pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6311-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cell migration GO:0030334 71 71 9,000 1,495E-09 2,755E-06 ! regulation of locomotion GO:0040012 79 79 9,000 4,379E-09 4,036E-06 ! regulation of cell motion GO:0051270 79 79 9,000 4,379E-09 2,69E-06 ! regulation of protein stability GO:0031647 19 19 5,000 1,997E-08 9,203E-06 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 3,000 1,124E-06 4,144E-04 ! positive regulation of cell migration GO:0030335 36 36 5,000 1,254E-06 3,852E-04 ! protein stabilization GO:0050821 10 10 3,000 1,86E-06 4,896E-04 ! positive regulation of cell motion GO:0051272 39 39 5,000 2,052E-06 4,726E-04 ! negative regulation of cell migration GO:0030336 26 26 4,000 4,895E-06 1,002E-03 ! regulation of mitotic cell cycle GO:0007346 72 69 6,000 4,934E-06 9,094E-04 ! positive regulation of MAP kinase activity GO:0043406 50 49 5,000 8,128E-06 1,362E-03 ! response to UV GO:0009411 29 29 4,000 8,633E-06 1,326E-03 ! regulation of DNA metabolic process GO:0051052 51 50 5,000 9,163E-06 1,299E-03 ! actin cytoskeleton reorganization GO:0031532 5 5 2,000 9,519E-06 1,253E-03 ! T cell lineage commitment GO:0002360 5 5 2,000 9,519E-06 1,17E-03 ! regulation of DNA replication GO:0006275 32 31 4,000 1,216E-05 1,401E-03 ! negative regulation of cell motion GO:0051271 31 31 4,000 1,216E-05 1,318E-03 ! ER overload response GO:0006983 6 6 2,000 1,89E-05 1,935E-03 ! peptidyl-serine phosphorylation GO:0018105 6 6 2,000 1,89E-05 1,833E-03 ! regulation of binding GO:0051098 60 57 5,000 1,98E-05 1,825E-03 ! response to gamma radiation GO:0010332 8 7 2,000 3,284E-05 2,882E-03 ! cell-matrix adhesion GO:0007160 39 38 4,000 3,403E-05 2,85E-03 ! negative regulation of binding GO:0051100 21 20 3,000 3,978E-05 3,187E-03 ! regulation of MAP kinase activity GO:0043405 67 66 5,000 4,62E-05 3,548E-03 ! posttranscriptional regulation of gene expression GO:0010608 98 98 6,000 5,029E-05 3,707E-03 ! negative regulation of bone remodeling GO:0046851 8 8 2,000 5,216E-05 3,698E-03 ! T cell selection GO:0045058 8 8 2,000 5,216E-05 3,561E-03 ! peptidyl-serine modification GO:0018209 8 8 2,000 5,216E-05 3,434E-03 ! positive regulation of leukocyte migration GO:0002687 8 8 2,000 5,216E-05 3,315E-03 ! release of cytochrome c from mitochondria GO:0001836 9 8 2,000 5,216E-05 3,205E-03 ! cytoplasmic sequestering of protein GO:0051220 8 8 2,000 5,216E-05 3,101E-03 ! response to radiation GO:0009314 70 68 5,000 5,478E-05 3,155E-03 ! cell-substrate adhesion GO:0031589 43 42 4,000 5,59E-05 3,122E-03 ! T cell differentiation in the thymus GO:0033077 9 9 2,000 7,768E-05 4,211E-03 ! negative regulation of tissue remodeling GO:0034104 9 9 2,000 7,768E-05 4,091E-03 ! regulation of leukocyte migration GO:0002685 9 9 2,000 7,768E-05 3,977E-03 ! defense response to virus GO:0051607 9 9 2,000 7,768E-05 3,869E-03 ! T cell differentiation GO:0030217 24 24 3,000 8,464E-05 4,105E-03 ! regulation of intracellular protein transport GO:0033157 25 25 3,000 1E-04 4,726E-03 ! apoptotic mitochondrial changes GO:0008637 11 10 2,000 1,102E-04 5,077E-03 ! regulation of protein binding GO:0043393 11 10 2,000 1,102E-04 4,953E-03 ! negative regulation of homeostatic process GO:0032845 10 10 2,000 1,102E-04 4,835E-03 ! regulation of protein modification process GO:0031399 79 78 5,000 1,188E-04 5,093E-03 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 3,000 1,367E-04 5,724E-03 ! interphase of mitotic cell cycle GO:0051329 52 51 4,000 1,44E-04 5,896E-03 GO:0051325|interphase, ! G1 phase of mitotic cell cycle GO:0000080 12 11 2,000 1,504E-04 6,026E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 2,000 1,504E-04 5,898E-03 GO:0032388|positive regulation of intracellular transport, ! response to light stimulus GO:0009416 53 52 4,000 1,581E-04 6,069E-03 ! protein amino acid autophosphorylation GO:0046777 28 28 3,000 1,582E-04 5,951E-03 ! mitotic chromosome condensation GO:0007076 12 12 2,000 1,991E-04 7,339E-03 ! G1 phase GO:0051318 13 12 2,000 1,991E-04 7,195E-03 ! positive regulation of protein kinase activity GO:0045860 89 86 5,000 2,043E-04 7,24E-03 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 5,000 2,043E-04 7,103E-03 ! regulation of cell adhesion GO:0030155 56 55 4,000 2,067E-04 7,055E-03 ! heart development GO:0007507 90 87 5,000 2,177E-04 7,295E-03 ! positive regulation of transferase activity GO:0051347 91 88 5,000 2,318E-04 7,629E-03 GO:0033674|positive regulation of kinase activity, ! regulation of intracellular transport GO:0032386 31 31 3,000 2,377E-04 7,686E-03 ! regulation of protein localization GO:0032880 58 57 4,000 2,45E-04 7,784E-03 ! negative regulation of protein modification process GO:0031400 13 13 2,000 2,57E-04 8,027E-03 ! mitochondrial membrane organization GO:0007006 13 13 2,000 2,57E-04 7,894E-03 ! negative regulation of DNA replication GO:0008156 13 13 2,000 2,57E-04 7,764E-03 ! negative regulation of protein catabolic process GO:0042177 13 13 2,000 2,57E-04 7,639E-03 ! cell aging GO:0007569 13 13 2,000 2,57E-04 7,518E-03 ! response to endoplasmic reticulum stress GO:0034976 13 13 2,000 2,57E-04 7,4E-03 ! negative regulation of protein kinase cascade GO:0010741 13 13 2,000 2,57E-04 7,286E-03 ! positive regulation of locomotion GO:0040017 13 13 2,000 2,57E-04 7,176E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! regulation of cell-substrate adhesion GO:0010810 14 13 2,000 2,57E-04 7,069E-03 GO:0001952|regulation of cell-matrix adhesion, ! lipid modification GO:0030258 32 32 3,000 2,696E-04 7,308E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 3,000 2,696E-04 7,202E-03 ! negative regulation of cell cycle GO:0045786 92 91 5,000 2,785E-04 7,332E-03 ! peptidyl-amino acid modification GO:0018193 61 59 4,000 2,884E-04 7,486E-03 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 3,247E-04 8,312E-03 ! response to retinoic acid GO:0032526 14 14 2,000 3,247E-04 8,198E-03 GO:0033189|response to vitamin A, ! regulation of behavior GO:0050795 14 14 2,000 3,247E-04 8,087E-03 ! regulation of vasoconstriction GO:0019229 14 14 2,000 3,247E-04 7,98E-03 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 4,000 3,374E-04 8,183E-03 ! regulation of angiogenesis GO:0045765 35 34 3,000 3,425E-04 8,198E-03 ! regulation of protein catabolic process GO:0042176 35 34 3,000 3,425E-04 8,093E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 3,000 3,838E-04 8,954E-03 ! response to vitamin GO:0033273 15 15 2,000 4,03E-04 9,284E-03 ! regulation of transcription factor import into nucleus GO:0042990 15 15 2,000 4,03E-04 9,169E-03 ! ER-nuclear signaling pathway GO:0006984 15 15 2,000 4,03E-04 9,058E-03 ! chromosome condensation GO:0030261 15 15 2,000 4,03E-04 8,948E-03 ! response to ionizing radiation GO:0010212 16 15 2,000 4,03E-04 8,842E-03 ! angiogenesis GO:0001525 65 64 4,000 4,225E-04 9,162E-03 ! integrin-mediated signaling pathway GO:0007229 36 36 3,000 4,285E-04 9,184E-03 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 5,000 4,64E-04 9,83E-03 ! negative regulation of protein metabolic process GO:0051248 66 66 4,000 4,877E-04 0,01021335 ! lymphocyte proliferation GO:0046651 16 16 2,000 4,924E-04 0,01019733 ! fatty acid beta-oxidation GO:0006635 16 16 2,000 4,924E-04 0,01008402 ! Ras protein signal transduction GO:0007265 69 67 4,000 5,229E-04 0,01059093 ! urogenital system development GO:0001655 38 38 3,000 5,29E-04 0,01059668 ! regulation of homeostatic process GO:0032844 38 38 3,000 5,29E-04 0,01048273 ! lymphocyte differentiation GO:0030098 39 39 3,000 5,85E-04 0,01146972 ! cell junction assembly GO:0034329 18 17 2,000 5,937E-04 0,01151732 ! pigmentation GO:0043473 17 17 2,000 5,937E-04 0,01139735 ! response to nutrient levels GO:0031667 69 69 4,000 5,992E-04 0,01138479 ! negative regulation of signal transduction GO:0009968 71 71 4,000 6,835E-04 0,0128545 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 2,000 7,073E-04 0,01316741 ! mononuclear cell proliferation GO:0032943 18 18 2,000 7,073E-04 0,01303574 GO:0070661|leukocyte proliferation, ! negative regulation of DNA binding GO:0043392 19 18 2,000 7,073E-04 0,01290667 ! B cell differentiation GO:0030183 18 18 2,000 7,073E-04 0,01278013 ! negative regulation of catabolic process GO:0009895 18 18 2,000 7,073E-04 0,01265605 ! response to extracellular stimulus GO:0009991 72 72 4,000 7,289E-04 0,01291663 ! DNA damage checkpoint GO:0000077 19 19 2,000 8,339E-04 0,01463728 ! negative regulation of DNA metabolic process GO:0051053 19 19 2,000 8,339E-04 0,01449919 ! reproductive structure development GO:0048608 43 43 3,000 8,517E-04 0,01466964 ! negative regulation of cell communication GO:0010648 76 76 4,000 9,331E-04 0,015924 ! prostate gland development GO:0030850 5 5 1,000 9,722E-04 0,01643843 ! metencephalon development GO:0022037 5 5 1,000 9,722E-04 0,01628899 ! positive regulation of B cell proliferation GO:0030890 5 5 1,000 9,722E-04 0,01614225 ! mRNA stabilization GO:0048255 5 5 1,000 9,722E-04 0,01599812 GO:0043489|RNA stabilization, ! macrophage chemotaxis GO:0048246 6 5 1,000 9,722E-04 0,01585654 ! dopamine receptor signaling pathway GO:0007212 5 5 1,000 9,722E-04 0,01571745 ! thymic T cell selection GO:0045061 5 5 1,000 9,722E-04 0,01558078 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 1,000 9,722E-04 0,01544646 ! phasic smooth muscle contraction GO:0014821 5 5 1,000 9,722E-04 0,01531444 ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 9,722E-04 0,01518465 ! regulation of the force of heart contraction GO:0002026 5 5 1,000 9,722E-04 0,01505705 ! receptor clustering GO:0043113 5 5 1,000 9,722E-04 0,01493158 ! fear response GO:0042596 5 5 1,000 9,722E-04 0,01480818 ! response to UV-B GO:0010224 5 5 1,000 9,722E-04 0,0146868 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 1,000 9,722E-04 0,01456739 ! negative regulation of focal adhesion formation GO:0051895 6 5 1,000 9,722E-04 0,01444991 ! regulation of mitochondrial membrane potential GO:0051881 5 5 1,000 9,722E-04 0,01433431 ! postreplication repair GO:0006301 5 5 1,000 9,722E-04 0,01422055 ! cellular pigmentation GO:0033059 5 5 1,000 9,722E-04 0,01410858 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 1,000 9,722E-04 0,01399835 GO:0002714|positive regulation of B cell mediated immunity, ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 1,000 9,722E-04 0,01388984 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 1,000 9,722E-04 0,01378299 GO:0002820|negative regulation of adaptive immune response, ! peptidyl-lysine modification GO:0018205 5 5 1,000 9,722E-04 0,01367778 ! negative regulation of neuroblast proliferation GO:0007406 5 5 1,000 9,722E-04 0,01357416 ! regulation of isotype switching GO:0045191 5 5 1,000 9,722E-04 0,0134721 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 1,000 9,722E-04 0,01337156 GO:0002688|regulation of leukocyte chemotaxis, ! oocyte differentiation GO:0009994 5 5 1,000 9,722E-04 0,01327251 GO:0048599|oocyte development, ! regulation of protein homodimerization activity GO:0043496 6 5 1,000 9,722E-04 0,01317492 ! spleen development GO:0048536 5 5 1,000 9,722E-04 0,01307875 ! blastocyst formation GO:0001825 5 5 1,000 9,722E-04 0,01298398 ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 1,000 9,722E-04 0,01289057 ! B cell receptor signaling pathway GO:0050853 5 5 1,000 9,722E-04 0,01279849 ! positive regulation of smooth muscle contraction GO:0045987 5 5 1,000 9,722E-04 0,01270773 ! response to nicotine GO:0035094 5 5 1,000 9,722E-04 0,01261823 ! negative regulation of cell adhesion GO:0007162 21 20 2,000 9,741E-04 0,01255383 ! lipid oxidation GO:0034440 20 20 2,000 9,741E-04 0,01246665 GO:0019395|fatty acid oxidation, ! regulation of DNA binding GO:0051101 47 45 3,000 1,013E-03 0,01287413 ! Wnt receptor signaling pathway GO:0016055 46 45 3,000 1,013E-03 0,01278595 ! mitotic sister chromatid segregation GO:0000070 21 21 2,000 1,128E-03 0,0141457 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 2,000 1,128E-03 0,01405012 ! DNA integrity checkpoint GO:0031570 21 21 2,000 1,128E-03 0,01395582 ! regulation of protein import into nucleus GO:0042306 21 21 2,000 1,128E-03 0,01386279 ! negative regulation of protein transport GO:0051224 21 21 2,000 1,128E-03 0,01377098 ! sex differentiation GO:0007548 47 47 3,000 1,194E-03 0,01448253 ! regulation of catabolic process GO:0009894 48 47 3,000 1,194E-03 0,01438787 ! tube development GO:0035295 83 81 4,000 1,245E-03 0,01490095 ! positive regulation of DNA metabolic process GO:0051054 23 22 2,000 1,297E-03 0,0154228 ! sister chromatid segregation GO:0000819 22 22 2,000 1,297E-03 0,01532393 ! cell junction organization GO:0034330 23 22 2,000 1,297E-03 0,01522633 ! maintenance of protein location in cell GO:0032507 23 22 2,000 1,297E-03 0,01512996 ! male sex differentiation GO:0046661 22 22 2,000 1,297E-03 0,0150348 ! fatty acid catabolic process GO:0009062 23 22 2,000 1,297E-03 0,01494083 ! blood vessel morphogenesis GO:0048514 84 83 4,000 1,389E-03 0,0159042 ! leukocyte differentiation GO:0002521 50 49 3,000 1,398E-03 0,01590055 ! gland development GO:0048732 51 49 3,000 1,398E-03 0,01580301 ! response to nutrient GO:0007584 49 49 3,000 1,398E-03 0,01570665 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 1,449E-03 0,01618344 GO:0018409|peptide or protein amino-terminal blocking, ! regulation of S phase GO:0033261 6 6 1,000 1,449E-03 0,01608595 ! regulation of B cell proliferation GO:0030888 6 6 1,000 1,449E-03 0,01598962 ! cartilage condensation GO:0001502 7 6 1,000 1,449E-03 0,01589445 ! regulation of positive chemotaxis GO:0050926 6 6 1,000 1,449E-03 0,0158004 GO:0050927|positive regulation of positive chemotaxis, ! bile acid metabolic process GO:0008206 6 6 1,000 1,449E-03 0,01570745 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 1,000 1,449E-03 0,0156156 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 1,000 1,449E-03 0,01552481 ! positive regulation of heart contraction GO:0045823 6 6 1,000 1,449E-03 0,01543507 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 1,000 1,449E-03 0,01534636 ! inositol phosphate-mediated signaling GO:0048016 6 6 1,000 1,449E-03 0,01525867 ! focal adhesion formation GO:0048041 7 6 1,000 1,449E-03 0,01517197 ! vascular smooth muscle contraction GO:0014829 6 6 1,000 1,449E-03 0,01508625 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 1,449E-03 0,0150015 GO:0070667|negative regulation of mast cell proliferation, ! regulation of heart rate GO:0002027 6 6 1,000 1,449E-03 0,01491769 ! regulation of vascular permeability GO:0043114 6 6 1,000 1,449E-03 0,01483482 ! negative regulation of ossification GO:0030279 6 6 1,000 1,449E-03 0,01475286 ! regulation of bone resorption GO:0045124 6 6 1,000 1,449E-03 0,0146718 ! G1 DNA damage checkpoint GO:0031571 6 6 1,000 1,449E-03 0,01459162 ! positive regulation of T cell mediated immunity GO:0002711 6 6 1,000 1,449E-03 0,01451232 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 1,449E-03 0,01443388 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 1,000 1,449E-03 0,01435627 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 1,449E-03 0,0142795 ! regulation of focal adhesion formation GO:0051893 7 6 1,000 1,449E-03 0,01420355 ! ribosomal large subunit biogenesis GO:0042273 6 6 1,000 1,449E-03 0,0141284 ! thymus development GO:0048538 6 6 1,000 1,449E-03 0,01405404 ! negative regulation of immune effector process GO:0002698 6 6 1,000 1,449E-03 0,01398045 ! localization within membrane GO:0051668 6 6 1,000 1,449E-03 0,01390764 ! mitotic cell cycle checkpoint GO:0007093 24 23 2,000 1,481E-03 0,01414232 ! calcium-mediated signaling GO:0019722 23 23 2,000 1,481E-03 0,01406942 ! T cell activation GO:0042110 51 50 3,000 1,508E-03 0,01425081 ! mitochondrial transport GO:0006839 24 24 2,000 1,68E-03 0,01580157 ! maintenance of protein location GO:0045185 25 24 2,000 1,68E-03 0,01572136 ! epithelial tube morphogenesis GO:0060562 25 24 2,000 1,68E-03 0,01564196 ! response to hypoxia GO:0001666 53 53 3,000 1,874E-03 0,01735977 ! regulation of protein transport GO:0051223 53 53 3,000 1,874E-03 0,01727297 GO:0070201|regulation of establishment of protein localization, ! regulation of T cell proliferation GO:0042129 25 25 2,000 1,896E-03 0,01738462 ! negative regulation of immune system process GO:0002683 25 25 2,000 1,896E-03 0,01729856 ! chemotaxis GO:0006935 90 89 4,000 1,896E-03 0,01721701 GO:0042330|taxis, ! protein amino acid dephosphorylation GO:0006470 55 54 3,000 2,009E-03 0,01815217 ! response to oxygen levels GO:0070482 55 54 3,000 2,009E-03 0,01806362 ! negative regulation of multicellular organismal process GO:0051241 55 54 3,000 2,009E-03 0,01797593 ! positive regulation of GTPase activity GO:0043547 7 7 1,000 2,015E-03 0,01794283 ! hair follicle morphogenesis GO:0031069 7 7 1,000 2,015E-03 0,01785656 ! axis specification GO:0009798 7 7 1,000 2,015E-03 0,01777113 ! digestive system development GO:0055123 7 7 1,000 2,015E-03 0,0176865 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! regulation of skeletal muscle fiber development GO:0048742 7 7 1,000 2,015E-03 0,01760268 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 2,015E-03 0,01751965 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! cardiac muscle tissue development GO:0048738 7 7 1,000 2,015E-03 0,0174374 ! response to X-ray GO:0010165 7 7 1,000 2,015E-03 0,01735591 ! regulation of intracellular pH GO:0051453 7 7 1,000 2,015E-03 0,01727519 ! positive regulation of muscle contraction GO:0045933 7 7 1,000 2,015E-03 0,01719521 ! alpha-beta T cell differentiation GO:0046632 7 7 1,000 2,015E-03 0,01711597 ! axon cargo transport GO:0008088 7 7 1,000 2,015E-03 0,01703745 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 1,000 2,015E-03 0,01695966 GO:0001953|negative regulation of cell-matrix