pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6334-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! spindle assembly GO:0051225 5 5 3,000 1,583E-10 3,641E-07 ! natural killer cell mediated immunity GO:0002228 13 9 3,000 3,961E-09 4,555E-06 GO:0042267|natural killer cell mediated cytotoxicity, ! leukocyte mediated cytotoxicity GO:0001909 17 11 3,000 1,034E-08 7,926E-06 ! cell killing GO:0001906 20 14 3,000 3,119E-08 1,793E-05 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 8,043E-08 3,7E-05 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 7,696E-07 2,95E-04 ! spindle organization GO:0007051 37 30 3,000 8,299E-07 2,727E-04 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 1,006E-06 2,893E-04 ! receptor clustering GO:0043113 15 9 2,000 1,152E-06 2,945E-04 ! microtubule cytoskeleton organization GO:0000226 120 84 4,000 1,894E-06 4,355E-04 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 2,008E-06 4,199E-04 ! positive regulation of bone mineralization GO:0030501 19 13 2,000 3,897E-06 7,469E-04 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 4,951E-06 8,76E-04 GO:0060675|ureteric bud morphogenesis, ! positive regulation of biomineral formation GO:0070169 20 14 2,000 4,951E-06 8,134E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 7,289E-06 1,118E-03 ! signal complex assembly GO:0007172 29 17 2,000 9,202E-06 1,323E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 9,202E-06 1,245E-03 ! neuromuscular junction development GO:0007528 23 17 2,000 9,202E-06 1,176E-03 ! positive regulation of ossification GO:0045778 30 19 2,000 1,307E-05 1,582E-03 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,307E-05 1,503E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,535E-05 1,681E-03 ! positive regulation of osteoblast differentiation GO:0045669 33 20 2,000 1,535E-05 1,604E-03 ! lymphocyte mediated immunity GO:0002449 88 62 3,000 1,595E-05 1,595E-03 ! positive regulation of bone remodeling GO:0046852 33 21 2,000 1,787E-05 1,713E-03 GO:0034105|positive regulation of tissue remodeling, ! dendrite development GO:0016358 35 21 2,000 1,787E-05 1,644E-03 ! regulation of bone mineralization GO:0030500 29 21 2,000 1,787E-05 1,581E-03 ! ureteric bud development GO:0001657 32 22 2,000 2,066E-05 1,76E-03 ! regulation of biomineral formation GO:0070167 31 23 2,000 2,372E-05 1,948E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 2,706E-05 2,146E-03 ! receptor metabolic process GO:0043112 37 24 2,000 2,706E-05 2,075E-03 ! regulation of osteoblast differentiation GO:0045667 37 24 2,000 2,706E-05 2,008E-03 ! leukocyte mediated immunity GO:0002443 99 71 3,000 2,735E-05 1,966E-03 ! BMP signaling pathway GO:0030509 40 28 2,000 4,35E-05 3,032E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 5,882E-05 3,979E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 5,882E-05 3,865E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 5,882E-05 3,758E-03 ! protein amino acid prenylation GO:0018346 9 5 1,000 5,882E-05 3,656E-03 ! metanephros development GO:0001656 58 31 2,000 5,938E-05 3,594E-03 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 7,865E-05 4,638E-03 ! male sex determination GO:0030238 9 6 1,000 8,809E-05 5,065E-03 ! protein prenylation GO:0018342 10 6 1,000 8,809E-05 4,942E-03 ! hormone-mediated signaling GO:0009755 49 36 2,000 9,352E-05 5,121E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,191E-04 6,37E-03 ! synapse organization GO:0050808 55 39 2,000 1,191E-04 6,225E-03 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 1,000 1,231E-04 6,294E-03 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 1,000 1,231E-04 6,157E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,231E-04 6,026E-03 ! microtubule bundle formation GO:0001578 8 7 1,000 1,231E-04 5,9E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 1,231E-04 5,78E-03 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 1,488E-04 6,846E-03 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 1,597E-04 7,203E-03 ! response to insulin stimulus GO:0032868 63 43 2,000 1,597E-04 7,064E-03 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 1,597E-04 6,931E-03 ! keratinocyte proliferation GO:0043616 12 8 1,000 1,639E-04 6,982E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,639E-04 6,855E-03 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,639E-04 6,733E-03 GO:0045685|regulation of glial cell differentiation, ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,639E-04 6,614E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 1,639E-04 6,5E-03 ! regulation of ossification GO:0030278 71 46 2,000 1,955E-04 7,619E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 2,104E-04 8,066E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 2,104E-04 7,934E-03 ! regulation of glycolysis GO:0006110 15 9 1,000 2,104E-04 7,806E-03 ! lung alveolus development GO:0048286 17 9 1,000 2,104E-04 7,682E-03 ! motor axon guidance GO:0008045 14 9 1,000 2,104E-04 7,562E-03 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 2,104E-04 7,446E-03 ! localization within membrane GO:0051668 15 9 1,000 2,104E-04 7,333E-03 ! heart morphogenesis GO:0003007 65 48 2,000 2,219E-04 7,619E-03 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 2,36E-04 7,983E-03 ! skeletal muscle fiber development GO:0048741 73 50 2,000 2,506E-04 8,355E-03 ! positive regulation of growth GO:0045927 67 50 2,000 2,506E-04 8,235E-03 ! negative regulation of blood pressure GO:0045776 22 10 1,000 2,626E-04 8,508E-03 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,626E-04 8,389E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,626E-04 8,275E-03 GO:0043470|regulation of carbohydrate catabolic process, ! cardiac cell differentiation GO:0035051 16 10 1,000 2,626E-04 8,163E-03 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 2,626E-04 8,054E-03 ! muscle fiber development GO:0048747 74 51 2,000 2,659E-04 8,045E-03 ! positive regulation of cell migration GO:0030335 92 51 2,000 2,659E-04 7,941E-03 ! regulation of bone remodeling GO:0046850 90 53 2,000 2,98E-04 8,788E-03 ! kidney development GO:0001822 90 53 2,000 2,98E-04 8,677E-03 ! regulation of tissue remodeling GO:0034103 91 54 2,000 3,15E-04 9,057E-03 ! virus-host interaction GO:0019048 17 11 1,000 3,205E-04 9,1E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 3,205E-04 8,989E-03 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 3,205E-04 8,881E-03 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 3,205E-04 8,775E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 3,205E-04 8,672E-03 GO:0042130|negative regulation of T cell proliferation, ! positive regulation of cell motion GO:0051272 99 56 2,000 3,509E-04 9,383E-03 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 3,697E-04 9,774E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 3,84E-04 0,01003593 ! positive regulation of cell growth GO:0030307 16 12 1,000 3,84E-04 9,923E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 3,84E-04 9,813E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! urogenital system development GO:0001655 101 61 2,000 4,516E-04 0,0114153 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,531E-04 0,01132726 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 4,531E-04 0,01120546 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,278E-04 0,01291377 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 5,278E-04 0,01277783 GO:0031114|regulation of microtubule depolymerization, ! negative regulation of caspase activity GO:0043154 20 14 1,000 5,278E-04 0,01264473 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 5,278E-04 0,01251437 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 5,278E-04 0,01238668 ! positive regulation of cell size GO:0045793 20 15 1,000 6,08E-04 0,01412587 ! skin development GO:0043588 25 15 1,000 6,08E-04 0,01398461 ! lipid phosphorylation GO:0046834 23 15 1,000 6,08E-04 0,01384615 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 6,08E-04 0,0137104 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 6,08E-04 0,01357729 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 6,08E-04 0,01344674 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 2,000 6,765E-04 0,01481759 ! regulation of catabolic process GO:0009894 106 70 2,000 6,765E-04 0,0146778 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 6,938E-04 0,01491352 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 6,938E-04 0,01477544 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 6,938E-04 0,01463988 ! tube morphogenesis GO:0035239 118 73 2,000 7,647E-04 0,01598838 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 7,851E-04 0,01626749 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 7,851E-04 0,01612224 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 7,851E-04 0,01597957 ! proximal/distal pattern formation GO:0009954 25 17 1,000 7,851E-04 0,0158394 ! positive regulation of DNA replication GO:0045740 29 18 1,000 8,818E-04 0,01763681 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 8,818E-04 0,01748477 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 8,818E-04 0,01733533 ! negative regulation of T cell activation GO:0050868 25 18 1,000 8,818E-04 0,01718842 ! regulation of DNA binding GO:0051101 119 77 2,000 8,932E-04 0,01726367 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 9,84E-04 0,01886095 GO:0010675|regulation of cellular carbohydrate metabolic process, ! sex determination GO:0007530 29 19 1,000 9,84E-04 0,01870507 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 9,84E-04 0,01855175 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 9,84E-04 0,01840092 ! protein stabilization GO:0050821 26 19 1,000 9,84E-04 0,01825253 ! regulation of vasoconstriction GO:0019229 31 21 1,000 1,205E-03 0,02216676 ! skeletal muscle tissue development GO:0007519 123 87 2,000 1,272E-03 0,02322534 GO:0060538|skeletal muscle organ development, ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 1,323E-03 0,02396203 ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 1,323E-03 0,02377483 ! protein tetramerization GO:0051262 39 22 1,000 1,323E-03 0,02359053 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 1,447E-03 0,02559853 ! myelination GO:0042552 35 23 1,000 1,447E-03 0,02540312 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 1,447E-03 0,02521067 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 1,447E-03 0,02502112 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 1,447E-03 0,02483439 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 1,447E-03 0,02465043 ! interaction with host GO:0051701 37 23 1,000 1,447E-03 0,02446918 ! negative regulation of catabolic process GO:0009895 34 23 1,000 1,447E-03 0,02429057 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 1,576E-03 0,02626578 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 1,576E-03 0,02607682 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 1,576E-03 0,02589056 ! regulation of binding GO:0051098 151 95 2,000 1,639E-03 0,02673502 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 1,71E-03 0,02770231 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 1,71E-03 0,02750858 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 1,74E-03 0,02778991 ! extracellular structure organization GO:0043062 156 99 2,000 1,845E-03 0,02925945 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 1,85E-03 0,02914314 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 1,85E-03 0,02894489 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 1,995E-03 0,03100088 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 1,995E-03 0,03079283 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of protein transport GO:0051224 49 27 1,000 1,995E-03 0,03058754 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 2,145E-03 0,03267131 ! mesoderm formation GO:0001707 46 28 1,000 2,145E-03 0,03245637 ! ensheathment of neurons GO:0007272 43 28 1,000 2,145E-03 0,03224423 GO:0008366|axon ensheathment, ! positive regulation of catabolic process GO:0009896 40 28 1,000 2,145E-03 0,03203485 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 2,3E-03 0,03413258 ! formation of primary germ layer GO:0001704 48 29 1,000 2,3E-03 0,03391378 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 2,461E-03 0,03604853 ! regulation of microtubule-based process GO:0032886 58 30 1,000 2,461E-03 0,03582038 ! negative regulation of cell activation GO:0050866 44 30 1,000 2,461E-03 0,03559509 ! mammary gland development GO:0030879 57 31 1,000 2,626E-03 0,03775324 ! odontogenesis GO:0042476 50 31 1,000 2,626E-03 0,03751875 ! maintenance of protein location in cell GO:0032507 60 31 1,000 2,626E-03 0,03728715 ! mesoderm morphogenesis GO:0048332 49 31 1,000 2,626E-03 0,0370584 ! peripheral nervous system development GO:0007422 53 32 1,000 2,797E-03 0,03922677 ! regulation of protein stability GO:0031647 48 32 1,000 2,797E-03 0,03898903 ! calcium-mediated signaling GO:0019722 50 32 1,000 2,797E-03 0,03875415 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 2,797E-03 0,03852209 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 2,973E-03 0,04069985 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 2,973E-03 0,04045902 ! carbohydrate homeostasis GO:0033500 39 33 1,000 2,973E-03 0,04022103 GO:0042593|glucose homeostasis, ! negative regulation of DNA binding GO:0043392 54 33 1,000 2,973E-03 0,03998582 ! positive regulation of cell development GO:0010720 54 33 1,000 2,973E-03 0,03975334 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 2,973E-03 0,03952356 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 3,34E-03 0,04414518 ! keratinocyte differentiation GO:0030216 47 35 1,000 3,34E-03 0,04389292 ! regulation of action potential in neuron GO:0019228 54 35 1,000 3,34E-03 0,04364353 ! maintenance of protein location GO:0045185 65 35 1,000 3,34E-03 0,04339695 ! negative regulation of binding GO:0051100 58 36 1,000 3,531E-03 0,04562049 ! regulation of T cell proliferation GO:0042129 58 38 1,000 3,927E-03 0,05046493 ! mesenchymal cell development GO:0014031 64 38 1,000 3,927E-03 0,05018457 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 1,000 3,927E-03 0,0499073 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 4,133E-03 0,05223461 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 4,133E-03 0,05194917 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 4,133E-03 0,05166684 ! induction of apoptosis by intracellular signals GO:0008629 67 40 1,000 4,344E-03 0,05400807 ! epidermal cell differentiation GO:0009913 53 40 1,000 4,344E-03 0,0537177 ! positive regulation of protein transport GO:0051222 55 40 1,000 4,344E-03 0,05343044 ! protein amino acid lipidation GO:0006497 62 41 1,000 4,56E-03 0,05578483 ! endosome transport GO:0016197 71 41 1,000 4,56E-03 0,05548967 ! positive regulation of DNA binding GO:0043388 57 41 1,000 4,56E-03 0,05519762 ! regulation of T cell differentiation GO:0045580 59 41 1,000 4,56E-03 0,05490863 ! regulation of JNK cascade GO:0046328 58 41 1,000 4,56E-03 0,05462265 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 4,78E-03 0,05696793 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 4,78E-03 0,05667428 ! positive regulation of binding GO:0051099 59 43 1,000 5,006E-03 0,05904217 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 5,006E-03 0,05874093 ! regulation of action potential GO:0001508 71 44 1,000 5,236E-03 0,06113061 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 5,236E-03 0,06082187 ! positive regulation of cell cycle GO:0045787 77 45 1,000 5,471E-03 0,06323256 ! lipoprotein biosynthetic process GO:0042158 67 45 1,000 5,471E-03 0,0629164 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 5,711E-03 0,06534733 ! response to UV GO:0009411 75 46 1,000 5,711E-03 0,06502383 ! negative regulation of immune system process GO:0002683 73 47 1,000 5,955E-03 0,06747427 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 5,955E-03 0,06714351 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! gastrulation GO:0007369 73 48 1,000 6,205E-03 0,06961277 ! regulation of DNA replication GO:0006275 75 48 1,000 6,205E-03 0,06927484 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 6,205E-03 0,06894018 ! regulation of angiogenesis GO:0045765 94 49 1,000 6,459E-03 0,07141721 ! regulation of intracellular transport GO:0032386 78 49 1,000 6,459E-03 0,0710755 ! cartilage development GO:0051216 70 49 1,000 6,459E-03 0,07073704 ! maintenance of location GO:0051235 84 49 1,000 6,459E-03 0,0704018 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 6,717E-03 0,07287598 ! lipid modification GO:0030258 73 50 1,000 6,717E-03 0,07253384 ! activation of phospholipase C activity GO:0007202 87 51 1,000 6,981E-03 0,07502501 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 1,000 6,981E-03 0,07467605 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 7,249E-03 0,07718358 ! regulation of phospholipase activity GO:0010517 90 54 1,000 7,798E-03 0,08265449 ! positive regulation of lipase activity GO:0060193 90 54 1,000 7,798E-03 0,08227534 ! mesoderm development GO:0007498 76 55 1,000 8,08E-03 0,08485839 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 8,366E-03 0,08746543 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 8,657E-03 0,09009591 ! negative regulation of kinase activity GO:0033673 100 58 1,000 8,952E-03 0,09274928 ! viral reproductive process GO:0022415 87 58 1,000 8,952E-03 0,09233336 ! activation of MAPK activity GO:0000187 84 59 1,000 9,252E-03 0,09499898 ! lung development GO:0030324 94 59 1,000 9,252E-03 0,09457676 ! actin filament organization GO:0007015 95 59 1,000 9,252E-03 0,09415828 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 9,556E-03 0,09682573 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 9,556E-03 0,09640105 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 9,556E-03 0,09598009 GO:0035113|embryonic appendage morphogenesis, ! regulation of cellular response to stress GO:0080135 85 61 1,000 9,865E-03 0,0986491 ! lipoprotein metabolic process GO:0042157 89 61 1,000 9,865E-03 0,09822204 ! negative regulation of transferase activity GO:0051348 105 61 1,000 9,865E-03 0,09779867 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,01017795 0,100469 ! respiratory tube development GO:0030323 99 62 1,000 0,01017795 0,10003965 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,01049537 0,10272061 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,01049537 0,10228535 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,01049537 0,10185377 ! viral reproduction GO:0016032 92 63 1,000 0,01049537 0,10142581 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01049537 0,10100143 ! negative regulation of cell size GO:0045792 108 64 1,000 0,01081715 0,10366432 ! appendage morphogenesis GO:0035107 93 64 1,000 0,01081715 0,10323418 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 1,000 0,01081715 0,10280759 ! regulation of caspase activity GO:0043281 97 65 1,000 0,01114327 0,10547123 ! appendage development GO:0048736 94 65 1,000 0,01114327 0,10503897 GO:0060173|limb development, ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,01114327 0,10461024 ! protein oligomerization GO:0051259 100 65 1,000 0,01114327 0,104185 ! axon guidance GO:0007411 99 66 1,000 0,0114737 0,10684012 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,0114737 0,10640931 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01180843 0,10907383 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01223941 0,11260254 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01223941 0,11215392 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01223941 0,11170887 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01223941 0,11126733 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01223941 0,11082927 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01223941 0,11039464 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01223941 0,10996341 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01223941 0,10953554 ! sleep GO:0030431 11 5 0,000 0,01223941 0,10911099 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01223941 0,10868971 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01223941 0,10827167 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01223941 0,10785684 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01223941 0,10744517 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01223941 0,10703663 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01223941 0,10663119 ! tongue development GO:0043586 6 5 0,000 0,01223941 0,10622881 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01223941 0,10582945 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01223941 0,10543309 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01223941 0,10503968 ! cobalt ion transport GO:0006824 9 5 0,000 0,01223941 0,1046492 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01223941 0,10426161 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01223941 