pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6311-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of protein stability GO:0031647 77 38 8,000 5,737E-12 1,401E-08 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 4,000 1,069E-10 1,305E-07 ! negative regulation of phosphorylation GO:0042326 52 24 6,000 2,733E-10 2,226E-07 ! negative regulation of phosphorus metabolic process GO:0010563 56 26 6,000 5,132E-10 3,134E-07 GO:0045936|negative regulation of phosphate metabolic process, ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 5,000 1,454E-09 7,106E-07 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 4,000 4,385E-09 1,785E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 7,000 7,438E-09 2,596E-06 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 4,000 7,992E-09 2,441E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of cell-matrix adhesion GO:0001952 81 23 5,000 1,144E-08 3,106E-06 GO:0010810|regulation of cell-substrate adhesion, ! phospholipid dephosphorylation GO:0046839 12 5 3,000 1,266E-08 3,094E-06 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 4,000 3,403E-08 7,558E-06 ! negative regulation of cell migration GO:0030336 122 46 6,000 3,697E-08 7,527E-06 ! negative regulation of protein modification process GO:0031400 66 28 5,000 4,145E-08 7,79E-06 ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 8,765E-08 1,529E-05 ! endothelial cell migration GO:0043542 31 17 4,000 1,034E-07 1,683E-05 ! negative regulation of cell motion GO:0051271 142 55 6,000 1,327E-07 2,026E-05 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 1,743E-07 2,505E-05 ! negative regulation of cell adhesion GO:0007162 94 37 5,000 2,424E-07 3,29E-05 ! lipid modification GO:0030258 112 60 6,000 2,45E-07 3,15E-05 ! apoptotic mitochondrial changes GO:0008637 42 20 4,000 2,544E-07 3,108E-05 ! induction of positive chemotaxis GO:0050930 17 9 3,000 3,12E-07 3,63E-05 ! regulation of cell adhesion GO:0030155 241 92 7,000 3,379E-07 3,752E-05 ! positive regulation of locomotion GO:0040017 44 22 4,000 4,272E-07 4,537E-05 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of insulin receptor signaling pathway GO:0046626 22 10 3,000 5,171E-07 5,263E-05 ! regulation of chemotaxis GO:0050920 45 23 4,000 5,426E-07 5,303E-05 ! negative regulation of protein kinase activity GO:0006469 144 69 6,000 6,481E-07 6,089E-05 ! negative regulation of kinase activity GO:0033673 145 70 6,000 7,157E-07 6,476E-05 ! regulation of behavior GO:0050795 48 25 4,000 8,469E-07 7,389E-05 ! negative regulation of transferase activity GO:0051348 155 74 6,000 1,049E-06 8,834E-05 ! regulation of B cell proliferation GO:0030888 22 12 3,000 1,205E-06 9,814E-05 ! regulation of positive chemotaxis GO:0050926 22 12 3,000 1,205E-06 9,498E-05 GO:0050927|positive regulation of positive chemotaxis, ! negative regulation of protein kinase cascade GO:0010741 72 30 4,000 2,206E-06 1,684E-04 ! release of cytochrome c from mitochondria GO:0001836 31 14 3,000 2,41E-06 1,784E-04 ! response to UV GO:0009411 120 55 5,000 2,714E-06 1,95E-04 ! regulation of the force of heart contraction GO:0002026 31 15 3,000 3,268E-06 2,281E-04 ! actin cytoskeleton reorganization GO:0031532 38 15 3,000 3,268E-06 2,217E-04 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 2,000 3,568E-06 2,356E-04 ! positive regulation of cell migration GO:0030335 137 58 5,000 3,722E-06 2,393E-04 ! cardiac muscle tissue development GO:0048738 34 17 3,000 5,634E-06 3,529E-04 ! neutrophil chemotaxis GO:0030593 29 17 3,000 5,634E-06 3,441E-04 ! interphase of mitotic cell cycle GO:0051329 224 98 6,000 6,97E-06 4,153E-04 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 2,000 7,099E-06 4,129E-04 ! positive regulation of cell motion GO:0051272 157 65 5,000 7,286E-06 4,139E-04 ! negative regulation of binding GO:0051100 71 39 4,000 8,457E-06 4,696E-04 ! inositol metabolic process GO:0006020 33 19 3,000 9,072E-06 4,925E-04 ! mitotic chromosome condensation GO:0007076 37 19 3,000 9,072E-06 4,818E-04 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 5,000 1,032E-05 5,367E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 2,000 1,236E-05 6,29E-04 ! B cell lineage commitment GO:0002326 21 7 2,000 1,236E-05 6,161E-04 ! T cell lineage commitment GO:0002360 16 7 2,000 1,236E-05 6,038E-04 ! positive regulation of response to external stimulus GO:0032103 88 44 4,000 1,549E-05 7,422E-04 ! protein stabilization GO:0050821 41 22 3,000 1,684E-05 7,909E-04 ! induction of apoptosis by intracellular signals GO:0008629 95 45 4,000 1,733E-05 7,988E-04 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 4,000 1,933E-05 8,746E-04 ! leukocyte migration GO:0050900 75 46 4,000 1,933E-05 8,587E-04 ! ER overload response GO:0006983 13 8 2,000 1,967E-05 8,58E-04 ! regulation of T cell differentiation in the thymus GO:0033081 14 8 2,000 1,967E-05 8,43E-04 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 2,000 1,967E-05 8,284E-04 ! regulation of mast cell proliferation GO:0070666 89 49 4,000 2,643E-05 1,094E-03 ! chromosome condensation GO:0030261 48 25 3,000 2,863E-05 1,166E-03 ! T cell selection GO:0045058 27 9 2,000 2,935E-05 1,175E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 2,000 2,935E-05 1,156E-03 ! regulation of leukocyte proliferation GO:0070663 97 53 4,000 3,885E-05 1,507E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 2,000 4,17E-05 1,592E-03 ! positive regulation of B cell proliferation GO:0030890 18 10 2,000 4,17E-05 1,567E-03 ! regulation of DNA replication GO:0006275 105 56 4,000 5,083E-05 1,881E-03 ! positive regulation of MAP kinase activity GO:0043406 174 93 5,000 5,691E-05 2,075E-03 ! chondrocyte differentiation GO:0002062 27 11 2,000 5,704E-05 2,049E-03 ! positive regulation of leukocyte migration GO:0002687 28 11 2,000 5,704E-05 2,019E-03 ! negative regulation of glucose import GO:0046325 18 11 2,000 5,704E-05 1,991E-03 GO:0010829|negative regulation of glucose transport, ! regulation of B cell activation GO:0050864 55 30 3,000 6,03E-05 2,075E-03 ! regulation of DNA metabolic process GO:0051052 188 97 5,000 7,205E-05 2,445E-03 ! regulation of leukocyte migration GO:0002685 29 12 2,000 7,565E-05 2,532E-03 ! negative regulation of mast cell proliferation GO:0070667 24 12 2,000 7,565E-05 2,497E-03 GO:0042130|negative regulation of T cell proliferation, ! leukocyte chemotaxis GO:0030595 55 33 3,000 8,853E-05 2,884E-03 GO:0060326|cell chemotaxis, ! integrin-mediated signaling pathway GO:0007229 160 64 4,000 9,684E-05 3,113E-03 ! ribosomal large subunit biogenesis GO:0042273 13 13 2,000 9,782E-05 3,104E-03 ! cytoplasmic sequestering of protein GO:0051220 25 13 2,000 9,782E-05 3,064E-03 ! negative regulation of cell growth GO:0030308 142 67 4,000 1,206E-04 3,728E-03 ! T cell differentiation in the thymus GO:0033077 37 14 2,000 1,238E-04 3,782E-03 ! response to gamma radiation GO:0010332 30 14 2,000 1,238E-04 3,735E-03 ! mitotic sister chromatid segregation GO:0000070 63 36 3,000 1,253E-04 3,734E-03 ! negative regulation of DNA binding GO:0043392 67 36 3,000 1,253E-04 3,689E-03 ! negative regulation of cell size GO:0045792 144 69 4,000 1,387E-04 4,033E-03 ! sister chromatid segregation GO:0000819 65 37 3,000 1,397E-04 4,016E-03 ! negative regulation of bone remodeling GO:0046851 34 15 2,000 1,54E-04 4,374E-03 ! negative regulation of tissue remodeling GO:0034104 37 16 2,000 1,885E-04 5,294E-03 ! negative regulation of leukocyte proliferation GO:0070664 32 16 2,000 1,885E-04 5,234E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! cell-matrix adhesion GO:0007160 181 76 4,000 2,189E-04 6,008E-03 ! regulation of protein binding GO:0043393 33 17 2,000 2,277E-04 6,181E-03 ! negative regulation of homeostatic process GO:0032845 36 17 2,000 2,277E-04 6,113E-03 ! regulation of intracellular protein transport GO:0033157 86 42 3,000 2,303E-04 6,114E-03 ! T cell differentiation GO:0030217 93 42 3,000 2,303E-04 6,049E-03 ! regulation of T cell differentiation GO:0045580 78 42 3,000 2,303E-04 5,984E-03 ! phosphoinositide metabolic process GO:0030384 146 77 4,000 2,327E-04 5,985E-03 ! regulation of T cell proliferation GO:0042129 80 43 3,000 2,525E-04 6,425E-03 ! response to retinoic acid GO:0032526 31 18 2,000 2,718E-04 6,846E-03 ! negative regulation of protein catabolic process GO:0042177 42 18 2,000 2,718E-04 6,776E-03 ! defense response to virus GO:0051607 43 18 2,000 2,718E-04 6,707E-03 ! polyol metabolic process GO:0019751 77 45 3,000 3,014E-04 7,363E-03 ! cell-substrate adhesion GO:0031589 189 82 4,000 3,122E-04 7,552E-03 ! G1 phase of mitotic cell cycle GO:0000080 39 19 2,000 3,211E-04 7,69E-03 ! response to vitamin A GO:0033189 32 19 2,000 3,211E-04 7,615E-03 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 3,283E-04 7,711E-03 ! pigmentation GO:0043473 103 46 3,000 3,283E-04 7,638E-03 ! T cell activation GO:0042110 189 84 4,000 3,492E-04 8,048E-03 ! negative regulation of transport GO:0051051 164 85 4,000 3,689E-04 8,423E-03 ! negative regulation of growth GO:0045926 168 85 4,000 3,689E-04 8,345E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 2,000 3,757E-04 8,422E-03 ! response to vitamin GO:0033273 36 20 2,000 3,757E-04 8,345E-03 ! peptidyl-serine phosphorylation GO:0018105 44 20 2,000 3,757E-04 8,27E-03 ! fatty acid beta-oxidation GO:0006635 36 20 2,000 3,757E-04 8,196E-03 ! regulation of glucose import GO:0046324 30 20 2,000 3,757E-04 8,123E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 41 20 2,000 3,757E-04 8,052E-03 ! mitochondrion organization GO:0007005 159 87 4,000 4,108E-04 8,726E-03 ! regulation of lymphocyte differentiation GO:0045619 92 49 3,000 4,191E-04 8,827E-03 ! cell structure disassembly during apoptosis GO:0006921 32 21 2,000 4,361E-04 9,105E-03 ! plasma membrane fusion GO:0045026 33 21 2,000 4,361E-04 9,028E-03 ! regulation of vasoconstriction GO:0019229 40 21 2,000 4,361E-04 8,952E-03 ! positive regulation of inflammatory response GO:0050729 41 21 2,000 4,361E-04 8,877E-03 ! activation of caspase activity GO:0006919 95 50 3,000 4,53E-04 9,147E-03 ! regulation of DNA binding GO:0051101 167 89 4,000 4,561E-04 9,134E-03 ! regulation of cell cycle process GO:0010564 161 90 4,000 4,802E-04 9,537E-03 ! negative regulation of immune system process GO:0002683 101 51 3,000 4,889E-04 9,631E-03 ! negative regulation of protein ubiquitination GO:0031397 10 5 1,000 5,015E-04 9,801E-03 ! positive regulation of muscle development GO:0048636 15 5 1,000 5,015E-04 9,723E-03 GO:0045844|positive regulation of striated muscle development, ! negative regulation of bone resorption GO:0045779 10 5 1,000 5,015E-04 9,647E-03 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 1,000 5,015E-04 9,571E-03 ! epithelial cell proliferation GO:0050673 9 5 1,000 5,015E-04 9,497E-03 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 1,000 5,015E-04 9,424E-03 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! microvillus organization GO:0032528 8 5 1,000 5,015E-04 9,352E-03 GO:0030033|microvillus assembly, ! positive regulation of filopodium assembly GO:0051491 16 5 1,000 5,015E-04 9,281E-03 GO:0051489|regulation of filopodium assembly, ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 5,015E-04 9,212E-03 ! virus-infected cell apoptosis GO:0006926 7 5 1,000 5,015E-04 9,143E-03 ! peptidyl-threonine phosphorylation GO:0018107 20 5 1,000 5,015E-04 9,075E-03 ! G2/M transition checkpoint GO:0031576 8 5 1,000 5,015E-04 9,008E-03 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 1,000 5,015E-04 8,943E-03 ! negative regulation of T cell mediated immunity GO:0002710 15 5 1,000 5,015E-04 8,878E-03 GO:0002707|negative regulation of lymphocyte mediated immunity, ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 1,000 5,015E-04 8,814E-03 ! B cell homeostasis GO:0001782 13 5 1,000 5,015E-04 8,751E-03 ! metaphase GO:0051323 11 5 1,000 5,015E-04 8,689E-03 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 1,000 5,015E-04 8,628E-03 ! regulation of mitochondrial depolarization GO:0051900 14 5 1,000 5,015E-04 8,567E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 1,000 5,015E-04 8,508E-03 ! hemopoietic progenitor cell differentiation GO:0002244 14 5 1,000 5,015E-04 8,449E-03 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 1,000 5,015E-04 8,391E-03 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! protein insertion into membrane GO:0051205 17 5 1,000 5,015E-04 8,334E-03 ! stem cell division GO:0017145 11 5 1,000 5,015E-04 8,278E-03 GO:0048103|somatic stem cell division, ! inactivation of MAPK activity GO:0000188 45 22 2,000 5,023E-04 8,235E-03 ! cell aging GO:0007569 48 22 2,000 5,023E-04 8,18E-03 ! G1 phase GO:0051318 44 22 2,000 5,023E-04 8,126E-03 ! positive regulation of intracellular transport GO:0032388 42 22 2,000 5,023E-04 8,072E-03 ! peptidyl-serine modification GO:0018209 50 22 2,000 5,023E-04 8,02E-03 ! positive regulation of B cell activation GO:0050871 42 22 2,000 5,023E-04 7,968E-03 ! cartilage development GO:0051216 99 53 3,000 5,665E-04 8,928E-03 ! regulation of angiogenesis GO:0045765 125 54 3,000 6,084E-04 9,527E-03 ! regulation of muscle contraction GO:0006937 94 54 3,000 6,084E-04 9,467E-03 ! membrane fusion GO:0006944 122 54 3,000 6,084E-04 9,407E-03 ! epithelial tube morphogenesis GO:0060562 114 54 3,000 6,084E-04 9,348E-03 ! negative regulation of multicellular organismal process GO:0051241 174 95 4,000 6,15E-04 9,391E-03 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 2,000 6,532E-04 9,911E-03 ! negative regulation of catabolic process GO:0009895 52 24 2,000 6,532E-04 9,85E-03 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 2,000 6,532E-04 9,79E-03 ! regulation of protein localization GO:0032880 188 97 4,000 6,762E-04 0,01007332 ! regulation of protein catabolic process GO:0042176 126 56 3,000 6,987E-04 0,01034544 ! leukocyte differentiation GO:0002521 232 98 4,000 7,085E-04 0,01042664 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 2,000 7,383E-04 0,01080102 ! negative regulation of DNA