pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6311-Loi-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of protein stability GO:0031647 73 37 8,000 7,802E-12 1,877E-08 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 4,000 1,483E-10 1,784E-07 ! negative regulation of phosphorylation GO:0042326 47 24 6,000 4,285E-10 3,436E-07 ! negative regulation of phosphorus metabolic process GO:0010563 51 26 6,000 8,038E-10 4,835E-07 GO:0045936|negative regulation of phosphate metabolic process, ! platelet-derived growth factor receptor signaling pathway GO:0048008 28 17 5,000 2,144E-09 1,032E-06 ! regulation of protein kinase B signaling cascade GO:0051896 26 10 4,000 6,075E-09 2,436E-06 ! negative regulation of cell-matrix adhesion GO:0001953 36 11 4,000 1,107E-08 3,804E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of cyclin-dependent protein kinase activity GO:0000079 102 57 7,000 1,226E-08 3,689E-06 ! phospholipid dephosphorylation GO:0046839 12 5 3,000 1,647E-08 4,403E-06 ! regulation of cell-matrix adhesion GO:0001952 78 23 5,000 1,683E-08 4,049E-06 GO:0010810|regulation of cell-substrate adhesion, ! negative regulation of protein amino acid phosphorylation GO:0001933 32 14 4,000 4,707E-08 1,03E-05 ! negative regulation of cell migration GO:0030336 115 46 6,000 5,745E-08 1,152E-05 ! negative regulation of protein modification process GO:0031400 60 28 5,000 6,083E-08 1,126E-05 ! negative regulation of focal adhesion formation GO:0051895 20 7 3,000 1,139E-07 1,958E-05 ! endothelial cell migration GO:0043542 28 17 4,000 1,428E-07 2,291E-05 ! negative regulation of cell motion GO:0051271 134 55 6,000 2,055E-07 3,09E-05 ! regulation of focal adhesion formation GO:0051893 22 8 3,000 2,265E-07 3,205E-05 ! negative regulation of cell adhesion GO:0007162 81 35 5,000 2,507E-07 3,35E-05 ! lipid modification GO:0030258 97 57 6,000 2,642E-07 3,346E-05 ! apoptotic mitochondrial changes GO:0008637 41 20 4,000 3,512E-07 4,225E-05 ! induction of positive chemotaxis GO:0050930 15 9 3,000 4,052E-07 4,642E-05 ! regulation of cell adhesion GO:0030155 212 89 7,000 4,25E-07 4,648E-05 ! positive regulation of locomotion GO:0040017 39 21 4,000 4,58E-07 4,792E-05 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 40 22 4,000 5,891E-07 5,906E-05 ! regulation of insulin receptor signaling pathway GO:0046626 19 10 3,000 6,713E-07 6,46E-05 ! negative regulation of protein kinase activity GO:0006469 130 67 6,000 8,147E-07 7,539E-05 ! negative regulation of kinase activity GO:0033673 131 68 6,000 9,023E-07 8,041E-05 ! regulation of behavior GO:0050795 43 24 4,000 9,39E-07 8,069E-05 ! negative regulation of transferase activity GO:0051348 140 72 6,000 1,336E-06 1,109E-04 ! regulation of B cell proliferation GO:0030888 20 12 3,000 1,563E-06 1,254E-04 ! regulation of positive chemotaxis GO:0050926 19 12 3,000 1,563E-06 1,213E-04 GO:0050927|positive regulation of positive chemotaxis, ! negative regulation of protein kinase cascade GO:0010741 68 30 4,000 3,033E-06 2,28E-04 ! actin cytoskeleton reorganization GO:0031532 33 14 3,000 3,124E-06 2,277E-04 ! release of cytochrome c from mitochondria GO:0001836 30 14 3,000 3,124E-06 2,21E-04 ! response to UV GO:0009411 104 53 5,000 3,161E-06 2,173E-04 ! regulation of the force of heart contraction GO:0002026 26 15 3,000 4,234E-06 2,83E-04 ! regulation of mitochondrial membrane permeability GO:0046902 14 5 2,000 4,347E-06 2,827E-04 ! traversing start control point of mitotic cell cycle GO:0007089 12 5 2,000 4,347E-06 2,752E-04 ! positive regulation of cell migration GO:0030335 126 57 5,000 4,871E-06 3,005E-04 ! inositol metabolic process GO:0006020 28 17 3,000 7,294E-06 4,388E-04 ! cardiac muscle tissue development GO:0048738 31 17 3,000 7,294E-06 4,281E-04 ! neutrophil chemotaxis GO:0030593 27 17 3,000 7,294E-06 4,179E-04 ! interphase of mitotic cell cycle GO:0051329 209 95 6,000 8,638E-06 4,833E-04 ! positive regulation of cell motion GO:0051272 146 64 5,000 9,626E-06 5,264E-04 ! interphase GO:0051325 213 98 6,000 1,061E-05 5,671E-04 ! mitotic chromosome condensation GO:0007076 34 19 3,000 1,174E-05 6,139E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 114 67 5,000 1,257E-05 6,435E-04 ! negative regulation of binding GO:0051100 72 40 4,000 1,316E-05 6,596E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 15 7 2,000 1,504E-05 7,386E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 1,504E-05 7,239E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 1,504E-05 7,097E-04 ! positive regulation of response to external stimulus GO:0032103 77 43 4,000 1,89E-05 8,743E-04 ! protein stabilization GO:0050821 39 22 3,000 2,176E-05 9,877E-04 ! leukocyte migration GO:0050900 68 45 4,000 2,369E-05 1,055E-03 ! induction of apoptosis by intracellular signals GO:0008629 93 45 4,000 2,369E-05 1,036E-03 ! ER overload response GO:0006983 12 8 2,000 2,393E-05 1,028E-03 ! regulation of T cell differentiation in the thymus GO:0033081 13 8 2,000 2,393E-05 1,01E-03 ! phosphoinositide 3-kinase cascade GO:0014065 32 8 2,000 2,393E-05 9,928E-04 ! G1/S transition of mitotic cell cycle GO:0000082 115 46 4,000 2,641E-05 1,077E-03 ! regulation of mast cell proliferation GO:0070666 81 48 4,000 3,259E-05 1,307E-03 ! T cell selection GO:0045058 23 9 2,000 3,57E-05 1,408E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 24 9 2,000 3,57E-05 1,385E-03 ! chromosome condensation GO:0030261 45 25 3,000 3,695E-05 1,411E-03 ! regulation of leukocyte proliferation GO:0070663 88 51 4,000 4,388E-05 1,65E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 20 10 2,000 5,071E-05 1,877E-03 ! positive regulation of B cell proliferation GO:0030890 16 10 2,000 5,071E-05 1,849E-03 ! positive regulation of leukocyte migration GO:0002687 25 10 2,000 5,071E-05 1,821E-03 ! regulation of DNA replication GO:0006275 101 56 4,000 6,918E-05 2,448E-03 ! chondrocyte differentiation GO:0002062 24 11 2,000 6,933E-05 2,417E-03 ! regulation of leukocyte migration GO:0002685 26 11 2,000 6,933E-05 2,383E-03 ! negative regulation of glucose import GO:0046325 17 11 2,000 6,933E-05 2,349E-03 GO:0010829|negative regulation of glucose transport, ! regulation of B cell activation GO:0050864 50 30 3,000 7,769E-05 2,596E-03 ! positive regulation of MAP kinase activity GO:0043406 160 93 5,000 8,142E-05 2,683E-03 ! integrin-mediated signaling pathway GO:0007229 135 59 4,000 8,899E-05 2,894E-03 ! negative regulation of mast cell proliferation GO:0070667 23 12 2,000 9,192E-05 2,949E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of DNA metabolic process GO:0051052 178 97 5,000 1,029E-04 3,258E-03 ! leukocyte chemotaxis GO:0030595 50 33 3,000 1,139E-04 3,56E-03 GO:0060326|cell chemotaxis, ! ribosomal large subunit biogenesis GO:0042273 13 13 2,000 1,188E-04 3,665E-03 ! cytoplasmic sequestering of protein GO:0051220 24 13 2,000 1,188E-04 3,619E-03 ! T cell differentiation in the thymus GO:0033077 31 14 2,000 1,504E-04 4,522E-03 ! response to gamma radiation GO:0010332 28 14 2,000 1,504E-04 4,467E-03 ! mitotic sister chromatid segregation GO:0000070 57 36 3,000 1,611E-04 4,727E-03 ! negative regulation of cell growth GO:0030308 132 67 4,000 1,634E-04 4,736E-03 ! sister chromatid segregation GO:0000819 58 37 3,000 1,796E-04 5,143E-03 ! negative regulation of DNA binding GO:0043392 68 37 3,000 1,796E-04 5,083E-03 ! negative regulation of bone remodeling GO:0046851 33 15 2,000 1,869E-04 5,229E-03 ! negative regulation of cell size GO:0045792 134 69 4,000 1,878E-04 5,193E-03 ! G1 phase of mitotic cell cycle GO:0000080 35 16 2,000 2,287E-04 6,254E-03 ! negative regulation of tissue remodeling GO:0034104 36 16 2,000 2,287E-04 6,184E-03 ! negative regulation of leukocyte proliferation GO:0070664 31 16 2,000 2,287E-04 6,115E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 37 16 2,000 2,287E-04 6,048E-03 ! phosphoinositide metabolic process GO:0030384 128 72 4,000 2,295E-04 6,002E-03 ! regulation of T cell proliferation GO:0042129 71 41 3,000 2,688E-04 6,955E-03 ! T cell differentiation GO:0030217 81 41 3,000 2,688E-04 6,881E-03 ! regulation of T cell differentiation GO:0045580 70 41 3,000 2,688E-04 6,808E-03 ! polyol metabolic process GO:0019751 66 41 3,000 2,688E-04 6,737E-03 ! negative regulation of protein catabolic process GO:0042177 40 17 2,000 2,762E-04 6,851E-03 ! regulation of protein binding GO:0043393 33 17 2,000 2,762E-04 6,781E-03 ! negative regulation of homeostatic process GO:0032845 33 17 2,000 2,762E-04 6,712E-03 ! cell-matrix adhesion GO:0007160 163 75 4,000 2,779E-04 6,686E-03 ! regulation of intracellular protein transport GO:0033157 80 42 3,000 2,954E-04 7,036E-03 ! response to retinoic acid GO:0032526 26 18 2,000 3,296E-04 7,774E-03 ! peptidyl-serine phosphorylation GO:0018105 38 18 2,000 3,296E-04 7,699E-03 ! response to vitamin A GO:0033189 27 19 2,000 3,892E-04 9,003E-03 ! plasma membrane fusion GO:0045026 28 19 2,000 3,892E-04 8,918E-03 ! G1 phase GO:0051318 40 19 2,000 3,892E-04 8,833E-03 ! T cell activation GO:0042110 168 81 4,000 3,975E-04 8,939E-03 ! cell-substrate adhesion GO:0031589 171 81 4,000 3,975E-04 8,856E-03 ! pigmentation GO:0043473 100 46 3,000 4,205E-04 9,281E-03 ! regulation of nucleocytoplasmic transport GO:0046822 85 46 3,000 4,205E-04 9,196E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 35 20 2,000 4,553E-04 9,868E-03 ! response to vitamin GO:0033273 31 20 2,000 4,553E-04 9,78E-03 ! fatty acid beta-oxidation GO:0006635 34 20 2,000 4,553E-04 9,694E-03 ! peptidyl-serine modification GO:0018209 43 20 2,000 4,553E-04 9,609E-03 ! regulation of glucose import GO:0046324 29 20 2,000 4,553E-04 9,525E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 40 20 2,000 4,553E-04 9,443E-03 ! negative regulation of transport GO:0051051 153 84 4,000 4,702E-04 9,67E-03 ! negative regulation of growth GO:0045926 155 84 4,000 4,702E-04 9,588E-03 ! activation of caspase activity GO:0006919 84 48 3,000 4,954E-04 0,01001618 ! regulation of lymphocyte differentiation GO:0045619 81 48 3,000 4,954E-04 9,933E-03 ! mitochondrion organization GO:0007005 148 86 4,000 5,239E-04 0,01041823 ! inactivation of MAPK activity GO:0000188 39 21 2,000 5,282E-04 0,01041615 ! cell structure disassembly during apoptosis GO:0006921 30 21 2,000 5,282E-04 0,01033147 ! cell aging GO:0007569 44 21 2,000 5,282E-04 0,01024815 ! regulation of vasoconstriction GO:0019229 39 21 2,000 5,282E-04 0,01016616 ! positive regulation of inflammatory response GO:0050729 35 21 2,000 5,282E-04 0,01008548 ! negative regulation of protein ubiquitination GO:0031397 9 5 1,000 5,72E-04 0,01083571 ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,72E-04 0,01075106 ! negative regulation of cell-cell adhesion GO:0022408 12 5 1,000 5,72E-04 0,01066772 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 1,000 5,72E-04 0,01058566 ! epithelial cell proliferation GO:0050673 9 5 1,000 5,72E-04 0,01050485 ! microvillus organization GO:0032528 7 5 1,000 5,72E-04 0,01042527 GO:0030033|microvillus assembly, ! positive regulation of filopodium assembly GO:0051491 14 5 1,000 5,72E-04 0,01034688 GO:0051489|regulation of filopodium assembly, ! regulation of phospholipase A2 activity GO:0032429 13 5 1,000 5,72E-04 0,01026967 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 5,72E-04 0,0101936 ! early endosome to late endosome transport GO:0045022 12 5 1,000 5,72E-04 0,01011864 ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 5,72E-04 0,01004479 ! negative regulation of T cell mediated immunity GO:0002710 12 5 1,000 5,72E-04 9,972E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 14 5 1,000 5,72E-04 9,9E-03 ! B cell homeostasis GO:0001782 13 5 1,000 5,72E-04 9,83E-03 ! metaphase GO:0051323 8 5 1,000 5,72E-04 9,76E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 13 5 1,000 5,72E-04 9,691E-03 ! regulation of mitochondrial depolarization GO:0051900 13 5 1,000 5,72E-04 9,623E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 5,72E-04 9,556E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 5,72E-04 9,491E-03 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 1,000 5,72E-04 9,426E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! stem cell division GO:0017145 11 5 1,000 5,72E-04 9,361E-03 GO:0048103|somatic stem cell division, ! cellular anion homeostasis GO:0030002 9 5 1,000 5,72E-04 9,298E-03 GO:0055081|anion homeostasis, ! negative regulation of immune system process GO:0002683 95 50 3,000 5,794E-04 9,356E-03 ! regulation of DNA binding GO:0051101 155 88 4,000 5,822E-04 9,338E-03 ! positive regulation of epithelial cell proliferation GO:0050679 64 22 2,000 6,081E-04 9,69E-03 ! positive regulation of intracellular transport GO:0032388 37 22 2,000 6,081E-04 9,626E-03 ! positive regulation of B cell activation GO:0050871 38 22 2,000 6,081E-04 9,563E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 61 22 2,000 6,081E-04 9,501E-03 ! epithelial tube morphogenesis GO:0060562 98 51 3,000 6,25E-04 9,701E-03 ! regulation of cell cycle process GO:0010564 149 90 4,000 6,451E-04 9,949E-03 ! regulation of angiogenesis GO:0045765 114 52 3,000 6,73E-04 0,01031404 ! regulation of muscle contraction GO:0006937 81 52 3,000 6,73E-04 0,01024876 ! membrane fusion GO:0006944 110 52 3,000 6,73E-04 0,01018431 ! cartilage development GO:0051216 90 52 3,000 6,73E-04 0,01012066 ! negative regulation of catabolic process GO:0009895 50 23 2,000 6,954E-04 0,01039241 ! negative regulation of multicellular organismal process GO:0051241 166 93 4,000 7,489E-04 0,01112217 ! lymphocyte proliferation GO:0046651 48 24 2,000 7,903E-04 0,01166546 ! positive regulation of caspase activity GO:0043280 95 55 3,000 8,329E-04 0,01221868 GO:0010952|positive regulation of peptidase activity, ! regulation of protein catabolic process GO:0042176 116 55 3,000 8,329E-04 0,01214463 ! aging GO:0007568 103 55 3,000 8,329E-04 0,01207147 ! thymic T cell selection GO:0045061 12 6 1,000 8,536E-04 0,01229823 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 1,000 8,536E-04 0,01222502 ! vascular smooth muscle contraction GO:0014829 13 6 1,000 8,536E-04 0,01215269 ! establishment of spindle localization GO:0051293 12 6 1,000 8,536E-04 0,0120812 GO:0051653|spindle localization, ! monocyte differentiation GO:0030224 12 6 1,000 8,536E-04 0,01201055 ! neural nucleus development GO:0048857 14 6 1,000 8,536E-04 0,01194072 ! regulation of myeloid cell apoptosis GO:0033032 13 6 1,000 8,536E-04 0,0118717 ! negative regulation of neuroblast proliferation GO:0007406 21 6 1,000 8,536E-04 0,01180347 ! progesterone metabolic process GO:0042448 10 6 1,000 8,536E-04 0,01173602 ! cytoplasmic microtubule organization GO:0031122 14 6 1,000 8,536E-04 0,01166934 ! negative regulation of B cell activation GO:0050869 13 6 1,000 8,536E-04 0,01160341 ! leukocyte differentiation GO:0002521 202 96 4,000 8,646E-04 0,01168727 ! G2/M transition of mitotic cell cycle GO:0000086 43 25 2,000 8,93E-04 0,01200356 ! negative regulation of DNA replication GO:0008156 42 25 2,000 8,93E-04 0,01193688 ! response to endoplasmic reticulum stress GO:0034976 43 25 2,000 8,93E-04 0,01187093 ! neural tube closure GO:0001843 49 25 2,000 8,93E-04 0,0118057 GO:0060606|tube closure, ! regulation of protein localization GO:0032880 176 97 4,000 9,06E-04 0,01191223 ! regulation of intracellular transport GO:0032386 101 57 3,000 9,532E-04 0,01246426 ! tube lumen formation GO:0035148 50 26 2,000 1,004E-03 0,01305552 ! regulation of transcription factor import into nucleus GO:0042990 54 26 2,000 1,004E-03 0,01298533 ! leukocyte proliferation GO:0070661 52 26 2,000 1,004E-03 0,01291589 GO:0032943|mononuclear cell proliferation, ! cell cycle arrest GO:0007050 213 100 4,000 1,039E-03 0,01329837 ! skeletal system morphogenesis GO:0048705 105 59 3,000 1,085E-03 0,01381595 ! regulation of fibroblast proliferation GO:0048145 52 27 2,000 1,123E-03 0,01422076 ! epidermal growth factor receptor signaling pathway GO:0007173 61 27 2,000 1,123E-03 0,01414631 ! mitochondrial membrane organization GO:0007006 57 27 2,000 1,123E-03 0,01407263 ! primary neural tube formation GO:0014020 51 27 2,000 1,123E-03 0,01399971 ! negative regulation of lymphocyte activation GO:0051250 53 27 2,000 1,123E-03 0,01392755 ! regulation of heart contraction GO:0008016 110 60 3,000 1,156E-03 0,0142623 ! protein amino acid autophosphorylation GO:0046777 141 60 3,000 1,156E-03 0,01418953 ! negative regulation of response to stimulus GO:0048585 100 60 3,000 1,156E-03 0,0141175 ! regulation of helicase activity GO:0051095 15 7 1,000 1,189E-03 0,01444873 ! prostate gland development GO:0030850 13 7 1,000 1,189E-03 0,01437612 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,189E-03 0,01430424 ! N-terminal protein amino acid acetylation GO:0006474 13 7 1,000 1,189E-03 0,01423308 ! mRNA stabilization GO:0048255 18 7 1,000 1,189E-03 0,01416261 GO:0043489|RNA stabilization, ! positive regulation of isotype switching GO:0045830 15 7 1,000 1,189E-03 0,01409285 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 10 7 1,000 1,189E-03 0,01402377 ! phasic smooth muscle contraction GO:0014821 12 7 1,000 1,189E-03 0,01395536 ! organ growth GO:0035265 15 7 1,000 1,189E-03 0,01388761 ! G1 DNA damage checkpoint GO:0031571 21 7 1,000 1,189E-03 0,01382052 ! fibrinolysis GO:0042730 10 7 1,000 1,189E-03 0,01375408 ! positive regulation of immunoglobulin mediated immune response GO:0002891 13 7 1,000 1,189E-03 0,01368827 GO:0002714|positive regulation of B cell mediated immunity, ! response to tumor cell GO:0002347 13 7 1,000 1,189E-03 0,01362309 ! peptidyl-threonine modification GO:0018210 25 7 1,000 1,189E-03 0,01355852 ! positive regulation of leukocyte chemotaxis GO:0002690 16 7 1,000 1,189E-03 0,01349457 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 1,189E-03 0,01343121 ! regulation of T cell mediated cytotoxicity GO:0001914 17 7 1,000 1,189E-03 0,01336845 ! positive regulation of smooth muscle contraction GO:0045987 10 7 1,000 1,189E-03 0,01330627 ! ER-nuclear signaling pathway GO:0006984 48 28 2,000 1,251E-03 0,01393156 ! lipid oxidation GO:0034440 43 28 2,000 1,251E-03 0,01386736 GO:0019395|fatty acid oxidation, ! regulation of homeostatic process GO:0032844 134 62 3,000 1,307E-03 0,01442198 ! cellular response to extracellular stimulus GO:0031668 48 29 2,000 1,387E-03 0,01524031 ! regulation of microtubule cytoskeleton organization GO:0070507 70 29 2,000 1,387E-03 0,01517104 ! cell junction assembly GO:0034329 78 30 2,000 1,533E-03 0,01668645 ! negative regulation of leukocyte activation GO:0002695 56 30 2,000 1,533E-03 0,01661129 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 22 8 1,000 1,577E-03 0,01701915 ! oligopeptide transport GO:0006857 15 8 1,000 1,577E-03 0,01694317 ! macrophage chemotaxis GO:0048246 12 8 1,000 1,577E-03 0,01686787 ! T-helper 1 type immune response GO:0042088 12 8 1,000 1,577E-03 0,01679323 ! inositol phosphate-mediated signaling GO:0048016 11 8 1,000 1,577E-03 0,01671925 ! pigment granule organization GO:0048753 16 8 1,000 1,577E-03 0,01664592 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,577E-03 0,01657323 ! regulation of pigmentation during development GO:0048070 24 8 1,000 1,577E-03 0,01650117 ! melanin metabolic process GO:0006582 15 8 1,000 1,577E-03 0,01642974 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,577E-03 0,01635892 ! macrophage activation GO:0042116 12 8 1,000 1,577E-03 0,01628871 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,577E-03 0,0162191 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,577E-03 0,01615009 ! response to UV-B GO:0010224 16 8 1,000 1,577E-03 0,01608165 ! B cell receptor signaling pathway GO:0050853 16 8 1,000 1,577E-03 0,0160138 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 14 8 1,000 1,577E-03 0,01594651 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 1,577E-03 0,01587979 ! fatty acid catabolic process GO:0009062 48 31 2,000 1,687E-03 0,0169165 ! negative regulation of transcription regulator activity GO:0090048 58 31 2,000 1,687E-03 0,0168463 GO:0043433|negative regulation of transcription factor activity, ! chromosome segregation GO:0007059 113 67 3,000 1,743E-03 0,01732851 ! response to ionizing radiation GO:0010212 65 32 2,000 1,852E-03 0,01833285 ! regulation of protein import into nucleus GO:0042306 63 32 2,000 1,852E-03 0,01825772 ! negative regulation of MAP kinase activity GO:0043407 69 32 2,000 1,852E-03 0,0181832 ! cell cycle checkpoint GO:0000075 137 69 3,000 1,943E-03 0,01900001 ! urogenital system development GO:0001655 137 69 3,000 1,943E-03 0,01892309 ! cytoplasmic sequestering of transcription factor GO:0042994 14 9 1,000 2,018E-03 0,01957699 ! microtubule bundle formation GO:0001578 21 9 1,000 2,018E-03 0,01949837 ! receptor clustering GO:0043113 18 9 1,000 2,018E-03 0,01942038 ! behavioral fear response GO:0001662 22 9 1,000 2,018E-03 0,01934301 GO:0002209|behavioral defense response, ! motor axon guidance GO:0008045 16 9 1,000 2,018E-03 0,01926625 ! alpha-beta T cell differentiation GO:0046632 21 9 1,000 2,018E-03 0,0191901 ! regulation of mitochondrial membrane potential GO:0051881 17 9 1,000 2,018E-03 0,01911454 ! postreplication repair GO:0006301 22 9 1,000 2,018E-03 0,01903959 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 20 9 1,000 2,018E-03 0,01896521 GO:0002820|negative regulation of adaptive immune response, ! DNA damage checkpoint GO:0000077 71 33 2,000 2,025E-03 0,01896092 ! negative regulation of protein transport GO:0051224 69 33 2,000 2,025E-03 0,01888743 ! reproductive structure development GO:0048608 113 71 3,000 2,158E-03 0,02004367 ! regulation of striated muscle tissue development GO:0016202 69 34 2,000 2,209E-03 0,02044094 ! regulation of caspase activity GO:0043281 122 72 3,000 2,271E-03 0,02093563 ! regulation of muscle development GO:0048634 70 35 2,000 2,402E-03 0,02206258 ! calcium-mediated signaling GO:0019722 62 35 2,000 2,402E-03 0,02197869 ! regulation of microtubule-based process GO:0032886 78 35 2,000 2,402E-03 0,02189544 ! neural tube formation GO:0001841 67 35 2,000 2,402E-03 0,02181281 ! negative regulation of DNA metabolic process GO:0051053 61 35 2,000 2,402E-03 0,02173081 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 2,51E-03 0,02261561 ! syncytium formation by plasma membrane fusion GO:0000768 16 10 1,000 2,51E-03 0,02253122 GO:0007520|myoblast fusion, ! Wnt receptor signaling pathway through beta-catenin GO:0060070 23 10 1,000 2,51E-03 0,02244746 ! positive regulation of heart contraction GO:0045823 16 10 1,000 2,51E-03 0,02236432 ! lung alveolus development GO:0048286 26 10 1,000 2,51E-03 0,0222818 ! negative regulation of striated muscle development GO:0045843 19 10 1,000 2,51E-03 0,02219988 ! B cell proliferation GO:0042100 18 10 1,000 2,51E-03 0,02211856 ! positive regulation of muscle contraction GO:0045933 14 10 1,000 2,51E-03 0,02203784 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 26 10 1,000 2,51E-03 0,0219577 ! regulation of bone resorption GO:0045124 25 10 1,000 2,51E-03 0,02187814 ! alpha-beta T cell activation GO:0046631 23 10 1,000 2,51E-03 0,02179916 ! response to dsRNA GO:0043331 20 10 1,000 2,51E-03 0,02172075 ! regulation of B cell differentiation GO:0045577 19 10 1,000 2,51E-03 0,02164289 ! oocyte development GO:0048599 17 10 1,000 2,51E-03 0,0215656 ! blastocyst formation GO:0001825 17 10 1,000 2,51E-03 0,02148885 ! response to nicotine GO:0035094 20 10 1,000 2,51E-03 0,02141265 ! establishment of cell polarity GO:0030010 16 10 1,000 2,51E-03 0,02133699 ! negative regulation of immune effector process GO:0002698 20 10 1,000 2,51E-03 0,02126186 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 2,51E-03 0,02118725 ! localization within membrane GO:0051668 20 10 1,000 2,51E-03 0,02111317 ! regulation of transcription factor activity GO:0051090 126 74 3,000 2,51E-03 0,02104294 GO:0090046|regulation of transcription regulator activity, ! regulation of endopeptidase activity GO:0052548 125 74 3,000 2,51E-03 0,02096987 ! cell junction organization GO:0034330 86 36 2,000 2,606E-03 0,02169774 ! maintenance of protein location in cell GO:0032507 86 36 2,000 2,606E-03 0,02162292 ! DNA integrity checkpoint GO:0031570 75 36 2,000 2,606E-03 0,02154861 ! negative regulation of cell activation GO:0050866 65 36 2,000 2,606E-03 0,02147482 ! lymphocyte differentiation GO:0030098 167 75 3,000 2,636E-03 0,0216447 ! regulation of catabolic process GO:0009894 161 76 3,000 2,766E-03 0,02263507 ! positive regulation of DNA metabolic process GO:0051054 72 38 2,000 3,045E-03 