0,10387688 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01223941 0,10349498 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01223941 0,10311588 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01223941 0,10273954 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01223941 0,10236594 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01223941 0,10199505 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01223941 0,10162684 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01223941 0,10126127 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01223941 0,10089833 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01223941 0,10053798 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01223941 0,10018019 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01223941 0,09982494 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01223941 0,09947221 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01223941 0,09912195 ! malate metabolic process GO:0006108 7 5 0,000 0,01223941 0,09877416 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01223941 0,09842879 ! behavioral response to pain GO:0048266 7 5 0,000 0,01223941 0,09808583 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01223941 0,09774526 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01223941 0,09740704 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01223941 0,09707115 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01223941 0,09673757 ! mating behavior GO:0007617 6 5 0,000 0,01223941 0,09640628 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01223941 0,09607725 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01223941 0,09575046 ! rhythmic behavior GO:0007622 12 5 0,000 0,01223941 0,09542588 ! copulation GO:0007620 7 5 0,000 0,01223941 0,09510349 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01223941 0,09478328 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01223941 0,09446522 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01223941 0,09414928 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01223941 0,09383545 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01223941 0,0935237 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01223941 0,09321402 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01223941 0,09290638 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01223941 0,09260077 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01223941 0,09229716 ! response to protozoan GO:0001562 9 5 0,000 0,01223941 0,09199554 ! lymph vessel development GO:0001945 7 5 0,000 0,01223941 0,09169588 ! endochondral ossification GO:0001958 12 5 0,000 0,01223941 0,09139816 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01223941 0,09110238 ! parathyroid gland development GO:0060017 8 5 0,000 0,01223941 0,0908085 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01223941 0,09051651 ! anagen GO:0042640 6 5 0,000 0,01223941 0,09022639 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01223941 0,08993813 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01223941 0,0896517 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01223941 0,08936709 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01223941 0,08908429 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01223941 0,08880326 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01223941 0,08852401 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01223941 0,0882465 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01223941 0,08797073 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01223941 0,08769668 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01223941 0,08742433 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01223941 0,08715367 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01223941 0,08688467 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01223941 0,08661734 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01223941 0,08635164 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01223941 0,08608757 ! ovulation GO:0030728 6 5 0,000 0,01223941 0,0858251 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01223941 0,08556424 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01223941 0,08530495 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01223941 0,08504723 ! response to pH GO:0009268 9 5 0,000 0,01223941 0,08479107 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01223941 0,08453644 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01223941 0,08428334 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01223941 0,08403174 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01223941 0,08378165 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01223941 0,08353304 ! polyol catabolic process GO:0046174 7 5 0,000 0,01223941 0,0832859 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01223941 0,08304022 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01223941 0,08279598 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01223941 0,08255318 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01223941 0,0823118 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01223941 0,08207182 ! urea metabolic process GO:0019627 6 5 0,000 0,01223941 0,08183324 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01223941 0,08159604 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01223941 0,08136021 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01223941 0,08112575 ! neutrophil activation GO:0042119 5 5 0,000 0,01223941 0,08089263 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01223941 0,08066084 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01223941 0,08043038 ! response to food GO:0032094 5 5 0,000 0,01223941 0,08020124 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01223941 0,07997339 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01223941 0,07974684 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01223941 0,07952157 ! forebrain neuron development GO:0021884 7 5 0,000 0,01223941 0,07929756 ! melanosome organization GO:0032438 7 5 0,000 0,01223941 0,07907482 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01223941 0,07885332 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01223941 0,07863306 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01223941 0,07841402 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01223941 0,07819621 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01223941 0,0779796 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01223941 0,07776418 ! nucleoside transport GO:0015858 6 5 0,000 0,01223941 0,07754996 ! nucleoside salvage GO:0043174 7 5 0,000 0,01223941 0,07733691 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01223941 0,07712503 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01223941 0,0769143 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01223941 0,07670473 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01223941 0,07649629 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01223941 0,07628898 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01223941 0,0760828 ! depyrimidination GO:0045008 8 5 0,000 0,01223941 0,07587772 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01223941 0,07567375 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01223941 0,07547087 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01223941 0,07526908 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01223941 0,07506836 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01223941 0,07486871 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01223941 0,07467012 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01223941 0,07447258 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01223941 0,07427608 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01223941 0,07408062 ! monocyte differentiation GO:0030224 8 5 0,000 0,01223941 0,07388618 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01223941 0,07369276 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01223941 0,07350035 ! centrosome duplication GO:0051298 5 5 0,000 0,01223941 0,07330894 ! response to UV-C GO:0010225 6 5 0,000 0,01223941 0,07311853 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01223941 0,0729291 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01223941 0,07274066 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01223941 0,07255318 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01223941 0,07236667 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01223941 0,07218111 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01223941 0,07199651 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01223941 0,07181284 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01223941 0,07163011 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01223941 0,07144831 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01223941 0,07126743 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01223941 0,07108746 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01223941 0,0709084 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01223941 0,07073024 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01223941 0,07055297 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01223941 0,07037659 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01223941 0,07020108 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01223941 0,07002645 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01223941 0,06985269 ! neural tube patterning GO:0021532 6 5 0,000 0,01223941 0,06967979 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01223941 0,06950774 ! histone demethylation GO:0016577 9 5 0,000 0,01223941 0,06933654 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01223941 0,06916618 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01223941 0,06899665 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01223941 0,06882796 ! enteric nervous system development GO:0048484 8 5 0,000 0,01223941 0,06866008 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01223941 0,06849303 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01223941 0,06832678 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01223941 0,06816134 ! transcription termination GO:0006353 8 5 0,000 0,01223941 0,0679967 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01223941 0,06783285 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01223941 0,06766979 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01223941 0,06750752 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01223941 0,06734601 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01223941 0,06718528 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01223941 0,06702532 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01223941 0,06686611 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01223941 0,06670766 ! apical protein localization GO:0045176 6 5 0,000 0,01223941 0,06654996 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01223941 0,06639301 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01223941 0,06623679 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01223941 0,0660813 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01223941 0,06592654 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01223941 0,06577251 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01223941 0,06561919 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01223941 0,06546659 ! glial cell migration GO:0008347 10 5 0,000 0,01223941 0,0653147 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01223941 0,06516351 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01223941 0,06501301 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01223941 0,06486321 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01223941 0,0647141 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01223941 0,06456567 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01223941 0,06441793 ! neural plate development GO:0001840 6 5 0,000 0,01223941 0,06427085 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01223941 0,06412445 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01223941 0,06397871 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01223941 0,06383364 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01223941 0,06368922 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01223941 0,06354545 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01223941 0,06340233 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01223941 0,06325985 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01223941 0,06311801 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01223941 0,06297681 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01223941 0,06283624 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01223941 0,06269629 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01223941 0,06255696 ! organ regeneration GO:0031100 7 5 0,000 0,01223941 0,06241826 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01223941 0,06228016 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01223941 0,06214268 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01223941 0,0620058 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01223941 0,06186953 GO:0055081|anion homeostasis, ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,01283815 0,06475385 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,01318984 0,06638211 ! steroid biosynthetic process GO:0006694 94 71 1,000 0,01318984 0,06623717 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,0135457 0,06787608 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,0135457 0,06772852 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,0135457 0,0675816 ! negative regulation of transport GO:0051051 116 73 1,000 0,01390573 0,06922768 ! regulation of blood pressure GO:0008217 107 73 1,000 0,01390573 0,06907816 ! mitochondrion organization GO:0007005 104 73 1,000 0,01390573 0,06892928 ! negative regulation of growth GO:0045926 123 75 1,000 0,01463819 0,07240396 ! tRNA transcription GO:0009304 11 6 0,000 0,01466967 0,07240395 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01466967 0,07224891 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01466967 0,07209453 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01466967 0,07194081 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01466967 0,07178774 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01466967 0,07163533 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01466967 0,07148356 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01466967 0,07133243 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01466967 0,07118194 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01466967 0,07103208 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01466967 0,07088286 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01466967 0,07073425 ! prostate gland development GO:0030850 9 6 0,000 0,01466967 0,07058627 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01466967 0,07043891 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01466967 0,07029216 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01466967 0,07014603 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01466967 0,0700005 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01466967 0,06985557 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01466967 0,06971124 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01466967 0,0695675 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01466967 0,06942436 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01466967 0,0692818 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01466967 0,06913983 ! neuron adhesion GO:0007158 9 6 0,000 0,01466967 0,06899844 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,01466967 0,06885763 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01466967 0,06871739 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01466967 0,06857772 ! signal peptide processing GO:0006465 8 6 0,000 0,01466967 0,06843862 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01466967 0,06830008 ! mRNA stabilization GO:0048255 15 6 0,000 0,01466967 0,0681621 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01466967 0,06802468 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01466967 0,0678878 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01466967 0,06775148 ! opsonization GO:0008228 8 6 0,000 0,01466967 0,06761571 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01466967 0,06748048 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01466967 0,06734579 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01466967 0,06721163 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01466967 0,06707801 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01466967 0,06694492 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01466967 0,06681235 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01466967 0,06668031 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01466967 0,06654879 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01466967 0,06641779 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01466967 0,06628731 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01466967 0,06615733 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01466967 0,06602786 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01466967 0,0658989 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01466967 0,06577045 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01466967 0,06564249 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01466967 0,06551503 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01466967 0,06538806 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01466967 0,06526158 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01466967 0,0651356 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01466967 0,06501009 ! thymic T cell selection GO:0045061 12 6 0,000 0,01466967 0,06488507 ! protein lipoylation GO:0009249 10 6 0,000 0,01466967 0,06476054 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01466967 0,06463647 ! pigment granule organization GO:0048753 11 6 0,000 0,01466967 0,06451289 ! drug transport GO:0015893 6 6 0,000 0,01466967 0,06438977 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01466967 0,06426712 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01466967 0,06414494 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01466967 0,06402322 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01466967 0,06390197 ! histidine metabolic process GO:0006547 6 6 0,000 0,01466967 0,06378117 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01466967 0,06366083 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01466967 0,06354094 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01466967 0,0634215 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01466967 0,06330251 ! adenohypophysis development GO:0021984 10 6 0,000 0,01466967 0,06318397 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01466967 0,06306587 ! hyperosmotic response GO:0006972 8 6 0,000 0,01466967 0,06294821 ! microtubule nucleation GO:0007020 10 6 0,000 0,01466967 0,06283099 ! ER overload response GO:0006983 7 6 0,000 0,01466967 0,0627142 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01466967 0,06259785 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01466967 0,06248192 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01466967 0,06236643 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01466967 0,06225136 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01466967 0,06213672 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01466967 0,0620225 ! response to dietary excess GO:0002021 7 6 0,000 0,01466967 0,0619087 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01466967 0,06179531 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01466967 0,06168234 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01466967 0,06156978 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01466967 0,06145763 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01466967 0,06134589 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01466967 0,06123455 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01466967 0,06112362 ! neuron apoptosis GO:0051402 8 6 0,000 0,01466967 0,06101309 ! organic alcohol transport GO:0015850 9 6 0,000 0,01466967 0,06090296 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01466967 0,06079322 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01466967 0,06068388 ! carnitine transport GO:0015879 8 6 0,000 0,01466967 0,06057494 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01466967 0,06046638 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01466967 0,06035821 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01466967 0,06025043 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01466967 0,06014303 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01466967 