replication GO:0008156 45 25 2,000 7,383E-04 0,01073673 ! lymphocyte proliferation GO:0046651 55 25 2,000 7,383E-04 0,0106732 ! positive regulation of caspase activity GO:0043280 108 57 3,000 7,473E-04 0,01073891 GO:0010952|positive regulation of peptidase activity, ! regulation of intracellular transport GO:0032386 108 57 3,000 7,473E-04 0,01067611 ! negative regulation of cell-cell adhesion GO:0022408 13 6 1,000 7,487E-04 0,010634 ! thymic T cell selection GO:0045061 16 6 1,000 7,487E-04 0,01057253 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 1,000 7,487E-04 0,01051177 ! vascular smooth muscle contraction GO:0014829 13 6 1,000 7,487E-04 0,0104517 ! early endosome to late endosome transport GO:0045022 16 6 1,000 7,487E-04 0,01039231 ! establishment of spindle localization GO:0051293 16 6 1,000 7,487E-04 0,0103336 GO:0051653|spindle localization, ! neural nucleus development GO:0048857 19 6 1,000 7,487E-04 0,01027555 ! regulation of myeloid cell apoptosis GO:0033032 14 6 1,000 7,487E-04 0,01021814 ! negative regulation of neuroblast proliferation GO:0007406 25 6 1,000 7,487E-04 0,01016137 ! progesterone metabolic process GO:0042448 12 6 1,000 7,487E-04 0,01010523 ! cytoplasmic microtubule organization GO:0031122 18 6 1,000 7,487E-04 0,01004971 ! negative regulation of B cell activation GO:0050869 14 6 1,000 7,487E-04 9,995E-03 ! cellular anion homeostasis GO:0030002 11 6 1,000 7,487E-04 9,94E-03 GO:0055081|anion homeostasis, ! aging GO:0007568 112 58 3,000 7,982E-04 0,01054022 ! regulation of transcription factor import into nucleus GO:0042990 58 26 2,000 8,303E-04 0,01090498 ! response to endoplasmic reticulum stress GO:0034976 46 26 2,000 8,303E-04 0,01084666 ! neural tube closure GO:0001843 58 26 2,000 8,303E-04 0,01078896 GO:0060606|tube closure, ! tube lumen formation GO:0035148 59 27 2,000 9,291E-04 0,01200991 ! mitochondrial membrane organization GO:0007006 60 27 2,000 9,291E-04 0,0119467 ! leukocyte proliferation GO:0070661 59 27 2,000 9,291E-04 0,01188415 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 2,000 9,291E-04 0,01182226 ! regulation of heart contraction GO:0008016 123 61 3,000 9,655E-04 0,01222105 ! negative regulation of response to stimulus GO:0048585 106 61 3,000 9,655E-04 0,01215805 ! regulation of homeostatic process GO:0032844 148 62 3,000 1,026E-03 0,01285804 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 1,035E-03 0,01290256 ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 2,000 1,035E-03 0,01283707 ! lipid oxidation GO:0034440 48 28 2,000 1,035E-03 0,01277223 GO:0019395|fatty acid oxidation, ! prostate gland development GO:0030850 14 7 1,000 1,043E-03 0,01280699 ! organ growth GO:0035265 15 7 1,000 1,043E-03 0,01274295 ! G1 DNA damage checkpoint GO:0031571 20 7 1,000 1,043E-03 0,01267955 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 1,000 1,043E-03 0,01261678 GO:0002714|positive regulation of B cell mediated immunity, ! peptidyl-threonine modification GO:0018210 26 7 1,000 1,043E-03 0,01255463 ! regulation of protein homodimerization activity GO:0043496 18 7 1,000 1,043E-03 0,01249309 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 1,000 1,043E-03 0,01243215 ! regulation of helicase activity GO:0051095 16 7 1,000 1,043E-03 0,0123718 ! regulation of protein export from nucleus GO:0046825 10 7 1,000 1,043E-03 0,01231203 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 1,043E-03 0,01225284 ! mRNA stabilization GO:0048255 18 7 1,000 1,043E-03 0,01219421 GO:0043489|RNA stabilization, ! positive regulation of isotype switching GO:0045830 17 7 1,000 1,043E-03 0,01213614 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 1,000 1,043E-03 0,01207863 ! phasic smooth muscle contraction GO:0014821 12 7 1,000 1,043E-03 0,01202165 ! monocyte differentiation GO:0030224 16 7 1,000 1,043E-03 0,01196521 ! fibrinolysis GO:0042730 11 7 1,000 1,043E-03 0,0119093 ! skeletal system morphogenesis GO:0048705 118 63 3,000 1,09E-03 0,01238341 ! ER-nuclear signaling pathway GO:0006984 52 29 2,000 1,149E-03 0,0129902 ! primary neural tube formation GO:0014020 61 29 2,000 1,149E-03 0,01293034 ! protein amino acid autophosphorylation GO:0046777 157 64 3,000 1,156E-03 0,01295485 ! negative regulation of transcription regulator activity GO:0090048 57 30 2,000 1,269E-03 0,0141611 GO:0043433|negative regulation of transcription factor activity, ! chromosome segregation GO:0007059 127 67 3,000 1,371E-03 0,01522942 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 1,384E-03 0,01530364 ! oligopeptide transport GO:0006857 16 8 1,000 1,384E-03 0,0152347 ! macrophage chemotaxis GO:0048246 12 8 1,000 1,384E-03 0,01516639 ! T-helper 1 type immune response GO:0042088 12 8 1,000 1,384E-03 0,01509868 ! inositol phosphate-mediated signaling GO:0048016 11 8 1,000 1,384E-03 0,01503157 ! pigment granule organization GO:0048753 17 8 1,000 1,384E-03 0,01496506 ! activation of caspase activity by cytochrome c GO:0008635 14 8 1,000 1,384E-03 0,01489914 ! regulation of pigmentation during development GO:0048070 25 8 1,000 1,384E-03 0,01483379 ! melanin metabolic process GO:0006582 17 8 1,000 1,384E-03 0,01476901 ! positive regulation of endothelial cell migration GO:0010595 19 8 1,000 1,384E-03 0,0147048 ! macrophage activation GO:0042116 13 8 1,000 1,384E-03 0,01464114 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 1,000 1,384E-03 0,01457803 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,384E-03 0,01451547 ! response to UV-B GO:0010224 17 8 1,000 1,384E-03 0,01445344 ! response to tumor cell GO:0002347 16 8 1,000 1,384E-03 0,01439193 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 1,000 1,384E-03 0,01433095 GO:0002688|regulation of leukocyte chemotaxis, ! B cell receptor signaling pathway GO:0050853 22 8 1,000 1,384E-03 0,01427048 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 1,000 1,384E-03 0,01421052 ! positive regulation of smooth muscle contraction GO:0045987 15 8 1,000 1,384E-03 0,01415106 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 1,000 1,384E-03 0,0140921 ! cell junction assembly GO:0034329 85 31 2,000 1,398E-03 0,01417237 ! cellular response to extracellular stimulus GO:0031668 52 31 2,000 1,398E-03 0,01411381 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 2,000 1,398E-03 0,01405572 ! negative regulation of leukocyte activation GO:0002695 60 31 2,000 1,398E-03 0,01399812 ! fatty acid catabolic process GO:0009062 54 31 2,000 1,398E-03 0,01394098 ! urogenital system development GO:0001655 149 69 3,000 1,53E-03 0,01519159 ! regulation of protein import into nucleus GO:0042306 69 32 2,000 1,535E-03 0,01517854 ! response to ionizing radiation GO:0010212 74 33 2,000 1,679E-03 0,01654186 ! negative regulation of protein transport GO:0051224 74 33 2,000 1,679E-03 0,01647542 ! cell cycle checkpoint GO:0000075 145 71 3,000 1,7E-03 0,01661521 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 1,000 1,772E-03 0,01724277 ! microtubule bundle formation GO:0001578 22 9 1,000 1,772E-03 0,01717435 ! receptor clustering GO:0043113 20 9 1,000 1,772E-03 0,01710647 ! regulation of mitochondrial membrane potential GO:0051881 19 9 1,000 1,772E-03 0,01703912 ! postreplication repair GO:0006301 25 9 1,000 1,772E-03 0,0169723 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 1,000 1,772E-03 0,016906 GO:0002820|negative regulation of adaptive immune response, ! negative regulation of MAP kinase activity GO:0043407 78 34 2,000 1,832E-03 0,01741555 ! regulation of caspase activity GO:0043281 136 74 3,000 1,98E-03 0,01875065 ! DNA damage checkpoint GO:0000077 78 35 2,000 1,993E-03 0,0188021 ! negative regulation of DNA metabolic process GO:0051053 65 35 2,000 1,993E-03 0,01872979 ! regulation of striated muscle tissue development GO:0016202 81 35 2,000 1,993E-03 0,01865803 ! calcium-mediated signaling GO:0019722 67 35 2,000 1,993E-03 0,01858681 ! regulation of transcription factor activity GO:0051090 137 75 3,000 2,08E-03 0,01932283 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 3,000 2,08E-03 0,01924964 ! regulation of muscle development GO:0048634 82 36 2,000 2,163E-03 0,01994195 ! lymphocyte differentiation GO:0030098 193 76 3,000 2,184E-03 0,02005461 ! regulation of smooth muscle cell migration GO:0014910 27 10 1,000 2,204E-03 0,02016648 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 1,000 2,204E-03 0,02009124 GO:0007520|myoblast fusion, ! positive regulation of heart contraction GO:0045823 17 10 1,000 2,204E-03 0,02001655 ! lung alveolus development GO:0048286 26 10 1,000 2,204E-03 0,01994241 ! negative regulation of striated muscle development GO:0045843 26 10 1,000 2,204E-03 0,01986882 ! B cell proliferation GO:0042100 19 10 1,000 2,204E-03 0,01979578 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 1,000 2,204E-03 0,01972326 ! motor axon guidance GO:0008045 22 10 1,000 2,204E-03 0,01965128 ! regulation of bone resorption GO:0045124 25 10 1,000 2,204E-03 0,01957982 ! alpha-beta T cell differentiation GO:0046632 24 10 1,000 2,204E-03 0,01950888 ! response to dsRNA GO:0043331 23 10 1,000 2,204E-03 0,01943845 ! regulation of B cell differentiation GO:0045577 24 10 1,000 2,204E-03 0,01936853 ! blastocyst formation GO:0001825 18 10 1,000 2,204E-03 0,01929911 ! response to nicotine GO:0035094 20 10 1,000 2,204E-03 0,01923018 ! negative regulation of immune effector process GO:0002698 23 10 1,000 2,204E-03 0,01916175 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 1,000 2,204E-03 0,0190938 ! regulation of endopeptidase activity GO:0052548 141 77 3,000 2,29E-03 0,0197727 ! regulation of catabolic process GO:0009894 173 77 3,000 2,29E-03 0,01970307 ! cell junction organization GO:0034330 96 37 2,000 2,342E-03 0,02007294 ! maintenance of protein location in cell GO:0032507 89 37 2,000 2,342E-03 0,02000275 ! regulation of microtubule-based process GO:0032886 86 37 2,000 2,342E-03 0,01993306 ! negative regulation of cell activation GO:0050866 69 37 2,000 2,342E-03 0,01986384 ! positive regulation of DNA metabolic process GO:0051054 77 38 2,000 2,529E-03 0,02137931 ! DNA integrity checkpoint GO:0031570 82 38 2,000 2,529E-03 0,02130559 ! neural tube formation GO:0001841 79 38 2,000 2,529E-03 0,02123238 ! negative regulation of muscle development GO:0048635 27 11 1,000 2,681E-03 0,02243162 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 2,681E-03 0,02235506 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 1,000 2,681E-03 0,02227902 ! blood vessel remodeling GO:0001974 30 11 1,000 2,681E-03 0,0222035 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 1,000 2,681E-03 0,02212849 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 2,681E-03 0,02205398 ! syncytium formation GO:0006949 20 11 1,000 2,681E-03 0,02197997 ! regulation of intracellular pH GO:0051453 21 11 1,000 2,681E-03 0,02190646 ! behavioral fear response GO:0001662 27 11 1,000 2,681E-03 0,02183344 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 1,000 2,681E-03 0,0217609 ! negative regulation of ossification GO:0030279 27 11 1,000 2,681E-03 0,02168885 ! alpha-beta T cell activation GO:0046631 26 11 1,000 2,681E-03 0,02161727 ! positive regulation of T cell mediated immunity GO:0002711 26 11 1,000 2,681E-03 0,02154616 ! vasoconstriction GO:0042310 20 11 1,000 2,681E-03 0,02147551 ! regulation of isotype switching GO:0045191 24 11 1,000 2,681E-03 0,02140533 ! thymus development GO:0048538 29 11 1,000 2,681E-03 0,02133561 ! oocyte development GO:0048599 20 11 1,000 2,681E-03 0,02126634 ! T cell receptor signaling pathway GO:0050852 29 11 1,000 2,681E-03 0,02119751 ! mitotic cell cycle checkpoint GO:0007093 76 39 2,000 2,726E-03 0,02147895 ! positive regulation of leukocyte proliferation GO:0070665 70 39 2,000 2,726E-03 0,02140989 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! response to hypoxia GO:0001666 178 81 3,000 2,754E-03 0,02156541 ! positive regulation of phosphorylation GO:0042327 149 81 3,000 2,754E-03 0,02149651 ! regulation of peptidase activity GO:0052547 150 82 3,000 2,879E-03 0,02240235 ! response to drug GO:0042493 149 83 3,000 3,008E-03 0,02333221 ! response to oxygen levels GO:0070482 183 83 3,000 3,008E-03 0,02325837 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 3,000 3,008E-03 0,023185 GO:0045937|positive regulation of phosphate metabolic process, ! response to nutrient GO:0007584 135 84 3,000 3,141E-03 0,02413356 ! maintenance of protein location GO:0045185 95 41 2,000 3,146E-03 0,0240928 ! embryonic epithelial tube formation GO:0001838 85 41 2,000 3,146E-03 0,02401751 ! dopamine receptor signaling pathway GO:0007212 28 12 1,000 3,202E-03 0,02437096 ! regulation of cell projection assembly GO:0060491 33 12 1,000 3,202E-03 0,02429527 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 1,000 3,202E-03 0,02422005 ! T cell proliferation GO:0042098 32 12 1,000 3,202E-03 0,0241453 ! focal adhesion formation GO:0048041 37 12 1,000 3,202E-03 0,02407101 ! histone acetylation GO:0016573 27 12 1,000 3,202E-03 0,02399717 ! peptidyl-lysine modification GO:0018205 21 12 1,000 3,202E-03 0,02392379 ! T cell homeostasis GO:0043029 28 12 1,000 3,202E-03 0,02385085 ! oocyte differentiation GO:0009994 21 12 1,000 3,202E-03 0,02377835 ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 1,000 3,202E-03 0,0237063 ! establishment of cell polarity GO:0030010 21 12 1,000 3,202E-03 0,02363468 ! localization within membrane GO:0051668 26 12 1,000 3,202E-03 0,02356349 ! regulation of protein transport GO:0051223 165 87 3,000 3,564E-03 0,02614844 GO:0070201|regulation of establishment of protein localization, ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 2,000 3,604E-03 0,02636165 ! cartilage condensation GO:0001502 22 13 1,000 3,767E-03 0,02746867 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 1,000 3,767E-03 0,02738692 ! regulation of skeletal muscle fiber development GO:0048742 32 13 1,000 3,767E-03 0,02730565 ! response to X-ray GO:0010165 28 13 1,000 3,767E-03 0,02722487 ! membrane protein proteolysis GO:0033619 