0,02483498 ! mitotic cell cycle checkpoint GO:0007093 76 38 2,000 3,045E-03 0,02475108 ! embryonic epithelial tube formation GO:0001838 72 38 2,000 3,045E-03 0,02466775 ! positive regulation of leukocyte proliferation GO:0070665 62 38 2,000 3,045E-03 0,02458497 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! negative regulation of muscle development GO:0048635 20 11 1,000 3,052E-03 0,02455906 ! regulation of nitric-oxide synthase activity GO:0050999 26 11 1,000 3,052E-03 0,0244772 ! T cell proliferation GO:0042098 26 11 1,000 3,052E-03 0,02439588 ! blood vessel remodeling GO:0001974 29 11 1,000 3,052E-03 0,0243151 ! positive regulation of endothelial cell proliferation GO:0001938 22 11 1,000 3,052E-03 0,02423485 ! peptide or protein amino-terminal blocking GO:0018409 21 11 1,000 3,052E-03 0,02415513 ! syncytium formation GO:0006949 18 11 1,000 3,052E-03 0,02407593 ! regulation of intracellular pH GO:0051453 19 11 1,000 3,052E-03 0,02399725 ! negative regulation of ossification GO:0030279 26 11 1,000 3,052E-03 0,02391908 ! positive regulation of T cell mediated immunity GO:0002711 24 11 1,000 3,052E-03 0,02384143 ! vasoconstriction GO:0042310 18 11 1,000 3,052E-03 0,02376427 ! regulation of isotype switching GO:0045191 22 11 1,000 3,052E-03 0,02368761 ! oocyte differentiation GO:0009994 18 11 1,000 3,052E-03 0,02361144 ! thymus development GO:0048538 27 11 1,000 3,052E-03 0,02353577 ! T cell receptor signaling pathway GO:0050852 23 11 1,000 3,052E-03 0,02346057 ! regulation of peptidase activity GO:0052547 134 79 3,000 3,182E-03 0,02438294 ! positive regulation of phosphorylation GO:0042327 129 79 3,000 3,182E-03 0,02430554 ! positive regulation of phosphorus metabolic process GO:0010562 136 81 3,000 3,482E-03 0,02651324 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 171 81 3,000 3,482E-03 0,0264296 ! maintenance of protein location GO:0045185 91 40 2,000 3,527E-03 0,02668198 ! response to drug GO:0042493 143 82 3,000 3,639E-03 0,02744803 ! response to nutrient GO:0007584 125 82 3,000 3,639E-03 0,02736225 ! cartilage condensation GO:0001502 20 12 1,000 3,644E-03 0,02731327 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 3,644E-03 0,02722845 ! regulation of cell projection assembly GO:0060491 30 12 1,000 3,644E-03 0,02714415 ! positive regulation of transcription factor import into nucleus GO:0042993 23 12 1,000 3,644E-03 0,02706037 ! focal adhesion formation GO:0048041 35 12 1,000 3,644E-03 0,02697711 ! membrane protein proteolysis GO:0033619 25 12 1,000 3,644E-03 0,02689436 GO:0006509|membrane protein ectodomain proteolysis, ! fear response GO:0042596 26 12 1,000 3,644E-03 0,02681211 ! histone acetylation GO:0016573 26 12 1,000 3,644E-03 0,02673037 ! gland morphogenesis GO:0022612 29 12 1,000 3,644E-03 0,02664912 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,644E-03 0,02656836 ! T cell homeostasis GO:0043029 25 12 1,000 3,644E-03 0,0264881 ! spleen development GO:0048536 22 12 1,000 3,644E-03 0,02640831 ! digestive tract morphogenesis GO:0048546 26 12 1,000 3,644E-03 0,02632901 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of blood vessel endothelial cell migration GO:0043535 37 12 1,000 3,644E-03 0,02625018 ! response to oxygen levels GO:0070482 176 83 3,000 3,801E-03 0,02729866 ! cytoskeleton-dependent intracellular transport GO:0030705 97 42 2,000 4,052E-03 0,02901572 ! regulation of cell-cell adhesion GO:0022407 33 13 1,000 4,285E-03 0,03059253 ! negative regulation of transcription factor import into nucleus GO:0042992 29 13 1,000 4,285E-03 0,03050202 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 4,285E-03 0,03041205 ! cell-cell junction assembly GO:0007043 27 13 1,000 4,285E-03 0,0303226 ! response to X-ray GO:0010165 25 13 1,000 4,285E-03 0,03023368 ! negative regulation of mitotic cell cycle GO:0045930 33 13 1,000 4,285E-03 0,03014527 ! regulation of cellular pH GO:0030641 22 13 1,000 4,285E-03 0,03005739 ! regulation of monooxygenase activity GO:0032768 33 13 1,000 4,285E-03 0,02997001 ! regulation of mRNA stability GO:0043488 31 13 1,000 4,285E-03 0,02988314 ! tube morphogenesis GO:0035239 176 86 3,000 4,315E-03 0,03000695 ! neural tube development GO:0021915 77 43 2,000 4,332E-03 0,03003477 ! regulation of epithelial cell proliferation GO:0050678 111 43 2,000 4,332E-03 0,02994846 ! regulation of protein transport GO:0051223 154 87 3,000 4,497E-03 0,03099915 GO:0070201|regulation of establishment of protein localization, ! male sex differentiation GO:0046661 76 44 2,000 4,623E-03 0,03177812 ! B cell differentiation GO:0030183 107 44 2,000 4,623E-03 0,03168758 ! maintenance of location in cell GO:0051651 97 44 2,000 4,623E-03 0,03159756 ! gland development GO:0048732 206 88 3,000 4,683E-03 0,03191836 ! rRNA transcription GO:0009303 25 14 1,000 4,974E-03 0,03380696 ! N-terminal protein amino acid modification GO:0031365 27 14 1,000 4,974E-03 0,03371173 ! regulation of S phase GO:0033261 23 14 1,000 4,974E-03 0,03361703 ! myotube differentiation GO:0014902 25 14 1,000 4,974E-03 0,03352287 ! positive regulation of GTPase activity GO:0043547 36 14 1,000 4,974E-03 0,03342923 ! hair follicle morphogenesis GO:0031069 26 14 1,000 4,974E-03 0,03333611 ! regulation of heart rate GO:0002027 24 14 1,000 4,974E-03 0,03324351 ! branching involved in ureteric bud morphogenesis GO:0001658 28 14 1,000 4,974E-03 0,03315142 GO:0060675|ureteric bud morphogenesis, ! negative regulation of protein import into nucleus GO:0042308 30 14 1,000 4,974E-03 0,03305985 ! cAMP biosynthetic process GO:0006171 23 14 1,000 4,974E-03 0,03296877 ! regulation of RNA stability GO:0043487 32 14 1,000 4,974E-03 0,0328782 ! sex differentiation GO:0007548 145 90 3,000 5,071E-03 0,03342819 ! positive regulation of protein transport GO:0051222 72 46 2,000 5,24E-03 0,03444432 ! positive regulation of defense response GO:0031349 76 47 2,000 5,566E-03 0,03648835 ! vascular process in circulatory system GO:0003018 80 47 2,000 5,566E-03 0,03638919 ! regulation of transmembrane transporter activity GO:0022898 27 15 1,000 5,711E-03 0,03723485 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 28 15 1,000 5,711E-03 0,03713421 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 5,711E-03 0,03703412 ! G1/S transition checkpoint GO:0031575 40 15 1,000 5,711E-03 0,03693457 ! intermediate filament cytoskeleton organization GO:0045104 31 15 1,000 5,711E-03 0,03683555 ! regulation of T cell mediated immunity GO:0002709 33 15 1,000 5,711E-03 0,03673705 ! C21-steroid hormone biosynthetic process GO:0006700 23 15 1,000 5,711E-03 0,03663909 ! lymphocyte homeostasis GO:0002260 30 15 1,000 5,711E-03 0,03654164 ! mitochondrial transport GO:0006839 82 48 2,000 5,904E-03 0,03767774 ! cellular component disassembly GO:0022411 86 48 2,000 5,904E-03 0,03757807 ! morphogenesis of embryonic epithelium GO:0016331 91 48 2,000 5,904E-03 0,03747892 ! regulation of inflammatory response GO:0050727 75 48 2,000 5,904E-03 0,03738029 ! regulation of T cell activation GO:0050863 158 94 3,000 5,911E-03 0,0373289 ! induction of apoptosis by extracellular signals GO:0008624 89 49 2,000 6,254E-03 0,0393894 ! peptide metabolic process GO:0006518 76 49 2,000 6,254E-03 0,03928655 ! regulation of protein ubiquitination GO:0031396 25 16 1,000 6,494E-03 0,04068709 ! embryonic forelimb morphogenesis GO:0035115 28 16 1,000 6,494E-03 0,04058141 ! negative regulation of nucleocytoplasmic transport GO:0046823 32 16 1,000 6,494E-03 0,04047628 ! negative regulation of microtubule depolymerization GO:0007026 46 16 1,000 6,494E-03 0,04037169 GO:0031114|regulation of microtubule depolymerization, ! intermediate filament-based process GO:0045103 32 16 1,000 6,494E-03 0,04026764 ! negative regulation of immune response GO:0050777 35 16 1,000 6,494E-03 0,04016412 ! axon cargo transport GO:0008088 43 16 1,000 6,494E-03 0,04006114 ! positive regulation of protein import into nucleus GO:0042307 30 16 1,000 6,494E-03 0,03995868 ! DNA replication initiation GO:0006270 27 16 1,000 6,494E-03 0,03985674 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 30 16 1,000 6,494E-03 0,03975533 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 6,494E-03 0,03965443 ! regulation of cell shape GO:0008360 125 51 2,000 6,99E-03 0,04258002 ! skeletal muscle tissue development GO:0007519 186 99 3,000 7,085E-03 0,04304799 GO:0060538|skeletal muscle organ development, ! positive regulation of cell killing GO:0031343 32 17 1,000 7,323E-03 0,04437889 ! metencephalon development GO:0022037 30 17 1,000 7,323E-03 0,04426738 ! negative regulation of cell cycle process GO:0010948 32 17 1,000 7,323E-03 0,04415644 ! signal complex assembly GO:0007172 41 17 1,000 7,323E-03 0,04404604 ! regulation of viral genome replication GO:0045069 28 17 1,000 7,323E-03 0,0439362 ! positive regulation of nitric oxide biosynthetic process GO:0045429 35 17 1,000 7,323E-03 0,04382691 ! DNA fragmentation involved in apoptosis GO:0006309 25 17 1,000 7,323E-03 0,04371816 ! regulation of immunoglobulin mediated immune response GO:0002889 32 17 1,000 7,323E-03 0,04360995 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of blood coagulation GO:0030195 24 17 1,000 7,323E-03 0,04350227 ! antigen receptor-mediated signaling pathway GO:0050851 33 17 1,000 7,323E-03 0,04339512 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 48 17 1,000 7,323E-03 0,0432885 ! regulation of neuron apoptosis GO:0043523 100 53 2,000 7,776E-03 0,0458584 ! phosphoinositide phosphorylation GO:0046854 33 18 1,000 8,197E-03 0,04821907 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 1,000 8,197E-03 0,04810146 GO:0050886|endocrine process, ! epidermis morphogenesis GO:0048730 40 18 1,000 8,197E-03 0,04798443 ! cell-substrate junction assembly GO:0007044 54 18 1,000 8,197E-03 0,04786796 ! regulation of immunoglobulin production GO:0002637 43 18 1,000 8,197E-03 0,04775206 ! skeletal muscle fiber development GO:0048741 111 56 2,000 9,05E-03 0,05259266 ! lipid phosphorylation GO:0046834 35 19 1,000 9,115E-03 0,0528473 ! forelimb morphogenesis GO:0035136 32 19 1,000 9,115E-03 0,05272027 ! bile acid metabolic process GO:0008206 29 19 1,000 9,115E-03 0,05259384 ! pigmentation during development GO:0048066 41 19 1,000 9,115E-03 0,05246802 ! neuromuscular junction development GO:0007528 34 19 1,000 9,115E-03 0,05234279 ! regulation of endothelial cell migration GO:0010594 44 19 1,000 9,115E-03 0,05221817 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 27 19 1,000 9,115E-03 0,05209413 ! cellular pigmentation GO:0033059 36 19 1,000 9,115E-03 0,05197069 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 32 19 1,000 9,115E-03 0,05184783 ! cell-cell junction organization GO:0045216 35 19 1,000 9,115E-03 0,05172554 ! regulation of bone remodeling GO:0046850 137 57 2,000 9,499E-03 0,05377784 ! muscle fiber development GO:0048747 112 57 2,000 9,499E-03 0,0536516 ! maintenance of location GO:0051235 118 57 2,000 9,499E-03 0,05352595 ! regulation of tissue remodeling GO:0034103 140 58 2,000 9,962E-03 0,0560016 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 31 20 1,000 0,01007763 0,05651927 ! protein amino acid acetylation GO:0006473 39 20 1,000 0,01007763 0,05638783 ! cAMP metabolic process GO:0046058 36 20 1,000 0,01007763 0,056257 ! C21-steroid hormone metabolic process GO:0008207 33 20 1,000 0,01007763 0,05612678 ! response to alkaloid GO:0043279 38 20 1,000 0,01007763 0,05599716 ! cellular response to starvation GO:0009267 33 20 1,000 0,01007763 0,05586813 ! regulation of nitric oxide biosynthetic process GO:0045428 40 20 1,000 0,01007763 0,0557397 ! negative regulation of angiogenesis GO:0016525 45 20 1,000 0,01007763 0,05561186 ! regulation of leukocyte mediated cytotoxicity GO:0001910 40 20 1,000 0,01007763 0,0554846 ! actin filament-based movement GO:0030048 43 20 1,000 0,01007763 0,05535792 ! negative regulation of coagulation GO:0050819 29 20 1,000 0,01007763 0,05523182 ! cellular monovalent inorganic cation homeostasis GO:0030004 36 20 1,000 0,01007763 0,05510629 ! cytokine-mediated signaling pathway GO:0019221 97 59 2,000 0,01043759 0,0569452 ! DNA damage response, signal transduction GO:0042770 128 60 2,000 0,0109261 0,05947553 ! regulation of cell killing GO:0031341 42 21 1,000 0,01108283 0,06019254 ! hindlimb morphogenesis GO:0035137 43 21 1,000 0,01108283 0,06005697 ! axis specification GO:0009798 38 21 1,000 0,01108283 0,05992201 ! ovarian follicle development GO:0001541 35 21 1,000 0,01108283 0,05978766 ! smooth muscle contraction GO:0006939 46 21 1,000 0,01108283 0,0596539 ! positive regulation of alpha-beta T cell activation GO:0046635 33 21 1,000 0,01108283 0,05952075 ! oogenesis GO:0048477 36 21 1,000 0,01108283 0,05938818 ! negative regulation of Wnt receptor signaling pathway GO:0030178 39 21 1,000 0,01108283 0,05925621 ! negative regulation of intracellular transport GO:0032387 41 21 1,000 0,01108283 0,05912482 ! response to cytokine stimulus GO:0034097 63 21 1,000 0,01108283 0,05899402 ! gut development GO:0048565 39 21 1,000 0,01108283 0,05886379 ! mesoderm development GO:0007498 119 61 2,000 0,01142763 0,06056142 ! response to peptide hormone stimulus GO:0043434 122 61 2,000 0,01142763 0,06042832 ! gonad development GO:0008406 98 62 2,000 0,01194226 0,06301111 ! microtubule-based transport GO:0010970 54 22 1,000 0,0121303 0,06386326 ! regeneration GO:0031099 41 22 1,000 0,0121303 0,06372382 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 59 22 1,000 0,0121303 0,06358499 ! vesicle docking during exocytosis GO:0006904 41 22 1,000 0,0121303 0,06344676 ! apoptotic nuclear changes GO:0030262 32 22 1,000 0,0121303 0,06330913 ! ureteric bud development GO:0001657 43 22 1,000 0,0121303 0,0631721 ! renal system process GO:0003014 41 22 1,000 0,0121303 0,06303566 ! positive regulation of adaptive immune response GO:0002821 39 22 1,000 0,0121303 0,0628998 ! response to glucocorticoid stimulus GO:0051384 38 22 1,000 0,0121303 0,06276454 ! activation of JUN kinase activity GO:0007257 42 22 1,000 0,0121303 0,06262985 ! myeloid leukocyte differentiation GO:0002573 40 23 1,000 0,01321934 0,06810649 ! regulation of DNA recombination GO:0000018 48 23 1,000 0,01321934 0,06796096 ! response to ethanol GO:0045471 46 23 1,000 0,01321934 0,06781606 ! immune response-activating cell surface receptor signaling pathway GO:0002429 40 23 1,000 0,01321934 0,06767177 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! sex determination GO:0007530 47 23 1,000 0,01321934 0,06752809 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 39 23 1,000 0,01321934 0,06738502 ! platelet activation GO:0030168 37 23 1,000 0,01321934 0,06724256 ! positive regulation of DNA replication GO:0045740 43 23 1,000 0,01321934 0,0671007 ! positive regulation of cell adhesion GO:0045785 56 23 1,000 0,01321934 0,06695943 ! leukocyte adhesion GO:0007159 50 23 1,000 0,01321934 0,06681876 ! activation of pro-apoptotic gene products GO:0008633 47 23 1,000 0,01321934 0,06667868 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 47 23 1,000 0,01321934 0,06653919 ! regulation of viral reproduction GO:0050792 38 23 1,000 0,01321934 0,06640027 ! myeloid cell differentiation GO:0030099 111 65 2,000 0,01356514 0,06799526 ! actin filament organization GO:0007015 148 66 2,000 0,01413259 0,07069235 ! protein import into nucleus, translocation GO:0000060 46 24 1,000 0,01434925 0,07162718 ! positive regulation of fibroblast proliferation GO:0048146 43 24 1,000 0,01434925 0,07147888 ! DNA catabolic process, endonucleolytic GO:0000737 35 24 1,000 0,01434925 0,0713312 ! regulation of transmembrane transport GO:0034762 38 24 1,000 0,01434925 0,07118412 ! vesicle docking GO:0048278 47 24 1,000 0,01434925 0,07103766 ! multicellular organismal response to stress GO:0033555 49 24 1,000 0,01434925 0,07089179 ! response to corticosteroid stimulus GO:0031960 41 24 1,000 0,01434925 0,07074652 ! regulation of alpha-beta T cell activation GO:0046634 42 24 1,000 0,01434925 0,07060184 ! positive regulation of leukocyte mediated immunity GO:0002705 43 24 1,000 0,01434925 0,07045776 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 46 24 1,000 0,01434925 0,07031426 ! leukocyte homeostasis GO:0001776 44 24 1,000 0,01434925 0,07017134 ! protein tetramerization GO:0051262 52 24 1,000 0,01434925 0,07002901 ! activation of MAPK activity GO:0000187 115 67 2,000 0,01471336 0,07166061 ! lung development GO:0030324 144 67 2,000 0,01471336 0,07151584 ! myelination GO:0042552 45 25 1,000 0,01551936 0,0752814 ! vasculogenesis GO:0001570 46 25 1,000 0,01551936 0,07512993 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 50 25 1,000 0,01551936 0,07497907 ! regulation of smooth muscle contraction GO:0006940 43 25 1,000 0,01551936 0,07482881 ! receptor metabolic process GO:0043112 46 25 1,000 0,01551936 0,07467915 ! response to starvation GO:0042594 42 25 1,000 0,01551936 0,07453009 ! negative regulation of cell development GO:0010721 73 25 1,000 0,01551936 0,07438162 GO:0050768|negative regulation of neurogenesis, ! fibroblast growth factor receptor signaling pathway GO:0008543 44 25 1,000 0,01551936 0,07423375 ! somitogenesis GO:0001756 43 25 1,000 0,01551936 0,07408646 ! immunoglobulin production GO:0002377 55 25 1,000 0,01551936 0,07393975 GO:0002440|production of molecular mediator of immune response, ! regulation of blood coagulation GO:0030193 40 25 1,000 0,01551936 0,07379363 ! cellular response to nutrient levels GO:0031669 41 25 1,000 0,01551936 0,07364808 ! respiratory tube development GO:0030323 150 70 2,000 0,01653586 0,07831749 ! molting cycle process GO:0022404 50 26 1,000 0,01672898 0,07907649 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! insulin receptor signaling pathway GO:0008286 64 26 1,000 0,01672898 0,07892144 ! regulation of endothelial cell proliferation GO:0001936 57 26 1,000 0,01672898 0,07876699 ! peptidyl-tyrosine phosphorylation GO:0018108 48 26 1,000 0,01672898 0,07861315 ! positive regulation of MAPKKK cascade GO:0043410 47 26 1,000 0,01672898 0,07845991 ! blastocyst development GO:0001824 49 26 1,000 0,01672898 0,07830726 ! positive regulation of JUN kinase activity GO:0043507 51 26 1,000 0,01672898 0,07815521 ! B cell activation GO:0042113 160 71 2,000 0,0171702 0,08006103 ! regulation of MAPKKK cascade GO:0043408 142 71 2,000 0,0171702 0,07990617 ! positive regulation of protein amino acid phosphorylation GO:0001934 108 72 2,000 0,01781798 0,08276075 ! respiratory system development GO:0060541 153 72 2,000 0,01781798 0,08260129 ! positive regulation of smooth muscle cell proliferation GO:0048661 43 27 1,000 0,01797746 0,08318033 ! positive regulation of cell projection organization GO:0031346 58 27 1,000 0,01797746 0,08302068 ! protein amino acid acylation GO:0043543 55 27 1,000 0,01797746 0,08286163 ! male gonad development GO:0008584 44 27 1,000 0,01797746 0,0827032 ! response to toxin GO:0009636 47 27 1,000 0,01797746 0,08254537 ! base-excision repair GO:0006284 41 27 1,000 0,01797746 0,08238814 ! cyclic nucleotide biosynthetic process GO:0009190 41 27 1,000 0,01797746 0,08223151 ! regulation of chromosome organization GO:0033044 42 27 1,000 0,01797746 0,08207547 ! glutathione metabolic process GO:0006749 39 27 1,000 0,01797746 0,08192003 ! exocytosis GO:0006887 133 74 2,000 0,019154 0,08711629 ! dendrite development GO:0016358 59 28 1,000 0,01926413 0,0874519 ! regulation of systemic arterial blood pressure GO:0003073 54 28 1,000 0,01926413 0,08728721 ! positive regulation of T cell differentiation GO:0045582 42 28 1,000 0,01926413 0,08712314 ! peptidyl-tyrosine modification GO:0018212 50 28 1,000 0,01926413 0,08695968 ! regulation of JUN kinase activity GO:0043506 58 28 1,000 0,01926413 0,08679683 ! elevation of cytosolic calcium ion concentration GO:0007204 133 75 2,000 0,01984225 0,08923451 ! phosphoinositide-mediated signaling GO:0048015 131 75 2,000 0,01984225 0,08906803 ! cytosolic calcium ion homeostasis GO:0051480 135 76 2,000 0,02054402 0,0920464 ! development of primary sexual characteristics GO:0045137 124 76 2,000 0,02054402 0,09187531 ! regulation of pH GO:0006885 43 29 1,000 0,02058835 0,09190273 ! immune response-activating signal transduction GO:0002757 47 29 1,000 0,02058835 0,09173254 GO:0002764|immune response-regulating signal transduction, ! regulation of production of molecular mediator of immune response GO:0002700 61 29 1,000 0,02058835 0,09156298 ! response to organic cyclic substance GO:0014070 55 29 1,000 0,02058835 0,09139405 ! negative regulation of neuron apoptosis GO:0043524 56 29 1,000 0,02058835 0,09122573 ! tissue homeostasis GO:0001894 48 29 1,000 0,02058835 0,09105804 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 46 29 1,000 0,02058835 0,09089096 ! positive regulation of lymphocyte activation GO:0051251 127 77 2,000 0,02125931 0,09368114 ! membrane docking GO:0022406 61 30 1,000 0,02194947 0,09654556 ! positive regulation of multicellular organism growth GO:0040018 51 30 1,000 0,02194947 0,09636938 ! ensheathment of neurons GO:0007272 57 30 1,000 0,02194947 0,09619385 GO:0008366|axon ensheathment, ! response to heat GO:0009408 50 30 1,000 0,02194947 0,09601895 ! negative regulation of organelle organization GO:0010639 161 78 2,000 0,02198813 0,09601349 ! ovulation cycle process GO:0022602 49 31 1,000 0,02334685 0,10176182 ! positive regulation of T cell proliferation GO:0042102 52 31 1,000 0,02334685 0,1015778 ! peptide transport GO:0015833 55 31 1,000 0,02334685 0,10139444 ! myeloid leukocyte activation GO:0002274 49 31 1,000 0,02334685 0,10121175 ! positive regulation of immune effector process GO:0002699 67 31 1,000 0,02334685 0,10102972 ! cellular lipid catabolic process GO:0044242 134 80 2,000 0,02348633 0,10145085 ! protein import into nucleus GO:0006606 158 80 2,000 0,02348633 0,10126903 ! nuclear import GO:0051170 161 81 2,000 0,02425572 0,10439941 ! response to hydrogen peroxide GO:0042542 50 32 1,000 0,02477987 0,10646494 ! spindle organization GO:0007051 46 32 1,000 0,02477987 0,10627516 ! metanephros development GO:0001656 74 32 1,000 0,02477987 0,10608606 ! ovulation cycle GO:0042698 51 32 1,000 0,02477987 0,10589763 ! peripheral nervous system development GO:0007422 64 32 1,000 0,02477987 0,10570987 ! hindbrain development GO:0030902 61 32 1,000 0,02477987 0,10552277 ! positive regulation of lymphocyte differentiation GO:0045621 48 32 1,000 0,02477987 0,10533633 ! post-embryonic development GO:0009791 69 33 1,000 0,0262479 0,11137999 ! positive regulation of gene-specific transcription GO:0043193 65 33 1,000 0,0262479 0,1111839 ! positive regulation of cell activation GO:0050867 145 85 2,000 0,02746835 0,11614911 GO:0002696|positive regulation of leukocyte activation, ! protein localization in nucleus GO:0034504 176 87 2,000 0,02915552 0,12306697 ! regulation of smooth muscle cell proliferation GO:0048660 59 35 1,000 0,02928657 0,12340367 ! embryonic skeletal system morphogenesis GO:0048704 59 35 1,000 0,02928657 0,12318793 ! female gonad development GO:0008585 58 35 1,000 0,02928657 0,12297294 ! negative regulation of hydrolase activity GO:0051346 62 35 1,000 0,02928657 0,1227587 ! positive regulation of protein modification process GO:0031401 136 88 2,000 0,03001925 0,125611 ! negative regulation of adenylate cyclase activity GO:0007194 58 36 1,000 0,030856 0,1288881 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of cell development GO:0010720 80 36 1,000 0,030856 0,12866472 ! regulation of Wnt receptor signaling pathway GO:0030111 71 36 1,000 0,030856 0,12844212 ! hormone biosynthetic process GO:0042446 57 36 1,000 0,030856 0,12822029 ! androgen receptor signaling pathway GO:0030521 74 36 1,000 0,030856 0,12799922 ! regulation of cell morphogenesis GO:0022604 215 89 2,000 0,0308964 0,12794618 ! ossification GO:0001503 188 90 2,000 0,03178692 0,13140779 ! meiosis I GO:0007127 65 37 1,000 0,03245804 0,13395205 ! establishment or maintenance of cell polarity GO:0007163 83 37 1,000 0,03245804 0,13372268 ! tissue remodeling GO:0048771 76 37 1,000 0,03245804 0,13349409 ! monovalent inorganic cation homeostasis GO:0055067 58 37 1,000 0,03245804 0,13326629 ! cyclic nucleotide metabolic process GO:0009187 63 37 1,000 0,03245804 0,13303926 ! glycogen metabolic process GO:0005977 61 37 1,000 0,03245804 0,132813 ! pigment metabolic process GO:0042440 80 37 1,000 0,03245804 0,13258751 ! cellular response to insulin stimulus GO:0032869 82 37 1,000 0,03245804 0,13236279 ! bone development GO:0060348 189 91 2,000 0,0326908 0,1330864 ! regulation of