adhesion, ! cAMP biosynthetic process GO:0006171 7 7 1,000 2,015E-03 0,01688257 ! regulation of mRNA stability GO:0043488 7 7 1,000 2,015E-03 0,01680618 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 1,000 2,015E-03 0,01673047 ! T cell receptor signaling pathway GO:0050852 7 7 1,000 2,015E-03 0,01665545 ! negative regulation of T cell activation GO:0050868 7 7 1,000 2,015E-03 0,01658109 ! regulation of T cell differentiation GO:0045580 26 26 2,000 2,128E-03 0,01743063 ! maintenance of location in cell GO:0051651 27 26 2,000 2,128E-03 0,01735351 ! reproductive developmental process GO:0003006 56 56 3,000 2,299E-03 0,01866327 ! peptide metabolic process GO:0006518 29 27 2,000 2,377E-03 0,01921336 ! blood vessel development GO:0001568 95 94 4,000 2,413E-03 0,01942027 ! epidermis development GO:0008544 94 94 4,000 2,413E-03 0,01933584 ! regulation of mast cell proliferation GO:0070666 28 28 2,000 2,643E-03 0,02108801 ! vasculature development GO:0001944 97 96 4,000 2,646E-03 0,02101951 ! regulation of cell growth GO:0001558 97 96 4,000 2,646E-03 0,0209293 ! regulation of skeletal muscle tissue development GO:0048641 8 8 1,000 2,67E-03 0,02102639 ! positive regulation of cell killing GO:0031343 8 8 1,000 2,67E-03 0,02093691 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 1,000 2,67E-03 0,0208482 ! cell-cell junction assembly GO:0007043 8 8 1,000 2,67E-03 0,02076023 ! positive regulation of endothelial cell migration GO:0010595 8 8 1,000 2,67E-03 0,020673 ! sex determination GO:0007530 8 8 1,000 2,67E-03 0,0205865 ! negative regulation of mitotic cell cycle GO:0045930 9 8 1,000 2,67E-03 0,02050073 ! plasma membrane fusion GO:0045026 8 8 1,000 2,67E-03 0,02041566 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 1,000 2,67E-03 0,0203313 ! alpha-beta T cell activation GO:0046631 8 8 1,000 2,67E-03 0,02024763 ! vasoconstriction GO:0042310 8 8 1,000 2,67E-03 0,02016465 ! regulation of T cell mediated immunity GO:0002709 8 8 1,000 2,67E-03 0,02008234 ! T cell homeostasis GO:0043029 8 8 1,000 2,67E-03 0,02000071 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 1,000 2,67E-03 0,01991973 ! regulation of immunoglobulin production GO:0002637 8 8 1,000 2,67E-03 0,01983941 ! regulation of RNA stability GO:0043487 8 8 1,000 2,67E-03 0,01975974 ! dephosphorylation GO:0016311 60 59 3,000 2,785E-03 0,0205314 ! regulation of epithelial cell proliferation GO:0050678 29 29 2,000 2,927E-03 0,02149271 ! regulation of lymphocyte proliferation GO:0050670 29 29 2,000 2,927E-03 0,02140742 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! positive regulation of protein transport GO:0051222 29 29 2,000 2,927E-03 0,02132281 ! ectoderm development GO:0007398 99 99 4,000 3,025E-03 0,02195221 ! hemopoiesis GO:0030097 104 100 4,000 3,16E-03 0,02284046 ! positive regulation of response to external stimulus GO:0032103 30 30 2,000 3,229E-03 0,0232475 ! vascular process in circulatory system GO:0003018 31 30 2,000 3,229E-03 0,02315704 ! positive regulation of cell projection organization GO:0031346 9 9 1,000 3,41E-03 0,02436059 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 1,000 3,41E-03 0,02426653 ! regulation of cell-cell adhesion GO:0022407 9 9 1,000 3,41E-03 0,0241732 ! response to alkaloid GO:0043279 10 9 1,000 3,41E-03 0,02408058 ! positive regulation of endothelial cell proliferation GO:0001938 9 9 1,000 3,41E-03 0,02398867 ! response to ethanol GO:0045471 9 9 1,000 3,41E-03 0,02389746 ! activation of pro-apoptotic gene products GO:0008633 9 9 1,000 3,41E-03 0,02380694 ! pigmentation during development GO:0048066 9 9 1,000 3,41E-03 0,0237171 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 3,41E-03 0,02362794 GO:0060675|ureteric bud morphogenesis, ! negative regulation of protein import into nucleus GO:0042308 9 9 1,000 3,41E-03 0,02353945 ! positive regulation of protein import into nucleus GO:0042307 9 9 1,000 3,41E-03 0,02345161 ! DNA replication initiation GO:0006270 9 9 1,000 3,41E-03 0,02336443 ! regulation of cellular pH GO:0030641 9 9 1,000 3,41E-03 0,0232779 ! histone acetylation GO:0016573 9 9 1,000 3,41E-03 0,023192 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 1,000 3,41E-03 0,02310674 GO:0002712|regulation of B cell mediated immunity, ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 1,000 3,41E-03 0,0230221 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 1,000 3,41E-03 0,02293807 ! membrane fusion GO:0006944 31 31 2,000 3,55E-03 0,02378933 ! B cell activation GO:0042113 31 31 2,000 3,55E-03 0,02370314 ! aging GO:0007568 32 31 2,000 3,55E-03 0,02361756 ! negative regulation of cell growth GO:0030308 32 32 2,000 3,889E-03 0,0257821 ! regulation of lymphocyte differentiation GO:0045619 32 32 2,000 3,889E-03 0,0256897 ! maintenance of location GO:0051235 33 32 2,000 3,889E-03 0,02559795 ! regulation of protein ubiquitination GO:0031396 10 10 1,000 4,235E-03 0,02777767 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 1,000 4,235E-03 0,02767917 ! regulation of cell killing GO:0031341 10 10 1,000 4,235E-03 0,02758136 ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 1,000 4,235E-03 0,02748424 ! inositol metabolic process GO:0006020 10 10 1,000 4,235E-03 0,02738781 ! cAMP metabolic process GO:0046058 10 10 1,000 4,235E-03 0,02729205 ! epidermis morphogenesis GO:0048730 10 10 1,000 4,235E-03 0,02719695 ! cell-substrate junction assembly GO:0007044 11 10 1,000 4,235E-03 0,02710252 ! neuromuscular junction development GO:0007528 10 10 1,000 4,235E-03 0,02700874 ! intermediate filament cytoskeleton organization GO:0045104 10 10 1,000 4,235E-03 0,0269156 ! negative regulation of immune response GO:0050777 10 10 1,000 4,235E-03 0,02682311 ! regulation of B cell differentiation GO:0045577 10 10 1,000 4,235E-03 0,02673125 ! gland morphogenesis GO:0022612 10 10 1,000 4,235E-03 0,02664002 ! lymphocyte homeostasis GO:0002260 10 10 1,000 4,235E-03 0,0265494 ! gut development GO:0048565 10 10 1,000 4,235E-03 0,02645941 ! positive regulation of neuron apoptosis GO:0043525 10 10 1,000 4,235E-03 0,02637002 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 1,000 4,235E-03 0,02628123 ! negative regulation of cell size GO:0045792 33 33 2,000 4,247E-03 0,02626861 ! regulation of neuron apoptosis GO:0043523 34 33 2,000 4,247E-03 0,02618076 ! striated muscle tissue development GO:0014706 69 67 3,000 4,417E-03 0,02713737 ! regulation of bone remodeling GO:0046850 34 34 2,000 4,625E-03 0,02832063 ! regulation of cell size GO:0008361 68 68 3,000 4,658E-03 0,02842887 ! mesoderm development GO:0007498 35 35 2,000 5,023E-03 0,03055237 ! regulation of tissue remodeling GO:0034103 35 35 2,000 5,023E-03 0,03045187 ! signal complex assembly GO:0007172 11 11 1,000 5,143E-03 0,031077 ! microtubule-based transport GO:0010970 11 11 1,000 5,143E-03 0,03097544 ! endothelial cell migration GO:0043542 11 11 1,000 5,143E-03 0,03087454 ! protein amino acid acetylation GO:0006473 11 11 1,000 5,143E-03 0,0307743 ! T cell proliferation GO:0042098 11 11 1,000 5,143E-03 0,03067471 ! regulation of transmembrane transporter activity GO:0022898 11 11 1,000 5,143E-03 0,03057576 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! regulation of viral genome replication GO:0045069 11 11 1,000 5,143E-03 0,03047744 ! smooth muscle contraction GO:0006939 11 11 1,000 5,143E-03 0,03037976 ! cellular response to starvation GO:0009267 11 11 1,000 5,143E-03 0,0302827 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 1,000 5,143E-03 0,03018626 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 1,000 5,143E-03 0,03009043 ! G1/S transition checkpoint GO:0031575 12 11 1,000 5,143E-03 0,02999521 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 1,000 5,143E-03 0,02990058 ! intermediate filament-based process GO:0045103 11 11 1,000 5,143E-03 0,02980656 ! regulation of monooxygenase activity GO:0032768 11 11 1,000 5,143E-03 0,02971312 ! oogenesis GO:0048477 11 11 1,000 5,143E-03 0,02962027 ! negative regulation of angiogenesis GO:0016525 11 11 1,000 5,143E-03 0,02952799 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 1,000 5,143E-03 0,02943629 ! hindbrain development GO:0030902 11 11 1,000 5,143E-03 0,02934516 ! endocrine process GO:0050886 11 11 1,000 5,143E-03 0,02925458 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 5,143E-03 0,02916457 ! muscle tissue development GO:0060537 72 70 3,000 5,167E-03 0,02921048 ! calcium ion homeostasis GO:0055074 71 71 3,000 5,435E-03 0,03062973 GO:0006874|cellular calcium ion homeostasis, ! female pregnancy GO:0007565 37 36 2,000 5,441E-03 0,03057057 ! gonad development GO:0008406 36 36 2,000 5,441E-03 0,03047765 ! positive regulation of hydrolase activity GO:0051345 72 72 3,000 5,711E-03 0,03189719 ! regulation of transcription factor activity GO:0051090 38 37 2,000 5,879E-03 0,03273217 GO:0090046|regulation of transcription regulator activity, ! negative regulation of protein kinase activity GO:0006469 37 37 2,000 5,879E-03 0,03263358 ! response to drug GO:0042493 37 37 2,000 5,879E-03 0,03253558 ! lung development GO:0030324 38 37 2,000 5,879E-03 0,03243817 ! negative regulation of growth GO:0045926 37 37 2,000 5,879E-03 0,03234134 ! DNA damage response, signal transduction GO:0042770 37 37 2,000 5,879E-03 0,03224508 ! C21-steroid hormone metabolic process GO:0008207 13 12 1,000 6,132E-03 0,03353351 ! vesicle docking during exocytosis GO:0006904 12 12 1,000 6,132E-03 0,03343429 ! male gonad development GO:0008584 12 12 1,000 6,132E-03 0,03333567 ! regulation of alpha-beta T cell activation GO:0046634 12 12 1,000 6,132E-03 0,03323762 ! renal system process GO:0003014 12 12 1,000 6,132E-03 0,03314015 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 1,000 6,132E-03 0,03304325 ! positive regulation of multicellular organism growth GO:0040018 12 12 1,000 6,132E-03 0,03294691 ! somitogenesis GO:0001756 13 12 1,000 6,132E-03 0,03285114 ! positive regulation of adaptive immune response GO:0002821 12 12 1,000 6,132E-03 0,03275592 ! neural tube closure GO:0001843 13 12 1,000 6,132E-03 0,03266125 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 1,000 6,132E-03 0,03256712 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 1,000 6,132E-03 0,03247354 ! exocytosis GO:0006887 40 38 2,000 6,337E-03 0,03346546 ! negative regulation of kinase activity GO:0033673 38 38 2,000 6,337E-03 0,03336984 ! chromosome segregation GO:0007059 38 38 2,000 6,337E-03 0,03327477 ! activation of MAPK activity GO:0000187 39 39 2,000 6,817E-03 0,03569001 ! respiratory tube development GO:0030323 40 39 2,000 6,817E-03 0,03558891 ! cytokine-mediated signaling pathway GO:0019221 39 39 2,000 6,817E-03 0,03548838 ! regulation of MAPKKK cascade GO:0043408 41 39 2,000 6,817E-03 0,03538841 ! respiratory system development GO:0060541 40 39 2,000 6,817E-03 0,035289 ! positive regulation of DNA replication GO:0045740 14 13 1,000 7,2E-03 0,0371691 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 1,000 7,2E-03 0,03706528 ! G2/M transition of mitotic cell cycle GO:0000086 13 13 1,000 7,2E-03 0,03696203 ! regeneration GO:0031099 13 13 1,000 7,2E-03 0,03685936 ! post-embryonic development GO:0009791 14 13 1,000 7,2E-03 0,03675725 ! vasculogenesis GO:0001570 13 13 1,000 7,2E-03 0,03665571 ! regulation of DNA recombination GO:0000018 13 13 1,000 7,2E-03 0,03655473 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 1,000 7,2E-03 0,03645431 ! response to corticosteroid stimulus GO:0031960 13 13 1,000 7,2E-03 0,03635443 GO:0051384|response to glucocorticoid stimulus, ! receptor metabolic process GO:0043112 14 13 1,000 7,2E-03 0,03625511 ! ureteric bud development GO:0001657 13 13 1,000 7,2E-03 0,03615632 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 1,000 7,2E-03 0,03605807 ! regulation of endothelial cell migration GO:0010594 13 13 1,000 7,2E-03 0,03596035 ! regulation of viral reproduction GO:0050792 13 13 1,000 7,2E-03 0,03586316 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 1,000 7,2E-03 0,03576649 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 1,000 7,2E-03 0,03567035 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 1,000 7,2E-03 0,03557471 ! neutrophil chemotaxis GO:0030593 14 13 1,000 7,2E-03 0,0354796 ! immunoglobulin production GO:0002377 13 13 1,000 7,2E-03 0,03538498 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 1,000 7,2E-03 0,03529087 ! negative regulation of intracellular transport GO:0032387 13 13 1,000 7,2E-03 0,03519726 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 7,2E-03 0,03510415 ! cell-cell junction organization GO:0045216 13 13 1,000 7,2E-03 0,03501153 ! response to cytokine stimulus GO:0034097 13 13 1,000 7,2E-03 0,03491939 ! activation of JUN kinase activity GO:0007257 13 13 1,000 7,2E-03 0,03482774 ! blastocyst development GO:0001824 13 13 1,000 7,2E-03 0,03473657 ! tissue homeostasis GO:0001894 13 13 1,000 7,2E-03 0,03464587 GO:0048871|multicellular organismal homeostasis, ! protein tetramerization GO:0051262 13 13 1,000 7,2E-03 0,03455565 ! cellular metal ion homeostasis GO:0006875 77 77 3,000 7,237E-03 0,0346447 ! negative regulation of transferase activity GO:0051348 40 40 2,000 7,317E-03 0,03493548 ! metal ion homeostasis GO:0055065 78 78 3,000 7,572E-03 0,03605839 ! cell cycle checkpoint GO:0000075 42 41 2,000 7,839E-03 0,03723319 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 2,000 7,839E-03 0,03713747 ! nuclear transport GO:0051169 79 79 3,000 7,916E-03 0,037409 GO:0006913|nucleocytoplasmic transport, ! neuron projection development GO:0031175 85 80 3,000 8,271E-03 0,03898512 ! protein amino acid acylation GO:0043543 14 14 1,000 8,346E-03 0,03923772 ! vesicle docking GO:0048278 14 14 1,000 8,346E-03 0,03913788 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 1,000 8,346E-03 0,03903854 ! hair cycle GO:0042633 14 14 1,000 8,346E-03 0,03893971 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 1,000 8,346E-03 0,03884138 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! multicellular organismal response to stress GO:0033555 14 14 1,000 8,346E-03 0,03874354 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 1,000 8,346E-03 0,0386462 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 1,000 8,346E-03 0,03854934 ! primary neural tube formation GO:0014020 15 14 1,000 8,346E-03 0,03845297 ! base-excision repair GO:0006284 14 14 1,000 8,346E-03 0,03835707 ! response to organic cyclic substance GO:0014070 15 14 1,000 8,346E-03 0,03826166 ! cytosolic calcium ion homeostasis GO:0051480 42 42 2,000 8,382E-03 0,03833103 ! development of primary sexual characteristics GO:0045137 42 42 2,000 8,382E-03 0,03823615 ! lymphocyte activation GO:0046649 82 81 3,000 8,636E-03 0,03929834 ! lipid catabolic process GO:0016042 82 81 3,000 8,636E-03 0,03920154 ! mitochondrion organization GO:0007005 44 43 2,000 8,946E-03 0,04051164 ! protein import into nucleus GO:0006606 44 44 2,000 9,533E-03 0,04306202 ! protein import into nucleus, translocation GO:0000060 15 15 1,000 9,568E-03 0,0431131 ! ovarian follicle development GO:0001541 15 15 1,000 9,568E-03 0,04300795 ! regulation of smooth muscle contraction GO:0006940 15 15 1,000 9,568E-03 0,04290331 ! response to starvation GO:0042594 15 15 1,000 9,568E-03 0,04279917 ! regulation of production of molecular mediator of immune response GO:0002700 15 15 1,000 9,568E-03 0,04269554 ! cyclic nucleotide biosynthetic process GO:0009190 15 15 1,000 9,568E-03 0,04259241 ! leukocyte homeostasis GO:0001776 15 15 1,000 9,568E-03 0,04248978 ! glutathione metabolic process GO:0006749 16 15 1,000 9,568E-03 0,04238764 ! positive regulation of B cell activation GO:0050871 15 15 1,000 9,568E-03 0,04228599 ! negative regulation of transcription factor activity GO:0043433 16 15 1,000 9,568E-03 0,04218483 GO:0090048|negative regulation of transcription regulator activity, ! negative regulation of cell activation GO:0050866 15 15 1,000 9,568E-03 0,04208415 ! positive regulation of immune effector process GO:0002699 15 15 1,000 9,568E-03 0,04198395 ! phosphoinositide-mediated signaling GO:0048015 45 45 2,000 0,01014157 0,04439647 ! nuclear import GO:0051170 45 45 2,000 0,01014157 0,04429127 ! regulation of cellular localization GO:0060341 86 85 3,000 0,010201 0,04444551 ! positive regulation of response to stimulus GO:0048584 86 85 3,000 0,010201 0,04434069 ! tube morphogenesis GO:0035239 47 46 2,000 0,01077231 0,04671379 ! regulation of membrane potential GO:0042391 46 46 2,000 0,01077231 0,04660413 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 1,000 0,01086416 0,04689144 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 1,000 0,01086416 0,04678188 ! segmentation GO:0035282 17 16 1,000 0,01086416 0,04667283 ! positive regulation of cell development GO:0010720 16 16 1,000 0,01086416 0,04656429 ! regulation of systemic arterial blood pressure GO:0003073 17 16 1,000 0,01086416 0,04645625 ! positive regulation of MAPKKK cascade GO:0043410 17 16 1,000 0,01086416 0,04634871 ! cellular response to nutrient levels GO:0031669 16 16 1,000 0,01086416 0,04624167 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 1,000 0,01086416 0,04613512 ! polyol metabolic process GO:0019751 16 16 1,000 0,01086416 0,04602907 ! embryonic epithelial tube formation GO:0001838 17 16 1,000 0,01086416 0,04592349 GO:0001841|neural tube formation, ! regulation of JUN kinase activity GO:0043506 17 16 1,000 0,01086416 0,04581841 GO:0043507|positive regulation of JUN kinase activity, ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 3,000 0,01193994 0,05024044 ! actin filament organization GO:0007015 50 48 2,000 0,01210081 0,05080137 ! regulation of cell cycle process GO:0010564 50 48 2,000 0,01210081 0,05068591 ! protein localization in nucleus GO:0034504 48 48 2,000 0,01210081 0,05057098 ! regulation of fibroblast proliferation GO:0048145 17 17 1,000 0,01223356 