pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6331-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 10,000 2,137E-13 5,142E-10 ! negative regulation of phosphorylation GO:0042326 47 24 6,000 2,346E-10 2,822E-07 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 6,000 4,405E-10 3,533E-07 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of cell-matrix adhesion GO:0001953 36 11 4,000 7,186E-09 4,323E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! phospholipid dephosphorylation GO:0046839 12 5 3,000 1,164E-08 5,603E-06 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 3,474E-08 1,393E-05 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 3,000 8,062E-08 2,771E-05 ! negative regulation of focal adhesion formation GO:0051895 20 7 3,000 8,062E-08 2,425E-05 ! endothelial cell migration GO:0043542 28 17 4,000 9,301E-08 2,487E-05 ! cardiac muscle tissue development GO:0048738 31 17 4,000 9,301E-08 2,238E-05 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 3,000 1,604E-07 3,507E-05 ! regulation of focal adhesion formation GO:0051893 22 8 3,000 1,604E-07 3,215E-05 ! cellular response to insulin stimulus GO:0032869 82 37 5,000 2,136E-07 3,953E-05 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 3,000 2,87E-07 4,933E-05 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 3,000 4,758E-07 7,632E-05 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 3,000 4,758E-07 7,155E-05 ! regulation of cell-matrix adhesion GO:0001952 78 23 4,000 4,888E-07 6,917E-05 GO:0010810|regulation of cell-substrate adhesion, ! negative regulation of cell size GO:0045792 134 69 6,000 5,599E-07 7,484E-05 ! negative regulation of glucose import GO:0046325 17 11 3,000 7,436E-07 9,416E-05 GO:0010829|negative regulation of glucose transport, ! G1/S transition of mitotic cell cycle GO:0000082 115 46 5,000 8,166E-07 9,824E-05 ! response to insulin stimulus GO:0032868 95 46 5,000 8,166E-07 9,356E-05 ! insulin receptor signaling pathway GO:0008286 64 26 4,000 9,393E-07 1,027E-04 ! ribosomal large subunit biogenesis GO:0042273 13 13 3,000 1,593E-06 1,667E-04 ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 3,000 2,218E-06 2,224E-04 ! microvillus organization GO:0032528 7 5 2,000 3,355E-06 3,229E-04 GO:0030033|microvillus assembly, ! meiotic chromosome segregation GO:0045132 7 5 2,000 3,355E-06 3,105E-04 ! cellular anion homeostasis GO:0030002 9 5 2,000 3,355E-06 2,99E-04 GO:0055081|anion homeostasis, ! negative regulation of cell adhesion GO:0007162 81 35 4,000 4,404E-06 3,784E-04 ! response to peptide hormone stimulus GO:0043434 122 61 5,000 4,436E-06 3,68E-04 ! inositol metabolic process GO:0006020 28 17 3,000 5,188E-06 4,161E-04 ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 3,000 5,188E-06 4,027E-04 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 3,000 5,188E-06 3,901E-04 ! regulation of protein stability GO:0031647 73 37 4,000 5,846E-06 4,262E-04 ! establishment of spindle localization GO:0051293 12 6 2,000 6,676E-06 4,724E-04 GO:0051653|spindle localization, ! negative regulation of protein kinase activity GO:0006469 130 67 5,000 7,699E-06 5,292E-04 ! negative regulation of cell growth GO:0030308 132 67 5,000 7,699E-06 5,145E-04 ! negative regulation of kinase activity GO:0033673 131 68 5,000 8,395E-06 5,459E-04 ! apoptotic mitochondrial changes GO:0008637 41 20 3,000 1,039E-05 6,578E-04 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 3,000 1,039E-05 6,409E-04 ! regulation of glucose import GO:0046324 29 20 3,000 1,039E-05 6,249E-04 GO:0010827|regulation of glucose transport, ! fibrinolysis GO:0042730 10 7 2,000 1,162E-05 6,821E-04 ! negative regulation of transferase activity GO:0051348 140 72 5,000 1,171E-05 6,707E-04 ! induction of apoptosis by intracellular signals GO:0008629 93 45 4,000 1,566E-05 8,761E-04 ! negative regulation of cell migration GO:0030336 115 46 4,000 1,747E-05 9,551E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 2,000 1,85E-05 9,891E-04 ! ER overload response GO:0006983 12 8 2,000 1,85E-05 9,676E-04 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 1,85E-05 9,47E-04 ! regulation of mast cell proliferation GO:0070666 81 48 4,000 2,157E-05 1,081E-03 ! cellular response to hormone stimulus GO:0032870 167 82 5,000 2,476E-05 1,216E-03 ! induction of positive chemotaxis GO:0050930 15 9 2,000 2,761E-05 1,328E-03 ! negative regulation of growth GO:0045926 155 84 5,000 2,841E-05 1,34E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 4,000 2,909E-05 1,346E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! response to UV GO:0009411 104 53 4,000 3,514E-05 1,595E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 3,923E-05 1,748E-03 ! DNA ligation GO:0006266 19 10 2,000 3,923E-05 1,716E-03 ! regulation of cell adhesion GO:0030155 212 89 5,000 3,945E-05 1,695E-03 ! negative regulation of protein modification process GO:0031400 60 28 3,000 4,202E-05 1,774E-03 ! negative regulation of cell motion GO:0051271 134 55 4,000 4,212E-05 1,747E-03 ! lipid modification GO:0030258 97 57 4,000 5,012E-05 2,044E-03 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 2,000 5,367E-05 2,152E-03 ! chondrocyte differentiation GO:0002062 24 11 2,000 5,367E-05 2,117E-03 ! negative regulation of protein kinase cascade GO:0010741 68 30 3,000 5,563E-05 2,159E-03 ! interphase of mitotic cell cycle GO:0051329 209 95 5,000 5,698E-05 2,176E-03 ! protein amino acid autophosphorylation GO:0046777 141 60 4,000 6,427E-05 2,416E-03 ! negative regulation of response to stimulus GO:0048585 100 60 4,000 6,427E-05 2,379E-03 ! interphase GO:0051325 213 98 5,000 6,782E-05 2,472E-03 ! positive regulation of cellular catabolic process GO:0031331 31 12 2,000 7,119E-05 2,556E-03 ! regulation of B cell proliferation GO:0030888 20 12 2,000 7,119E-05 2,519E-03 ! regulation of positive chemotaxis GO:0050926 19 12 2,000 7,119E-05 2,482E-03 GO:0050927|positive regulation of positive chemotaxis, ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 7,119E-05 2,447E-03 GO:0042130|negative regulation of T cell proliferation, ! cell cycle arrest GO:0007050 213 100 5,000 7,592E-05 2,573E-03 ! regulation of monooxygenase activity GO:0032768 33 13 2,000 9,207E-05 3,077E-03 ! chromosome segregation GO:0007059 113 67 4,000 1,092E-04 3,6E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 4,000 1,092E-04 3,552E-03 ! oxygen transport GO:0015671 21 14 2,000 1,166E-04 3,74E-03 ! cell cycle checkpoint GO:0000075 137 69 4,000 1,257E-04 3,979E-03 ! regulation of the force of heart contraction GO:0002026 26 15 2,000 1,45E-04 4,53E-03 ! G1/S transition checkpoint GO:0031575 40 15 2,000 1,45E-04 4,471E-03 ! phosphoinositide metabolic process GO:0030384 128 72 4,000 1,538E-04 4,685E-03 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 2,000 1,775E-04 5,338E-03 ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 1,775E-04 5,272E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 2,000 1,775E-04 5,208E-03 ! regulation of T cell proliferation GO:0042129 71 41 3,000 1,935E-04 5,61E-03 ! regulation of T cell differentiation GO:0045580 70 41 3,000 1,935E-04 5,543E-03 ! polyol metabolic process GO:0019751 66 41 3,000 1,935E-04 5,478E-03 ! neutrophil chemotaxis GO:0030593 27 17 2,000 2,144E-04 5,999E-03 ! negative regulation of blood coagulation GO:0030195 24 17 2,000 2,144E-04 5,93E-03 ! gas transport GO:0015669 25 17 2,000 2,144E-04 5,862E-03 ! positive regulation of phosphorylation GO:0042327 129 79 4,000 2,382E-04 6,438E-03 ! protein import into nucleus GO:0006606 158 80 4,000 2,526E-04 6,753E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 2,56E-04 6,768E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 2,000 2,56E-04 6,694E-03 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 4,000 2,677E-04 6,926E-03 GO:0045937|positive regulation of phosphate metabolic process, ! nuclear import GO:0051170 161 81 4,000 2,677E-04 6,852E-03 ! leukocyte migration GO:0050900 68 45 3,000 2,786E-04 7,055E-03 ! regulation of carbohydrate metabolic process GO:0006109 38 20 2,000 3,539E-04 8,87E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! peptidyl-serine modification GO:0018209 43 20 2,000 3,539E-04 8,779E-03 ! negative regulation of T cell activation GO:0050868 40 20 2,000 3,539E-04 8,689E-03 ! negative regulation of coagulation GO:0050819 29 20 2,000 3,539E-04 8,602E-03 ! positive regulation of cell cycle GO:0045787 89 48 3,000 3,579E-04 8,611E-03 ! regulation of inflammatory response GO:0050727 75 48 3,000 3,579E-04 8,525E-03 ! regulation of lymphocyte differentiation GO:0045619 81 48 3,000 3,579E-04 8,442E-03 ! protein localization in nucleus GO:0034504 176 87 4,000 3,732E-04 8,718E-03 ! inactivation of MAPK activity GO:0000188 39 21 2,000 4,108E-04 9,503E-03 ! positive regulation of locomotion GO:0040017 39 21 2,000 4,108E-04 9,413E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 35 21 2,000 4,108E-04 9,324E-03 ! regulation of chemotaxis GO:0050920 40 22 2,000 4,732E-04 0,01064037 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 4,732E-04 0,01054185 ! apoptotic nuclear changes GO:0030262 32 22 2,000 4,732E-04 0,01044513 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 2,000 4,732E-04 0,01035018 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 1,000 4,818E-04 0,01044303 ! positive regulation of glycolysis GO:0045821 14 5 1,000 4,818E-04 0,01034979 ! anagen GO:0042640 6 5 1,000 4,818E-04 0,0102582 ! positive regulation of viral genome replication GO:0045070 9 5 1,000 4,818E-04 0,01016822 ! skeletal myofibril assembly GO:0014866 10 5 1,000 4,818E-04 0,0100798 ! cardiac muscle fiber development GO:0048739 10 5 1,000 4,818E-04 9,993E-03 ! regulation of retroviral genome replication GO:0045091 7 5 1,000 4,818E-04 9,907E-03 ! muscle cell migration GO:0014812 8 5 1,000 4,818E-04 9,824E-03 ! response to food GO:0032094 6 5 1,000 4,818E-04 9,741E-03 ! morphogenesis of an epithelial sheet GO:0002011 11 5 1,000 4,818E-04 9,66E-03 ! regulation of glycogen metabolic process GO:0070873 11 5 1,000 4,818E-04 9,58E-03 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 4,818E-04 9,501E-03 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 1,000 4,818E-04 9,424E-03 ! base-excision repair, DNA ligation GO:0006288 7 5 1,000 4,818E-04 9,348E-03 ! metaphase GO:0051323 8 5 1,000 4,818E-04 9,273E-03 ! stem cell division GO:0017145 11 5 1,000 4,818E-04 9,2E-03 GO:0048103|somatic stem cell division, ! carnitine metabolic process GO:0009437 7 5 1,000 4,818E-04 9,127E-03 GO:0006577|betaine metabolic process, ! regulation of angiogenesis GO:0045765 114 52 3,000 4,872E-04 9,157E-03 ! sex determination GO:0007530 47 23 2,000 5,414E-04 0,01009734 ! protein import into nucleus, translocation GO:0000060 46 24 2,000 6,155E-04 0,01139211 ! regulation of cellular catabolic process GO:0031329 52 24 2,000 6,155E-04 0,01130515 ! regulation of behavior GO:0050795 43 24 2,000 6,155E-04 0,01121951 ! regulation of oxidoreductase activity GO:0051341 46 24 2,000 6,155E-04 0,01113515 ! protein tetramerization GO:0051262 52 24 2,000 6,155E-04 0,01105205 ! positive regulation of cell migration GO:0030335 126 57 3,000 6,917E-04 0,01232763 ! chromosome condensation GO:0030261 45 25 2,000 6,959E-04 0,01231079 ! response to endoplasmic reticulum stress GO:0034976 43 25 2,000 6,959E-04 0,01222093 ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 2,000 6,959E-04 0,01213237 ! regulation of blood coagulation GO:0030193 40 25 2,000 6,959E-04 0,01204509 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 1,000 7,193E-04 0,01236239 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 1,000 7,193E-04 0,01227471 ! male sex determination GO:0030238 15 6 1,000 7,193E-04 0,01218827 ! carnitine transport GO:0015879 10 6 1,000 7,193E-04 0,01210303 GO:0015838|betaine transport, ! monocyte differentiation GO:0030224 12 6 1,000 7,193E-04 0,01201899 ! neural nucleus development GO:0048857 14 6 1,000 7,193E-04 0,0119361 ! nucleoside catabolic process GO:0009164 7 6 1,000 7,193E-04 0,01185434 ! hair follicle maturation GO:0048820 7 6 1,000 7,193E-04 0,0117737 ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 7,193E-04 0,01169415 ! cytoplasmic microtubule organization GO:0031122 14 6 1,000 7,193E-04 0,01161566 ! negative regulation of B cell activation GO:0050869 13 6 1,000 7,193E-04 0,01153823 ! molting cycle process GO:0022404 50 26 2,000 7,826E-04 0,01246964 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! integrin-mediated signaling pathway GO:0007229 135 59 3,000 7,883E-04 0,01247836 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 8,759E-04 0,01377378 ! base-excision repair GO:0006284 41 27 2,000 8,759E-04 0,01368434 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 8,759E-04 0,01359606 ! ER-nuclear signaling pathway GO:0006984 48 28 2,000 9,76E-04 0,01505221 ! regulation of helicase activity GO:0051095 15 7 1,000 1,002E-03 0,01536205 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 1,000 1,002E-03 0,01526482 ! regulation of lipid kinase activity GO:0043550 13 7 1,000 1,002E-03 0,01516882 ! Golgi to plasma membrane transport GO:0006893 14 7 1,000 1,002E-03 0,01507401 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,002E-03 0,01498038 ! neuron adhesion GO:0007158 12 7 1,000 1,002E-03 0,01488791 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 1,002E-03 0,01479658 ! DNA ligation during DNA repair GO:0051103 13 7 1,000 1,002E-03 0,01470635 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 1,000 1,002E-03 0,01461722 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! centrosome duplication GO:0051298 13 7 1,000 1,002E-03 0,01452917 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 1,002E-03 0,01444217 ! B cell lineage commitment GO:0002326 21 7 1,000 1,002E-03 0,0143562 ! cranial nerve morphogenesis GO:0021602 11 7 1,000 1,002E-03 0,01427125 ! positive regulation of monooxygenase activity GO:0032770 12 7 1,000 1,002E-03 0,0141873 ! T cell lineage commitment GO:0002360 16 7 1,000 1,002E-03 0,01410434 ! response to tumor cell GO:0002347 13 7 1,000 1,002E-03 0,01402234 ! regulation of respiratory burst GO:0060263 11 7 1,000 1,002E-03 0,01394128 ! axonal fasciculation GO:0007413 18 7 1,000 1,002E-03 0,01386116 ! positive regulation of cell motion GO:0051272 146 64 3,000 1,071E-03 0,01472423 ! cellular response to extracellular stimulus GO:0031668 48 29 2,000 1,083E-03 0,0148047 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 2,000 1,083E-03 0,01472106 ! regulation of coagulation GO:0050818 46 29 2,000 1,083E-03 0,01463835 ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 1,197E-03 0,0160909 ! regulation of B cell activation GO:0050864 50 30 2,000 1,197E-03 0,0160015 ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 1,000 1,33E-03 0,01768482 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,33E-03 0,01758765 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,33E-03 0,01749154 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 1,000 1,33E-03 0,01739648 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 1,000 1,33E-03 0,01730244 ! DNA topological change GO:0006265 12 8 1,000 1,33E-03 0,01720942 ! regulation of fat cell differentiation GO:0045598 15 8 1,000 1,33E-03 0,01711739 ! nucleosome disassembly GO:0006337 14 8 1,000 1,33E-03 0,01702634 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! spindle organization GO:0007051 46 32 2,000 1,448E-03 0,01842708 ! negative regulation of MAP kinase activity GO:0043407 69 32 2,000 1,448E-03 0,01833009 ! positive regulation of catabolic process GO:0009896 64 32 2,000 1,448E-03 0,01823412 ! cell fate specification GO:0001708 52 33 2,000 1,584E-03 0,01985069 ! leukocyte chemotaxis GO:0030595 50 33 2,000 1,584E-03 0,01974783 GO:0060326|cell chemotaxis, ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 3,000 1,66E-03 0,0205904 ! regulation of developmental growth GO:0048638 15 9 1,000 1,703E-03 0,02100786 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 1,703E-03 0,02090067 ! elastic fiber assembly GO:0048251 15 9 1,000 1,703E-03 0,02079458 ! regulation of glycolysis GO:0006110 21 9 1,000 1,703E-03 0,02068956 ! microtubule bundle formation GO:0001578 21 9 1,000 1,703E-03 0,02058559 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 1,000 1,703E-03 0,02048266 ! motor axon guidance GO:0008045 16 9 1,000 1,703E-03 0,02038076 ! protein heterooligomerization GO:0051291 16 9 1,000 1,703E-03 0,02027986 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 1,000 1,703E-03 0,02017996 ! induction of an organ GO:0001759 14 9 1,000 1,703E-03 0,02008104 ! meiosis GO:0007126 121 74 3,000 1,837E-03 0,0215576 GO:0051327|M phase of meiotic cell cycle, ! calcium-mediated signaling GO:0019722 62 35 2,000 1,881E-03 0,0219674 ! regulation of microtubule-based process GO:0032886 78 35 2,000 1,881E-03 0,02186128 ! phosphoinositide-mediated signaling GO:0048015 131 75 3,000 1,93E-03 0,02232209 ! meiotic cell cycle GO:0051321 122 75 3,000 1,93E-03 0,02221528 ! regulation of catabolic process GO:0009894 161 76 3,000 2,026E-03 0,02321141 ! mitotic sister chromatid segregation GO:0000070 57 36 2,000 2,041E-03 0,02327663 ! regulation of proteolysis GO:0030162 72 36 2,000 2,041E-03 0,02316684 ! negative regulation of cell activation GO:0050866 65 36 2,000 2,041E-03 0,02305807 ! positive regulation of B cell proliferation GO:0030890 16 10 1,000 2,118E-03 0,02381807 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 2,118E-03 0,02370728 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 1,000 2,118E-03 0,02359753 GO:0007520|myoblast fusion, ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 1,000 2,118E-03 0,02348878 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 1,000 2,118E-03 0,02338104 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 1,000 2,118E-03 0,02327427 ! glucan biosynthetic process GO:0009250 14 10 1,000 2,118E-03 0,02316848 GO:0005978|glycogen biosynthetic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 2,118E-03 0,02306365 ! apical protein localization GO:0045176 15 10 1,000 2,118E-03 0,02295976 ! quaternary ammonium group transport GO:0015697 21 10 1,000 2,118E-03 0,0228568 ! positive regulation of viral reproduction GO:0048524 18 10 1,000 2,118E-03 0,02275476 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 1,000 2,118E-03 0,02265363 GO:0043470|regulation of carbohydrate catabolic process, ! establishment of cell polarity GO:0030010 16 10 1,000 2,118E-03 0,02255339 ! localization within membrane GO:0051668 20 10 1,000 2,118E-03 0,02245404 ! meiosis I GO:0007127 65 37 2,000 2,21E-03 0,02332166 ! establishment or maintenance of cell polarity GO:0007163 83 37 2,000 2,21E-03 0,02321981 ! sister chromatid segregation GO:0000819 58 37 2,000 2,21E-03 0,02311886 ! glycogen metabolic process GO:0005977 61 37 2,000 2,21E-03 0,02301878 ! negative regulation of organelle organization GO:0010639 161 78 3,000 2,228E-03 0,02310725 ! mitotic cell cycle checkpoint GO:0007093 76 38 2,000 2,387E-03 0,02465037 ! nucleus organization GO:0006997 67 38 2,000 2,387E-03 0,02454503 ! positive regulation of leukocyte proliferation GO:0070665 62 38 2,000 2,387E-03 0,02444058 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! glucan metabolic process GO:0044042 62 38 2,000 2,387E-03 0,02433702 GO:0006073|cellular glucan metabolic process, ! mammary gland development GO:0030879 86 39 2,000 2,573E-03 0,02611942 ! cortical actin cytoskeleton organization GO:0030866 30 11 1,000 2,577E-03 0,02605484 ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 2,577E-03 0,02594583 ! negative regulation of proteolysis GO:0045861 25 11 1,000 2,577E-03 0,02583772 ! syncytium formation GO:0006949 18 11 1,000 2,577E-03 0,02573051 ! regulation of intracellular pH GO:0051453 19 11 1,000 2,577E-03 0,02562419 ! negative regulation of ossification GO:0030279 26 11 1,000 2,577E-03 0,02551874 ! developmental induction GO:0031128 19 11 1,000 2,577E-03 0,02541415 GO:0045168|cell-cell signaling involved in cell fate specification, ! regulation of embryonic development GO:0045995 27 11 1,000 2,577E-03 0,02531042 ! cytokinesis GO:0000910 72 40 2,000 2,767E-03 0,02706488 ! negative regulation of transport GO:0051051 153 84 3,000 2,917E-03 0,02841858 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 1,000 3,079E-03 0,02986697 ! cortical cytoskeleton organization GO:0030865 31 12 1,000 3,079E-03 0,02974702 ! virus-host interaction GO:0019048 29 12 1,000 3,079E-03 0,02962803 ! oligodendrocyte differentiation GO:0048709 16 12 1,000 3,079E-03 0,02950999 ! asymmetric protein localization GO:0008105 20 12 1,000 3,079E-03 0,02939289 ! membrane protein proteolysis GO:0033619 25 12 1,000 3,079E-03 0,02927671 GO:0006509|membrane protein ectodomain proteolysis, ! cranial nerve development GO:0021545 20 12 1,000 3,079E-03 0,02916145 ! histone acetylation GO:0016573 26 12 1,000 3,079E-03 0,02904709 ! mRNA polyadenylation GO:0006378 23 12 1,000 3,079E-03 0,02893362 ! autonomic nervous system development GO:0048483 24 12 1,000 3,079E-03 0,02882104 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,079E-03 0,02870933 ! T cell homeostasis GO:0043029 25 12 1,000 3,079E-03 0,02859849 ! mitochondrion organization GO:0007005 148 86 3,000 3,176E-03 0,02939259 ! negative regulation of protein complex disassembly GO:0043242 101 42 2,000 3,183E-03 0,02933798 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 2,000 3,183E-03 0,029226 ! energy reserve metabolic process GO:0006112 74 43 2,000 3,404E-03 0,03113843 ! positive regulation of response to external stimulus GO:0032103 77 43 2,000 3,404E-03 0,03102048 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 3,404E-03 0,03090343 ! positive regulation of protein modification process GO:0031401 136 88 3,000 3,45E-03 0,03120826 ! lipid localization GO:0010876 28 13 1,000 3,622E-03 0,03263469 GO:0019915|lipid storage, ! response to X-ray GO:0010165 25 13 1,000 3,622E-03 0,03251292 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 1,000 3,622E-03 0,03239205 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 3,622E-03 0,03227208 ! nucleoside triphosphate catabolic process GO:0009143 21 13 1,000 3,622E-03 0,032153 ! regulation of cellular pH GO:0030641 22 13 1,000 3,622E-03 0,03203479 ! mRNA 3'-end processing GO:0031124 24 13 1,000 3,622E-03 0,03191744 ! regulation of defense response GO:0031347 149 92 3,000 4,046E-03 0,03552555 ! regulation of gene-specific transcription GO:0032583 96 46 2,000 4,123E-03 0,03607165 ! positive regulation of MAP kinase activity GO:0043406 160 93 3,000 4,205E-03 0,0366544 ! negative regulation of multicellular organismal process GO:0051241 166 93 3,000 4,205E-03 0,03652207 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 4,206E-03 0,03639914 ! myotube differentiation GO:0014902 25 14 1,000 4,206E-03 0,03626868 ! hair follicle morphogenesis GO:0031069 26 14 1,000 4,206E-03 0,03613915 ! RNA polyadenylation GO:0043631 30 14 1,000 