0,06003601 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01466967 0,05992938 ! parturition GO:0007567 12 6 0,000 0,01466967 0,05982312 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01466967 0,05971724 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01466967 0,05961173 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01466967 0,05950659 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01466967 0,05940183 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01466967 0,05929743 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01466967 0,0591934 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01466967 0,05908974 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01466967 0,05898643 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01466967 0,05888349 ! macrophage differentiation GO:0030225 10 6 0,000 0,01466967 0,0587809 ! astrocyte development GO:0014002 14 6 0,000 0,01466967 0,05867868 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01466967 0,0585768 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01466967 0,05847528 ! interaction with symbiont GO:0051702 8 6 0,000 0,01466967 0,05837412 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01466967 0,0582733 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01466967 0,05817283 ! eating behavior GO:0042755 6 6 0,000 0,01466967 0,0580727 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01466967 0,05797292 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01466967 0,05787348 ! response to copper ion GO:0046688 9 6 0,000 0,01466967 0,05777438 ! DNA topological change GO:0006265 8 6 0,000 0,01466967 0,05767562 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01466967 0,0575772 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01466967 0,05747911 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01466967 0,05738136 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01466967 0,05728394 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01466967 0,05718685 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01466967 0,05709008 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01466967 0,05699365 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01466967 0,05689754 ! gas homeostasis GO:0033483 11 6 0,000 0,01466967 0,05680175 ! hair follicle maturation GO:0048820 7 6 0,000 0,01466967 0,05670628 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01466967 0,05661114 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01466967 0,05651631 ! Schwann cell development GO:0014044 14 6 0,000 0,01466967 0,0564218 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01466967 0,05632761 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01466967 0,05623373 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01466967 0,05614016 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01466967 0,05604691 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01466967 0,05595396 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01466967 0,05586132 ! histone ubiquitination GO:0016574 7 6 0,000 0,01466967 0,05576899 ! regulation of meiosis GO:0040020 10 6 0,000 0,01466967 0,05567696 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01466967 0,05558524 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01466967 0,05549381 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01466967 0,05540269 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01466967 0,05531187 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01466967 0,05522134 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01466967 0,05513111 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01466967 0,05504117 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01466967 0,05495153 ! receptor internalization GO:0031623 9 6 0,000 0,01466967 0,05486218 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01466967 0,05477312 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01466967 0,05468434 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01466967 0,05459586 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01466967 0,05450766 ! protein deubiquitination GO:0016579 8 6 0,000 0,01466967 0,05441974 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01466967 0,05433211 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01466967 0,05424476 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01466967 0,05415769 ! axonal fasciculation GO:0007413 9 6 0,000 0,01466967 0,0540709 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01466967 0,05398438 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01466967 0,05389815 ! midbrain development GO:0030901 6 6 0,000 0,01466967 0,05381218 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01466967 0,0537265 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01466967 0,05364108 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01466967 0,05355593 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01466967 0,05347106 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01466967 0,05338645 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01466967 0,05330212 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01466967 0,05321804 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01466967 0,05313423 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01466967 0,05305069 ! adult feeding behavior GO:0008343 6 6 0,000 0,01466967 0,05296741 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01466967 0,05288439 ! blastocyst growth GO:0001832 15 6 0,000 0,01466967 0,05280163 ! pigment granule transport GO:0051904 12 6 0,000 0,01466967 0,05271912 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01466967 0,05263688 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01466967 0,05255489 ! catecholamine transport GO:0051937 7 6 0,000 0,01466967 0,05247316 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01466967 0,05239168 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01466967 0,05231045 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01466967 0,05222947 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01466967 0,05214875 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01466967 0,05206827 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01466967 0,05198804 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01466967 0,05190806 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01466967 0,05182832 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01466967 0,05174883 ! regulation of protein transport GO:0051223 114 76 1,000 0,01501058 0,05287034 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,01538704 0,05411345 ! gland development GO:0048732 148 77 1,000 0,01538704 0,05403084 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,01576756 0,05528261 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,01615211 0,05654469 ! regulation of lyase activity GO:0051339 133 79 1,000 0,01615211 0,05645875 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,01693323 0,0590993 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,01709409 0,05957032 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,01709409 0,0594802 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,01709409 0,05939035 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,01709409 0,05930077 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,01709409 0,05921146 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,01709409 0,05912242 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,01709409 0,05903365 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,01709409 0,05894514 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,01709409 0,0588569 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,01709409 0,05876892 ! reproductive behavior GO:0019098 12 7 0,000 0,01709409 0,05868121 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,01709409 0,05859376 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,01709409 0,05850656 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,01709409 0,05841963 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,01709409 0,05833295 ! oligopeptide transport GO:0006857 11 7 0,000 0,01709409 0,05824653 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,01709409 0,05816037 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,01709409 0,05807446 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,01709409 0,05798881 ! RNA methylation GO:0001510 11 7 0,000 0,01709409 0,0579034 ! pericardium development GO:0060039 8 7 0,000 0,01709409 0,05781825 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,01709409 0,05773335 ! fibril organization GO:0043206 13 7 0,000 0,01709409 0,0576487 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,01709409 0,05756429 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,01709409 0,05748013 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,01709409 0,05739622 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,01709409 0,05731255 ! lipoprotein transport GO:0042953 9 7 0,000 0,01709409 0,05722913 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,01709409 0,05714595 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,01709409 0,057063 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,01709409 0,0569803 ! estrogen metabolic process GO:0008210 14 7 0,000 0,01709409 0,05689784 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,01709409 0,05681562 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,01709409 0,05673364 ! chemosensory behavior GO:0007635 9 7 0,000 0,01709409 0,05665189 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,01709409 0,05657037 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,01709409 0,0564891 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,01709409 0,05640805 ! leukocyte degranulation GO:0043299 10 7 0,000 0,01709409 0,05632724 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,01709409 0,05624665 ! reflex GO:0060004 12 7 0,000 0,01709409 0,0561663 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,01709409 0,05608618 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,01709409 0,05600628 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,01709409 0,05592661 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,01709409 0,05584717 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,01709409 0,05576796 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,01709409 0,05568897 ! spinal cord patterning GO:0021511 7 7 0,000 0,01709409 0,0556102 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,01709409 0,05553165 ! adrenal gland development GO:0030325 17 7 0,000 0,01709409 0,05545333 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,01709409 0,05537523 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,01709409 0,05529734 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,01709409 0,05521968 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,01709409 0,05514223 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,01709409 0,055065 ! endosome organization GO:0007032 10 7 0,000 0,01709409 0,05498799 ! thyroid hormone generation GO:0006590 11 7 0,000 0,01709409 0,05491119 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,01709409 0,0548346 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,01709409 0,05475823 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,01709409 0,05468207 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,01709409 0,05460613 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,01709409 0,05453039 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,01709409 0,05445486 ! galactose metabolic process GO:0006012 10 7 0,000 0,01709409 0,05437954 ! vesicle fusion GO:0006906 15 7 0,000 0,01709409 0,05430443 ! intracellular pH reduction GO:0051452 10 7 0,000 0,01709409 0,05422953 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,01709409 0,05415484 ! organ growth GO:0035265 11 7 0,000 0,01709409 0,05408034 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,01709409 0,05400606 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,01709409 0,05393198 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,01709409 0,0538581 ! retinol metabolic process GO:0042572 9 7 0,000 0,01709409 0,05378442 ! behavioral fear response GO:0001662 13 7 0,000 0,01709409 0,05371094 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,01709409 0,05363767 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,01709409 0,05356459 ! rRNA modification GO:0000154 12 7 0,000 0,01709409 0,05349171 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,01709409 0,05341904 ! response to UV-B GO:0010224 11 7 0,000 0,01709409 0,05334655 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,01709409 0,05327427 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,01709409 0,05320218 ! intermediate filament organization GO:0045109 11 7 0,000 0,01709409 0,05313028 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,01709409 0,05305858 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,01709409 0,05298708 ! fibrinolysis GO:0042730 9 7 0,000 0,01709409 0,05291576 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,01709409 0,05284464 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,01709409 0,05277371 ! B cell lineage commitment GO:0002326 17 7 0,000 0,01709409 0,05270296 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,01709409 0,05263241 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,01709409 0,05256205 ! response to tropane GO:0014073 13 7 0,000 0,01709409 0,05249187 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,01709409 0,05242188 ! melanosome localization GO:0032400 10 7 0,000 0,01709409 0,05235208 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,01709409 0,05228246 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,01709409 0,05221303 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,01709409 0,05214378 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,01709409 0,05207472 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,01709409 0,05200583 ! mast cell activation GO:0045576 9 7 0,000 0,01709409 0,05193713 ! multicellular organismal aging GO:0010259 11 7 0,000 0,01709409 0,05186862 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,01709409 0,05180028 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,01709409 0,05173212 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,01709409 0,05166414 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,01709409 0,05159634 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,01709409 0,05152872 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,01709409 0,05146127 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,01709409 0,051394 ! T cell lineage commitment GO:0002360 12 7 0,000 0,01709409 0,05132691 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,01709409 0,05125999 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,01709409 0,05119324 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,01709409 0,05112667 ! regulation of lipid transport GO:0032368 13 7 0,000 0,01709409 0,05106027 ! response to tumor cell GO:0002347 12 7 0,000 0,01709409 0,05099405 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,01709409 0,05092799 ! neuroblast proliferation GO:0007405 13 7 0,000 0,01709409 0,05086211 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,01709409 0,0507964 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,01709409 0,05073085 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,01709409 0,05066548 ! diuresis GO:0030146 12 7 0,000 0,01709409 0,05060027 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,01709409 0,05053523 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,01709409 0,05047036 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,01709409 0,05040565 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,01709409 0,05034111 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,01709409 0,05027674 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,01709409 0,05021253 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,01709409 0,05014848 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,01709409 0,0500846 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,01709409 0,05002088 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,01709409 0,04995732 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,01709409 0,04989392 ! lymph node development GO:0048535 9 7 0,000 0,01709409 0,04983068 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,01709409 0,04976761 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,01709409 0,04970469 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,01709409 0,04964193 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,01709409 0,04957933 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,01709409 0,04951689 ! ATP catabolic process GO:0006200 10 7 0,000 0,01709409 0,0494546 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,01709409 0,04939248 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,01709409 0,0493305 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,01709409 0,04926868 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,01709409 0,04920702 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,01709409 0,04914551 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,01709409 0,04908416 ! muscle adaptation GO:0043500 12 7 0,000 0,01709409 0,04902296 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,01709409 0,04896191 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,01709409 0,04890101 ! retina homeostasis GO:0001895 9 7 0,000 0,01709409 0,04884026 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,01709409 0,04877967 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,01709409 0,04871922 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,01709409 0,04865892 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,01709409 0,04859878 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,01709409 0,04853878 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,01709409 0,04847893 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,01709409 0,04841922 ! ossification GO:0001503 134 82 1,000 0,01732976 0,04902638 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,01773024 0,05009772 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,01773024 0,05003625 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,01854295 0,05226568 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,01854295 0,0522017 ! regulation of protein localization GO:0032880 132 85 1,000 0,01854295 0,05213789 ! regulation of membrane potential GO:0042391 128 85 1,000 0,01854295 0,05207423 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,01854295 0,05201072 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,01895515 0,05310213 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,01895515 0,05303753 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,01951269 0,0545312 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,01951269 0,05446502 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,01951269 0,05439901 ! axon extension GO:0048675 11 8 0,000 0,01951269 0,05433315 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,01951269 0,05426745 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,01951269 0,05420191 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,01951269 0,05413653 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,01951269 0,0540713 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,01951269 0,05400623 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,01951269 0,05394132 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,01951269 0,05387657 ! phosphate transport GO:0006817 10 8 0,000 0,01951269 0,05381197 ! N-glycan processing GO:0006491 12 8 0,000 0,01951269 0,05374752 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,01951269 0,05368323 ! UTP metabolic process GO:0046051 8 8 0,000 0,01951269 0,05361909 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,01951269 0,05355511 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,01951269 0,05349127 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,01951269 0,05342759 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,01951269 0,05336407 ! succinate metabolic process GO:0006105 14 8 0,000 0,01951269 0,05330069 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,01951269 0,05323746 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,01951269 0,05317438 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,01951269 0,05311146 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,01951269 0,05304868 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,01951269 0,05298604 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,01951269 0,05292356 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,01951269 0,05286122 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,01951269 0,05279903 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,01951269 0,05273699 