33 13 1,000 3,767E-03 0,02714456 GO:0006509|membrane protein ectodomain proteolysis, ! negative regulation of mitotic cell cycle GO:0045930 35 13 1,000 3,767E-03 0,02706472 ! regulation of monooxygenase activity GO:0032768 35 13 1,000 3,767E-03 0,02698535 ! gland morphogenesis GO:0022612 31 13 1,000 3,767E-03 0,02690645 ! spleen development GO:0048536 24 13 1,000 3,767E-03 0,026828 ! regulation of mRNA stability GO:0043488 32 13 1,000 3,767E-03 0,02675002 ! digestive tract morphogenesis GO:0048546 31 13 1,000 3,767E-03 0,02667248 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! tube morphogenesis GO:0035239 194 89 3,000 3,867E-03 0,02730104 ! regulation of epithelial cell proliferation GO:0050678 122 45 2,000 4,101E-03 0,02887172 ! B cell differentiation GO:0030183 124 45 2,000 4,101E-03 0,02878876 ! maintenance of location in cell GO:0051651 101 45 2,000 4,101E-03 0,02870627 ! gland development GO:0048732 220 91 3,000 4,186E-03 0,02921774 ! positive regulation of protein transport GO:0051222 80 46 2,000 4,364E-03 0,03037464 ! rRNA transcription GO:0009303 28 14 1,000 4,374E-03 0,03035582 ! regulation of S phase GO:0033261 26 14 1,000 4,374E-03 0,03026983 ! myotube differentiation GO:0014902 26 14 1,000 4,374E-03 0,03018432 ! hair follicle morphogenesis GO:0031069 27 14 1,000 4,374E-03 0,03009929 ! cell-cell junction assembly GO:0007043 32 14 1,000 4,374E-03 0,03001474 ! regulation of heart rate GO:0002027 25 14 1,000 4,374E-03 0,02993067 ! fear response GO:0042596 34 14 1,000 4,374E-03 0,02984706 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 1,000 4,374E-03 0,02976393 GO:0060675|ureteric bud morphogenesis, ! negative regulation of protein import into nucleus GO:0042308 33 14 1,000 4,374E-03 0,02968125 ! regulation of cellular pH GO:0030641 27 14 1,000 4,374E-03 0,02959903 ! regulation of RNA stability GO:0043487 33 14 1,000 4,374E-03 0,02951726 ! neural tube development GO:0021915 91 47 2,000 4,637E-03 0,03120933 ! positive regulation of defense response GO:0031349 88 48 2,000 4,921E-03 0,0330253 ! mitochondrial transport GO:0006839 94 48 2,000 4,921E-03 0,03293482 ! cellular component disassembly GO:0022411 89 48 2,000 4,921E-03 0,03284483 ! vascular process in circulatory system GO:0003018 85 48 2,000 4,921E-03 0,03275534 ! male sex differentiation GO:0046661 93 48 2,000 4,921E-03 0,03266633 ! regulation of inflammatory response GO:0050727 84 48 2,000 4,921E-03 0,0325778 ! regulation of skeletal muscle tissue development GO:0048641 35 15 1,000 5,023E-03 0,03316556 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 5,023E-03 0,03307617 ! positive regulation of GTPase activity GO:0043547 43 15 1,000 5,023E-03 0,03298726 ! regulation of cell-cell adhesion GO:0022407 35 15 1,000 5,023E-03 0,03289882 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 1,000 5,023E-03 0,03281085 ! G1/S transition checkpoint GO:0031575 37 15 1,000 5,023E-03 0,03272336 ! intermediate filament cytoskeleton organization GO:0045104 34 15 1,000 5,023E-03 0,03263633 ! regulation of T cell mediated immunity GO:0002709 36 15 1,000 5,023E-03 0,03254976 ! cAMP biosynthetic process GO:0006171 25 15 1,000 5,023E-03 0,03246365 ! lymphocyte homeostasis GO:0002260 33 15 1,000 5,023E-03 0,03237799 ! sex differentiation GO:0007548 171 96 3,000 5,061E-03 0,0325367 ! regulation of T cell activation GO:0050863 175 96 3,000 5,061E-03 0,0324513 ! induction of apoptosis by extracellular signals GO:0008624 99 50 2,000 5,518E-03 0,03529023 ! regulation of protein ubiquitination GO:0031396 28 16 1,000 5,714E-03 0,03644518 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 1,000 5,714E-03 0,03635027 ! regulation of transmembrane transporter activity GO:0022898 27 16 1,000 5,714E-03 0,03625585 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! intermediate filament-based process GO:0045103 36 16 1,000 5,714E-03 0,03616192 ! negative regulation of immune response GO:0050777 38 16 1,000 5,714E-03 0,03606848 ! axon cargo transport GO:0008088 46 16 1,000 5,714E-03 0,03597552 ! positive regulation of protein import into nucleus GO:0042307 34 16 1,000 5,714E-03 0,03588304 ! DNA replication initiation GO:0006270 28 16 1,000 5,714E-03 0,03579103 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 1,000 5,714E-03 0,0356995 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 1,000 5,714E-03 0,03560842 ! positive regulation of neuron apoptosis GO:0043525 32 16 1,000 5,714E-03 0,03551782 ! peptide metabolic process GO:0006518 80 51 2,000 5,832E-03 0,03616441 ! skeletal muscle tissue development GO:0007519 223 100 3,000 5,843E-03 0,03614038 GO:0060538|skeletal muscle organ development, ! morphogenesis of embryonic epithelium GO:0016331 106 52 2,000 6,157E-03 0,03798581 ! positive regulation of cell killing GO:0031343 36 17 1,000 6,445E-03 0,03966112 ! metencephalon development GO:0022037 32 17 1,000 6,445E-03 0,03956147 ! negative regulation of cell cycle process GO:0010948 35 17 1,000 6,445E-03 0,03946231 ! embryonic forelimb morphogenesis GO:0035115 31 17 1,000 6,445E-03 0,03936366 ! signal complex assembly GO:0007172 47 17 1,000 6,445E-03 0,0392655 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 6,445E-03 0,03916782 GO:0031114|regulation of microtubule depolymerization, ! DNA fragmentation involved in apoptosis GO:0006309 27 17 1,000 6,445E-03 0,03907063 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 1,000 6,445E-03 0,03897392 GO:0002712|regulation of B cell mediated immunity, ! negative regulation of blood coagulation GO:0030195 25 17 1,000 6,445E-03 0,03887769 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 1,000 6,445E-03 0,03878193 ! regulation of neuron apoptosis GO:0043523 117 53 2,000 6,493E-03 0,0389727 ! regulation of cell shape GO:0008360 142 54 2,000 6,839E-03 0,04094978 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 1,000 7,217E-03 0,0431067 GO:0050886|endocrine process, ! regulation of viral genome replication GO:0045069 30 18 1,000 7,217E-03 0,04300157 ! epidermis morphogenesis GO:0048730 43 18 1,000 7,217E-03 0,04289694 ! cell-substrate junction assembly GO:0007044 56 18 1,000 7,217E-03 0,04279282 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 1,000 7,217E-03 0,04268921 ! regulation of immunoglobulin production GO:0002637 49 18 1,000 7,217E-03 0,04258609 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 7,217E-03 0,04248348 ! skeletal muscle fiber development GO:0048741 130 56 2,000 7,564E-03 0,044418 ! regulation of bone remodeling GO:0046850 143 57 2,000 7,942E-03 0,04653001 ! muscle fiber development GO:0048747 131 57 2,000 7,942E-03 0,0464187 ! pigmentation during development GO:0048066 42 19 1,000 8,028E-03 0,04680801 ! neuromuscular junction development GO:0007528 43 19 1,000 8,028E-03 0,04669656 ! regulation of endothelial cell migration GO:0010594 45 19 1,000 8,028E-03 0,04658564 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 1,000 8,028E-03 0,04647525 ! cellular pigmentation GO:0033059 37 19 1,000 8,028E-03 0,04636538 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 1,000 8,028E-03 0,04625603 ! regulation of tissue remodeling GO:0034103 146 58 2,000 8,332E-03 0,04789412 ! maintenance of location GO:0051235 124 58 2,000 8,332E-03 0,04778169 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 1,000 8,878E-03 0,05079563 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 8,878E-03 0,05067695 ! protein amino acid acetylation GO:0006473 41 20 1,000 8,878E-03 0,05055882 ! forelimb morphogenesis GO:0035136 35 20 1,000 8,878E-03 0,05044124 ! bile acid metabolic process GO:0008206 34 20 1,000 8,878E-03 0,05032421 ! response to alkaloid GO:0043279 38 20 1,000 8,878E-03 0,05020772 ! cell-cell junction organization GO:0045216 43 20 1,000 8,878E-03 0,05009176 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 1,000 8,878E-03 0,04997634 ! negative regulation of coagulation GO:0050819 30 20 1,000 8,878E-03 0,04986146 ! cytokine-mediated signaling pathway GO:0019221 112 61 2,000 9,568E-03 0,05360948 ! regulation of cell killing GO:0031341 46 21 1,000 9,767E-03 0,05460121 ! lipid phosphorylation GO:0046834 43 21 1,000 9,767E-03 0,05447655 ! cAMP metabolic process GO:0046058 41 21 1,000 9,767E-03 0,05435245 ! C21-steroid hormone metabolic process GO:0008207 38 21 1,000 9,767E-03 0,05422893 ! ovarian follicle development GO:0001541 39 21 1,000 9,767E-03 0,05410596 ! smooth muscle contraction GO:0006939 48 21 1,000 9,767E-03 0,05398355 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 1,000 9,767E-03 0,05386169 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 1,000 9,767E-03 0,05374038 ! negative regulation of angiogenesis GO:0016525 49 21 1,000 9,767E-03 0,05361961 ! negative regulation of intracellular transport GO:0032387 44 21 1,000 9,767E-03 0,05349939 ! actin filament-based movement GO:0030048 47 21 1,000 9,767E-03 0,0533797 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 1,000 9,767E-03 0,05326055 ! DNA damage response, signal transduction GO:0042770 136 62 2,000 0,01000194 0,05442036 ! mesoderm development GO:0007498 128 63 2,000 0,01044755 0,05671857 ! microtubule-based transport GO:0010970 59 22 1,000 0,01069345 0,05792483 ! hindlimb morphogenesis GO:0035137 47 22 1,000 0,01069345 0,05779668 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 1,000 0,01069345 0,05766909 ! cellular response to starvation GO:0009267 37 22 1,000 0,01069345 0,05754207 ! apoptotic nuclear changes GO:0030262 34 22 1,000 0,01069345 0,0574156 ! ureteric bud development GO:0001657 50 22 1,000 0,01069345 0,05728969 ! renal system process GO:0003014 42 22 1,000 0,01069345 0,05716433 ! positive regulation of adaptive immune response GO:0002821 42 22 1,000 0,01069345 0,05703952 ! response to glucocorticoid stimulus GO:0051384 42 22 1,000 0,01069345 0,05691525 ! response to cytokine stimulus GO:0034097 69 22 1,000 0,01069345 0,05679152 ! activation of JUN kinase activity GO:0007257 47 22 1,000 0,01069345 0,05666833 ! gut development GO:0048565 44 22 1,000 0,01069345 0,05654567 ! response to peptide hormone stimulus GO:0043434 129 64 2,000 0,01090451 0,05753717 ! positive regulation of DNA replication GO:0045740 44 23 1,000 0,01165715 0,06137593 ! regeneration GO:0031099 42 23 1,000 0,01165715 0,06124393 ! axis specification GO:0009798 43 23 1,000 0,01165715 0,06111251 ! regulation of DNA recombination GO:0000018 51 23 1,000 0,01165715 0,06098165 ! response to ethanol GO:0045471 47 23 1,000 0,01165715 0,06085134 ! activation of pro-apoptotic gene products GO:0008633 51 23 1,000 0,01165715 0,0607216 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 1,000 0,01165715 0,0605924 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 1,000 0,01165715 0,06046376 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 1,000 0,01165715 0,06033566 ! gonad development GO:0008406 115 66 2,000 0,01185268 0,06121799 ! activation of MAPK activity GO:0000187 124 67 2,000 0,01234399 0,06362104 ! myeloid cell differentiation GO:0030099 126 67 2,000 0,01234399 0,0634871 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 0,01265752 0,06496284 ! DNA catabolic process, endonucleolytic GO:0000737 38 24 1,000 0,01265752 0,06482665 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 1,000 0,01265752 0,06469103 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to corticosteroid stimulus GO:0031960 46 24 1,000 0,01265752 0,06455598 ! sex determination GO:0007530 48 24 1,000 0,01265752 0,06442149 ! regulation of viral reproduction GO:0050792 41 24 1,000 0,01265752 0,06428755 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 1,000 0,01265752 0,06415418 GO:0002708|positive regulation of lymphocyte mediated immunity, ! oogenesis GO:0048477 44 24 1,000 0,01265752 0,06402135 ! regulation of oxidoreductase activity GO:0051341 48 24 1,000 0,01265752 0,06388908 ! platelet activation GO:0030168 41 24 1,000 0,01265752 0,06375735 ! lung development GO:0030324 165 69 2,000 0,01336125 0,06716364 ! protein import into nucleus, translocation GO:0000060 51 25 1,000 0,01369397 0,06869478 ! positive regulation of fibroblast proliferation GO:0048146 48 25 1,000 0,01369397 0,06855402 ! myeloid leukocyte differentiation GO:0002573 46 25 1,000 0,01369397 0,06841382 ! regulation of transmembrane transport GO:0034762 39 25 1,000 0,01369397 0,0682742 ! leukocyte adhesion GO:0007159 55 25 1,000 0,01369397 0,06813515 ! vasculogenesis GO:0001570 49 25 1,000 0,01369397 0,06799667 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 0,01369397 0,06785874 ! receptor metabolic process GO:0043112 53 25 1,000 0,01369397 0,06772138 ! regulation of alpha-beta T cell activation GO:0046634 48 25 1,000 0,01369397 0,06758457 ! immunoglobulin production GO:0002377 62 25 1,000 0,01369397 0,06744831 GO:0002440|production of molecular mediator of immune response, ! leukocyte homeostasis GO:0001776 50 25 1,000 0,01369397 0,0673126 ! protein tetramerization GO:0051262 57 25 1,000 0,01369397 0,06717743 ! myelination GO:0042552 50 26 1,000 0,01476594 0,07229097 ! molting cycle process GO:0022404 52 26 1,000 0,01476594 0,07214639 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! regulation of smooth muscle contraction GO:0006940 48 26 1,000 0,01476594 0,07200239 ! multicellular organismal response to stress GO:0033555 61 26 1,000 0,01476594 0,07185896 ! vesicle docking during exocytosis GO:0006904 49 26 1,000 0,01476594 0,0717161 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 1,000 0,01476594 0,0715738 ! negative regulation of cell development GO:0010721 83 26 1,000 0,01476594 0,07143207 GO:0050768|negative regulation of neurogenesis, ! positive regulation of MAPKKK cascade GO:0043410 50 26 1,000 0,01476594 0,0712909 ! regulation of blood coagulation GO:0030193 46 26 1,000 0,01476594 0,07115029 ! blastocyst development GO:0001824 50 26 1,000 0,01476594 0,07101023 ! positive regulation of JUN kinase activity GO:0043507 59 26 1,000 0,01476594 0,07087072 ! respiratory tube development GO:0030323 171 72 2,000 0,01497426 