4,206E-03 0,03601054 ! actin cytoskeleton reorganization GO:0031532 33 14 1,000 4,206E-03 0,03588284 ! response to gamma radiation GO:0010332 28 14 1,000 4,206E-03 0,03575605 ! cofactor transport GO:0051181 26 14 1,000 4,206E-03 0,03563015 ! regulation of RNA stability GO:0043487 32 14 1,000 4,206E-03 0,03550513 ! release of cytochrome c from mitochondria GO:0001836 30 14 1,000 4,206E-03 0,03538098 ! regulation of T cell activation GO:0050863 158 94 3,000 4,368E-03 0,03661761 ! positive regulation of defense response GO:0031349 76 47 2,000 4,382E-03 0,03660394 ! cellular component disassembly GO:0022411 86 48 2,000 4,65E-03 0,03871047 ! activation of caspase activity GO:0006919 84 48 2,000 4,65E-03 0,03857699 ! negative regulation of bone remodeling GO:0046851 33 15 1,000 4,83E-03 0,03993837 ! copper ion transport GO:0006825 20 15 1,000 4,83E-03 0,0398016 ! heterophilic cell adhesion GO:0007157 39 15 1,000 4,83E-03 0,03966576 ! regulation of transmembrane transporter activity GO:0022898 27 15 1,000 4,83E-03 0,03953084 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 1,000 4,83E-03 0,03939684 ! intermediate filament cytoskeleton organization GO:0045104 31 15 1,000 4,83E-03 0,03926374 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 4,83E-03 0,03913154 ! lymphocyte homeostasis GO:0002260 30 15 1,000 4,83E-03 0,03900023 ! regulation of protein complex disassembly GO:0043244 113 49 2,000 4,928E-03 0,03965257 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 4,928E-03 0,0395204 ! DNA-dependent DNA replication GO:0006261 74 49 2,000 4,928E-03 0,0393891 ! negative regulation of immune system process GO:0002683 95 50 2,000 5,216E-03 0,04155148 ! skeletal muscle tissue development GO:0007519 186 99 3,000 5,248E-03 0,04167337 GO:0060538|skeletal muscle organ development, ! regulation of glucose metabolic process GO:0010906 28 16 1,000 5,495E-03 0,0434913 ! bone remodeling GO:0046849 27 16 1,000 5,495E-03 0,04334871 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 5,495E-03 0,04320705 GO:0031114|regulation of microtubule depolymerization, ! intermediate filament-based process GO:0045103 32 16 1,000 5,495E-03 0,04306631 ! axon cargo transport GO:0008088 43 16 1,000 5,495E-03 0,04292648 ! DNA replication initiation GO:0006270 27 16 1,000 5,495E-03 0,04278756 ! neuron recognition GO:0008038 35 16 1,000 5,495E-03 0,04264954 ! negative regulation of inflammatory response GO:0050728 22 16 1,000 5,495E-03 0,0425124 ! negative regulation of tissue remodeling GO:0034104 36 16 1,000 5,495E-03 0,04237614 ! chromatin remodeling GO:0006338 109 51 2,000 5,513E-03 0,04237967 ! regulation of muscle contraction GO:0006937 81 52 2,000 5,821E-03 0,04460257 ! positive regulation of growth GO:0045927 90 52 2,000 5,821E-03 0,04446097 ! cartilage development GO:0051216 90 52 2,000 5,821E-03 0,04432027 ! synapse organization GO:0050808 85 52 2,000 5,821E-03 0,04418046 ! regulation of neuron apoptosis GO:0043523 100 53 2,000 6,139E-03 0,04644611 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 6,199E-03 0,0467568 ! regulation of viral genome replication GO:0045069 28 17 1,000 6,199E-03 0,04661069 ! regulation of survival gene product expression GO:0045884 33 17 1,000 6,199E-03 0,04646548 ! negative regulation of protein catabolic process GO:0042177 40 17 1,000 6,199E-03 0,04632118 ! DNA unwinding during replication GO:0006268 27 17 1,000 6,199E-03 0,04617777 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 1,000 6,199E-03 0,04603525 ! organic cation transport GO:0015695 31 17 1,000 6,199E-03 0,0458936 ! RNA 3'-end processing GO:0031123 34 17 1,000 6,199E-03 0,04575282 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 6,199E-03 0,0456129 ! negative regulation of cytoskeleton organization GO:0051494 124 54 2,000 6,467E-03 0,047436 ! positive regulation of caspase activity GO:0043280 95 55 2,000 6,805E-03 0,04976546 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 86 55 2,000 6,805E-03 0,04961465 ! regulation of protein catabolic process GO:0042176 116 55 2,000 6,805E-03 0,04946476 ! aging GO:0007568 103 55 2,000 6,805E-03 0,04931577 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 6,942E-03 0,05015875 ! centrosome cycle GO:0007098 25 18 1,000 6,942E-03 0,05000858 ! positive regulation of proteolysis GO:0045862 31 18 1,000 6,942E-03 0,0498593 ! epidermis morphogenesis GO:0048730 40 18 1,000 6,942E-03 0,04971091 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 1,000 6,942E-03 0,04956339 ! vitamin transport GO:0051180 27 18 1,000 6,942E-03 0,04941676 ! nerve development GO:0021675 28 18 1,000 6,942E-03 0,04927099 ! skeletal muscle fiber development GO:0048741 111 56 2,000 7,154E-03 0,05062215 ! regulation of DNA replication GO:0006275 101 56 2,000 7,154E-03 0,0504737 ! muscle fiber development GO:0048747 112 57 2,000 7,513E-03 0,05285166 ! negative regulation of defense response GO:0031348 25 19 1,000 7,723E-03 0,05417583 ! positive regulation of angiogenesis GO:0045766 44 19 1,000 7,723E-03 0,05401835 ! lipid phosphorylation GO:0046834 35 19 1,000 7,723E-03 0,05386177 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 1,000 7,723E-03 0,0537061 ! mitotic chromosome condensation GO:0007076 34 19 1,000 7,723E-03 0,05355133 ! neuromuscular junction development GO:0007528 34 19 1,000 7,723E-03 0,05339744 ! plasma membrane fusion GO:0045026 28 19 1,000 7,723E-03 0,05324444 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 1,000 7,723E-03 0,05309232 ! establishment of organelle localization GO:0051656 109 59 2,000 8,262E-03 0,05663406 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 1,000 8,542E-03 0,05838749 ! protein amino acid acetylation GO:0006473 39 20 1,000 8,542E-03 0,05822208 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 1,000 8,542E-03 0,05805761 ! DNA duplex unwinding GO:0032508 31 20 1,000 8,542E-03 0,05789407 GO:0032392|DNA geometric change, ! cellular response to starvation GO:0009267 33 20 1,000 8,542E-03 0,05773145 ! body fluid secretion GO:0007589 31 20 1,000 8,542E-03 0,05756973 ! actin filament-based movement GO:0030048 43 20 1,000 8,542E-03 0,05740893 ! negative regulation of translation GO:0017148 29 20 1,000 8,542E-03 0,05724901 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 1,000 8,542E-03 0,05708999 ! regulation of heart contraction GO:0008016 110 60 2,000 8,653E-03 0,05766875 ! mesoderm development GO:0007498 119 61 2,000 9,054E-03 0,06017669 ! smooth muscle contraction GO:0006939 46 21 1,000 9,398E-03 0,06229137 ! cellular macromolecular complex disassembly GO:0034623 43 21 1,000 9,398E-03 0,06212024 ! cell structure disassembly during apoptosis GO:0006921 30 21 1,000 9,398E-03 0,06195005 ! cell aging GO:0007569 44 21 1,000 9,398E-03 0,06178079 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 1,000 9,398E-03 0,06161245 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 1,000 9,398E-03 0,06144502 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 1,000 9,398E-03 0,0612785 ! DNA modification GO:0006304 34 21 1,000 9,398E-03 0,06111289 ! viral reproductive process GO:0022415 126 62 2,000 9,466E-03 0,06138902 ! positive regulation of protein catabolic process GO:0045732 38 22 1,000 0,01029056 0,0665567 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 1,000 0,01029056 0,06637826 ! microtubule-based transport GO:0010970 54 22 1,000 0,01029056 0,06620078 ! glutamate signaling pathway GO:0007215 41 22 1,000 0,01029056 0,06602425 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 0,01029056 0,06584865 ! positive regulation of intracellular transport GO:0032388 37 22 1,000 0,01029056 0,06567399 ! positive regulation of B cell activation GO:0050871 38 22 1,000 0,01029056 0,06550024 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 1,000 0,01029056 0,06532742 ! germ cell development GO:0007281 118 65 2,000 0,01076711 0,0681728 ! positive regulation of DNA replication GO:0045740 43 23 1,000 0,01121906 0,0708479 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 1,000 0,01121906 0,07066243 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 0,01121906 0,07047793 ! myeloid leukocyte differentiation GO:0002573 40 23 1,000 0,01121906 0,0702944 ! viral genome replication GO:0019079 41 23 1,000 0,01121906 0,07011181 ! activation of pro-apoptotic gene products GO:0008633 47 23 1,000 0,01121906 0,06993018 ! purine ribonucleoside metabolic process GO:0046128 34 23 1,000 0,01121906 0,06974948 GO:0042278|purine nucleoside metabolic process, ! barbed-end actin filament capping GO:0051016 50 23 1,000 0,01121906 0,06956971 GO:0051693|actin filament capping, ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 1,000 0,01121906 0,06939087 ! regulation of viral reproduction GO:0050792 38 23 1,000 0,01121906 0,06921294 ! regulation of bone mineralization GO:0030500 49 23 1,000 0,01121906 0,06903593 ! negative regulation of catabolic process GO:0009895 50 23 1,000 0,01121906 0,06885982 ! extracellular matrix organization GO:0030198 133 66 2,000 0,01122261 0,06870634 ! cell projection assembly GO:0030031 120 66 2,000 0,01122261 0,06853196 ! lung development GO:0030324 144 67 2,000 0,01168909 0,07119986 ! viral reproduction GO:0016032 134 68 2,000 0,01216659 0,07392127 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 0,01218301 0,07383458 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 1,000 0,01218301 0,07364906 ! regulation of transmembrane transport GO:0034762 38 24 1,000 0,01218301 0,07346448 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 1,000 0,01218301 0,07328082 ! regulation of alpha-beta T cell activation GO:0046634 42 24 1,000 0,01218301 0,07309807 ! leukocyte homeostasis GO:0001776 44 24 1,000 0,01218301 0,07291624 ! respiratory tube development GO:0030323 150 70 2,000 0,01315483 0,07853729 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 1,000 0,01318189 0,07850405 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 1,000 0,01318189 0,07831022 ! myelination GO:0042552 45 25 1,000 0,01318189 0,07811733 ! vasculogenesis GO:0001570 46 25 1,000 0,01318189 0,0779254 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 1,000 0,01318189 0,07773441 ! negative regulation of DNA replication GO:0008156 42 25 1,000 0,01318189 0,07754435 ! response to starvation GO:0042594 42 25 1,000 0,01318189 0,07735521 ! negative regulation of cell development GO:0010721 73 25 1,000 0,01318189 0,077167 GO:0050768|negative regulation of neurogenesis, ! interaction with host GO:0051701 62 25 1,000 0,01318189 0,0769797 ! regulation of biomineral formation GO:0070167 51 25 1,000 0,01318189 0,07679331 ! somitogenesis GO:0001756 43 25 1,000 0,01318189 0,07660782 ! cellular response to nutrient levels GO:0031669 41 25 1,000 0,01318189 0,07642322 ! regulation of caspase activity GO:0043281 122 72 2,000 0,01418761 0,08205625 ! respiratory system development GO:0060541 153 72 2,000 0,01418761 0,08185947 ! negative regulation of actin filament depolymerization GO:0030835 55 26 1,000 0,01421517 0,08182224 ! negative regulation of actin filament polymerization GO:0030837 53 26 1,000 0,01421517 0,08162696 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 1,000 0,01421517 0,08143261 ! macromolecular complex disassembly GO:0032984 53 26 1,000 0,01421517 0,08123919 ! microtubule organizing center organization GO:0031023 39 26 1,000 0,01421517 0,08104668 GO:0051297|centrosome organization, ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 1,000 0,01421517 0,08085508 ! positive regulation of nuclear division GO:0051785 40 26 1,000 0,01421517 0,08066438 GO:0045840|positive regulation of mitosis, ! axon guidance GO:0007411 139 73 2,000 0,01472078 0,08333696 ! regulation of transcription factor activity GO:0051090 126 74 2,000 0,01526518 0,08621601 GO:0090046|regulation of transcription regulator activity, ! regulation of endopeptidase activity GO:0052548 125 74 2,000 0,01526518 0,0860141 ! organelle localization GO:0051640 136 74 2,000 0,01526518 0,08581313 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 1,000 0,01528231 0,08570919 ! protein amino acid acylation GO:0043543 55 27 1,000 0,01528231 0,08550987 ! mitochondrial membrane organization GO:0007006 57 27 1,000 0,01528231 0,08531147 ! male gonad development GO:0008584 44 27 1,000 0,01528231 0,08511399 ! regulation of chromosome organization GO:0033044 42 27 1,000 0,01528231 0,08491742 ! negative regulation of protein polymerization GO:0032272 55 27 1,000 0,01528231 0,08472176 ! regulation of actin filament depolymerization GO:0030834 58 28 1,000 0,0163828 0,09061384 ! dendrite development GO:0016358 59 28 1,000 0,0163828 0,09040601 ! positive regulation of T cell differentiation GO:0045582 42 28 1,000 0,0163828 0,09019913 ! synaptogenesis GO:0007416 42 28 1,000 0,0163828 0,08999319 ! peptidyl-tyrosine modification GO:0018212 50 28 1,000 0,0163828 0,0897882 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 0,01696594 0,09277284 ! negative regulation of protein complex assembly GO:0031333 59 29 1,000 0,01751612 0,09556415 ! regulation of pH GO:0006885 43 29 1,000 0,01751612 0,09534794 ! blood coagulation GO:0007596 146 78 2,000 0,01755545 0,09534631 GO:0050817|coagulation, ! protein oligomerization GO:0051259 139 78 2,000 0,01755545 0,09513157 ! regulation of peptidase activity GO:0052547 134 79 2,000 0,01815629 0,09816636 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 2,000 0,01815629 0,09794625 ! myofibril assembly GO:0030239 47 30 1,000 0,01868176 0,10055554 GO:0055002|striated muscle cell development, ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 0,01868176 0,10033108 ! ensheathment of neurons GO:0007272 57 30 1,000 0,01868176 0,10010763 GO:0008366|axon ensheathment, ! response to heat GO:0009408 50 30 1,000 0,01868176 0,09988517 ! muscle cell differentiation GO:0042692 159 80 2,000 0,01876846 0,10012621 ! inorganic anion transport GO:0015698 138 80 2,000 0,01876846 0,09990469 ! T cell activation GO:0042110 168 81 2,000 0,01939198 0,10299584 ! response to hypoxia GO:0001666 171 81 2,000 0,01939198 0,10276898 ! regulation of neuron differentiation GO:0045664 167 81 2,000 0,01939198 0,10254311 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 1,000 0,01987923 0,10488907 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 1,000 0,01987923 0,10465956 ! positive regulation of T cell proliferation GO:0042102 52 31 1,000 0,01987923 0,10443104 ! triglyceride metabolic process GO:0006641 43 31 1,000 0,01987923 0,10420352 ! mesoderm formation GO:0001707 69 31 1,000 0,01987923 0,10397699 ! negative regulation of transcription regulator activity GO:0090048 58 31 1,000 0,01987923 0,10375145 GO:0043433|negative regulation of transcription factor activity, ! response to oxygen levels GO:0070482 176 83 2,000 0,02067311 0,10766127 ! negative regulation of response to external stimulus GO:0032102 47 32 1,000 0,02110801 0,10968869 ! metanephros development GO:0001656 74 32 1,000 0,02110801 0,10945229 ! response to ionizing radiation GO:0010212 65 32 1,000 0,02110801 0,10921691 ! muscle cell development GO:0055001 49 32 1,000 0,02110801 0,10898254 ! peripheral nervous system development GO:0007422 64 32 1,000 0,02110801 0,10874917 ! hindbrain development GO:0030902 61 32 1,000 0,02110801 0,1085168 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 1,000 0,02110801 0,10828542 ! hemostasis GO:0007599 158 84 2,000 0,02133073 0,10919518 ! regulation of ligase activity GO:0051340 142 84 2,000 0,02133073 0,10896334 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,02199972 0,11214264 GO:0002696|positive regulation of leukocyte activation, ! DNA damage checkpoint GO:0000077 71 33 1,000 0,02236761 0,11377691 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,02236761 0,11353688 ! formation of primary germ layer GO:0001704 72 33 1,000 0,02236761 0,11329785 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 1,000 0,02365756 0,11958002 ! glial cell differentiation GO:0010001 63 34 1,000 0,02365756 0,11932933 ! mesoderm morphogenesis GO:0048332 76 34 1,000 0,02365756 0,11907968 ! placenta development GO:0001890 53 34 1,000 0,02365756 0,11883108 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 1,000 0,02365756 0,11858352 ! regulation of DNA binding GO:0051101 155 88 2,000 0,02407494 0,12042475 ! gland development GO:0048732 206 88 2,000 0,02407494 0,12017491 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,02497736 0,12442139 ! negative regulation of DNA metabolic process GO:0051053 61 35 1,000 0,02497736 0,12416432 ! regulation of synaptic plasticity GO:0048167 64 35 1,000 0,02497736 0,12390831 ! embryonic skeletal system morphogenesis GO:0048704 59 35 1,000 0,02497736 0,12365336 ! neutral lipid metabolic process GO:0006638 50 35 1,000 0,02497736 0,12339945 GO:0006639|acylglycerol metabolic process, ! negative regulation of hydrolase activity GO:0051346 62 35 1,000 0,02497736 0,12314658 ! ossification GO:0001503 188 90 2,000 0,02551526 0,12554136 ! regulation of cell cycle process GO:0010564 149 90 2,000 0,02551526 0,12528515 ! bone development GO:0060348 189 91 2,000 0,02625246 0,12864241 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 1,000 0,02632654 0,12874321 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of JAK-STAT cascade GO:0046427 50 36 1,000 0,02632654 0,12848207 ! DNA integrity checkpoint GO:0031570 75 36 1,000 0,02632654 0,12822198 ! androgen receptor signaling pathway GO:0030521 74 36 1,000 0,02632654 0,12796295 ! nucleosome organization GO:0034728 138 92 2,000 0,027001 0,13097664 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 1,000 0,02770463 0,13411938 ! actomyosin structure organization GO:0031032 62 37 1,000 0,02770463 0,13385007 ! tissue remodeling GO:0048771 76 37 1,000 0,02770463 0,13358183 ! monovalent inorganic cation homeostasis GO:0055067 58 37 1,000 0,02770463 0,13331467 ! negative regulation of DNA binding GO:0043392 68 37 1,000 0,02770463 0,13304857 ! glycerol ether metabolic process GO:0006662 53 37 1,000 0,02770463 0,13278353 ! positive regulation of DNA metabolic process GO:0051054 72 38 1,000 0,02911115 0,13924738 ! carbohydrate homeostasis GO:0033500 53 38 1,000 0,02911115 0,1389711 GO:0042593|glucose homeostasis, ! nucleotide catabolic process GO:0009166 61 38 1,000 0,02911115 0,13869591 ! leukocyte differentiation GO:0002521 202 96 2,000 0,03010837 0,14316351 ! organic ether metabolic process GO:0018904 55 39 1,000 0,03054565 0,1449563 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,03054565 0,14467096 ! segmentation GO:0035282 67 39 1,000 0,03054565 0,14438673 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,03054565 0,14410362 ! regulation of DNA metabolic process GO:0051052 178 97 2,000 0,03091343 0,14555327 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 1,000 0,03200768 0,15041108 ! negative regulation of binding GO:0051100 72 40 1,000 0,03200768 0,15011788 ! ribonucleoside metabolic process GO:0009119 55 40 1,000 0,03200768 0,14982582 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 1,000 0,03349677 0,15649169 ! gliogenesis GO:0042063 88 41 1,000 0,03349677 0,15618842 ! T cell differentiation GO:0030217 81 41 1,000 0,03349677 0,15588631 ! dorsal/ventral pattern formation GO:0009953 68 41 1,000 0,03349677 0,15558537 ! negative regulation of protein ubiquitination GO:0031397 9 5 0,000 0,0345449 0,16014455 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,0345449 0,15983658 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,0345449 0,15952979 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,0345449 0,15922418 ! neuron fate determination GO:0048664 7 5 0,000 0,0345449 0,15891973 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,0345449 0,15861645 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,0345449 0,15831433 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,0345449 0,15801335 ! polyol transport GO:0015791 12 5 0,000 0,0345449 0,15771351 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,0345449 0,15741481 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,0345449 0,15711724 ! response to superoxide GO:0000303 10 5 0,000 0,0345449 0,15682079 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,0345449 0,15652546 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,0345449 0,15623124 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,0345449 0,15593813 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,0345449 0,15564611 ! female meiosis GO:0007143 7 5 0,000 0,0345449 0,15535518 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,0345449 0,15506534 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,0345449 0,15477658 ! cobalt ion transport GO:0006824 11 5 0,000 0,0345449 0,15448889 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,0345449 0,15420227 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,0345449 0,15391671 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,0345449 0,1536322 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,0345449 0,15334875 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,0345449 0,15306634 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,0345449 0,15278497 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,0345449 0,15250463 GO:0006451|translational readthrough, ! negative regulation of cell-cell adhesion GO:0022408 12 5 0,000 0,0345449 0,15222531 ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,0345449 0,15194702 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,0345449 0,15166975 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,0345449 0,15139348 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,0345449 0,15111822 ! negative chemotaxis GO:0050919 14 5 0,000 0,0345449 0,15084396 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,0345449 0,15057069 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,0345449 0,15029841 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,0345449 0,15002711 ! behavioral response to pain GO:0048266 9 5 0,000 0,0345449 0,14975679 ! clathrin coat assembly GO:0048268 14 5 0,000 0,0345449 0,14948745 ! Notch receptor processing GO:0007220 8 5 0,000 0,0345449 0,14921907 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,0345449 0,14895165 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,0345449 0,14868519 ! micturition GO:0060073 9 5 0,000 0,0345449 0,14841968 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,0345449 0,14815512 ! copulation GO:0007620 9 5 0,000 0,0345449 0,1478915 ! glial cell fate commitment GO:0021781 13 5 0,000 0,0345449 0,14762881 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,0345449 0,14736706 ! spermidine metabolic process GO:0008216 7 5 0,000 0,0345449 0,14710623 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,0345449 0,14684633 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,0345449 0,14658734 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,0345449 0,14632926 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,0345449 