0,05101005 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 1,000 0,01223356 0,05089491 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 0,01223356 0,05078028 ! myelination GO:0042552 17 17 1,000 0,01223356 0,05066617 ! regulation of transmembrane transport GO:0034762 17 17 1,000 0,01223356 0,05055256 ! leukocyte adhesion GO:0007159 17 17 1,000 0,01223356 0,05043947 ! tissue remodeling GO:0048771 17 17 1,000 0,01223356 0,05032688 ! development of primary male sexual characteristics GO:0046546 17 17 1,000 0,01223356 0,0502148 ! response to toxin GO:0009636 18 17 1,000 0,01223356 0,05010321 ! negative regulation of cell development GO:0010721 18 17 1,000 0,01223356 0,04999211 GO:0050768|negative regulation of neurogenesis, ! immune response-activating signal transduction GO:0002757 17 17 1,000 0,01223356 0,04988151 GO:0002764|immune response-regulating signal transduction, ! regulation of oxidoreductase activity GO:0051341 17 17 1,000 0,01223356 0,0497714 ! myeloid leukocyte activation GO:0002274 18 17 1,000 0,01223356 0,04966177 ! ossification GO:0001503 50 49 2,000 0,01279885 0,05184236 GO:0060348|bone development, ! cell cycle arrest GO:0007050 49 49 2,000 0,01279885 0,05172867 ! cellular lipid catabolic process GO:0044242 50 49 2,000 0,01279885 0,05161548 ! skeletal muscle tissue development GO:0007519 50 49 2,000 0,01279885 0,05150278 GO:0060538|skeletal muscle organ development, ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 3,000 0,01287666 0,051703 ! DNA replication GO:0006260 91 91 3,000 0,01287666 0,0515906 ! positive regulation of immune system process GO:0002684 92 92 3,000 0,01336217 0,05341968 ! negative regulation of transport GO:0051051 51 50 2,000 0,01351955 0,05393189 ! regulation of neurogenesis GO:0050767 51 50 2,000 0,01351955 0,0538154 ! regulation of cell projection organization GO:0031344 19 18 1,000 0,01367434 0,05431423 ! membrane docking GO:0022406 18 18 1,000 0,01367434 0,05419742 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 1,000 0,01367434 0,05408112 ! cellular response to extracellular stimulus GO:0031668 18 18 1,000 0,01367434 0,05396532 ! ensheathment of neurons GO:0007272 18 18 1,000 0,01367434 0,05385 GO:0008366|axon ensheathment, ! regulation of microtubule-based process GO:0032886 18 18 1,000 0,01367434 0,05373519 ! cell fate commitment GO:0045165 52 52 2,000 0,01502938 0,05893434 ! regulation of GTPase activity GO:0043087 53 52 2,000 0,01502938 0,05880921 ! regulation of pH GO:0006885 19 19 1,000 0,01518497 0,05929218 ! regulation of endothelial cell proliferation GO:0001936 19 19 1,000 0,01518497 0,05916682 ! positive regulation of T cell proliferation GO:0042102 19 19 1,000 0,01518497 0,059042 ! regulation of striated muscle tissue development GO:0016202 20 19 1,000 0,01518497 0,0589177 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 0,01518497 0,05879392 ! metanephros development GO:0001656 19 19 1,000 0,01518497 0,05867066 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 1,000 0,01518497 0,05854792 ! positive regulation of T cell differentiation GO:0045582 19 19 1,000 0,01518497 0,05842569 ! peripheral nervous system development GO:0007422 19 19 1,000 0,01518497 0,05830397 ! hormone biosynthetic process GO:0042446 19 19 1,000 0,01518497 0,05818276 ! dorsal/ventral pattern formation GO:0009953 19 19 1,000 0,01518497 0,05806205 ! regulation of cell shape GO:0008360 21 19 1,000 0,01518497 0,05794184 ! response to heat GO:0009408 19 19 1,000 0,01518497 0,05782212 ! regulation of T cell activation GO:0050863 53 53 2,000 0,01581867 0,06011095 ! blood circulation GO:0008015 99 98 3,000 0,01652105 0,06265082 GO:0003013|circulatory system process, ! response to virus GO:0009615 54 54 2,000 0,01663099 0,06293822 ! regulation of muscle development GO:0048634 21 20 1,000 0,01676396 0,06331145 ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 1,000 0,01676396 0,06318197 ! neural tube development GO:0021915 21 20 1,000 0,01676396 0,06305303 ! positive regulation of gene-specific transcription GO:0043193 20 20 1,000 0,01676396 0,06292461 ! cyclic nucleotide metabolic process GO:0009187 20 20 1,000 0,01676396 0,06279672 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 0,01676396 0,06266934 ! female gamete generation GO:0007292 20 20 1,000 0,01676396 0,06254248 ! negative regulation of neuron apoptosis GO:0043524 21 20 1,000 0,01676396 0,06241613 ! regulation of B cell activation GO:0050864 20 20 1,000 0,01676396 0,06229029 ! in utero embryonic development GO:0001701 55 55 2,000 0,0174664 0,06476975 ! muscle organ development GO:0007517 102 100 3,000 0,01766967 0,06539195 ! regulation of nervous system development GO:0051960 57 56 2,000 0,01832494 0,0676811 ! mammary gland development GO:0030879 23 21 1,000 0,01840983 0,06785862 ! Notch signaling pathway GO:0007219 22 21 1,000 0,01840983 0,06772317 ! morphogenesis of embryonic epithelium GO:0016331 22 21 1,000 0,01840983 0,06758826 ! regulation of leukocyte mediated immunity GO:0002703 21 21 1,000 0,01840983 0,06745389 ! regulation of action potential in neuron GO:0019228 21 21 1,000 0,01840983 0,06732006 ! regulation of multicellular organism growth GO:0040014 21 21 1,000 0,01840983 0,06718675 ! negative regulation of hydrolase activity GO:0051346 21 21 1,000 0,01840983 0,06705397 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 1,000 0,01840983 0,06692171 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 0,0201211 0,0729984 GO:0090047|positive regulation of transcription regulator activity, ! positive regulation of lymphocyte proliferation GO:0050671 22 22 1,000 0,0201211 0,07285498 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! ovulation cycle process GO:0022602 22 22 1,000 0,0201211 0,07271213 ! cell chemotaxis GO:0060326 23 22 1,000 0,0201211 0,07256984 GO:0030595|leukocyte chemotaxis, ! regulation of adaptive immune response GO:0002819 22 22 1,000 0,0201211 0,0724281 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 1,000 0,0201211 0,07228691 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 1,000 0,0201211 0,07214628 ! regulation of cell development GO:0060284 60 59 2,000 0,02103984 0,07529405 ! protein localization in organelle GO:0033365 59 59 2,000 0,02103984 0,07514813 ! immune effector process GO:0002252 59 59 2,000 0,02103984 0,07500277 ! response to hydrogen peroxide GO:0042542 24 23 1,000 0,02189635 0,07790535 ! response to estrogen stimulus GO:0043627 23 23 1,000 0,02189635 0,07775524 ! positive regulation of growth GO:0045927 23 23 1,000 0,02189635 0,07760571 ! female gonad development GO:0008585 23 23 1,000 0,02189635 0,07745675 ! monovalent inorganic cation homeostasis GO:0055067 23 23 1,000 0,02189635 0,07730837 ! Rho protein signal transduction GO:0007266 24 23 1,000 0,02189635 0,07716055 ! regulation of JNK cascade GO:0046328 25 23 1,000 0,02189635 0,0770133 ! cell projection assembly GO:0030031 25 23 1,000 0,02189635 0,07686661 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 2,000 0,02199133 0,07705326 ! carboxylic acid catabolic process GO:0046395 63 61 2,000 0,02296609 0,08031596 GO:0016054|organic acid catabolic process, ! regulation of action potential GO:0001508 24 24 1,000 0,02373415 0,08284479 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 1,000 0,02373415 0,08268818 ! ovulation cycle GO:0042698 24 24 1,000 0,02373415 0,08253216 ! androgen receptor signaling pathway GO:0030521 24 24 1,000 0,02373415 0,08237674 ! glucan metabolic process GO:0044042 25 24 1,000 0,02373415 0,08222189 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! morphogenesis of an epithelium GO:0002009 63 62 2,000 0,02396415 0,0828629 GO:0060429|epithelium development, ! axonogenesis GO:0007409 66 62 2,000 0,02396415 0,08270772 ! regulation of cellular component biogenesis GO:0044087 63 62 2,000 0,02396415 0,08255313 ! protein import GO:0017038 62 62 2,000 0,02396415 0,08239911 ! regulation of lymphocyte activation GO:0051249 62 62 2,000 0,02396415 0,08224567 ! regulation of gene-specific transcription GO:0032583 25 25 1,000 0,02563313 0,08781013 ! endosome transport GO:0016197 25 25 1,000 0,02563313 0,08764722 ! development of primary female sexual characteristics GO:0046545 25 25 1,000 0,02563313 0,08748491 GO:0046660|female sex differentiation, ! positive regulation of DNA binding GO:0043388 26 25 1,000 0,02563313 0,0873232 ! regulation of endocytosis GO:0030100 25 25 1,000 0,02563313 0,08716209 ! regulation of response to external stimulus GO:0032101 65 64 2,000 0,0260301 0,08834894 ! positive regulation of binding GO:0051099 27 26 1,000 0,02759189 0,09347766 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 1,000 0,02759189 0,09330614 ! induction of apoptosis by intracellular signals GO:0008629 26 26 1,000 0,02759189 0,09313525 ! double-strand break repair GO:0006302 27 26 1,000 0,02759189 0,09296499 ! germ cell development GO:0007281 27 26 1,000 0,02759189 0,09279534 ! regulation of blood vessel size GO:0050880 27 26 1,000 0,02759189 0,09262632 GO:0035150|regulation of tube size, ! pigment metabolic process GO:0042440 26 26 1,000 0,02759189 0,0924579 ! synapse organization GO:0050808 26 26 1,000 0,02759189 0,0922901 ! DNA packaging GO:0006323 66 66 2,000 0,02818907 0,09411677 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 2,000 0,02930337 0,09766024 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! energy reserve metabolic process GO:0006112 28 27 1,000 0,02960908 0,09850098 ! cAMP-mediated signaling GO:0019933 27 27 1,000 0,02960908 0,0983235 ! activation of caspase activity GO:0006919 27 27 1,000 0,02960908 0,09814666 ! mesenchymal cell development GO:0014031 29 27 1,000 0,02960908 0,09797045 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! cell growth GO:0016049 27 27 1,000 0,02960908 0,09779488 ! regionalization GO:0003002 70 69 2,000 0,0316014 0,10418852 ! regulation of leukocyte activation GO:0002694 69 69 2,000 0,0316014 0,10400246 ! stress-activated protein kinase signaling pathway GO:0031098 28 28 1,000 0,03168339 0,10408642 GO:0007254|JNK cascade, ! regulation of muscle contraction GO:0006937 28 28 1,000 0,03168339 0,10390121 ! histone modification GO:0016570 28 28 1,000 0,03168339 0,10371667 ! developmental growth GO:0048589 28 28 1,000 0,03168339 0,10353277 ! cartilage development GO:0051216 29 28 1,000 0,03168339 0,10334953 ! positive regulation of transport GO:0051050 71 70 2,000 0,03278503 0,10675409 ! cell part morphogenesis GO:0032990 75 70 2,000 0,03278503 0,10656582 ! growth GO:0040007 70 70 2,000 0,03278503 0,1063782 ! positive regulation of cell cycle GO:0045787 29 29 1,000 0,03381348 0,1095224 ! phosphoinositide metabolic process GO:0030384 29 29 1,000 0,03381348 0,10933026 ! leukocyte migration GO:0050900 30 29 1,000 0,03381348 0,10913879 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 0,03381348 0,10894798 ! DNA-dependent DNA replication GO:0006261 29 29 1,000 0,03381348 0,10875785 ! covalent chromatin modification GO:0016569 29 29 1,000 0,03381348 0,10856837 ! ribosome biogenesis GO:0042254 71 71 2,000 0,03399167 0,1089507 ! regulation of cell activation GO:0050865 71 71 2,000 0,03399167 0,10876155 ! secretion by cell GO:0032940 75 72 2,000 0,03522125 0,11250046 ! response to reactive oxygen species GO:0000302 31 30 1,000 0,03599808 0,11478279 ! positive regulation of peptidase activity GO:0010952 30 30 1,000 0,03599808 0,11458455 GO:0043280|positive regulation of caspase activity, ! activation of phospholipase C activity GO:0007202 30 30 1,000 0,03599808 0,11438699 GO:0010863|positive regulation of phospholipase C activity, ! skeletal system morphogenesis GO:0048705 31 30 1,000 0,03599808 0,11419011 ! response to temperature stimulus GO:0009266 30 30 1,000 0,03599808 0,1139939 ! regulation of ossification GO:0030278 30 30 1,000 0,03599808 0,11379837 ! vesicle organization GO:0016050 30 30 1,000 0,03599808 0,11360351 ! skeletal muscle fiber development GO:0048741 31 31 1,000 0,0382359 0,12045941 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 0,0382359 0,12025385 ! regulation of heart contraction GO:0008016 31 31 1,000 0,0382359 0,12004899 ! positive regulation of multicellular organismal process GO:0051240 76 76 2,000 0,04036748 0,12652596 ! muscle fiber development GO:0048747 32 32 1,000 0,04052569 0,12680619 ! regulation of phospholipase activity GO:0010517 32 32 1,000 0,04052569 0,12659126 ! regulation of vesicle-mediated transport GO:0060627 33 32 1,000 0,04052569 0,12637706 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 0,04052569 0,12616359 ! nuclear export GO:0051168 32 32 1,000 0,04052569 0,12595083 ! kidney development GO:0001822 32 32 1,000 0,04052569 0,12573879 ! positive regulation of lipase activity GO:0060193 32 32 1,000 0,04052569 0,12552747 ! cell morphogenesis involved in differentiation GO:0000904 82 77 2,000 0,0417106 0,12898092 ! regulation of cellular response to stress GO:0080135 35 33 1,000 0,04286622 0,1323324 ! regulation of neuron differentiation GO:0045664 34 33 1,000 0,04286622 0,13211111 ! microtubule-based movement GO:0007018 82 78 2,000 0,04307615 0,13253648 ! positive regulation of protein kinase cascade GO:0010740 79 78 2,000 0,04307615 0,13231559 ! response to metal ion GO:0010038 34 34 1,000 0,04525627 0,13878089 ! ear development GO:0043583 34 34 1,000 0,04525627 0,13855036 ! cellular polysaccharide metabolic process GO:0044264 35 34 1,000 0,04525627 0,13832059 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 1,000 0,04525627 0,13809158 ! secondary metabolic process GO:0019748 34 34 1,000 0,04525627 0,13786333 ! response to peptide hormone stimulus GO:0043434 36 34 1,000 0,04525627 0,13763583 ! negative regulation of response to stimulus GO:0048585 34 34 1,000 0,04525627 0,13740908 ! MAPKKK cascade GO:0000165 82 81 2,000 0,04730642 0,14339758 ! multicellular organism reproduction GO:0032504 36 35 1,000 0,04769466 0,14433703 GO:0048609|reproductive process in a multicellular organism, ! regulation of cell morphogenesis GO:0022604 38 35 1,000 0,04769466 0,14410041 ! positive regulation of phosphorylation GO:0042327 35 35 1,000 0,04769466 0,14386457 ! response to steroid hormone stimulus GO:0048545 35 35 1,000 0,04769466 0,14362949 ! regulation of immune effector process GO:0002697 35 35 1,000 0,04769466 0,14339519 ! rRNA transcription GO:0009303 5 5 0,000 0,04916357 0,14757078 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,04916357 0,14733083 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,04916357 0,14709166 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,04916357 0,14685326 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,04916357 0,14661563 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,04916357 0,14637877 ! reproductive cellular process GO:0048610 5 5 0,000 0,04916357 0,14614268 ! positive regulation of glucose metabolic process GO:0010907 5 5 0,000 0,04916357 0,14590734 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,04916357 0,14567277 ! water transport GO:0006833 5 5 0,000 0,04916357 0,14543894 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,04916357 0,14520587 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,04916357 0,14497354 ! glycerol metabolic process GO:0006071 5 5 0,000 0,04916357 0,14474195 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,04916357 0,1445111 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,04916357 0,14428099 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,04916357 0,14405161 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,04916357 0,14382295 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,04916357 0,14359502 ! filopodium assembly GO:0046847 7 5 0,000 0,04916357 0,14336782 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,04916357 0,14314133 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,04916357 0,14291555 ! GTP metabolic process GO:0046039 5 5 0,000 0,04916357 0,14269049 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,04916357 0,14246613 ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,04916357 0,14224248 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,04916357 0,14201953 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,04916357 0,14179728 ! social behavior GO:0035176 5 5 0,000 0,04916357 0,14157572 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,04916357 0,14135485 ! memory GO:0007613 5 5 0,000 0,04916357 0,14113467 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,04916357 0,14091518 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,04916357 0,14069637 ! response to lipid GO:0033993 5 5 0,000 0,04916357 0,14047823 ! erythrocyte maturation GO:0043249 5 5 0,000 0,04916357 0,14026077 ! hippocampus development GO:0021766 6 5 0,000 0,04916357 0,14004399 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,04916357 0,13982787 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,04916357 0,13961242 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,04916357 0,13939763 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,04916357 0,1391835 ! mechanosensory behavior GO:0007638 5 5 0,000 0,04916357 0,13897003 ! heart looping GO:0001947 5 5 0,000 0,04916357 0,13875721 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,04916357 0,13854505 ! response to interferon-gamma GO:0034341 5 5 0,000 0,04916357 0,13833353 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,04916357 0,13812265 ! endocrine pancreas development GO:0031018 5 5 0,000 0,04916357 0,13791242 ! pH reduction GO:0045851 5 5 0,000 0,04916357 0,13770283 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,04916357 0,13749387 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,04916357 0,13728555 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,04916357 0,13707785 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,04916357 0,13687079 