0,07172964 ! actin filament organization GO:0007015 167 72 2,000 0,01497426 0,07158927 ! B cell activation GO:0042113 179 72 2,000 0,01497426 0,07144945 ! regulation of MAPKKK cascade GO:0043408 157 72 2,000 0,01497426 0,07131017 ! positive regulation of cell projection organization GO:0031346 66 27 1,000 0,01587289 0,07544253 ! insulin receptor signaling pathway GO:0008286 66 27 1,000 0,01587289 0,07529604 ! regulation of endothelial cell proliferation GO:0001936 60 27 1,000 0,01587289 0,07515012 ! response to starvation GO:0042594 47 27 1,000 0,01587289 0,07500476 ! response to toxin GO:0009636 49 27 1,000 0,01587289 0,07485997 ! regulation of chromosome organization GO:0033044 49 27 1,000 0,01587289 0,07471573 ! cellular response to nutrient levels GO:0031669 45 27 1,000 0,01587289 0,07457204 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 2,000 0,01610804 0,07553154 ! respiratory system development GO:0060541 175 74 2,000 0,01610804 0,07538685 ! phosphoinositide-mediated signaling GO:0048015 141 75 2,000 0,01669253 0,07797295 ! protein amino acid acylation GO:0043543 59 28 1,000 0,01701425 0,07932407 ! vesicle docking GO:0048278 55 28 1,000 0,01701425 0,07917298 ! dendrite development GO:0016358 67 28 1,000 0,01701425 0,07902246 ! base-excision repair GO:0006284 41 28 1,000 0,01701425 0,07887251 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 1,000 0,01701425 0,07872313 ! regulation of systemic arterial blood pressure GO:0003073 55 28 1,000 0,01701425 0,07857432 ! positive regulation of T cell differentiation GO:0045582 48 28 1,000 0,01701425 0,07842606 ! peptidyl-tyrosine modification GO:0018212 57 28 1,000 0,01701425 0,07827837 ! glutathione metabolic process GO:0006749 42 28 1,000 0,01701425 0,07813123 ! regulation of JUN kinase activity GO:0043506 67 28 1,000 0,01701425 0,07798464 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 2,000 0,01728879 0,07909459 ! cytosolic calcium ion homeostasis GO:0051480 149 77 2,000 0,01789683 0,08172327 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 1,000 0,01818949 0,0829047 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 1,000 0,01818949 0,08275031 ! response to organic cyclic substance GO:0014070 58 29 1,000 0,01818949 0,0825965 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 0,01818949 0,08244326 ! somitogenesis GO:0001756 52 29 1,000 0,01818949 0,08229059 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 0,01818949 0,08213848 ! positive regulation of lymphocyte activation GO:0051251 142 78 2,000 0,01851666 0,08346164 ! immune response-activating signal transduction GO:0002757 58 30 1,000 0,01939806 0,08727341 GO:0002764|immune response-regulating signal transduction, ! positive regulation of multicellular organism growth GO:0040018 55 30 1,000 0,01939806 0,08711299 ! tissue homeostasis GO:0001894 50 30 1,000 0,01939806 0,08695315 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 1,000 0,01939806 0,08679389 ! development of primary sexual characteristics GO:0045137 143 80 2,000 0,01979177 0,0883936 ! negative regulation of organelle organization GO:0010639 181 80 2,000 0,01979177 0,0882323 ! ovulation cycle process GO:0022602 55 31 1,000 0,02063944 0,09184362 ! peptide transport GO:0015833 60 31 1,000 0,02063944 0,09167663 ! male gonad development GO:0008584 56 31 1,000 0,02063944 0,09151025 ! ensheathment of neurons GO:0007272 64 31 1,000 0,02063944 0,09134447 GO:0008366|axon ensheathment, ! response to heat GO:0009408 54 31 1,000 0,02063944 0,09117929 ! positive regulation of immune effector process GO:0002699 78 31 1,000 0,02063944 0,09101471 ! protein import into nucleus GO:0006606 174 82 2,000 0,02111419 0,09294049 ! exocytosis GO:0006887 153 83 2,000 0,02179316 0,09575663 ! cellular lipid catabolic process GO:0044242 150 83 2,000 0,02179316 0,09558471 ! nuclear import GO:0051170 177 83 2,000 0,02179316 0,09541341 ! spindle organization GO:0007051 50 32 1,000 0,02191309 0,09576688 ! positive regulation of T cell proliferation GO:0042102 60 32 1,000 0,02191309 0,09559587 ! metanephros development GO:0001656 81 32 1,000 0,02191309 0,09542546 ! ovulation cycle GO:0042698 57 32 1,000 0,02191309 0,09525567 ! peripheral nervous system development GO:0007422 68 32 1,000 0,02191309 0,09508647 ! hindbrain development GO:0030902 65 32 1,000 0,02191309 0,09491788 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 1,000 0,02191309 0,09474989 ! myeloid leukocyte activation GO:0002274 53 32 1,000 0,02191309 0,09458248 ! regulation of pH GO:0006885 56 33 1,000 0,0232185 0,10004021 ! positive regulation of gene-specific transcription GO:0043193 70 33 1,000 0,0232185 0,09986409 ! positive regulation of cell activation GO:0050867 161 86 2,000 0,02390109 0,10261927 GO:0002696|positive regulation of leukocyte activation, ! response to hydrogen peroxide GO:0042542 56 34 1,000 0,02455515 0,10524253 ! post-embryonic development GO:0009791 76 34 1,000 0,02455515 0,10505821 ! membrane docking GO:0022406 69 35 1,000 0,02592254 0,11071461 ! protein localization in nucleus GO:0034504 192 89 2,000 0,02611551 0,11134415 ! positive regulation of protein modification process GO:0031401 156 90 2,000 0,02687728 0,11439235 ! positive regulation of cell development GO:0010720 85 36 1,000 0,02732015 0,11607498 ! negative regulation of hydrolase activity GO:0051346 66 36 1,000 0,02732015 0,11587346 ! ossification GO:0001503 205 91 2,000 0,02765085 0,11707285 ! bone development GO:0060348 206 92 2,000 0,02843621 0,12018971 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 1,000 0,02874748 0,12129552 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 1,000 0,02874748 0,12108639 ! tissue remodeling GO:0048771 78 37 1,000 0,02874748 0,12087798 ! female gonad development GO:0008585 71 37 1,000 0,02874748 0,12067028 ! hormone biosynthetic process GO:0042446 62 37 1,000 0,02874748 0,1204633 ! androgen receptor signaling pathway GO:0030521 81 37 1,000 0,02874748 0,12025703 ! regulation of cell morphogenesis GO:0022604 243 93 2,000 0,02923333 0,12208038 ! female pregnancy GO:0007565 166 94 2,000 0,0300422 0,12524419 ! regulation of membrane potential GO:0042391 179 94 2,000 0,0300422 0,12503083 ! meiosis I GO:0007127 74 38 1,000 0,03020406 0,12549068 ! embryonic skeletal system morphogenesis GO:0048704 68 38 1,000 0,03020406 0,12527763 ! cyclic nucleotide metabolic process GO:0009187 69 38 1,000 0,03020406 0,12506529 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 1,000 0,03020406 0,12485367 ! glycogen metabolic process GO:0005977 63 38 1,000 0,03020406 0,12464277 ! pigment metabolic process GO:0042440 87 38 1,000 0,03020406 0,12443258 ! cellular response to insulin stimulus GO:0032869 85 38 1,000 0,03020406 0,1242231 ! regulation of defense response GO:0031347 171 95 2,000 0,03086281 0,12671905 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 1,000 0,03168939 0,12989458 ! glucan metabolic process GO:0044042 64 39 1,000 0,03168939 0,12967701 GO:0006073|cellular glucan metabolic process, ! mammary gland development GO:0030879 93 40 1,000 0,03320298 0,13564362 ! development of primary female sexual characteristics GO:0046545 80 40 1,000 0,03320298 0,13541717 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 1,000 0,03320298 0,13519147 ! regulation of action potential in neuron GO:0019228 80 40 1,000 0,03320298 0,13496653 ! Rho protein signal transduction GO:0007266 88 40 1,000 0,03320298 0,13474233 ! establishment or maintenance of cell polarity GO:0007163 96 41 1,000 0,03474437 0,14076366 ! mesenchymal cell development GO:0014031 94 41 1,000 0,03474437 0,14053061 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 1,000 0,03474437 0,14029832 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,03522529 0,14200558 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,03522529 0,14177163 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,03522529 0,14153846 ! neuron fate determination GO:0048664 7 5 0,000 0,03522529 0,14130604 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03522529 0,14107439 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,03522529 0,1408435 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,03522529 0,14061337 ! polyol transport GO:0015791 12 5 0,000 0,03522529 0,14038398 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,03522529 0,14015534 ! response to superoxide GO:0000303 10 5 0,000 0,03522529 0,13992745 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,03522529 0,13970029 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,03522529 0,13947387 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,03522529 0,13924819 ! female meiosis GO:0007143 10 5 0,000 0,03522529 0,13902323 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,03522529 0,138799 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,03522529 0,13857549 ! hypothalamus development GO:0021854 9 5 0,000 0,03522529 0,1383527 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,03522529 0,13813063 ! cobalt ion transport GO:0006824 11 5 0,000 0,03522529 0,13790926 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,03522529 0,13768861 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,03522529 0,13746866 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,03522529 0,13724941 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,03522529 0,13703086 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,03522529 0,13681301 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,03522529 0,13659584 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03522529 0,13637937 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,03522529 0,13616358 ! transposition GO:0032196 9 5 0,000 0,03522529 0,13594847 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,03522529 0,13573404 ! negative chemotaxis GO:0050919 16 5 0,000 0,03522529 0,13552028 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,03522529 0,1353072 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,03522529 0,13509479 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,03522529 0,13488304 ! behavioral response to pain GO:0048266 10 5 0,000 0,03522529 0,13467196 ! clathrin coat assembly GO:0048268 15 5 0,000 0,03522529 0,13446153 ! Notch receptor processing GO:0007220 11 5 0,000 0,03522529 0,13425176 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03522529 0,13404265 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,03522529 0,13383418 ! micturition GO:0060073 9 5 0,000 0,03522529 0,13362637 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,03522529 0,13341919 ! copulation GO:0007620 9 5 0,000 0,03522529 0,13321266 ! glial cell fate commitment GO:0021781 14 5 0,000 0,03522529 0,13300677 ! protein maturation by protein folding GO:0022417 14 5 0,000 0,03522529 0,13280151 ! bioluminescence GO:0008218 9 5 0,000 0,03522529 0,13259689 ! spermidine metabolic process GO:0008216 7 5 0,000 0,03522529 0,13239289 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,03522529 0,13218952 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,03522529 0,13198678 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,03522529 0,13178466 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,03522529 0,13158315 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,03522529 0,13138226 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,03522529 0,13118198 ! grooming behavior GO:0007625 6 5 0,000 0,03522529 0,13098231 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,03522529 0,13078325 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,03522529 0,1305848 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,03522529 0,13038694 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03522529 0,13018968 ! response to protozoan GO:0001562 13 5 0,000 0,03522529 0,12999302 ! positive regulation of glycolysis GO:0045821 13 5 0,000 0,03522529 0,12979695 ! lymph vessel development GO:0001945 10 5 0,000 0,03522529 0,12960148 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,03522529 0,12940659 ! endochondral ossification GO:0001958 17 5 0,000 0,03522529 0,12921228 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,03522529 0,12901856 ! single strand break repair GO:0000012 8 5 0,000 0,03522529 0,12882542 ! parathyroid gland development GO:0060017 14 5 0,000 0,03522529 0,12863286 ! anagen GO:0042640 7 5 0,000 0,03522529 0,12844087 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,03522529 0,12824945 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,03522529 0,1280586 ! cytokine secretion GO:0050663 15 5 0,000 0,03522529 0,12786832 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,03522529 0,12767861 ! ceramide catabolic process GO:0046514 7 5 0,000 0,03522529 0,12748945 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,03522529 0,12730086 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,03522529 0,12711282 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,03522529 0,12692534 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,03522529 0,12673841 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,03522529 0,12655203 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,03522529 0,1263662 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,03522529 0,12618091 ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,03522529 0,12599616 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,03522529 0,12581196 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,03522529 0,12562829 ! valine metabolic process GO:0006573 12 5 0,000 0,03522529 0,12544516 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,03522529 0,12526256 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,03522529 0,1250805 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,03522529 0,12489896 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,03522529 0,12471794 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,03522529 0,12453745 ! polyol catabolic process GO:0046174 9 5 0,000 0,03522529 0,12435749 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,03522529 