defense response GO:0031347 149 92 2,000 0,033608 0,13658928 ! development of primary female sexual characteristics GO:0046545 67 38 1,000 0,0340921 0,13832308 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 67 38 1,000 0,0340921 0,13809021 ! glucan metabolic process GO:0044042 62 38 1,000 0,0340921 0,13785813 GO:0006073|cellular glucan metabolic process, ! regulation of membrane potential GO:0042391 164 93 2,000 0,0345385 0,13942891 ! female pregnancy GO:0007565 164 94 2,000 0,03548226 0,14299885 ! mammary gland development GO:0030879 86 39 1,000 0,0357576 0,14386752 ! development of primary male sexual characteristics GO:0046546 66 39 1,000 0,0357576 0,14362734 ! segmentation GO:0035282 67 39 1,000 0,0357576 0,14338796 ! regulation of lymphocyte mediated immunity GO:0002706 74 39 1,000 0,0357576 0,14314938 ! regulation of action potential in neuron GO:0019228 73 39 1,000 0,0357576 0,14291159 ! Rho protein signal transduction GO:0007266 74 39 1,000 0,0357576 0,14267459 ! mesenchymal cell development GO:0014031 87 40 1,000 0,03745397 0,14919577 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! cytokinesis GO:0000910 72 40 1,000 0,03745397 0,14894916 ! negative regulation of nucleotide biosynthetic process GO:0030809 9 5 0,000 0,03760809 0,14931529 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03760809 0,1490693 ! positive regulation of helicase activity GO:0051096 11 5 0,000 0,03760809 0,14882412 ! neuron fate determination GO:0048664 7 5 0,000 0,03760809 0,14857975 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03760809 0,14833617 ! regulation of cGMP biosynthetic process GO:0030826 9 5 0,000 0,03760809 0,1480934 ! hemoglobin biosynthetic process GO:0042541 7 5 0,000 0,03760809 0,14785142 ! polyol transport GO:0015791 12 5 0,000 0,03760809 0,14761022 ! post-embryonic morphogenesis GO:0009886 8 5 0,000 0,03760809 0,14736981 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03760809 0,14713019 ! response to superoxide GO:0000303 10 5 0,000 0,03760809 0,14689134 ! positive regulation of lipid biosynthetic process GO:0046889 9 5 0,000 0,03760809 0,14665327 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 7 5 0,000 0,03760809 0,14641596 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03760809 0,14617943 ! female meiosis GO:0007143 7 5 0,000 0,03760809 0,14594366 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03760809 0,14570864 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03760809 0,14547438 ! cobalt ion transport GO:0006824 11 5 0,000 0,03760809 0,14524088 ! cellular sodium ion homeostasis GO:0006883 10 5 0,000 0,03760809 0,14500812 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 15 5 0,000 0,03760809 0,14477611 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 10 5 0,000 0,03760809 0,14454483 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03760809 0,1443143 ! regulation of cardiac muscle cell proliferation GO:0060043 8 5 0,000 0,03760809 0,1440845 ! embryonic camera-type eye development GO:0031076 10 5 0,000 0,03760809 0,14385543 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03760809 0,14362709 GO:0006451|translational readthrough, ! positive regulation of cell-cell adhesion GO:0022409 14 5 0,000 0,03760809 0,14339947 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03760809 0,14317257 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03760809 0,14294639 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03760809 0,14272092 ! negative chemotaxis GO:0050919 14 5 0,000 0,03760809 0,14249617 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03760809 0,14227212 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03760809 0,14204877 ! sensory perception of bitter taste GO:0050913 7 5 0,000 0,03760809 0,14182612 ! behavioral response to pain GO:0048266 9 5 0,000 0,03760809 0,14160417 ! clathrin coat assembly GO:0048268 14 5 0,000 0,03760809 0,14138292 ! Notch receptor processing GO:0007220 8 5 0,000 0,03760809 0,14116235 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03760809 0,14094247 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03760809 0,14072328 ! micturition GO:0060073 9 5 0,000 0,03760809 0,14050476 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03760809 0,14028692 ! copulation GO:0007620 9 5 0,000 0,03760809 0,14006976 ! glial cell fate commitment GO:0021781 13 5 0,000 0,03760809 0,13985327 ! protein maturation by protein folding GO:0022417 13 5 0,000 0,03760809 0,13963745 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03760809 0,13942229 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03760809 0,13920779 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03760809 0,13899396 ! apoptotic cell clearance GO:0043277 20 5 0,000 0,03760809 0,13878078 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03760809 0,13856825 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03760809 0,13835637 ! grooming behavior GO:0007625 6 5 0,000 0,03760809 0,13814514 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03760809 0,13793455 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 11 5 0,000 0,03760809 0,13772461 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03760809 0,1375153 ! response to protozoan GO:0001562 10 5 0,000 0,03760809 0,13730663 ! positive regulation of glycolysis GO:0045821 14 5 0,000 0,03760809 0,13709859 ! lymph vessel development GO:0001945 10 5 0,000 0,03760809 0,13689117 ! regulation of activin receptor signaling pathway GO:0032925 14 5 0,000 0,03760809 0,13668439 ! endochondral ossification GO:0001958 16 5 0,000 0,03760809 0,13647823 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03760809 0,13627269 ! parathyroid gland development GO:0060017 13 5 0,000 0,03760809 0,13606777 ! anagen GO:0042640 6 5 0,000 0,03760809 0,13586346 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,03760809 0,13565977 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03760809 0,13545669 ! hydrogen peroxide biosynthetic process GO:0050665 7 5 0,000 0,03760809 0,13525421 ! dorsal spinal cord development GO:0021516 7 5 0,000 0,03760809 0,13505234 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 12 5 0,000 0,03760809 0,13485107 ! sphingoid catabolic process GO:0046521 6 5 0,000 0,03760809 0,1346504 ! skeletal myofibril assembly GO:0014866 10 5 0,000 0,03760809 0,13445032 ! smooth muscle tissue development GO:0048745 28 5 0,000 0,03760809 0,13425084 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03760809 0,13405195 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 10 5 0,000 0,03760809 0,13385365 ! transepithelial chloride transport GO:0030321 9 5 0,000 0,03760809 0,13365593 GO:0070633|transepithelial transport, ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03760809 0,1334588 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! regulation of retroviral genome replication GO:0045091 7 5 0,000 0,03760809 0,13326225 ! negative regulation of survival gene product expression GO:0008634 8 5 0,000 0,03760809 0,13306627 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03760809 0,13287088 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03760809 0,13267605 ! histidine catabolic process GO:0006548 6 5 0,000 0,03760809 0,1324818 GO:0009077|histidine family amino acid catabolic process, ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03760809 0,13228811 ! valine metabolic process GO:0006573 10 5 0,000 0,03760809 0,13209499 ! L-serine biosynthetic process GO:0006564 6 5 0,000 0,03760809 0,13190243 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03760809 0,13171043 ! tryptophan metabolic process GO:0006568 9 5 0,000 0,03760809 0,13151899 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 17 5 0,000 0,03760809 0,13132811 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03760809 0,13113778 ! immunoglobulin V(D)J recombination GO:0033152 21 5 0,000 0,03760809 0,130948 ! polyol catabolic process GO:0046174 7 5 0,000 0,03760809 0,13075877 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03760809 0,13057008 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03760809 0,13038194 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03760809 0,13019434 ! muscle cell migration GO:0014812 8 5 0,000 0,03760809 0,13000728 ! mitochondrial fission GO:0000266 8 5 0,000 0,03760809 0,12982076 ! sister chromatid cohesion GO:0007062 12 5 0,000 0,03760809 0,12963477 ! mRNA transcription GO:0009299 9 5 0,000 0,03760809 0,12944931 ! peptidoglycan metabolic process GO:0000270 5 5 0,000 0,03760809 0,12926438 GO:0009253|peptidoglycan catabolic process, ! nerve growth factor processing GO:0032455 8 5 0,000 0,03760809 0,12907998 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03760809 0,12889611 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03760809 0,12871275 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03760809 0,12852992 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03760809 0,12834761 ! response to food GO:0032094 6 5 0,000 0,03760809 0,12816582 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,03760809 0,12798454 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03760809 0,12780377 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 11 5 0,000 0,03760809 0,12762351 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03760809 0,12744376 ! paraxial mesoderm development GO:0048339 14 5 0,000 0,03760809 0,12726451 ! forebrain neuron development GO:0021884 13 5 0,000 0,03760809 0,12708577 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03760809 0,12690753 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 9 5 0,000 0,03760809 0,12672978 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03760809 0,12655254 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03760809 0,12637579 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 9 5 0,000 0,03760809 0,12619953 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03760809 0,12602377 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 10 5 0,000 0,03760809 0,12584849 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 7 5 0,000 0,03760809 0,1256737 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03760809 0,1254994 ! positive regulation of fatty acid metabolic process GO:0045923 11 5 0,000 0,03760809 0,12532558 ! basic amino acid transport GO:0015802 11 5 0,000 0,03760809 0,12515224 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03760809 0,12497937 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03760809 0,12480699 ! depyrimidination GO:0045008 10 5 0,000 0,03760809 0,12463508 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03760809 0,12446364 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03760809 0,12429267 ! zinc ion homeostasis GO:0055069 8 5 0,000 0,03760809 0,12412218 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 7 5 0,000 0,03760809 0,12395215 ! nucleoside monophosphate catabolic process GO:0009125 11 5 0,000 0,03760809 0,12378258 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03760809 0,12361348 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03760809 0,12344484 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03760809 0,12327666 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 10 5 0,000 0,03760809 0,12310893 ! peptidyl-arginine modification GO:0018195 9 5 0,000 0,03760809 0,12294167 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03760809 0,12277485 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03760809 0,12260849 ! response to arsenic GO:0046685 10 5 0,000 0,03760809 0,12244258 ! mast cell degranulation GO:0043303 7 5 0,000 0,03760809 0,12227712 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 7 5 0,000 0,03760809 0,1221121 ! base-excision repair, DNA ligation GO:0006288 7 5 0,000 0,03760809 0,12194753 ! response to cadmium ion GO:0046686 7 5 0,000 0,03760809 0,1217834 ! bile acid biosynthetic process GO:0006699 6 5 0,000 0,03760809 0,12161971 ! sphingomyelin catabolic process GO:0006685 5 5 0,000 0,03760809 0,12145646 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03760809 0,12129365 ! decidualization GO:0046697 11 5 0,000 0,03760809 0,12113128 ! platelet activating factor biosynthetic process GO:0006663 6 5 0,000 0,03760809 0,12096934 ! CD4-positive, alpha beta T cell differentiation GO:0043367 8 5 0,000 0,03760809 0,12080783 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03760809 0,12064676 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03760809 0,12048611 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 7 5 0,000 0,03760809 0,12032589 ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03760809 0,12016609 ! neural tube patterning GO:0021532 7 5 0,000 0,03760809 0,12000672 ! embryonic cleavage GO:0040016 6 5 0,000 0,03760809 0,11984777 ! peroxisome fission GO:0016559 5 5 0,000 0,03760809 0,11968924 ! histone demethylation GO:0016577 10 5 0,000 0,03760809 0,11953113 ! reproductive behavior in a multicellular organism GO:0033057 14 5 0,000 0,03760809 0,11937344 ! mitotic recombination GO:0006312 9 5 0,000 0,03760809 0,11921616 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03760809 0,1190593 ! metaphase plate congression GO:0051310 7 5 0,000 0,03760809 0,11890285 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03760809 0,11874681 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03760809 0,11859117 ! enteric nervous system development GO:0048484 8 5 0,000 0,03760809 0,11843595 ! indolalkylamine biosynthetic process GO:0046219 7 5 0,000 0,03760809 0,11828113 GO:0042435|indole derivative biosynthetic process, GO:0030187|melatonin biosynthetic process, ! lymphocyte costimulation GO:0031294 6 5 0,000 0,03760809 0,11812672 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 11 5 0,000 0,03760809 0,11797271 ! muscle cell proliferation GO:0033002 11 5 0,000 0,03760809 0,1178191 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03760809 0,11766589 ! plasminogen activation GO:0031639 5 5 0,000 0,03760809 0,11751307 ! positive regulation of Wnt receptor signaling pathway GO:0030177 11 5 0,000 0,03760809 0,11736066 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03760809 0,11720864 ! positive regulation of blood coagulation GO:0030194 11 5 0,000 0,03760809 0,11705701 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03760809 0,11690577 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03760809 0,11675492 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03760809 0,11660447 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03760809 0,1164544 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03760809 0,11630471 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 13 5 0,000 0,03760809 0,11615541 ! response to redox state GO:0051775 5 5 0,000 0,03760809 0,1160065 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 6 5 0,000 0,03760809 0,11585796 ! regulation of hydrogen peroxide metabolic process GO:0010310 6 5 0,000 0,03760809 0,1157098 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03760809 0,11556203 ! regulation of telomerase activity GO:0051972 6 5 0,000 0,03760809 0,11541463 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03760809 0,1152676 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 11 5 0,000 0,03760809 0,11512095 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03760809 0,11497467 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 13 5 0,000 0,03760809 0,11482876 ! striatum development GO:0021756 9 5 0,000 0,03760809 0,11468323 ! activation of Ras GTPase activity GO:0032856 10 5 0,000 0,03760809 0,11453806 GO:0032862|activation of Rho GTPase activity, ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03760809 0,11439326 ! glial cell migration GO:0008347 11 5 0,000 0,03760809 0,11424882 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03760809 0,11410475 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03760809 0,11396104 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03760809 0,11381769 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03760809 0,11367471 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03760809 0,11353208 ! neuroprotection GO:0043526 6 5 0,000 0,03760809 0,11338981 ! neural plate development GO:0001840 8 5 0,000 0,03760809 0,11324789 ! regulation of sensory perception GO:0051931 7 5 0,000 0,03760809 0,11310633 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03760809 0,11296513 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 17 5 0,000 0,03760809 0,11282427 ! negative regulation of actin filament bundle formation GO:0032232 14 5 0,000 0,03760809 0,11268377 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03760809 0,11254361 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03760809 0,11240381 ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03760809 0,11226435 ! spindle assembly GO:0051225 6 5 0,000 0,03760809 0,11212524 ! metallo-sulfur cluster assembly GO:0031163 5 5 0,000 0,03760809 0,11198647 GO:0016226|iron-sulfur cluster assembly, ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,03760809 0,11184804 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03760809 0,11170996 ! drug metabolic process GO:0017144 6 5 0,000 0,03760809 0,11157221 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03760809 0,11143481 ! organ regeneration GO:0031100 7 5 0,000 0,03760809 0,11129774 ! carnitine metabolic process GO:0009437 7 5 0,000 0,03760809 0,11116102 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03760809 0,11102462 ! protein ubiquitination GO:0016567 217 97 2,000 0,03839273 0,11320211 ! calcium-dependent cell-cell adhesion GO:0016339 52 41 1,000 0,03918065 0,11538388 ! female gamete generation GO:0007292 61 41 1,000 0,03918065 0,11524283 ! dorsal/ventral pattern formation GO:0009953 68 41 1,000 0,03918065 0,11510212 ! response to virus GO:0009615 160 98 2,000 0,03938917 0,11557358 ! carboxylic acid catabolic process GO:0046395 156 98 2,000 0,03938917 0,11543281 GO:0016054|organic acid catabolic process, ! positive regulation of transcription factor activity GO:0051091 62 42 1,000 0,04093707 0,11982312 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 67 42 1,000 0,04093707 0,11967752 ! negative regulation of protein complex disassembly GO:0043242 101 42 1,000 0,04093707 0,11953228 ! regulation of tube size GO:0035150 71 42 1,000 0,04093707 0,1193874 GO:0050880|regulation of blood vessel size, ! regulation of leukocyte mediated immunity GO:0002703 79 42 1,000 0,04093707 0,11924286 ! neuron migration GO:0001764 79 42 1,000 0,04093707 0,11909867 ! epithelial cell differentiation GO:0030855 79 43 1,000 0,0427227 0,12414351 ! energy reserve metabolic process GO:0006112 74 43 1,000 0,0427227 0,12399375 ! double-strand break repair GO:0006302 81 44 1,000 0,04453699 0,1291036 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 77 44 1,000 0,04453699 0,12894824 ! developmental growth GO:0048589 82 44 1,000 0,04453699 0,12879325 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04495899 0,12985753 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04495899 0,12970182 ! negative regulation of S phase of mitotic cell cycle GO:0045749 11 6 0,000 0,04495899 0,12954649 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04495899 0,12939153 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04495899 0,12923694 ! oligosaccharide biosynthetic process GO:0009312 10 6 0,000 0,04495899 0,12908272 ! regulation of cGMP metabolic process GO:0030823 11 6 0,000 0,04495899 0,12892887 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04495899 0,12877538 ! sleep GO:0030431 13 6 0,000 0,04495899 0,12862226 ! response to oxygen radical GO:0000305 11 6 0,000 0,04495899 0,1284695 ! positive regulation of axon extension GO:0045773 11 6 0,000 0,04495899 0,1283171 ! myoblast cell fate commitment GO:0048625 16 6 0,000 0,04495899 0,12816507 ! negative regulation of small GTPase mediated signal transduction GO:0051058 17 6 0,000 0,04495899 0,1280134 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 11 6 0,000 0,04495899 0,12786208 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04495899 0,12771112 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,04495899 0,12756052 ! virion attachment to host cell surface receptor GO:0019062 15 6 0,000 0,04495899 0,12741027 ! forebrain regionalization GO:0021871 8 6 0,000 0,04495899 0,12726038 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,04495899 0,12711083 ! male meiosis GO:0007140 7 6 0,000 0,04495899 0,12696164 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04495899 0,1268128 ! response to zinc ion GO:0010043 9 6 0,000 0,04495899 0,12666431 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04495899 0,12651616 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 24 6 0,000 0,04495899 0,12636836 ! regulation of respiratory gaseous exchange GO:0043576 8 6 0,000 0,04495899 0,12622091 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04495899 0,1260738 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04495899 0,12592703 ! malate metabolic process GO:0006108 11 6 0,000 0,04495899 0,1257806 ! posttranscriptional gene silencing by RNA GO:0035194 19 6 0,000 0,04495899 0,12563452 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 9 6 0,000 0,04495899 0,12548877 ! protein refolding GO:0042026 15 6 0,000 0,04495899 0,12534336 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,04495899 0,12519829 ! opsonization GO:0008228 8 6 0,000 0,04495899 0,12505355 ! mating behavior GO:0007617 7 6 0,000 0,04495899 0,12490914 ! neuron remodeling GO:0016322 15 6 0,000 0,04495899 0,12476507 ! erythrocyte maturation GO:0043249 7 6 0,000 0,04495899 0,12462133 ! embryonic hemopoiesis GO:0035162 14 6 0,000 0,04495899 0,12447793 ! equilibrioception GO:0050957 14 6 0,000 0,04495899 0,12433485 ! protein amino acid dealkylation GO:0008214 12 6 0,000 0,04495899 0,1241921 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 9 6 0,000 0,04495899 0,12404968 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04495899 0,12390758 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 9 6 0,000 0,04495899 0,12376581 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04495899 0,12362436 ! response to interferon-gamma GO:0034341 15 6 0,000 0,04495899 0,12348324 ! toxin metabolic process GO:0009404 11 6 0,000 0,04495899 0,12334244 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04495899 0,12320196 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04495899 0,1230618 ! spinal cord dorsal/ventral patterning GO:0021513 12 6 0,000 0,04495899 0,12292195 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 12 6 0,000 0,04495899 0,12278243 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 12 6 0,000 0,04495899 0,12264322 ! cGMP-mediated signaling GO:0019934 13 6 0,000 0,04495899 0,12250432 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,04495899 0,12236575 ! dermatan sulfate proteoglycan metabolic process GO:0050655 13 6 0,000 0,04495899 0,12222748 ! protein lipoylation GO:0009249 10 6 0,000 0,04495899 0,12208952 ! cysteine metabolic process GO:0006534 10 6 0,000 0,04495899 0,12195188 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,04495899 0,12181455 ! glutamate catabolic process GO:0006538 10 6 0,000 0,04495899 0,12167752 ! mitochondrial respiratory chain complex assembly GO:0033108 10 6 0,000 0,04495899 0,12154081 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04495899 0,1214044 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! adenohypophysis development GO:0021984 10 6 0,000 0,04495899 0,12126829 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 11 6 0,000 0,04495899 0,1211325 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04495899 0,120997 ! hyperosmotic response GO:0006972 9 6 0,000 0,04495899 0,12086181 ! chromatin-mediated maintenance of transcription GO:0048096 13 6 0,000 0,04495899 0,12072692 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 9 6 0,000 0,04495899 0,12059233 ! urea metabolic process GO:0019627 7 6 0,000 0,04495899 0,12045804 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04495899 0,12032405 ! neutrophil activation GO:0042119 8 6 0,000 0,04495899 0,12019035 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,04495899 0,12005696 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 9 6 0,000 0,04495899 0,11992386 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04495899 0,11979105 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04495899 0,11965854 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04495899 0,11952632 ! neuron apoptosis GO:0051402 9 6 0,000 0,04495899 0,11939439 ! nucleoside salvage GO:0043174 9 6 0,000 0,04495899 0,11926275 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 15 6 0,000 0,04495899 0,11913141 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,04495899 0,11900035 ! T cell mediated immunity GO:0002456 16 6 0,000 0,04495899 0,11886958 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04495899 0,1187391 GO:0010543|regulation of platelet activation, ! male sex determination GO:0030238 15 6 0,000 0,04495899 0,1186089 ! carnitine transport GO:0015879 10 6 0,000 0,04495899 0,11847899 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 14 6 0,000 0,04495899 0,11834936 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04495899 0,11822002 ! positive regulation of exocytosis GO:0045921 8 6 0,000 0,04495899 0,11809096 ! protein import into mitochondrial inner membrane GO:0045039 8 6 0,000 0,04495899 0,11796218 ! 