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,04916357 0,13666434 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,04916357 0,13645852 ! adrenal gland development GO:0030325 5 5 0,000 0,04916357 0,13625332 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,04916357 0,13604874 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,04916357 0,13584477 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,04916357 0,13564141 ! astrocyte differentiation GO:0048708 5 5 0,000 0,04916357 0,13543866 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,04916357 0,13523651 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,04916357 0,13503496 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,04916357 0,13483402 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,04916357 0,13463367 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,04916357 0,13443392 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,04916357 0,13423476 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,04916357 0,13403618 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,04916357 0,1338382 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,04916357 0,1336408 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,04916357 0,13344398 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,04916357 0,13324774 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,04916357 0,13305207 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,04916357 0,13285698 ! response to ATP GO:0033198 5 5 0,000 0,04916357 0,13266246 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,04916357 0,13246851 ! regulation of appetite GO:0032098 5 5 0,000 0,04916357 0,13227512 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,04916357 0,1320823 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,04916357 0,13189004 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,04916357 0,13169834 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04916357 0,1315072 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,04916357 0,13131661 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,04916357 0,13112657 ! retinol metabolic process GO:0042572 5 5 0,000 0,04916357 0,13093708 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,04916357 0,13074814 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,04916357 0,13055974 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,04916357 0,13037189 ! parturition GO:0007567 5 5 0,000 0,04916357 0,13018457 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,04916357 0,12999779 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 0,000 0,04916357 0,12981155 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,04916357 0,12962584 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,04916357 0,12944066 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,04916357 0,12925601 ! protein heterooligomerization GO:0051291 5 5 0,000 0,04916357 0,12907188 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,04916357 0,12888828 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,04916357 0,1287052 ! oligodendrocyte development GO:0014003 5 5 0,000 0,04916357 0,12852264 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,04916357 0,1283406 ! activated T cell proliferation GO:0050798 5 5 0,000 0,04916357 0,12815907 ! interaction with symbiont GO:0051702 5 5 0,000 0,04916357 0,12797805 ! cellular extravasation GO:0045123 5 5 0,000 0,04916357 0,12779755 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,04916357 0,12761755 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,04916357 0,12743806 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,04916357 0,12725907 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,04916357 0,12708059 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,04916357 0,12690261 ! response to amine stimulus GO:0014075 5 5 0,000 0,04916357 0,12672512 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,04916357 0,12654813 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,04916357 0,12637163 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,04916357 0,12619563 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,04916357 0,12602011 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,04916357 0,12584508 ! neuron recognition GO:0008038 5 5 0,000 0,04916357 0,12567054 ! decidualization GO:0046697 5 5 0,000 0,04916357 0,12549648 ! hair follicle maturation GO:0048820 5 5 0,000 0,04916357 0,12532291 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,04916357 0,12514981 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,04916357 0,12497719 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,04916357 0,12480504 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,04916357 0,12463337 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,04916357 0,12446217 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,04916357 0,12429144 GO:0021517|ventral spinal cord development, ! histone methylation GO:0016571 5 5 0,000 0,04916357 0,12412118 ! DNA methylation GO:0006306 5 5 0,000 0,04916357 0,12395138 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04916357 0,12378205 ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,04916357 0,12361318 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,04916357 0,12344477 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,04916357 0,12327682 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,04916357 0,12310932 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,04916357 0,12294228 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,04916357 0,12277569 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,04916357 0,12260955 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,04916357 0,12244387 ! sterol catabolic process GO:0016127 5 5 0,000 0,04916357 0,12227862 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,04916357 0,12211383 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,04916357 0,12194948 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,04916357 0,12178557 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,04916357 0,12162209 ! zymogen activation GO:0031638 5 5 0,000 0,04916357 0,12145906 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,04916357 0,12129647 ! cellular response to nutrient GO:0031670 5 5 0,000 0,04916357 0,12113431 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,04916357 0,12097258 ! nucleosome positioning GO:0016584 5 5 0,000 0,04916357 0,12081128 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,04916357 0,12065041 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,04916357 0,12048997 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,04916357 0,12032996 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,04916357 0,12017037 ! NADPH regeneration GO:0006740 5 5 0,000 0,04916357 0,12001121 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,04916357 0,11985246 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,04916357 0,11969414 ! musculoskeletal movement GO:0050881 5 5 0,000 0,04916357 0,11953623 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,04916357 0,11937874 ! sarcomere organization GO:0045214 5 5 0,000 0,04916357 0,11922166 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,04916357 0,11906499 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,04916357 0,11890874 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,04916357 0,1187529 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,04916357 0,11859746 GO:0045622|regulation of T-helper cell differentiation, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,04916357 0,11844243 ! male genitalia development GO:0030539 5 5 0,000 0,04916357 0,11828781 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,04916357 0,11813359 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,04916357 0,11797977 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,04916357 0,11782635 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,04916357 0,11767333 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,04916357 0,1175207 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,04916357 0,11736847 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,04916357 0,11721664 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,04916357 0,11706519 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,04916357 0,11691414 ! ATP catabolic process GO:0006200 5 5 0,000 0,04916357 0,11676348 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04916357 0,11661321 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,04916357 0,11646332 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,04916357 0,11631381 ! embryonic gut development GO:0048566 5 5 0,000 0,04916357 0,11616469 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,04916357 0,11601595 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,04916357 0,1158676 ! activation of innate immune response GO:0002218 5 5 0,000 0,04916357 0,11571962 GO:0002758|innate immune response-activating signal transduction, ! catecholamine transport GO:0051937 5 5 0,000 0,04916357 0,11557202 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,04916357 0,11542479 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,04916357 0,11527794 ! muscle adaptation GO:0043500 5 5 0,000 0,04916357 0,11513146 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,04916357 0,11498536 ! embryonic heart tube development GO:0035050 5 5 0,000 0,04916357 0,11483962 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,04916357 0,11469425 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,04916357 0,11454925 ! defense response to fungus GO:0050832 5 5 0,000 0,04916357 0,11440462 ! lysogeny GO:0030069 5 5 0,000 0,04916357 0,11426035 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,04916357 0,11411645 ! establishment of cell polarity GO:0030010 5 5 0,000 0,04916357 0,11397291 ! mitochondrion localization GO:0051646 5 5 0,000 0,04916357 0,11382972 ! nucleus localization GO:0051647 5 5 0,000 0,04916357 0,1136869 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,04916357 0,11354444 ! response to inorganic substance GO:0010035 36 36 1,000 0,05018018 0,11574728 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 1,000 0,05018018 0,1156026 ! regulation of mitosis GO:0007088 37 36 1,000 0,05018018 0,11545828 GO:0051783|regulation of nuclear division, ! positive regulation of phosphorus metabolic process GO:0010562 36 36 1,000 0,05018018 0,11531431 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of lipase activity GO:0060191 36 36 1,000 0,05018018 0,11517071 ! activation of immune response GO:0002253 36 36 1,000 0,05018018 0,11502746 ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 0,0527117 0,12068033 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! adaptive immune response GO:0002250 37 37 1,000 0,0527117 0,1205306 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! positive regulation of cell differentiation GO:0045597 87 85 2,000 0,05325422 0,12162022 ! cellular hormone metabolic process GO:0034754 39 38 1,000 0,05528806 0,12610879 ! axon guidance GO:0007411 39 38 1,000 0,05528806 0,1259529 ! steroid hormone receptor signaling pathway GO:0030518 38 38 1,000 0,05528806 0,12579741 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 0,05790814 0,13159644 ! nucleotide-excision repair GO:0006289 40 39 1,000 0,05790814 0,13143437 ! positive regulation of T cell activation GO:0050870 39 39 1,000 0,05790814 0,13127271 ! protein oligomerization GO:0051259 39 39 1,000 0,05790814 0,13111144 ! nucleoside monophosphate metabolic process GO:0009123 39 39 1,000 0,05790814 0,13095057 ! intracellular protein transmembrane transport GO:0065002 39 39 1,000 0,05790814 0,13079009 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,05870651 0,13243097 ! axon extension GO:0048675 7 6 0,000 0,05870651 0,13226907 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,05870651 0,13210757 ! tRNA modification GO:0006400 6 6 0,000 0,05870651 0,13194646 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,05870651 0,13178575 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,05870651 0,13162542 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,05870651 0,13146549 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,05870651 0,13130595 ! virus-host interaction GO:0019048 6 6 0,000 0,05870651 0,13114679 ! myotube differentiation GO:0014902 6 6 0,000 0,05870651 0,13098801 ! bone remodeling GO:0046849 6 6 0,000 0,05870651 0,13082962 ! N-glycan processing GO:0006491 6 6 0,000 0,05870651 0,13067162 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,05870651 0,13051399 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,05870651 0,13035675 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,05870651 0,13019988 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,05870651 0,13004339 ! RNA methylation GO:0001510 6 6 0,000 0,05870651 0,12988727 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,05870651 0,12973153 ! succinate metabolic process GO:0006105 7 6 0,000 0,05870651 0,12957617 ! artery development GO:0060840 6 6 0,000 0,05870651 0,12942117 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,05870651 0,12926655 ! androgen metabolic process GO:0008209 6 6 0,000 0,05870651 0,12911229 ! estrogen metabolic process GO:0008210 6 6 0,000 0,05870651 0,1289584 ! limbic system development GO:0021761 7 6 0,000 0,05870651 0,12880488 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,05870651 0,12865172 ! pathogenesis GO:0009405 6 6 0,000 0,05870651 0,12849893 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,05870651 0,1283465 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,05870651 0,12819443 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,05870651 0,12804272 ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,05870651 0,12789137 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,05870651 0,12774038 ! arginine metabolic process GO:0006525 6 6 0,000 0,05870651 0,12758974 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,05870651 0,12743946 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,05870651 0,12728953 ! glutamate catabolic process GO:0006538 7 6 0,000 0,05870651 0,12713995 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,05870651 0,12699073 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,05870651 0,12684185 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,05870651 0,12669332 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 0,05870651 0,12654515 ! V(D)J recombination GO:0033151 6 6 0,000 0,05870651 0,12639731 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,05870651 0,12624982 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,05870651 0,12610268 ! lipid digestion GO:0044241 6 6 0,000 0,05870651 0,12595588 ! asymmetric protein localization GO:0008105 6 6 0,000 0,05870651 0,12580942 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,05870651 0,1256633 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,05870651 0,12551752 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,05870651 0,12537207 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,05870651 0,12522697 ! ruffle organization GO:0031529 6 6 0,000 0,05870651 0,1250822 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,05870651 0,12493776 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,05870651 0,12479366 ! neutral amino acid transport GO:0015804 6 6 0,000 0,05870651 0,12464988 ! L-amino acid transport GO:0015807 6 6 0,000 0,05870651 0,12450644 ! bone mineralization GO:0030282 6 6 0,000 0,05870651 0,12436333 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,05870651 0,12422055 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,05870651 0,1240781 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,05870651 0,12393597 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,05870651 0,12379416 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,05870651 0,12365268 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,05870651 0,12351153 ! regulation of organ growth GO:0046620 6 6 0,000 0,05870651 0,12337069 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,05870651 0,12323018 ! response to dsRNA GO:0043331 6 6 0,000 0,05870651 0,12308999 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,05870651 0,12295011 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,05870651 0,12281056 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,05870651 0,12267131 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,05870651 0,12253239 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,05870651 0,12239378 ! multicellular organismal aging GO:0010259 6 6 0,000 0,05870651 0,12225548 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,05870651 0,12211749 ! erythrocyte development GO:0048821 6 6 0,000 0,05870651 0,12197982 ! renal water homeostasis GO:0003091 6 6 0,000 0,05870651 0,12184245 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,05870651 0,1217054 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,05870651 0,12156865 ! ribosome assembly GO:0042255 6 6 0,000 0,05870651 0,12143221 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,05870651 0,12129608 ! diencephalon development GO:0021536 6 6 0,000 0,05870651 0,12116025 ! fucose catabolic process GO:0019317 6 6 0,000 0,05870651 0,12102472 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,05870651 0,1208895 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 0,05870651 0,12075458 ! regulation of lipid transport GO:0032368 6 6 0,000 0,05870651 0,12061995 ! regulation of cell division GO:0051302 6 6 0,000 0,05870651 0,12048563 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,05870651 0,12035161 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,05870651 0,12021789 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,05870651 0,12008446 