0,12417804 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,03522529 0,12399911 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,03522529 0,12382069 ! muscle cell migration GO:0014812 8 5 0,000 0,03522529 0,12364279 ! mitochondrial fission GO:0000266 8 5 0,000 0,03522529 0,1234654 ! sister chromatid cohesion GO:0007062 15 5 0,000 0,03522529 0,12328851 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,03522529 0,12311213 ! mRNA transcription GO:0009299 10 5 0,000 0,03522529 0,12293626 ! nerve growth factor processing GO:0032455 9 5 0,000 0,03522529 0,12276089 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,03522529 0,12258601 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,03522529 0,12241164 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 0,000 0,03522529 0,12223776 ! monocyte activation GO:0042117 10 5 0,000 0,03522529 0,12206437 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,03522529 0,12189147 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,03522529 0,12171907 ! response to food GO:0032094 6 5 0,000 0,03522529 0,12154715 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,03522529 0,12137571 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,03522529 0,12120476 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,03522529 0,12103429 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03522529 0,1208643 ! forebrain neuron development GO:0021884 13 5 0,000 0,03522529 0,12069478 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,03522529 0,12052574 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,03522529 0,12035718 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,03522529 0,12018908 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03522529 0,12002145 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,03522529 0,11985429 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,03522529 0,11968759 ! lipid glycosylation GO:0030259 7 5 0,000 0,03522529 0,11952136 ! nucleobase transport GO:0015851 6 5 0,000 0,03522529 0,11935559 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03522529 0,11919028 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,03522529 0,11902542 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,03522529 0,11886102 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,03522529 0,11869708 ! basic amino acid transport GO:0015802 12 5 0,000 0,03522529 0,11853358 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,03522529 0,11837054 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,03522529 0,11820794 ! actin nucleation GO:0045010 11 5 0,000 0,03522529 0,11804579 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03522529 0,11788408 ! depurination GO:0045007 5 5 0,000 0,03522529 0,11772282 ! depyrimidination GO:0045008 10 5 0,000 0,03522529 0,117562 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,03522529 0,11740161 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03522529 0,11724166 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,03522529 0,11708215 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,03522529 0,11692307 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,03522529 0,11676442 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03522529 0,11660621 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,03522529 0,11644842 ! activated T cell proliferation GO:0050798 16 5 0,000 0,03522529 0,11629105 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,03522529 0,11613412 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,03522529 0,1159776 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,03522529 0,11582151 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03522529 0,11566583 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,03522529 0,11551058 ! response to arsenic GO:0046685 11 5 0,000 0,03522529 0,11535574 ! mast cell degranulation GO:0043303 7 5 0,000 0,03522529 0,11520131 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,03522529 0,1150473 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,03522529 0,1148937 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,03522529 0,11474051 ! response to mercury ion GO:0046689 8 5 0,000 0,03522529 0,11458772 ! response to cadmium ion GO:0046686 7 5 0,000 0,03522529 0,11443535 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,03522529 0,11428337 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,03522529 0,1141318 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,03522529 0,11398064 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,03522529 0,11382987 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,03522529 0,1136795 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,03522529 0,11352953 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,03522529 0,11337995 ! decidualization GO:0046697 11 5 0,000 0,03522529 0,11323076 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,03522529 0,11308197 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,03522529 0,11293357 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,03522529 0,11278556 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,03522529 0,11263793 ! embryonic cleavage GO:0040016 6 5 0,000 0,03522529 0,11249069 ! peroxisome fission GO:0016559 5 5 0,000 0,03522529 0,11234384 ! histone demethylation GO:0016577 13 5 0,000 0,03522529 0,11219737 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,03522529 0,11205128 ! mitotic recombination GO:0006312 9 5 0,000 0,03522529 0,11190557 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,03522529 0,11176023 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,03522529 0,11161528 ! metaphase plate congression GO:0051310 7 5 0,000 0,03522529 0,1114707 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03522529 0,1113265 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,03522529 0,11118266 ! enteric nervous system development GO:0048484 8 5 0,000 0,03522529 0,1110392 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,03522529 0,11089611 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,03522529 0,11075339 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,03522529 0,11061103 ! muscle cell proliferation GO:0033002 12 5 0,000 0,03522529 0,11046904 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,03522529 0,11032741 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,03522529 0,11018615 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,03522529 0,11004524 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,03522529 0,1099047 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,03522529 0,10976452 ! cellular response to nutrient GO:0031670 8 5 0,000 0,03522529 0,10962469 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,03522529 0,10948522 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,03522529 0,1093461 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,03522529 0,10920734 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,03522529 0,10906892 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,03522529 0,10893086 ! response to redox state GO:0051775 6 5 0,000 0,03522529 0,10879315 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,03522529 0,10865578 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,03522529 0,10851877 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,03522529 0,10838209 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,03522529 0,10824576 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,03522529 0,10810977 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03522529 0,10797413 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,03522529 0,10783882 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03522529 0,10770386 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,03522529 0,10756923 ! striatum development GO:0021756 14 5 0,000 0,03522529 0,10743493 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,03522529 0,10730097 ! glial cell migration GO:0008347 10 5 0,000 0,03522529 0,10716735 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,03522529 0,10703406 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,03522529 0,10690109 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,03522529 0,10676846 ! T cell activation during immune response GO:0002286 9 5 0,000 0,03522529 0,10663616 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,03522529 0,10650418 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,03522529 0,10637253 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,03522529 0,10624121 ! neuroprotection GO:0043526 8 5 0,000 0,03522529 0,10611021 ! regulation of sensory perception GO:0051931 8 5 0,000 0,03522529 0,10597953 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,03522529 0,10584918 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,03522529 0,10571914 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,03522529 0,10558942 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,03522529 0,10546003 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,03522529 0,10533094 ! sequestering of calcium ion GO:0051208 7 5 0,000 0,03522529 0,10520218 ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,03522529 0,10507372 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,03522529 0,10494559 ! spindle assembly GO:0051225 6 5 0,000 0,03522529 0,10481776 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,03522529 0,10469024 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,03522529 0,10456304 ! protein palmitoylation GO:0018345 12 5 0,000 0,03522529 0,10443614 ! drug metabolic process GO:0017144 7 5 0,000 0,03522529 0,10430955 ! phospholipid scrambling GO:0017121 8 5 0,000 0,03522529 0,10418327 ! organ regeneration GO:0031100 7 5 0,000 0,03522529 0,10405729 ! carnitine metabolic process GO:0009437 8 5 0,000 0,03522529 0,10393162 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,03522529 0,10380625 ! regulation of leukocyte mediated immunity GO:0002703 84 42 1,000 0,03631307 0,10688293 ! dorsal/ventral pattern formation GO:0009953 75 42 1,000 0,03631307 0,10675431 ! cytokinesis GO:0000910 84 42 1,000 0,03631307 0,106626 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,03790863 0,11117742 GO:0090047|positive regulation of transcription regulator activity, ! epithelial cell differentiation GO:0030855 83 43 1,000 0,03790863 0,11104411 ! regulation of tube size GO:0035150 76 43 1,000 0,03790863 0,11091112 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 1,000 0,03790863 0,11077845 ! development of primary male sexual characteristics GO:0046546 80 43 1,000 0,03790863 0,1106461 ! segmentation GO:0035282 78 43 1,000 0,03790863 0,11051407 ! neuron migration GO:0001764 85 43 1,000 0,03790863 0,11038234 ! response to reactive oxygen species GO:0000302 75 44 1,000 0,03953059 0,11496812 ! energy reserve metabolic process GO:0006112 76 44 1,000 0,03953059 0,11483142 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,03953059 0,11469504 ! double-strand break repair GO:0006302 85 44 1,000 0,03953059 0,11455898 ! branching morphogenesis of a tube GO:0048754 102 45 1,000 0,04117848 0,11919315 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 1,000 0,04117848 0,1190521 ! female gamete generation GO:0007292 71 45 1,000 0,04117848 0,11891137 ! developmental growth GO:0048589 88 45 1,000 0,04117848 0,11877098 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,04212061 0,1213451 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,04212061 0,12120218 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,04212061 0,12105959 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,04212061 0,12091733 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,04212061 0,12077541 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,04212061 0,12063382 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,04212061 0,12049256 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,04212061 0,12035163 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,04212061 0,12021104 ! response to oxygen radical GO:0000305 11 6 0,000 0,04212061 0,12007077 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,04212061 0,11993082 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,04212061 0,11979121 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,04212061 0,11965192 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,04212061 0,11951295 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,04212061 0,1193743 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,04212061 0,11923598 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,04212061 0,11909797 ! forebrain regionalization GO:0021871 9 6 0,000 0,04212061 0,11896029 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,04212061 0,11882292 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,04212061 0,11868587 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,04212061 0,11854913 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,04212061 0,11841271 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 0,000 0,04212061 0,11827661 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,04212061 0,11814081 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,04212061 0,11800533 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,04212061 0,11787016 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,04212061 0,11773529 ! malate metabolic process GO:0006108 13 6 0,000 0,04212061 0,11760074 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,04212061 0,11746649 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,04212061 0,11733255 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,04212061 0,11719892 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,04212061 0,11706558 ! protein refolding GO:0042026 15 6 0,000 0,04212061 0,11693255 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,04212061 0,11679983 ! opsonization GO:0008228 8 6 0,000 0,04212061 0,1166674 ! mating behavior GO:0007617 7 6 0,000 0,04212061 0,11653527 ! erythrocyte maturation GO:0043249 8 6 0,000 