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,01951269 0,05267509 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,01951269 0,05261334 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,01951269 0,05255173 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,01951269 0,05249027 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,01951269 0,05242895 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,01951269 0,05236777 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,01951269 0,05230674 ! astrocyte differentiation GO:0048708 16 8 0,000 0,01951269 0,05224584 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,01951269 0,05218509 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,01951269 0,05212448 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,01951269 0,05206401 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,01951269 0,05200368 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,01951269 0,05194349 ! melanin metabolic process GO:0006582 12 8 0,000 0,01951269 0,05188344 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,01951269 0,05182353 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,01951269 0,05176376 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,01951269 0,05170412 ! macrophage activation GO:0042116 12 8 0,000 0,01951269 0,05164463 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,01951269 0,05158526 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,01951269 0,05152604 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,01951269 0,05146695 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,01951269 0,051408 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,01951269 0,05134918 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,01951269 0,05129049 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,01951269 0,05123194 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,01951269 0,05117352 ! ruffle organization GO:0031529 11 8 0,000 0,01951269 0,05111524 ! osteoblast development GO:0002076 13 8 0,000 0,01951269 0,05105709 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,01951269 0,05099907 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,01951269 0,05094118 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,01951269 0,05088342 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,01951269 0,0508258 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,01951269 0,0507683 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,01951269 0,05071094 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,01951269 0,0506537 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,01951269 0,05059659 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,01951269 0,05053962 ! brain morphogenesis GO:0048854 20 8 0,000 0,01951269 0,05048277 ! oligodendrocyte development GO:0014003 8 8 0,000 0,01951269 0,05042604 ! segment specification GO:0007379 10 8 0,000 0,01951269 0,05036945 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,01951269 0,05031298 ! cellular extravasation GO:0045123 11 8 0,000 0,01951269 0,05025664 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,01951269 0,05020042 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,01951269 0,05014433 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,01951269 0,05008837 ! snRNA metabolic process GO:0016073 10 8 0,000 0,01951269 0,05003253 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,01951269 0,04997681 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,01951269 0,04992122 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,01951269 0,04986576 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,01951269 0,04981041 ! nucleosome disassembly GO:0006337 12 8 0,000 0,01951269 0,04975519 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,01951269 0,04970009 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,01951269 0,04964511 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,01951269 0,04959025 ! icosanoid secretion GO:0032309 12 8 0,000 0,01951269 0,04953552 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,01951269 0,0494809 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,01951269 0,04942641 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,01951269 0,04937203 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,01951269 0,04931778 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,01951269 0,04926364 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,01951269 0,04920963 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,01951269 0,04915573 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,01951269 0,04910195 ! sterol catabolic process GO:0016127 9 8 0,000 0,01951269 0,04904828 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,01951269 0,04899474 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,01951269 0,04894131 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,01951269 0,048888 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,01951269 0,0488348 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,01951269 0,04878172 ! prophase GO:0051324 11 8 0,000 0,01951269 0,04872875 ! S phase GO:0051320 8 8 0,000 0,01951269 0,0486759 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,01951269 0,04862316 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,01951269 0,04857054 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,01951269 0,04851803 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,01951269 0,04846564 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,01951269 0,04841335 ! hormone catabolic process GO:0042447 13 8 0,000 0,01951269 0,04836118 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,01951269 0,04830913 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,01951269 0,04825718 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,01951269 0,04820535 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,01951269 0,04815363 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,01951269 0,04810201 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,01951269 0,04805051 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,01951269 0,04799912 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,01951269 0,04794784 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,01951269 0,04789667 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,01951269 0,04784561 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,01951269 0,04779465 ! lamellipodium assembly GO:0030032 9 8 0,000 0,01951269 0,04774381 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,01951269 0,04769307 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,01951269 0,04764244 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,01951269 0,04759192 ! interphase GO:0051325 159 88 1,000 0,01979113 0,04821992 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,02021487 0,04920021 ! reproductive developmental process GO:0003006 127 89 1,000 0,02021487 0,0491482 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,02021487 0,0490963 ! regulation of T cell activation GO:0050863 128 89 1,000 0,02021487 0,04904451 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,02150883 0,05212888 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,02150883 0,05207401 ! cell fate commitment GO:0045165 141 92 1,000 0,02150883 0,05201925 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02192547 0,0529712 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02192547 0,05291561 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,02192547 0,05286015 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02192547 0,05280479 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02192547 0,05274956 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02192547 0,05269444 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02192547 0,05263943 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02192547 0,05258454 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02192547 0,05252977 ! GTP metabolic process GO:0046039 9 9 0,000 0,02192547 0,05247511 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02192547 0,05242056 ! social behavior GO:0035176 14 9 0,000 0,02192547 0,05236613 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02192547 0,0523118 ! artery development GO:0060840 19 9 0,000 0,02192547 0,05225759 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02192547 0,0522035 ! response to pain GO:0048265 16 9 0,000 0,02192547 0,05214951 ! protein complex disassembly GO:0043241 17 9 0,000 0,02192547 0,05209564 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02192547 0,05204188 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02192547 0,05198823 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02192547 0,05193468 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02192547 0,05188125 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02192547 0,05182793 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02192547 0,05177472 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02192547 0,05172162 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02192547 0,05166863 ! protein targeting to ER GO:0045047 19 9 0,000 0,02192547 0,05161574 ! T cell selection GO:0045058 18 9 0,000 0,02192547 0,05156296 ! endoderm development GO:0007492 12 9 0,000 0,02192547 0,05151029 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02192547 0,05145773 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02192547 0,05140528 ! arginine catabolic process GO:0006527 10 9 0,000 0,02192547 0,05135293 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02192547 0,05130069 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02192547 0,05124856 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02192547 0,05119653 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02192547 0,0511446 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02192547 0,05109278 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02192547 0,05104107 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02192547 0,05098946 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02192547 0,05093796 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02192547 0,05088656 ! mannose metabolic process GO:0006013 9 9 0,000 0,02192547 0,05083526 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02192547 0,05078407 ! epithelial cell development GO:0002064 10 9 0,000 0,02192547 0,05073298 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02192547 0,05068199 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02192547 0,0506311 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02192547 0,05058032 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02192547 0,05052964 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02192547 0,05047906 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02192547 0,05042858 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02192547 0,0503782 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02192547 0,05032792 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02192547 0,05027775 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02192547 0,05022767 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02192547 0,05017769 ! DNA ligation GO:0006266 14 9 0,000 0,02192547 0,05012781 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02192547 0,05007803 ! response to amine stimulus GO:0014075 13 9 0,000 0,02192547 0,05002835 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02192547 0,04997877 ! erythrocyte development GO:0048821 11 9 0,000 0,02192547 0,04992929 ! renal water homeostasis GO:0003091 14 9 0,000 0,02192547 0,0498799 ! postreplication repair GO:0006301 11 9 0,000 0,02192547 0,04983061 ! mRNA cleavage GO:0006379 13 9 0,000 0,02192547 0,04978142 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02192547 0,04973233 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02192547 0,04968333 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02192547 0,04963443 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02192547 0,04958562 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02192547 0,04953691 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02192547 0,0494883 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02192547 0,04943978 ! acid secretion GO:0046717 14 9 0,000 0,02192547 0,04939136 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02192547 0,04934303 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02192547 0,0492948 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02192547 0,04924666 ! purine base metabolic process GO:0006144 18 9 0,000 0,02192547 0,04919861 ! oocyte differentiation GO:0009994 12 9 0,000 0,02192547 0,04915066 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02192547 0,0491028 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02192547 0,04905504 ! spleen development GO:0048536 15 9 0,000 0,02192547 0,04900736 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02192547 0,04895978 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02192547 0,0489123 ! detection of calcium ion GO:0005513 13 9 0,000 0,02192547 0,0488649 ! blastocyst formation GO:0001825 12 9 0,000 0,02192547 0,0488176 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02192547 0,04877039 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02192547 0,04872326 ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02192547 0,04867623 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02192547 0,04862929 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02192547 0,04858245 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02192547 0,04853569 ! prepulse inhibition GO:0060134 14 9 0,000 0,02192547 0,04848902 ! embryonic placenta development GO:0001892 12 9 0,000 0,02192547 0,04844244 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,02192547 0,04839595 ! insulin secretion GO:0030073 17 9 0,000 0,02192547 0,04834955 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02192547 0,04830324 ! response to nicotine GO:0035094 16 9 0,000 0,02192547 0,04825701 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02192547 0,04821088 ! nucleus localization GO:0051647 15 9 0,000 0,02192547 0,04816483 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02192547 0,04811887 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,02194766 0,04812167 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,02194766 0,04807584 ! response to light stimulus GO:0009416 153 96 1,000 0,02328643 0,05095985 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02433245 0,05319833 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02433245 0,0531478 ! neuron fate specification GO:0048665 11 10 0,000 0,02433245 0,05309738 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02433245 0,05304705 ! thyroid gland development GO:0030878 19 10 0,000 0,02433245 0,05299682 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,02433245 0,05294668 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02433245 0,05289663 ! synapsis GO:0007129 13 10 0,000 0,02433245 0,05284668 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02433245 0,05279683 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02433245 0,05274707 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02433245 0,0526974 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02433245 0,05264783 ! sulfate transport GO:0008272 12 10 0,000 0,02433245 0,05259834 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02433245 0,05254896 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,02433245 0,05249966 ! androgen metabolic process GO:0008209 13 10 0,000 0,02433245 0,05245046 ! phospholipid efflux GO:0033700 16 10 0,000 0,02433245 0,05240135 ! hippocampus development GO:0021766 19 10 0,000 0,02433245 0,05235233 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02433245 0,0523034 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02433245 0,05225456 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02433245 0,05220582 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02433245 0,05215717 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02433245 0,0521086 ! pathogenesis GO:0009405 13 10 0,000 0,02433245 0,05206013 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02433245 0,05201175 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02433245 0,05196345 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02433245 0,05191525 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,02433245 0,05186713 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02433245 0,05181911 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02433245 0,05177117 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02433245 0,05172333 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02433245 0,05167557 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,02433245 0,05162789 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02433245 0,05158031 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02433245 0,05153282 ! response to X-ray GO:0010165 16 10 0,000 0,02433245 0,05148541 ! B cell proliferation GO:0042100 14 10 0,000 0,02433245 0,05143809 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02433245 0,05139085 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02433245 0,0513437 ! forebrain cell migration GO:0021885 17 10 0,000 0,02433245 0,05129664 ! lipid digestion GO:0044241 15 10 0,000 0,02433245 0,05124967 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02433245 0,05120278 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02433245 0,05115598 ! UV protection GO:0009650 14 10 0,000 0,02433245 0,05110926 ! entry into host cell GO:0030260 20 10 0,000 0,02433245 0,05106263 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02433245 0,05101608 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02433245 0,05096962 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02433245 0,05092324 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02433245 0,05087694 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,02433245 0,05083073 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02433245 0,05078461 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02433245 0,05073857 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02433245 0,05069261 ! regulation of organ growth GO:0046620 11 10 0,000 0,02433245 0,05064673 ! response to dsRNA GO:0043331 18 10 0,000 0,02433245 0,05060094 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02433245 0,05055523 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02433245 0,0505096 ! embryonic axis specification GO:0000578 12 10 0,000 0,02433245 0,05046406 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02433245 0,05041859 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02433245 0,05037321 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02433245 0,05032791 ! cranial nerve development GO:0021545 12 10 0,000 0,02433245 0,05028269 ! fucose catabolic process GO:0019317 16 10 0,000 0,02433245 0,05023756 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02433245 0,0501925 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02433245 0,05014753 ! protein sumoylation GO:0016925 12 10 0,000 0,02433245 0,05010263 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02433245 0,05005782 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02433245 0,05001308 ! zymogen activation GO:0031638 14 10 0,000 0,02433245 0,04996843 ! salivary gland development GO:0007431 22 10 0,000 0,02433245 0,04992385 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02433245 0,04987936 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02433245 0,04983494 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02433245 0,0497906 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02433245 0,04974635 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02433245 0,04970217 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02433245 0,04965806 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02433245 0,04961404 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02433245 0,0495701 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02433245 0,04952623 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02433245 0,04948244 ! detection of bacterium GO:0016045 10 10 0,000 0,02433245 0,04943873 ! embryonic gut development GO:0048566 11 10 0,000 0,02433245 0,04939509 ! activation of innate immune response GO:0002218 10 10 0,000 0,02433245 0,04935153 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02433245 0,04930805 ! developmental induction GO:0031128 13 10 0,000 0,02433245 0,04926465 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02433245 0,04922132 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02433245 0,04917807 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02433245 0,04913489 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,02465818 0,04974896 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,02512267 0,05064166 ! rRNA transcription GO:0009303 17 11 0,000 0,02673365 0,05384185 ! respiratory