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,05870651 0,11995133 ! neuroblast proliferation GO:0007405 6 6 0,000 0,05870651 0,11981849 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,05870651 0,11968595 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,05870651 0,1195537 ! regulation of glucose transport GO:0010827 6 6 0,000 0,05870651 0,11942174 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,05870651 0,11929008 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,05870651 0,1191587 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,05870651 0,11902761 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 0,05870651 0,11889681 ! lymph node development GO:0048535 6 6 0,000 0,05870651 0,1187663 ! organic cation transport GO:0015695 6 6 0,000 0,05870651 0,11863607 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,05870651 0,11850613 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,05870651 0,11837648 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 0,000 0,05870651 0,1182471 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,05870651 0,11811801 ! sperm-egg recognition GO:0035036 7 6 0,000 0,05870651 0,1179892 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,05870651 0,11786067 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,05870651 0,11773243 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,05870651 0,11760446 ! alditol metabolic process GO:0019400 6 6 0,000 0,05870651 0,11747676 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,05870651 0,11734935 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,05870651 0,11722221 ! maternal placenta development GO:0001893 6 6 0,000 0,05870651 0,11709535 ! regulation of embryonic development GO:0045995 6 6 0,000 0,05870651 0,11696876 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 0,06057084 0,12055298 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 1,000 0,06057084 0,12042293 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 0,06327506 0,12566372 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of caspase activity GO:0043281 41 41 1,000 0,06327506 0,12552846 ! fatty acid metabolic process GO:0006631 93 92 2,000 0,06448504 0,12779133 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 0,06601973 0,13069212 ! regulation of endopeptidase activity GO:0052548 42 42 1,000 0,06601973 0,13055189 ! protein ubiquitination GO:0016567 43 42 1,000 0,06601973 0,13041196 ! response to protein stimulus GO:0051789 42 42 1,000 0,06601973 0,13027234 ! tissue morphogenesis GO:0048729 94 93 2,000 0,06617257 0,13043427 ! pattern specification process GO:0007389 96 94 2,000 0,06788041 0,13365769 ! respiratory burst GO:0045730 7 7 0,000 0,06815505 0,13405523 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,06815505 0,13391232 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 0,06815505 0,13376971 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,06815505 0,1336274 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,06815505 0,13348539 ! positive regulation of cellular catabolic process GO:0031331 7 7 0,000 0,06815505 0,13334369 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,06815505 0,13320229 ! regulation of chemokine production GO:0032642 7 7 0,000 0,06815505 0,13306118 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,06815505 0,13292038 GO:0000725|recombinational repair, ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,06815505 0,13277987 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,06815505 0,13263966 GO:0043241|protein complex disassembly, ! gene silencing by RNA GO:0031047 7 7 0,000 0,06815505 0,13249974 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,06815505 0,13236012 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,06815505 0,13222079 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,06815505 0,13208176 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,06815505 0,13194302 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,06815505 0,13180457 ! visual behavior GO:0007632 7 7 0,000 0,06815505 0,13166641 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,06815505 0,13152854 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,06815505 0,13139096 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,06815505 0,13125366 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,06815505 0,13111665 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,06815505 0,13097993 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,06815505 0,13084349 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,06815505 0,13070734 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,06815505 0,13057147 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,06815505 0,13043588 ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,06815505 0,13030058 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,06815505 0,13016555 ! protein targeting to ER GO:0045047 8 7 0,000 0,06815505 0,1300308 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,06815505 0,12989633 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,06815505 0,12976214 ! endoderm development GO:0007492 7 7 0,000 0,06815505 0,12962823 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,06815505 0,12949459 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,06815505 0,12936123 GO:0006688|glycosphingolipid biosynthetic process, ! regulation of mRNA processing GO:0050684 7 7 0,000 0,06815505 0,12922814 ! response to hexose stimulus GO:0009746 7 7 0,000 0,06815505 0,12909533 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,06815505 0,12896279 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,06815505 0,12883052 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,06815505 0,12869852 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,06815505 0,12856679 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,06815505 0,12843533 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,06815505 0,12830414 ! UV protection GO:0009650 7 7 0,000 0,06815505 0,12817322 ! DNA integration GO:0015074 7 7 0,000 0,06815505 0,12804256 ! myofibril assembly GO:0030239 7 7 0,000 0,06815505 0,12791217 GO:0055002|striated muscle cell development, ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 0,000 0,06815505 0,12778205 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,06815505 0,12765219 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,06815505 0,12752259 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,06815505 0,12739326 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,06815505 0,12726419 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,06815505 0,12713538 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,06815505 0,12700683 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,06815505 0,12687854 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,06815505 0,12675051 ! eating behavior GO:0042755 7 7 0,000 0,06815505 0,12662274 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,06815505 0,12649522 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,06815505 0,12636796 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,06815505 0,12624096 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,06815505 0,12611421 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,06815505 0,12598772 ! cranial nerve development GO:0021545 7 7 0,000 0,06815505 0,12586148 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,06815505 0,12573549 ! induction of an organ GO:0001759 7 7 0,000 0,06815505 0,12560975 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,06815505 0,12548427 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,06815505 0,12535904 ! autonomic nervous system development GO:0048483 7 7 0,000 0,06815505 0,12523405 ! intracellular lipid transport GO:0032365 7 7 0,000 0,06815505 0,12510932 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,06815505 0,12498483 ! platelet activation GO:0030168 8 7 0,000 0,06815505 0,12486059 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,06815505 0,1247366 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,06815505 0,12461285 ! natural killer cell activation GO:0030101 7 7 0,000 0,06815505 0,12448935 ! NADP metabolic process GO:0006739 7 7 0,000 0,06815505 0,12436609 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,06815505 0,12424308 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,06815505 0,12412031 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,06815505 0,12399778 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,06815505 0,1238755 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,06815505 0,12375345 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,06815505 0,12363165 ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,06815505 0,12351008 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,06815505 0,12338876 ! cell-cell recognition GO:0009988 8 7 0,000 0,06815505 0,12326767 ! hormone catabolic process GO:0042447 7 7 0,000 0,06815505 0,12314682 ! dopamine metabolic process GO:0042417 7 7 0,000 0,06815505 0,1230262 ! oxygen transport GO:0015671 7 7 0,000 0,06815505 0,12290583 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,06815505 0,12278568 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,06815505 0,12266578 ! regulation of axon extension GO:0030516 7 7 0,000 0,06815505 0,1225461 ! cell killing GO:0001906 7 7 0,000 0,06815505 0,12242666 ! adult feeding behavior GO:0008343 7 7 0,000 0,06815505 0,12230745 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,06815505 0,12218848 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,06815505 0,12206973 ! response to cold GO:0009409 7 7 0,000 0,06815505 0,12195122 ! homeostasis of number of cells GO:0048872 44 43 1,000 0,06880379 0,12299262 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 0,06880379 0,12287344 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 1,000 0,06880379 0,12275449 ! humoral immune response GO:0006959 44 44 1,000 0,07162621 0,12766645 ! mRNA transport GO:0051028 44 44 1,000 0,07162621 0,1275431 ! positive regulation of lymphocyte activation GO:0051251 44 44 1,000 0,07162621 0,12741999 ! homophilic cell adhesion GO:0007156 45 45 1,000 0,07448596 0,13237959 ! steroid biosynthetic process GO:0006694 46 45 1,000 0,07448596 0,13225205 ! regulation of system process GO:0044057 98 98 2,000 0,07491169 0,13287992 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 1,000 0,07738204 0,1371299 ! regulation of peptidase activity GO:0052547 46 46 1,000 0,07738204 0,13699817 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,07751011 0,13709321 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,07751011 0,13696177 ! positive regulation of translation GO:0045727 8 8 0,000 0,07751011 0,13683058 ! superoxide anion generation GO:0042554 8 8 0,000 0,07751011 0,13669964 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,07751011 0,13656895 ! cGMP metabolic process GO:0046068 8 8 0,000 0,07751011 0,13643851 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,07751011 0,13630832 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,07751011 0,13617838 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,07751011 0,13604869 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,07751011 0,13591924 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,07751011 0,13579004 ! zinc ion transport GO:0006829 8 8 0,000 0,07751011 0,13566109 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,07751011 0,13553238 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,07751011 0,13540391 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,07751011 0,13527569 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,07751011 0,1351477 ! lipid localization GO:0010876 8 8 0,000 0,07751011 0,13501997 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,07751011 0,13489247 ! response to cAMP GO:0051591 8 8 0,000 0,07751011 0,13476521 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,07751011 0,13463819 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,07751011 0,13451142 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,07751011 0,13438488 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,07751011 0,13425857 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,07751011 0,13413251 ! sensory perception of taste GO:0050909 8 8 0,000 0,07751011 0,13400668 ! organelle fusion GO:0048284 8 8 0,000 0,07751011 0,13388109 ! pancreas development GO:0031016 8 8 0,000 0,07751011 0,13375573 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,07751011 0,13363061 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,07751011 0,13350572 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,07751011 0,13338107 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,07751011 0,13325665 ! sperm motility GO:0030317 8 8 0,000 0,07751011 0,13313245 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,07751011 0,13300849 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,07751011 0,13288477 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,07751011 0,13276127 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,07751011 0,132638 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,07751011 0,13251496 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,07751011 0,13239214 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,07751011 0,13226956 ! Golgi organization GO:0007030 8 8 0,000 0,07751011 0,1321472 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,07751011 0,13202507 ! fructose metabolic process GO:0006000 8 8 0,000 0,07751011 0,13190316 ! mannose metabolic process GO:0006013 9 8 0,000 0,07751011 0,13178148 ! NAD metabolic process GO:0019674 8 8 0,000 0,07751011 0,13166002 ! response to fungus GO:0009620 8 8 0,000 0,07751011 0,13153879 ! stem cell differentiation GO:0048863 8 8 0,000 0,07751011 0,13141778 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,07751011 0,13129699 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,07751011 0,13117642 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,07751011 0,13105608 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,07751011 0,13093595 ! regulation of vasodilation GO:0042312 8 8 0,000 0,07751011 0,13081605 ! muscle cell development GO:0055001 8 8 0,000 0,07751011 0,13069636 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,07751011 0,1305769 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,07751011 0,13045765 ! sensory perception of pain GO:0019233 8 8 0,000 0,07751011 0,13033862 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,07751011 0,1302198 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,07751011 0,13010121 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,07751011 0,12998282 ! chromatin silencing GO:0006342 8 8 0,000 0,07751011 0,12986466 ! tissue regeneration GO:0042246 8 8 0,000 0,07751011 0,12974671 ! salivary gland development GO:0007431 8 8 0,000 0,07751011 0,12962897 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,07751011 0,12951144 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,07751011 0,12939413 ! water homeostasis GO:0030104 8 8 0,000 0,07751011 0,12927703 ! cofactor transport GO:0051181 8 8 0,000 0,07751011 0,12916015 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,07751011 0,12904347 ! acid secretion GO:0046717 8 8 0,000 0,07751011 0,12892701 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,07751011 0,12881075 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,07751011 0,12869471 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,07751011 0,12857887 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,07751011 0,12846324 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 0,000 0,07751011 0,12834782 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,07751011 0,12823261 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,07751011 0,1281176 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,07751011 0,1280028 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,07751011 0,1278882 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,07751011 0,12777381 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,07751011 0,12765963 ! developmental induction GO:0031128 8 8 0,000 0,07751011 0,12754565 GO:0045168|cell-cell signaling involved in cell fate specification, ! peptide hormone secretion GO:0030072 8 8 0,000 0,07751011 0,12743187 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,07751011 0,12731829 ! actin filament polymerization GO:0030041 9 8 0,000 0,07751011 0,12720492 ! peptide hormone processing GO:0016486 8 8 0,000 0,07751011 0,12709175 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,07751011 0,12697878 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,07751011 0,12686601 ! response to other organism GO:0051707 101 100 2,000 0,07854489 0,12844564 ! regulation of blood pressure GO:0008217 48 47 1,000 0,08031345 0,13122135 ! rhythmic process GO:0048511 47 47 1,000 0,08031345 0,13110512 ! calcium ion transport GO:0006816 48 48 1,000 0,08327921 0,13582619 ! glycerophospholipid metabolic process GO:0006650 49 48 1,000 0,08327921 0,13570609 ! divalent metal ion transport GO:0070838 49 49 1,000 0,08627838 0,14046913 ! positive regulation of cell activation GO:0050867 49 49 1,000 0,08627838 0,14034515 GO:0002696|positive regulation of leukocyte activation, ! lactation GO:0007595 10 9 0,000 0,08677259 0,14102459 ! embryonic pattern specification GO:0009880 10 9 0,000 0,08677259 0,14090034 ! positive regulation of cell size GO:0045793 9 9 0,000 0,08677259 0,14077631 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,08677259 0,14065249 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,08677259 0,1405289 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,08677259 0,14040552 ! negative regulation of cell cycle process GO:0010948 9 9 0,000 0,08677259 0,14028236 ! viral genome replication