0,04212061 0,11640345 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,04212061 0,11627192 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,04212061 0,11614069 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,04212061 0,11600975 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,04212061 0,11587911 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,04212061 0,11574876 ! response to interferon-gamma GO:0034341 16 6 0,000 0,04212061 0,1156187 ! toxin metabolic process GO:0009404 11 6 0,000 0,04212061 0,11548894 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,04212061 0,11535947 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,04212061 0,11523029 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,04212061 0,1151014 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! nuclear migration GO:0007097 13 6 0,000 0,04212061 0,11497279 ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,04212061 0,11484447 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,04212061 0,11471644 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,04212061 0,11458869 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,04212061 0,11446123 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,04212061 0,11433405 ! protein lipoylation GO:0009249 10 6 0,000 0,04212061 0,11420716 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,04212061 0,11408054 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,04212061 0,11395421 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,04212061 0,11382815 ! glutamate catabolic process GO:0006538 12 6 0,000 0,04212061 0,11370237 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,04212061 0,11357687 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,04212061 0,11345165 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,04212061 0,1133267 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,04212061 0,11320203 ! hyperosmotic response GO:0006972 10 6 0,000 0,04212061 0,11307763 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,04212061 0,11295351 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,04212061 0,11282966 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,04212061 0,11270608 ! urea metabolic process GO:0019627 7 6 0,000 0,04212061 0,11258277 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,04212061 0,11245972 ! neutrophil activation GO:0042119 7 6 0,000 0,04212061 0,11233695 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,04212061 0,11221445 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,04212061 0,11209221 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,04212061 0,11197024 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,04212061 0,11184853 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,04212061 0,11172709 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,04212061 0,11160591 ! neuron apoptosis GO:0051402 15 6 0,000 0,04212061 0,11148499 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,04212061 0,11136434 ! T cell mediated immunity GO:0002456 17 6 0,000 0,04212061 0,11124394 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,04212061 0,11112381 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,04212061 0,11100393 ! carnitine transport GO:0015879 10 6 0,000 0,04212061 0,11088432 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04212061 0,11076496 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,04212061 0,11064586 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,04212061 0,11052701 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,04212061 0,11040842 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,04212061 0,11029008 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,04212061 0,110172 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,04212061 0,11005417 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,04212061 0,10993659 ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,04212061 0,10981926 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,04212061 0,10970218 GO:0045686|negative regulation of glial cell differentiation, ! response to UV-C GO:0010225 14 6 0,000 0,04212061 0,10958535 ! astrocyte development GO:0014002 16 6 0,000 0,04212061 0,10946877 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,04212061 0,10935244 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,04212061 0,10923636 ! interaction with symbiont GO:0051702 14 6 0,000 0,04212061 0,10912052 ! regulation of dendrite development GO:0050773 16 6 0,000 0,04212061 0,10900492 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,04212061 0,10888957 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,04212061 0,10877447 ! response to copper ion GO:0046688 10 6 0,000 0,04212061 0,10865961 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,04212061 0,10854499 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,04212061 0,10843061 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04212061 0,10831647 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,04212061 0,10820257 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,04212061 0,10808892 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,04212061 0,1079755 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,04212061 0,10786231 ! hair follicle maturation GO:0048820 8 6 0,000 0,04212061 0,10774937 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,04212061 0,10763666 ! Schwann cell development GO:0014044 15 6 0,000 0,04212061 0,10752419 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,04212061 0,10741195 ! response to pheromone GO:0019236 6 6 0,000 0,04212061 0,10729995 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,04212061 0,10718817 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,04212061 0,10707664 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,04212061 0,10696533 ! subpallium development GO:0021544 15 6 0,000 0,04212061 0,10685425 ! neural tube patterning GO:0021532 8 6 0,000 0,04212061 0,10674341 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,04212061 0,1066328 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,04212061 0,10652241 ! maintenance of organ identity GO:0048496 9 6 0,000 0,04212061 0,10641225 ! G2 phase GO:0051319 16 6 0,000 0,04212061 0,10630232 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,04212061 0,10619262 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,04212061 0,10608314 ! oxygen homeostasis GO:0032364 10 6 0,000 0,04212061 0,10597389 ! establishment of planar polarity GO:0001736 7 6 0,000 0,04212061 0,10586486 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,04212061 0,10575606 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,04212061 0,10564748 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,04212061 0,10553913 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,04212061 0,10543099 ! receptor internalization GO:0031623 11 6 0,000 0,04212061 0,10532308 ! positive regulation of pseudopodium assembly GO:0031274 15 6 0,000 0,04212061 0,10521539 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 9 6 0,000 0,04212061 0,10510791 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,04212061 0,10500066 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04212061 0,10489363 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,04212061 0,10478681 ! protein deubiquitination GO:0016579 16 6 0,000 0,04212061 0,10468021 ! protein destabilization GO:0031648 9 6 0,000 0,04212061 0,10457383 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,04212061 0,10446766 ! negative regulation of osteoblast differentiation GO:0045668 17 6 0,000 0,04212061 0,10436171 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,04212061 0,10425598 ! regulation of viral transcription GO:0046782 11 6 0,000 0,04212061 0,10415045 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,04212061 0,10404514 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,04212061 0,10394005 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,04212061 0,10383516 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,04212061 0,10373049 ! determination of adult lifespan GO:0008340 17 6 0,000 0,04212061 0,10362603 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,04212061 0,10352178 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,04212061 0,10341774 ! neural plate development GO:0001840 9 6 0,000 0,04212061 0,1033139 ! catecholamine transport GO:0051937 9 6 0,000 0,04212061 0,10321028 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,04212061 0,10310686 ! sensory cilium assembly GO:0035058 10 6 0,000 0,04212061 0,10300365 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,04212061 0,10290065 ! maternal placenta development GO:0001893 12 6 0,000 0,04212061 0,10279785 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,04212061 0,10269526 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,04212061 0,10259287 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,04212061 0,10249068 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,04212061 0,1023887 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,04212061 0,10228693 ! cell growth GO:0016049 90 46 1,000 0,04285186 0,10395938 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,04285186 0,10385624 ! regulation of JNK cascade GO:0046328 104 47 1,000 0,04455028 0,10786555 ! response to insulin stimulus GO:0032868 98 47 1,000 0,04455028 0,10775875 ! positive regulation of cell cycle GO:0045787 96 48 1,000 0,04627331 0,11181572 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 1,000 0,04627331 0,11170523 ! endosome transport GO:0016197 127 48 1,000 0,04627331 0,11159496 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,04627331 0,11148491 ! regulation of adaptive immune response GO:0002819 92 48 1,000 0,04627331 0,11137507 ! JNK cascade GO:0007254 106 49 1,000 0,0480205 0,11546662 ! tRNA transcription GO:0009304 17 7 0,000 0,04896684 0,11762634 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,04896684 0,1175108 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,04896684 0,11739548 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,04896684 0,11728038 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,04896684 0,11716551 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,04896684 0,11705087 ! sleep GO:0030431 16 7 0,000 0,04896684 0,11693645 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,04896684 0,11682226 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,04896684 0,11670828 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,04896684 0,11659453 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,04896684 0,116481 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04896684 0,11636769 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,04896684 0,11625461 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,04896684 0,11614174 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04896684 0,11602909 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,04896684 0,11591666 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,04896684 0,11580444 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,04896684 0,11569245 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,04896684 0,11558067 ! glycolipid transport GO:0046836 11 7 0,000 0,04896684 0,1154691 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,04896684 0,11535775 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,04896684 0,11524662 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,04896684 0,1151357 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,04896684 0,11502499 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,04896684 0,1149145 ! pericardium development GO:0060039 16 7 0,000 0,04896684 0,11480421 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 0,000 0,04896684 0,11469414 GO:0031958|corticosteroid receptor signaling pathway, ! fibril organization GO:0043206 17 7 0,000 0,04896684 0,11458428 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,04896684 0,11447463 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,04896684 0,11436519 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,04896684 0,11425596 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,04896684 0,11414694 ! lipoprotein transport GO:0042953 14 7 0,000 0,04896684 0,11403812 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,04896684 0,11392951 ! rhythmic behavior GO:0007622 17 7 0,000 0,04896684 0,11382111 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,04896684 0,11371292 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,04896684 0,11360493 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,04896684 0,11349714 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,04896684 0,11338956 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,04896684 0,11328219 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,04896684 0,11317501 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,04896684 0,11306804 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,04896684 0,11296128 ! mechanosensory behavior GO:0007638 16 7 0,000 0,04896684 0,11285471 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,04896684 0,11274834 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,04896684 0,11264218 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04896684 0,11253621 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04896684 0,11243044 ! spinal cord patterning GO:0021511 14 7 0,000 0,04896684 0,11232487 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,04896684 0,1122195 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,04896684 0,11211433 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,04896684 0,11200935 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,04896684 0,11190457 ! adrenal gland development GO:0030325 17 7 0,000 0,04896684 0,11179999 ! cysteine metabolic process GO:0006534 13 7 0,000 0,04896684 0,1116956 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,04896684 0,11159141 ! ovulation GO:0030728 10 7 0,000 0,04896684 