5S class rRNA transcription GO:0042791 11 6 0,000 0,04495899 0,11783368 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04495899 0,11770546 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 12 6 0,000 0,04495899 0,11757752 ! regulation of collagen metabolic process GO:0010712 9 6 0,000 0,04495899 0,11744986 ! sodium ion homeostasis GO:0055078 11 6 0,000 0,04495899 0,11732247 ! deoxyribonucleoside metabolic process GO:0009120 8 6 0,000 0,04495899 0,11719536 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,04495899 0,11706853 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 11 6 0,000 0,04495899 0,11694197 ! astrocyte development GO:0014002 15 6 0,000 0,04495899 0,11681568 ! protein targeting to lysosome GO:0006622 10 6 0,000 0,04495899 0,11668966 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04495899 0,11656392 ! interaction with symbiont GO:0051702 13 6 0,000 0,04495899 0,11643845 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04495899 0,11631325 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04495899 0,11618831 ! positive regulation of cytokine production during immune response GO:0002720 9 6 0,000 0,04495899 0,11606365 ! response to copper ion GO:0046688 10 6 0,000 0,04495899 0,11593925 ! response to exogenous dsRNA GO:0043330 10 6 0,000 0,04495899 0,11581512 ! enucleate erythrocyte differentiation GO:0043353 12 6 0,000 0,04495899 0,11569125 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04495899 0,11556765 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04495899 0,11544431 ! positive regulation of B cell differentiation GO:0045579 11 6 0,000 0,04495899 0,11532124 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04495899 0,11519842 ! nucleoside catabolic process GO:0009164 7 6 0,000 0,04495899 0,11507587 ! hair follicle maturation GO:0048820 7 6 0,000 0,04495899 0,11495358 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04495899 0,11483155 ! Schwann cell development GO:0014044 15 6 0,000 0,04495899 0,11470978 ! purine deoxyribonucleotide metabolic process GO:0009151 7 6 0,000 0,04495899 0,11458826 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04495899 0,114467 ! subpallium development GO:0021544 10 6 0,000 0,04495899 0,114346 ! negative regulation of multicellular organism growth GO:0040015 8 6 0,000 0,04495899 0,11422526 ! histone ubiquitination GO:0016574 8 6 0,000 0,04495899 0,11410477 ! regulation of myeloid leukocyte mediated immunity GO:0002886 8 6 0,000 0,04495899 0,11398453 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04495899 0,11386455 ! G2 phase GO:0051319 16 6 0,000 0,04495899 0,11374481 GO:0000085|G2 phase of mitotic cell cycle, ! tetracycline transport GO:0015904 8 6 0,000 0,04495899 0,11362533 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04495899 0,11350611 ! regulation of mast cell activation GO:0033003 12 6 0,000 0,04495899 0,11338713 ! membrane to membrane docking GO:0022614 14 6 0,000 0,04495899 0,1132684 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04495899 0,11314992 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 8 6 0,000 0,04495899 0,11303168 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04495899 0,11291369 ! receptor internalization GO:0031623 10 6 0,000 0,04495899 0,11279595 ! positive regulation of pseudopodium assembly GO:0031274 14 6 0,000 0,04495899 0,11267846 GO:0031272|regulation of pseudopodium assembly, ! neutrophil homeostasis GO:0001780 10 6 0,000 0,04495899 0,11256121 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04495899 0,1124442 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 13 6 0,000 0,04495899 0,11232743 ! protein deubiquitination GO:0016579 14 6 0,000 0,04495899 0,11221091 ! protein destabilization GO:0031648 9 6 0,000 0,04495899 0,11209463 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04495899 0,11197859 ! tetrahydrobiopterin biosynthetic process GO:0006729 8 6 0,000 0,04495899 0,11186279 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04495899 0,11174723 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 10 6 0,000 0,04495899 0,11163191 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 12 6 0,000 0,04495899 0,11151682 ! nonprotein amino acid metabolic process GO:0019794 12 6 0,000 0,04495899 0,11140198 ! negative regulation of axon extension GO:0030517 21 6 0,000 0,04495899 0,11128736 ! removal of superoxide radicals GO:0019430 11 6 0,000 0,04495899 0,11117299 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,04495899 0,11105885 ! determination of adult lifespan GO:0008340 15 6 0,000 0,04495899 0,11094494 ! ectodermal gut morphogenesis GO:0048567 12 6 0,000 0,04495899 0,11083127 GO:0007439|ectodermal gut development, ! positive regulation of fibrinolysis GO:0051919 8 6 0,000 0,04495899 0,11071783 ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04495899 0,11060462 ! catecholamine transport GO:0051937 9 6 0,000 0,04495899 0,11049164 ! negative regulation of NF-kappaB import into nucleus GO:0042347 14 6 0,000 0,04495899 0,1103789 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04495899 0,11026638 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04495899 0,11015409 ! maternal placenta development GO:0001893 12 6 0,000 0,04495899 0,11004203 ! regulation of T cell receptor signaling pathway GO:0050856 9 6 0,000 0,04495899 0,1099302 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04495899 0,1098186 ! protein amino acid prenylation GO:0018346 16 6 0,000 0,04495899 0,10970722 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04495899 0,10959607 ! positive regulation of microtubule polymerization GO:0031116 13 6 0,000 0,04495899 0,10948514 ! positive regulation of coagulation GO:0050820 12 6 0,000 0,04495899 0,10937444 ! branching morphogenesis of a tube GO:0048754 97 45 1,000 0,04637939 0,11271596 ! cell growth GO:0016049 84 45 1,000 0,04637939 0,11260222 ! regulation of gene-specific transcription GO:0032583 96 46 1,000 0,04824937 0,11702419 ! response to insulin stimulus GO:0032868 95 46 1,000 0,04824937 0,11690634 ! endosome transport GO:0016197 108 47 1,000 0,05014642 0,12138058 ! positive regulation of DNA binding GO:0043388 73 47 1,000 0,05014642 0,12125859 ! regulation of adaptive immune response GO:0002819 84 47 1,000 0,05014642 0,12113684 ! JNK cascade GO:0007254 91 47 1,000 0,05014642 0,12101534 ! regulation of JNK cascade GO:0046328 94 47 1,000 0,05014642 0,12089408 ! positive regulation of cell cycle GO:0045787 89 48 1,000 0,05207002 0,12540587 ! Notch signaling pathway GO:0007219 96 48 1,000 0,05207002 0,12528046 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 98 48 1,000 0,05207002 0,12515531 ! tRNA transcription GO:0009304 14 7 0,000 0,05225398 0,12547212 ! positive regulation of MHC class II biosynthetic process GO:0045348 11 7 0,000 0,05225398 0,12534702 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 12 7 0,000 0,05225398 0,12522218 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,05225398 0,12509758 ! cytokinesis during cell cycle GO:0033205 11 7 0,000 0,05225398 0,12497322 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 12 7 0,000 0,05225398 0,12484912 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,05225398 0,12472526 ! chaperone mediated protein folding requiring cofactor GO:0051085 11 7 0,000 0,05225398 0,12460165 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,05225398 0,12447828 ! nucleotide-sugar transport GO:0015780 12 7 0,000 0,05225398 0,12435516 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05225398 0,12423228 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,05225398 0,12410964 ! regulation of lipid catabolic process GO:0050994 15 7 0,000 0,05225398 0,12398724 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05225398 0,12386509 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid biosynthetic process GO:0046460 11 7 0,000 0,05225398 0,12374317 GO:0046463|acylglycerol biosynthetic process, ! platelet activating factor metabolic process GO:0046469 11 7 0,000 0,05225398 0,1236215 ! regulation of lipid kinase activity GO:0043550 13 7 0,000 0,05225398 0,12350006 ! N-acetylglucosamine catabolic process GO:0006046 9 7 0,000 0,05225398 0,12337887 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,05225398 0,12325791 ! SMAD protein complex assembly GO:0007183 12 7 0,000 0,05225398 0,12313718 ! glycolipid transport GO:0046836 10 7 0,000 0,05225398 0,1230167 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,05225398 0,12289645 GO:0051923|sulfation, ! neuron adhesion GO:0007158 12 7 0,000 0,05225398 0,12277643 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,05225398 0,12265665 ! actin-myosin filament sliding GO:0033275 11 7 0,000 0,05225398 0,1225371 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! establishment of tissue polarity GO:0007164 8 7 0,000 0,05225398 0,12241778 ! protein thiol-disulfide exchange GO:0006467 9 7 0,000 0,05225398 0,1222987 ! receptor guanylyl cyclase signaling pathway GO:0007168 8 7 0,000 0,05225398 0,12217985 ! nucleotide-excision repair, DNA incision GO:0033683 10 7 0,000 0,05225398 0,12206123 ! pericardium development GO:0060039 14 7 0,000 0,05225398 0,12194284 ! glucocorticoid receptor signaling pathway GO:0042921 13 7 0,000 0,05225398 0,12182467 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 16 7 0,000 0,05225398 0,12170674 ! oxaloacetate metabolic process GO:0006107 10 7 0,000 0,05225398 0,12158904 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05225398 0,12147156 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,05225398 0,12135431 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,05225398 0,12123728 ! lipoprotein transport GO:0042953 14 7 0,000 0,05225398 0,12112049 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05225398 0,12100391 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05225398 0,12088756 ! rhythmic behavior GO:0007622 15 7 0,000 0,05225398 0,12077144 ! regulation of dopamine metabolic process GO:0042053 11 7 0,000 0,05225398 0,12065553 GO:0042069|regulation of catecholamine metabolic process, ! estrogen metabolic process GO:0008210 17 7 0,000 0,05225398 0,12053985 ! sensory perception of temperature stimulus GO:0050951 11 7 0,000 0,05225398 0,12042439 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,05225398 0,12030915 ! regulation of odontogenesis GO:0042481 13 7 0,000 0,05225398 0,12019413 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,05225398 0,12007934 ! amyloid precursor protein catabolic process GO:0042987 11 7 0,000 0,05225398 0,11996476 ! mechanosensory behavior GO:0007638 14 7 0,000 0,05225398 0,11985039 ! DNA ligation during DNA repair GO:0051103 13 7 0,000 0,05225398 0,11973625 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05225398 0,11962233 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05225398 0,11950862 ! spinal cord patterning GO:0021511 13 7 0,000 0,05225398 0,11939512 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 20 7 0,000 0,05225398 0,11928184 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,05225398 0,11916878 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 12 7 0,000 0,05225398 0,11905593 ! adrenal gland development GO:0030325 17 7 0,000 0,05225398 0,1189433 ! induction of apoptosis by oxidative stress GO:0008631 8 7 0,000 0,05225398 0,11883087 ! regulation of defense response to virus by host GO:0050691 7 7 0,000 0,05225398 0,11871866 ! ovulation GO:0030728 9 7 0,000 0,05225398 0,11860666 ! deoxyribonucleotide biosynthetic process GO:0009263 10 7 0,000 0,05225398 0,11849488 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 9 7 0,000 0,05225398 0,1183833 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 19 7 0,000 0,05225398 0,11827193 ! microtubule nucleation GO:0007020 20 7 0,000 0,05225398 0,11816077 ! proline biosynthetic process GO:0006561 10 7 0,000 0,05225398 0,11804983 ! thyroid hormone generation GO:0006590 13 7 0,000 0,05225398 0,11793908 ! regulation of granule cell precursor proliferation GO:0021936 13 7 0,000 0,05225398 0,11782855 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 11 7 0,000 0,05225398 0,11771822 ! tetrahydrobiopterin metabolic process GO:0046146 10 7 0,000 0,05225398 0,1176081 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05225398 0,11749819 ! galactose metabolic process GO:0006012 13 7 0,000 0,05225398 0,11738848 ! vesicle fusion GO:0006906 17 7 0,000 0,05225398 0,11727898 ! response to dietary excess GO:0002021 8 7 0,000 0,05225398 0,11716968 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,05225398 0,11706058 ! intracellular pH reduction GO:0051452 11 7 0,000 0,05225398 0,11695169 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,05225398 0,116843 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 9 7 0,000 0,05225398 0,11673451 ! purine salvage GO:0043101 10 7 0,000 0,05225398 0,11662622 ! nucleoside transport GO:0015858 8 7 0,000 0,05225398 0,11651813 ! negative regulation of DNA recombination GO:0045910 15 7 0,000 0,05225398 0,11641024 ! parturition GO:0007567 14 7 0,000 0,05225398 0,11630256 ! positive regulation of mitotic cell cycle GO:0045931 12 7 0,000 0,05225398 0,11619507 ! rRNA modification GO:0000154 14 7 0,000 0,05225398 0,11608778 ! regulation of chromatin assembly or disassembly GO:0001672 13 7 0,000 0,05225398 0,11598069 ! spindle checkpoint GO:0031577 15 7 0,000 0,05225398 0,11587379 ! wound healing, spreading of epidermal cells GO:0035313 14 7 0,000 0,05225398 0,11576709 ! regulation of cholesterol biosynthetic process GO:0045540 12 7 0,000 0,05225398 0,11566059 ! macrophage differentiation GO:0030225 11 7 0,000 0,05225398 0,11555429 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05225398 0,11544818 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,05225398 0,11534226 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 13 7 0,000 0,05225398 0,11523654 ! hyaluronan metabolic process GO:0030212 8 7 0,000 0,05225398 0,11513101 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,05225398 0,11502568 ! eating behavior GO:0042755 7 7 0,000 0,05225398 0,11492053 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,05225398 0,11481558 ! positive regulation of systemic arterial blood pressure GO:0003084 10 7 0,000 0,05225398 0,11471082 ! negative regulation of interferon-gamma production GO:0032689 12 7 0,000 0,05225398 0,11460626 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,05225398 0,11450188 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,05225398 0,11439769 ! cranial nerve morphogenesis GO:0021602 11 7 0,000 0,05225398 0,11429369 ! phosphatidylinositol biosynthetic process GO:0006661 14 7 0,000 0,05225398 0,11418989 ! regulation of interleukin-1 beta production GO:0032651 10 7 0,000 0,05225398 0,11408626 ! phosphatidylserine metabolic process GO:0006658 8 7 0,000 0,05225398 0,11398283 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,05225398 0,11387959 ! positive regulation of tumor necrosis factor production GO:0032760 9 7 0,000 0,05225398 0,11377653 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,05225398 0,11367366 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,05225398 0,11357097 ! regulation of meiosis GO:0040020 12 7 0,000 0,05225398 0,11346847 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 13 7 0,000 0,05225398 0,11336615 ! regulation of lipid transport GO:0032368 14 7 0,000 0,05225398 0,11326402 ! oxygen homeostasis GO:0032364 12 7 0,000 0,05225398 0,11316207 ! transcription termination GO:0006353 13 7 0,000 0,05225398 0,11306031 ! regulation of respiratory burst GO:0060263 11 7 0,000 0,05225398 0,11295873 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,05225398 0,11285733 ! anaphase GO:0051322 17 7 0,000 0,05225398 0,11275611 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 16 7 0,000 0,05225398 0,11265508 ! axonal fasciculation GO:0007413 18 7 0,000 0,05225398 0,11255422 ! negative regulation of nuclear division GO:0051784 14 7 0,000 0,05225398 0,11245355 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 12 7 0,000 0,05225398 0,11235305 ! diuresis GO:0030146 12 7 0,000 0,05225398 0,11225274 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,05225398 0,1121526 ! thiamin metabolic process GO:0006772 7 7 0,000 0,05225398 0,11205264 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05225398 0,11195286 ! antibiotic transport GO:0042891 9 7 0,000 0,05225398 0,11185326 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,05225398 0,11175383 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05225398 0,11165459 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05225398 0,11155551 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05225398 0,11145662 ! aspartate family amino acid catabolic process GO:0009068 9 7 0,000 0,05225398 0,1113579 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,05225398 0,11125935 ! glycolipid catabolic process GO:0019377 15 7 0,000 0,05225398 0,11116098 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 10 7 0,000 0,05225398 0,11106278 ! positive regulation of ATPase activity GO:0032781 11 7 0,000 0,05225398 0,11096475 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05225398 0,1108669 ! endosome to lysosome transport GO:0008333 11 7 0,000 0,05225398 0,11076922 ! protein modification by small protein removal GO:0070646 16 7 0,000 0,05225398 0,11067171 ! adult feeding behavior GO:0008343 9 7 0,000 0,05225398 0,11057437 ! negative regulation of telomere maintenance GO:0032205 11 7 0,000 0,05225398 0,11047721 ! toll-like receptor signaling pathway GO:0002224 8 7 0,000 0,05225398 0,11038021 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,05225398 0,11028339 ! muscle adaptation GO:0043500 14 7 0,000 0,05225398 0,11018673 ! embryonic heart tube development GO:0035050 10 7 0,000 0,05225398 0,11009025 ! retina homeostasis GO:0001895 12 7 0,000 0,05225398 0,10999393 ! negative regulation of nucleotide metabolic process GO:0045980 11 7 0,000 0,05225398 0,10989778 ! fusion of sperm to egg plasma membrane GO:0007342 10 7 0,000 0,05225398 0,1098018 ! protein prenylation GO:0018342 18 7 0,000 0,05225398 0,10970599 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 15 7 0,000 0,05225398 0,10961034 ! regulation of microtubule polymerization GO:0031113 15 7 0,000 0,05225398 0,10951486 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05225398 0,10941955 ! regulation of action potential GO:0001508 95 49 1,000 0,05401964 0,11301848 ! regulation of protein complex disassembly GO:0043244 113 49 1,000 0,05401964 0,11292029 ! stress-activated protein kinase signaling pathway GO:0031098 97 49 1,000 0,05401964 0,11282227 ! response to temperature stimulus GO:0009266 76 49 1,000 0,05401964 0,11272442 ! DNA-dependent DNA replication GO:0006261 74 49 1,000 0,05401964 0,11262674 ! regulation of cell projection organization GO:0031344 121 50 1,000 0,05599479 0,11664369 ! histone modification GO:0016570 91 50 1,000 0,05599479 0,11654279 ! regulation of ossification GO:0030278 117 50 1,000 0,05599479 0,11644206 ! positive regulation of binding GO:0051099 78 51 1,000 0,05799497 0,12049731 ! response to estrogen stimulus GO:0043627 93 51 1,000 0,05799497 0,12039335 ! embryonic skeletal system development GO:0048706 85 51 1,000 0,05799497 0,12028956 ! vesicle organization GO:0016050 107 51 1,000 0,05799497 0,12018595 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 15 8 0,000 0,05949348 0,1231853 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 16 8 0,000 0,05949348 0,12307938 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 16 8 0,000 0,05949348 0,12297364 ! somatic diversification of immune receptors via somatic mutation GO:0002566 11 8 0,000 0,05949348 0,12286809 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 14 8 0,000 0,05949348 0,12276271 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05949348 0,12265752 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05949348 0,1225525 ! glycerol-3-phosphate metabolic process GO:0006072 13 8 0,000 0,05949348 0,12244766 ! neutral lipid catabolic process GO:0046461 13 8 0,000 0,05949348 0,12234301 ! regulation of cellular amine metabolic process GO:0033238 12 8 0,000 0,05949348 0,12223853 ! meiotic prophase I GO:0007128 13 8 0,000 0,05949348 0,12213423 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05949348 0,12203011 ! UTP metabolic process GO:0046051 8 8 0,000 0,05949348 0,12192617 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! signal peptide processing GO:0006465 12 8 0,000 0,05949348 0,1218224 ! prostaglandin biosynthetic process GO:0001516 14 8 0,000 0,05949348 0,12171881 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 14 8 0,000 0,05949348 0,1216154 ! succinate metabolic process GO:0006105 14 8 0,000 0,05949348 0,12151216 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05949348 0,12140909 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,05949348 0,1213062 ! negative regulation of muscle cell differentiation GO:0051148 15 8 0,000 0,05949348 0,12120349 ! regulation of response to extracellular stimulus GO:0032104 13 8 0,000 0,05949348 0,12110095 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05949348 0,12099858 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05949348 0,12089639 ! ganglioside metabolic process GO:0001573 19 8 0,000 0,05949348 0,12079436 ! reflex GO:0060004 16 8 0,000 0,05949348 0,12069251 ! negative regulation of endocytosis GO:0045806 11 8 0,000 0,05949348 0,12059083 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 14 8 0,000 0,05949348 0,12048933 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05949348 0,12038799 ! glycerol ether biosynthetic process GO:0046504 13 8 0,000 0,05949348 0,12028682 ! glycerolipid catabolic process GO:0046503 13 8 0,000 0,05949348 0,12018583 ! hemoglobin metabolic process GO:0020027 13 8 0,000 0,05949348 0,120085 ! regulation of defense response to virus by virus GO:0050690 18 8 0,000 0,05949348 0,11998434 ! astrocyte differentiation GO:0048708 18 8 0,000 0,05949348 0,11988385 ! histidine metabolic process GO:0006547 16 8 0,000 0,05949348 0,11978353 GO:0009075|histidine family amino acid metabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05949348 0,11968338 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 14 8 0,000 0,05949348 0,11958339 ! glycine catabolic process GO:0006546 13 8 0,000 0,05949348 0,11948357 ! cytoskeletal anchoring at plasma membrane GO:0007016 29 8 0,000 0,05949348 0,11938392 ! L-phenylalanine metabolic process GO:0006558 11 8 0,000 0,05949348 0,11928443 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 11 8 0,000 0,05949348 0,11918511 ! embryonic eye morphogenesis GO:0048048 14 8 0,000 0,05949348 0,11908596 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05949348 0,11898697 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05949348 0,11888814 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 15 8 0,000 0,05949348 0,11878948 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,05949348 0,11869098 ! synaptic transmission, glutamatergic GO:0035249 17 8 0,000 0,05949348 0,11859264 ! positive regulation of mesenchymal cell proliferation GO:0002053 27 8 0,000 0,05949348 0,11849447 ! regulation of multicellular organismal metabolic process GO:0044246 11 8 0,000 0,05949348 0,11839646 ! osteoblast development GO:0002076 16 8 0,000 0,05949348 0,11829861 ! positive regulation of vasodilation GO:0045909 13 8 0,000 0,05949348 0,11820092 ! negative regulation of muscle contraction GO:0045932 15 8 0,000 0,05949348 0,1181034 ! negative regulation of translational initiation GO:0045947 10 8 0,000 0,05949348 0,11800603 ! Schwann cell differentiation GO:0014037 19 8 0,000 0,05949348 0,11790883 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 19 8 0,000 0,05949348 0,11781179 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05949348 0,1177149 ! protein targeting to vacuole GO:0006623 12 8 0,000 0,05949348 0,11761818 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05949348 0,11752161 ! intermediate filament organization GO:0045109 12 8 0,000 0,05949348 0,1174252 ! cardiac muscle cell differentiation GO:0055007 27 8 0,000 0,05949348 0,11732895 ! positive regulation of myeloid leukocyte differentiation GO:0002763 24 8 0,000 0,05949348 0,11723286 ! cellular extravasation GO:0045123 12 8 0,000 0,05949348 0,11713692 ! cardiac muscle cell development GO:0055013 13 8 0,000 0,05949348 0,11704114 ! regulation of circadian rhythm GO:0042752 16 8 0,000 0,05949348 0,11694552 ! response to antibiotic GO:0046677 11 8 0,000 0,05949348 0,11685006 ! transcription-coupled nucleotide-excision repair GO:0006283 11 8 0,000 0,05949348 0,11675475 ! positive regulation of production of molecular mediator of immune response GO:0002702 25 8 0,000 0,05949348 0,11665959 ! DNA topological change GO:0006265 12 8 0,000 0,05949348 0,11656459 ! response to tropane GO:0014073 15 8 0,000 0,05949348 0,11646975 GO:0042220|response to cocaine, ! regulation of fat cell differentiation GO:0045598 15 8 0,000 0,05949348 0,11637506 ! melanosome transport GO:0032402 13 8 0,000 0,05949348 0,11628052 ! regulation of interleukin-4 production GO:0032673 17 8 0,000 0,05949348 0,11618614 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05949348 0,11609191 ! mast cell activation GO:0045576 14 8 0,000 0,05949348 0,11599783 ! multicellular organismal aging GO:0010259 18 8 0,000 0,05949348 0,1159039 ! dendrite morphogenesis GO:0048813 13 8 0,000 0,05949348 0,11581013 ! regulation of interleukin-1 production GO:0032652 13 8 0,000 0,05949348 0,11571651 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05949348 0,11562304 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05949348 0,11552972 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 16 8 0,000 0,05949348 0,11543655 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05949348 0,11534353 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05949348 0,11525066 ! establishment of chromosome localization GO:0051303 12 8 0,000 0,05949348 0,11515794 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 14 8 0,000 0,05949348 0,11506537 ! intracellular lipid transport GO:0032365 13 8 0,000 0,05949348 0,11497295 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05949348 0,11488067 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05949348 0,11478855 ! regulation of macrophage activation GO:0043030 15 8 0,000 0,05949348 0,11469657 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 15 8 0,000 0,05949348 0,11460474 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05949348 0,11451306 ! neuromuscular process controlling posture GO:0050884 14 8 0,000 0,05949348 0,11442152 ! regulation of synaptic transmission, glutamatergic GO:0051966 17 8 0,000 0,05949348 0,11433013 ! hormone catabolic process GO:0042447 17 8 0,000 0,05949348 0,11423888 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05949348 0,11414778 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 13 8 0,000 0,05949348 0,11405683 ! regulation of Rac protein signal transduction GO:0035020 11 8 0,000 0,05949348 0,11396602 ! ATP catabolic process GO:0006200 11 8 0,000 0,05949348 0,11387535 ! blastocyst growth GO:0001832 19 8 0,000 0,05949348 0,11378483 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,05949348 0,11369446 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05949348 0,11360422 ! pattern recognition receptor signaling pathway GO:0002221 10 8 0,000 0,05949348 0,11351413 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05949348 0,11342418 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05949348 0,11333438 ! regulation of synaptic transmission, GABAergic GO:0032228 14 8 0,000 0,05949348 0,11324472 ! negative regulation of blood vessel endothelial cell migration GO:0043537 21 8 0,000 0,05949348 0,11315519 ! positive regulation of NF-kappaB import into nucleus GO:0042346 13 8 0,000 0,05949348 0,11306581 ! pyrimidine nucleotide catabolic process GO:0006244 14 8 0,000 0,05949348 0,11297657 ! amino sugar catabolic process GO:0046348 10 8 0,000 0,05949348 0,11288748 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05949348 0,11279852 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05949348 0,1127097 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05949348 0,11262102 GO:0000076|DNA replication checkpoint, ! NAD biosynthetic process GO:0009435 13 8 0,000 0,05949348 0,11253248 ! positive regulation of growth GO:0045927 90 52 1,000 0,06001967 0,1134386 ! covalent chromatin modification GO:0016569 101 52 1,000 0,06001967 0,11334956 ! morphogenesis of a branching structure GO:0001763 111 52 1,000 0,06001967 0,11326066 ! synapse organization GO:0050808 85 52 1,000 0,06001967 0,11317189 ! nucleoside monophosphate biosynthetic process GO:0009124 85 53 1,000 0,06206843 0,11694333 ! activation of phospholipase C activity GO:0007202 103 54 1,000 0,06414074 0,12075323 GO:0010863|positive regulation of phospholipase C activity, ! negative regulation of cytoskeleton organization GO:0051494 124 54 1,000 0,06414074 0,12065882 ! cellular polysaccharide metabolic process GO:0044264 86 55 1,000 0,06623615 0,12450325 ! positive regulation of phospholipase activity GO:0010518 104 55 1,000 0,06623615 0,12440606 ! regulation of multicellular organism growth GO:0040014 85 55 1,000 0,06623615 0,12430902 ! nuclear export GO:0051168 97 55 1,000 0,06623615 0,12421213 ! regulation of developmental growth GO:0048638 15 9 0,000 0,06667793 0,12494322 ! axon extension GO:0048675 15 9 0,000 0,06667793 0,12484599 ! autophagic vacuole formation GO:0000045 15 9 0,000 0,06667793 0,12474891 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,06667793 0,12465198 ! 'de novo' posttranslational protein folding GO:0051084 14 9 0,000 0,06667793 0,1245552 ! regulation of epithelial cell differentiation GO:0030856 14 9 0,000 0,06667793 0,12445857 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06667793 0,12436209 GO:0006740|NADPH regeneration, ! associative learning GO:0008306 20 9 0,000 0,06667793 0,12426576 ! DNA synthesis during DNA repair GO:0000731 14 9 0,000 0,06667793 0,12416958 ! cell proliferation in forebrain GO:0021846 15 9 0,000 0,06667793 0,12407355 ! phosphate transport GO:0006817 19 9 0,000 0,06667793 0,12397766 ! reproductive behavior GO:0019098 19 9 0,000 0,06667793 0,12388193 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06667793 0,12378634 ! regulation of epidermal growth factor receptor activity GO:0007176 16 9 0,000 0,06667793 0,1236909 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06667793 0,12359561 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! Golgi to endosome transport GO:0006895 23 9 0,000 0,06667793 0,12350046 ! GTP metabolic process GO:0046039 9 9 0,000 0,06667793 0,12340546 ! RNA methylation GO:0001510 15 9 0,000 0,06667793 0,12331061 ! elastic fiber assembly GO:0048251 15 9 0,000 0,06667793 0,1232159 ! regulation of activated T cell proliferation GO:0046006 16 9 0,000 0,06667793 0,12312133 ! artery development GO:0060840 24 9 0,000 0,06667793 0,12302692 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 12 9 0,000 0,06667793 0,12293264 ! regulation of glycolysis GO:0006110 21 9 0,000 0,06667793 0,12283851 ! cerebral cortex cell migration GO:0021795 15 9 0,000 0,06667793 0,12274453 ! keratinocyte proliferation GO:0043616 14 9 0,000 0,06667793 0,12265069 ! chemosensory behavior GO:0007635 20 9 0,000 0,06667793 0,12255699 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,06667793 0,12246343 ! amyloid precursor protein metabolic process GO:0042982 14 9 0,000 0,06667793 0,12237002 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06667793 0,12227675 ! bile acid and bile salt transport GO:0015721 13 9 0,000 0,06667793 0,12218362 ! regulation of mesenchymal cell proliferation GO:0010464 28 9 0,000 0,06667793 0,12209064 ! positive regulation of gene expression, epigenetic GO:0045815 18 9 0,000 0,06667793 0,12199779 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06667793 0,12190509 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06667793 0,12181253 ! protein targeting to ER GO:0045047 22 9 0,000 0,06667793 0,1217201 ! ceramide biosynthetic process GO:0046513 19 9 0,000 0,06667793 0,12162782 ! nerve growth factor receptor signaling pathway GO:0048011 19 9 0,000 0,06667793 0,12153568 ! embryonic cranial skeleton morphogenesis GO:0048701 17 9 0,000 0,06667793 0,12144368 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06667793 0,12135181 GO:0006600|creatine metabolic process, ! endosome organization GO:0007032 17 9 0,000 0,06667793 0,12126009 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06667793 0,1211685 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06667793 0,12107706 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06667793 0,12098575 ! mannose metabolic process GO:0006013 13 9 0,000 0,06667793 0,12089457 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 21 9 0,000 0,06667793 0,12080354 ! retrograde transport, endosome to Golgi GO:0042147 24 9 0,000 0,06667793 0,12071264 ! Rac protein signal transduction GO:0016601 17 9 0,000 0,06667793 0,12062188 ! neurotransmitter catabolic process GO:0042135 15 9 0,000 0,06667793 0,12053125 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06667793 0,12044076 ! ruffle organization GO:0031529 15 9 0,000 0,06667793 0,12035041 ! retinol metabolic process GO:0042572 18 9 0,000 0,06667793 0,12026019 ! intestinal cholesterol absorption GO:0030299 16 9 0,000 0,06667793 0,12017011 ! determination of anterior/posterior axis, embryo GO:0008595 16 9 0,000 0,06667793 0,12008016 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 22 9 0,000 0,06667793 0,11999035 ! chondroitin sulfate biosynthetic process GO:0030206 17 9 0,000 0,06667793 0,11990067 GO:0030204|chondroitin sulfate metabolic process, ! protein heterooligomerization GO:0051291 16 9 0,000 0,06667793 0,11981113 ! oligodendrocyte development GO:0014003 10 9 0,000 0,06667793 0,11972172 ! segment specification GO:0007379 13 9 0,000 0,06667793 0,11963244 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06667793 0,11954329 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! base-excision repair, AP site formation GO:0006285 14 9 0,000 0,06667793 0,11945428 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06667793 0,1193654 ! response to amine stimulus GO:0014075 13 9 0,000 0,06667793 0,11927665 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06667793 0,11918804 ! nucleoside diphosphate metabolic process GO:0009132 13 9 0,000 0,06667793 0,11909955 ! erythrocyte development GO:0048821 15 9 0,000 0,06667793 0,1190112 ! gas homeostasis GO:0033483 16 9 0,000 0,06667793 0,11892298 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,06667793 0,11883489 ! renal water homeostasis GO:0003091 14 9 0,000 0,06667793 0,11874693 ! protein import into peroxisome matrix GO:0016558 16 9 0,000 0,06667793 0,1186591 ! spinal cord motor neuron differentiation GO:0021522 15 9 0,000 0,06667793 0,1185714 ! icosanoid secretion GO:0032309 15 9 0,000 0,06667793 0,11848382 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 14 9 0,000 0,06667793 0,11839638 ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06667793 0,11830907 GO:0021696|cerebellar cortex morphogenesis, ! synaptic vesicle endocytosis GO:0048488 20 9 0,000 0,06667793 0,11822189 ! regulation of cell division GO:0051302 15 9 0,000 0,06667793 0,11813483 ! retinal ganglion cell axon guidance GO:0031290 13 9 0,000 0,06667793 0,1180479 ! morphogenesis of a polarized epithelium GO:0001738 11 9 0,000 0,06667793 0,1179611 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06667793 0,11787443 ! sterol catabolic process GO:0016127 11 9 0,000 0,06667793 0,11778788 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06667793 0,11770147 ! negative regulation of cytokine secretion GO:0050710 14 9 0,000 0,06667793 0,11761517 ! S phase GO:0051320 9 9 0,000 0,06667793 0,11752901 GO:0000084|S phase of mitotic cell cycle, ! positive regulation of erythrocyte differentiation GO:0045648 29 9 0,000 0,06667793 0,11744297 ! regulation of macrophage differentiation GO:0045649 15 9 0,000 0,06667793 0,11735706 ! musculoskeletal movement GO:0050881 14 9 0,000 0,06667793 0,11727127 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 19 9 0,000 0,06667793 0,11718561 ! branched chain family amino acid catabolic process GO:0009083 17 9 0,000 0,06667793 0,11710007 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,06667793 0,11701466 ! purine base metabolic process GO:0006144 21 9 0,000 0,06667793 0,11692937 ! serine family amino acid catabolic process GO:0009071 16 9 0,000 0,06667793 0,11684421 ! pigment granule transport GO:0051904 17 9 0,000 0,06667793 0,11675917 ! regulation of fibrinolysis GO:0051917 16 9 0,000 0,06667793 0,11667425 ! regulation of telomere maintenance GO:0032204 14 9 0,000 0,06667793 0,11658946 ! pyrimidine base metabolic process GO:0006206 17 9 0,000 0,06667793 0,11650479 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,06667793 0,11642025 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06667793 0,11633582 ! mitochondrion localization GO:0051646 15 9 0,000 0,06667793 0,11625152 ! nucleotide-excision repair GO:0006289 83 56 1,000 0,06835417 0,11908771 ! regulation of phospholipase activity GO:0010517 106 57 1,000 0,07049434 0,12272748 ! regulation of endocytosis GO:0030100 91 58 1,000 0,07265621 0,12639973 ! positive regulation of lipase activity GO:0060193 108 58 1,000 0,07265621 0,1263084 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 21 10 0,000 0,07380773 0,12821762 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,07380773 0,12812511 ! negative regulation of lipid biosynthetic process GO:0051055 14 10 0,000 0,07380773 0,12803273 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,07380773 0,12794049 ! synapsis GO:0007129 13 10 0,000 0,07380773 0,12784838 GO:0070192|chromosome organization involved in meiosis, ! cell volume homeostasis GO:0006884 17 10 0,000 0,07380773 0,1277564 ! N-glycan processing GO:0006491 20 10 0,000 0,07380773 0,12766456 ! regulation of long-term neuronal synaptic plasticity GO:0048169 28 10 0,000 0,07380773 0,12757285 ! SMAD protein nuclear translocation GO:0007184 20 10 0,000 0,07380773 0,12748126 ! social behavior GO:0035176 24 10 0,000 0,07380773 0,12738981 ! COPI coating of Golgi vesicle GO:0048205 19 10 0,000 0,07380773 0,1272985 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 16 10 0,000 0,07380773 0,12720731 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 19 10 0,000 0,07380773 0,12711625 ! androgen metabolic process GO:0008209 17 10 0,000 0,07380773 0,12702532 ! phospholipid efflux GO:0033700 16 10 0,000 0,07380773 0,12693453 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,07380773 0,12684386 ! pathogenesis GO:0009405 13 10 0,000 0,07380773 0,12675332 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07380773 0,12666291 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 13 10 0,000 0,07380773 0,12657263 ! sphingoid biosynthetic process GO:0046520 21 10 0,000 0,07380773 0,12648248 ! regulation of S phase of mitotic cell cycle GO:0007090 17 10 0,000 0,07380773 0,12639246 ! endoderm development GO:0007492 16 10 0,000 0,07380773 0,12630256 ! positive regulation of survival gene product expression GO:0045885 23 10 0,000 0,07380773 0,12621279 ! arginine catabolic process GO:0006527 13 10 0,000 0,07380773 0,12612315 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,07380773 0,12603364 ! proline metabolic process GO:0006560 13 10 0,000 0,07380773 0,12594426 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,07380773 0,125855 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 18 10 0,000 0,07380773 0,12576587 ! polyamine biosynthetic process GO:0006596 12 10 0,000 0,07380773 0,12567686 ! V(D)J recombination GO:0033151 28 10 0,000 0,07380773 0,12558798 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07380773 0,12549922 ! central nervous system neuron axonogenesis GO:0021955 22 10 0,000 0,07380773 0,12541059 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 30 10 0,000 0,07380773 0,12532209 ! nucleobase biosynthetic process GO:0046112 24 10 0,000 0,07380773 0,12523371 ! regulation of sodium ion transport GO:0002028 21 10 0,000 0,07380773 0,12514546 ! multicellular organism growth GO:0035264 18 10 0,000 0,07380773 0,12505733 ! phagocytosis, engulfment GO:0006911 28 10 0,000 0,07380773 0,12496932 ! neurotransmitter biosynthetic process GO:0042136 16 10 0,000 0,07380773 0,12488144 ! epithelial cell development GO:0002064 20 10 0,000 0,07380773 0,12479368 ! lens development in camera-type eye GO:0002088 16 10 0,000 0,07380773 0,12470604 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,07380773 0,12461853 ! macroautophagy GO:0016236 17 10 0,000 0,07380773 0,12453114 ! positive regulation of translational initiation GO:0045948 11 10 0,000 0,07380773 0,12444387 ! positive regulation vascular endothelial growth factor production GO:0010575 22 10 0,000 0,07380773 0,12435672 ! regulation of smoothened signaling pathway GO:0008589 23 10 0,000 0,07380773 0,1242697 ! copper ion homeostasis GO:0055070 13 10 0,000 0,07380773 0,1241828 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,07380773 0,12409602 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,07380773 0,12400936 ! negative regulation of axonogenesis GO:0050771 32 10 0,000 0,07380773 0,12392282 ! positive regulation of phagocytosis GO:0050766 13 10 0,000 0,07380773 0,1238364 ! blastoderm segmentation GO:0007350 18 10 0,000 0,07380773 0,12375011 ! DNA ligation GO:0006266 19 10 0,000 0,07380773 0,12366393 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07380773 0,12357787 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,07380773 0,12349193 ! melanosome localization GO:0032400 16 10 0,000 0,07380773 0,12340612 ! glycosphingolipid biosynthetic process GO:0006688 15 10 0,000 0,07380773 0,12332042 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,07380773 0,12323484 ! positive regulation of Rho GTPase activity GO:0032321 24 10 0,000 0,07380773 0,12314938 ! mRNA cleavage GO:0006379 17 10 0,000 0,07380773 0,12306403 ! protein sumoylation GO:0016925 15 10 0,000 0,07380773 0,12297881 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,07380773 0,1228937 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07380773 0,12280871 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,07380773 0,12272384 ! cellular metabolic compound salvage GO:0043094 14 10 0,000 0,07380773 0,12263909 ! positive regulation of interleukin-1 beta secretion GO:0050718 13 10 0,000 0,07380773 0,12255445 ! salivary gland development GO:0007431 27 10 0,000 0,07380773 0,12246993 ! prophase GO:0051324 15 10 0,000 0,07380773 0,12238553 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07380773 0,12230124 ! apical protein localization GO:0045176 15 10 0,000 0,07380773 0,12221707 ! ubiquinone metabolic process GO:0006743 15 10 0,000 0,07380773 0,12213301 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 16 10 0,000 0,07380773 0,12204907 ! midbrain development GO:0030901 13 10 0,000 0,07380773 0,12196525 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07380773 0,12188154 ! methionine biosynthetic process GO:0009086 19 10 0,000 0,07380773 0,12179794 ! nicotinamide nucleotide biosynthetic process GO:0019359 16 10 0,000 0,07380773 0,12171446 ! quaternary ammonium group transport GO:0015697 21 10 0,000 0,07380773 0,1216311 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,07380773 0,12154785 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,07380773 0,12146471 ! positive regulation of viral reproduction GO:0048524 18 10 0,000 0,07380773 0,12138168 ! regulation of cellular carbohydrate catabolic process GO:0043471 22 10 0,000 0,07380773 0,12129877 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 23 10 0,000 0,07380773 0,12121597 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,07380773 0,12113329 ! cerebellar cortex development GO:0021695 15 10 0,000 0,07380773 0,12105072 ! establishment or maintenance of apical/basal cell polarity GO:0035088 22 10 0,000 0,07380773 0,12096826 ! activation of innate immune response GO:0002218 12 10 0,000 0,07380773 0,12088591 GO:0002758|innate immune response-activating signal transduction, ! natural killer cell mediated immunity GO:0002228 18 10 0,000 0,07380773 0,12080367 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 16 10 0,000 0,07380773 0,12072155 ! DNA catabolic process GO:0006308 86 59 1,000 0,07483932 0,12232567 ! establishment of organelle localization GO:0051656 109 59 1,000 0,07483932 0,12224263 ! kidney development GO:0001822 122 60 1,000 0,07704322 0,12575711 ! respiratory burst GO:0045730 17 11 0,000 0,0808833 0,13193575 ! very-long-chain fatty acid metabolic process GO:0000038 19 11 0,000 0,0808833 0,13184636 ! neuron fate specification GO:0048665 17 11 0,000 0,0808833 0,13175709 ! telencephalon cell migration GO:0022029 20 11 0,000 0,0808833 0,13166795 ! positive regulation of small GTPase mediated signal transduction GO:0051057 19 11 0,000 0,0808833 0,13157892 GO:0046579|positive regulation of Ras protein signal transduction, ! cortical actin cytoskeleton organization GO:0030866 30 11 0,000 0,0808833 0,13149002 ! thyroid gland development GO:0030878 26 11 0,000 0,0808833 0,13140123 ! glycosaminoglycan catabolic process GO:0006027 13 11 0,000 0,0808833 0,13131257 ! Golgi vesicle budding GO:0048194 22 11 0,000 0,0808833 0,13122402 ! response to pain GO:0048265 24 11 0,000 0,0808833 0,1311356 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,0808833 0,13104729 ! bone resorption GO:0045453 16 11 0,000 0,0808833 0,1309591 ! ventral spinal cord development GO:0021517 21 11 0,000 0,0808833 0,13087103 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,0808833 0,13078308 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,0808833 0,13069525 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 18 11 0,000 0,0808833 0,13060753 ! melanocyte differentiation GO:0030318 21 11 0,000 0,0808833 0,13051994 GO:0050931|pigment cell differentiation, ! telomere maintenance via telomerase GO:0007004 21 11 0,000 0,0808833 0,13043246 GO:0010833|telomere maintenance via telomere lengthening, ! indolalkylamine metabolic process GO:0006586 17 11 0,000 0,0808833 0,13034509 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of Cdc42 protein signal transduction GO:0032489 21 11 0,000 0,0808833 0,13025785 GO:0043088|regulation of Cdc42 GTPase activity, ! lipid digestion GO:0044241 18 11 0,000 0,0808833 0,13017072 ! substrate-bound cell migration GO:0006929 13 11 0,000 0,0808833 0,13008371 ! UV protection GO:0009650 19 11 0,000 0,0808833 0,12999681 ! adult heart development GO:0007512 14 11 0,000 0,0808833 0,12991003 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,0808833 0,12982337 ! temperature homeostasis GO:0001659 17 11 0,000 0,0808833 0,12973682 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 23 11 0,000 0,0808833 0,12965038 ! regulation of vascular endothelial growth factor production GO:0010574 23 11 0,000 0,0808833 0,12956407 ! positive regulation of peptide secretion GO:0002793 22 11 0,000 0,0808833 0,12947786 ! regulation of organ growth GO:0046620 13 11 0,000 0,0808833 0,12939177 ! pigment granule localization GO:0051875 20 11 0,000 0,0808833 0,1293058 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,0808833 0,12921994 ! embryonic axis specification GO:0000578 18 11 0,000 0,0808833 0,12913419 ! sphingomyelin metabolic process GO:0006684 15 11 0,000 0,0808833 0,12904856 ! snRNA metabolic process GO:0016073 24 11 0,000 0,0808833 0,12896304 GO:0016180|snRNA processing, ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,0808833 0,12887763 ! nitric oxide metabolic process GO:0046209 15 11 0,000 0,0808833 0,12879234 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,0808833 0,12870716 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 15 11 0,000 0,0808833 0,12862209 ! zymogen activation