0,14607209 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,0345449 0,14581583 ! grooming behavior GO:0007625 6 5 0,000 0,0345449 0,14556046 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,0345449 0,14530598 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,0345449 0,14505239 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,0345449 0,14479969 ! response to protozoan GO:0001562 10 5 0,000 0,0345449 0,14454786 ! lymph vessel development GO:0001945 10 5 0,000 0,0345449 0,14429691 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,0345449 0,14404683 ! endochondral ossification GO:0001958 16 5 0,000 0,0345449 0,14379761 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,0345449 0,14354926 ! parathyroid gland development GO:0060017 13 5 0,000 0,0345449 0,14330176 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,0345449 0,14305511 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 0,000 0,0345449 0,14280931 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,0345449 0,14256436 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,0345449 0,14232024 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,0345449 0,14207696 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,0345449 0,14183451 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,0345449 0,14159288 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,0345449 0,14135208 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,0345449 0,14111209 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,0345449 0,14087292 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,0345449 0,14063455 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,0345449 0,14039699 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 8 5 0,000 0,0345449 0,14016024 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,0345449 0,13992428 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,0345449 0,13968911 ! histidine catabolic process GO:0006548 6 5 0,000 0,0345449 0,13945473 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,0345449 0,13922114 ! valine metabolic process GO:0006573 10 5 0,000 0,0345449 0,13898833 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,0345449 0,1387563 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,0345449 0,13852504 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,0345449 0,13829454 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,0345449 0,13806482 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,0345449 0,13783586 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,0345449 0,13760765 ! polyol catabolic process GO:0046174 7 5 0,000 0,0345449 0,1373802 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,0345449 0,1371535 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,0345449 0,13692755 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,0345449 0,13670234 ! mitochondrial fission GO:0000266 8 5 0,000 0,0345449 0,13647787 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,0345449 0,13625413 ! mRNA transcription GO:0009299 9 5 0,000 0,0345449 0,13603113 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,0345449 0,13580886 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,0345449 0,13558731 ! positive regulation of filopodium assembly GO:0051491 14 5 0,000 0,0345449 0,13536648 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,0345449 0,13514638 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,0345449 0,13492698 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,0345449 0,1347083 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,0345449 0,13449033 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,0345449 0,13427305 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,0345449 0,13405649 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,0345449 0,13384061 ! forebrain neuron development GO:0021884 13 5 0,000 0,0345449 0,13362544 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,0345449 0,13341095 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,0345449 0,13319715 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,0345449 0,13298403 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,0345449 0,1327716 ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,0345449 0,13255984 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,0345449 0,13234876 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,0345449 0,13213835 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,0345449 0,1319286 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,0345449 0,13171953 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,0345449 0,13151111 ! basic amino acid transport GO:0015802 11 5 0,000 0,0345449 0,13130335 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,0345449 0,13109625 ! early endosome to late endosome transport GO:0045022 12 5 0,000 0,0345449 0,1308898 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,0345449 0,130684 ! depyrimidination GO:0045008 10 5 0,000 0,0345449 0,13047884 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,0345449 0,13027433 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,0345449 0,13007046 ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,0345449 0,12986722 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,0345449 0,12966462 GO:0006882|cellular zinc ion homeostasis, ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,0345449 0,12946265 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,0345449 0,12926131 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,0345449 0,12906059 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,0345449 0,1288605 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,0345449 0,12866102 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,0345449 0,12846217 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,0345449 0,12826392 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,0345449 0,12806629 ! response to arsenic GO:0046685 10 5 0,000 0,0345449 0,12786926 ! negative regulation of T cell mediated immunity GO:0002710 12 5 0,000 0,0345449 0,12767284 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,0345449 0,12747703 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,0345449 0,12728181 ! response to cadmium ion GO:0046686 7 5 0,000 0,0345449 0,12708719 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,0345449 0,12689316 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,0345449 0,12669973 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,0345449 0,12650688 ! decidualization GO:0046697 11 5 0,000 0,0345449 0,12631462 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,0345449 0,12612295 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,0345449 0,12593185 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,0345449 0,12574133 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,0345449 0,12555139 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,0345449 0,12536202 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,0345449 0,12517322 ! neural tube patterning GO:0021532 7 5 0,000 0,0345449 0,12498499 ! embryonic cleavage GO:0040016 6 5 0,000 0,0345449 0,12479733 ! peroxisome fission GO:0016559 5 5 0,000 0,0345449 0,12461023 ! histone demethylation GO:0016577 10 5 0,000 0,0345449 0,12442368 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,0345449 0,1242377 ! mitotic recombination GO:0006312 9 5 0,000 0,0345449 0,12405227 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,0345449 0,12386739 ! metaphase plate congression GO:0051310 7 5 0,000 0,0345449 0,12368307 ! regulation of sterol transport GO:0032371 7 5 0,000 0,0345449 0,12349929 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,0345449 0,12331605 ! enteric nervous system development GO:0048484 8 5 0,000 0,0345449 0,12313336 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,0345449 0,12295121 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,0345449 0,1227696 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,0345449 0,12258853 ! muscle cell proliferation GO:0033002 11 5 0,000 0,0345449 0,12240798 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,0345449 0,12222797 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 0,000 0,0345449 0,12204849 ! plasminogen activation GO:0031639 5 5 0,000 0,0345449 0,12186953 ! B cell homeostasis GO:0001782 13 5 0,000 0,0345449 0,1216911 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,0345449 0,12151319 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,0345449 0,1213358 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,0345449 0,12115892 ! cellular response to nutrient GO:0031670 8 5 0,000 0,0345449 0,12098256 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,0345449 0,12080672 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,0345449 0,12063138 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,0345449 0,12045655 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,0345449 0,12028223 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,0345449 0,12010841 ! response to redox state GO:0051775 5 5 0,000 0,0345449 0,1199351 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,0345449 0,11976228 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,0345449 0,11958996 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,0345449 0,11941813 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,0345449 0,1192468 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,0345449 0,11907596 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,0345449 0,11890561 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,0345449 0,11873574 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,0345449 0,11856636 ! striatum development GO:0021756 9 5 0,000 0,0345449 0,11839747 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 0,000 0,0345449 0,11822905 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,0345449 0,11806111 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,0345449 0,11789365 ! glial cell migration GO:0008347 11 5 0,000 0,0345449 0,11772666 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,0345449 0,11756014 ! regulation of mitochondrial depolarization GO:0051900 13 5 0,000 0,0345449 0,1173941 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,0345449 0,11722852 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,0345449 0,11706341 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,0345449 0,11689876 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,0345449 0,11673458 ! neuroprotection GO:0043526 6 5 0,000 0,0345449 0,11657086 ! neural plate development GO:0001840 8 5 0,000 0,0345449 0,11640759 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,0345449 0,11624478 ! regulation of sensory perception GO:0051931 7 5 0,000 0,0345449 0,11608243 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,0345449 0,11592053 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,0345449 0,11575908 ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,0345449 0,11559808 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,0345449 0,11543753 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,0345449 0,11527742 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,0345449 0,11511776 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,0345449 0,11495854 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,0345449 0,11479975 ! spindle assembly GO:0051225 6 5 0,000 0,0345449 0,11464141 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,0345449 0,1144835 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,0345449 0,11432603 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,0345449 0,11416898 ! drug metabolic process GO:0017144 6 5 0,000 0,0345449 0,11401237 ! phospholipid scrambling GO:0017121 8 5 0,000 0,0345449 0,11385619 ! organ regeneration GO:0031100 7 5 0,000 0,0345449 0,11370044 ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,0345449 0,11354511 ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,03501248 0,114925 GO:0090047|positive regulation of transcription regulator activity, ! regulation of intracellular protein transport GO:0033157 80 42 1,000 0,03501248 0,11476842 ! neuron migration GO:0001764 79 42 1,000 0,03501248 0,11461228 ! regulation of myeloid cell differentiation GO:0045637 98 42 1,000 0,03501248 0,11445655 ! epithelial cell differentiation GO:0030855 79 43 1,000 0,03655437 0,11933488 ! glucose transport GO:0015758 65 43 1,000 0,03655437 0,11917318 ! striated muscle cell differentiation GO:0051146 82 43 1,000 0,03655437 0,11901192 ! striated muscle contraction GO:0006941 77 43 1,000 0,03655437 0,11885109 ! hexose transport GO:0008645 67 44 1,000 0,038122 0,12378074 GO:0015749|monosaccharide transport, ! male sex differentiation GO:0046661 76 44 1,000 0,038122 0,12361392 ! double-strand break repair GO:0006302 81 44 1,000 0,038122 0,12344755 ! B cell differentiation GO:0030183 107 44 1,000 0,038122 0,12328162 ! JAK-STAT cascade GO:0007259 71 44 1,000 0,038122 0,12311615 ! developmental growth GO:0048589 82 44 1,000 0,038122 0,12295111 ! regulation of actin filament polymerization GO:0030833 87 45 1,000 0,03971494 0,12791719 ! regulation of JAK-STAT cascade GO:0046425 70 45 1,000 0,03971494 0,12774618 ! polysaccharide biosynthetic process GO:0000271 70 45 1,000 0,03971494 0,12757562 ! cell growth GO:0016049 84 45 1,000 0,03971494 0,12740552 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04131001 0,13234604 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04131001 0,13217005 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,04131001 0,13199453 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04131001 0,13181947 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04131001 0,13164487 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,04131001 0,13147074 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,04131001 0,13129707 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04131001 0,13112385 ! sleep GO:0030431 13 6 0,000 0,04131001 0,13095109 ! response to oxygen radical GO:0000305 11 6 0,000 0,04131001 0,13077879 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,04131001 0,13060694 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,04131001 0,13043554 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,04131001 0,13026459 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,04131001 0,13009408 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04131001 0,12992402 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,04131001 0,12975441 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,04131001 0,12958524 ! forebrain regionalization GO:0021871 8 6 0,000 0,04131001 0,12941651 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,04131001 0,12924822 ! male meiosis GO:0007140 7 6 0,000 0,04131001 0,12908036 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04131001 0,12891294 ! response to zinc ion GO:0010043 9 6 0,000 0,04131001 0,12874596 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04131001 0,1285794 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,04131001 0,12841328 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,04131001 0,12824759 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04131001 0,12808232 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04131001 0,12791748 ! malate metabolic process GO:0006108 11 6 0,000 0,04131001 0,12775306 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,04131001 0,12758906 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,04131001 0,12742549 ! protein refolding GO:0042026 15 6 0,000 0,04131001 0,12726233 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,04131001 0,12709959 ! opsonization GO:0008228 8 6 0,000 0,04131001 0,12693726 ! mating behavior GO:0007617 7 6 0,000 0,04131001 0,12677536 ! neuron remodeling GO:0016322 15 6 0,000 0,04131001 0,12661386 ! erythrocyte maturation GO:0043249 7 6 0,000 0,04131001 0,12645277 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,04131001 0,12629209 ! equilibrioception GO:0050957 14 6 0,000 0,04131001 0,12613183 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,04131001 0,12597196 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,04131001 0,1258125 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04131001 0,12565345 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,04131001 0,1254948 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04131001 0,12533654 ! response to interferon-gamma GO:0034341 15 6 0,000 0,04131001 0,12517869 ! toxin metabolic process GO:0009404 11 6 0,000 0,04131001 0,12502123 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04131001 0,12486417 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04131001 0,1247075 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,04131001 0,12455123 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,04131001 0,12439534 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,04131001 0,12423985 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,04131001 0,12408474 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,04131001 0,12393002 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,04131001 0,12377569 ! thymic T cell selection GO:0045061 12 6 0,000 0,04131001 0,12362174 ! protein lipoylation GO:0009249 10 6 0,000 0,04131001 0,12346817 ! cysteine metabolic process GO:0006534 10 6 0,000 0,04131001 0,12331499 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,04131001 0,12316218 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04131001 0,12300975 ! glutamate catabolic process GO:0006538 10 6 0,000 0,04131001 0,1228577 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,04131001 0,12270602 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! adenohypophysis development GO:0021984 10 6 0,000 0,04131001 0,12255472 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,04131001 0,12240379 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04131001 0,12225323 ! hyperosmotic response GO:0006972 9 6 0,000 0,04131001 0,12210304 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,04131001 0,12195323 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,04131001 0,12180377 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,04131001 0,12165469 ! urea metabolic process GO:0019627 7 6 0,000 0,04131001 0,12150596 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04131001 0,1213576 ! neutrophil activation GO:0042119 8 6 0,000 0,04131001 0,12120961 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,04131001 0,12106197 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,04131001 0,12091469 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04131001 0,12076777 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04131001 0,12062121 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04131001 0,120475 ! neuron apoptosis GO:0051402 9 6 0,000 0,04131001 0,12032915 ! nucleoside salvage GO:0043174 9 6 0,000 0,04131001 0,12018365 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,04131001 0,1200385 ! T cell mediated immunity GO:0002456 16 6 0,000 0,04131001 0,1198937 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04131001 0,11974925 GO:0010543|regulation of platelet activation, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,04131001 0,11960515 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04131001 0,11946139 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,04131001 0,11931798 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,04131001 0,11917491 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,04131001 0,11903219 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04131001 0,11888981 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,04131001 0,11874776 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,04131001 0,11860606 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,04131001 0,11846469 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,04131001 0,11832366 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,04131001 0,11818297 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 11 6 0,000 0,04131001 0,11804261 ! astrocyte development GO:0014002 15 6 0,000 0,04131001 0,11790258 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,04131001 0,11776289 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04131001 0,11762352 ! interaction with symbiont GO:0051702 13 6 0,000 0,04131001 0,11748449 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04131001 0,11734578 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04131001 0,1172074 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,04131001 0,11706935 ! response to copper ion GO:0046688 10 6 0,000 0,04131001 0,11693162 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,04131001 0,11679422 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,04131001 0,11665713 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04131001 0,11652037 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04131001 0,11638393 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,04131001 0,11624781 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04131001 0,11611201 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04131001 0,11597652 ! Schwann cell development GO:0014044 15 6 0,000 0,04131001 0,11584135 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,04131001 0,11570649 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04131001 0,11557195 ! regulation of myeloid cell apoptosis GO:0033032 13 6 0,000 0,04131001 0,11543772 ! subpallium development GO:0021544 10 6 0,000 0,04131001 0,1153038 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,04131001 0,1151702 ! histone ubiquitination GO:0016574 8 6 0,000 0,04131001 0,1150369 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,04131001 0,11490391 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04131001 0,11477122 ! G2 phase GO:0051319 16 6 0,000 0,04131001 0,11463884 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,04131001 0,11450677 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04131001 0,114375 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,04131001 0,11424354 ! membrane to membrane docking GO:0022614 14 6 0,000 0,04131001 0,11411237 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04131001 0,11398151 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,04131001 0,11385095 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04131001 0,11372068 ! receptor internalization GO:0031623 10 6 0,000 0,04131001 0,11359072 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,04131001 0,11346105 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,04131001 0,11333167 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04131001 0,1132026 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,04131001 0,11307381 ! protein deubiquitination GO:0016579 14 6 0,000 0,04131001 0,11294532 ! protein destabilization GO:0031648 9 6 0,000 0,04131001 0,11281712 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04131001 0,1126892 