0,11148741 ! adenohypophysis development GO:0021984 11 7 0,000 0,04896684 0,1113836 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,04896684 0,11127999 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,04896684 0,11117657 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,04896684 0,11107334 ! microtubule nucleation GO:0007020 21 7 0,000 0,04896684 0,11097031 ! proline biosynthetic process GO:0006561 10 7 0,000 0,04896684 0,11086746 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,04896684 0,11076481 ! thyroid hormone generation GO:0006590 13 7 0,000 0,04896684 0,11066234 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,04896684 0,11056006 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,04896684 0,11045798 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,04896684 0,11035608 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,04896684 0,11025437 ! galactose metabolic process GO:0006012 13 7 0,000 0,04896684 0,11015285 ! vesicle fusion GO:0006906 20 7 0,000 0,04896684 0,11005151 ! response to dietary excess GO:0002021 8 7 0,000 0,04896684 0,10995036 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,04896684 0,10984939 ! intracellular pH reduction GO:0051452 13 7 0,000 0,04896684 0,10974861 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,04896684 0,10964802 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,04896684 0,10954761 ! nucleoside transport GO:0015858 11 7 0,000 0,04896684 0,10944738 ! nucleoside salvage GO:0043174 11 7 0,000 0,04896684 0,10934734 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,04896684 0,10924748 ! male sex determination GO:0030238 15 7 0,000 0,04896684 0,1091478 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,04896684 0,1090483 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,04896684 0,10894899 ! parturition GO:0007567 16 7 0,000 0,04896684 0,10884985 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,04896684 0,1087509 ! rRNA modification GO:0000154 14 7 0,000 0,04896684 0,10865213 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,04896684 0,10855353 ! spindle checkpoint GO:0031577 16 7 0,000 0,04896684 0,10845511 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,04896684 0,10835688 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,04896684 0,10825881 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,04896684 0,10816093 ! negative regulation of peptide secretion GO:0002792 10 7 0,000 0,04896684 0,10806323 GO:0046676|negative regulation of insulin secretion, ! centrosome duplication GO:0051298 14 7 0,000 0,04896684 0,1079657 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,04896684 0,10786834 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,04896684 0,10777116 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,04896684 0,10767416 ! eating behavior GO:0042755 8 7 0,000 0,04896684 0,10757733 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,04896684 0,10748067 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,04896684 0,10738419 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,04896684 0,10728788 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,04896684 0,10719175 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,04896684 0,10709578 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,04896684 0,10699999 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,04896684 0,10690437 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,04896684 0,10680892 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,04896684 0,10671364 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,04896684 0,10661853 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,04896684 0,10652359 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,04896684 0,10642882 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,04896684 0,10633421 ! histone ubiquitination GO:0016574 9 7 0,000 0,04896684 0,10623978 ! regulation of meiosis GO:0040020 12 7 0,000 0,04896684 0,10614551 GO:0051445|regulation of meiotic cell cycle, ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,04896684 0,10605141 ! regulation of lipid transport GO:0032368 14 7 0,000 0,04896684 0,10595748 ! membrane to membrane docking GO:0022614 14 7 0,000 0,04896684 0,10586371 ! transcription termination GO:0006353 14 7 0,000 0,04896684 0,10577011 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,04896684 0,10567667 ! anaphase GO:0051322 18 7 0,000 0,04896684 0,1055834 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,04896684 0,10549029 ! axonal fasciculation GO:0007413 19 7 0,000 0,04896684 0,10539735 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,04896684 0,10530457 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,04896684 0,10521195 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,04896684 0,1051195 GO:0015991|ATP hydrolysis coupled proton transport, ! diuresis GO:0030146 12 7 0,000 0,04896684 0,10502721 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,04896684 0,10493508 ! thiamin metabolic process GO:0006772 7 7 0,000 0,04896684 0,10484311 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04896684 0,1047513 ! antibiotic transport GO:0042891 9 7 0,000 0,04896684 0,10465966 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,04896684 0,10456817 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,04896684 0,10447685 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,04896684 0,10438568 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,04896684 0,10429467 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,04896684 0,10420382 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,04896684 0,10411313 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,04896684 0,1040226 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,04896684 0,10393222 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,04896684 0,10384201 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,04896684 0,10375194 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,04896684 0,10366204 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,04896684 0,10357229 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,04896684 0,10348269 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,04896684 0,10339325 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,04896684 0,10330396 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,04896684 0,10321483 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,04896684 0,10312585 ! muscle adaptation GO:0043500 13 7 0,000 0,04896684 0,10303703 ! embryonic heart tube development GO:0035050 14 7 0,000 0,04896684 0,10294836 ! retina homeostasis GO:0001895 12 7 0,000 0,04896684 0,10285984 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,04896684 0,10277147 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,04896684 0,10268325 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,04896684 0,10259519 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,04896684 0,10250728 ! regulation of action potential GO:0001508 102 50 1,000 0,04979143 0,10414424 ! regulation of ossification GO:0030278 123 50 1,000 0,04979143 0,10405515 ! regulation of cell projection organization GO:0031344 135 51 1,000 0,05158568 0,10771266 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 1,000 0,05158568 0,10762067 ! response to temperature stimulus GO:0009266 84 51 1,000 0,05158568 0,10752885 ! positive regulation of binding GO:0051099 88 52 1,000 0,05340281 0,11122171 ! response to estrogen stimulus GO:0043627 98 52 1,000 0,05340281 0,11112697 ! Notch signaling pathway GO:0007219 111 52 1,000 0,05340281 0,1110324 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,05340281 0,11093798 ! DNA-dependent DNA replication GO:0006261 82 52 1,000 0,05340281 0,11084373 ! histone modification GO:0016570 104 52 1,000 0,05340281 0,11074963 ! morphogenesis of a branching structure GO:0001763 116 52 1,000 0,05340281 0,1106557 ! positive regulation of growth GO:0045927 96 53 1,000 0,05524242 0,11437053 ! vesicle organization GO:0016050 127 53 1,000 0,05524242 0,11427369 ! synapse organization GO:0050808 102 53 1,000 0,05524242 0,11417701 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,05576433 0,11515829 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,05576433 0,11506103 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,05576433 0,11496393 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,05576433 0,114867 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,05576433 0,11477023 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,05576433 0,11467362 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,05576433 0,11457717 ! male meiosis GO:0007140 9 8 0,000 0,05576433 0,11448089 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,05576433 0,11438477 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,05576433 0,11428881 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,05576433 0,11419301 ! meiotic prophase I GO:0007128 14 8 0,000 0,05576433 0,11409737 ! response to zinc ion GO:0010043 12 8 0,000 0,05576433 0,11400189 ! regulation of lipid kinase activity GO:0043550 17 8 0,000 0,05576433 0,11390657 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,05576433 0,11381141 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,05576433 0,11371641 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,05576433 0,11362157 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,05576433 0,11352688 ! signal peptide processing GO:0006465 12 8 0,000 0,05576433 0,11343236 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,05576433 0,11333799 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,05576433 0,11324377 ! succinate metabolic process GO:0006105 17 8 0,000 0,05576433 0,11314972 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,05576433 0,11305582 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,05576433 0,11296207 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,05576433 0,11286848 ! estrogen metabolic process GO:0008210 17 8 0,000 0,05576433 0,11277505 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,05576433 0,11268177 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,05576433 0,11258864 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,05576433 0,11249567 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05576433 0,11240285 ! reflex GO:0060004 17 8 0,000 0,05576433 0,11231019 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,05576433 0,11221768 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,05576433 0,11212532 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,05576433 0,11203311 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,05576433 0,11194105 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,05576433 0,11184915 ! astrocyte differentiation GO:0048708 19 8 0,000 0,05576433 0,11175739 ! histidine catabolic process GO:0006548 10 8 0,000 0,05576433 0,11166579 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,05576433 0,11157433 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,05576433 0,11148303 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,05576433 0,11139187 GO:0006559|L-phenylalanine catabolic process, ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,05576433 0,11130087 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,05576433 0,11121001 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,05576433 0,1111193 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,05576433 0,11102874 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,05576433 0,11093832 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,05576433 0,11084806 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,05576433 0,11075793 ! purine salvage GO:0043101 12 8 0,000 0,05576433 0,11066796 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,05576433 0,11057813 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,05576433 0,11048845 ! osteoblast development GO:0002076 17 8 0,000 0,05576433 0,11039891 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,05576433 0,11030952 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,05576433 0,11022027 ! Schwann cell differentiation GO:0014037 21 8 0,000 0,05576433 0,11013117 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,05576433 0,11004221 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,05576433 0,1099534 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,05576433 0,10986473 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,05576433 0,1097762 ! intermediate filament organization GO:0045109 12 8 0,000 0,05576433 0,10968781 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,05576433 0,10959957 ! cellular extravasation GO:0045123 13 8 0,000 0,05576433 0,10951146 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,05576433 0,1094235 ! response to antibiotic GO:0046677 11 8 0,000 0,05576433 0,10933568 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,05576433 0,109248 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,05576433 0,10916046 ! DNA topological change GO:0006265 12 8 0,000 0,05576433 0,10907307 ! response to tropane GO:0014073 15 8 0,000 0,05576433 0,10898581 GO:0042220|response to cocaine, ! melanosome transport GO:0032402 13 8 0,000 0,05576433 0,10889869 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,05576433 0,10881171 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,05576433 0,10872487 ! mast cell activation GO:0045576 14 8 0,000 0,05576433 0,10863817 ! multicellular organismal aging GO:0010259 20 8 0,000 0,05576433 0,1085516 ! gas homeostasis GO:0033483 14 8 0,000 0,05576433 0,10846517 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,05576433 0,10837889 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,05576433 0,10829273 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,05576433 0,10820672 ! nucleosome disassembly GO:0006337 14 8 0,000 0,05576433 0,10812084 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,05576433 0,1080351 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! establishment