GO:0019079 9 9 0,000 0,08677259 0,14015941 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,08677259 0,14003668 ! copper ion transport GO:0006825 9 9 0,000 0,08677259 0,13991416 ! lipid phosphorylation GO:0046834 9 9 0,000 0,08677259 0,13979186 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,08677259 0,13966977 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,08677259 0,13954789 ! RNA polyadenylation GO:0043631 9 9 0,000 0,08677259 0,13942623 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,08677259 0,13930478 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,08677259 0,13918354 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,08677259 0,13906251 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,08677259 0,13894169 ! phospholipid efflux GO:0033700 9 9 0,000 0,08677259 0,13882108 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,08677259 0,13870068 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,08677259 0,13858049 GO:0042107|cytokine metabolic process, ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,08677259 0,13846051 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,08677259 0,13834073 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,08677259 0,13822116 ! methionine metabolic process GO:0006555 9 9 0,000 0,08677259 0,1381018 ! glutamine metabolic process GO:0006541 9 9 0,000 0,08677259 0,13798264 ! cerebral cortex development GO:0021987 9 9 0,000 0,08677259 0,13786369 ! response to osmotic stress GO:0006970 9 9 0,000 0,08677259 0,13774495 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,08677259 0,13762641 ! central nervous system neuron development GO:0021954 10 9 0,000 0,08677259 0,13750807 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,08677259 0,13738994 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,08677259 0,137272 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,08677259 0,13715428 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,08677259 0,13703675 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,08677259 0,13691942 ! L-glutamate transport GO:0015813 9 9 0,000 0,08677259 0,1368023 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,08677259 0,13668537 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,08677259 0,13656865 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,08677259 0,13645212 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,08677259 0,13633579 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,08677259 0,13621966 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,08677259 0,13610373 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,08677259 0,135988 GO:0006692|prostanoid metabolic process, ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,08677259 0,13587246 ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,08677259 0,13575712 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,08677259 0,13564197 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,08677259 0,13552702 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,08677259 0,13541227 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,08677259 0,1352977 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,08677259 0,13518333 ! collagen catabolic process GO:0030574 9 9 0,000 0,08677259 0,13506916 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,08677259 0,13495518 ! purine base metabolic process GO:0006144 9 9 0,000 0,08677259 0,13484139 ! gas transport GO:0015669 9 9 0,000 0,08677259 0,13472779 ! cholesterol efflux GO:0033344 9 9 0,000 0,08677259 0,13461438 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,08677259 0,13450116 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,08677259 0,13438814 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,08677259 0,1342753 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,08677259 0,13416266 ! actin filament-based movement GO:0030048 9 9 0,000 0,08677259 0,1340502 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,08677259 0,13393793 ! RNA transport GO:0050658 50 50 1,000 0,08931 0,13773918 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 1,000 0,08931 0,13762402 ! anatomical structure homeostasis GO:0060249 51 50 1,000 0,08931 0,13750904 ! anterior/posterior pattern formation GO:0009952 51 50 1,000 0,08931 0,13739426 ! protein modification by small protein conjugation GO:0032446 52 51 1,000 0,09237314 0,14198807 ! positive regulation of immune response GO:0050778 51 51 1,000 0,09237314 0,14186975 ! rRNA metabolic process GO:0016072 51 51 1,000 0,09237314 0,14175162 GO:0006364|rRNA processing, ! RNA localization GO:0006403 52 52 1,000 0,09546689 0,14637727 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 1,000 0,09546689 0,14625559 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,09594341 0,14686354 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,09594341 0,14674166 ! regulation of glucose metabolic process GO:0010906 10 10 0,000 0,09594341 0,14661999 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,09594341 0,14649851 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! neuron maturation GO:0042551 10 10 0,000 0,09594341 0,14637724 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,09594341 0,14625616 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,09594341 0,14613529 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,09594341 0,14601462 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,09594341 0,14589414 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,09594341 0,14577387 ! hormone secretion GO:0046879 10 10 0,000 0,09594341 0,14565379 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,09594341 0,14553391 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,09594341 0,14541423 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,09594341 0,14529474 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,09594341 0,14517545 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,09594341 0,14505636 ! glial cell development GO:0021782 10 10 0,000 0,09594341 0,14493746 ! phototransduction GO:0007602 11 10 0,000 0,09594341 0,14481876 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,09594341 0,14470025 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,09594341 0,14458193 ! fat cell differentiation GO:0045444 10 10 0,000 0,09594341 0,14446381 ! myoblast differentiation GO:0045445 10 10 0,000 0,09594341 0,14434588 ! centrosome cycle GO:0007098 10 10 0,000 0,09594341 0,14422814 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,09594341 0,1441106 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,09594341 0,14399324 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,09594341 0,14387608 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,09594341 0,14375911 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,09594341 0,14364233 ! protein polyubiquitination GO:0000209 10 10 0,000 0,09594341 0,14352573 ! glutamate metabolic process GO:0006536 11 10 0,000 0,09594341 0,14340933 ! plasma membrane organization GO:0007009 10 10 0,000 0,09594341 0,14329311 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,09594341 0,14317709 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,09594341 0,14306125 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,09594341 0,1429456 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,09594341 0,14283013 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,09594341 0,14271485 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,09594341 0,14259976 ! exocrine system development GO:0035272 10 10 0,000 0,09594341 0,14248485 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,09594341 0,14237013 ! embryo implantation GO:0007566 11 10 0,000 0,09594341 0,14225559 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,09594341 0,14214124 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,09594341 0,14202707 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,09594341 0,14191308 ! protein export from nucleus GO:0006611 10 10 0,000 0,09594341 0,14179928 ! cytolysis GO:0019835 10 10 0,000 0,09594341 0,14168566 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,09594341 0,14157222 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,09594341 0,14145896 ! histone deacetylation GO:0016575 10 10 0,000 0,09594341 0,14134589 ! mRNA splice site selection GO:0006376 11 10 0,000 0,09594341 0,14123299 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,09594341 0,14112027 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,09594341 0,14100774 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,09594341 0,14089538 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,09594341 0,1407832 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,09594341 0,1406712 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,09594341 0,14055938 ! regulation of epidermis development GO:0045682 10 10 0,000 0,09594341 0,14044774 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,09594341 0,14033627 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,09594341 0,14022498 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,09594341 0,14011387 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,09594341 0,14000293 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,09594341 0,13989217 ! nerve development GO:0021675 10 10 0,000 0,09594341 0,13978158 ! epithelial to mesenchymal transition GO:0001837 10 10 0,000 0,09594341 0,13967117 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,09594341 0,13956093 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,09594341 0,13945087 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,09594341 0,13934098 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 1,000 0,09859035 0,14307245 ! hormone metabolic process GO:0042445 55 54 1,000 0,10174263 0,14753082 ! sulfur metabolic process GO:0006790 55 54 1,000 0,10174263 0,14741484 ! microtubule cytoskeleton organization GO:0000226 55 55 1,000 0,10492287 0,15190326 ! protein modification by small protein conjugation or removal GO:0070647 56 55 1,000 0,10492287 0,15178402 ! protein secretion GO:0009306 11 11 0,000 0,10502345 0,15181037 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,10502345 0,1516914 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,10502345 0,15157261 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,10502345 0,15145401 ! negative regulation of defense response GO:0031348 11 11 0,000 0,10502345 0,15133559 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,10502345 0,15121736 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,10502345 0,15109932 ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,10502345 0,15098145 ! skin development GO:0043588 11 11 0,000 0,10502345 0,15086378 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,10502345 0,15074628 ! peroxisomal transport GO:0043574 11 11 0,000 0,10502345 0,15062897 ! protein amino acid methylation GO:0006479 11 11 0,000 0,10502345 0,15051184 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,10502345 0,15039489 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,10502345 0,15027812 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,10502345 0,15016154 ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,10502345 0,15004514 ! spinal cord development GO:0021510 11 11 0,000 0,10502345 0,14992891 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,10502345 0,14981287 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,10502345 0,149697 ! digestive system process GO:0022600 11 11 0,000 0,10502345 0,14958132 ! mitotic spindle organization GO:0007052 11 11 0,000 0,10502345 0,14946581 ! fucose metabolic process GO:0006004 11 11 0,000 0,10502345 0,14935048 ! membrane budding GO:0006900 11 11 0,000 0,10502345 0,14923533 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,10502345 0,14912036 ! monoamine transport GO:0015844 11 11 0,000 0,10502345 0,14900556 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,10502345 0,14889094 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,10502345 0,1487765 ! body fluid secretion GO:0007589 11 11 0,000 0,10502345 0,14866223 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,10502345 0,14854814 GO:0060415|muscle tissue morphogenesis, ! interaction with host GO:0051701 11 11 0,000 0,10502345 0,14843422 ! membrane depolarization GO:0051899 11 11 0,000 0,10502345 0,14832048 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,10502345 0,14820691 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,10502345 0,14809352 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 0,000 0,10502345 0,14798029 GO:0006109|regulation of carbohydrate metabolic process, ! vitamin transport GO:0051180 11 11 0,000 0,10502345 0,14786725 ! muscle maintenance GO:0046716 12 11 0,000 0,10502345 0,14775437 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,10502345 0,14764167 ! steroid catabolic process GO:0006706 11 11 0,000 0,10502345 0,14752913 ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,10502345 0,14741677 ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,10502345 0,14730458 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,10502345 0,14719257 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,10502345 0,14708072 ! extracellular structure organization GO:0043062 56 56 1,000 0,1081302 0,15131659 ! positive regulation of protein catabolic process GO:0045732 12 12 0,000 0,11401361 0,15942874 ! translational initiation GO:0006413 12 12 0,000 0,11401361 0,15930787 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,11401361 0,15918718 ! positive regulation of angiogenesis GO:0045766 12 12 0,000 0,11401361 0,15906668 ! initiation of viral infection GO:0019059 12 12 0,000 0,11401361 0,15894636 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,11401361 0,15882621 ! iron ion transport GO:0006826 13 12 0,000 0,11401361 0,15870626 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,11401361 0,15858648 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,11401361 0,15846688 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,11401361 0,15834746 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,11401361 0,15822822 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,11401361 0,15810917 ! collagen metabolic process GO:0032963 12 12 0,000 0,11401361 0,15799029 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,11401361 0,15787159 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,11401361 0,15775306 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,11401361 0,15763472 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,11401361 0,15751655 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,11401361 0,15739856 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,11401361 0,15728075 ! actomyosin structure organization GO:0031032 12 12 0,000 0,11401361 0,15716311 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,11401361 0,15704565 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,11401361 0,15692837 ! retinoid metabolic process GO:0001523 12 12 0,000 0,11401361 0,15681126 GO:0016101|diterpenoid metabolic process, ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,11401361 0,15669432 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,11401361 0,15657756 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,11401361 0,15646097 ! acute-phase response GO:0006953 12 12 0,000 0,11401361 0,15634456 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,11401361 0,15622831 ! vacuolar transport GO:0007034 12 12 0,000 0,11401361 0,15611225 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,11401361 0,15599635 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,11401361 0,15588062 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,11401361 0,15576507 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,11401361 0,15564969 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,11401361 0,15553448 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,11401361 0,15541944 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,11401361 0,15530457 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,11401361 0,15518987 ! pallium development GO:0021543 13 12 0,000 0,11401361 0,15507534 ! cell fate determination GO:0001709 12 12 0,000 0,11401361 0,15496097 ! regulation of chromosome organization GO:0033044 12 12 0,000 0,11401361 0,15484678 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,11401361 0,15473276 ! detection of light stimulus GO:0009583 13 12 0,000 0,11401361 0,1546189 ! synaptogenesis GO:0007416 12 12 0,000 0,11401361 0,15450521 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,11401361 0,15439168 ! hormone transport GO:0009914 12 12 0,000 0,11401361 0,15427833 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,11401361 0,15416514 ! heme biosynthetic process GO:0006783 12 12 0,000 0,11401361 0,15405211 ! spermatid differentiation GO:0048515 13 12 0,000 0,11401361 0,15393925 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,11401361 0,15382656 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,11401361 0,15371403 ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 0,000 0,11401361 0,15360167 ! negative regulation of translation GO:0017148 12 12 0,000 0,11401361 0,15348947 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,12291475 0,16535175 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,12291475 0,16523114 ! phenol metabolic process GO:0018958 13 13 0,000 0,12291475 0,16511071 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! gluconeogenesis GO:0006094 13 13 0,000 0,12291475 0,16499045 ! negative regulation of hormone secretion GO:0046888 13 13 0,000 0,12291475 0,16487037 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,12291475 0,16475047 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,12291475 0,16463074 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,12291475 