ! ovulation cycle process GO:0022602 22 22 0,000 0,06513848 0,08200152 ! spindle organization GO:0007051 22 22 0,000 0,06513848 0,08194554 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,06513848 0,08188964 ! cell chemotaxis GO:0060326 23 22 0,000 0,06513848 0,08183382 GO:0030595|leukocyte chemotaxis, ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,06513848 0,08177808 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,06513848 0,08172241 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,06513848 0,08166682 ! biopolymer methylation GO:0043414 22 22 0,000 0,06513848 0,0816113 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 0,000 0,06513848 0,08155586 ! detection of external stimulus GO:0009581 23 22 0,000 0,06513848 0,08150049 ! neuron migration GO:0001764 22 22 0,000 0,06513848 0,0814452 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,06513848 0,08138998 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,06513848 0,08133484 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 0,000 0,06513848 0,08127977 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,06513848 0,08122478 ! aerobic respiration GO:0009060 22 22 0,000 0,06513848 0,08116986 ! cytokine production GO:0001816 22 22 0,000 0,06513848 0,08111501 ! cytokinesis GO:0000910 23 22 0,000 0,06513848 0,08106024 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,06513848 0,08100555 ! response to hydrogen peroxide GO:0042542 24 23 0,000 0,06800114 0,08450849 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,06800114 0,08445155 ! viral infectious cycle GO:0019058 23 23 0,000 0,06800114 0,08439468 ! regulation of hormone secretion GO:0046883 23 23 0,000 0,06800114 0,08433788 ! response to estrogen stimulus GO:0043627 23 23 0,000 0,06800114 0,08428117 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,06800114 0,08422452 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,06800114 0,08416796 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,06800114 0,08411147 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,06800114 0,08405506 ! endocrine system development GO:0035270 23 23 0,000 0,06800114 0,08399872 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,06800114 0,08394246 ! female gonad development GO:0008585 23 23 0,000 0,06800114 0,08388627 ! lipid homeostasis GO:0055088 23 23 0,000 0,06800114 0,08383016 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,06800114 0,08377413 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,06800114 0,08371817 ! gliogenesis GO:0042063 24 24 0,000 0,07085544 0,08717395 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,07085544 0,0871158 ! cellular amino acid biosynthetic process GO:0008652 24 24 0,000 0,07085544 0,08705772 ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,07085544 0,08699972 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,07085544 0,0869418 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,07085544 0,08688395 ! ovulation cycle GO:0042698 24 24 0,000 0,07085544 0,08682618 ! fertilization GO:0009566 25 24 0,000 0,07085544 0,08676849 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,07085544 0,08671088 ! androgen receptor signaling pathway GO:0030521 24 24 0,000 0,07085544 0,08665334 ! epithelial tube morphogenesis GO:0060562 25 24 0,000 0,07085544 0,08659587 ! glucan metabolic process GO:0044042 25 24 0,000 0,07085544 0,08653849 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,07370142 0,08995478 ! negative regulation of secretion GO:0051048 26 25 0,000 0,07370142 0,08989525 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,07370142 0,08983579 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,07370142 0,08977642 ! cellular component disassembly GO:0022411 26 25 0,000 0,07370142 0,08971712 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,07370142 0,0896579 ! development of primary female sexual characteristics GO:0046545 25 25 0,000 0,07370142 0,08959876 GO:0046660|female sex differentiation, ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,07370142 0,0895397 ! excretion GO:0007588 25 25 0,000 0,07370142 0,08948071 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,07370142 0,0894218 ! gastrulation GO:0007369 