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,04131001 0,11256158 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04131001 0,11243425 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,04131001 0,11230721 ! progesterone metabolic process GO:0042448 10 6 0,000 0,04131001 0,11218045 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,04131001 0,11205398 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,04131001 0,11192779 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,04131001 0,11180189 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,04131001 0,11167627 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,04131001 0,11155093 ! determination of adult lifespan GO:0008340 15 6 0,000 0,04131001 0,11142587 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,04131001 0,1113011 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,04131001 0,1111766 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04131001 0,11105238 ! catecholamine transport GO:0051937 9 6 0,000 0,04131001 0,11092844 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,04131001 0,11080477 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04131001 0,11068138 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04131001 0,11055826 ! maternal placenta development GO:0001893 12 6 0,000 0,04131001 0,11043542 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,04131001 0,11031285 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04131001 0,11019055 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,04131001 0,11006853 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04131001 0,10994677 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,04131001 0,10982528 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,04131001 0,10970406 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 1,000 0,04133276 0,10964346 ! positive regulation of protein transport GO:0051222 72 46 1,000 0,04133276 0,1095227 ! endosome transport GO:0016197 108 47 1,000 0,04297503 0,1137491 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,04297503 0,1136241 ! mitochondrial transport GO:0006839 82 48 1,000 0,04464135 0,11790021 ! regulation of action potential GO:0001508 95 49 1,000 0,04633129 0,12222926 ! peptide metabolic process GO:0006518 76 49 1,000 0,04633129 0,12209539 ! response to temperature stimulus GO:0009266 76 49 1,000 0,04633129 0,1219618 ! tRNA transcription GO:0009304 14 7 0,000 0,04802794 0,12628986 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,04802794 0,12615198 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,04802794 0,12601441 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04802794 0,12587714 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,04802794 0,12574017 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,04802794 0,1256035 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,04802794 0,12546712 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04802794 0,12533104 ! prostate gland development GO:0030850 13 7 0,000 0,04802794 0,12519525 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,04802794 0,12505976 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04802794 0,12492456 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04802794 0,12478965 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,04802794 0,12465504 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04802794 0,12452071 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,04802794 0,12438667 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,04802794 0,12425292 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,04802794 0,12411946 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,04802794 0,12398629 ! glycolipid transport GO:0046836 10 7 0,000 0,04802794 0,1238534 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04802794 0,12372079 GO:0051923|sulfation, ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04802794 0,12358847 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,04802794 0,12345643 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04802794 0,12332467 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,04802794 0,1231932 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,04802794 0,123062 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,04802794 0,12293108 ! mRNA stabilization GO:0048255 18 7 0,000 0,04802794 0,12280044 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 14 7 0,000 0,04802794 0,12267008 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,04802794 0,12254 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,04802794 0,12241019 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,04802794 0,12228065 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04802794 0,12215139 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,04802794 0,12202241 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04802794 0,12189369 ! lipoprotein transport GO:0042953 14 7 0,000 0,04802794 0,12176525 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04802794 0,12163707 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04802794 0,12150917 ! rhythmic behavior GO:0007622 15 7 0,000 0,04802794 0,12138153 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,04802794 0,12125416 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,04802794 0,12112706 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,04802794 0,12100023 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04802794 0,12087366 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,04802794 0,12074735 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04802794 0,12062131 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,04802794 0,12049553 ! mechanosensory behavior GO:0007638 14 7 0,000 0,04802794 0,12037002 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04802794 0,12024476 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 0,000 0,04802794 0,12011977 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04802794 0,11999503 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04802794 0,11987056 ! spinal cord patterning GO:0021511 13 7 0,000 0,04802794 0,11974634 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,04802794 0,11962238 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04802794 0,11949867 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,04802794 0,11937523 ! adrenal gland development GO:0030325 17 7 0,000 0,04802794 0,11925203 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,04802794 0,11912909 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,04802794 0,1190064 ! ovulation GO:0030728 9 7 0,000 0,04802794 0,11888397 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,04802794 0,11876179 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,04802794 0,11863985 ! microtubule nucleation GO:0007020 20 7 0,000 0,04802794 0,11851817 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04802794 0,11839674 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04802794 0,11827556 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,04802794 0,11815462 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,04802794 0,11803393 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,04802794 0,11791349 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04802794 0,11779329 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04802794 0,11767334 ! galactose metabolic process GO:0006012 13 7 0,000 0,04802794 0,11755363 ! vesicle fusion GO:0006906 17 7 0,000 0,04802794 0,11743416 ! response to dietary excess GO:0002021 8 7 0,000 0,04802794 0,11731494 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04802794 0,11719596 ! intracellular pH reduction GO:0051452 11 7 0,000 0,04802794 0,11707722 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04802794 0,11695872 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,04802794 0,11684046 ! organ growth GO:0035265 15 7 0,000 0,04802794 0,11672244 ! purine salvage GO:0043101 10 7 0,000 0,04802794 0,11660466 ! nucleoside transport GO:0015858 8 7 0,000 0,04802794 0,11648711 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,04802794 0,11636981 ! parturition GO:0007567 14 7 0,000 0,04802794 0,11625273 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,04802794 0,1161359 ! rRNA modification GO:0000154 14 7 0,000 0,04802794 0,1160193 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,04802794 0,11590293 ! spindle checkpoint GO:0031577 15 7 0,000 0,04802794 0,11578679 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,04802794 0,11567089 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,04802794 0,11555522 ! macrophage differentiation GO:0030225 11 7 0,000 0,04802794 0,11543978 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04802794 0,11532457 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04802794 0,11520959 GO:0046676|negative regulation of insulin secretion, ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,04802794 0,11509484 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04802794 0,11498032 ! eating behavior GO:0042755 7 7 0,000 0,04802794 0,11486602 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04802794 0,11475195 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,04802794 0,11463811 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,04802794 0,1145245 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04802794 0,11441111 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04802794 0,11429794 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,04802794 0,114185 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,04802794 0,11407228 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,04802794 0,11395978 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04802794 0,11384751 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,04802794 0,11373545 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04802794 0,11362362 ! regulation of meiosis GO:0040020 12 7 0,000 0,04802794 0,113512 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,04802794 0,11340061 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 0,000 0,04802794 0,11328943 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,04802794 0,11317847 ! oxygen homeostasis GO:0032364 12 7 0,000 0,04802794 0,11306773 ! transcription termination GO:0006353 13 7 0,000 0,04802794 0,1129572 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04802794 0,11284689 ! anaphase GO:0051322 17 7 0,000 0,04802794 0,1127368 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,04802794 0,11262692 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,04802794 0,11251725 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,04802794 0,1124078 ! peptidyl-threonine modification GO:0018210 25 7 0,000 0,04802794 0,11229856 ! diuresis GO:0030146 12 7 0,000 0,04802794 0,11218953 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04802794 0,11208072 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04802794 0,11197211 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04802794 0,11186372 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 0,000 0,04802794 0,11175553 GO:0002688|regulation of leukocyte chemotaxis, ! antibiotic transport GO:0042891 9 7 0,000 0,04802794 0,11164755 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04802794 0,11153979 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04802794 0,11143223 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04802794 0,11132487 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04802794 0,11121773 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,04802794 0,11111079 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04802794 0,11100405 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,04802794 0,11089752 GO:0046479|glycosphingolipid catabolic process, ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,04802794 0,1107912 ! lymph node development GO:0048535 10 7 0,000 0,04802794 0,11068507 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,04802794 0,11057916 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04802794 0,11047344 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 0,000 0,04802794 0,11036793 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,04802794 0,11026261 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,04802794 0,1101575 ! adult feeding behavior GO:0008343 9 7 0,000 0,04802794 0,11005259 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,04802794 0,10994788 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,04802794 0,10984336 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04802794 0,10973905 ! muscle adaptation GO:0043500 14 7 0,000 0,04802794 0,10963493 ! embryonic heart tube development GO:0035050 10 7 0,000 0,04802794 0,10953101 ! retina homeostasis GO:0001895 12 7 0,000 0,04802794 0,10942729 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,04802794 0,10932376 ! positive regulation of smooth muscle contraction GO:0045987 10 7 0,000 0,04802794 0,10922043 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,04802794 0,1091173 ! protein prenylation GO:0018342 18 7 0,000 0,04802794 0,10901436 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,04802794 0,10891161 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,04802794 0,10880906 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04802794 0,1087067 ! regulation of ossification GO:0030278 117 50 1,000 0,04804445 0,10864187 ! histone modification GO:0016570 91 50 1,000 0,04804445 0,10853985 ! positive regulation of binding GO:0051099 78 51 1,000 0,04978042 0,11235618 ! viral infectious cycle GO:0019058 99 51 1,000 0,04978042 0,11225088 ! embryonic skeletal system development GO:0048706 85 51 1,000 0,04978042 0,11214577 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 1,000 0,04978042 0,11204086 ! regulation of cell shape GO:0008360 125 51 1,000 0,04978042 0,11193615 ! membrane fusion GO:0006944 110 52 1,000 0,0515388 0,11578183 ! covalent chromatin modification GO:0016569 101 52 1,000 0,0515388 0,11567383 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 1,000 0,05331919 0,11955822 ! regulation of protein polymerization GO:0032271 103 53 1,000 0,05331919 0,1194469 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,05469901 0,12242403 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,05469901 0,12231025 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,05469901 0,12219668 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,05469901 0,12208333 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05469901 0,12197018 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05469901 0,12185725 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,05469901 0,12174452 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,05469901 0,121632 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,05469901 0,12151969 ! meiotic prophase I GO:0007128 13 8 0,000 0,05469901 0,12140759 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05469901 0,12129569 ! oligopeptide transport GO:0006857 15 8 0,000 0,05469901 0,121184 ! UTP metabolic process GO:0046051 8 8 0,000 0,05469901 0,12107252 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,05469901 0,12096124 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,05469901 0,12085016 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,05469901 0,12073929 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,05469901 0,12062862 ! succinate metabolic process GO:0006105 14 8 0,000 0,05469901 0,12051816 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05469901 0,12040789 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,05469901 0,12029783 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,05469901 0,12018797 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,05469901 0,12007831 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,05469901 0,11996885 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05469901 0,11985959 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05469901 0,11975053 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,05469901 0,11964166 ! reflex GO:0060004 16 8 0,000 0,05469901 0,11953299 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,05469901 0,11942453 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,05469901 0,11931625 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05469901 0,11920818 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,05469901 0,1191003 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,05469901 0,11899261 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,05469901 0,11888512 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,05469901 0,11877782 ! pigment granule organization GO:0048753 16 8 0,000 0,05469901 0,11867072 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,05469901 0,11856381 ! astrocyte differentiation GO:0048708 18 8 0,000 0,05469901 0,11845709 ! histidine metabolic process GO:0006547 16 8 0,000 0,05469901 0,11835056 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05469901 0,11824423 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,05469901 0,11813809 ! glycine catabolic process GO:0006546 13 8 0,000 0,05469901 0,11803213 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,05469901 0,11792637 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,05469901 0,11782079 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,05469901 0,11771541 ! regulation of pigmentation during development GO:0048070 24 8 0,000 0,05469901 0,11761021 ! melanin metabolic process GO:0006582 15 8 0,000 0,05469901 0,1175052 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,05469901 0,11740038 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05469901 0,11729575 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,05469901 0,1171913 ! macrophage activation GO:0042116 12 8 0,000 0,05469901 0,11708703 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05469901 0,11698296 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,05469901 0,11687907 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,05469901 0,11677536 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,05469901 0,11667183 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05469901 0,11656849 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,05469901 0,11646533 ! osteoblast development GO:0002076 16 8 0,000 0,05469901 0,11636236 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,05469901 0,11625956 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,05469901 0,11615695 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,05469901 0,11605452 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,05469901 0,11595227 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,05469901 0,1158502 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05469901 0,11574831 ! response to UV-B GO:0010224 16 8 0,000 0,05469901 0,1156466 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,05469901 0,11554506 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05469901 0,11544371 ! intermediate filament organization GO:0045109 12 8 0,000 0,05469901 0,11534253 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,05469901 0,11524153 ! cellular extravasation GO:0045123 12 8 0,000 0,05469901 0,11514071 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,05469901 0,11504006 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,05469901 0,11493959 ! response to antibiotic GO:0046677 11 8 0,000 0,05469901 0,11483929 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,05469901 0,11473917 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,05469901 0,11463922 ! response to tropane GO:0014073 15 8 0,000 0,05469901 0,11453945 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,05469901 0,11443985 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,05469901 0,11434042 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05469901 0,11424117 ! mast cell activation GO:0045576 14 8 0,000 0,05469901 0,11414209 ! multicellular organismal aging GO:0010259 18 8 0,000 0,05469901 0,11404318 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,05469901 0,11394444 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,05469901 0,11384587 ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05469901 0,11374747 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,05469901 0,11364925 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05469901 0,11355119 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05469901 0,1134533 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,05469901 0,11335558 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,05469901 0,11325803 ! intracellular lipid transport GO:0032365 13 8 0,000 0,05469901 0,11316064 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05469901 0,11306343 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05469901 0,11296638 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,05469901 0,11286949 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,05469901 0,11277277 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05469901 0,11267622 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,05469901 0,11257984 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,05469901 0,11248361 ! hormone catabolic process GO:0042447 17 8 0,000 0,05469901 0,11238756 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05469901 0,11229166 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,05469901 0,11219593 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,05469901 0,11210036 ! ATP catabolic process GO:0006200 11 8 0,000 0,05469901 0,11200496 ! blastocyst growth GO:0001832 19 8 0,000 0,05469901 0,11190972 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,05469901 0,11181464 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05469901 0,11171972 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,05469901 0,11162496 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05469901 0,11153036 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05469901 0,11143592 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,05469901 0,11134165 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,05469901 0,11124753 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,05469901 0,11115357 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,05469901 0,11105977 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,05469901 0,11096613 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 16 8 0,000 0,05469901 0,11087264 ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05469901 0,11077932 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 0,000 0,05469901 0,11068615 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05469901 0,11059313 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05469901 0,11050027 GO:0000076|DNA replication checkpoint, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,05469901 0,11040757 ! NAD biosynthetic process GO:0009435 13 8 0,000 0,05469901 