burst GO:0045730 14 11 0,000 0,02673365 0,05379474 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,02673365 0,05374772 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,02673365 0,05370078 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,02673365 0,05365392 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,02673365 0,05360714 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,02673365 0,05356044 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,02673365 0,05351383 ! RNA polyadenylation GO:0043631 19 11 0,000 0,02673365 0,0534673 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,02673365 0,05342084 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,02673365 0,05337447 ! mating GO:0007618 14 11 0,000 0,02673365 0,05332818 ! T cell proliferation GO:0042098 20 11 0,000 0,02673365 0,05328197 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,02673365 0,05323584 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,02673365 0,05318978 ! bone resorption GO:0045453 16 11 0,000 0,02673365 0,05314381 ! regulated secretory pathway GO:0045055 14 11 0,000 0,02673365 0,05309792 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,02673365 0,05305211 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,02673365 0,05300637 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,02673365 0,05296071 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,02673365 0,05291514 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,02673365 0,05286964 ! syncytium formation GO:0006949 15 11 0,000 0,02673365 0,05282422 ! plasma membrane organization GO:0007009 18 11 0,000 0,02673365 0,05277888 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,02673365 0,05273361 ! focal adhesion formation GO:0048041 24 11 0,000 0,02673365 0,05268842 ! mitotic spindle organization GO:0007052 15 11 0,000 0,02673365 0,05264331 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,02673365 0,05259828 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,02673365 0,05255332 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,02673365 0,05250845 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,02673365 0,05246364 ! adult heart development GO:0007512 11 11 0,000 0,02673365 0,05241892 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,02673365 0,05237427 ! temperature homeostasis GO:0001659 16 11 0,000 0,02673365 0,05232969 ! L-glutamate transport GO:0015813 16 11 0,000 0,02673365 0,0522852 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,02673365 0,05224077 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,02673365 0,05219643 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,02673365 0,05215215 ! stem cell development GO:0048864 29 11 0,000 0,02673365 0,05210796 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,02673365 0,05206384 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,02673365 0,05201979 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,02673365 0,05197582 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,02673365 0,05193192 ! vasoconstriction GO:0042310 15 11 0,000 0,02673365 0,05188809 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,02673365 0,05184434 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,02673365 0,05180067 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,02673365 0,05175706 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,02673365 0,05171353 ! ribosome assembly GO:0042255 13 11 0,000 0,02673365 0,05167008 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,02673365 0,05162669 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,02673365 0,05158338 ! chromatin silencing GO:0006342 19 11 0,000 0,02673365 0,05154014 ! nucleosome positioning GO:0016584 13 11 0,000 0,02673365 0,05149698 ! T cell homeostasis GO:0043029 20 11 0,000 0,02673365 0,05145388 ! regulation of isotype switching GO:0045191 19 11 0,000 0,02673365 0,05141086 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,02673365 0,05136791 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,02673365 0,05132503 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,02673365 0,05128223 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,02673365 0,05123949 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,02673365 0,05119683 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,02673365 0,05115423 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,02673365 0,05111171 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,02673365 0,05106926 ! male genitalia development GO:0030539 13 11 0,000 0,02673365 0,05102688 ! cholesterol efflux GO:0033344 19 11 0,000 0,02673365 0,05098457 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,02673365 0,05094233 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,02673365 0,05090016 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,02673365 0,05085806 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,02673365 0,05081602 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,02673365 0,05077406 ! defense response to fungus GO:0050832 12 11 0,000 0,02673365 0,05073217 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,02673365 0,05069035 ! lysogeny GO:0030069 18 11 0,000 0,02673365 0,05064859 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,02673365 0,05060691 ! acrosome reaction GO:0007340 13 11 0,000 0,02673365 0,05056529 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,02673365 0,05052374 ! lactation GO:0007595 20 12 0,000 0,02912907 0,05500564 ! reproductive cellular process GO:0048610 14 12 0,000 0,02912907 0,05496051 ! tRNA modification GO:0006400 14 12 0,000 0,02912907 0,05491546 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,02912907 0,05487049 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,02912907 0,05482559 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,02912907 0,05478076 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,02912907 0,054736 ! non-recombinational repair GO:0000726 19 12 0,000 0,02912907 0,05469132 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,02912907 0,05464671 ! peroxisomal transport GO:0043574 21 12 0,000 0,02912907 0,05460217 ! cartilage condensation GO:0001502 18 12 0,000 0,02912907 0,05455771 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,02912907 0,05451332 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,02912907 0,054469 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,02912907 0,05442475 ! heart looping GO:0001947 15 12 0,000 0,02912907 0,05438057 ! palate development GO:0060021 15 12 0,000 0,02912907 0,05433647 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,02912907 0,05429244 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,02912907 0,05424847 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,02912907 0,05420458 ! arginine metabolic process GO:0006525 13 12 0,000 0,02912907 0,05416076 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,02912907 0,05411702 ! methionine metabolic process GO:0006555 13 12 0,000 0,02912907 0,05407334 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,02912907 0,05402973 ! Golgi organization GO:0007030 18 12 0,000 0,02912907 0,05398619 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,02912907 0,05394273 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,02912907 0,05389933 ! monoamine transport GO:0015844 13 12 0,000 0,02912907 0,053856 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,02912907 0,05381274 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,02912907 0,05376955 ! L-amino acid transport GO:0015807 20 12 0,000 0,02912907 0,05372644 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,02912907 0,05368339 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,02912907 0,0536404 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,02912907 0,05359749 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,02912907 0,05355465 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,02912907 0,05351187 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,02912907 0,05346917 ! cerebellum development GO:0021549 13 12 0,000 0,02912907 0,05342653 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,02912907 0,05338396 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,02912907 0,05334145 ! histone acetylation GO:0016573 23 12 0,000 0,02912907 0,05329902 ! histone methylation GO:0016571 15 12 0,000 0,02912907 0,05325665 ! autonomic nervous system development GO:0048483 23 12 0,000 0,02912907 0,05321435 ! gland morphogenesis GO:0022612 23 12 0,000 0,02912907 0,05317212 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,02912907 0,05312995 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,02912907 0,05308785 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,02912907 0,05304582 ! response to gamma radiation GO:0010332 20 12 0,000 0,02912907 0,05300385 ! regulation of epidermis development GO:0045682 17 12 0,000 0,02912907 0,05296195 ! intestinal absorption GO:0050892 19 12 0,000 0,02912907 0,05292011 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,02912907 0,05287835 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,02912907 0,05283664 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,02912907 0,05279501 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,02912907 0,05275344 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,02912907 0,05271193 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,02912907 0,05267049 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,02912907 0,05262912 ! microspike assembly GO:0030035 23 12 0,000 0,02912907 0,05258781 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,02912907 0,05254656 ! response to cold GO:0009409 14 12 0,000 0,02912907 0,05250538 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,03151874 0,05676828 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,03151874 0,05672386 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03151874 0,05667951 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03151874 0,05663523 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03151874 0,05659102 ! water transport GO:0006833 17 13 0,000 0,03151874 0,05654688 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,03151874 0,0565028 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03151874 0,0564588 ! lipid localization GO:0010876 24 13 0,000 0,03151874 0,05641486 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03151874 0,05637099 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03151874 0,05632719 ! organelle fusion GO:0048284 28 13 0,000 0,03151874 0,05628346 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03151874 0,05623979 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03151874 0,0561962 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,03151874 0,05615267 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03151874 0,05610921 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03151874 0,05606581 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03151874 0,05602248 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03151874 0,05597922 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03151874 0,05593603 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03151874 0,0558929 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03151874 0,05584984 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03151874 0,05580685 ! NAD metabolic process GO:0019674 21 13 0,000 0,03151874 0,05576392 ! exocrine system development GO:0035272 27 13 0,000 0,03151874 0,05572106 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03151874 0,05567826 ! bone mineralization GO:0030282 15 13 0,000 0,03151874 0,05563553 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03151874 0,05559286 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03151874 0,05555026 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03151874 0,05550773 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03151874 0,05546526 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03151874 0,05542286 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03151874 0,05538052 ! genitalia development GO:0048806 15 13 0,000 0,03151874 0,05533824 ! regulation of cellular pH GO:0030641 20 13 0,000 0,03151874 0,05529603 ! cellular pigmentation GO:0033059 24 13 0,000 0,03151874 0,05525388 ! tissue regeneration GO:0042246 21 13 0,000 0,03151874 0,0552118 ! cofactor transport GO:0051181 19 13 0,000 0,03151874 0,05516978 ! NADP metabolic process GO:0006739 18 13 0,000 0,03151874 0,05512783 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03151874 0,05508594 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03151874 0,05504411 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03151874 0,05500235 ! gas transport GO:0015669 18 13 0,000 0,03151874 0,05496065 ! regulation of RNA stability GO:0043487 28 13 0,000 0,03151874 0,05491901 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03151874 0,05487744 ! regulation of axon extension GO:0030516 23 13 0,000 0,03151874 0,05483593 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03151874 0,05479448 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03151874 0,05475309 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03151874 0,05471177 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03151874 0,05467051 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03151874 0,05462931 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03151874 0,05458817 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,03390266 0,05867277 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,03390266 0,05862865 ! superoxide anion generation GO:0042554 18 14 0,000 0,03390266 0,05858461 ! neuron maturation GO:0042551 21 14 0,000 0,03390266 0,05854062 ! regulation of S phase GO:0033261 18 14 0,000 0,03390266 0,05849671 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,03390266 0,05845286 ! myotube differentiation GO:0014902 21 14 0,000 0,03390266 0,05840907 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,03390266 0,05836535 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,03390266 0,0583217 ! inositol metabolic process GO:0006020 20 14 0,000 0,03390266 0,05827811 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,03390266 0,05823459 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,03390266 0,05819113 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,03390266 0,05814773 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,03390266 0,0581044 ! gene silencing by RNA GO:0031047 20 14 0,000 0,03390266 0,05806114 ! response to cAMP GO:0051591 19 14 0,000 0,03390266 0,05801794 ! limbic system development GO:0021761 25 14 0,000 0,03390266 0,0579748 ! startle response GO:0001964 21 14 0,000 0,03390266 0,05793173 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,03390266 0,05788872 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,03390266 0,05784578 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,03390266 0,0578029 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,03390266 0,05776008 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,03390266 0,05771733 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,03390266 0,05767464 ! glycine metabolic process GO:0006544 22 14 0,000 0,03390266 0,05763201 ! pituitary gland development GO:0021983 23 14 0,000 0,03390266 0,05758945 ! cellular response to starvation GO:0009267 21 14 0,000 0,03390266 0,05754695 ! lysosomal transport GO:0007041 20 14 0,000 0,03390266 0,05750451 ! regulation of heart rate GO:0002027 23 14 0,000 0,03390266 0,05746213 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,03390266 0,05741982 ! embryo implantation GO:0007566 27 14 0,000 0,03390266 0,05737756 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,03390266 0,05733538 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,03390266 0,05729325 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,03390266 0,05725118 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,03390266 0,05720918 ! axon cargo transport GO:0008088 27 14 0,000 0,03390266 0,05716724 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,03390266 0,05712536 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,03390266 0,05708354 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,03390266 0,05704178 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,03390266 0,05700008 ! mRNA splice site selection GO:0006376 26 14 0,000 0,03390266 0,05695844 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,03390266 0,05691687 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,03390266 0,05687535 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,03390266 0,0568339 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,03390266 0,05679251 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,03390266 0,05675117 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,03390266 0,0567099 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,03390266 0,05666868 ! muscle maintenance GO:0046716 19 14 0,000 0,03390266 0,05662753 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,03390266 0,05658644 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,03390266 0,0565454 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,03390266 0,05650443 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,03390266 0,05646351 ! cilium assembly GO:0042384 20 14 0,000 0,03390266 0,05642266 ! peptide hormone secretion GO:0030072 23 14 0,000 0,03390266 0,05638186 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,03628084 0,06029331 ! metencephalon development GO:0022037 19 15 0,000 0,03628084 0,06024978 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,03628084 0,06020631 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,03628084 0,0601629 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,03628084 0,06011956 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,03628084 0,06007627 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,03628084 0,06003305 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,03628084 0,05998989 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,03628084 0,0599468 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,03628084 0,05990376 ! bile acid metabolic process GO:0008206 22 15 0,000 0,03628084 0,05986079 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,03628084 0,05981788 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,03628084 0,05977503 ! adult walking behavior GO:0007628 25 15 0,000 0,03628084 0,05973224 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,03628084 0,05968952 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,03628084 0,05964685 ! myoblast differentiation GO:0045445 27 15 0,000 0,03628084 0,05960424 ! centrosome cycle GO:0007098 16 15 0,000 0,03628084 0,0595617 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,03628084 0,05951922 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,03628084 0,05947679 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,03628084 0,05943443 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,03628084 0,05939213 ! cerebral cortex development GO:0021987 29 15 0,000 0,03628084 0,05934989 ! response to osmotic stress GO:0006970 22 15 0,000 0,03628084 0,05930771 ! vesicle coating GO:0006901 25 15 0,000 0,03628084 0,05926558 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,03628084 0,05922352 ! DNA integration GO:0015074 22 15 0,000 0,03628084 0,05918152 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,03628084 0,05913958 ! peptide secretion GO:0002790 27 15 0,000 0,03628084 0,05909769 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,03628084 0,05905587 ! regulation of vasodilation GO:0042312 24 15 0,000 0,03628084 0,0590141 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,03628084 0,0589724 ! neuron recognition GO:0008038 22 15 0,000 0,03628084 0,05893075 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,03628084 0,05888916 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,03628084 0,05884763 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,03628084 0,05880616 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,03628084 0,05876475 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,03628084 0,05872339 ! biomineral formation GO:0031214 18 15 0,000 0,03628084 0,0586821 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,03628084 0,05864086 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,03628084 0,05859968 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,03628084 0,05855856 ! dopamine metabolic process GO:0042417 30 15 0,000 0,03628084 0,05851749 ! organic cation transport GO:0015695 19 15 0,000 0,03628084 0,05847648 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,03628084 0,05843553 GO:0033014|tetrapyrrole biosynthetic process, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,03628084 0,05839464 ! defense response to virus GO:0051607 27 15 0,000 0,03628084 0,05835381 ! peptide hormone processing GO:0016486 19 15 0,000 0,03628084 0,05831303 ! protein secretion GO:0009306 27 16 0,000 