25 25 0,000 0,07370142 0,08936297 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,07370142 0,08930422 ! regulation of endocytosis GO:0030100 25 25 0,000 0,07370142 0,08924554 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,07370142 0,08918695 ! positive regulation of cytokine production GO:0001819 25 25 0,000 0,07370142 0,08912842 ! positive regulation of defense response GO:0031349 26 26 0,000 0,0765391 0,09249938 ! glycolysis GO:0006096 26 26 0,000 0,0765391 0,09243877 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,0765391 0,09237823 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,0765391 0,09231777 ! negative regulation of cell migration GO:0030336 26 26 0,000 0,0765391 0,09225739 ! cellular defense response GO:0006968 26 26 0,000 0,0765391 0,0921971 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,0765391 0,09213688 ! regulation of protein secretion GO:0050708 26 26 0,000 0,0765391 0,09207673 ! germ cell development GO:0007281 27 26 0,000 0,0765391 0,09201667 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,0765391 0,09195669 GO:0035150|regulation of tube size, ! pigment metabolic process GO:0042440 26 26 0,000 0,0765391 0,09189678 ! chloride transport GO:0006821 27 27 0,000 0,07936849 0,09523186 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,07936849 0,0951699 ! energy reserve metabolic process GO:0006112 28 27 0,000 0,07936849 0,09510802 ! learning or memory GO:0007611 28 27 0,000 0,07936849 0,09504622 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,07936849 0,0949845 ! mesenchymal cell development GO:0014031 29 27 0,000 0,07936849 0,09492286 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! inner ear development GO:0048839 27 27 0,000 0,07936849 0,09486131 ! defense response to bacterium GO:0042742 27 27 0,000 0,07936849 0,09479983 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,07936849 0,09473843 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,07936849 0,09467711 ! cell growth GO:0016049 27 27 0,000 0,07936849 0,09461587 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,08218963 0,09791564 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,08218963 0,09785238 GO:0007254|JNK cascade, ! neuromuscular process GO:0050905 28 28 0,000 0,08218963 0,09778921 ! carbohydrate transport GO:0008643 28 28 0,000 0,08218963 0,09772612 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,08218963 0,09766311 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,08218963 0,09760019 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,08218963 0,09753734 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,08218963 0,09747458 ! developmental growth GO:0048589 28 28 0,000 0,08218963 0,09741189 ! cartilage development GO:0051216 29 28 0,000 0,08218963 0,09734929 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,08500254 0,10061636 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,08500254 0,10055178 ! leukocyte migration GO:0050900 30 29 0,000 0,08500254 0,10048728 ! branching morphogenesis of a tube GO:0048754 29 29 0,000 0,08500254 0,10042287 ! antigen processing and presentation GO:0019882 29 29 0,000 0,08500254 0,10035853 ! DNA-dependent DNA replication GO:0006261 29 29 0,000 0,08500254 0,10029428 ! tRNA processing GO:0008033 29 29 0,000 0,08500254 0,10023012 ! regulation of gene expression, epigenetic GO:0040029 29 29 0,000 0,08500254 0,10016603 ! adult behavior GO:0030534 30 29 0,000 0,08500254 0,10010203 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,08500254 0,10003811 ! transition metal ion transport GO:0000041 31 30 0,000 0,08780723 0,10327296 ! RNA catabolic process GO:0006401 30 30 0,000 0,08780723 0,10320709 ! response to reactive oxygen species GO:0000302 31 30 0,000 0,08780723 0,10314131 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,08780723 0,10307562 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,08780723 0,10301001 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,08780723 0,10294448 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,08780723 0,10287903 ! positive regulation of response to external stimulus GO:0032103 30 30 0,000 0,08780723 0,10281367 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,08780723 