0,11031503 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,05512121 0,11107339 GO:0010863|positive regulation of phospholipase C activity, ! cell recognition GO:0008037 85 54 1,000 0,05512121 0,11098044 ! heterocycle catabolic process GO:0046700 85 54 1,000 0,05512121 0,11088764 ! chloride transport GO:0006821 90 55 1,000 0,05694446 0,11445979 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,05694446 0,11436425 ! gastrulation GO:0007369 112 55 1,000 0,05694446 0,11426886 ! heart morphogenesis GO:0003007 97 55 1,000 0,05694446 0,11417364 ! regulation of multicellular organism growth GO:0040014 85 55 1,000 0,05694446 0,11407857 ! regulation of actin filament length GO:0030832 105 56 1,000 0,05878857 0,11767495 ! nucleotide-excision repair GO:0006289 83 56 1,000 0,05878857 0,11757713 ! positive regulation of organelle organization GO:0010638 100 56 1,000 0,05878857 0,11747948 ! regulation of bone remodeling GO:0046850 137 57 1,000 0,06065315 0,12110496 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,06065315 0,12100454 ! regulation of intracellular transport GO:0032386 101 57 1,000 0,06065315 0,12090428 ! maintenance of location GO:0051235 118 57 1,000 0,06065315 0,1208042 ! axon extension GO:0048675 15 9 0,000 0,06132356 0,12203845 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,06132356 0,12193759 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,06132356 0,1218369 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,06132356 0,12173638 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06132356 0,12163602 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,06132356 0,12153582 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,06132356 0,12143579 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,06132356 0,12133593 ! phosphate transport GO:0006817 19 9 0,000 0,06132356 0,12123623 ! reproductive behavior GO:0019098 19 9 0,000 0,06132356 0,12113669 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06132356 0,12103732 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,06132356 0,12093811 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06132356 0,12083906 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,06132356 0,12074017 ! GTP metabolic process GO:0046039 9 9 0,000 0,06132356 0,12064145 ! RNA methylation GO:0001510 15 9 0,000 0,06132356 0,12054288 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,06132356 0,12044448 ! artery development GO:0060840 24 9 0,000 0,06132356 0,12034624 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,06132356 0,12024816 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,06132356 0,12015024 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,06132356 0,12005247 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 0,000 0,06132356 0,11995487 ! chemosensory behavior GO:0007635 20 9 0,000 0,06132356 0,11985742 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,06132356 0,11976014 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,06132356 0,11966301 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06132356 0,11956604 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,06132356 0,11946922 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,06132356 0,11937256 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06132356 0,11927606 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06132356 0,11917972 ! protein targeting to ER GO:0045047 22 9 0,000 0,06132356 0,11908353 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,06132356 0,11898749 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,06132356 0,11889161 ! T cell selection GO:0045058 23 9 0,000 0,06132356 0,11879588 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,06132356 0,11870031 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06132356 0,11860489 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,06132356 0,11850963 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06132356 0,11841452 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06132356 0,11831956 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06132356 0,11822475 ! mannose metabolic process GO:0006013 13 9 0,000 0,06132356 0,1181301 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,06132356 0,11803559 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,06132356 0,11794124 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,06132356 0,11784704 ! receptor clustering GO:0043113 18 9 0,000 0,06132356 0,11775298 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,06132356 0,11765908 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06132356 0,11756533 ! ruffle organization GO:0031529 15 9 0,000 0,06132356 0,11747173 ! retinol metabolic process GO:0042572 18 9 0,000 0,06132356 0,11737827 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,06132356 0,11728497 ! behavioral fear response GO:0001662 22 9 0,000 0,06132356 0,11719181 GO:0002209|behavioral defense response, ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,06132356 0,1170988 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,06132356 0,11700594 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,06132356 0,11691322 GO:0030204|chondroitin sulfate metabolic process, ! oligodendrocyte development GO:0014003 10 9 0,000 0,06132356 0,11682066 ! alpha-beta T cell differentiation GO:0046632 21 9 0,000 0,06132356 0,11672824 ! segment specification GO:0007379 13 9 0,000 0,06132356 0,11663596 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06132356 0,11654383 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,06132356 0,11645185 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06132356 0,11636001 ! response to amine stimulus GO:0014075 13 9 0,000 0,06132356 0,11626831 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06132356 0,11617676 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,06132356 0,11608536 ! erythrocyte development GO:0048821 15 9 0,000 0,06132356 0,1159941 ! gas homeostasis GO:0033483 16 9 0,000 0,06132356 0,11590298 ! regulation of mitochondrial membrane potential GO:0051881 17 9 0,000 0,06132356 0,115812 ! renal water homeostasis GO:0003091 14 9 0,000 0,06132356 0,11572117 ! postreplication repair GO:0006301 22 9 0,000 0,06132356 0,11563048 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,06132356 0,11553993 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,06132356 0,11544952 ! icosanoid secretion GO:0032309 15 9 0,000 0,06132356 0,11535926 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06132356 0,11526913 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,06132356 0,11517915 ! regulation of cell division GO:0051302 15 9 0,000 0,06132356 0,11508931 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,06132356 0,1149996 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,06132356 0,11491004 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06132356 0,11482061 ! sterol catabolic process GO:0016127 11 9 0,000 0,06132356 0,11473133 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06132356 0,11464218 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,06132356 0,11455317 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 0,000 0,06132356 0,11446431 GO:0002820|negative regulation of adaptive immune response, ! S phase GO:0051320 9 9 0,000 0,06132356 0,11437557 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,06132356 0,11428698 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,06132356 0,11419852 ! musculoskeletal movement GO:0050881 14 9 0,000 0,06132356 0,1141102 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,06132356 0,11402202 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,06132356 0,11393397 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,06132356 0,11384606 ! purine base metabolic process GO:0006144 21 9 0,000 0,06132356 0,11375828 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,06132356 0,11367064 ! pigment granule transport GO:0051904 17 9 0,000 0,06132356 0,11358313 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,06132356 0,11349576 ! regulation of telomere maintenance GO:0032204 14 9 0,000 0,06132356 0,11340852 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,06132356 0,11332142 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,06132356 0,11323445 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06132356 0,11314761 ! mitochondrion localization GO:0051646 15 9 0,000 0,06132356 0,11306091 ! regulation of tissue remodeling GO:0034103 140 58 1,000 0,06253783 0,11521134 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,06253783 0,11512319 ! regulation of cellular component size GO:0032535 109 59 1,000 0,06444224 0,11853825 ! skeletal system morphogenesis GO:0048705 105 59 1,000 0,06444224 0,11844769 ! cytokine-mediated signaling pathway GO:0019221 97 59 1,000 0,06444224 0,11835728 ! DNA catabolic process GO:0006308 86 59 1,000 0,06444224 0,118267 ! DNA damage response, signal transduction GO:0042770 128 60 1,000 0,06636602 0,12170476 ! nucleoside metabolic process GO:0009116 81 60 1,000 0,06636602 0,12161206 ! camera-type eye development GO:0043010 116 60 1,000 0,06636602 0,12151951 ! kidney development GO:0001822 122 60 1,000 0,06636602 0,1214271 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,0679019 0,12414284 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,0679019 0,12404858 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,0679019 0,12395446 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,0679019 0,12386049 ! synapsis GO:0007129 13 10 0,000 0,0679019 0,12376665 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,0679019 0,12367296 ! N-glycan processing GO:0006491 20 10 0,000 0,0679019 0,12357941 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,0679019 0,123486 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,0679019 0,12339273 ! social behavior GO:0035176 24 10 0,000 0,0679019 0,12329961 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,0679019 0,12320662 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,0679019 0,12311378 ! androgen metabolic process GO:0008209 17 10 0,000 0,0679019 0,12302107 ! phospholipid efflux GO:0033700 16 10 0,000 0,0679019 0,1229285 ! positive regulation of heart contraction GO:0045823 16 10 0,000 0,0679019 0,12283608 ! lung alveolus development GO:0048286 26 10 0,000 0,0679019 0,12274379 ! pathogenesis GO:0009405 13 10 0,000 0,0679019 0,12265164 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,0679019 0,12255963 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,0679019 0,12246775 ! negative regulation of striated muscle development GO:0045843 19 10 0,000 0,0679019 0,12237602 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,0679019 0,12228442 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,0679019 0,12219295 ! endoderm development GO:0007492 16 10 0,000 0,0679019 0,12210163 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,0679019 0,12201044 ! arginine catabolic process GO:0006527 13 10 0,000 0,0679019 0,12191939 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,0679019 0,12182847 ! proline metabolic process GO:0006560 13 10 0,000 0,0679019 0,12173769 ! L-serine metabolic process GO:0006563 18 10 0,000 0,0679019 0,12164704 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,0679019 0,12155653 ! V(D)J recombination GO:0033151 28 10 0,000 0,0679019 0,12146616 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,0679019 0,12137591 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,0679019 0,12128581 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,0679019 0,12119583 ! B cell proliferation GO:0042100 18 10 0,000 0,0679019 0,12110599 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,0679019 0,12101628 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,0679019 0,12092671 ! multicellular organism growth GO:0035264 18 10 0,000 0,0679019 0,12083726 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,0679019 0,12074795 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,0679019 0,12065877 ! epithelial cell development GO:0002064 20 10 0,000 0,0679019 0,12056973 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,0679019 0,12048081 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,0679019 0,12039203 ! macroautophagy GO:0016236 17 10 0,000 0,0679019 0,12030337 ! positive regulation of muscle contraction GO:0045933 14 10 0,000 0,0679019 0,12021485 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,0679019 0,12012646 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,0679019 0,12003819 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,0679019 0,11995006 ! copper ion homeostasis GO:0055070 13 10 0,000 0,0679019 0,11986205 ! regulation of bone resorption GO:0045124 25 10 0,000 0,0679019 0,11977418 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,0679019 0,11968643 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,0679019 0,11959881 ! alpha-beta T cell activation GO:0046631 23 10 0,000 0,0679019 0,11951132 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,0679019 0,11942396 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,0679019 0,11933673 ! blastoderm segmentation GO:0007350 18 10 0,000 0,0679019 0,11924962 ! response to dsRNA GO:0043331 20 10 0,000 0,0679019 0,11916264 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,0679019 0,11907579 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,0679019 0,11898906 ! melanosome localization GO:0032400 16 10 0,000 0,0679019 0,11890246 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,0679019 0,11881599 ! regulation of B cell differentiation GO:0045577 19 10 0,000 0,0679019 0,11872964 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,0679019 0,11864341 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,0679019 0,11855732 ! mRNA cleavage GO:0006379 17 10 0,000 0,0679019 0,11847134 ! protein sumoylation GO:0016925 15 10 0,000 0,0679019 0,11838549 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,0679019 0,11829977 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,0679019 0,11821417 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,0679019 0,11812869 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,0679019 0,11804334 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,0679019 0,11795811 ! salivary gland development GO:0007431 27 10 0,000 0,0679019 0,117873 ! prophase GO:0051324 15 10 0,000 0,0679019 0,11778802 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,0679019 0,11770316 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,0679019 0,11761842 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,0679019 0,1175338 ! positive regulation of leukocyte migration GO:0002687 25 10 0,000 0,0679019 0,1174493 ! midbrain development GO:0030901 13 10 0,000 0,0679019 0,11736493 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,0679019 0,11728068 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,0679019 0,11719654 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,0679019 0,11711253 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,0679019 0,11702864 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,0679019 0,11694487 ! detection of calcium ion GO:0005513 23 10 0,000 0,0679019 0,11686122 ! oocyte development GO:0048599 17 10 0,000 0,0679019 0,11677768 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,0679019 0,11669427 ! blastocyst formation GO:0001825 17 10 0,000 0,0679019 0,11661098 ! cerebellar cortex development GO:0021695 15 10 0,000 0,0679019 0,1165278 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,0679019 0,11644475 ! activation of innate immune response GO:0002218 12 10 0,000 0,0679019 0,11636181 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,0679019 0,11627899 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,0679019 0,11619629 ! response to nicotine GO:0035094 20 10 0,000 0,0679019 0,1161137 ! negative regulation of immune effector process GO:0002698 20 10 0,000 0,0679019 0,11603124 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,0679019 0,11594889 ! regulation of protein complex assembly GO:0043254 117 61 1,000 0,0683088 0,11656097 ! water-soluble vitamin metabolic process GO:0006767 95 62 1,000 0,07027022 0,11982293 ! gonad development GO:0008406 98 62 1,000 0,07027022 0,11973807 ! regulation of mitosis GO:0007088 105 63 1,000 0,07224994 0,12302431 GO:0051783|regulation of nuclear division, ! regulation of lipid metabolic process GO:0019216 115 63 1,000 0,07224994 0,12293731 ! steroid hormone receptor signaling pathway GO:0030518 129 63 1,000 0,07224994 0,12285043 ! negative regulation of muscle development GO:0048635 20 11 0,000 0,07443436 0,12647533 ! respiratory burst GO:0045730 17 11 0,000 0,07443436 0,12638608 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,07443436 0,12629695 ! neuron fate specification GO:0048665 17 11 0,000 0,07443436 0,12620794 ! telencephalon cell migration GO:0022029 20 11 0,000 0,07443436 0,12611907 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,07443436 0,12603031 GO:0046579|positive regulation of Ras protein signal transduction, ! thyroid gland development GO:0030878 26 11 0,000 0,07443436 0,12594168 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,07443436 0,12585318 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,07443436 0,1257648 ! response to pain GO:0048265 24 11 0,000 0,07443436 0,12567654 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,07443436 0,12558841 ! T cell proliferation GO:0042098 26 11 0,000 0,07443436 0,1255004 ! blood vessel remodeling GO:0001974 29 11 0,000 0,07443436 0,12541252 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 0,000 0,07443436 0,12532475 ! bone resorption GO:0045453 16 11 0,000 0,07443436 0,12523711 ! ventral spinal cord development GO:0021517 21 11 0,000 0,07443436 0,1251496 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,07443436 0,1250622 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,07443436 0,12497493 ! melanocyte differentiation GO:0030318 21 11 0,000 0,07443436 0,12488778 GO:0050931|pigment cell differentiation, ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,07443436 0,12480075 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,07443436 0,12471384 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,07443436 0,12462705 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 18 11 0,000 0,07443436 0,12454038 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,07443436 0,12445384 ! UV protection GO:0009650 19 11 0,000 0,07443436 0,12436741 ! adult heart development GO:0007512 14 11 0,000 0,07443436 0,12428111 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,07443436 0,12419492 ! temperature homeostasis GO:0001659 17 11 0,000 0,07443436 0,12410885 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,07443436 0,1240229 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,07443436 0,12393708 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,07443436 0,12385136 ! regulation of organ growth GO:0046620 13 11 0,000 0,07443436 0,12376577 ! pigment granule localization GO:0051875 20 11 0,000 0,07443436 0,1236803 ! positive regulation of T cell mediated immunity GO:0002711 24 11 0,000 0,07443436 0,12359494 ! vasoconstriction GO:0042310 18 11 0,000 0,07443436 0,12350971 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,07443436 0,12342459 ! embryonic axis specification GO:0000578 18 11 0,000 0,07443436 0,12333958 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,07443436 0,1232547 ! snRNA metabolic process GO:0016073 24 11 0,000 0,07443436 0,12316993 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,07443436 0,12308527 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,07443436 0,12300074 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,07443436 0,12291632 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,07443436 0,12283201 ! zymogen activation GO:0031638 15 11 0,000 0,07443436 0,12274782 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,07443436 0,12266375 ! neuroblast proliferation GO:0007405 24 11 0,000 0,07443436 0,12257979 ! nucleosome positioning GO:0016584 15 11 0,000 0,07443436 0,12249595 ! regulation of isotype switching GO:0045191 22 11 0,000 0,07443436 0,12241222 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,07443436 0,1223286 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,07443436 0,1222451 ! regulation of leukocyte migration GO:0002685 26 11 0,000 0,07443436 0,12216171 ! acid secretion GO:0046717 18 11 0,000 0,07443436 0,12207844 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,07443436 0,12199528 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,07443436 0,12191224 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,07443436 0,1218293 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,07443436 0,12174648 ! oocyte differentiation GO:0009994 18 11 0,000 0,07443436 0,12166377 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,07443436 0,12158118 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 27 11 0,000 0,07443436 0,12149869 ! cholesterol efflux GO:0033344 19 11 0,000 0,07443436 0,12141632 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,07443436 0,12133406 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,07443436 0,12125191 ! germ cell migration GO:0008354 25 11 0,000 0,07443436 0,12116987 ! embryonic gut development GO:0048566 15 11 0,000 0,07443436 0,12108795 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,07443436 0,12100613 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,07443436 0,12092442 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,07443436 0,12084283 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,07443436 0,12076134 ! defense response to fungus GO:0050832 13 11 0,000 0,07443436 0,12067997 ! lysogeny GO:0030069 21 11 0,000 0,07443436 0,1205987 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,07443436 0,12051755 ! T cell receptor signaling pathway GO:0050852 23 11 0,000 0,07443436 0,1204365 ! sequestering of metal ion GO:0051238 14 11 0,000 0,07443436 0,12035556 ! lamellipodium assembly GO:0030032 20 11 0,000 0,07443436 0,12027473 ! nucleus localization GO:0051647 19 11 0,000 0,07443436 0,12019401 ! regulation of synapse organization GO:0050807 17 11 0,000 0,07443436 0,1201134 ! myeloid cell differentiation GO:0030099 111 65 1,000 0,07626285 0,12298151 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 1,000 0,07829536 0,12617457 ! actin filament organization GO:0007015 148 66 1,000 0,07829536 0,12609011 ! developmental maturation GO:0021700 116 66 1,000 0,07829536 0,12600577 ! activation of MAPK activity GO:0000187 115 67 1,000 0,08034478 0,12921761 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,08034478 0,12913129 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,08034478 0,12904509 ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,08092125 0,12988428 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,08092125 0,12979769 