0,03865331 0,06208284 ! hormone secretion GO:0046879 25 16 0,000 0,03865331 0,06203951 ! bone remodeling GO:0046849 24 16 0,000 0,03865331 0,06199625 ! endothelial cell migration GO:0043542 22 16 0,000 0,03865331 0,06195305 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,03865331 0,0619099 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,03865331 0,06186682 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,03865331 0,0618238 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,03865331 0,06178084 ! glial cell development GO:0021782 24 16 0,000 0,03865331 0,06173793 ! patterning of blood vessels GO:0001569 24 16 0,000 0,03865331 0,06169509 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,03865331 0,0616523 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,03865331 0,06160958 ! protein polyubiquitination GO:0000209 26 16 0,000 0,03865331 0,06156691 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,03865331 0,06152431 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,03865331 0,06148176 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,03865331 0,06143927 ! fructose metabolic process GO:0006000 20 16 0,000 0,03865331 0,06139684 ! regulation of protein binding GO:0043393 27 16 0,000 0,03865331 0,06135447 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,03865331 0,06131215 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,03865331 0,0612699 ! protein export from nucleus GO:0006611 24 16 0,000 0,03865331 0,0612277 ! negative regulation of immune response GO:0050777 28 16 0,000 0,03865331 0,06118556 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,03865331 0,06114348 ! DNA replication initiation GO:0006270 25 16 0,000 0,03865331 0,06110146 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,03865331 0,06105949 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,03865331 0,06101759 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,03865331 0,06097574 ! diencephalon development GO:0021536 25 16 0,000 0,03865331 0,06093394 ! oogenesis GO:0048477 23 16 0,000 0,03865331 0,06089221 ! neural crest cell migration GO:0001755 24 16 0,000 0,03865331 0,06085053 ! G1 phase GO:0051318 27 16 0,000 0,03865331 0,06080891 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,03865331 0,06076734 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,03865331 0,06072583 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,03865331 0,06068438 ! steroid catabolic process GO:0006706 22 16 0,000 0,03865331 0,06064299 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,03865331 0,06060165 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,03865331 0,06056037 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,03865331 0,06051914 ! sperm-egg recognition GO:0035036 16 16 0,000 0,03865331 0,06047797 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,03865331 0,06043686 ! nerve development GO:0021675 18 16 0,000 0,03865331 0,0603958 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,03865331 0,0603548 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,03865331 0,06031386 ! negative regulation of translation GO:0017148 22 16 0,000 0,03865331 0,06027296 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04102008 0,06392018 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04102008 0,0638769 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04102008 0,06383368 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,04102008 0,06379052 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04102008 0,06374742 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04102008 0,06370438 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04102008 0,06366139 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04102008 0,06361846 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04102008 0,06357559 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04102008 0,06353278 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04102008 0,06349003 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04102008 0,06344733 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04102008 0,06340469 ! memory GO:0007613 25 17 0,000 0,04102008 0,06336211 ! keratinization GO:0031424 17 17 0,000 0,04102008 0,06331958 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04102008 0,06327712 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04102008 0,06323471 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04102008 0,06319235 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,04102008 0,06315005 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04102008 0,06310781 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,04102008 0,06306563 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,04102008 0,0630235 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,04102008 0,06298143 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,04102008 0,06293941 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,04102008 0,06289745 ! membrane budding GO:0006900 29 17 0,000 0,04102008 0,06285555 ! heme metabolic process GO:0042168 27 17 0,000 0,04102008 0,0628137 ! actin filament bundle formation GO:0051017 26 17 0,000 0,04102008 0,06277191 ! body fluid secretion GO:0007589 27 17 0,000 0,04102008 0,06273017 ! stem cell differentiation GO:0048863 36 17 0,000 0,04102008 0,06268849 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04102008 0,06264687 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,04102008 0,0626053 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04102008 0,06256378 ! sensory perception of pain GO:0019233 23 17 0,000 0,04102008 0,06252232 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04102008 0,06248091 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04102008 0,06243956 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,04102008 0,06239827 ! synaptogenesis GO:0007416 24 17 0,000 0,04102008 0,06235703 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,04102008 0,06231584 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04102008 0,06227471 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04102008 0,06223363 ! cell-cell junction organization GO:0045216 25 17 0,000 0,04102008 0,0621926 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04102008 0,06215163 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04102008 0,06211072 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,04102008 0,06206986 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04102008 0,06202905 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04102008 0,06198829 ! positive regulation of translation GO:0045727 28 18 0,000 0,04338115 0,06551323 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,04338115 0,06547024 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,04338115 0,06542731 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,04338115 0,06538444 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,04338115 0,06534162 ! cAMP metabolic process GO:0046058 33 18 0,000 0,04338115 0,06529885 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,04338115 0,06525615 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,04338115 0,0652135 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,04338115 0,0651709 ! axis specification GO:0009798 26 18 0,000 0,04338115 0,06512836 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,04338115 0,06508588 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,04338115 0,06504345 ! pancreas development GO:0031016 26 18 0,000 0,04338115 0,06500107 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,04338115 0,06495876 ! glutamine metabolic process GO:0006541 23 18 0,000 0,04338115 0,06491649 ! response to retinoic acid GO:0032526 25 18 0,000 0,04338115 0,06487428 ! pigmentation during development GO:0048066 31 18 0,000 0,04338115 0,06483213 ! central nervous system neuron development GO:0021954 30 18 0,000 0,04338115 0,06479003 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,04338115 0,06474799 ! fucose metabolic process GO:0006004 26 18 0,000 0,04338115 0,064706 ! response to fungus GO:0009620 19 18 0,000 0,04338115 0,06466406 ! peptide cross-linking GO:0018149 31 18 0,000 0,04338115 0,06462218 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,04338115 0,06458035 ! heart process GO:0003015 27 18 0,000 0,04338115 0,06453858 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,04338115 0,06449686 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,04338115 0,0644552 ! visual learning GO:0008542 35 18 0,000 0,04338115 0,06441359 ! somitogenesis GO:0001756 24 18 0,000 0,04338115 0,06437203 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,04338115 0,06433053 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,04338115 0,06428908 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,04338115 0,06424768 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,04338115 0,06420634 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,04338115 0,06416505 ! vitamin transport GO:0051180 24 18 0,000 0,04338115 0,06412381 ! hormone transport GO:0009914 27 18 0,000 0,04338115 0,06408263 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,04338115 0,06404149 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,04338115 0,06400042 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,04338115 0,06395939 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,04338115 0,06391842 ! cell-cell recognition GO:0009988 20 18 0,000 0,04338115 0,0638775 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,04338115 0,06383663 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,04338115 0,06379581 ! regulation of glucose import GO:0046324 21 18 0,000 0,04338115 0,06375505 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,04338115 0,06371433 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,04338115 0,06367367 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,04338115 0,06363307 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,04573655 0,06704529 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,04573655 0,06700258 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,04573655 0,06695993 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,04573655 0,06691734 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,04573655 0,0668748 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,04573655 0,06683231 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,04573655 0,06678988 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,04573655 0,0667475 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,04573655 0,06670517 ! regeneration GO:0031099 32 19 0,000 0,04573655 0,0666629 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,04573655 0,06662068 ! response to alkaloid GO:0043279 32 19 0,000 0,04573655 0,06657852 ! sensory perception of taste GO:0050909 23 19 0,000 0,04573655 0,0665364 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,04573655 0,06649435 ! smooth muscle contraction GO:0006939 36 19 0,000 0,04573655 0,06645234 ! peroxisome organization GO:0007031 29 19 0,000 0,04573655 0,06641039 ! digestive system process GO:0022600 30 19 0,000 0,04573655 0,06636849 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,04573655 0,06632664 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,04573655 0,06628485 ! response to vitamin A GO:0033189 26 19 0,000 0,04573655 0,06624311 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,04573655 0,06620142 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,04573655 0,06615978 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,04573655 0,0661182 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,04573655 0,06607667 ! response to starvation GO:0042594 30 19 0,000 0,04573655 0,06603519 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,04573655 0,06599376 ! plasma membrane fusion GO:0045026 23 19 0,000 0,04573655 0,06595239 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,04573655 0,06591106 ! cytolysis GO:0019835 20 19 0,000 0,04573655 0,06586979 ! renal system process GO:0003014 35 19 0,000 0,04573655 0,06582857 ! vasodilation GO:0042311 33 19 0,000 0,04573655 0,0657874 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,04573655 0,06574628 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,04573655 0,06570522 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,04573655 0,0656642 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,04573655 0,06562324 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,04573655 0,06558233 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,04573655 0,06554147 ! sarcomere organization GO:0045214 23 19 0,000 0,04573655 0,06550066 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,04573655 0,0654599 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,04573655 0,06541919 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,04573655 0,06537853 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,04573655 0,06533792 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,04573655 0,06529737 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,04573655 0,06525686 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,04573655 0,0652164 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,04808628 0,06852443 ! iron ion transport GO:0006826 37 20 0,000 0,04808628 0,068482 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,04808628 0,06843962 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,04808628 0,0683973 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,04808628 0,06835503 ! response to vitamin GO:0033273 29 20 0,000 0,04808628 0,06831281 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,04808628 0,06827064 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,04808628 0,06822852 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,04808628 0,06818646 ! spinal cord development GO:0021510 31 20 0,000 0,04808628 0,06814444 ! response to ethanol GO:0045471 37 20 0,000 0,04808628 0,06810248 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,04808628 0,06806057 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,04808628 0,06801872 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,04808628 0,06797691 ! chromosome condensation GO:0030261 31 20 0,000 0,04808628 0,06793516 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,04808628 0,06789345 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,04808628 0,0678518 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,04808628 0,0678102 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,04808628 0,06776865 ! pallium development GO:0021543 38 20 0,000 0,04808628 0,06772715 ! DNA modification GO:0006304 28 20 0,000 0,04808628 0,0676857 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,04808628 0,0676443 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,04808628 0,06760295 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,04808628 0,06756166 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,04808628 0,06752041 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,04808628 0,06747922 ! collagen catabolic process GO:0030574 25 20 0,000 0,04808628 0,06743807 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,04808628 0,06739697 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,04808628 0,06735593 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,04808628 0,06731493 ! alditol metabolic process GO:0019400 24 20 0,000 0,04808628 0,06727399 ! actin filament-based movement GO:0030048 34 20 0,000 0,04808628 0,06723309 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,05043035 0,07046769 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,05043035 0,0704249 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,05043035 0,07038217 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,05043035 0,07033949 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,05043035 0,07029686 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,05043035 0,07025428 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,05043035 0,07021175 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,05043035 0,07016928 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,05043035 0,07012685 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,05043035 0,07008448 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,05043035 0,07004216 ! protein amino acid acylation GO:0043543 37 21 0,000 0,05043035 0,06999989 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,05043035 0,06995767 ! vesicle docking GO:0048278 27 21 0,000 0,05043035 0,0699155 ! phototransduction GO:0007602 25 21 0,000 0,05043035 0,06987338 ! visual behavior GO:0007632 39 21 0,000 0,05043035 0,06983131 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,05043035 0,0697893 ! ovarian follicle development GO:0001541 30 21 0,000 0,05043035 0,06974733 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,05043035 0,06970542 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,05043035 0,06966355 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,05043035 0,06962174 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,05043035 0,06957997 ! cell aging GO:0007569 32 21 0,000 0,05043035 0,06953826 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,05043035 0,06949659 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,05043035 0,06945498 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,05043035 0,06941341 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,05043035 0,0693719 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,05043035 0,06933043 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,05043035 0,06928902 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,05043035 0,06924765 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,05043035 0,06920633 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,05043035 0,06916506 ! fatty acid transport GO:0015908 30 21 0,000 0,05043035 0,06912385 ! immunoglobulin production GO:0002377 33 21 0,000 0,05043035 0,06908268 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,05043035 0,06904156 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,05043035 0,06900048 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,05043035 0,06895946 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,05043035 0,06891849 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,05043035 0,06887756 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,05043035 0,06883668 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,05043035 0,06879586 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,05043035 0,06875508 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,05043035 0,06871434 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,05043035 0,06867366 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,05043035 0,06863303 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,05043035 0,06859244 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,05043035 0,0685519 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,05043035 0,06851141 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,05276879 0,07164594 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,05276879 0,07160367 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,05276879 0,07156145 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,05276879 0,07151928 ! viral genome replication GO:0019079 29 22 0,000 0,05276879 0,07147716 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,05276879 0,07143509 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,05276879 0,07139307 ! leukocyte adhesion GO:0007159 38 22 0,000 0,05276879 0,0713511 ! molting cycle process GO:0022404 40 22 0,000 0,05276879 0,07130918 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,05276879 0,07126731 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,05276879 0,07122548 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,05276879 0,07118371 ! vasculogenesis GO:0001570 33 22 0,000 0,05276879 0,07114198 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,05276879 0,07110031 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,05276879 0,07105868 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,05276879 0,0710171 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,05276879 0,07097557 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,05276879 0,07093409 ! lysosome organization GO:0007040 37 22 0,000 0,05276879 0,07089265 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,05276879 0,07085127 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,05276879 0,07080993 ! regulation of behavior GO:0050795 38 22 0,000 0,05276879 0,07076864 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,05276879 0,0707274 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,05276879 0,07068621 ! membrane depolarization GO:0051899 35 22 0,000 0,05276879 0,07064507 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,05276879 0,07060397 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,05276879 0,07056292 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,05276879 