0,10274839 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,08780723 0,1026832 ! regulation of ossification GO:0030278 30 30 0,000 0,08780723 0,10261809 ! vascular process in circulatory system GO:0003018 31 30 0,000 0,08780723 0,10255306 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,08780723 0,10248811 GO:0019724|B cell mediated immunity, ! regulation of inflammatory response GO:0050727 30 30 0,000 0,08780723 0,10242324 ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,08780723 0,10235846 ! vesicle organization GO:0016050 30 30 0,000 0,08780723 0,10229376 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,08780723 0,10222914 ! establishment of organelle localization GO:0051656 31 30 0,000 0,08780723 0,1021646 ! membrane fusion GO:0006944 31 31 0,000 0,09060373 0,10535185 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,09060373 0,10528542 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,09060373 0,10521908 ! ion transmembrane transport GO:0034220 31 31 0,000 0,09060373 0,10515282 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,09060373 0,10508664 ! digestion GO:0007586 31 31 0,000 0,09060373 0,10502055 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,09060373 0,10495454 ! regulation of heart contraction GO:0008016 31 31 0,000 0,09060373 0,10488862 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,09060373 0,10482277 ! camera-type eye development GO:0043010 31 31 0,000 0,09060373 0,10475701 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,09060373 0,10469133 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,09060373 0,10462574 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,09060373 0,10456022 ! negative regulation of cell motion GO:0051271 31 31 0,000 0,09060373 0,10449479 ! cell redox homeostasis GO:0045454 32 32 0,000 0,09339207 0,10764327 ! glucose catabolic process GO:0006007 32 32 0,000 0,09339207 0,10757599 ! lipid modification GO:0030258 32 32 0,000 0,09339207 0,1075088 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,09339207 0,10744169 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,09339207 0,10737466 ! cell maturation GO:0048469 32 32 0,000 0,09339207 0,10730772 ! morphogenesis of a branching structure GO:0001763 32 32 0,000 0,09339207 0,10724086 ! nuclear export GO:0051168 32 32 0,000 0,09339207 0,10717409 ! kidney development GO:0001822 32 32 0,000 0,09339207 0,10710739 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,09339207 0,10704078 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,09617226 0,11015878 ! activation of protein kinase activity GO:0032147 35 33 0,000 0,09617226 0,11009036 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,09617226 0,11002202 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,09617226 0,10995377 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,09617226 0,1098856 ! regulation of neuron differentiation GO:0045664 34 33 0,000 0,09617226 0,10981752 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,09617226 0,10974952 ! regulation of actin filament length GO:0030832 34 34 0,000 0,09894434 0,11284308 ! regulation of bone remodeling GO:0046850 34 34 0,000 0,09894434 0,11277329 ! response to metal ion GO:0010038 34 34 0,000 0,09894434 0,11270359 ! ear development GO:0043583 34 34 0,000 0,09894434 0,11263398 ! muscle cell differentiation GO:0042692 35 34 0,000 0,09894434 0,11256445 ! cellular polysaccharide metabolic process GO:0044264 35 34 0,000 0,09894434 0,11249501 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,09894434 0,11242565 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,09894434 0,11235638 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,09894434 0,1122872 ! secondary metabolic process GO:0019748 34 34 0,000 0,09894434 0,1122181 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,09894434 0,11214908 ! detection of stimulus GO:0051606 36 34 0,000 0,09894434 0,11208015 ! acute inflammatory response GO:0002526 35 35 0,000 0,10170831 0,1151403 ! regulation of cellular component size GO:0032535 35 35 0,000 0,10170831 0,11506962 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,10170831 0,11499903 ! mesoderm development GO:0007498 35 