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,08092125 0,12971122 ! cartilage condensation GO:0001502 20 12 0,000 0,08092125 0,12962486 ! mating GO:0007618 17 12 0,000 0,08092125 0,12953861 ! protein complex disassembly GO:0043241 27 12 0,000 0,08092125 0,12945248 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,08092125 0,12936647 ! regulation of cell projection assembly GO:0060491 30 12 0,000 0,08092125 0,12928057 ! hippocampus development GO:0021766 26 12 0,000 0,08092125 0,12919478 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 0,000 0,08092125 0,12910911 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,08092125 0,12902355 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08092125 0,1289381 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,08092125 0,12885277 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,08092125 0,12876755 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,08092125 0,12868244 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,08092125 0,12859745 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,08092125 0,12851256 ! drug transport GO:0015893 16 12 0,000 0,08092125 0,12842779 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,08092125 0,12834313 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,08092125 0,12825859 ! polyamine metabolic process GO:0006595 17 12 0,000 0,08092125 0,12817415 ! focal adhesion formation GO:0048041 35 12 0,000 0,08092125 0,12808982 ! mitotic spindle organization GO:0007052 21 12 0,000 0,08092125 0,12800561 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,08092125 0,12792151 ! forebrain cell migration GO:0021885 21 12 0,000 0,08092125 0,12783751 ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,08092125 0,12775363 ! entry into host cell GO:0030260 32 12 0,000 0,08092125 0,12766986 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 26 12 0,000 0,08092125 0,1275862 ! monoamine transport GO:0015844 18 12 0,000 0,08092125 0,12750264 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08092125 0,1274192 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,08092125 0,12733586 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,08092125 0,12725264 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,08092125 0,12716952 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08092125 0,12708651 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,08092125 0,12700361 ! protein homotetramerization GO:0051289 21 12 0,000 0,08092125 0,12692082 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,08092125 0,12683813 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,08092125 0,12675556 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08092125 0,12667309 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,08092125 0,12659072 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,08092125 0,12650847 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08092125 0,12642632 ! fucose catabolic process GO:0019317 22 12 0,000 0,08092125 0,12634428 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,08092125 0,12626234 ! histone methylation GO:0016571 26 12 0,000 0,08092125 0,12618051 ! gland morphogenesis GO:0022612 29 12 0,000 0,08092125 0,12609879 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,08092125 0,12601717 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,08092125 0,12593566 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,08092125 0,12585426 ! spleen development GO:0048536 22 12 0,000 0,08092125 0,12577295 ! digestive tract morphogenesis GO:0048546 26 12 0,000 0,08092125 0,12569176 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,08092125 0,12561067 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,08092125 0,12552968 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,08092125 0,1254488 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,08092125 0,12536802 ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 0,000 0,08092125 0,12528734 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,08092125 0,12520677 ! response to cold GO:0009409 17 12 0,000 0,08092125 0,12512631 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,08092125 0,12504594 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,08092125 0,12496568 ! amino acid transport GO:0006865 125 68 1,000 0,08241079 0,12718432 ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,08241079 0,12710279 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 1,000 0,08241079 0,12702137 ! regulation of lipase activity GO:0060191 130 68 1,000 0,08241079 0,12694005 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 1,000 0,08241079 0,12685883 ! cAMP-mediated signaling GO:0019933 120 69 1,000 0,08449304 0,12998099 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 1,000 0,08449304 0,12989793 ! urogenital system development GO:0001655 137 69 1,000 0,08449304 0,12981498 ! cGMP metabolic process GO:0046068 18 13 0,000 0,08736289 0,13413856 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,08736289 0,13405301 ! regulation of chemokine production GO:0032642 18 13 0,000 0,08736289 0,13396757 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,08736289 0,13388224 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,08736289 0,13379702 ! regulation of cell-cell adhesion GO:0022407 33 13 0,000 0,08736289 0,13371191 ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 0,000 0,08736289 0,13362691 ! organelle fusion GO:0048284 32 13 0,000 0,08736289 0,13354201 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,08736289 0,13345722 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,08736289 0,13337254 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,08736289 0,13328797 ! endocrine pancreas development GO:0031018 22 13 0,000 0,08736289 0,1332035 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,08736289 0,13311914 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,08736289 0,13303489 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,08736289 0,13295074 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,08736289 0,1328667 ! methionine metabolic process GO:0006555 27 13 0,000 0,08736289 0,13278277 ! plasma membrane organization GO:0007009 24 13 0,000 0,08736289 0,13269894 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,08736289 0,13261522 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,08736289 0,1325316 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,08736289 0,13244809 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,08736289 0,13236469 ! cell-cell junction assembly GO:0007043 27 13 0,000 0,08736289 0,13228139 ! cytokine metabolic process GO:0042107 22 13 0,000 0,08736289 0,13219819 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,08736289 0,1321151 ! exocrine system development GO:0035272 32 13 0,000 0,08736289 0,13203211 ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,08736289 0,13194923 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,08736289 0,13186645 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,08736289 0,13178378 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,08736289 0,13170121 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,08736289 0,13161874 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,08736289 0,13153637 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,08736289 0,13145411 ! ribosome assembly GO:0042255 17 13 0,000 0,08736289 0,13137195 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,08736289 0,1312899 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,08736289 0,13120794 ! chromatin silencing GO:0006342 26 13 0,000 0,08736289 0,13112609 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,08736289 0,13104434 ! regulation of epidermis development GO:0045682 19 13 0,000 0,08736289 0,13096269 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08736289 0,13088115 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,08736289 0,1307997 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,08736289 0,13071836 ! regulation of mRNA stability GO:0043488 31 13 0,000 0,08736289 0,13063712 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,08736289 0,13055598 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,08736289 0,13047494 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,08736289 0,130394 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,08736289 0,13031316 ! embryonic placenta development GO:0001892 23 13 0,000 0,08736289 0,13023242 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,08736289 0,13015178 ! insulin secretion GO:0030073 23 13 0,000 0,08736289 0,13007124 ! actin filament polymerization GO:0030041 24 13 0,000 0,08736289 0,1299908 ! cytoplasmic sequestering of protein GO:0051220 24 13 0,000 0,08736289 0,12991046 ! acrosome reaction GO:0007340 18 13 0,000 0,08736289 0,12983022 ! reproductive structure development GO:0048608 113 71 1,000 0,08870501 0,13174337 ! B cell activation GO:0042113 160 71 1,000 0,08870501 0,1316621 ! carbohydrate transport GO:0008643 110 72 1,000 0,09083408 0,13473909 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 1,000 0,09083408 0,13465607 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 1,000 0,09083408 0,13457315 ! rRNA transcription GO:0009303 25 14 0,000 0,0937596 0,13882191 ! lactation GO:0007595 26 14 0,000 0,0937596 0,13873653 ! reproductive cellular process GO:0048610 20 14 0,000 0,0937596 0,13865126 ! tRNA modification GO:0006400 20 14 0,000 0,0937596 0,13856609 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,0937596 0,13848103 ! regulation of S phase GO:0033261 23 14 0,000 0,0937596 0,13839607 ! water transport GO:0006833 21 14 0,000 0,0937596 0,13831122 GO:0042044|fluid transport, ! non-recombinational repair GO:0000726 25 14 0,000 0,0937596 0,13822647 GO:0006303|double-strand break repair via nonhomologous end joining, ! positive regulation of GTPase activity GO:0043547 36 14 0,000 0,0937596 0,13814182 ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,0937596 0,13805728 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,0937596 0,13797284 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,0937596 0,13788851 ! palate development GO:0060021 31 14 0,000 0,0937596 0,13780427 ! regulated secretory pathway GO:0045055 23 14 0,000 0,0937596 0,13772014 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,0937596 0,13763612 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,0937596 0,13755219 ! arginine metabolic process GO:0006525 17 14 0,000 0,0937596 0,13746837 ! regulation of heart rate GO:0002027 24 14 0,000 0,0937596 0,13738465 ! organic alcohol transport GO:0015850 29 14 0,000 0,0937596 0,13730103 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,0937596 0,13721752 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 0,000 0,0937596 0,1371341 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,0937596 0,13705079 ! neutral amino acid transport GO:0015804 26 14 0,000 0,0937596 0,13696758 ! L-amino acid transport GO:0015807 30 14 0,000 0,0937596 0,13688446 ! bone mineralization GO:0030282 17 14 0,000 0,0937596 0,13680145 ! stem cell development GO:0048864 43 14 0,000 0,0937596 0,13671854 GO:0019827|stem cell maintenance, ! negative regulation of protein import into nucleus GO:0042308 30 14 0,000 0,0937596 0,13663573 ! T cell differentiation in the thymus GO:0033077 31 14 0,000 0,0937596 0,13655302 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,0937596 0,13647042 ! cerebellum development GO:0021549 21 14 0,000 0,0937596 0,13638791 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,0937596 0,1363055 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,0937596 0,13622319 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,0937596 0,13614098 ! NADP metabolic process GO:0006739 24 14 0,000 0,0937596 0,13605886 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,0937596 0,13597685 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,0937596 0,13589494 ! intestinal absorption GO:0050892 25 14 0,000 0,0937596 0,13581312 ! cAMP biosynthetic process GO:0006171 23 14 0,000 0,0937596 0,13573141 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,0937596 0,13564979 ! male genitalia development GO:0030539 24 14 0,000 0,0937596 0,13556827 ! regulation of axon extension GO:0030516 37 14 0,000 0,0937596 0,13548685 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,0937596 0,13540552 ! transition metal ion transport GO:0000041 126 74 1,000 0,09513681 0,13731204 ! regulation of actin cytoskeleton organization GO:0032956 149 74 1,000 0,09513681 0,13722971 ! eye development GO:0001654 143 74 1,000 0,09513681 0,13714749 ! cell-matrix adhesion GO:0007160 163 75 1,000 0,09730985 0,14019611 ! lymphocyte differentiation GO:0030098 167 75 1,000 0,09730985 0,14011221 ! development of primary sexual characteristics GO:0045137 124 76 1,000 0,09949693 0,14317561 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,10011168 0,14397412 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,10011168 0,14388812 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,10011168 0,14380221 ! superoxide anion generation GO:0042554 20 15 0,000 0,10011168 0,14371641 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,10011168 0,14363071 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,10011168 0,14354512 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,10011168 0,14345962 ! sulfate transport GO:0008272 23 15 0,000 0,10011168 0,14337423 ! response to cAMP GO:0051591 22 15 0,000 0,10011168 0,14328894 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,10011168 0,14320375 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,10011168 0,14311866 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,10011168 0,14303367 ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,10011168 0,14294879 ! response to hexose stimulus GO:0009746 22 15 0,000 0,10011168 0,142864 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,10011168 0,14277932 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,10011168 0,14269473 ! pituitary gland development GO:0021983 29 15 0,000 0,10011168 0,14261025 ! vesicle coating GO:0006901 33 15 0,000 0,10011168 0,14252586 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,10011168 0,14244158 ! regulation of exocytosis GO:0017157 22 15 0,000 0,10011168 0,14235739 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,10011168 0,14227331 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,10011168 0,14218932 ! regulation of vasodilation GO:0042312 26 15 0,000 0,10011168 0,14210543 ! regulation of T cell mediated immunity GO:0002709 33 15 0,000 0,10011168 0,14202164 ! histone deacetylation GO:0016575 20 15 0,000 0,10011168 0,14193795 ! mRNA splice site selection GO:0006376 38 15 0,000 0,10011168 0,14185436 ! tissue regeneration GO:0042246 26 15 0,000 0,10011168 0,14177087 ! water homeostasis GO:0030104 27 15 0,000 0,10011168 0,14168747 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,10011168 0,14160418 ! muscle maintenance GO:0046716 26 15 0,000 0,10011168 0,14152098 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 0,000 0,10011168 0,14143788 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,10011168 0,14135487 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,10011168 0,14127197 ! dopamine metabolic process GO:0042417 35 15 0,000 0,10011168 0,14118916 ! heme biosynthetic process GO:0006783 29 15 0,000 0,10011168 0,14110645 ! cell killing GO:0001906 29 15 0,000 0,10011168 0,14102383 ! detection of bacterium GO:0016045 18 15 0,000 0,10011168 0,14094131 ! epithelial to mesenchymal transition GO:0001837 28 15 0,000 0,10011168 0,14085889 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,10011168 0,14077657 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,10011168 0,14069434 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,10011168 0,1406122 ! peptide hormone processing GO:0016486 23 15 0,000 0,10011168 0,14053017 ! regulation of actin filament-based process GO:0032970 152 77 1,000 0,10169776 0,14267336 ! positive regulation of ligase activity GO:0051351 124 77 1,000 0,10169776 0,14259022 ! regulation of synaptic transmission GO:0050804 134 79 1,000 0,10613945 0,14873123 ! regulation of protein ubiquitination GO:0031396 25 16 0,000 0,10641945 0,14903678 ! G1 phase of mitotic cell cycle GO:0000080 35 16 0,000 0,10641945 0,14895009 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,10641945 0,14886349 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,10641945 0,14877699 ! embryonic forelimb morphogenesis GO:0035115 28 16 0,000 0,10641945 0,14869059 ! filopodium assembly GO:0046847 32 16 0,000 0,10641945 0,14860429 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 0,000 0,10641945 0,1485181 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,10641945 0,148432 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,10641945 0,148346 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,10641945 0,1482601 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,10641945 0,1481743 ! startle response GO:0001964 28 16 0,000 0,10641945 0,1480886 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,10641945 0,148003 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,10641945 0,1479175 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,10641945 0,1478321 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,10641945 0,1477468 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,10641945 0,14766159 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,10641945 0,14757648 ! protein polyubiquitination GO:0000209 34 16 0,000 0,10641945 0,14749147 ! glutamate metabolic process GO:0006536 22 16 0,000 0,10641945 0,14740656 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,10641945 0,14732175 ! response to osmotic stress GO:0006970 25 16 0,000 0,10641945 0,14723703 ! lysosomal transport GO:0007041 26 16 0,000 0,10641945 0,14715241 ! fructose metabolic process GO:0006000 25 16 0,000 0,10641945 0,14706789 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,10641945 0,14698347 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,10641945 0,14689914 ! negative regulation of immune response GO:0050777 35 16 0,000 0,10641945 0,14681491 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,10641945 0,14673077 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,10641945 0,14664673 ! positive regulation of protein import into nucleus GO:0042307 30 16 0,000 0,10641945 0,14656279 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,10641945 0,14647895 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,10641945 0,1463952 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,10641945 0,14631154 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,10641945 0,14622798 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,10641945 0,14614452 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,10641945 0,14606115 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,10641945 0,14597788 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,10641945 0,1458947 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 0,000 0,10641945 0,14581162 ! defense response to virus GO:0051607 37 16 0,000 0,10641945 0,14572863 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,10837974 0,14832858 ! cell-substrate adhesion GO:0031589 171 81 1,000 0,11063259 0,15132576 ! positive regulation of cell killing GO:0031343 32 17 0,000 0,11268321 0,15404307 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,11268321 0,1539556 ! metencephalon development GO:0022037 30 17 0,000 0,11268321 0,15386822 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,11268321 0,15378095 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,11268321 0,15369377 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,11268321 0,15360669 ! signal complex assembly GO:0007172 41 17 0,000 0,11268321 0,15351971 ! gene silencing by RNA GO:0031047 36 17 0,000 0,11268321 0,15343283 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,11268321 0,15334604 ! glial cell development GO:0021782 27 17 0,000 0,11268321 0,15325936 ! limbic system development GO:0021761 36 17 0,000 0,11268321 0,15317277 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,11268321 0,15308628 ! adult walking behavior GO:0007628 33 17 0,000 0,11268321 0,15299989 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,11268321 0,1529136 ! heart looping GO:0001947 30 17 0,000 0,11268321 0,1528274 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,11268321 0,1527413 ! myoblast differentiation GO:0045445 45 17 0,000 0,11268321 0,1526553 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,11268321 0,15256939 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,11268321 0,15248358 ! glycine metabolic process GO:0006544 28 17 0,000 0,11268321 0,15239787 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,11268321 0,15231225 ! NAD metabolic process GO:0019674 29 17 0,000 0,11268321 0,15222673 ! membrane budding GO:0006900 37 17 0,000 0,11268321 0,15214131 ! DNA integration GO:0015074 29 17 0,000 0,11268321 0,15205598 ! regulation of protein binding GO:0043393 33 17 0,000 0,11268321 0,15197074 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,11268321 0,15188561 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,11268321 0,15180056 ! genitalia development GO:0048806 30 17 0,000 0,11268321 0,15171562 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 0,000 0,11268321 0,15163076 GO:0002712|regulation of B cell mediated immunity, ! neural crest cell migration GO:0001755 37 17 0,000 0,11268321 0,15154601 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,11268321 0,15146135 ! steroid catabolic process GO:0006706 31 17 0,000 0,11268321 0,15137678 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,11268321 0,1512923 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,11268321 0,15120792 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,11268321 0,15112364 ! negative regulation of homeostatic process GO:0032845 33 17 0,000 0,11268321 0,15103945 ! microspike assembly GO:0030035 36 17 0,000 0,11268321 0,15095535 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 0,000 0,11268321 0,15087135 ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,11289773 0,1510745 ! response to drug GO:0042493 143 82 1,000 0,11289773 0,15099052 ! response to nutrient GO:0007584 125 82 1,000 0,11289773 0,15090664 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,11289773 0,15082285 ! regulation of lyase activity GO:0051339 160 83 1,000 0,11517489 0,15377956 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,11746377 0,15674865 ! regulation of transmission of nerve impulse GO:0051969 141 84 1,000 0,11746377 0,15666176 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,11890327 0,15849378 ! neuron maturation GO:0042551 42 18 0,000 0,11890327 0,15840602 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,11890327 0,15831836 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,11890327 0,15823079 