GO:0031638 15 11 0,000 0,0808833 0,12853714 ! positive regulation of interleukin-1 secretion GO:0050716 14 11 0,000 0,0808833 0,12845229 ! neuroblast proliferation GO:0007405 24 11 0,000 0,0808833 0,12836756 ! nucleosome positioning GO:0016584 15 11 0,000 0,0808833 0,12828294 ! regulation of interleukin-1 beta secretion GO:0050706 15 11 0,000 0,0808833 0,12819844 ! glutathione biosynthetic process GO:0006750 13 11 0,000 0,0808833 0,12811404 ! acid secretion GO:0046717 18 11 0,000 0,0808833 0,12802975 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,0808833 0,12794558 ! positive regulation of neuron differentiation GO:0045666 19 11 0,000 0,0808833 0,12786152 ! nitric oxide mediated signal transduction GO:0007263 23 11 0,000 0,0808833 0,12777756 ! regulation of T-helper 2 cell differentiation GO:0045628 20 11 0,000 0,0808833 0,12769372 ! somatic diversification of immunoglobulins during immune response GO:0002208 22 11 0,000 0,0808833 0,12760998 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 19 11 0,000 0,0808833 0,12752636 ! anterior/posterior axis specification GO:0009948 18 11 0,000 0,0808833 0,12744285 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,0808833 0,12735944 ! germ cell migration GO:0008354 25 11 0,000 0,0808833 0,12727615 ! embryonic gut development GO:0048566 15 11 0,000 0,0808833 0,12719296 ! regulation of organic acid transport GO:0032890 18 11 0,000 0,0808833 0,12710988 ! regulation of actin filament bundle formation GO:0032231 33 11 0,000 0,0808833 0,12702691 ! cardiac cell differentiation GO:0035051 31 11 0,000 0,0808833 0,12694405 ! defense response to Gram-positive bacterium GO:0050830 13 11 0,000 0,0808833 0,12686129 ! defense response to fungus GO:0050832 13 11 0,000 0,0808833 0,12677865 ! developmental induction GO:0031128 19 11 0,000 0,0808833 0,12669611 GO:0045168|cell-cell signaling involved in cell fate specification, ! lysogeny GO:0030069 21 11 0,000 0,0808833 0,12661368 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,0808833 0,12653136 ! sequestering of metal ion GO:0051238 14 11 0,000 0,0808833 0,12644914 ! lamellipodium assembly GO:0030032 20 11 0,000 0,0808833 0,12636703 ! regulation of embryonic development GO:0045995 27 11 0,000 0,0808833 0,12628503 ! nucleus localization GO:0051647 19 11 0,000 0,0808833 0,12620313 ! regulation of synapse organization GO:0050807 17 11 0,000 0,0808833 0,12612134 ! ear development GO:0043583 103 62 1,000 0,08151165 0,1270188 ! regulation of mitosis GO:0007088 105 63 1,000 0,08377531 0,13046175 GO:0051783|regulation of nuclear division, ! nucleoside monophosphate metabolic process GO:0009123 107 63 1,000 0,08377531 0,13037736 ! steroid hormone receptor signaling pathway GO:0030518 129 63 1,000 0,08377531 0,13029308 ! oxygen and reactive oxygen species metabolic process GO:0006800 93 64 1,000 0,08605803 0,13375686 ! multicellular organism reproduction GO:0032504 111 64 1,000 0,08605803 0,13367051 GO:0048609|reproductive process in a multicellular organism, ! negative regulation of cell projection organization GO:0031345 37 12 0,000 0,08790505 0,13645133 ! regulation of membrane protein ectodomain proteolysis GO:0051043 22 12 0,000 0,08790505 0,13636335 ! positive regulation of blood pressure GO:0045777 17 12 0,000 0,08790505 0,13627549 ! positive regulation of cellular catabolic process GO:0031331 31 12 0,000 0,08790505 0,13618774 ! cortical cytoskeleton organization GO:0030865 31 12 0,000 0,08790505 0,1361001 ! virus-host interaction GO:0019048 29 12 0,000 0,08790505 0,13601258 ! folic acid and derivative biosynthetic process GO:0009396 21 12 0,000 0,08790505 0,13592517 ! mating GO:0007618 17 12 0,000 0,08790505 0,13583787 ! protein complex disassembly GO:0043241 27 12 0,000 0,08790505 0,13575068 GO:0043624|cellular protein complex disassembly, ! hippocampus development GO:0021766 26 12 0,000 0,08790505 0,1356636 ! cytokine biosynthetic process GO:0042089 21 12 0,000 0,08790505 0,13557664 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08790505 0,13548979 ! positive regulation of cell growth GO:0030307 22 12 0,000 0,08790505 0,13540305 ! regulation of interferon-gamma biosynthetic process GO:0045072 16 12 0,000 0,08790505 0,13531642 ! regulation of exit from mitosis GO:0007096 17 12 0,000 0,08790505 0,1352299 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 24 12 0,000 0,08790505 0,13514349 ! glycolipid biosynthetic process GO:0009247 17 12 0,000 0,08790505 0,13505719 ! drug transport GO:0015893 16 12 0,000 0,08790505 0,134971 ! nucleotide-sugar metabolic process GO:0009225 19 12 0,000 0,08790505 0,13488492 ! oligodendrocyte differentiation GO:0048709 16 12 0,000 0,08790505 0,13479895 ! tyrosine metabolic process GO:0006570 16 12 0,000 0,08790505 0,1347131 ! polyamine metabolic process GO:0006595 17 12 0,000 0,08790505 0,13462735 ! mitotic spindle organization GO:0007052 21 12 0,000 0,08790505 0,1345417 ! negative regulation of endothelial cell migration GO:0010596 25 12 0,000 0,08790505 0,13445617 ! forebrain cell migration GO:0021885 21 12 0,000 0,08790505 0,13437075 ! asymmetric protein localization GO:0008105 20 12 0,000 0,08790505 0,13428543 ! regulation of calcium ion transport into cytosol GO:0010522 16 12 0,000 0,08790505 0,13420023 ! entry into host cell GO:0030260 32 12 0,000 0,08790505 0,13411513 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! monoamine transport GO:0015844 18 12 0,000 0,08790505 0,13403014 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08790505 0,13394526 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! L-glutamate transport GO:0015813 22 12 0,000 0,08790505 0,13386048 GO:0015800|acidic amino acid transport, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 24 12 0,000 0,08790505 0,13377581 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 19 12 0,000 0,08790505 0,13369125 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08790505 0,1336068 ! protein targeting to peroxisome GO:0006625 23 12 0,000 0,08790505 0,13352245 ! protein homotetramerization GO:0051289 21 12 0,000 0,08790505 0,13343821 ! negative regulation of myeloid leukocyte differentiation GO:0002762 16 12 0,000 0,08790505 0,13335407 ! regulation of phagocytosis GO:0050764 16 12 0,000 0,08790505 0,13327004 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08790505 0,13318612 ! synaptic vesicle exocytosis GO:0016079 19 12 0,000 0,08790505 0,1331023 ! regulation of interleukin-8 production GO:0032677 20 12 0,000 0,08790505 0,13301859 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08790505 0,13293498 ! cranial nerve development GO:0021545 20 12 0,000 0,08790505 0,13285148 ! fucose catabolic process GO:0019317 22 12 0,000 0,08790505 0,13276808 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 23 12 0,000 0,08790505 0,13268479 ! histone methylation GO:0016571 26 12 0,000 0,08790505 0,1326016 ! mRNA polyadenylation GO:0006378 23 12 0,000 0,08790505 0,13251852 ! autonomic nervous system development GO:0048483 24 12 0,000 0,08790505 0,13243554 ! regulation of hormone metabolic process GO:0032350 26 12 0,000 0,08790505 0,13235267 ! regulation of interleukin-1 secretion GO:0050704 16 12 0,000 0,08790505 0,13226989 ! aromatic amino acid family catabolic process GO:0009074 18 12 0,000 0,08790505 0,13218722 ! biogenic amine catabolic process GO:0042402 23 12 0,000 0,08790505 0,13210466 ! leukocyte mediated cytotoxicity GO:0001909 26 12 0,000 0,08790505 0,1320222 ! regulation of RNA splicing GO:0043484 20 12 0,000 0,08790505 0,13193984 ! quinone cofactor metabolic process GO:0042375 18 12 0,000 0,08790505 0,13185758 ! positive regulation of calcium-mediated signaling GO:0050850 24 12 0,000 0,08790505 0,13177543 ! response to cold GO:0009409 17 12 0,000 0,08790505 0,13169337 ! regulation of synapse structure and activity GO:0050803 18 12 0,000 0,08790505 0,13161142 ! regulation of steroid biosynthetic process GO:0050810 17 12 0,000 0,08790505 0,13152958 ! embryonic limb morphogenesis GO:0030326 125 65 1,000 0,08835939 0,13212722 GO:0035113|embryonic appendage morphogenesis, ! germ cell development GO:0007281 118 65 1,000 0,08835939 0,13204516 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 113 66 1,000 0,09067898 0,13542745 ! secondary metabolic process GO:0019748 116 66 1,000 0,09067898 0,13534344 ! cell projection assembly GO:0030031 120 66 1,000 0,09067898 0,13525953 ! regulation of cellular response to stress GO:0080135 128 67 1,000 0,09301638 0,13866011 ! cellular hormone metabolic process GO:0034754 113 67 1,000 0,09301638 0,13857425 ! homeostasis of number of cells GO:0048872 114 67 1,000 0,09301638 0,1384885 ! positive regulation of T cell activation GO:0050870 109 67 1,000 0,09301638 0,13840286 ! adaptive immune response GO:0002250 119 67 1,000 0,09301638 0,13831732 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! activation of immune response GO:0002253 105 67 1,000 0,09301638 0,13823188 ! cGMP metabolic process GO:0046068 18 13 0,000 0,09487339 0,14090456 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 25 13 0,000 0,09487339 0,14081763 ! regulation of chemokine production GO:0032642 18 13 0,000 0,09487339 0,14073082 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,09487339 0,1406441 GO:0000725|recombinational repair, ! peroxisomal transport GO:0043574 24 13 0,000 0,09487339 0,1405575 ! lipid localization GO:0010876 28 13 0,000 0,09487339 0,140471 GO:0019915|lipid storage, ! organelle fusion GO:0048284 32 13 0,000 0,09487339 0,14038461 ! positive regulation of lipid metabolic process GO:0045834 25 13 0,000 0,09487339 0,14029833 ! negative regulation of lipid metabolic process GO:0045833 19 13 0,000 0,09487339 0,14021215 ! pseudouridine synthesis GO:0001522 17 13 0,000 0,09487339 0,14012608 ! endocrine pancreas development GO:0031018 22 13 0,000 0,09487339 0,14004011 ! two-component signal transduction system (phosphorelay) GO:0000160 17 13 0,000 0,09487339 0,13995425 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 23 13 0,000 0,09487339 0,13986849 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 25 13 0,000 0,09487339 0,13978284 ! methionine metabolic process GO:0006555 27 13 0,000 0,09487339 0,1396973 ! plasma membrane organization GO:0007009 24 13 0,000 0,09487339 0,13961185 ! deoxyribonucleotide catabolic process GO:0009264 19 13 0,000 0,09487339 0,13952652 ! ribonucleotide catabolic process GO:0009261 20 13 0,000 0,09487339 0,13944128 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 27 13 0,000 0,09487339 0,13935616 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 24 13 0,000 0,09487339 0,13927113 ! cytokine metabolic process GO:0042107 22 13 0,000 0,09487339 0,13918621 ! cellular carbohydrate catabolic process GO:0044275 15 13 0,000 0,09487339 0,13910139 ! exocrine system development GO:0035272 32 13 0,000 0,09487339 0,13901668 ! positive regulation of carbohydrate metabolic process GO:0045913 24 13 0,000 0,09487339 0,13893206 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! heparan sulfate proteoglycan metabolic process GO:0030201 28 13 0,000 0,09487339 0,13884756 ! cotranslational protein targeting to membrane GO:0006613 24 13 0,000 0,09487339 0,13876315 ! regulation of cytokine production during immune response GO:0002718 23 13 0,000 0,09487339 0,13867885 ! regulation of natural killer cell mediated immunity GO:0002715 27 13 0,000 0,09487339 0,13859465 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 21 13 0,000 0,09487339 0,13851055 ! RNA-dependent DNA replication GO:0006278 23 13 0,000 0,09487339 0,13842655 ! nucleoside triphosphate catabolic process GO:0009143 21 13 0,000 0,09487339 0,13834266 ! cell wall macromolecule catabolic process GO:0016998 14 13 0,000 0,09487339 0,13825886 ! ribosome assembly GO:0042255 17 13 0,000 0,09487339 0,13817517 ! gastrulation with mouth forming second GO:0001702 25 13 0,000 0,09487339 0,13809158 ! positive regulation of Ras GTPase activity GO:0032320 35 13 0,000 0,09487339 0,13800809 ! chromatin silencing GO:0006342 26 13 0,000 0,09487339 0,1379247 ! regulation of acute inflammatory response GO:0002673 21 13 0,000 0,09487339 0,13784141 ! regulation of epidermis development GO:0045682 19 13 0,000 0,09487339 0,13775823 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09487339 0,13767514 ! serine family amino acid biosynthetic process GO:0009070 17 13 0,000 0,09487339 0,13759215 ! pyridine nucleotide biosynthetic process GO:0019363 19 13 0,000 0,09487339 0,13750927 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,09487339 0,13742648 ! regulation of fatty acid oxidation GO:0046320 27 13 0,000 0,09487339 0,13734379 ! positive regulation of homeostatic process GO:0032846 21 13 0,000 0,09487339 0,1372612 ! mRNA 3'-end processing GO:0031124 24 13 0,000 0,09487339 0,13717872 ! regulation of calcium-mediated signaling GO:0050848 25 13 0,000 0,09487339 0,13709633 ! embryonic placenta development GO:0001892 23 13 0,000 0,09487339 0,13701404 ! positive regulation of protein polymerization GO:0032273 25 13 0,000 0,09487339 0,13693184 ! insulin secretion GO:0030073 23 13 0,000 0,09487339 0,13684975 ! actin filament polymerization GO:0030041 24 13 0,000 0,09487339 0,13676775 ! acrosome reaction GO:0007340 18 13 0,000 0,09487339 0,13668586 ! negative regulation of ligase activity GO:0051352 112 68 1,000 0,0953712 0,13732083 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! intracellular receptor-mediated signaling pathway GO:0030522 139 68 1,000 0,0953712 0,1372387 ! regulation of lipase activity GO:0060191 130 68 1,000 0,0953712 0,13715667 ! cAMP-mediated signaling GO:0019933 120 69 1,000 0,09774303 0,14048371 ! appendage morphogenesis GO:0035107 135 70 1,000 0,10013147 0,14383064 GO:0035108|limb morphogenesis, ! lactation GO:0007595 26 14 0,000 0,10178872 0,14612391 ! reproductive cellular process GO:0048610 20 14 0,000 0,10178872 0,14603677 ! tRNA modification GO:0006400 20 14 0,000 0,10178872 0,14594974 ! pteridine and derivative biosynthetic process GO:0042559 19 14 0,000 0,10178872 0,14586282 ! water transport GO:0006833 21 14 0,000 0,10178872 0,14577599 GO:0042044|fluid transport, ! non-recombinational repair GO:0000726 25 14 0,000 0,10178872 0,14568927 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 25 14 0,000 0,10178872 0,14560266 ! retina development in camera-type eye GO:0060041 27 14 0,000 0,10178872 0,14551614 ! RNA polyadenylation GO:0043631 30 14 0,000 0,10178872 0,14542973 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 20 14 0,000 0,10178872 0,14534342 ! palate development GO:0060021 31 14 0,000 0,10178872 0,14525722 ! regulated secretory pathway GO:0045055 23 14 0,000 0,10178872 0,14517111 ! regulation of mRNA processing GO:0050684 24 14 0,000 0,10178872 0,14508511 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 19 14 0,000 0,10178872 0,14499921 ! arginine metabolic process GO:0006525 17 14 0,000 0,10178872 0,14491341 ! organic alcohol transport GO:0015850 29 14 0,000 0,10178872 0,14482772 ! negative regulation of caspase activity GO:0043154 22 14 0,000 0,10178872 0,14474212 ! embryo implantation GO:0007566 30 14 0,000 0,10178872 0,14465663 ! neutral amino acid transport GO:0015804 26 14 0,000 0,10178872 0,14457123 ! L-amino acid transport GO:0015807 30 14 0,000 0,10178872 0,14448594 ! bone mineralization GO:0030282 17 14 0,000 0,10178872 0,14440075 ! stem cell development GO:0048864 43 14 0,000 0,10178872 0,14431566 GO:0019827|stem cell maintenance, ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10178872 0,14423066 ! cerebellum development GO:0021549 21 14 0,000 0,10178872 0,14414577 ! regulation of T-helper 2 type immune response GO:0002828 24 14 0,000 0,10178872 0,14406098 ! negative regulation of protein secretion GO:0050709 28 14 0,000 0,10178872 0,14397629 ! positive regulation of bone mineralization GO:0030501 29 14 0,000 0,10178872 0,1438917 ! cofactor transport GO:0051181 26 14 0,000 0,10178872 0,1438072 ! NADP metabolic process GO:0006739 24 14 0,000 0,10178872 0,14372281 ! regulation of erythrocyte differentiation GO:0045646 44 14 0,000 0,10178872 0,14363852 ! protein-chromophore linkage GO:0018298 19 14 0,000 0,10178872 0,14355432 ! intestinal absorption GO:0050892 25 14 0,000 0,10178872 0,14347022 ! oxygen transport GO:0015671 21 14 0,000 0,10178872 0,14338622 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,10178872 0,14330232 ! male genitalia development GO:0030539 24 14 0,000 0,10178872 0,14321852 ! regulation of axon extension GO:0030516 37 14 0,000 0,10178872 0,14313481 ! cell wall macromolecule metabolic process GO:0044036 15 14 0,000 0,10178872 0,14305121 ! appendage development GO:0048736 136 71 1,000 0,10253615 0,1440175 GO:0060173|limb development, ! humoral immune response GO:0006959 109 71 1,000 0,10253615 0,14393347 ! regulation of immune effector process GO:0002697 137 71 1,000 0,10253615 0,14384955 ! regulation of blood pressure GO:0008217 125 73 1,000 0,10739265 0,15057501 ! axon guidance GO:0007411 139 73 1,000 0,10739265 0,15048731 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,10865145 0,15216262 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! positive regulation of cell size GO:0045793 27 15 0,000 0,10865145 0,1520741 ! superoxide anion generation GO:0042554 20 15 0,000 0,10865145 0,15198569 ! embryonic hindlimb morphogenesis GO:0035116 33 15 0,000 0,10865145 0,15189738 ! phospholipid catabolic process GO:0009395 22 15 0,000 0,10865145 0,15180917 ! copper ion transport GO:0006825 20 15 0,000 0,10865145 0,15172106 ! heterophilic cell adhesion GO:0007157 39 15 0,000 0,10865145 0,15163305 ! cardiac muscle contraction GO:0060048 26 15 0,000 0,10865145 0,15154515 ! sulfate transport GO:0008272 23 15 0,000 0,10865145 0,15145735 ! response to cAMP GO:0051591 22 15 0,000 0,10865145 0,15136965 ! regulation of excitatory postsynaptic membrane potential GO:0060079 27 15 0,000 0,10865145 0,15128205 ! negative regulation of cytokine biosynthetic process GO:0042036 23 15 0,000 0,10865145 0,15119455 ! ciliary or flagellar motility GO:0001539 20 15 0,000 0,10865145 0,15110716 ! isoprenoid biosynthetic process GO:0008299 32 15 0,000 0,10865145 0,15101986 ! response to hexose stimulus GO:0009746 22 15 0,000 0,10865145 0,15093267 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide metabolic process GO:0009218 21 15 0,000 0,10865145 0,15084558 ! glycoprotein catabolic process GO:0006516 26 15 0,000 0,10865145 0,15075858 ! pituitary gland development GO:0021983 29 15 0,000 0,10865145 0,15067169 ! vesicle coating GO:0006901 33 15 0,000 0,10865145 0,1505849 ! preassembly of GPI anchor in ER membrane GO:0016254 25 15 0,000 0,10865145 0,15049821 ! regulation of exocytosis GO:0017157 22 15 0,000 0,10865145 0,15041161 ! positive regulation of axonogenesis GO:0050772 28 15 0,000 0,10865145 0,15032512 ! positive regulation of biomineral formation GO:0070169 30 15 0,000 0,10865145 0,15023873 ! regulation of vasodilation GO:0042312 26 15 0,000 0,10865145 0,15015243 ! histone deacetylation GO:0016575 20 15 0,000 0,10865145 0,15006624 ! mRNA splice site selection GO:0006376 38 15 0,000 0,10865145 0,14998014 ! tissue regeneration GO:0042246 26 15 0,000 0,10865145 0,14989414 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,10865145 0,14980824 ! water homeostasis GO:0030104 27 15 0,000 0,10865145 0,14972244 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,10865145 0,14963674 ! muscle maintenance GO:0046716 26 15 0,000 0,10865145 0,14955113 ! regulation of T-helper cell differentiation GO:0045622 26 15 0,000 0,10865145 0,14946563 ! regulation of ATPase activity GO:0043462 21 15 0,000 0,10865145 0,14938022 ! dopamine metabolic process GO:0042417 35 15 0,000 0,10865145 0,14929491 ! heme biosynthetic process GO:0006783 29 15 0,000 0,10865145 0,14920969 ! cell killing GO:0001906 29 15 0,000 0,10865145 0,14912458 ! detection of bacterium GO:0016045 18 15 0,000 0,10865145 0,14903956 ! epithelial to mesenchymal transition GO:0001837 28 15 0,000 0,10865145 0,14895463 ! positive regulation of calcium ion transport GO:0051928 19 15 0,000 0,10865145 0,14886981 ! L-fucose metabolic process GO:0042354 30 15 0,000 0,10865145 0,14878508 ! regulation of NF-kappaB import into nucleus GO:0042345 29 15 0,000 0,10865145 0,14870045 ! peptide hormone processing GO:0016486 23 15 0,000 0,10865145 0,14861591 ! meiosis GO:0007126 121 74 1,000 0,10984373 0,15016137 GO:0051327|M phase of meiotic cell cycle, ! organelle localization GO:0051640 136 74 1,000 0,10984373 0,15007609 ! regulation of vesicle-mediated transport GO:0060627 119 75 1,000 0,11230952 0,15335795 ! meiotic cell cycle GO:0051321 122 75 1,000 0,11230952 0,15327096 ! rhythmic process GO:0048511 128 75 1,000 0,11230952 0,15318407 ! steroid biosynthetic process GO:0006694 131 76 1,000 0,11478967 0,15647815 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,11546196 0,15730548 ! sulfur amino acid biosynthetic process GO:0000097 28 16 0,000 0,11546196 0,15721646 ! dicarboxylic acid transport GO:0006835 38 16 0,000 0,11546196 0,15712754 ! bone remodeling GO:0046849 27 16 0,000 0,11546196 0,15703871 ! filopodium assembly GO:0046847 32 16 0,000 0,11546196 0,15694999 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 21 16 0,000 0,11546196 0,15686137 ! regulation of neurotransmitter secretion GO:0046928 33 16 0,000 0,11546196 0,15677285 ! positive regulation of ion transport GO:0043270 21 16 0,000 0,11546196 0,15668443 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 32 16 0,000 0,11546196 0,1565961 ! startle response GO:0001964 28 16 0,000 0,11546196 0,15650788 ! auditory receptor cell differentiation GO:0042491 32 16 0,000 0,11546196 0,15641976 ! negative regulation of endothelial cell proliferation GO:0001937 36 16 0,000 0,11546196 0,15633173 ! regulation of interleukin-2 biosynthetic process GO:0045076 28 16 0,000 0,11546196 0,15624381 ! activation of MAPKK activity GO:0000186 35 16 0,000 0,11546196 0,15615598 ! regulation of defense response to virus GO:0050688 27 16 0,000 0,11546196 0,15606825 ! induction of apoptosis via death domain receptors GO:0008625 20 16 0,000 0,11546196 0,15598062 ! protein polyubiquitination GO:0000209 34 16 0,000 0,11546196 0,15589309 ! glutamate metabolic process GO:0006536 22 16 0,000 0,11546196 0,15580566 ! complement activation, alternative pathway GO:0006957 18 16 0,000 0,11546196 0,15571832 ! response to osmotic stress GO:0006970 25 16 0,000 0,11546196 0,15563108 ! lysosomal transport GO:0007041 26 16 0,000 0,11546196 0,15554395 ! fructose metabolic process GO:0006000 25 16 0,000 0,11546196 0,1554569 ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,11546196 0,15536996 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,11546196 0,15528311 ! NLS-bearing substrate import into nucleus GO:0006607 46 16 0,000 0,11546196 0,15519636 ! embryonic digit morphogenesis GO:0042733 34 16 0,000 0,11546196 0,15510971 ! nucleotide-excision repair, DNA gap filling GO:0006297 24 16 0,000 0,11546196 0,15502315 ! neuron recognition GO:0008038 35 16 0,000 0,11546196 0,15493669 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 27 16 0,000 0,11546196 0,15485033 ! cellular amino acid derivative catabolic process GO:0042219 29 16 0,000 0,11546196 0,15476406 ! positive regulation of cytokine secretion GO:0050715 26 16 0,000 0,11546196 0,15467789 ! negative regulation of inflammatory response GO:0050728 22 16 0,000 0,11546196 0,15459181 ! sphingolipid catabolic process GO:0030149 27 16 0,000 0,11546196 0,15450583 GO:0046466|membrane lipid catabolic process, ! biomineral formation GO:0031214 20 16 0,000 0,11546196 0,15441995 ! neuromuscular synaptic transmission GO:0007274 33 16 0,000 0,11546196 0,15433416 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,11546196 0,15424847 ! aspartate family amino acid biosynthetic process GO:0009067 27 16 0,000 0,11546196 0,15416287 ! blood coagulation GO:0007596 146 78 1,000 0,11979159 0,159855 GO:0050817|coagulation, ! response to steroid hormone stimulus GO:0048545 137 78 1,000 0,11979159 0,15976639 ! protein oligomerization GO:0051259 139 78 1,000 0,11979159 0,15967788 ! positive regulation of protein complex assembly GO:0031334 32 17 0,000 0,12222067 0,16282554 ! negative regulation of hormone secretion GO:0046888 25 17 0,000 0,12222067 0,16273543 ! 