35 0,000 0,10170831 0,11492852 ! multicellular organism reproduction GO:0032504 36 35 0,000 0,10170831 0,1148581 GO:0048609|reproductive process in a multicellular organism, ! regulation of cell morphogenesis GO:0022604 38 35 0,000 0,10170831 0,11478776 ! regulation of tissue remodeling GO:0034103 35 35 0,000 0,10170831 0,11471751 ! inorganic anion transport GO:0015698 35 35 0,000 0,10170831 0,11464735 ! response to steroid hormone stimulus GO:0048545 35 35 0,000 0,10170831 0,11457727 ! regulation of immune effector process GO:0002697 35 35 0,000 0,10170831 0,11450728 ! hydrogen transport GO:0006818 36 36 0,000 0,10446421 0,11753818 GO:0015992|proton transport, ! response to inorganic substance GO:0010035 36 36 0,000 0,10446421 0,11746646 ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,10446421 0,11739484 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 0,000 0,10446421 0,1173233 ! regulation of mitosis GO:0007088 37 36 0,000 0,10446421 0,11725185 GO:0051783|regulation of nuclear division, ! embryonic limb morphogenesis GO:0030326 36 36 0,000 0,10446421 0,11718048 GO:0035113|embryonic appendage morphogenesis, ! female pregnancy GO:0007565 37 36 0,000 0,10446421 0,11710921 ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,10446421 0,11703802 ! positive regulation of organelle organization GO:0010638 36 36 0,000 0,10446421 0,11696691 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,10446421 0,11689589 ! integrin-mediated signaling pathway GO:0007229 36 36 0,000 0,10446421 0,11682496 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,10446421 0,11675411 ! gonad development GO:0008406 36 36 0,000 0,10446421 0,11668335 ! activation of immune response GO:0002253 36 36 0,000 0,10446421 0,11661268 ! coagulation GO:0050817 39 36 0,000 0,10446421 0,11654209 GO:0007596|blood coagulation, ! meiosis GO:0007126 37 37 0,000 0,10721205 0,11953528 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of protein kinase activity GO:0006469 37 37 0,000 0,10721205 0,11946301 ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,10721205 0,11939082 ! eye development GO:0001654 37 37 0,000 0,10721205 0,11931873 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,10721205 0,11924672 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,10721205 0,1191748 ! regulation of Rho protein signal transduction GO:0035023 37 37 0,000 0,10721205 0,11910296 ! adaptive immune response GO:0002250 37 37 0,000 0,10721205 0,11903121 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of secretion GO:0051047 39 38 0,000 0,10995187 0,12199957 ! neurotransmitter transport GO:0006836 40 38 0,000 0,10995187 0,12192617 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,10995187 0,12185285 ! exocytosis GO:0006887 40 38 0,000 0,10995187 0,12177962 ! negative regulation of kinase activity GO:0033673 38 38 0,000 0,10995187 0,12170648 ! cell-matrix adhesion GO:0007160 39 38 0,000 0,10995187 0,12163343 ! urogenital system development GO:0001655 38 38 0,000 0,10995187 0,12156046 ! hexose catabolic process GO:0019320 38 38 0,000 0,10995187 0,12148758 ! RNA elongation GO:0006354 38 38 0,000 0,10995187 0,12141479 ! meiotic cell cycle GO:0051321 38 38 0,000 0,10995187 0,12134209 ! regulation of neurological system process GO:0031644 38 38 0,000 0,10995187 0,12126947 ! steroid hormone receptor signaling pathway GO:0030518 38 38 0,000 0,10995187 0,12119694 ! regulation of homeostatic process GO:0032844 38 38 0,000 0,10995187 0,1211245 ! hemostasis GO:0007599 42 39 0,000 0,11268367 0,12405974 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,11268367 0,12398568 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,11268367 0,1239117 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,11268367 0,12383781 ! regulation of MAPKKK cascade GO:0043408 41 39 0,000 0,11268367 0,12376401 ! positive regulation of T cell activation GO:0050870 39 39 0,000 0,11268367 0,1236903 ! developmental maturation GO:0021700 39 39 0,000 0,11268367 0,12361667 ! limb development GO:0060173 39 39 0,000 0,11268367 0,12354313 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! DNA catabolic process GO:0006308 41 40 0,000 0,11540749 0,12645422 ! negative regulation of