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,11890327 0,15814332 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,11890327 0,15805595 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,11890327 0,15796868 ! memory GO:0007613 31 18 0,000 0,11890327 0,1578815 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,11890327 0,15779442 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 24 18 0,000 0,11890327 0,15770743 ! patterning of blood vessels GO:0001569 39 18 0,000 0,11890327 0,15762054 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,11890327 0,15753374 GO:0042744|hydrogen peroxide catabolic process, ! glutamine metabolic process GO:0006541 29 18 0,000 0,11890327 0,15744704 ! response to retinoic acid GO:0032526 26 18 0,000 0,11890327 0,15736044 ! cell-substrate junction assembly GO:0007044 54 18 0,000 0,11890327 0,15727393 ! response to fungus GO:0009620 21 18 0,000 0,11890327 0,15718751 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,11890327 0,15710119 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,11890327 0,15701497 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,11890327 0,15692884 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,11890327 0,1568428 ! regulation of immunoglobulin production GO:0002637 43 18 0,000 0,11890327 0,15675686 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,11890327 0,15667102 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,11890327 0,15658526 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,11890327 0,1564996 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,11890327 0,15641404 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,11890327 0,15632857 ! response to unfolded protein GO:0006986 131 85 1,000 0,11976411 0,15737435 ! nucleosome assembly GO:0006334 122 85 1,000 0,11976411 0,15728845 ! chromatin assembly GO:0031497 124 86 1,000 0,12207563 0,16023675 ! amine transport GO:0015837 155 86 1,000 0,12207563 0,16014938 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,12439807 0,16310723 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! nitrogen compound catabolic process GO:0044270 143 87 1,000 0,12439807 0,16301839 ! regulation of protein transport GO:0051223 154 87 1,000 0,12439807 0,16292965 GO:0070201|regulation of establishment of protein localization, ! protein secretion GO:0009306 39 19 0,000 0,12507994 0,16373358 ! positive regulation of translation GO:0045727 30 19 0,000 0,12507994 0,16364455 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,12507994 0,16355561 ! skin development GO:0043588 36 19 0,000 0,12507994 0,16346677 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,12507994 0,16337803 ! forelimb morphogenesis GO:0035136 32 19 0,000 0,12507994 0,16328938 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,12507994 0,16320083 ! bile acid metabolic process GO:0008206 29 19 0,000 0,12507994 0,16311237 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,12507994 0,16302401 ! cerebral cortex development GO:0021987 36 19 0,000 0,12507994 0,16293575 ! pigmentation during development GO:0048066 41 19 0,000 0,12507994 0,16284758 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,12507994 0,16275951 GO:0030968|endoplasmic reticulum unfolded protein response, ! response to vitamin A GO:0033189 27 19 0,000 0,12507994 0,16267153 ! heme metabolic process GO:0042168 36 19 0,000 0,12507994 0,16258365 ! actin filament bundle formation GO:0051017 42 19 0,000 0,12507994 0,16249586 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,12507994 0,16240816 ! regulation of endothelial cell migration GO:0010594 44 19 0,000 0,12507994 0,16232057 ! peptide cross-linking GO:0018149 37 19 0,000 0,12507994 0,16223306 ! protein export from nucleus GO:0006611 36 19 0,000 0,12507994 0,16214565 ! heart process GO:0003015 30 19 0,000 0,12507994 0,16205834 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,12507994 0,16197111 GO:0006692|prostanoid metabolic process, ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 0,000 0,12507994 0,16188399 ! visual learning GO:0008542 36 19 0,000 0,12507994 0,16179695 ! cellular pigmentation GO:0033059 36 19 0,000 0,12507994 0,16171001 ! G1 phase GO:0051318 40 19 0,000 0,12507994 0,16162316 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 0,000 0,12507994 0,16153641 ! cell-cell junction organization GO:0045216 35 19 0,000 0,12507994 0,16144975 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,12507994 0,16136318 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,12507994 0,1612767 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,12507994 0,16119032 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,12507994 0,16110403 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,12507994 0,16101783 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,12507994 0,16093173 ! cilium assembly GO:0042384 37 19 0,000 0,12507994 0,16084571 ! peptide hormone secretion GO:0030072 31 19 0,000 0,12507994 0,16075979 ! regulation of neurological system process GO:0031644 148 88 1,000 0,12673117 0,16279508 ! regulation of cell morphogenesis GO:0022604 215 89 1,000 0,12907466 0,16571698 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,13121351 0,16837317 ! positive regulation of ossification GO:0045778 47 20 0,000 0,13121351 0,16828342 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,13121351 0,16819376 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,13121351 0,1681042 ! cAMP metabolic process GO:0046058 36 20 0,000 0,13121351 0,16801474 ! response to vitamin GO:0033273 31 20 0,000 0,13121351 0,16792537 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,13121351 0,16783609 ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,13121351 0,16774691 ! C21-steroid hormone metabolic process GO:0008207 33 20 0,000 0,13121351 0,16765783 ! response to alkaloid GO:0043279 38 20 0,000 0,13121351 0,16756884 ! retinoid metabolic process GO:0001523 32 20 0,000 0,13121351 0,16747994 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,13121351 0,16739114 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,13121351 0,16730243 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,13121351 0,16721382 ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,13121351 0,1671253 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,13121351 0,16703687 ! fatty acid beta-oxidation GO:0006635 34 20 0,000 0,13121351 0,16694854 ! peptide secretion GO:0002790 35 20 0,000 0,13121351 0,1668603 ! stem cell differentiation GO:0048863 53 20 0,000 0,13121351 0,16677216 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,13121351 0,1666841 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,13121351 0,16659614 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,13121351 0,16650828 ! sensory perception of pain GO:0019233 30 20 0,000 0,13121351 0,1664205 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,13121351 0,16633282 ! diencephalon development GO:0021536 34 20 0,000 0,13121351 0,16624523 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,13121351 0,16615773 GO:0006626|protein targeting to mitochondrion, ! negative regulation of angiogenesis GO:0016525 45 20 0,000 0,13121351 0,16607033 ! detection of chemical stimulus GO:0009593 37 20 0,000 0,13121351 0,16598301 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,13121351 0,16589579 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,13121351 0,16580866 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,13121351 0,16572162 GO:0043450|alkene biosynthetic process, ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 0,000 0,13121351 0,16563468 ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,13121351 0,16554782 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,13121351 0,16546106 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,13121351 0,16537438 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,13121351 0,1652878 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,13142828 0,16547171 ! sex differentiation GO:0007548 145 90 1,000 0,13142828 0,16538517 ! protein-DNA complex assembly GO:0065004 130 90 1,000 0,13142828 0,16529871 ! response to protein stimulus GO:0051789 149 91 1,000 0,13379178 0,1681834 ! vitamin metabolic process GO:0006766 139 92 1,000 0,13616491 0,17107717 ! regulation of cell killing GO:0031341 42 21 0,000 0,13730428 0,17241863 ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,13730428 0,17232869 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,13730428 0,17223884 ! hormone secretion GO:0046879 38 21 0,000 0,13730428 0,17214908 ! glycerol metabolic process GO:0006071 34 21 0,000 0,13730428 0,17205942 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,13730428 0,17196985 ! hindlimb morphogenesis GO:0035137 43 21 0,000 0,13730428 0,17188038 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,13730428 0,171791 ! axis specification GO:0009798 38 21 0,000 0,13730428 0,17170171 ! ovarian follicle development GO:0001541 35 21 0,000 0,13730428 0,17161251 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,13730428 0,17152341 ! cytolysis GO:0019835 24 21 0,000 0,13730428 0,1714344 ! vasodilation GO:0042311 39 21 0,000 0,13730428 0,17134548 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,13730428 0,17125666 ! regulation of vasoconstriction GO:0019229 39 21 0,000 0,13730428 0,17116792 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,13730428 0,17107928 ! oogenesis GO:0048477 36 21 0,000 0,13730428 0,17099073 ! collagen fibril organization GO:0030199 59 21 0,000 0,13730428 0,17090227 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,13730428 0,1708139 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 0,000 0,13730428 0,17072563 ! negative regulation of intracellular transport GO:0032387 41 21 0,000 0,13730428 0,17063744 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,13730428 0,17054935 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,13730428 0,17046135 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,13730428 0,17037343 ! response to cytokine stimulus GO:0034097 63 21 0,000 0,13730428 0,17028561 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,13730428 0,17019788 ! collagen catabolic process GO:0030574 28 21 0,000 0,13730428 0,17011024 ! sperm-egg recognition GO:0035036 21 21 0,000 0,13730428 0,17002269 ! gut development GO:0048565 39 21 0,000 0,13730428 0,16993523 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 1,000 0,13854742 0,17138565 GO:0010498|proteasomal protein catabolic process, ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,13854742 0,17129758 ! carbohydrate biosynthetic process GO:0016051 141 93 1,000 0,13854742 0,17120959 ! regulation of membrane potential GO:0042391 164 93 1,000 0,13854742 0,1711217 ! biogenic amine metabolic process GO:0006576 155 94 1,000 0,14093905 0,17398633 ! forebrain development GO:0030900 188 95 1,000 0,14333958 0,17685899 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,14335255 0,17678433 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,14335255 0,17669377 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,14335255 0,17660329 GO:0034105|positive regulation of tissue remodeling, ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,14335255 0,17651291 ! regeneration GO:0031099 41 22 0,000 0,14335255 0,17642263 ! keratinization GO:0031424 28 22 0,000 0,14335255 0,17633243 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,14335255 0,17624233 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,14335255 0,17615231 ! sensory perception of taste GO:0050909 28 22 0,000 0,14335255 0,1760624 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,14335255 0,17597257 ! vacuolar transport GO:0007034 36 22 0,000 0,14335255 0,17588283 ! lysosome organization GO:0007040 41 22 0,000 0,14335255 0,17579319 ! central nervous system neuron development GO:0021954 46 22 0,000 0,14335255 0,17570363 ! cellular response to reactive oxygen species GO:0034614 31 22 0,000 0,14335255 0,17561417 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,14335255 0,1755248 ! fucose metabolic process GO:0006004 39 22 0,000 0,14335255 0,17543552 ! vesicle docking during exocytosis GO:0006904 41 22 0,000 0,14335255 0,17534633 ! ureteric bud development GO:0001657 43 22 0,000 0,14335255 0,17525723 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,14335255 0,17516822 GO:0060415|muscle tissue morphogenesis, ! renal system process GO:0003014 41 22 0,000 0,14335255 0,17507931 ! positive regulation of adaptive immune response GO:0002821 39 22 0,000 0,14335255 0,17499048 ! response to glucocorticoid stimulus GO:0051384 38 22 0,000 0,14335255 0,17490174 ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,14335255 0,17481309 ! sarcomere organization GO:0045214 30 22 0,000 0,14335255 0,17472454 ! activation of JUN kinase activity GO:0007257 42 22 0,000 0,14335255 0,17463607 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,14335255 0,17454769 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,14335255 0,1744594 ! protein stabilization GO:0050821 39 22 0,000 0,14335255 0,1743712 ! protein ubiquitination GO:0016567 217 97 1,000 0,14816634 0,18013553 ! regulation of protein localization GO:0032880 176 97 1,000 0,14816634 0,18004455 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,14935862 0,18140173 ! gluconeogenesis GO:0006094 33 23 0,000 0,14935862 0,18131021 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,14935862 0,18121878 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,14935862 0,18112744 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,14935862 0,18103619 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,14935862 0,18094503 GO:0006044|N-acetylglucosamine metabolic process, ! leukocyte adhesion GO:0007159 50 23 0,000 0,14935862 0,18085397 ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,14935862 0,18076299 ! visual behavior GO:0007632 42 23 0,000 0,14935862 0,18067211 ! regulation of DNA recombination GO:0000018 48 23 0,000 0,14935862 0,18058132 ! response to ethanol GO:0045471 46 23 0,000 0,14935862 0,18049062 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 0,000 0,14935862 0,18040002 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! peroxisome organization GO:0007031 37 23 0,000 0,14935862 0,1803095 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,14935862 0,18021907 ! vesicle targeting GO:0006903 43 23 0,000 0,14935862 0,18012874 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 0,000 0,14935862 0,18003849 ! leukotriene metabolic process GO:0006691 42 23 0,000 0,14935862 0,17994834 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,14935862 0,17985827 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,14935862 0,1797683 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,14935862 0,17967842 ! fatty acid transport GO:0015908 44 23 0,000 0,14935862 0,17958862 ! platelet activation GO:0030168 37 23 0,000 0,14935862 0,17949892 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,14935862 0,1794093 ! hormone transport GO:0009914 40 23 0,000 0,14935862 0,17931978 ! cell-cell recognition GO:0009988 25 23 0,000 0,14935862 0,17923034 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,14935862 0,17914099 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,14935862 0,17905173 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,14935862 0,17896257 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,14935862 0,17887349 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 1,000 0,15302581 0,18317418 ! Golgi vesicle transport GO:0048193 207 99 1,000 0,15302581 0,18308309 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,15532277 0,18573886 GO:0016444|somatic cell DNA recombination, ! vesicle docking GO:0048278 47 24 0,000 0,15532277 0,18564659 ! spinal cord development GO:0021510 47 24 0,000 0,15532277 0,18555442 ! vacuole organization GO:0007033 43 24 0,000 0,15532277 0,18546233 ! multicellular organismal response to stress GO:0033555 49 24 0,000 0,15532277 0,18537033 ! digestive system process GO:0022600 39 24 0,000 0,15532277 0,18527843 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,15532277 0,18518662 ! response to corticosteroid stimulus GO:0031960 41 24 0,000 0,15532277 0,18509489 ! lymphocyte proliferation GO:0046651 48 24 0,000 0,15532277 0,18500326 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 0,000 0,15532277 0,18491172 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,15532277 0,18482027 ! membrane depolarization GO:0051899 39 24 0,000 0,15532277 0,18472891 ! pallium development GO:0021543 49 24 0,000 0,15532277 0,18463764 ! pentose metabolic process GO:0019321 35 24 0,000 0,15532277 0,18454647 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,15532277 0,18445538 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,15532277 0,18436438 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,15532277 0,18427347 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,15532277 0,18418265 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,15532277 0,18409192 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,15532277 0,18400128 ! regulation of amine transport GO:0051952 40 24 0,000 0,15532277 0,18391072 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,16124531 0,19082942 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,16124531 0,1907356 ! phototransduction GO:0007602 33 25 0,000 0,16124531 0,19064188 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,16124531 0,19054824 GO:0006479|protein amino acid methylation, ! sperm motility GO:0030317 31 25 0,000 0,16124531 0,1904547 ! regulation of smooth muscle contraction GO:0006940 43 25 0,000 0,16124531 0,19036124 ! receptor metabolic process GO:0043112 46 25 0,000 0,16124531 0,19026788 ! osteoblast differentiation GO:0001649 60 25 0,000 0,16124531 0,19017462 ! neural crest cell development GO:0014032 54 25 0,000 0,16124531 0,19008144 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,16124531 0,18998835 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,16124531 0,18989536 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,16124531 0,18980245 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,16124531 0,18970964 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! immunoglobulin production GO:0002377 55 25 0,000 0,16124531 0,18961692 GO:0002440|production of molecular mediator of immune response, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,16124531 0,18952429 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,16124531 0,18943175 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,16124531 0,1893393 ! telomere organization GO:0032200 43 25 0,000 0,16124531 0,18924693 GO:0000723|telomere maintenance, ! neural tube closure GO:0001843 49 25 0,000 0,16124531 0,18915466 GO:0060606|tube closure, ! liver development GO:0001889 53 25 0,000 0,16124531 0,18906248 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,16712652 0,19586283 ! embryonic pattern specification GO:0009880 44 26 0,000 0,16712652 0,19576748 ! initiation of viral infection GO:0019059 57 26 0,000 0,16712652 0,19567221 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,16712652 0,19557704 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,16712652 0,19548196 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,16712652 0,19538698 ! tube lumen formation GO:0035148 50 26 0,000 0,16712652 0,19529208 ! regulation of transcription factor import into nucleus GO:0042990 54 26 0,000 0,16712652 0,19519728 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,16712652 0,19510257 ! regulation of endothelial cell proliferation GO:0001936 57 26 0,000 0,16712652 0,19500795 ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,16712652 0,19491343 ! cellular response to oxidative stress GO:0034599 39 26 0,000 0,16712652 0,19481899 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,16712652 0,19472465 ! positive regulation of MAPKKK cascade GO:0043410 47 26 0,000 0,16712652 0,1946304 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,16712652 0,19453623 ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,16712652 0,19444216 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,16712652 0,19434819 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,16712652 0,1942543 ! blastocyst development GO:0001824 49 26 0,000 0,16712652 0,1941605 ! leukocyte proliferation GO:0070661 52 26 0,000 0,16712652 0,19406679 GO:0032943|mononuclear cell proliferation, ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,16712652 0,19397318 ! positive regulation of JUN kinase activity GO:0043507 51 26 0,000 0,16712652 0,19387965 ! neuron fate commitment GO:0048663 48 27 0,000 0,17296668 0,20055799 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 0,000 0,17296668 0,20046138 ! positive regulation of cell projection organization GO:0031346 58 27 0,000 0,17296668 0,20036487 ! iron ion transport GO:0006826 59 27 0,000 0,17296668 0,20026844 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,17296668 0,20017211 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,17296668 0,20007588 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,17296668 0,19997973 ! fat cell differentiation GO:0045444 50 27 0,000 0,17296668 0,19988368 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,17296668 0,19978772 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,17296668 0,19969185 ! autophagy GO:0006914 41 27 0,000 0,17296668 0,19959608 ! response to toxin GO:0009636 47 27 0,000 0,17296668 0,1995004 ! primary neural tube formation GO:0014020 51 27 0,000 0,17296668 0,1994048 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 0,000 0,17296668 0,1993093 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,17296668 0,19921389 ! glutathione metabolic process GO:0006749 39 27 0,000 0,17296668 0,19911858 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,17296668 0,19902335 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,17296668 0,19892821 ! circadian rhythm GO:0007623 50 28 0,000 0,17876608 0,20549985 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,17876608 0,20540171 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,17876608 0,20530367 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,17876608 0,20520572 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,17876608 0,20510786 ! regulation of systemic arterial blood pressure GO:0003073 54 28 0,000 0,17876608 0,2050101 ! lipid oxidation GO:0034440 43 28 0,000 0,17876608 0,20491243 GO:0019395|fatty acid oxidation, ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,17876608 0,20481485 ! regulation of JUN kinase activity GO:0043506 58 28 0,000 0,17876608 0,20471737 ! translational initiation GO:0006413 65 29 0,000 0,18452501 0,21121178 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,18452501 0,21111135 ! cellular iron ion homeostasis GO:0006879 51 29 0,000 0,18452501 0,21101101 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,18452501 