0,16451118 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,12291475 0,16439179 ! keratinization GO:0031424 13 13 0,000 0,12291475 0,16427258 ! patterning of blood vessels GO:0001569 13 13 0,000 0,12291475 0,16415354 ! regulation of innate immune response GO:0045088 13 13 0,000 0,12291475 0,16403468 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,12291475 0,16391599 ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,12291475 0,16379746 ! autophagy GO:0006914 13 13 0,000 0,12291475 0,16367911 ! actin filament bundle formation GO:0051017 13 13 0,000 0,12291475 0,16356093 ! coenzyme catabolic process GO:0009109 13 13 0,000 0,12291475 0,16344292 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,12291475 0,16332508 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,12291475 0,16320741 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,12291475 0,16308991 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,12291475 0,16297258 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,12291475 0,16285542 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,12291475 0,16273843 ! vasodilation GO:0042311 14 13 0,000 0,12291475 0,1626216 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,12291475 0,16250494 GO:0006664|glycolipid metabolic process, ! neural crest cell migration GO:0001755 14 13 0,000 0,12291475 0,16238845 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,12291475 0,16227213 ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,12291475 0,16215597 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,12291475 0,16203998 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,12291475 0,16192415 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,12291475 0,16180849 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,12291475 0,161693 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,12291475 0,16157767 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,12291475 0,1614625 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,12291475 0,1613475 ! telomere organization GO:0032200 13 13 0,000 0,12291475 0,16123266 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,12291475 0,16111799 ! regulation of amine transport GO:0051952 13 13 0,000 0,12291475 0,16100348 ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,12291475 0,16088913 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 1,000 0,12789691 0,16729171 ! negative regulation of cellular component organization GO:0051129 65 63 1,000 0,13127106 0,17158338 ! neuron fate commitment GO:0048663 14 14 0,000 0,13172776 0,17205829 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,13172776 0,17193644 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,13172776 0,17181476 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,13172776 0,17169325 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,13172776 0,17157191 ! acetyl-CoA metabolic process GO:0006084 14 14 0,000 0,13172776 0,17145074 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,13172776 0,17132975 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,13172776 0,17120892 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,13172776 0,17108827 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,13172776 0,17096778 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,13172776 0,17084747 ! superoxide metabolic process GO:0006801 15 14 0,000 0,13172776 0,17072732 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,13172776 0,17060735 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,13172776 0,17048754 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,13172776 0,1703679 ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,13172776 0,17024842 ! lysosome organization GO:0007040 14 14 0,000 0,13172776 0,17012912 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,13172776 0,17000998 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,13172776 0,16989101 ! peptide cross-linking GO:0018149 14 14 0,000 0,13172776 0,16977221 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,13172776 0,16965357 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,13172776 0,16953509 ! formation of primary germ layer GO:0001704 14 14 0,000 0,13172776 0,16941679 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,13172776 0,16929864 ! collagen fibril organization GO:0030199 14 14 0,000 0,13172776 0,16918066 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,13172776 0,16906285 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,13172776 0,1689452 ! positive regulation of inflammatory response GO:0050729 14 14 0,000 0,13172776 0,16882771 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,13172776 0,16871039 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,13172776 0,16859323 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,13172776 0,16847623 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,13172776 0,1683594 ! response to molecule of bacterial origin GO:0002237 14 14 0,000 0,13172776 0,16824273 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,13172776 0,16812621 ! glycerolipid metabolic process GO:0046486 65 64 1,000 0,13466593 0,17175731 ! regulation of cytoskeleton organization GO:0051493 66 64 1,000 0,13466593 0,17163853 ! positive regulation of cellular component organization GO:0051130 65 65 1,000 0,13808079 0,17586931 ! regulation of hormone levels GO:0010817 66 65 1,000 0,13808079 0,17574785 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,14045347 0,17864441 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,14045347 0,17852121 ! positive regulation of ossification GO:0045778 15 15 0,000 0,14045347 0,17839818 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,14045347 0,17827531 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,14045347 0,17815262 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,14045347 0,17803009 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,14045347 0,17790773 ! striated muscle cell differentiation GO:0051146 16 15 0,000 0,14045347 0,17778554 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,14045347 0,17766352 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,14045347 0,17754167 ! insulin receptor signaling pathway GO:0008286 17 15 0,000 0,14045347 0,17741998 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,14045347 0,17729846 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,14045347 0,17717711 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,14045347 0,17705592 ! heme metabolic process GO:0042168 15 15 0,000 0,14045347 0,1769349 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,14045347 0,17681404 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,14045347 0,17669335 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,14045347 0,17657282 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,14045347 0,17645246 GO:0030500|regulation of bone mineralization, ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,14045347 0,17633226 ! phospholipid transport GO:0015914 15 15 0,000 0,14045347 0,17621222 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,14045347 0,17609235 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,14045347 0,17597264 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,14045347 0,17585309 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,14045347 0,17573371 ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,14045347 0,17561449 ! protein homooligomerization GO:0051260 15 15 0,000 0,14045347 0,17549543 ! polysaccharide metabolic process GO:0005976 69 66 1,000 0,1415149 0,17670187 ! muscle contraction GO:0006936 67 67 1,000 0,14496756 0,18089047 ! negative regulation of cell differentiation GO:0045596 68 67 1,000 0,14496756 0,18076808 ! chromatin assembly or disassembly GO:0006333 68 68 1,000 0,14843807 0,1849705 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,14909276 0,18566078 ! alkaloid metabolic process GO:0009820 16 16 0,000 0,14909276 0,18553542 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,14909276 0,18541023 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,14909276 0,18528521 ! learning GO:0007612 16 16 0,000 0,14909276 0,18516035 ! circadian rhythm GO:0007623 16 16 0,000 0,14909276 0,18503566 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,14909276 0,18491114 ! positive regulation of mitosis GO:0045840 16 16 0,000 0,14909276 0,18478679 GO:0051785|positive regulation of nuclear division, ! vacuole organization GO:0007033 16 16 0,000 0,14909276 0,18466261 ! cellular response to reactive oxygen species GO:0034614 16 16 0,000 0,14909276 0,18453859 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,14909276 0,18441474 ! vesicle targeting GO:0006903 17 16 0,000 0,14909276 0,18429105 ! triglyceride metabolic process GO:0006641 16 16 0,000 0,14909276 0,18416753 ! iron ion homeostasis GO:0055072 16 16 0,000 0,14909276 0,18404418 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,14909276 0,18392099 ! cell fate specification GO:0001708 16 16 0,000 0,14909276 0,18379797 ! pentose metabolic process GO:0019321 16 16 0,000 0,14909276 0,18367511 ! fatty acid transport GO:0015908 16 16 0,000 0,14909276 0,18355241 ! cofactor catabolic process GO:0051187 16 16 0,000 0,14909276 0,18342988 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,14909276 0,18330751 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,14909276 0,18318531 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,14909276 0,18306326 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,14909276 0,18294139 GO:0033013|tetrapyrrole metabolic process, ! positive regulation of catabolic process GO:0009896 16 16 0,000 0,14909276 0,18281967 ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,14909276 0,18269811 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,14909276 0,18257672 ! regulation of coagulation GO:0050818 17 16 0,000 0,14909276 0,18245549 ! wound healing GO:0042060 74 70 1,000 0,15542987 0,19008444 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 0,000 0,15764646 0,19266739 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,15764646 0,19253972 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,15764646 0,19241221 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,15764646 0,19228486 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,15764646 0,19215769 ! sensory perception of smell GO:0007608 17 17 0,000 0,15764646 0,19203069 ! glucose transport GO:0015758 17 17 0,000 0,15764646 0,19190385 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,15764646 0,19177718 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,15764646 0,19165068 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,15764646 0,19152434 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,15764646 0,19139818 ! neural crest cell development GO:0014032 19 17 0,000 0,15764646 0,19127217 GO:0014033|neural crest cell differentiation, ! cell recognition GO:0008037 18 17 0,000 0,15764646 0,19114634 ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,15764646 0,19102066 ! regulation of osteoblast differentiation GO:0045667 17 17 0,000 0,15764646 0,19089516 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,15764646 0,19076982 ! adult locomotory behavior GO:0008344 17 17 0,000 0,15764646 0,19064464 ! embryonic organ development GO:0048568 17 17 0,000 0,15764646 0,19051963 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,15764646 0,19039478 ! liver development GO:0001889 17 17 0,000 0,15764646 0,19027009 ! gene silencing GO:0016458 17 17 0,000 0,15764646 0,19014557 ! translational elongation GO:0006414 71 71 1,000 0,15894982 0,19159223 ! muscle system process GO:0003012 72 72 1,000 0,16248492 0,1957253 ! sensory organ development GO:0007423 72 72 1,000 0,16248492 0,19559746 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,16611541 0,19983727 ! regulation of cellular catabolic process GO:0031329 18 18 0,000 0,16611541 0,19970692 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,16611541 0,19957673 ! meiosis I GO:0007127 18 18 0,000 0,16611541 0,19944671 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,16611541 0,19931686 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,16611541 0,19918718 ! response to calcium ion GO:0051592 18 18 0,000 0,16611541 0,19905767 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,16611541 0,19892833 ! hexose transport GO:0008645 18 18 0,000 0,16611541 0,19879916 GO:0015749|monosaccharide transport, ! cholesterol homeostasis GO:0042632 18 18 0,000 0,16611541 0,19867015 GO:0055092|sterol homeostasis, ! striated muscle contraction GO:0006941 18 18 0,000 0,16611541 0,19854131 ! neutral lipid metabolic process GO:0006638 18 18 0,000 0,16611541 0,19841264 GO:0006639|acylglycerol metabolic process, ! ceramide metabolic process GO:0006672 18 18 0,000 0,16611541 0,19828413 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,16611541 0,19815579 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,16611541 0,19802762 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,16611541 0,19789961 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,16611541 0,19777177 ! BMP signaling pathway GO:0030509 18 18 0,000 0,16611541 0,19764409 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 0,000 0,16611541 0,19751658 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,16611541 0,19738923 ! coenzyme metabolic process GO:0006732 75 74 1,000 0,16959802 0,20139765 ! response to oxidative stress GO:0006979 76 75 1,000 0,17317476 0,20551261 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,17450044 0,20695258 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,17450044 0,20681949 GO:0006956|complement activation, ! glial cell differentiation GO:0010001 19 19 0,000 0,17450044 0,20668657 ! regulation of JAK-STAT cascade GO:0046425 19 19 0,000 0,17450044 0,20655382 ! feeding behavior GO:0007631 19 19 0,000 0,17450044 0,20642125 ! peroxisome organization GO:0007031 19 19 0,000 0,17450044 0,20628884 ! multicellular organismal metabolic process GO:0044236 19 19 0,000 0,17450044 0,2061566 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,17450044 0,20602454 ! cellular response to oxidative stress GO:0034599 19 19 0,000 0,17450044 0,20589264 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,17450044 0,20576091 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,17450044 0,20562935 ! eye morphogenesis GO:0048592 19 19 0,000 0,17450044 0,20549796 ! placenta development GO:0001890 19 19 0,000 0,17450044 0,20536673 ! vesicle localization GO:0051648 20 19 0,000 0,17450044 0,20523567 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,18280235 0,21486272 ! organic ether metabolic process GO:0018904 20 20 0,000 0,18280235 0,21472577 GO:0006662|glycerol ether metabolic process, ! nucleus organization GO:0006997 20 20 0,000 0,18280235 0,21458901 ! phagocytosis GO:0006909 21 20 0,000 0,18280235 0,21445241 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,18280235 0,21431599 ! protein targeting to membrane GO:0006612 22 20 0,000 0,18280235 0,21417975 ! chromatin remodeling GO:0006338 20 20 0,000 0,18280235 0,21404367 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,18280235 0,21390777 ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,18280235 0,21377204 ! RNA modification GO:0009451 20 20 0,000 0,18280235 0,21363649 ! single fertilization GO:0007338 21 20 0,000 0,18280235 0,2135011 ! regulation of immune response GO:0050776 78 78 1,000 0,18397846 0,21473863 ! mRNA catabolic process GO:0006402 21 21 0,000 0,19102198 0,22281868 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,19102198 0,22267774 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,19102198 0,22253699 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,19102198 0,22239641 ! ear morphogenesis GO:0042471 21 21 0,000 0,19102198 0,222256 ! organic anion transport GO:0015711 21 21 0,000 0,19102198 0,22211578 ! cholesterol transport GO:0030301 21 21 0,000 0,19102198 0,22197573 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,19102198 0,22183586 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,19102198 0,22169617 GO:0032313|regulation of Rab GTPase activity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,19102198 0,22155665 ! regulation of proteolysis GO:0030162 21 21 0,000 0,19102198 0,2214173 ! cellular response to insulin stimulus GO:0032869 23 21 0,000 0,19102198 0,22127813 ! RNA export from nucleus GO:0006405 22 22 0,000 0,19916012 0,23056036 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,19916012 0,23041563 ! regulation of ion transport GO:0043269 22 22 0,000 0,19916012 0,23027108 ! odontogenesis GO:0042476 22 22 0,000 0,19916012 0,23012671 ! hormone-mediated signaling GO:0009755 22 22 0,000 0,19916012 0,22998252 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,19916012 0,22983851 ! spindle organization GO:0007051 22 22 0,000 0,19916012 0,22969468 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,19916012 0,22955103 ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,19916012 0,22940756 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,19916012 0,22926427 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,19916012 0,22912116 ! biopolymer methylation GO:0043414 22 22 0,000 0,19916012 0,22897823 GO:0032259|methylation, ! detection of external stimulus GO:0009581 23 22 0,000 0,19916012 0,22883547 ! neuron migration GO:0001764 22 22 0,000 0,19916012 0,2286929 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,19916012 0,2285505 ! aerobic respiration GO:0009060 22 22 0,000 0,19916012 0,22840828 ! cytokine production GO:0001816 22 22 0,000 0,19916012 0,22826623 ! cytokinesis GO:0000910 23 22 0,000 0,19916012 0,22812436 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,19916012 0,22798267 ! ncRNA processing GO:0034470 83 83 1,000 0,20219468 0,23131272 ! cellular amino acid derivative