transferase activity GO:0051348 40 40 0,000 0,11540749 0,12637909 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 0,000 0,11540749 0,12630404 ! myeloid cell differentiation GO:0030099 42 40 0,000 0,11540749 0,12622908 ! organelle localization GO:0051640 41 40 0,000 0,11540749 0,12615421 ! amine catabolic process GO:0009310 42 41 0,000 0,11812334 0,12904643 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,11812334 0,12896998 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,11812334 0,12889362 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,11812334 0,12881735 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,11812334 0,12874117 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,11812334 0,12866509 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,12083126 0,13153692 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,12083126 0,13145927 ! cell-substrate adhesion GO:0031589 43 42 0,000 0,12083126 0,13138171 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,12083126 0,13130425 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! forebrain development GO:0030900 43 42 0,000 0,12083126 0,13122687 ! one-carbon metabolic process GO:0006730 42 42 0,000 0,12083126 0,13114959 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 0,000 0,12083126 0,1310724 ! reproductive structure development GO:0048608 43 43 0,000 0,12353125 0,13392241 ! alcohol catabolic process GO:0046164 43 43 0,000 0,12353125 0,13384368 ! homeostasis of number of cells GO:0048872 44 43 0,000 0,12353125 0,13376504 ! humoral immune response GO:0006959 44 44 0,000 0,12622334 0,13659989 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 0,000 0,12622334 0,13651973 ! negative regulation of organelle organization GO:0010639 45 44 0,000 0,12622334 0,13643966 ! vitamin metabolic process GO:0006766 44 44 0,000 0,12622334 0,13635968 ! positive regulation of lymphocyte activation GO:0051251 44 44 0,000 0,12622334 0,1362798 ! amine biosynthetic process GO:0009309 46 45 0,000 0,12890756 0,13909639 ! homophilic cell adhesion GO:0007156 45 45 0,000 0,12890756 0,139015 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,12890756 0,1389337 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 0,000 0,12890756 0,1388525 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,12890756 0,1387714 ! Wnt receptor signaling pathway GO:0016055 46 45 0,000 0,12890756 0,13869039 ! protein processing GO:0016485 45 45 0,000 0,12890756 0,13860947 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,13158392 0,14140476 ! tube morphogenesis GO:0035239 47 46 0,000 0,13158392 0,14132236 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 0,000 0,13158392 0,14124005 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,13158392 0,14115784 ! positive regulation of ligase activity GO:0051351 47 46 0,000 0,13158392 0,14107572 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,13425245 0,14385306 ! regulation of blood pressure GO:0008217 48 47 0,000 0,13425245 0,14376948 ! rhythmic process GO:0048511 47 47 0,000 0,13425245 0,14368599 ! calcium ion transport GO:0006816 48 48 0,000 0,13691317 0,14644862 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 0,000 0,13691317 0,14636368 ! regulation of cell cycle process GO:0010564 50 48 0,000 0,13691317 0,14627883 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,13691317 0,14619408 ! DNA recombination GO:0006310 48 48 0,000 0,13691317 0,14610943 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,1395661 0,14885436 ! divalent metal ion transport GO:0070838 49 49 0,000 0,1395661 0,14876826 ! response to nutrient GO:0007584 49 49 0,000 0,1395661 0,14868227 ! response to bacterium GO:0009617 50 49 0,000 0,1395661 0,14859638 ! regulation of ligase activity GO:0051340 50 49 0,000 0,1395661 0,14851058 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,1395661 0,14842489 ! positive regulation of cell activation GO:0050867 49 49 0,000 0,1395661 0,14833929 GO:0002696|positive regulation of leukocyte activation, ! regulation of defense response GO:0031347 50 50 0,000 0,14221127 0,15106361 ! chromatin assembly GO:0031497 50 50 0,000 0,14221127 0,15097659 GO:0006334|nucleosome assembly, ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,14221127 0,15088968 ! transcription initiation GO:0006352 50 50 0,000 0,14221127 0,15080286 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,14484868 0,15351129 ! positive regulation of immune response GO:0050778 51 51 0,000 0,14484868 0,15342306 ! rRNA metabolic process GO:0016072 51 51 0,000 0,14484868 0,15333494 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,14484868 0,15324692 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,14484868 0,15315899 ! protein maturation GO:0051604 51 51 0,000 0,14484868 0,15307117 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,14747838 0,15576083 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,14747838 0,15567162 ! regulation of body fluid levels GO:0050878 55 52 0,000 0,14747838 0,15558251 ! sodium ion transport GO:0006814 53 53 0,000 0,15010037 0,158258 ! tRNA metabolic process GO:0006399 53 53 0,000 0,15010037 0,15816751 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,15010037 0,15807713 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,15010037 0,15798685 ! protein amino acid dephosphorylation GO:0006470 55 54 0,000 0,15271468 0,16064678 ! response to virus GO:0009615 54 54 0,000 0,15271468 0,16055514 ! hormone metabolic process GO:0042445 55 54 0,000 0,15271468 0,1604636 ! sulfur metabolic process GO:0006790 55 54 0,000 0,15271468 0,16037217 ! negative regulation of multicellular organismal process GO:0051241 55 54 0,000 0,15271468 0,16028084 ! nucleosome organization GO:0034728 55 55 0,000 0,15532133 0,16292385 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,15532133 0,16283118 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 55 55 0,000 0,15532133 0,16273861 ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,15792034 0,16536772 ! ATP metabolic process GO:0046034 57 57 0,000 0,16051173 0,16798588 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,16051173 0,16789054 ! innate immune response GO:0045087 58 58 0,000 0,16309553 0,17049635 ! dephosphorylation GO:0016311 60 59 0,000 0,16567176 0,1730913 ! sterol metabolic process GO:0016125 59 59 0,000 0,16567176 0,17299323 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,16567176 0,17289527 ! immune effector process GO:0002252 59 59 0,000 0,16567176 0,17279742 ! potassium ion transport GO:0006813 60 60 0,000 0,16824042 0,17537732 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 0,000 0,16824042 0,17527818 ! protein polymerization GO:0051258 65 60 0,000 0,16824042 0,17517915 ! cellular respiration GO:0045333 62 61 0,000 0,17080156 0,1777455 ! proteasomal protein catabolic process GO:0010498 62 61 0,000 0,17080156 0,17764519 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,17080156 0,177545 GO:0016054|organic acid catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 0,000 0,17080156 0,17744491 ! lipid transport GO:0006869 62 62 0,000 0,17335519 0,1799964 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,17335519 0,17989505 ! morphogenesis of an epithelium GO:0002009 63 62 0,000 0,17335519 0,17979381 GO:0060429|epithelium development, ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,17335519 0,17969269 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,17335519 0,17959169 ! regulation of secretion GO:0051046 65 63 0,000 0,17590132 0,18212704 ! negative regulation of cellular component organization GO:0051129 65 63 0,000 0,17590132 0,18202478 ! glucose metabolic process GO:0006006 63 63 0,000 0,17590132 0,18192263 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,17590132 0,1818206 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,17590132 0,18171868 ! glycerolipid metabolic process GO:0046486 65 64 0,000 0,17843998 0,18423803 ! regulation of response to external stimulus GO:0032101 65 64 0,000 0,17843998 0,18413488 ! regulation of cytoskeleton organization GO:0051493 66 64 0,000 0,17843998 0,18403184 ! positive regulation of cellular component organization GO:0051130 65 65 0,000 0,1809712 0,18653799 ! regulation of hormone levels GO:0010817 66 65 0,000 0,1809712 0,18643372 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,18349499 0,18892808 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,18349499 