0,07052192 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,05276879 0,07048097 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,05276879 0,07044006 ! blastocyst development GO:0001824 37 22 0,000 0,05276879 0,0703992 ! neural tube closure GO:0001843 33 22 0,000 0,05276879 0,07035839 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,05510161 0,07342624 ! neuron fate commitment GO:0048663 32 23 0,000 0,05510161 0,07338373 ! embryonic pattern specification GO:0009880 31 23 0,000 0,05510161 0,07334126 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,05510161 0,07329884 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,05510161 0,07325647 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,05510161 0,07321415 ! vesicle targeting GO:0006903 32 23 0,000 0,05510161 0,07317188 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,05510161 0,07312966 ! osteoblast differentiation GO:0001649 40 23 0,000 0,05510161 0,07308748 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,05510161 0,07304536 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,05510161 0,07300328 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,05510161 0,07296125 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,05510161 0,07291927 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,05510161 0,07287734 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,05510161 0,07283546 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,05510161 0,07279362 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,05510161 0,07275184 ! cell fate determination GO:0001709 45 23 0,000 0,05510161 0,0727101 ! pentose metabolic process GO:0019321 31 23 0,000 0,05510161 0,0726684 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,05510161 0,07262676 ! spermatid development GO:0007286 33 23 0,000 0,05510161 0,07258516 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,05510161 0,07254362 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,05510161 0,07250212 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,05510161 0,07246066 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,05510161 0,07241926 ! telomere organization GO:0032200 32 23 0,000 0,05510161 0,0723779 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,05510161 0,07233659 ! regulation of amine transport GO:0051952 38 23 0,000 0,05510161 0,07229532 ! liver development GO:0001889 40 23 0,000 0,05510161 0,0722541 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,05742881 0,07526283 ! initiation of viral infection GO:0019059 42 24 0,000 0,05742881 0,07521997 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,05742881 0,07517716 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,05742881 0,07513439 ! superoxide metabolic process GO:0006801 32 24 0,000 0,05742881 0,07509168 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,05742881 0,07504901 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,05742881 0,0750064 ! fat cell differentiation GO:0045444 37 24 0,000 0,05742881 0,07496383 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,05742881 0,07492131 ! sperm motility GO:0030317 27 24 0,000 0,05742881 0,07487883 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,05742881 0,07483641 ! vacuole organization GO:0007033 39 24 0,000 0,05742881 0,07479403 ! neural crest cell development GO:0014032 39 24 0,000 0,05742881 0,07475171 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,05742881 0,07470943 ! primary neural tube formation GO:0014020 35 24 0,000 0,05742881 0,07466719 ! negative regulation of cell development GO:0010721 56 24 0,000 0,05742881 0,07462501 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,05742881 0,07458287 ! base-excision repair GO:0006284 31 24 0,000 0,05742881 0,07454078 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,05742881 0,07449874 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,05742881 0,07445674 ! glutathione metabolic process GO:0006749 29 24 0,000 0,05742881 0,0744148 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,05742881 0,0743729 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,05975041 0,07733593 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,05975041 0,07729244 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,05975041 0,07724899 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,05975041 0,07720559 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,05975041 0,07716224 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,05975041 0,07711894 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,05975041 0,07707569 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,05975041 0,07703248 ! peptide transport GO:0015833 43 25 0,000 0,05975041 0,07698933 ! male gonad development GO:0008584 33 25 0,000 0,05975041 0,07694622 ! iron ion homeostasis GO:0055072 39 25 0,000 0,05975041 0,07690316 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,05975041 0,07686015 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,05975041 0,07681719 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,05975041 0,07677428 ! phospholipid transport GO:0015914 35 25 0,000 0,05975041 0,07673141 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,05975041 0,07668859 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,05975041 0,07664582 ! detection of light stimulus GO:0009583 30 25 0,000 0,05975041 0,0766031 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,05975041 0,07656042 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,05975041 0,07651779 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,06206643 0,07943951 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,06206643 0,07939533 ! translational initiation GO:0006413 43 26 0,000 0,06206643 0,07935119 ! regulation of pH GO:0006885 36 26 0,000 0,06206643 0,07930711 ! circadian rhythm GO:0007623 42 26 0,000 0,06206643 0,07926307 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,06206643 0,07921909 ! post-embryonic development GO:0009791 42 26 0,000 0,06206643 0,07917515 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,06206643 0,07913126 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,06206643 0,07908742 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,06206643 0,07904363 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,06206643 0,07899989 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,06206643 0,07895619 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,06206643 0,07891255 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,06206643 0,07886895 ! regulation of coagulation GO:0050818 39 26 0,000 0,06206643 0,0788254 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,06437688 0,08171458 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,06437688 0,08166951 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,06437688 0,08162449 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,06437688 0,08157952 ! membrane docking GO:0022406 39 27 0,000 0,06437688 0,08153459 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,06437688 0,08148972 ! catechol metabolic process GO:0009712 43 27 0,000 0,06437688 0,0814449 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,06437688 0,08140012 ! acute-phase response GO:0006953 42 27 0,000 0,06437688 0,0813554 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,06437688 0,08131072 ! myofibril assembly GO:0030239 36 27 0,000 0,06437688 0,08126609 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,06437688 0,08122151 ! response to ionizing radiation GO:0010212 47 27 0,000 0,06437688 0,08117698 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,06437688 0,0811325 ! natural killer cell activation GO:0030101 35 27 0,000 0,06437688 0,08108807 ! lipid oxidation GO:0034440 38 27 0,000 0,06437688 0,08104369 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,06437688 0,08099935 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,06437688 0,08095507 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,06437688 0,08091083 ! gene silencing GO:0016458 41 27 0,000 0,06437688 0,08086664 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,06668177 0,08371619 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,06668177 0,08367052 ! phenol metabolic process GO:0018958 44 28 0,000 0,06668177 0,0836249 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,06668177 0,08357932 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,06668177 0,0835338 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,06668177 0,08348833 ! cell junction assembly GO:0034329 56 28 0,000 0,06668177 0,08344291 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,06668177 0,08339753 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,06668177 0,08335221 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,06668177 0,08330693 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,06668177 0,0832617 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,06668177 0,08321653 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,06668177 0,0831714 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,06668177 0,08312632 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,06668177 0,08308129 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,06668177 0,08303631 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,06668177 0,08299137 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,06668177 0,08294649 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,06668177 0,08290165 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,06668177 0,08285687 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,06668177 0,08281213 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,06668177 0,08276744 ! neural tube formation GO:0001841 41 28 0,000 0,06668177 0,08272279 ! placenta development GO:0001890 37 28 0,000 0,06668177 0,0826782 ! regulation of B cell activation GO:0050864 42 28 0,000 0,06668177 0,08263365 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,06898111 0,08543702 ! regulation of innate immune response GO:0045088 38 29 0,000 0,06898111 0,08539103 ! ovulation cycle process GO:0022602 41 29 0,000 0,06898111 0,0853451 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,06898111 0,08529922 ! protein targeting to membrane GO:0006612 53 29 0,000 0,06898111 0,08525338 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,06898111 0,0852076 ! mismatch repair GO:0006298 34 29 0,000 0,06898111 0,08516186 ! muscle cell development GO:0055001 38 29 0,000 0,06898111 0,08511617 ! telencephalon development GO:0021537 52 29 0,000 0,06898111 0,08507053 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,06898111 0,08502494 ! eye morphogenesis GO:0048592 51 29 0,000 0,06898111 0,0849794 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,06898111 0,08493391 ! tissue homeostasis GO:0001894 42 29 0,000 0,06898111 0,08488847 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,07127491 0,08766433 ! collagen metabolic process GO:0032963 40 30 0,000 0,07127491 0,08761748 ! organic anion transport GO:0015711 51 30 0,000 0,07127491 0,08757067 ! cholesterol transport GO:0030301 46 30 0,000 0,07127491 0,08752392 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,07127491 0,08747721 ! spliceosome assembly GO:0000245 49 30 0,000 0,07127491 0,08743056 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,07127491 0,08738395 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,07127491 0,0873374 ! ceramide metabolic process GO:0006672 43 30 0,000 0,07127491 0,08729089 ! ovulation cycle GO:0042698 43 30 0,000 0,07127491 0,08724444 ! hindbrain development GO:0030902 45 30 0,000 0,07127491 0,08719803 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,07127491 0,08715167 ! adult locomotory behavior GO:0008344 47 30 0,000 0,07127491 0,08710537 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,07127491 0,08705911 ! response to heat GO:0009408 41 30 0,000 0,07127491 0,0870129 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,07127491 0,08696674 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,07127491 0,08692062 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,0735632 0,08966368 ! negative regulation of secretion GO:0051048 49 31 0,000 0,0735632 0,08961618 ! glial cell differentiation GO:0010001 55 31 0,000 0,0735632 0,08956874 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,0735632 0,08952135 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,0735632 0,08947401 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,0735632 0,08942672 ! segmentation GO:0035282 41 31 0,000 0,0735632 0,08937948 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,0735632 0,08933229 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,0735632 0,08928515 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,0735632 0,08923806 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,0735632 0,08919102 ! cell fate specification GO:0001708 37 31 0,000 0,0735632 0,08914402 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,0735632 0,08909708 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,0735632 0,08905019 ! RNA modification GO:0009451 40 31 0,000 0,0735632 0,08900334 ! regulation of muscle development GO:0048634 48 32 0,000 0,07584598 0,09171701 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,07584598 0,09166881 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,07584598 0,09162067 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,07584598 0,09157257 ! meiosis I GO:0007127 52 32 0,000 0,07584598 0,09152453 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,07584598 0,09147653 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,07584598 0,09142859 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,07584598 0,0913807 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,07584598 0,09133285 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,07584598 0,09128506 ! cytokine production GO:0001816 44 32 0,000 0,07584598 0,09123732 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,07584598 0,09118962 ! vesicle localization GO:0051648 47 32 0,000 0,07584598 0,09114198 ! RNA export from nucleus GO:0006405 44 33 0,000 0,07812326 0,09382951 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,07812326 0,09378054 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,07812326 0,09373161 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,07812326 0,09368275 ! sister chromatid segregation GO:0000819 46 33 0,000 0,07812326 0,09363393 ! ear morphogenesis GO:0042471 42 33 0,000 0,07812326 0,09358516 ! actomyosin structure organization GO:0031032 43 33 0,000 0,07812326 0,09353644 ! cell junction organization GO:0034330 63 33 0,000 0,07812326 0,09348778 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,07812326 0,09343916 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,07812326 0,0933906 ! nucleus organization GO:0006997 49 33 0,000 0,07812326 0,09334208 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,07812326 0,09329362 ! female gonad development GO:0008585 49 33 0,000 0,07812326 0,0932452 ! lipid homeostasis GO:0055088 55 33 0,000 0,07812326 0,09319684 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,07812326 0,09314853 ! regulation of proteolysis GO:0030162 50 33 0,000 0,07812326 0,09310026 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,07812326 0,09305205 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,07812326 0,09300388 ! cytokinesis GO:0000910 52 33 0,000 0,07812326 0,09295577 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,07812326 0,09290771 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,08039507 0,09556003 ! mRNA catabolic process GO:0006402 48 34 0,000 0,08039507 0,09551067 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,08039507 0,09546136 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,08039507 0,0954121 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,08039507 0,09536289 ! feeding behavior GO:0007631 45 34 0,000 0,08039507 0,09531374 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,08039507 0,09526463 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,08039507 0,09521558 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,08039507 0,09516657 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,08039507 0,09511762 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,08039507 0,09506872 ! neuron migration GO:0001764 46 34 0,000 0,08039507 0,09501986 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,08039507 0,09497106 ! female gamete generation GO:0007292 43 34 0,000 0,08039507 0,09492231 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,08039507 0,0948736 ! polyol metabolic process GO:0019751 44 34 0,000 0,08039507 0,09482495 ! aerobic respiration GO:0009060 47 34 0,000 0,08039507 0,09477635 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,08039507 0,09472779 ! embryonic organ development GO:0048568 45 34 0,000 0,08039507 0,09467929 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,08039507 0,09463084 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,0826614 0,09724871 ! Notch signaling pathway GO:0007219 56 35 0,000 0,0826614 0,09719899 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,0826614 0,09714932 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,0826614 0,09709971 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,0826614 0,09705014 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,0826614 0,09700062 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,0826614 0,09695116 ! glycogen metabolic process GO:0005977 48 35 0,000 0,0826614 0,09690175 ! pigment metabolic process GO:0042440 61 35 0,000 0,0826614 0,09685238 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,0826614 0,09680307 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,0826614 0,0967538 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,08492228 0,09934957 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,08492228 0,09929906 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,08492228 0,0992486 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,08492228 0,09919819 ! organic ether metabolic process GO:0018904 46 36 0,000 0,08492228 0,09914784 ! tissue remodeling GO:0048771 62 36 0,000 0,08492228 0,09909754 ! neural tube development GO:0021915 50 36 0,000 0,08492228 0,09904728 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,08492228 0,09899708 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,08492228 0,09894693 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,08492228 0,09889683 ! glucan metabolic process GO:0044042 49 36 0,000 0,08492228 0,09884678 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,08717772 0,10142071 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,08717772 0,10136944 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,08717772 0,10131822 ! learning GO:0007612 67 37 0,000 0,08717772 0,10126705 ! ion transmembrane transport GO:0034220 56 37 0,000 0,08717772 0,10121593 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,08717772 0,10116486 ! regulation of protein secretion GO:0050708 51 37 0,000 0,08717772 0,10111384 ! amino acid activation GO:0043038 52 37 0,000 0,08717772 0,10106288 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,08717772 0,10101196 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,08942772 0,10356685 ! gliogenesis GO:0042063 71 38 0,000 0,08942772 0,10351473 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,08942772 0,10346266 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,08942772 0,10341064 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,08942772 0,10335868 ! phagocytosis GO:0006909 60 38 0,000 0,08942772 0,10330676 ! pigmentation GO:0043473 74 38 0,000 0,08942772 0,1032549 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,09167231 0,10579344 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,09167231 0,10574038 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,09167231 0,10568738 ! male sex differentiation GO:0046661 53 39 0,000 0,09167231 0,10563443 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,09167231 0,10558153 ! chromatin remodeling GO:0006338 68 39 0,000 0,09167231 0,10552869 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,09167231 0,1054759 ! JNK cascade GO:0007254 54 39 0,000 0,09167231 0,10542316 ! developmental growth GO:0048589 62 39 0,000 0,09167231 0,10537047 ! cell growth GO:0016049 61 39 0,000 0,09167231 0,10531784 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,0939115 0,10783647 ! response to calcium ion GO:0051592 58 40 0,000 0,0939115 0,10778266 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,0939115 0,1077289 ! regulation of tube size GO:0035150 60 40 0,000 0,0939115 0,1076752 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,0939115 0,10762155 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,0939115 0,10756795 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,0939115 0,10751441 ! peptide metabolic process GO:0006518 56 40 0,000 0,0939115 0,10746092 ! inner ear development GO:0048839 57 40 0,000 0,0939115 