2'-deoxyribonucleotide metabolic process GO:0009394 25 17 0,000 0,12222067 0,16264542 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 24 17 0,000 0,12222067 0,16255552 ! gene silencing by RNA GO:0031047 36 17 0,000 0,12222067 0,16246571 ! positive regulation of receptor-mediated endocytosis GO:0048260 21 17 0,000 0,12222067 0,162376 ! glial cell development GO:0021782 27 17 0,000 0,12222067 0,16228638 ! limbic system development GO:0021761 36 17 0,000 0,12222067 0,16219687 ! regulation of muscle cell differentiation GO:0051147 33 17 0,000 0,12222067 0,16210746 ! adult walking behavior GO:0007628 33 17 0,000 0,12222067 0,16201814 ! negative regulation of peptidase activity GO:0010466 27 17 0,000 0,12222067 0,16192892 ! heart looping GO:0001947 30 17 0,000 0,12222067 0,16183981 ! negative regulation of gene expression, epigenetic GO:0045814 35 17 0,000 0,12222067 0,16175079 ! myoblast differentiation GO:0045445 45 17 0,000 0,12222067 0,16166186 ! cell differentiation in spinal cord GO:0021515 30 17 0,000 0,12222067 0,16157304 ! regulation of survival gene product expression GO:0045884 33 17 0,000 0,12222067 0,16148431 ! regulation of striated muscle contraction GO:0006942 21 17 0,000 0,12222067 0,16139568 ! glycine metabolic process GO:0006544 28 17 0,000 0,12222067 0,16130715 ! pyrimidine ribonucleoside metabolic process GO:0046131 21 17 0,000 0,12222067 0,16121871 ! NAD metabolic process GO:0019674 29 17 0,000 0,12222067 0,16113037 ! membrane budding GO:0006900 37 17 0,000 0,12222067 0,16104213 ! DNA integration GO:0015074 29 17 0,000 0,12222067 0,16095398 ! nucleobase metabolic process GO:0009112 37 17 0,000 0,12222067 0,16086593 ! ventricular cardiac muscle morphogenesis GO:0055010 27 17 0,000 0,12222067 0,16077798 ! DNA unwinding during replication GO:0006268 27 17 0,000 0,12222067 0,16069012 ! genitalia development GO:0048806 30 17 0,000 0,12222067 0,16060236 ! neural crest cell migration GO:0001755 37 17 0,000 0,12222067 0,1605147 ! folic acid and derivative metabolic process GO:0006760 33 17 0,000 0,12222067 0,16042713 ! steroid catabolic process GO:0006706 31 17 0,000 0,12222067 0,16033966 ! activation of NF-kappaB-inducing kinase activity GO:0007250 26 17 0,000 0,12222067 0,16025228 ! branched chain family amino acid metabolic process GO:0009081 33 17 0,000 0,12222067 0,16016499 ! gas transport GO:0015669 25 17 0,000 0,12222067 0,1600778 ! organic cation transport GO:0015695 31 17 0,000 0,12222067 0,15999071 ! aromatic compound biosynthetic process GO:0019438 24 17 0,000 0,12222067 0,15990371 ! RNA 3'-end processing GO:0031123 34 17 0,000 0,12222067 0,15981681 ! microspike assembly GO:0030035 36 17 0,000 0,12222067 0,15973 ! regulation of ubiquitin-protein ligase activity GO:0051438 133 79 1,000 0,12231266 0,15976344 ! regulation of adenylate cyclase activity GO:0045761 156 80 1,000 0,12484667 0,16298485 ! response to metal ion GO:0010038 140 80 1,000 0,12484667 0,16289647 ! muscle cell differentiation GO:0042692 159 80 1,000 0,12484667 0,16280818 ! intracellular protein transmembrane transport GO:0065002 153 81 1,000 0,12739327 0,16603912 ! regulation of neuron differentiation GO:0045664 167 81 1,000 0,12739327 0,16594922 ! oligosaccharide metabolic process GO:0009311 34 18 0,000 0,12892795 0,1678575 ! neuron maturation GO:0042551 42 18 0,000 0,12892795 0,16776671 ! positive regulation of anti-apoptosis GO:0045768 39 18 0,000 0,12892795 0,16767603 ! regulation of lipid biosynthetic process GO:0046890 25 18 0,000 0,12892795 0,16758544 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 33 18 0,000 0,12892795 0,16749495 ! protein amino acid ADP-ribosylation GO:0006471 33 18 0,000 0,12892795 0,16740456 ! aminoglycan catabolic process GO:0006026 22 18 0,000 0,12892795 0,16731427 ! memory GO:0007613 31 18 0,000 0,12892795 0,16722407 ! negative regulation of ion transport GO:0043271 24 18 0,000 0,12892795 0,16713397 ! patterning of blood vessels GO:0001569 39 18 0,000 0,12892795 0,16704397 ! cellular response to hydrogen peroxide GO:0070301 23 18 0,000 0,12892795 0,16695407 GO:0042744|hydrogen peroxide catabolic process, ! centrosome cycle GO:0007098 25 18 0,000 0,12892795 0,16686426 ! positive regulation of proteolysis GO:0045862 31 18 0,000 0,12892795 0,16677454 ! glutamine metabolic process GO:0006541 29 18 0,000 0,12892795 0,16668493 ! response to fungus GO:0009620 21 18 0,000 0,12892795 0,16659541 ! positive regulation of alpha-beta T cell differentiation GO:0046638 28 18 0,000 0,12892795 0,16650599 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 26 18 0,000 0,12892795 0,16641666 ! regulation of steroid metabolic process GO:0019218 30 18 0,000 0,12892795 0,16632743 ! long-chain fatty acid transport GO:0015909 31 18 0,000 0,12892795 0,16623829 ! peptide biosynthetic process GO:0043043 24 18 0,000 0,12892795 0,16614925 ! vitamin transport GO:0051180 27 18 0,000 0,12892795 0,16606031 ! porphyrin biosynthetic process GO:0006779 33 18 0,000 0,12892795 0,16597146 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 32 18 0,000 0,12892795 0,1658827 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 32 18 0,000 0,12892795 0,16579404 ! regulation of generation of precursor metabolites and energy GO:0043467 38 18 0,000 0,12892795 0,16570548 ! aromatic compound catabolic process GO:0019439 27 18 0,000 0,12892795 0,16561701 ! nerve development GO:0021675 28 18 0,000 0,12892795 0,16552863 ! positive regulation of synaptic transmission GO:0050806 28 18 0,000 0,12892795 0,16544035 ! regulation of cAMP biosynthetic process GO:0030817 161 82 1,000 0,12995214 0,1666657 ! regulation of cyclase activity GO:0031279 159 82 1,000 0,12995214 0,1665769 ! cellular response to hormone stimulus GO:0032870 167 82 1,000 0,12995214 0,16648821 ! regulation of lyase activity GO:0051339 160 83 1,000 0,13252293 0,16969142 ! regulation of cAMP metabolic process GO:0030814 168 84 1,000 0,13510532 0,17290607 ! hemostasis GO:0007599 158 84 1,000 0,13510532 0,17281414 ! regulation of ligase activity GO:0051340 142 84 1,000 0,13510532 0,17272232 ! protein secretion GO:0009306 39 19 0,000 0,13558421 0,17324248 ! positive regulation of translation GO:0045727 30 19 0,000 0,13558421 0,17315053 ! negative regulation of defense response GO:0031348 25 19 0,000 0,13558421 0,17305867 ! positive regulation of angiogenesis GO:0045766 44 19 0,000 0,13558421 0,17296691 ! positive regulation of hormone secretion GO:0046887 32 19 0,000 0,13558421 0,17287525 ! skin development GO:0043588 36 19 0,000 0,13558421 0,17278369 ! regulation of neuronal synaptic plasticity GO:0048168 41 19 0,000 0,13558421 0,17269222 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,13558421 0,17260085 ! regulation of postsynaptic membrane potential GO:0060078 32 19 0,000 0,13558421 0,17250957 ! negative regulation of epithelial cell proliferation GO:0050680 46 19 0,000 0,13558421 0,17241839 ! cerebral cortex development GO:0021987 36 19 0,000 0,13558421 0,17232731 ! cellular response to unfolded protein GO:0034620 33 19 0,000 0,13558421 0,17223632 GO:0030968|endoplasmic reticulum unfolded protein response, ! heme metabolic process GO:0042168 36 19 0,000 0,13558421 0,17214543 ! actin filament bundle formation GO:0051017 42 19 0,000 0,13558421 0,17205464 ! response to lipopolysaccharide GO:0032496 30 19 0,000 0,13558421 0,17196394 ! peptide cross-linking GO:0018149 37 19 0,000 0,13558421 0,17187334 ! protein export from nucleus GO:0006611 36 19 0,000 0,13558421 0,17178283 ! heart process GO:0003015 30 19 0,000 0,13558421 0,17169242 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 37 19 0,000 0,13558421 0,1716021 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 36 19 0,000 0,13558421 0,17151188 ! positive regulation of myeloid cell differentiation GO:0045639 59 19 0,000 0,13558421 0,17142175 ! positive regulation of transmission of nerve impulse GO:0051971 29 19 0,000 0,13558421 0,17133172 ! purine nucleotide catabolic process GO:0006195 29 19 0,000 0,13558421 0,17124178 ! proximal/distal pattern formation GO:0009954 32 19 0,000 0,13558421 0,17115194 ! estrogen receptor signaling pathway GO:0030520 38 19 0,000 0,13558421 0,17106219 ! somatic recombination of immunoglobulin gene segments GO:0016447 47 19 0,000 0,13558421 0,17097254 ! embryonic organ morphogenesis GO:0048562 26 19 0,000 0,13558421 0,17088297 ! cilium assembly GO:0042384 37 19 0,000 0,13558421 0,17079351 ! peptide hormone secretion GO:0030072 31 19 0,000 0,13558421 0,17070413 ! response to inorganic substance GO:0010035 153 86 1,000 0,1403036 0,17655359 ! protein import into nucleus, docking GO:0000059 41 20 0,000 0,14218981 0,17883361 ! positive regulation of ossification GO:0045778 47 20 0,000 0,14218981 0,17874017 ! pteridine and derivative metabolic process GO:0042558 29 20 0,000 0,14218981 0,17864684 ! protein amino acid deacetylation GO:0006476 29 20 0,000 0,14218981 0,1785536 ! transcription from RNA polymerase III promoter GO:0006383 41 20 0,000 0,14218981 0,17846046 ! regulation of carbohydrate metabolic process GO:0006109 38 20 0,000 0,14218981 0,17836741 GO:0010675|regulation of cellular carbohydrate metabolic process, ! gamma-aminobutyric acid signaling pathway GO:0007214 26 20 0,000 0,14218981 0,17827446 ! retinoid metabolic process GO:0001523 32 20 0,000 0,14218981 0,17818161 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 35 20 0,000 0,14218981 0,17808886 ! photoreceptor cell maintenance GO:0045494 34 20 0,000 0,14218981 0,1779962 ! response to carbohydrate stimulus GO:0009743 29 20 0,000 0,14218981 0,17790364 ! DNA duplex unwinding GO:0032508 31 20 0,000 0,14218981 0,17781117 GO:0032392|DNA geometric change, ! actin polymerization or depolymerization GO:0008154 48 20 0,000 0,14218981 0,1777188 ! D-ribose metabolic process GO:0006014 29 20 0,000 0,14218981 0,17762653 ! body fluid secretion GO:0007589 31 20 0,000 0,14218981 0,17753435 ! peptide secretion GO:0002790 35 20 0,000 0,14218981 0,17744227 ! stem cell differentiation GO:0048863 53 20 0,000 0,14218981 0,17735028 ! behavioral interaction between organisms GO:0051705 38 20 0,000 0,14218981 0,17725839 ! regulation of fatty acid metabolic process GO:0019217 38 20 0,000 0,14218981 0,17716659 ! regulation of interleukin-2 production GO:0032663 35 20 0,000 0,14218981 0,17707489 ! sensory perception of pain GO:0019233 30 20 0,000 0,14218981 0,17698329 ! ribosomal small subunit biogenesis GO:0042274 24 20 0,000 0,14218981 0,17689178 ! diencephalon development GO:0021536 34 20 0,000 0,14218981 0,17680036 ! protein localization in mitochondrion GO:0070585 32 20 0,000 0,14218981 0,17670904 GO:0006626|protein targeting to mitochondrion, ! detection of chemical stimulus GO:0009593 37 20 0,000 0,14218981 0,17661781 ! positive regulation of neurological system process GO:0031646 32 20 0,000 0,14218981 0,17652667 ! negative regulation of myeloid cell differentiation GO:0045638 29 20 0,000 0,14218981 0,17643563 ! leukotriene biosynthetic process GO:0019370 37 20 0,000 0,14218981 0,17634469 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 42 20 0,000 0,14218981 0,17625384 ! pyrimidine nucleotide biosynthetic process GO:0006221 28 20 0,000 0,14218981 0,17616308 ! inner ear receptor cell differentiation GO:0060113 37 20 0,000 0,14218981 0,17607241 ! binding of sperm to zona pellucida GO:0007339 20 20 0,000 0,14218981 0,17598184 ! negative regulation of translation GO:0017148 29 20 0,000 0,14218981 0,17589136 ! regulation of nucleotide biosynthetic process GO:0030808 170 87 1,000 0,14291885 0,17670234 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! reciprocal meiotic recombination GO:0007131 39 21 0,000 0,14874516 0,18381144 ! phosphatidylinositol metabolic process GO:0046488 36 21 0,000 0,14874516 0,18371708 ! hormone secretion GO:0046879 38 21 0,000 0,14874516 0,18362281 ! glycerol metabolic process GO:0006071 34 21 0,000 0,14874516 0,18352865 ! intra-Golgi vesicle-mediated transport GO:0006891 40 21 0,000 0,14874516 0,18343458 ! regulation of neurotransmitter transport GO:0051588 42 21 0,000 0,14874516 0,18334061 ! cellular macromolecular complex disassembly GO:0034623 43 21 0,000 0,14874516 0,18324673 ! neurotransmitter metabolic process GO:0042133 34 21 0,000 0,14874516 0,18315295 ! regulation of alpha-beta T cell differentiation GO:0046637 37 21 0,000 0,14874516 0,18305927 ! regulation of myeloid leukocyte differentiation GO:0002761 39 21 0,000 0,14874516 0,18296568 ! cytolysis GO:0019835 24 21 0,000 0,14874516 0,18287218 ! vasodilation GO:0042311 39 21 0,000 0,14874516 0,18277879 ! cholesterol biosynthetic process GO:0006695 37 21 0,000 0,14874516 0,18268548 ! regulation of Rho GTPase activity GO:0032319 43 21 0,000 0,14874516 0,18259228 ! DNA modification GO:0006304 34 21 0,000 0,14874516 0,18249917 ! collagen fibril organization GO:0030199 59 21 0,000 0,14874516 0,18240615 ! detection of biotic stimulus GO:0009595 29 21 0,000 0,14874516 0,18231323 ! sphingolipid biosynthetic process GO:0030148 40 21 0,000 0,14874516 0,1822204 ! vitamin A metabolic process GO:0006776 33 21 0,000 0,14874516 0,18212767 ! positive regulation of osteoblast differentiation GO:0045669 49 21 0,000 0,14874516 0,18203503 ! terpenoid metabolic process GO:0006721 37 21 0,000 0,14874516 0,18194248 ! collagen catabolic process GO:0030574 28 21 0,000 0,14874516 0,18185003 ! sperm-egg recognition GO:0035036 21 21 0,000 0,14874516 0,18175768 ! regulation of cyclic nucleotide metabolic process GO:0030799 179 90 1,000 0,1508253 0,18420593 ! response to protein stimulus GO:0051789 149 91 1,000 0,15348001 0,18735307 ! positive regulation of protein catabolic process GO:0045732 38 22 0,000 0,15525063 0,18941837 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 27 22 0,000 0,15525063 0,18932236 ! sulfur amino acid metabolic process GO:0000096 41 22 0,000 0,15525063 0,18922646 ! cellular aldehyde metabolic process GO:0006081 34 22 0,000 0,15525063 0,18913065 ! positive regulation of bone remodeling GO:0046852 51 22 0,000 0,15525063 0,18903493 GO:0034105|positive regulation of tissue remodeling, ! regulation of receptor-mediated endocytosis GO:0048259 28 22 0,000 0,15525063 0,18893931 ! glutamate signaling pathway GO:0007215 41 22 0,000 0,15525063 0,18884379 ! keratinization GO:0031424 28 22 0,000 0,15525063 0,18874837 ! calcium-independent cell-cell adhesion GO:0016338 30 22 0,000 0,15525063 0,18865304 ! mechanoreceptor differentiation GO:0042490 40 22 0,000 0,15525063 0,18855781 ! sensory perception of taste GO:0050909 28 22 0,000 0,15525063 0,18846268 ! deoxyribonucleotide metabolic process GO:0009262 32 22 0,000 0,15525063 0,18836764 ! vacuolar transport GO:0007034 36 22 0,000 0,15525063 0,18827269 ! lysosome organization GO:0007040 41 22 0,000 0,15525063 0,18817785 ! central nervous system neuron development GO:0021954 46 22 0,000 0,15525063 0,18808309 ! cellular response to reactive oxygen species GO:0034614 31 22 0,000 0,15525063 0,18798844 ! positive regulation of cytoskeleton organization GO:0051495 48 22 0,000 0,15525063 0,18789388 ! fucose metabolic process GO:0006004 39 22 0,000 0,15525063 0,18779941 ! cardiac muscle tissue morphogenesis GO:0055008 33 22 0,000 0,15525063 0,18770504 GO:0060415|muscle tissue morphogenesis, ! regulation of cytokine secretion GO:0050707 37 22 0,000 0,15525063 0,18761076 ! sarcomere organization GO:0045214 30 22 0,000 0,15525063 0,18751658 ! aromatic amino acid family metabolic process GO:0009072 32 22 0,000 0,15525063 0,18742249 ! somatic diversification of immunoglobulins GO:0016445 50 22 0,000 0,15525063 0,1873285 ! regulation of mitotic metaphase/anaphase transition GO:0030071 42 22 0,000 0,15525063 0,1872346 ! regulation of nucleotide metabolic process GO:0006140 182 93 1,000 0,15881648 0,1914391 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 33 23 0,000 0,1617066 0,19482528 ! regulation of anti-apoptosis GO:0045767 53 23 0,000 0,1617066 0,19472777 ! gluconeogenesis GO:0006094 33 23 0,000 0,1617066 0,19463036 ! viral genome replication GO:0019079 41 23 0,000 0,1617066 0,19453304 ! membrane lipid biosynthetic process GO:0046467 42 23 0,000 0,1617066 0,19443582 ! nucleotide-excision repair, DNA damage removal GO:0000718 33 23 0,000 0,1617066 0,1943387 ! protein amino acid O-linked glycosylation GO:0006493 42 23 0,000 0,1617066 0,19424168 ! glucosamine metabolic process GO:0006041 30 23 0,000 0,1617066 0,19414475 GO:0006044|N-acetylglucosamine metabolic process, ! glycosaminoglycan biosynthetic process GO:0006024 42 23 0,000 0,1617066 0,19404792 ! visual behavior GO:0007632 42 23 0,000 0,1617066 0,19395119 ! peroxisome organization GO:0007031 37 23 0,000 0,1617066 0,19385455 ! polysaccharide catabolic process GO:0000272 27 23 0,000 0,1617066 0,19375801 ! purine ribonucleoside metabolic process GO:0046128 34 23 0,000 0,1617066 0,19366156 GO:0042278|purine nucleoside metabolic process, ! vesicle targeting GO:0006903 43 23 0,000 0,1617066 0,19356522 ! barbed-end actin filament capping GO:0051016 50 23 0,000 0,1617066 0,19346896 GO:0051693|actin filament capping, ! leukotriene metabolic process GO:0006691 42 23 0,000 0,1617066 0,1933728 ! glycosphingolipid metabolic process GO:0006687 41 23 0,000 0,1617066 0,19327674 ! regulation of interleukin-6 production GO:0032675 29 23 0,000 0,1617066 0,19318078 ! synaptic vesicle transport GO:0048489 46 23 0,000 0,1617066 0,1930849 ! fatty acid transport GO:0015908 44 23 0,000 0,1617066 0,19298913 ! regulation of bone mineralization GO:0030500 49 23 0,000 0,1617066 0,19289345 ! nerve-nerve synaptic transmission GO:0007270 49 23 0,000 0,1617066 0,19279786 ! hormone transport GO:0009914 40 23 0,000 0,1617066 0,19270237 ! cell-cell recognition GO:0009988 25 23 0,000 0,1617066 0,19260697 ! negative regulation of cytokine production GO:0001818 40 23 0,000 0,1617066 0,19251167 ! pyrimidine nucleoside metabolic process GO:0006213 29 23 0,000 0,1617066 0,19241646 ! acetyl-CoA catabolic process GO:0046356 36 23 0,000 0,1617066 0,19232135 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 34 23 0,000 0,1617066 0,19222633 ! mRNA transport GO:0051028 169 96 1,000 0,16688448 0,19828349 ! positive regulation of immune response GO:0050778 156 96 1,000 0,16688448 0,19818562 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 54 24 0,000 0,16811344 0,19954659 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 52 24 0,000 0,16811344 0,1994482 ! post-Golgi vesicle-mediated transport GO:0006892 58 24 0,000 0,16811344 0,1993499 ! spinal cord development GO:0021510 47 24 0,000 0,16811344 0,1992517 ! vacuole organization GO:0007033 43 24 0,000 0,16811344 0,19915359 ! digestive system process GO:0022600 39 24 0,000 0,16811344 0,19905558 ! central nervous system neuron differentiation GO:0021953 50 24 0,000 0,16811344 0,19895767 ! regulation of tumor necrosis factor production GO:0032680 34 24 0,000 0,16811344 0,19885985 ! membrane depolarization GO:0051899 39 24 0,000 0,16811344 0,19876213 ! pallium development GO:0021543 49 24 0,000 0,16811344 0,19866451 ! pentose metabolic process GO:0019321 35 24 0,000 0,16811344 0,19856698 ! cellular alkene metabolic process GO:0043449 43 24 0,000 0,16811344 0,19846955 ! glutamine family amino acid catabolic process GO:0009065 39 24 0,000 0,16811344 0,19837221 ! aspartate family amino acid metabolic process GO:0009066 42 24 0,000 0,16811344 0,19827497 ! porphyrin metabolic process GO:0006778 46 24 0,000 0,16811344 0,19817783 GO:0033013|tetrapyrrole metabolic process, ! alditol metabolic process GO:0019400 38 24 0,000 0,16811344 0,19808078 ! regulation of multi-organism process GO:0043900 36 24 0,000 0,16811344 0,19798382 ! regulation of amine transport GO:0051952 40 24 0,000 0,16811344 0,19788696 ! hormone metabolic process GO:0042445 157 97 1,000 0,16958957 0,1995269 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 32 25 0,000 0,17447153 0,20517033 ! aminoglycan biosynthetic process GO:0006023 44 25 0,000 0,17447153 0,2050701 ! dicarboxylic acid metabolic process GO:0043648 42 25 0,000 0,17447153 0,20496997 ! phototransduction GO:0007602 33 25 0,000 0,17447153 0,20486994 ! protein amino acid alkylation GO:0008213 53 25 0,000 0,17447153 0,20477 GO:0006479|protein amino acid methylation, ! sperm motility GO:0030317 31 25 0,000 0,17447153 0,20467016 ! osteoblast differentiation GO:0001649 60 25 0,000 0,17447153 0,20457042 ! neural crest cell development GO:0014032 54 25 0,000 0,17447153 0,20447077 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 39 25 0,000 0,17447153 0,20437123 ! regulation of insulin secretion GO:0050796 37 25 0,000 0,17447153 0,20427178 ! hydrogen peroxide metabolic process GO:0042743 33 25 0,000 0,17447153 0,20417242 ! interaction with host GO:0051701 62 25 0,000 0,17447153 0,20407317 ! regulation of biomineral formation GO:0070167 51 25 0,000 0,17447153 0,203974 ! ribonucleoside monophosphate metabolic process GO:0009161 42 25 0,000 0,17447153 0,20387494 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! proteoglycan biosynthetic process GO:0030166 50 25 0,000 0,17447153 0,20377597 ! positive regulation of protein secretion GO:0050714 36 25 0,000 0,17447153 0,2036771 ! neuromuscular process controlling balance GO:0050885 60 25 0,000 0,17447153 0,20357832 ! telomere organization GO:0032200 43 25 0,000 0,17447153 0,20347964 GO:0000723|telomere maintenance, ! liver development GO:0001889 53 25 0,000 0,17447153 0,20338106 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 155 99 1,000 0,17502174 0,20392363 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 30 26 0,000 0,18078123 0,21053226 ! embryonic pattern specification GO:0009880 44 26 0,000 0,18078123 0,2104304 ! negative regulation of actin filament depolymerization GO:0030835 55 26 0,000 0,18078123 0,21032865 ! negative regulation of actin filament polymerization GO:0030837 53 26 0,000 0,18078123 0,21022699 ! initiation of viral infection GO:0019059 57 26 0,000 0,18078123 0,21012543 ! regulation of interferon-gamma production GO:0032649 39 26 0,000 0,18078123 0,21002397 ! pyruvate metabolic process GO:0006090 38 26 0,000 0,18078123 0,20992261 ! acetyl-CoA metabolic process GO:0006084 39 26 0,000 0,18078123 0,20982134 ! cellular polysaccharide biosynthetic process GO:0033692 37 26 0,000 0,18078123 0,20972018 ! macromolecular complex disassembly GO:0032984 53 26 0,000 0,18078123 0,20961911 ! odontogenesis of dentine-containing tooth GO:0042475 48 26 0,000 0,18078123 0,20951813 ! microtubule organizing center organization GO:0031023 39 26 0,000 0,18078123 0,20941726 GO:0051297|centrosome organization, ! regulation of cellular ketone metabolic process GO:0010565 44 26 0,000 0,18078123 0,20931648 ! cellular response to oxidative stress GO:0034599 39 26 0,000 0,18078123 0,2092158 ! response to estradiol stimulus GO:0032355 40 26 0,000 0,18078123 0,20911521 ! regulation of response to biotic stimulus GO:0002831 44 26 0,000 0,18078123 0,20901473 ! positive regulation of nuclear division GO:0051785 40 26 0,000 0,18078123 0,20891433 GO:0045840|positive regulation of mitosis, ! group transfer coenzyme metabolic process GO:0006752 47 26 0,000 0,18078123 0,20881404 ! regulation of osteoblast differentiation GO:0045667 65 26 0,000 0,18078123 0,20871384 ! somatic diversification of immune receptors GO:0002200 56 26 0,000 0,18078123 0,20861374 ! water-soluble vitamin biosynthetic process GO:0042364 35 26 0,000 0,18078123 0,20851373 ! neuron fate commitment GO:0048663 48 27 0,000 0,18704292 0,21563261 ! iron ion transport GO:0006826 59 27 0,000 0,18704292 0,21552934 ! spliceosomal snRNP biogenesis GO:0000387 36 27 0,000 0,18704292 0,21542616 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 55 27 0,000 0,18704292 0,21532309 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! superoxide metabolic process GO:0006801 38 27 0,000 0,18704292 0,21522011 ! fat cell differentiation GO:0045444 50 27 0,000 0,18704292 0,21511723 ! positive regulation of innate immune response GO:0045089 43 27 0,000 0,18704292 0,21501445 ! multicellular organismal catabolic process GO:0044243 36 27 0,000 0,18704292 0,21491177 ! autophagy GO:0006914 41 27 0,000 0,18704292 0,21480919 ! glycolipid metabolic process GO:0006664 47 27 0,000 0,18704292 0,2147067 ! fat-soluble vitamin metabolic process GO:0006775 40 27 0,000 0,18704292 0,21460432 ! negative regulation of neuron differentiation GO:0045665 42 27 0,000 0,18704292 0,21450203 ! negative regulation of protein polymerization GO:0032272 55 27 0,000 0,18704292 0,21439983 ! regulation of actin filament depolymerization GO:0030834 58 28 0,000 0,19325694 0,22141724 ! circadian rhythm GO:0007623 50 28 0,000 0,19325694 0,22131185 ! detection of light stimulus involved in sensory perception GO:0050962 36 28 0,000 0,19325694 0,22120657 