0,21091077 ! catechol metabolic process GO:0009712 54 29 0,000 0,18452501 0,21081062 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,18452501 0,21071057 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,18452501 0,21061061 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,18452501 0,21051075 ! immune response-activating signal transduction GO:0002757 47 29 0,000 0,18452501 0,21041098 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 0,000 0,18452501 0,21031131 ! response to organic cyclic substance GO:0014070 55 29 0,000 0,18452501 0,21021173 ! cell fate determination GO:0001709 60 29 0,000 0,18452501 0,21011224 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,18452501 0,21001285 ! detection of light stimulus GO:0009583 38 29 0,000 0,18452501 0,20991355 ! negative regulation of neuron apoptosis GO:0043524 56 29 0,000 0,18452501 0,20981435 ! tissue homeostasis GO:0001894 48 29 0,000 0,18452501 0,20971524 GO:0048871|multicellular organismal homeostasis, ! phenol metabolic process GO:0018958 55 30 0,000 0,19024374 0,21611258 ! zinc ion transport GO:0006829 45 30 0,000 0,19024374 0,21601059 ! membrane docking GO:0022406 61 30 0,000 0,19024374 0,2159087 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,19024374 0,2158069 ! cell junction assembly GO:0034329 78 30 0,000 0,19024374 0,2157052 ! regulation of innate immune response GO:0045088 51 30 0,000 0,19024374 0,2156036 ! acute-phase response GO:0006953 49 30 0,000 0,19024374 0,21550209 ! determination of left/right symmetry GO:0007368 47 30 0,000 0,19024374 0,21540068 ! phospholipid transport GO:0015914 51 30 0,000 0,19024374 0,21529936 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,19024374 0,21519814 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,19024374 0,21509701 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,19024374 0,21499598 ! eye morphogenesis GO:0048592 60 30 0,000 0,19024374 0,21489504 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,19592256 0,22120585 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,19592256 0,2211021 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,19592256 0,22099844 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,19592256 0,22089488 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,19592256 0,22079142 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,19592256 0,22068805 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,19592256 0,22058478 ! ovulation cycle process GO:0022602 49 31 0,000 0,19592256 0,22048161 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,19592256 0,22037853 ! peptide transport GO:0015833 55 31 0,000 0,19592256 0,22027555 ! iron ion homeostasis GO:0055072 54 31 0,000 0,19592256 0,22017266 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,19592256 0,22006987 ! natural killer cell activation GO:0030101 45 31 0,000 0,19592256 0,21996718 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,19592256 0,21986459 ! fatty acid catabolic process GO:0009062 48 31 0,000 0,19592256 0,21976208 ! myeloid leukocyte activation GO:0002274 49 31 0,000 0,19592256 0,21965968 ! positive regulation of immune effector process GO:0002699 67 31 0,000 0,19592256 0,21955737 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,20156174 0,22577166 ! response to hydrogen peroxide GO:0042542 50 32 0,000 0,20156174 0,22566661 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,20156174 0,22556164 ! cholesterol transport GO:0030301 56 32 0,000 0,20156174 0,22545678 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,20156174 0,22535202 ! spliceosome assembly GO:0000245 67 32 0,000 0,20156174 0,22524735 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,20156174 0,22514277 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,20156174 0,2250383 ! response to mechanical stimulus GO:0009612 57 32 0,000 0,20156174 0,22493392 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,20156174 0,22482964 ! regulation of protein import into nucleus GO:0042306 63 32 0,000 0,20156174 0,22472546 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,20156174 0,22462137 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,20156174 0,22451738 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,20156174 0,22441348 ! ovulation cycle GO:0042698 51 32 0,000 0,20156174 0,22430968 ! BMP signaling pathway GO:0030509 64 32 0,000 0,20156174 0,22420598 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,20156174 0,22410237 ! gene silencing GO:0016458 65 32 0,000 0,20156174 0,22399886 ! post-embryonic development GO:0009791 69 33 0,000 0,20716155 0,23011574 ! protein targeting to membrane GO:0006612 68 33 0,000 0,20716155 0,23000955 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,20716155 0,22990346 ! ceramide metabolic process GO:0006672 64 33 0,000 0,20716155 0,22979746 ! sterol transport GO:0015918 57 33 0,000 0,20716155 0,22969156 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,20716155 0,22958576 ! adult locomotory behavior GO:0008344 59 33 0,000 0,20716155 0,22948006 ! negative regulation of protein transport GO:0051224 69 33 0,000 0,20716155 0,22937446 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,20716155 0,22926895 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,21272228 0,23531485 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,21272228 0,23520671 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,21272228 0,23509867 ! regulation of striated muscle tissue development GO:0016202 69 34 0,000 0,21272228 0,23499073 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,21272228 0,23488288 ! mismatch repair GO:0006298 46 34 0,000 0,21272228 0,23477514 ! spermatid development GO:0007286 63 34 0,000 0,21272228 0,23466749 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,21272228 0,23455995 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,21272228 0,2344525 ! regulation of muscle development GO:0048634 70 35 0,000 0,21824419 0,24042835 ! negative regulation of secretion GO:0051048 63 35 0,000 0,21824419 0,24031831 ! odontogenesis GO:0042476 66 35 0,000 0,21824419 0,24020838 ! female gonad development GO:0008585 58 35 0,000 0,21824419 0,24009854 ! telencephalon development GO:0021537 68 35 0,000 0,21824419 0,23998881 ! cytokine production GO:0001816 59 35 0,000 0,21824419 0,23987918 ! neural tube formation GO:0001841 67 35 0,000 0,21824419 0,23976964 ! vesicle localization GO:0051648 64 35 0,000 0,21824419 0,23966021 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,22372755 0,24556956 ! cell junction organization GO:0034330 86 36 0,000 0,22372755 0,24545759 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,22372755 0,24534571 ! maintenance of protein location in cell GO:0032507 86 36 0,000 0,22372755 0,24523393 ! positive regulation of cell development GO:0010720 80 36 0,000 0,22372755 0,24512226 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 0,000 0,22372755 0,24501069 ! hormone biosynthetic process GO:0042446 57 36 0,000 0,22372755 0,24489922 ! aerobic respiration GO:0009060 55 36 0,000 0,22372755 0,24478785 ! embryonic organ development GO:0048568 57 36 0,000 0,22372755 0,24467658 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,22372755 0,24456542 ! RNA export from nucleus GO:0006405 56 37 0,000 0,22917263 0,25040388 ! organic anion transport GO:0015711 68 37 0,000 0,22917263 0,25029022 ! cyclic nucleotide metabolic process GO:0009187 63 37 0,000 0,22917263 0,25017666 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,22917263 0,2500632 GO:0015986|ATP synthesis coupled proton transport, ! pigment metabolic process GO:0042440 80 37 0,000 0,22917263 0,24994984 ! spermatid differentiation GO:0048515 66 37 0,000 0,22917263 0,24983659 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,2345797 0,25561538 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,2345797 0,25549966 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,2345797 0,25538405 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,2345797 0,25526855 ! development of primary female sexual characteristics GO:0046545 67 38 0,000 0,2345797 0,25515314 GO:0046660|female sex differentiation, ! lipid homeostasis GO:0055088 67 38 0,000 0,2345797 0,25503785 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,2345797 0,25492265 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,2345797 0,25480756 ! embryonic epithelial tube formation GO:0001838 72 38 0,000 0,2345797 0,25469258 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,2345797 0,2545777 ! mRNA catabolic process GO:0006402 71 39 0,000 0,23994901 0,26028734 ! learning GO:0007612 77 39 0,000 0,23994901 0,26017005 ! ear morphogenesis GO:0042471 60 39 0,000 0,23994901 0,26005285 ! ion transmembrane transport GO:0034220 66 39 0,000 0,23994901 0,25993576 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 0,000 0,23994901 0,25981878 ! Rho protein signal transduction GO:0007266 74 39 0,000 0,23994901 0,2597019 ! RNA modification GO:0009451 57 39 0,000 0,23994901 0,25958513 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,23994901 0,25946846 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,24528084 0,26511487 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,24528084 0,26499583 ! feeding behavior GO:0007631 59 40 0,000 0,24528084 0,26487689 ! multicellular organismal metabolic process GO:0044236 57 40 0,000 0,24528084 0,26475806 ! mesenchymal cell development GO:0014031 87 40 0,000 0,24528084 0,26463933 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of protein location GO:0045185 91 40 0,000 0,24528084 0,26452071 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,25057545 0,27010955 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,25057545 0,26998859 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,25057545 0,26986774 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,25057545 0,26974699 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,25057545 0,26962635 ! female gamete generation GO:0007292 61 41 0,000 0,25057545 0,26950582 ! response to reactive oxygen species GO:0000302 67 42 0,000 0,25583308 0,27503771 ! regulation of tube size GO:0035150 71 42 0,000 0,25583308 0,27491487 GO:0050880|regulation of blood vessel size, ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,25583308 0,27479214 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,25583308 0,27466952 ! regulation of leukocyte mediated immunity GO:0002703 79 42 0,000 0,25583308 0,27454701 ! regulation of protein secretion GO:0050708 71 42 0,000 0,25583308 0,27442461 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,261054 0,27990015 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,261054 0,27977547 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,261054 0,2796509 ! neural tube development GO:0021915 77 43 0,000 0,261054 0,27952645 ! phagocytosis GO:0006909 90 43 0,000 0,261054 0,2794021 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,261054 0,27927787 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,26623847 0,28469767 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,26623847 0,28457119 ! biopolymer methylation GO:0043414 84 44 0,000 0,26623847 0,28444483 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 0,000 0,26623847 0,28431858 ! maintenance of location in cell GO:0051651 97 44 0,000 0,26623847 0,28419244 ! glycolysis GO:0006096 65 45 0,000 0,27138673 0,28955941 ! detection of stimulus involved in sensory perception GO:0050906 66 45 0,000 0,27138673 0,28943106 ! branching morphogenesis of a tube GO:0048754 97 45 0,000 0,27138673 0,28930282 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,27138673 0,2891747 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,27138673 0,28904669 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,27138673 0,28891879 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,27138673 0,28879101 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,27649904 0,2941011 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,27649904 0,29397114 ! pigmentation GO:0043473 100 46 0,000 0,27649904 0,29384129 ! response to calcium ion GO:0051592 81 47 0,000 0,28157565 0,2991042 ! vascular process in circulatory system GO:0003018 80 47 0,000 0,28157565 0,2989722 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,28157565 0,29884032 ! regulation of adaptive immune response GO:0002819 84 47 0,000 0,28157565 0,29870856 ! JNK cascade GO:0007254 91 47 0,000 0,28157565 0,29857691 ! regulation of JNK cascade GO:0046328 94 47 0,000 0,28157565 0,29844538 ! methylation GO:0032259 90 47 0,000 0,28157565 0,29831396 ! protein homooligomerization GO:0051260 76 47 0,000 0,28157565 0,29818266 ! Notch signaling pathway GO:0007219 96 48 0,000 0,2866168 0,30338761 ! morphogenesis of embryonic epithelium GO:0016331 91 48 0,000 0,2866168 0,30325419 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 0,000 0,2866168 0,30312089 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,2866168 0,30298771 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,2866168 0,30285465 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,29162275 0,30800893 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 0,000 0,29162275 0,30787378 ! regulation of ion transport GO:0043269 77 49 0,000 0,29162275 0,30773875 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,29162275 0,30760383 ! endocrine system development GO:0035270 104 49 0,000 0,29162275 0,30746904 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,29162275 0,30733436 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,29162275 0,3071998 ! detection of abiotic stimulus GO:0009582 74 49 0,000 0,29162275 0,30706536 ! regulation of cell projection organization GO:0031344 121 50 0,000 0,29659374 0,31216296 ! neuromuscular process GO:0050905 99 50 0,000 0,29659374 0,31202647 ! inner ear development GO:0048839 79 50 0,000 0,29659374 0,31189009 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,29659374 0,31175384 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,29659374 0,3116177 ! response to estrogen stimulus GO:0043627 93 51 0,000 0,30153 0,31666573 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,30153 0,31652757 ! excretion GO:0007588 83 51 0,000 0,30153 0,31638953 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,30153 0,31625161 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,30153 0,31611381 ! vesicle organization GO:0016050 107 51 0,000 0,30153 0,31597613 ! epithelial tube morphogenesis GO:0060562 98 51 0,000 0,30153 0,31583857 ! morphogenesis of a branching structure GO:0001763 111 52 0,000 0,30643179 0,32083329 ! amino acid activation GO:0043038 92 52 0,000 0,30643179 0,32069373 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 76 53 0,000 0,31129934 0,32564618 ! RNA catabolic process GO:0006401 93 53 0,000 0,31129934 0,32550466 ! regulation of translational initiation GO:0006446 82 53 0,000 0,31129934 0,32536326 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,31129934 0,32522198 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 0,000 0,31129934 0,32508082 ! cell maturation GO:0048469 100 53 0,000 0,31129934 0,32493979 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,31613289 0,32984204 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,31613289 0,32969906 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,31613289 0,32955621 ! glucose catabolic process GO:0006007 82 55 0,000 0,32093268 0,33441491 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,32093268 0,33427014 ! RNA elongation GO:0006354 79 55 0,000 0,32093268 0,3341255 ! nuclear export GO:0051168 97 55 0,000 0,32093268 0,33398098 ! sensory perception of smell GO:0007608 80 56 0,000 0,32569893 0,33879448 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,32569893 0,33864807 ! proton transport GO:0015992 94 56 0,000 0,32569893 0,33850179 ! hydrogen transport GO:0006818 97 58 0,000 0,33513179 0,34815505 ! regulation of endocytosis GO:0030100 91 58 0,000 0,33513179 0,34800478 ! adult behavior GO:0030534 99 58 0,000 0,33513179 0,34785465 ! positive regulation of secretion GO:0051047 95 59 0,000 0,33979885 0,3525468 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,33979885 0,35239484 GO:0032313|regulation of Rab GTPase activity, ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,34443331 0,35704719 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,34903538 0,36166198 ! tRNA processing GO:0008033 89 61 0,000 0,34903538 0,3615063 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,34903538 0,36135074 ! ear development GO:0043583 103 62 0,000 0,3536053 0,36592445 ! regulation of homeostatic process GO:0032844 134 62 0,000 0,3536053 0,36576713 ! nucleoside monophosphate metabolic process GO:0009123 107 63 0,000 0,35814329 0,370302 ! detection of external stimulus GO:0009581 91 63 0,000 0,35814329 0,37014294 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,35814329 0,36998401 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 0,000 0,36264957 0,37447849 ! cell redox homeostasis GO:0045454 102 64 0,000 0,36264957 0,37431783 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,36264957 0,37415732 ! multicellular organism reproduction GO:0032504 111 64 0,000 0,36264957 0,37399694 GO:0048609|reproductive process in a multicellular organism, ! single fertilization GO:0007338 75 64 0,000 0,36264957 0,37383671 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,36712436 0,37828746 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,36712436 0,37812552 ! embryonic limb morphogenesis GO:0030326 125 65 0,000 0,36712436 0,37796372 GO:0035113|embryonic appendage morphogenesis, ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,37156789 0,38237482 ! secondary metabolic process GO:0019748 116 66 0,000 0,37156789 0,38221135 ! regulation of cellular response to stress GO:0080135 128 67 0,000 0,37598036 0,38658493 ! cellular hormone metabolic process GO:0034754 113 67 0,000 0,37598036 0,3864198 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,37598036 0,3862548 ! hexose catabolic process GO:0019320 104 67 0,000 0,37598036 0,38608995 ! adaptive immune response GO:0002250 119 67 0,000 0,37598036 0,38592523 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 105 67 0,000 0,37598036 0,38576066 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,38036199 0,39008992 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,38036199 0,38992372 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,38471301 0,39421614 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,38471301 0,39404832 ! antigen processing and presentation GO:0019882 104 69 0,000 0,38471301 0,39388064 ! appendage morphogenesis GO:0035107 135 70 0,000 0,38903361 0,39813478 GO:0035108|limb morphogenesis, ! amine catabolic process GO:0009310 117 71 0,000 0,39332402 0,40235442 ! appendage development GO:0048736 136 71 0,000 0,39332402 0,40218343 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 0,000 0,39332402 0,40201257 ! regulation of MAPKKK cascade GO:0043408 142 71 0,000 0,39332402 0,40184187 ! regulation of immune effector process GO:0002697 137 71 0,000 0,39332402 0,40167131 ! acute inflammatory response GO:0002526 113 72 0,000 0,39758444 0,40584988 ! learning or memory GO:0007611 147 73 0,000 0,40181509 0,40999453 ! regulation of blood pressure GO:0008217 125 73 0,000 0,40181509 0,40982073 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,40181509 0,40964708 ! fertilization GO:0009566 90 73 0,000 0,40181509 0,40947357 ! neurotransmitter transport GO:0006836 123 74 0,000 0,40601616 0,41357954 ! exocytosis GO:0006887 133 74 0,000 0,40601616 0,41340452 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,40601616 0,41322965 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 0,000 0,41018787 0,41729895 ! regulation of vesicle-mediated transport GO:0060627 119 75 0,000 0,41018787 0,41712257 ! rhythmic process GO:0048511 128 75 0,000 0,41018787 0,41694635 ! cytosolic calcium ion homeostasis GO:0051480 135 76 0,000 0,41433041 0,4209793 ! defense response to bacterium GO:0042742 89 76 0,000 0,41433041 0,42080159 ! steroid biosynthetic process GO:0006694 131 76 0,000 0,41433041 0,42062404 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,41433041 0,42044664 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,418444 0,42444193 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,42252883 0,42840471 ! response to steroid hormone stimulus GO:0048545 137 78 0,000 0,42252883 0,42822425 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,42658511 0,43215316 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,42658511 0,43197128 ! activation of protein kinase activity GO:0032147 147 79 0,000 0,42658511 0,43178955 ! response to metal ion GO:0010038 140 80 0,000 0,43061302 0,43568332 ! cellular lipid catabolic process GO:0044242 134 80 0,000 0,43061302 0,43550018 ! digestion GO:0007586 112 81 0,000 0,43461278 0,43936065 ! intracellular protein transmembrane transport GO:0065002 153 81 0,000 0,43461278 0,43917612 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,43858457 0,44300356 ! one-carbon metabolic process GO:0006730 154 85 0,000 0,45033409 0,45468058 ! amine biosynthetic process GO:0009309 138 86 0,000 0,45419595 0,45838736 ! response to inorganic substance GO:0010035 153 86 0,000 0,45419595 0,45819516 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,45419595 0,45800313 ! tube morphogenesis GO:0035239 176 86 0,000 0,45419595 0,45781126 ! alcohol catabolic process GO:0046164 130 86 0,000 0,45419595 0,45761954 ! cellular respiration GO:0045333 135 88 0,000 0,46183886 0,46512528 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,46183886 0,46493066 ! cellular defense response GO:0006968 114 89 0,000 0,46562027 0,46854135 ! sterol metabolic process GO:0016125 152 91 0,000 0,47310394 0,47587294 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,47310394 0,47567408 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,47680656 0,47919657 ! female pregnancy GO:0007565 164 94 0,000 0,48413431 0,48635789 ! transcription initiation GO:0006352 153 94 0,000 0,48413431 0,4861549 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,48775978 0,48959117 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,4913599 0,49299913 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! mRNA transport GO:0051028 169 96 0,000 0,4913599 0,49279363 ! positive regulation of immune response GO:0050778 156 96 0,000 0,4913599 0,4925883 ! detection of stimulus GO:0051606 151 96 0,000 0,4913599 0,49238314 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,49493483 0,49575904 ! hormone metabolic process GO:0042445 157 97 0,000 0,49493483 0,49555273 ! response to virus GO:0009615 160 98 0,000 0,49848476 0,49889947 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,49848476 0,49869203 ! carboxylic acid catabolic process GO:0046395 156 98 0,000 0,49848476 0,49848476 GO:0016054|organic acid catabolic process,