0,10740748 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,0939115 0,1073541 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,0939115 0,10730077 ! double-strand break repair GO:0006302 67 40 0,000 0,0939115 0,10724749 ! B cell differentiation GO:0030183 62 40 0,000 0,0939115 0,10719426 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,0939115 0,10714109 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,0939115 0,10708797 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,09614529 0,10958085 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,09614529 0,10952658 ! glucose transport GO:0015758 52 41 0,000 0,09614529 0,10947236 ! striated muscle contraction GO:0006941 62 41 0,000 0,09614529 0,10941819 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,09614529 0,10936408 ! biopolymer methylation GO:0043414 62 41 0,000 0,09614529 0,10931002 ! mitochondrial transport GO:0006839 60 42 0,000 0,0983737 0,1117883 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,0983737 0,11173309 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,0983737 0,11167794 ! cellular component disassembly GO:0022411 64 42 0,000 0,0983737 0,11162285 ! hexose transport GO:0008645 54 42 0,000 0,0983737 0,11156781 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,0983737 0,11151282 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,0983737 0,11145789 ! excretion GO:0007588 63 42 0,000 0,0983737 0,11140301 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,0983737 0,11134819 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,0983737 0,11129342 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,0983737 0,1112387 ! regulation of cell shape GO:0008360 78 42 0,000 0,0983737 0,11118404 ! leukocyte migration GO:0050900 60 43 0,000 0,10059675 0,11364073 ! neuromuscular process GO:0050905 79 43 0,000 0,10059675 0,11358494 ! activation of caspase activity GO:0006919 65 43 0,000 0,10059675 0,11352921 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,10059675 0,11347353 ! tRNA processing GO:0008033 49 43 0,000 0,10059675 0,1134179 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,10059675 0,11336233 ! vesicle organization GO:0016050 79 43 0,000 0,10059675 0,11330682 ! methylation GO:0032259 64 43 0,000 0,10059675 0,11325136 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,10281444 0,1156914 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,10281444 0,11563482 ! glycolysis GO:0006096 53 44 0,000 0,10281444 0,11557831 ! regulation of ion transport GO:0043269 57 44 0,000 0,10281444 0,11552184 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,10281444 0,11546544 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,10281444 0,11540908 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,10281444 0,11535279 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,10281444 0,11529655 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,10281444 0,11524036 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,10281444 0,11518423 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,10281444 0,11512815 ! RNA catabolic process GO:0006401 64 45 0,000 0,10502679 0,11754823 ! positive regulation of defense response GO:0031349 59 45 0,000 0,10502679 0,11749106 ! regulation of translational initiation GO:0006446 64 45 0,000 0,10502679 0,11743394 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,10502679 0,11737688 ! cell recognition GO:0008037 58 45 0,000 0,10502679 0,11731987 ! cell maturation GO:0048469 60 45 0,000 0,10502679 0,11726292 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,10723381 0,11966898 ! cell redox homeostasis GO:0045454 63 46 0,000 0,10723381 0,11961095 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,10723381 0,11955297 ! histone modification GO:0016570 68 46 0,000 0,10723381 0,11949504 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,10723381 0,11943718 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,10943552 0,12183044 ! viral infectious cycle GO:0019058 71 47 0,000 0,10943552 0,1217715 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,10943552 0,12171262 ! endocrine system development GO:0035270 83 47 0,000 0,10943552 0,12165379 ! covalent chromatin modification GO:0016569 75 47 0,000 0,10943552 0,12159502 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,10943552 0,12153631 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,10943552 0,12147765 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,10943552 0,12141905 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,10943552 0,12136051 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,10943552 0,12130202 ! chloride transport GO:0006821 67 48 0,000 0,11163192 0,12367699 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,11163192 0,12361744 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 0,000 0,11163192 0,12355795 ! response to temperature stimulus GO:0009266 62 48 0,000 0,11163192 0,12349852 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,11163192 0,12343915 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,11163192 0,12337983 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,11163192 0,12332057 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,11163192 0,12326136 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,11163192 0,12320222 ! regulation of endocytosis GO:0030100 63 48 0,000 0,11163192 0,12314313 ! nuclear export GO:0051168 69 48 0,000 0,11163192 0,12308409 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,11163192 0,12302512 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,11382303 0,12537978 ! sensory perception of smell GO:0007608 61 49 0,000 0,11382303 0,12531976 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,11382303 0,1252598 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,11382303 0,12519989 ! RNA elongation GO:0006354 62 49 0,000 0,11382303 0,12514005 ! germ cell development GO:0007281 68 49 0,000 0,11382303 0,12508026 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,11382303 0,12502052 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,11382303 0,12496085 ! regulation of actin filament length GO:0030832 72 50 0,000 0,11600887 0,1272998 ! ear development GO:0043583 72 50 0,000 0,11600887 0,1272391 ! membrane fusion GO:0006944 80 50 0,000 0,11600887 0,12717845 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,11600887 0,12711786 ! proton transport GO:0015992 75 50 0,000 0,11600887 0,12705733 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,11600887 0,12699685 ! positive regulation of secretion GO:0051047 71 51 0,000 0,11818943 0,1293224 ! hydrogen transport GO:0006818 77 51 0,000 0,11818943 0,12926091 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,11818943 0,12919947 ! adult behavior GO:0030534 80 51 0,000 0,11818943 0,1291381 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,11818943 0,12907678 ! transition metal ion transport GO:0000041 74 52 0,000 0,12036474 0,13139008 ! regulation of cellular component size GO:0032535 74 52 0,000 0,12036474 0,13132776 ! aging GO:0007568 79 52 0,000 0,12036474 0,13126548 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,12036474 0,13120327 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,12036474 0,13114112 ! establishment of organelle localization GO:0051656 85 52 0,000 0,12036474 0,13107903 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,12253481 0,13337911 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,12253481 0,13331602 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,12253481 0,13325299 ! single fertilization GO:0007338 59 53 0,000 0,12253481 0,13319001 ! cell projection assembly GO:0030031 76 53 0,000 0,12253481 0,1331271 ! amino acid transport GO:0006865 84 54 0,000 0,12469965 0,13541511 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,12469965 0,1353512 ! regulation of mitosis GO:0007088 84 54 0,000 0,12469965 0,13528736 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,12469965 0,13522357 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,12469965 0,13515985 ! DNA catabolic process GO:0006308 67 54 0,000 0,12469965 0,13509619 ! detection of external stimulus GO:0009581 66 54 0,000 0,12469965 0,13503258 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,12469965 0,13496904 ! exocytosis GO:0006887 74 55 0,000 0,12685928 0,13724193 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,12685928 0,1371774 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,12685928 0,13711294 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,12901369 0,139376 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,12901369 0,13931056 ! carbohydrate transport GO:0008643 74 57 0,000 0,13116292 0,14156486 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,13116292 0,14149846 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,13116292 0,14143212 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,13116292 0,14136585 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,13116292 0,14129963 ! camera-type eye development GO:0043010 88 57 0,000 0,13116292 0,14123348 ! secondary metabolic process GO:0019748 84 57 0,000 0,13116292 0,14116739 ! developmental maturation GO:0021700 75 57 0,000 0,13116292 0,14110136 ! gonad development GO:0008406 79 57 0,000 0,13116292 0,1410354 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,13330697 0,14327384 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,13330697 0,14320692 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,13330697 0,14314007 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,13544584 0,14536885 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,13544584 0,14530104 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,13544584 0,14523331 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,13757956 0,14745247 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,13757956 0,14738379 ! regulation of heart contraction GO:0008016 91 60 0,000 0,13757956 0,14731518 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,13757956 0,14724663 ! fertilization GO:0009566 68 60 0,000 0,13757956 0,14717814 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,13757956 0,14710972 ! meiosis GO:0007126 96 61 0,000 0,13970814 0,14931632 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 0,000 0,13970814 0,14924697 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,13970814 0,14917768 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,13970814 0,14910846 ! extracellular matrix organization GO:0030198 103 61 0,000 0,13970814 0,1490393 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,13970814 0,1489702 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,13970814 0,14890117 ! amine catabolic process GO:0009310 90 62 0,000 0,14183159 0,15109433 ! neurotransmitter transport GO:0006836 81 62 0,000 0,14183159 0,15102438 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,14183159 0,15095449 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,14183159 0,15088467 ! meiotic cell cycle GO:0051321 97 62 0,000 0,14183159 0,15081491 ! organelle localization GO:0051640 96 62 0,000 0,14183159 0,15074522 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,14394991 0,15292601 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,14606313 0,15509936 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,14606313 0,15502778 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,14606313 0,15495628 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,14606313 0,15488483 ! hexose catabolic process GO:0019320 82 64 0,000 0,14606313 0,15481346 ! adaptive immune response GO:0002250 94 64 0,000 0,14606313 0,15474215 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,14817126 0,15690326 ! B cell activation GO:0042113 104 65 0,000 0,14817126 0,15683106 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,14817126 0,15675892 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,14817126 0,15668685 ! defense response to bacterium GO:0042742 73 65 0,000 0,14817126 0,15661484 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,14817126 0,1565429 ! activation of immune response GO:0002253 83 65 0,000 0,14817126 0,15647102 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,1502743 0,15861904 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,1502743 0,15854627 ! antigen processing and presentation GO:0019882 96 66 0,000 0,1502743 0,15847358 ! regulation of immune effector process GO:0002697 101 66 0,000 0,1502743 0,15840095 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,15237226 0,1605388 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,15237226 0,1604653 ! acute inflammatory response GO:0002526 92 68 0,000 0,15446517 0,16259492 ! learning or memory GO:0007611 123 68 0,000 0,15446517 0,16252054 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,15446517 0,16244622 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,15446517 0,16237198 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,15446517 0,1622978 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,15446517 0,1622237 ! rhythmic process GO:0048511 105 68 0,000 0,15446517 0,16214965 ! inorganic anion transport GO:0015698 93 68 0,000 0,15446517 0,16207568 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,15655303 0,16419151 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,15655303 0,16411667 ! response to drug GO:0042493 108 69 0,000 0,15655303 0,1640419 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,15655303 0,1639672 ! response to metal ion GO:0010038 103 70 0,000 0,15863586 0,16607304 ! humoral immune response GO:0006959 86 70 0,000 0,15863586 0,16599748 ! eye development GO:0001654 111 70 0,000 0,15863586 0,165922 ! amine transport GO:0015837 101 70 0,000 0,15863586 0,16584658 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,15863586 0,16577123 ! muscle cell differentiation GO:0042692 104 71 0,000 0,16071366 0,16786622 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,16071366 0,16779002 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,16071366 0,16771389 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,16071366 0,16763783 ! response to hypoxia GO:0001666 132 72 0,000 0,16278644 0,16972295 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,16278644 0,16964604 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,16485423 0,17172316 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,16485423 0,17164542 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,16691703 0,17371456 ! response to oxygen levels GO:0070482 137 74 0,000 0,16691703 0,17363599 ! digestion GO:0007586 97 74 0,000 0,16691703 0,17355749 ! protein import into nucleus GO:0006606 118 74 0,000 0,16691703 0,17347906 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,16691703 0,17340071 ! blood coagulation GO:0007596 116 75 0,000 0,16897485 0,17545921 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,16897485 0,17538004 ! response to nutrient GO:0007584 104 75 0,000 0,16897485 0,17530093 ! regulation of ligase activity GO:0051340 114 75 0,000 0,16897485 0,17522189 ! nuclear import GO:0051170 121 75 0,000 0,16897485 0,17514293 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,16897485 0,17506404 ! amine biosynthetic process GO:0009309 97 76 0,000 0,17102771 0,17711109 ! tRNA metabolic process GO:0006399 95 76 0,000 0,17102771 0,17703138 ! response to unfolded protein GO:0006986 99 76 0,000 0,17102771 0,17695175 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,17102771 0,17687218 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,17307561 0,17890962 ! sex differentiation GO:0007548 105 77 0,000 0,17307561 0,17882925 ! protein ubiquitination GO:0016567 125 77 0,000 0,17307561 0,17874895 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,17307561 0,17866872 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,17307561 0,17858856 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,17307561 0,17850848 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,17511857 0,18053461 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,17511857 0,18045373 ! cellular respiration GO:0045333 107 79 0,000 0,17715661 0,1824721 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,17715661 0,18239042 ! T cell activation GO:0042110 134 79 0,000 0,17715661 0,18230881 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,17715661 0,18222728 ! chromatin assembly GO:0031497 102 80 0,000 0,17918972 0,18423619 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,17918972 0,18415387 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,17918972 0,18407162 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,17918972 0,18398944 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,17918972 0,18390734 ! forebrain development GO:0030900 131 80 0,000 0,17918972 0,18382531 ! hemostasis GO:0007599 125 81 0,000 0,18121793 0,18582311 ! mRNA transport GO:0051028 121 81 0,000 0,18121793 0,1857403 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,18121793 0,18565756 ! response to protein stimulus GO:0051789 111 81 0,000 0,18121793 0,1855749 ! regulation of neurological system process GO:0031644 122 81 0,000 0,18121793 0,18549231 ! vitamin metabolic process GO:0006766 103 81 0,000 0,18121793 0,1854098 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,18121793 0,18532736 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 0,000 0,18324124 0,18731326 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,18525966 0,18929241 ! regulation of defense response GO:0031347 117 84 0,000 0,18727322 0,19126483 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,18727322 0,19117994 ! sterol metabolic process GO:0016125 120 84 0,000 0,18727322 0,19109512 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,18928191 0,19305916 ! rRNA metabolic process GO:0016072 107 85 0,000 0,18928191 0,19297358 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,18928191 0,19288808 ! cell cycle arrest GO:0007050 150 86 0,000 0,19128576 0,19484377 ! nucleosome organization GO:0034728 114 87 0,000 0,19328476 0,19679281 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,19328476 0,19670573 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,19328476 0,19661873 ! female pregnancy GO:0007565 130 87 0,000 0,19328476 0,19653181 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,19328476 0,19644496 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,19527894 0,19838408 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,19527894 0,1982965 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,19527894 0,19820899 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,19527894 0,19812155 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,19527894 0,1980342 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,19726831 0,19996347 ! leukocyte differentiation GO:0002521 143 90 0,000 0,19925287 0,20188616 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,19925287 0,20179727 ! hormone metabolic process GO:0042445 121 90 0,000 0,19925287 0,20170845 ! RNA localization GO:0006403 135 91 0,000 0,20123263 0,20362299 ! ATP metabolic process GO:0046034 137 91 0,000 0,20123263 0,20353345 ! response to virus GO:0009615 122 91 0,000 0,20123263 0,20344398 ! positive regulation of immune response GO:0050778 121 92 0,000 0,20320762 0,20535041 ! DNA recombination GO:0006310 146 92 0,000 0,20320762 0,20526022 ! sulfur metabolic process GO:0006790 118 92 0,000 0,20320762 0,20517012 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,20517784 0,20706846 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,20517784 0,20697764 ! electron transport chain GO:0022900 123 94 0,000 0,2071433 0,20886873 ! response to oxidative stress GO:0006979 141 94 0,000 0,2071433 0,2087772 ! angiogenesis GO:0001525 149 95 0,000 0,20910401 0,21066107 ! carboxylic acid transport GO:0046942 147 95 0,000 0,20910401 0,21056883 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,21105998 0,2124455 ! in utero embryonic development GO:0001701 147 96 0,000 0,21105998 0,21235256 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,21105998 0,21225971 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,21105998 0,21216694 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,21105998 0,21207425 ! protein maturation GO:0051604 129 96 0,000 0,21105998 0,21198164 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,21301123 0,21384803 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,2168996 0,21765667 ! protein import GO:0017038 156 99 0,000 0,2168996 0,21756174 ! regulation of translation GO:0006417 151 100 0,000 0,21883674 0,21940911 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,21883674 0,21931351 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,21883674 0,21921799 ! divalent metal ion transport GO:0070838 171 100 0,000 0,21883674 0,21912255 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,21883674 0,2190272 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,21883674 0,21893193 ! protein localization in organelle GO:0033365 161 100 0,000 0,21883674 0,21883674