0,18882259 ! polysaccharide metabolic process GO:0005976 69 66 0,000 0,18349499 0,18871722 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,18601136 0,19119852 ! muscle contraction GO:0006936 67 67 0,000 0,18601136 0,19109194 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,18852036 0,19356157 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,18852036 0,19345379 ! sensory perception of sound GO:0007605 71 69 0,000 0,19102198 0,1959118 GO:0050954|sensory perception of mechanical stimulus, ! growth GO:0040007 70 70 0,000 0,19351626 0,19835955 ! carboxylic acid biosynthetic process GO:0046394 70 70 0,000 0,19351626 0,19824929 GO:0016053|organic acid biosynthetic process, ! translational elongation GO:0006414 71 71 0,000 0,19600322 0,20068551 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,19600322 0,20057408 ! ribosome biogenesis GO:0042254 71 71 0,000 0,19600322 0,20046278 ! negative regulation of signal transduction GO:0009968 71 71 0,000 0,19600322 0,20035159 ! secretion by cell GO:0032940 75 72 0,000 0,19848286 0,20277379 ! muscle system process GO:0003012 72 72 0,000 0,19848286 0,20266145 ! sensory organ development GO:0007423 72 72 0,000 0,19848286 0,20254924 ! regulation of cytokine production GO:0001817 72 72 0,000 0,19848286 0,20243714 ! electron transport chain GO:0022900 75 74 0,000 0,20342033 0,20735822 ! coenzyme metabolic process GO:0006732 75 74 0,000 0,20342033 0,2072436 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,20587819 0,20963177 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,20587819 0,20951601 ! negative regulation of cell communication GO:0010648 76 76 0,000 0,20832882 0,21189294 ! positive regulation of multicellular organismal process GO:0051240 76 76 0,000 0,20832882 0,21177607 ! microtubule-based movement GO:0007018 82 78 0,000 0,2132085 0,21661701 ! regulation of immune response GO:0050776 78 78 0,000 0,2132085 0,21649766 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,21805952 0,22130159 ! lipid catabolic process GO:0016042 82 81 0,000 0,22047433 0,22362917 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,22528268 0,22838062 ! ncRNA processing GO:0034470 83 83 0,000 0,22528268 0,22825507 ! cellular amino acid derivative metabolic process GO:0006575 87 84 0,000 0,22767624 0,23055347 ! positive regulation of cell differentiation GO:0045597 87 85 0,000 0,23006276 0,23284221 ! positive regulation of response to stimulus GO:0048584 86 85 0,000 0,23006276 0,23271442 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,23244226 0,23499237 GO:0006644|phospholipid metabolic process, ! hexose metabolic process GO:0019318 87 86 0,000 0,23244226 0,23486353 ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,23718026 0,23951957 ! chemotaxis GO:0006935 90 89 0,000 0,2395388 0,2417689 GO:0042330|taxis, ! regulation of Ras protein signal transduction GO:0046578 90 90 0,000 0,2418904 0,24400876 ! brain development GO:0007420 91 90 0,000 0,2418904 0,24387527 ! DNA replication GO:0006260 91 91 0,000 0,24423507 0,24610455 ! visual perception GO:0007601 93 92 0,000 0,24657283 0,24832444 GO:0050953|sensory perception of light stimulus, ! fatty acid metabolic process GO:0006631 93 92 0,000 0,24657283 0,24818881 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 0,000 0,24657283 0,24805334 ! positive regulation of immune system process GO:0002684 92 92 0,000 0,24657283 0,24791801 ! tissue morphogenesis GO:0048729 94 93 0,000 0,2489037 0,25012515 ! regulation of response to stress GO:0080134 97 94 0,000 0,25122771 0,25232298 ! epidermis development GO:0008544 94 94 0,000 0,25122771 0,25218555 ! cofactor metabolic process GO:0051186 95 94 0,000 0,25122771 0,25204826 ! endocytosis GO:0006897 99 98 0,000 0,26045542 0,26116395 GO:0010324|membrane invagination, ! glycoprotein metabolic process GO:0009100 99 98 0,000 0,26045542 0,26102194 ! blood circulation GO:0008015 99 98 0,000 0,26045542 0,26088008 GO:0003013|circulatory system process, ! regulation of system process GO:0044057 98 98 0,000 0,26045542 0,26073837 ! ectoderm development GO:0007398 99 99 0,000 0,26274537 0,26288801 ! response to other organism GO:0051707 101 100 0,000 0,26502857 0,26502857