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 45 28 0,000 0,19325694 0,22110138 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 53 28 0,000 0,19325694 0,2209963 ! vitamin biosynthetic process GO:0009110 39 28 0,000 0,19325694 0,22089131 ! synaptogenesis GO:0007416 42 28 0,000 0,19325694 0,22078642 ! ethanolamine and derivative metabolic process GO:0042439 46 28 0,000 0,19325694 0,22068164 ! translational initiation GO:0006413 65 29 0,000 0,19942368 0,22761545 ! negative regulation of protein complex assembly GO:0031333 59 29 0,000 0,19942368 0,22750753 ! icosanoid biosynthetic process GO:0046456 54 29 0,000 0,19942368 0,2273997 ! cellular iron ion homeostasis GO:0006879 51 29 0,000 0,19942368 0,22729198 ! amino sugar metabolic process GO:0006040 38 29 0,000 0,19942368 0,22718436 ! catechol metabolic process GO:0009712 54 29 0,000 0,19942368 0,22707684 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! complement activation, classical pathway GO:0006958 48 29 0,000 0,19942368 0,22696943 ! respiratory gaseous exchange GO:0007585 57 29 0,000 0,19942368 0,22686211 ! regulation of peptide secretion GO:0002791 47 29 0,000 0,19942368 0,2267549 ! cell fate determination GO:0001709 60 29 0,000 0,19942368 0,22664779 ! sterol biosynthetic process GO:0016126 52 29 0,000 0,19942368 0,22654078 ! detection of light stimulus GO:0009583 38 29 0,000 0,19942368 0,22643387 ! phenol metabolic process GO:0018958 55 30 0,000 0,20554348 0,23327246 ! zinc ion transport GO:0006829 45 30 0,000 0,20554348 0,23316248 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 47 30 0,000 0,20554348 0,2330526 ! regulation of innate immune response GO:0045088 51 30 0,000 0,20554348 0,23294282 ! acute-phase response GO:0006953 49 30 0,000 0,20554348 0,23283315 ! myofibril assembly GO:0030239 47 30 0,000 0,20554348 0,23272358 GO:0055002|striated muscle cell development, ! determination of left/right symmetry GO:0007368 47 30 0,000 0,20554348 0,23261412 ! phospholipid transport GO:0015914 51 30 0,000 0,20554348 0,23250475 ! nicotinamide metabolic process GO:0006769 52 30 0,000 0,20554348 0,23239549 GO:0046496|nicotinamide nucleotide metabolic process, ! cofactor catabolic process GO:0051187 51 30 0,000 0,20554348 0,23228634 ! neurotransmitter secretion GO:0007269 48 30 0,000 0,20554348 0,23217728 ! eye morphogenesis GO:0048592 60 30 0,000 0,20554348 0,23206833 ! alkaloid metabolic process GO:0009820 53 31 0,000 0,2116167 0,23881322 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 46 31 0,000 0,2116167 0,23870126 ! mRNA export from nucleus GO:0006406 48 31 0,000 0,2116167 0,2385894 ! determination of bilateral symmetry GO:0009855 49 31 0,000 0,2116167 0,23847765 GO:0009799|determination of symmetry, ! collagen metabolic process GO:0032963 45 31 0,000 0,2116167 0,238366 ! inner ear morphogenesis GO:0042472 47 31 0,000 0,2116167 0,23825446 ! cholesterol homeostasis GO:0042632 53 31 0,000 0,2116167 0,23814302 GO:0055092|sterol homeostasis, ! GPI anchor biosynthetic process GO:0006506 53 31 0,000 0,2116167 0,23803169 ! cellular carbohydrate biosynthetic process GO:0034637 42 31 0,000 0,2116167 0,23792046 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 51 31 0,000 0,2116167 0,23780933 ! triglyceride metabolic process GO:0006641 43 31 0,000 0,2116167 0,23769831 ! iron ion homeostasis GO:0055072 54 31 0,000 0,2116167 0,23758739 ! erythrocyte differentiation GO:0030218 55 31 0,000 0,2116167 0,23747658 ! mesoderm formation GO:0001707 69 31 0,000 0,2116167 0,23736587 ! natural killer cell activation GO:0030101 45 31 0,000 0,2116167 0,23725526 ! serine family amino acid metabolic process GO:0009069 49 31 0,000 0,2116167 0,23714475 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 47 32 0,000 0,2176437 0,24378526 ! proteoglycan metabolic process GO:0006029 63 32 0,000 0,2176437 0,24367182 ! negative regulation of response to external stimulus GO:0032102 47 32 0,000 0,2176437 0,24355848 ! cholesterol transport GO:0030301 56 32 0,000 0,2176437 0,24344525 ! GPI anchor metabolic process GO:0006505 56 32 0,000 0,2176437 0,24333212 ! spliceosome assembly GO:0000245 67 32 0,000 0,2176437 0,2432191 ! pigment biosynthetic process GO:0046148 66 32 0,000 0,2176437 0,24310619 ! unsaturated fatty acid biosynthetic process GO:0006636 59 32 0,000 0,2176437 0,24299338 ! response to mechanical stimulus GO:0009612 57 32 0,000 0,2176437 0,24288067 ! regulation of axonogenesis GO:0050770 75 32 0,000 0,2176437 0,24276807 ! muscle cell development GO:0055001 49 32 0,000 0,2176437 0,24265558 ! nuclear-transcribed mRNA catabolic process GO:0000956 51 32 0,000 0,2176437 0,24254318 ! regulation of ARF GTPase activity GO:0032312 65 32 0,000 0,2176437 0,24243089 ! hexose biosynthetic process GO:0019319 48 32 0,000 0,2176437 0,24231871 ! BMP signaling pathway GO:0030509 64 32 0,000 0,2176437 0,24220663 ! regulation of calcium ion transport GO:0051924 53 32 0,000 0,2176437 0,24209465 ! positive regulation of catabolic process GO:0009896 64 32 0,000 0,2176437 0,24198278 ! gene silencing GO:0016458 65 32 0,000 0,2176437 0,24187101 ! protein targeting to membrane GO:0006612 68 33 0,000 0,22362481 0,24840319 ! positive regulation of neurogenesis GO:0050769 67 33 0,000 0,22362481 0,24828856 ! ceramide metabolic process GO:0006672 64 33 0,000 0,22362481 0,24817403 ! formation of primary germ layer GO:0001704 72 33 0,000 0,22362481 0,24805961 ! cell fate specification GO:0001708 52 33 0,000 0,22362481 0,2479453 ! sterol transport GO:0015918 57 33 0,000 0,22362481 0,24783109 ! pyridine nucleotide metabolic process GO:0019362 55 33 0,000 0,22362481 0,24771699 ! adult locomotory behavior GO:0008344 59 33 0,000 0,22362481 0,24760299 ! establishment of vesicle localization GO:0051650 61 33 0,000 0,22362481 0,2474891 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 48 34 0,000 0,2295604 0,2539413 ! glial cell differentiation GO:0010001 63 34 0,000 0,2295604 0,2538246 ! xenobiotic metabolic process GO:0006805 51 34 0,000 0,2295604 0,25370801 ! positive regulation of endocytosis GO:0045807 50 34 0,000 0,2295604 0,25359152 ! antigen processing and presentation of peptide antigen GO:0048002 62 34 0,000 0,2295604 0,25347514 ! multicellular organismal macromolecule metabolic process GO:0044259 50 34 0,000 0,2295604 0,25335887 ! mesoderm morphogenesis GO:0048332 76 34 0,000 0,2295604 0,2532427 ! mismatch repair GO:0006298 46 34 0,000 0,2295604 0,25312664 ! spermatid development GO:0007286 63 34 0,000 0,2295604 0,25301069 ! biogenic amine biosynthetic process GO:0042401 62 34 0,000 0,2295604 0,25289484 ! pyrimidine nucleotide metabolic process GO:0006220 52 34 0,000 0,2295604 0,2527791 ! placenta development GO:0001890 53 34 0,000 0,2295604 0,25266346 ! symbiosis, encompassing mutualism through parasitism GO:0044403 73 34 0,000 0,2295604 0,25254793 ! negative regulation of secretion GO:0051048 63 35 0,000 0,23545081 0,2589098 ! regulation of synaptic plasticity GO:0048167 64 35 0,000 0,23545081 0,25879153 ! odontogenesis GO:0042476 66 35 0,000 0,23545081 0,25867336 ! neutral lipid metabolic process GO:0006638 50 35 0,000 0,23545081 0,25855529 GO:0006639|acylglycerol metabolic process, ! telencephalon development GO:0021537 68 35 0,000 0,23545081 0,25843734 ! cytokine production GO:0001816 59 35 0,000 0,23545081 0,25831949 ! vesicle localization GO:0051648 64 35 0,000 0,23545081 0,25820176 ! positive regulation of JAK-STAT cascade GO:0046427 50 36 0,000 0,24129638 0,26449161 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 49 36 0,000 0,24129638 0,26437117 ! sphingoid metabolic process GO:0046519 70 36 0,000 0,24129638 0,26425083 ! regulation of proteolysis GO:0030162 72 36 0,000 0,24129638 0,26413061 ! aerobic respiration GO:0009060 55 36 0,000 0,24129638 0,2640105 ! embryonic organ development GO:0048568 57 36 0,000 0,24129638 0,26389049 ! monosaccharide biosynthetic process GO:0046364 52 36 0,000 0,24129638 0,2637706 ! RNA export from nucleus GO:0006405 56 37 0,000 0,24709744 0,2699893 ! cellular component assembly involved in morphogenesis GO:0010927 59 37 0,000 0,24709744 0,26986675 ! actomyosin structure organization GO:0031032 62 37 0,000 0,24709744 0,2697443 ! organic anion transport GO:0015711 68 37 0,000 0,24709744 0,26962197 ! glycerol ether metabolic process GO:0006662 53 37 0,000 0,24709744 0,26949975 ! energy coupled proton transport, down electrochemical gradient GO:0015985 62 37 0,000 0,24709744 0,26937764 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 66 37 0,000 0,24709744 0,26925564 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 58 38 0,000 0,25285434 0,27540405 GO:0006956|complement activation, ! phosphoinositide biosynthetic process GO:0046489 67 38 0,000 0,25285434 0,27527943 ! regulation of neuron projection development GO:0010975 91 38 0,000 0,25285434 0,27515493 ! regulation of metal ion transport GO:0010959 63 38 0,000 0,25285434 0,27503054 ! carbohydrate homeostasis GO:0033500 53 38 0,000 0,25285434 0,27490626 GO:0042593|glucose homeostasis, ! lipid homeostasis GO:0055088 67 38 0,000 0,25285434 0,27478209 ! nucleotide catabolic process GO:0009166 61 38 0,000 0,25285434 0,27465804 ! erythrocyte homeostasis GO:0034101 64 38 0,000 0,25285434 0,27453409 ! isoprenoid metabolic process GO:0006720 66 38 0,000 0,25285434 0,27441026 ! regulation of cell morphogenesis involved in differentiation GO:0010769 90 38 0,000 0,25285434 0,27428654 ! mRNA catabolic process GO:0006402 71 39 0,000 0,25856742 0,28035746 ! learning GO:0007612 77 39 0,000 0,25856742 0,28023117 ! ear morphogenesis GO:0042471 60 39 0,000 0,25856742 0,280105 ! organic ether metabolic process GO:0018904 55 39 0,000 0,25856742 0,27997894 ! ion transmembrane transport GO:0034220 66 39 0,000 0,25856742 0,27985299 ! RNA modification GO:0009451 57 39 0,000 0,25856742 0,27972716 ! response to xenobiotic stimulus GO:0009410 57 39 0,000 0,25856742 0,27960144 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 62 40 0,000 0,26423699 0,28560386 ! regulation of hormone secretion GO:0046883 62 40 0,000 0,26423699 0,28547562 ! ER to Golgi vesicle-mediated transport GO:0006888 85 40 0,000 0,26423699 0,28534749 ! feeding behavior GO:0007631 59 40 0,000 0,26423699 0,28521947 ! multicellular organismal metabolic process GO:0044236 57 40 0,000 0,26423699 0,28509157 ! ribonucleoside metabolic process GO:0009119 55 40 0,000 0,26423699 0,28496378 ! protein amino acid N-linked glycosylation GO:0006487 65 41 0,000 0,2698634 0,29090114 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 70 41 0,000 0,2698634 0,29077086 ! cellular amide metabolic process GO:0043603 67 41 0,000 0,2698634 0,29064071 ! gliogenesis GO:0042063 88 41 0,000 0,2698634 0,29051067 ! hormone-mediated signaling GO:0009755 74 41 0,000 0,2698634 0,29038074 ! keratinocyte differentiation GO:0030216 62 41 0,000 0,2698634 0,29025093 ! monocarboxylic acid transport GO:0015718 85 42 0,000 0,27544697 0,29612395 ! alcohol biosynthetic process GO:0046165 59 42 0,000 0,27544697 0,2959917 ! regulation of protein secretion GO:0050708 71 42 0,000 0,27544697 0,29585956 ! regulation of myeloid cell differentiation GO:0045637 98 42 0,000 0,27544697 0,29572753 ! transforming growth factor beta receptor signaling pathway GO:0007179 76 43 0,000 0,28098802 0,30154201 ! receptor-mediated endocytosis GO:0006898 88 43 0,000 0,28098802 0,30140757 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 78 43 0,000 0,28098802 0,30127325 ! glucose transport GO:0015758 65 43 0,000 0,28098802 0,30113906 ! striated muscle cell differentiation GO:0051146 82 43 0,000 0,28098802 0,30100498 ! striated muscle contraction GO:0006941 77 43 0,000 0,28098802 0,30087102 ! phagocytosis GO:0006909 90 43 0,000 0,28098802 0,30073718 ! heterocycle biosynthetic process GO:0018130 69 43 0,000 0,28098802 0,30060346 ! activation of adenylate cyclase activity GO:0007190 91 44 0,000 0,28648688 0,30634997 ! hexose transport GO:0008645 67 44 0,000 0,28648688 0,30621388 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 98 44 0,000 0,28648688 0,3060779 ! biopolymer methylation GO:0043414 84 44 0,000 0,28648688 0,30594205 ! JAK-STAT cascade GO:0007259 71 44 0,000 0,28648688 0,30580632 ! regulation of actin filament polymerization GO:0030833 87 45 0,000 0,29194387 0,31149311 ! glycolysis GO:0006096 65 45 0,000 0,29194387 0,31135503 ! regulation of JAK-STAT cascade GO:0046425 70 45 0,000 0,29194387 0,31121708 ! detection of stimulus involved in sensory perception GO:0050906 66 45 0,000 0,29194387 0,31107925 ! polysaccharide biosynthetic process GO:0000271 70 45 0,000 0,29194387 0,31094155 ! positive regulation of cytokine biosynthetic process GO:0042108 65 45 0,000 0,29194387 0,31080396 ! ATP synthesis coupled electron transport GO:0042773 64 45 0,000 0,29194387 0,3106665 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! icosanoid metabolic process GO:0006690 80 45 0,000 0,29194387 0,31052916 ! oxidoreduction coenzyme metabolic process GO:0006733 72 45 0,000 0,29194387 0,31039194 ! positive regulation of adenylate cyclase activity GO:0045762 101 46 0,000 0,29735931 0,31600993 ! epidermal cell differentiation GO:0009913 68 46 0,000 0,29735931 0,31587041 ! response to calcium ion GO:0051592 81 47 0,000 0,3027335 0,32143724 ! positive regulation of cyclase activity GO:0031281 103 47 0,000 0,3027335 0,32129546 ! methylation GO:0032259 90 47 0,000 0,3027335 0,32115379 ! protein homooligomerization GO:0051260 76 47 0,000 0,3027335 0,32101225 ! regulation of ARF protein signal transduction GO:0032012 102 48 0,000 0,30806676 0,32652363 ! positive regulation of lyase activity GO:0051349 104 48 0,000 0,30806676 0,32637985 ! protein amino acid lipidation GO:0006497 95 49 0,000 0,31335941 0,331841 ! regulation of ion transport GO:0043269 77 49 0,000 0,31335941 0,331695 ! unsaturated fatty acid metabolic process GO:0033559 86 49 0,000 0,31335941 0,33154914 ! endocrine system development GO:0035270 104 49 0,000 0,31335941 0,3314034 ! immunoglobulin mediated immune response GO:0016064 83 49 0,000 0,31335941 0,3312578 GO:0019724|B cell mediated immunity, ! ribonucleoprotein complex assembly GO:0022618 95 49 0,000 0,31335941 0,33111232 ! detection of abiotic stimulus GO:0009582 74 49 0,000 0,31335941 0,33096696 ! neuromuscular process GO:0050905 99 50 0,000 0,31861175 0,33636677 ! inner ear development GO:0048839 79 50 0,000 0,31861175 0,33621924 ! regulation of gene expression, epigenetic GO:0040029 105 50 0,000 0,31861175 0,33607184 ! positive regulation of cytokine production GO:0001819 86 50 0,000 0,31861175 0,33592457 ! viral infectious cycle GO:0019058 99 51 0,000 0,32382409 0,34127059 ! cellular amino acid biosynthetic process GO:0008652 75 51 0,000 0,32382409 0,34112117 ! excretion GO:0007588 83 51 0,000 0,32382409 0,34097188 ! RNA elongation from RNA polymerase II promoter GO:0006368 72 51 0,000 0,32382409 0,34082273 ! chromatin remodeling GO:0006338 109 51 0,000 0,32382409 0,3406737 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 70 51 0,000 0,32382409 0,3405248 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 76 51 0,000 0,32382409 0,34037604 ! amino acid activation GO:0043038 92 52 0,000 0,32899672 0,34566206 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 76 53 0,000 0,33412996 0,35090209 ! RNA catabolic process GO:0006401 93 53 0,000 0,33412996 0,35074899 ! regulation of translational initiation GO:0006446 82 53 0,000 0,33412996 0,35059602 ! lipoprotein biosynthetic process GO:0042158 101 53 0,000 0,33412996 0,35044319 ! regulation of actin polymerization or depolymerization GO:0008064 98 53 0,000 0,33412996 0,35029049 ! cell maturation GO:0048469 100 53 0,000 0,33412996 0,35013793 ! regulation of protein polymerization GO:0032271 103 53 0,000 0,33412996 0,34998549 ! generation of a signal involved in cell-cell signaling GO:0003001 95 54 0,000 0,3392241 0,35516674 ! cell recognition GO:0008037 85 54 0,000 0,3392241 0,35501225 ! heterocycle catabolic process GO:0046700 85 54 0,000 0,3392241 0,3548579 ! glutamine family amino acid metabolic process GO:0009064 78 54 0,000 0,3392241 0,35470368 ! cellular amino acid derivative biosynthetic process GO:0042398 90 54 0,000 0,3392241 0,3545496 ! chloride transport GO:0006821 90 55 0,000 0,34427943 0,35967707 ! glucose catabolic process GO:0006007 82 55 0,000 0,34427943 0,35952096 ! sulfur compound biosynthetic process GO:0044272 93 55 0,000 0,34427943 0,35936499 ! gastrulation GO:0007369 112 55 0,000 0,34427943 0,35920915 ! heart morphogenesis GO:0003007 97 55 0,000 0,34427943 0,35905345 ! RNA elongation GO:0006354 79 55 0,000 0,34427943 0,35889788 ! regulation of actin filament length GO:0030832 105 56 0,000 0,34929625 0,36397002 ! sensory perception of smell GO:0007608 80 56 0,000 0,34929625 0,36381246 ! glycosaminoglycan metabolic process GO:0030203 91 56 0,000 0,34929625 0,36365503 ! proton transport GO:0015992 94 56 0,000 0,34929625 0,36349774 ! positive regulation of organelle organization GO:0010638 100 56 0,000 0,34929625 0,36334059 ! hydrogen transport GO:0006818 97 58 0,000 0,35921553 0,37349722 ! adult behavior GO:0030534 99 58 0,000 0,35921553 0,37333589 ! positive regulation of secretion GO:0051047 95 59 0,000 0,36411857 0,37826826 ! regulation of cellular component size GO:0032535 109 59 0,000 0,36411857 0,378105 ! regulation of Rab protein signal transduction GO:0032483 92 59 0,000 0,36411857 0,37794188 GO:0032313|regulation of Rab GTPase activity, ! regulation of neurotransmitter levels GO:0001505 97 60 0,000 0,36898426 0,38282713 ! nucleoside metabolic process GO:0009116 81 60 0,000 0,36898426 0,38266212 ! camera-type eye development GO:0043010 116 60 0,000 0,36898426 0,38249725 ! glycerophospholipid biosynthetic process GO:0046474 105 61 0,000 0,37381287 0,38733582 ! regulation of protein complex assembly GO:0043254 117 61 0,000 0,37381287 0,38716908 ! tRNA processing GO:0008033 89 61 0,000 0,37381287 0,38700248 ! sphingolipid metabolic process GO:0006665 107 61 0,000 0,37381287 0,38683603 ! viral reproductive process GO:0022415 126 62 0,000 0,37860469 0,39162635 ! water-soluble vitamin metabolic process GO:0006767 95 62 0,000 0,37860469 0,39145805 ! regulation of lipid metabolic process GO:0019216 115 63 0,000 0,38336001 0,39620454 ! detection of external stimulus GO:0009581 91 63 0,000 0,38336001 0,39603442 ! cellular amino acid catabolic process GO:0009063 101 63 0,000 0,38336001 0,39586445 ! cell redox homeostasis GO:0045454 102 64 0,000 0,38807908 0,40056554 ! lymphocyte mediated immunity GO:0002449 114 64 0,000 0,38807908 0,40039377 ! single fertilization GO:0007338 75 64 0,000 0,38807908 0,40022215 ! aminoglycan metabolic process GO:0006022 102 65 0,000 0,3927622 0,40487826 ! regulation of cytokine biosynthetic process GO:0042035 95 65 0,000 0,3927622 0,40470487 ! fatty acid biosynthetic process GO:0006633 124 66 0,000 0,39740964 0,40931832 ! extracellular matrix organization GO:0030198 133 66 0,000 0,39740964 0,40914317 ! developmental maturation GO:0021700 116 66 0,000 0,39740964 0,40896817 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 109 67 0,000 0,40202166 0,41353746 ! hexose catabolic process GO:0019320 104 67 0,000 0,40202166 0,41336073 ! amino acid transport GO:0006865 125 68 0,000 0,40659853 0,41788811 ! membrane lipid metabolic process GO:0006643 117 68 0,000 0,40659853 0,41770968 ! viral reproduction GO:0016032 134 68 0,000 0,40659853 0,4175314 ! protein maturation by peptide bond cleavage GO:0051605 105 68 0,000 0,40659853 0,41735327 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 110 68 0,000 0,40659853 0,41717529 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 112 69 0,000 0,41114052 0,42165563 ! glycerolipid biosynthetic process GO:0045017 118 69 0,000 0,41114052 0,42147597 ! coenzyme biosynthetic process GO:0009108 102 69 0,000 0,41114052 0,42129646 ! antigen processing and presentation GO:0019882 104 69 0,000 0,41114052 0,42111711 ! amine catabolic process GO:0009310 117 71 0,000 0,42012093 0,43013232 ! acute inflammatory response GO:0002526 113 72 0,000 0,42455986 0,43449214 ! carbohydrate transport GO:0008643 110 72 0,000 0,42455986 0,43430741 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 115 72 0,000 0,42455986 0,43412283 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 118 72 0,000 0,42455986 0,43393841 ! learning or memory GO:0007611 147 73 0,000 0,42896496 0,43825465 ! lipoprotein metabolic process GO:0042157 131 73 0,000 0,42896496 0,43806863 ! fertilization GO:0009566 90 73 0,000 0,42896496 0,43788277 ! transition metal ion transport GO:0000041 126 74 0,000 0,43333648 0,44215758 ! neurotransmitter transport GO:0006836 123 74 0,000 0,43333648 0,44197015 ! regulation of actin cytoskeleton organization GO:0032956 149 74 0,000 0,43333648 0,44178287 ! leukocyte mediated immunity GO:0002443 128 74 0,000 0,43333648 0,44159575 ! eye development GO:0001654 143 74 0,000 0,43333648 0,4414088 ! defense response to bacterium GO:0042742 89 76 0,000 0,44197982 0,45002262 ! monosaccharide catabolic process GO:0046365 115 76 0,000 0,44197982 0,44983225 ! neuropeptide signaling pathway GO:0007218 107 77 0,000 0,44625213 0,45398843 ! regulation of actin filament-based process GO:0032970 152 77 0,000 0,44625213 0,45379655 ! positive regulation of ligase activity GO:0051351 124 77 0,000 0,44625213 0,45360483 ! transcription initiation from RNA polymerase II promoter GO:0006367 121 78 0,000 0,45049188 0,45772106 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 154 79 0,000 0,45469931 0,46180099 ! sensory perception of chemical stimulus GO:0007606 109 79 0,000 0,45469931 0,46160613 ! activation of protein kinase activity GO:0032147 147 79 0,000 0,45469931 0,46141144 ! regulation of synaptic transmission GO:0050804 134 79 0,000 0,45469931 0,46121692 ! inorganic anion transport GO:0015698 138 80 0,000 0,45887466 0,46525597 ! digestion GO:0007586 112 81 0,000 0,46301817 0,46925936 ! cholesterol metabolic process GO:0008203 136 82 0,000 0,4671301 0,47322738 ! regulation of transmission of nerve impulse GO:0051969 141 84 0,000 0,47526014 0,4812609 ! response to unfolded protein GO:0006986 131 85 0,000 0,47927872 0,48512604 ! nucleosome assembly GO:0006334 122 85 0,000 0,47927872 0,48492204 ! one-carbon metabolic process GO:0006730 154 85 0,000 0,47927872 0,4847182 ! amine biosynthetic process GO:0009309 138 86 0,000 0,48326667 0,48854605 ! oxidative phosphorylation GO:0006119 133 86 0,000 0,48326667 0,48834086 ! chromatin assembly GO:0031497 124 86 0,000 0,48326667 0,48813585 ! alcohol catabolic process GO:0046164 130 86 0,000 0,48326667 0,48793101 ! amine transport GO:0015837 155 86 0,000 0,48326667 0,48772634 ! nitrogen compound catabolic process GO:0044270 143 87 0,000 0,4872242 0,49151422 ! cellular respiration GO:0045333 135 88 0,000 0,49115155 0,4952685 ! regulation of neurological system process GO:0031644 148 88 0,000 0,49115155 0,49506101 ! ATP biosynthetic process GO:0006754 159 88 0,000 0,49115155 0,4948537 ! cellular defense response GO:0006968 114 89 0,000 0,49504896 0,4985717 ! protein-DNA complex assembly GO:0065004 130 90 0,000 0,49891664 0,50225667 ! sterol metabolic process GO:0016125 152 91 0,000 0,50275482 0,50590887 ! cofactor biosynthetic process GO:0051188 139 91 0,000 0,50275482 0,50569737 ! nucleosome organization GO:0034728 138 92 0,000 0,50656373 0,50931565 ! phospholipid biosynthetic process GO:0008654 167 92 0,000 0,50656373 0,5091029 ! vitamin metabolic process GO:0006766 139 92 0,000 0,50656373 0,50889033 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 160 93 0,000 0,5103436 0,51247358 GO:0010498|proteasomal protein catabolic process, ! carbohydrate biosynthetic process GO:0016051 141 93 0,000 0,5103436 0,51225978 ! biogenic amine metabolic process GO:0006576 155 94 0,000 0,51409463 0,51580971 ! transcription initiation GO:0006352 153 94 0,000 0,51409463 0,5155947 ! forebrain development GO:0030900 188 95 0,000 0,51781705 0,51911159 ! regulation of Rho protein signal transduction GO:0035023 213 95 0,000 0,51781705 0,51889538 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 167 96 0,000 0,52151108 0,52237954 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! detection of stimulus GO:0051606 151 96 0,000 0,52151108 0,52216215 ! ribonucleoside triphosphate biosynthetic process GO:0009201 168 97 0,000 0,52517692 0,52561384 ! nucleoside triphosphate biosynthetic process GO:0009142 169 98 0,000 0,52881481 0,52903469 ! Golgi vesicle transport GO:0048193 207 99 0,000 0,53242494 0,53242494