metabolic process GO:0006575 87 84 1,000 0,20586443 0,23536486 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,20721756 0,23676501 ! viral infectious cycle GO:0019058 23 23 0,000 0,20721756 0,23661832 ! regulation of hormone secretion GO:0046883 23 23 0,000 0,20721756 0,23647181 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,20721756 0,23632548 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,20721756 0,23617932 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,20721756 0,23603335 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,20721756 0,23588757 ! endocrine system development GO:0035270 23 23 0,000 0,20721756 0,23574196 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,20721756 0,23559653 ! lipid homeostasis GO:0055088 23 23 0,000 0,20721756 0,23545127 ! organophosphate metabolic process GO:0019637 87 86 1,000 0,21322623 0,24212935 GO:0006644|phospholipid metabolic process, ! gliogenesis GO:0042063 24 24 0,000 0,2151951 0,24421464 ! cellular amino acid biosynthetic process GO:0008652 24 24 0,000 0,2151951 0,24406435 ! glucose homeostasis GO:0042593 24 24 0,000 0,2151951 0,24391425 GO:0033500|carbohydrate homeostasis, ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,2151951 0,24376434 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,2151951 0,2436146 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,2151951 0,24346505 ! fertilization GO:0009566 25 24 0,000 0,2151951 0,24331569 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,2151951 0,24316651 ! male gamete generation GO:0048232 90 88 1,000 0,22061437 0,24913743 GO:0007283|spermatogenesis, ! purine nucleotide biosynthetic process GO:0006164 88 88 1,000 0,22061437 0,24898486 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,22309352 0,25162874 ! negative regulation of secretion GO:0051048 26 25 0,000 0,22309352 0,25147483 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,22309352 0,25132112 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,22309352 0,2511676 ! cellular component disassembly GO:0022411 26 25 0,000 0,22309352 0,25101426 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,22309352 0,25086111 ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,22309352 0,25070814 ! excretion GO:0007588 25 25 0,000 0,22309352 0,25055536 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,22309352 0,25040277 ! gastrulation GO:0007369 25 25 0,000 0,22309352 0,25025037 ! heart morphogenesis GO:0003007 25 25 0,000 0,22309352 0,25009815 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,22309352 0,24994611 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,22309352 0,24979426 ! positive regulation of cytokine production GO:0001819 25 25 0,000 0,22309352 0,24964259 ! brain development GO:0007420 91 90 1,000 0,22802494 0,25500605 ! positive regulation of defense response GO:0031349 26 26 0,000 0,23091358 0,25807989 ! glycolysis GO:0006096 26 26 0,000 0,23091358 0,25792347 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,23091358 0,25776725 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,23091358 0,25761122 ! cellular defense response GO:0006968 26 26 0,000 0,23091358 0,25745537 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,23091358 0,25729972 ! regulation of protein secretion GO:0050708 26 26 0,000 0,23091358 0,25714425 ! response to insulin stimulus GO:0032868 28 26 0,000 0,23091358 0,25698897 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 1,000 0,23545418 0,26188416 ! chloride transport GO:0006821 27 27 0,000 0,23865606 0,26528536 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,23865606 0,26512545 ! learning or memory GO:0007611 28 27 0,000 0,23865606 0,26496574 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,23865606 0,26480622 ! inner ear development GO:0048839 27 27 0,000 0,23865606 0,26464689 ! defense response to bacterium GO:0042742 27 27 0,000 0,23865606 0,26448775 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,23865606 0,2643288 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,23865606 0,26417005 ! regulation of response to stress GO:0080134 97 94 1,000 0,24289844 0,26870458 ! cofactor metabolic process GO:0051186 95 94 1,000 0,24289844 0,26854339 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,24632172 0,27216482 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! neuromuscular process GO:0050905 28 28 0,000 0,24632172 0,27200175 ! carbohydrate transport GO:0008643 28 28 0,000 0,24632172 0,27183888 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,24632172 0,2716762 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,24632172 0,27151371 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,24632172 0,27135142 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,2539113 0,27954512 ! viral reproductive process GO:0022415 29 29 0,000 0,2539113 0,27937822 ! antigen processing and presentation GO:0019882 29 29 0,000 0,2539113 0,27921153 ! tRNA processing GO:0008033 29 29 0,000 0,2539113 0,27904503 ! regulation of gene expression, epigenetic GO:0040029 29 29 0,000 0,2539113 0,27887874 ! adult behavior GO:0030534 30 29 0,000 0,2539113 0,27871264 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,2539113 0,27854674 ! endocytosis GO:0006897 99 98 1,000 0,25781818 0,28266443 GO:0010324|membrane invagination, ! transition metal ion transport GO:0000041 31 30 0,000 0,26142555 0,28644904 ! RNA catabolic process GO:0006401 30 30 0,000 0,26142555 0,28627884 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,26142555 0,28610884 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,26142555 0,28593904 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,26142555 0,28576944 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,26142555 0,28560005 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,26142555 0,28543086 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,26142555 0,28526186 GO:0019724|B cell mediated immunity, ! regulation of inflammatory response GO:0050727 30 30 0,000 0,26142555 0,28509307 ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,26142555 0,28492447 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,26142555 0,28475608 ! establishment of organelle localization GO:0051656 31 30 0,000 0,26142555 0,28458788 ! anti-apoptosis GO:0006916 100 99 1,000 0,26155219 0,28455766 ! response to hormone stimulus GO:0009725 102 100 1,000 0,26528703 0,28845074 ! regulation of translational initiation GO:0006446 31 31 0,000 0,2688652 0,29216897 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,2688652 0,2919968 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,2688652 0,29182483 ! ion transmembrane transport GO:0034220 31 31 0,000 0,2688652 0,29165307 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,2688652 0,29148151 ! digestion GO:0007586 31 31 0,000 0,2688652 0,29131015 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,2688652 0,29113899 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,2688652 0,29096804 ! camera-type eye development GO:0043010 31 31 0,000 0,2688652 0,29079728 ! extracellular matrix organization GO:0030198 31 31 0,000 0,2688652 0,29062673 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,2688652 0,29045637 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,2688652 0,29028621 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,2688652 0,29011626 ! cell redox homeostasis GO:0045454 32 32 0,000 0,27623099 0,29788983 ! glucose catabolic process GO:0006007 32 32 0,000 0,27623099 0,29771563 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,27623099 0,29754163 ! cell maturation GO:0048469 32 32 0,000 0,27623099 0,29736783 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,27623099 0,29719423 ! amino acid transport GO:0006865 33 33 0,000 0,28352364 0,30486235 ! activation of protein kinase activity GO:0032147 35 33 0,000 0,28352364 0,30468459 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,28352364 0,30450704 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,28352364 0,30432969 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,28352364 0,30415255 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,28352364 0,30397561 ! regulation of actin filament length GO:0030832 34 34 0,000 0,29074387 0,31153543 ! muscle cell differentiation GO:0042692 35 34 0,000 0,29074387 0,31135441 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,29074387 0,3111736 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,29074387 0,310993 ! viral reproduction GO:0016032 34 34 0,000 0,29074387 0,31081261 ! detection of stimulus GO:0051606 36 34 0,000 0,29074387 0,31063243 ! acute inflammatory response GO:0002526 35 35 0,000 0,29789237 0,31808554 ! regulation of cellular component size GO:0032535 35 35 0,000 0,29789237 0,31790136 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,29789237 0,31771739 ! inorganic anion transport GO:0015698 35 35 0,000 0,29789237 0,31753363 ! hydrogen transport GO:0006818 36 36 0,000 0,30496986 0,32488986 GO:0015992|proton transport, ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,30496986 0,32470217 ! embryonic limb morphogenesis GO:0030326 36 36 0,000 0,30496986 0,3245147 GO:0035113|embryonic appendage morphogenesis, ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,30496986 0,32432744 ! positive regulation of organelle organization GO:0010638 36 36 0,000 0,30496986 0,3241404 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,30496986 0,32395358 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,30496986 0,32376697 ! coagulation GO:0050817 39 36 0,000 0,30496986 0,32358057 GO:0007596|blood coagulation, ! meiosis GO:0007126 37 37 0,000 0,31197703 0,3308249 GO:0051327|M phase of meiotic cell cycle, ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,31197703 0,33063466 ! eye development GO:0001654 37 37 0,000 0,31197703 0,33044464 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,31197703 0,33025484 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,31197703 0,33006525 ! regulation of Rho protein signal transduction GO:0035023 37 37 0,000 0,31197703 0,32987589 ! positive regulation of secretion GO:0051047 39 38 0,000 0,31891457 0,3370181 ! neurotransmitter transport GO:0006836 40 38 0,000 0,31891457 0,33682496 ! hexose catabolic process GO:0019320 38 38 0,000 0,31891457 0,33663205 ! RNA elongation GO:0006354 38 38 0,000 0,31891457 0,33643936 ! meiotic cell cycle GO:0051321 38 38 0,000 0,31891457 0,33624689 ! regulation of neurological system process GO:0031644 38 38 0,000 0,31891457 0,33605464 ! hemostasis GO:0007599 42 39 0,000 0,32578316 0,34309621 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,32578316 0,34290027 ! response to unfolded protein GO:0006986 39 39 0,000 0,32578316 0,34270455 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,32578316 0,34250905 ! developmental maturation GO:0021700 39 39 0,000 0,32578316 0,34231378 ! limb development GO:0060173 39 39 0,000 0,32578316 0,34211873 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! DNA catabolic process GO:0006308 41 40 0,000 0,33258348 0,34906114 ! myeloid cell differentiation GO:0030099 42 40 0,000 0,33258348 0,34886247 ! organelle localization GO:0051640 41 40 0,000 0,33258348 0,34866402 ! amine catabolic process GO:0009310 42 41 0,000 0,33931619 0,35552003 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,33931619 0,35531803 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,33931619 0,35511626 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,33931619 0,35491472 ! monosaccharide catabolic process GO:0046365 41 41 0,000 0,33931619 0,35471341 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,34598196 0,36147661 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,34598196 0,36127181 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! forebrain development GO:0030900 43 42 0,000 0,34598196 0,36106724 ! one-carbon metabolic process GO:0006730 42 42 0,000 0,34598196 0,3608629 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 0,000 0,34598196 0,36065879 ! alcohol catabolic process GO:0046164 43 43 0,000 0,35258144 0,36733046 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 0,000 0,35911528 0,37392625 ! negative regulation of organelle organization GO:0010639 45 44 0,000 0,35911528 0,37371511 ! vitamin metabolic process GO:0006766 44 44 0,000 0,35911528 0,37350421 ! amine biosynthetic process GO:0009309 46 45 0,000 0,36558413 0,38001779 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,36558413 0,37980358 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 0,000 0,36558413 0,37958961 ! protein processing GO:0016485 45 45 0,000 0,36558413 0,37937587 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,37198862 0,38580474 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 0,000 0,37198862 0,38558775 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,37198862 0,38537101 ! positive regulation of ligase activity GO:0051351 47 46 0,000 0,37198862 0,38515451 ! cellular response to hormone stimulus GO:0032870 48 46 0,000 0,37198862 0,38493825 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,37832938 0,39128005 ! amine transport GO:0015837 47 47 0,000 0,37832938 0,3910606 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 0,000 0,38460705 0,39732667 ! DNA recombination GO:0006310 48 48 0,000 0,38460705 0,39710408 ! response to bacterium GO:0009617 50 49 0,000 0,39082223 0,40329528 ! regulation of ligase activity GO:0051340 50 49 0,000 0,39082223 0,40306959 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,39082223 0,40284416 ! regulation of defense response GO:0031347 50 50 0,000 0,39697554 0,40895803 ! chromatin assembly GO:0031497 50 50 0,000 0,39697554 0,40872956 GO:0006334|nucleosome assembly, ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,39697554 0,40850135 ! transcription initiation GO:0006352 50 50 0,000 0,39697554 0,40827339 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,40306759 0,41430762 ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,40306759 0,41407668 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,40306759 0,413846 ! protein maturation GO:0051604 51 51 0,000 0,40306759 0,41361557 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,40909897 0,41957118 ! regulation of body fluid levels GO:0050878 55 52 0,000 0,40909897 0,41933782 ! sodium ion transport GO:0006814 53 53 0,000 0,41507029 0,4252221 ! tRNA metabolic process GO:0006399 53 53 0,000 0,41507029 0,42498586 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,41507029 0,42474989 ! carbohydrate catabolic process GO:0016052 53 53 0,000 0,41507029 0,42451418 ! nucleosome organization GO:0034728 55 55 0,000 0,42683508 0,43630453 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,42683508 0,43606267 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,43262972 0,44173771 ! ATP metabolic process GO:0046034 57 57 0,000 0,43836661 0,44734754 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,43836661 0,44709998 ! innate immune response GO:0045087 58 58 0,000 0,44404633 0,45264236 ! carboxylic acid transport GO:0046942 59 59 0,000 0,44966943 0,45812093 GO:0015849|organic acid transport, ! sterol metabolic process GO:0016125 59 59 0,000 0,44966943 0,45786782 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,44966943 0,457615 ! potassium ion transport GO:0006813 60 60 0,000 0,45523647 0,46302474 ! protein polymerization GO:0051258 65 60 0,000 0,45523647 0,46276934 ! cellular respiration GO:0045333 62 61 0,000 0,46074801 0,46811388 ! proteasomal protein catabolic process GO:0010498 62 61 0,000 0,46074801 0,46785597 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 0,000 0,46074801 0,46759834 ! lipid transport GO:0006869 62 62 0,000 0,46620459 0,47287565 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,46620459 0,47261554 ! regulation of secretion GO:0051046 65 63 0,000 0,47160674 0,47782915 ! glucose metabolic process GO:0006006 63 63 0,000 0,47160674 0,47756661 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,47160674 0,47730435 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,47160674 0,47704238 ! positive regulation of protein metabolic process GO:0051247 64 64 0,000 0,47695501 0,48218765 ! anion transport GO:0006820 65 65 0,000 0,48224992 0,48727335 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,48749199 0,49230013 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,48749199 0,49203053 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,49268176 0,49699643 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,49781972 0,50190468 ! regulation of translation GO:0006417 69 69 0,000 0,5029064 0,50675587 ! sensory perception of sound GO:0007605 71 69 0,000 0,5029064 0,50647896 GO:0050954|sensory perception of mechanical stimulus, ! carboxylic acid biosynthetic process GO:0046394 70 70 0,000 0,50794229 0,51127124 GO:0016053|organic acid biosynthetic process, ! oxidative phosphorylation GO:0006119 71 71 0,000 0,5129279 0,5160077 ! regulation of cytokine production GO:0001817 72 72 0,000 0,51786371 0,52068894 ! electron transport chain GO:0022900 75 74 0,000 0,52758793 0,53017697 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,5323773 0,53469829 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,5323773 0,53440706 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,55561561 0,55743036 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,56900835 0,57055625 ! nitrogen compound biosynthetic process GO:0044271 86 85 0,000 0,57771502 0,57897161 ! hexose metabolic process GO:0019318 87 86 0,000 0,58200313 0,58295205 ! regulation of Ras protein signal transduction GO:0046578 90 90 0,000 0,59873057 0,59938101 ! visual perception GO:0007601 93 92 0,000 0,60684513 0,60717457 GO:0050953|sensory perception of light stimulus, ! glycoprotein metabolic process GO:0009100 99 98 0,000 0,63023087 0,63023087