of nucleus localization GO:0040023 18 8 0,000 0,05576433 0,10794949 ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,05576433 0,10786402 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,05576433 0,10777869 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,05576433 0,10769349 ! intracellular lipid transport GO:0032365 16 8 0,000 0,05576433 0,10760842 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,05576433 0,10752349 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of respiratory burst GO:0060263 12 8 0,000 0,05576433 0,10743869 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,05576433 0,10735403 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,05576433 0,1072695 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,05576433 0,1071851 ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,05576433 0,10710083 ! hormone catabolic process GO:0042447 17 8 0,000 0,05576433 0,1070167 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,05576433 0,1069327 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,05576433 0,10684883 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,05576433 0,10676509 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,05576433 0,10668149 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,05576433 0,10659801 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,05576433 0,10651467 ! adult feeding behavior GO:0008343 10 8 0,000 0,05576433 0,10643145 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,05576433 0,10634837 ! ATP catabolic process GO:0006200 11 8 0,000 0,05576433 0,10626541 ! blastocyst growth GO:0001832 19 8 0,000 0,05576433 0,10618259 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,05576433 0,10609989 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,05576433 0,10601732 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,05576433 0,10593488 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,05576433 0,10585257 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,05576433 0,10577039 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,05576433 0,10568833 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,05576433 0,1056064 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,05576433 0,1055246 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,05576433 0,10544293 GO:0006043|glucosamine catabolic process, ! regulation of growth hormone secretion GO:0060123 16 8 0,000 0,05576433 0,10536138 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,05576433 0,10527995 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,05576433 0,10519866 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,05576433 0,10511748 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,05576433 0,10503644 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,05576433 0,10495552 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,05576433 0,10487472 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,05710409 0,10731177 GO:0010863|positive regulation of phospholipase C activity, ! embryonic skeletal system development GO:0048706 101 54 1,000 0,05710409 0,10722928 ! covalent chromatin modification GO:0016569 115 54 1,000 0,05710409 0,10714692 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,05898742 0,11059576 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 1,000 0,05898742 0,11051094 ! regulation of multicellular organism growth GO:0040014 90 55 1,000 0,05898742 0,11042626 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,06089201 0,11390442 ! axon extension GO:0048675 16 9 0,000 0,06251343 0,11684797 ! positive regulation of glucose metabolic process GO:0010907 18 9 0,000 0,06251343 0,11675864 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,06251343 0,11666944 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,06251343 0,11658038 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,06251343 0,11649146 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,06251343 0,11640267 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,06251343 0,11631401 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,06251343 0,11622549 ! reproductive behavior GO:0019098 22 9 0,000 0,06251343 0,11613711 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,06251343 0,11604886 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 0,000 0,06251343 0,11596074 GO:0010469|regulation of receptor activity, ! Golgi to endosome transport GO:0006895 25 9 0,000 0,06251343 0,11587276 ! UTP metabolic process GO:0046051 10 9 0,000 0,06251343 0,11578491 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,06251343 0,1156972 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,06251343 0,11560961 ! artery development GO:0060840 25 9 0,000 0,06251343 0,11552216 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,06251343 0,11543485 ! regulation of glycolysis GO:0006110 20 9 0,000 0,06251343 0,11534766 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,06251343 0,1152606 ! equilibrioception GO:0050957 20 9 0,000 0,06251343 0,11517368 ! chemosensory behavior GO:0007635 21 9 0,000 0,06251343 0,11508689 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,06251343 0,11500023 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,06251343 0,11491369 ! leukocyte degranulation GO:0043299 16 9 0,000 0,06251343 0,11482729 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,06251343 0,11474102 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,06251343 0,11465488 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,06251343 0,11456887 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,06251343 0,11448298 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,06251343 0,11439723 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,06251343 0,1143116 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,06251343 0,1142261 ! protein targeting to ER GO:0045047 25 9 0,000 0,06251343 0,11414073 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,06251343 0,11405549 ! nerve growth factor receptor signaling pathway GO:0048011 20 9 0,000 0,06251343 0,11397037 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,06251343 0,11388538 ! glycine catabolic process GO:0006546 15 9 0,000 0,06251343 0,11380052 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,06251343 0,11371579 ! endosome organization GO:0007032 20 9 0,000 0,06251343 0,11363118 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,06251343 0,11354669 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,06251343 0,11346233 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,06251343 0,1133781 ! mannose metabolic process GO:0006013 13 9 0,000 0,06251343 0,11329399 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,06251343 0,11321001 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,06251343 0,11312615 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,06251343 0,11304241 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,06251343 0,1129588 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,06251343 0,11287531 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,06251343 0,11279195 ! retinol metabolic process GO:0042572 20 9 0,000 0,06251343 0,11270871 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,06251343 0,11262559 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,06251343 0,11254259 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,06251343 0,11245972 ! macrophage differentiation GO:0030225 15 9 0,000 0,06251343 0,11237697 ! oligodendrocyte development GO:0014003 11 9 0,000 0,06251343 0,11229434 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 0,000 0,06251343 0,11221183 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,06251343 0,11212944 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,06251343 0,11204718 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,06251343 0,11196503 ! response to amine stimulus GO:0014075 13 9 0,000 0,06251343 0,111883 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,06251343 0,1118011 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,06251343 0,11171931 ! erythrocyte development GO:0048821 17 9 0,000 0,06251343 0,11163765 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,06251343 0,1115561 ! renal water homeostasis GO:0003091 15 9 0,000 0,06251343 0,11147467 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,06251343 0,11139336 ! icosanoid secretion GO:0032309 15 9 0,000 0,06251343 0,11131217 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,06251343 0,1112311 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,06251343 0,11115015 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,06251343 0,11106931 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,06251343 0,11098859 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,06251343 0,11090799 ! sterol catabolic process GO:0016127 14 9 0,000 0,06251343 0,1108275 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,06251343 0,11074714 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,06251343 0,11066688 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,06251343 0,11058675 ! S phase GO:0051320 10 9 0,000 0,06251343 0,11050673 GO:0000084|S phase of mitotic cell cycle, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,06251343 0,11042683 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,06251343 0,11034704 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,06251343 0,11026736 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,06251343 0,11018781 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,06251343 0,11010836 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,06251343 0,11002903 ! purine base metabolic process GO:0006144 25 9 0,000 0,06251343 0,10994982 ! pigment granule transport GO:0051904 17 9 0,000 0,06251343 0,10987072 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,06251343 0,10979173 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,06251343 0,10971286 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,06251343 0,1096341 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,06251343 0,10955545 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,06251343 0,10947692 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,06251343 0,1093985 ! mitochondrion localization GO:0051646 18 9 0,000 0,06251343 0,10932019 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,06281745 0,10977327 ! nucleotide-excision repair GO:0006289 91 57 1,000 0,06281745 0,10969481 ! cellular polysaccharide metabolic process GO:0044264 93 58 1,000 0,06476336 0,11301207 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,06476336 0,1129314 ! nuclear export GO:0051168 110 59 1,000 0,06672935 0,1162766 ! establishment of organelle localization GO:0051656 122 59 1,000 0,06672935 0,11619373 ! DNA catabolic process GO:0006308 94 60 1,000 0,06871503 0,11956611 ! regulation of endocytosis GO:0030100 104 60 1,000 0,06871503 0,11948101 ! kidney development GO:0001822 133 60 1,000 0,06871503 0,11939603 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,06921447 0,12017836 ! regulation of developmental growth GO:0048638 16 10 0,000 0,06921447 0,120093 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,06921447 0,12000777 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,06921447 0,11992266 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,06921447 0,11983767 ! associative learning GO:0008306 21 10 0,000 0,06921447 0,1197528 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,06921447 0,11966805 ! phosphate transport GO:0006817 24 10 0,000 0,06921447 0,11958342 ! cell volume homeostasis GO:0006884 17 10 0,000 0,06921447 0,1194989 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,06921447 0,11941451 ! CTP metabolic process GO:0046036 11 10 0,000 0,06921447 0,11933024 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,06921447 0,11924609 ! GTP metabolic process GO:0046039 11 10 0,000 0,06921447 0,11916205 ! elastic fiber assembly GO:0048251 17 10 0,000 0,06921447 0,11907813 ! social behavior GO:0035176 29 10 0,000 0,06921447 0,11899434 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,06921447 0,11891065 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,06921447 0,11882709 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,06921447 0,11874364 ! androgen metabolic process GO:0008209 17 10 0,000 0,06921447 0,11866032 ! phospholipid efflux GO:0033700 19 10 0,000 0,06921447 0,1185771 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,06921447 0,11849401 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,06921447 0,11841103 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,06921447 0,11832817 ! pathogenesis GO:0009405 17 10 0,000 0,06921447 0,11824542 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06921447 0,11816279 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,06921447 0,11808027 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,06921447 0,11799787 ! endoderm development GO:0007492 18 10 0,000 0,06921447 0,11791559 ! positive regulation of survival gene product expression GO:0045885 26 10 0,000 0,06921447 0,11783341 ! arginine catabolic process GO:0006527 17 10 0,000 0,06921447 0,11775136 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,06921447 0,11766942 ! proline metabolic process GO:0006560 13 10 0,000 0,06921447 0,11758759 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,06921447 0,11750587 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,06921447 0,11742427 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,06921447 0,11734278 ! V(D)J recombination GO:0033151 34 10 0,000 0,06921447 0,11726141 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,06921447 0,11718015 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,06921447 0,117099 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,06921447 0,11701796 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,06921447 0,11693703 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,06921447 0,11685622 ! multicellular organism growth GO:0035264 19 10 0,000 0,06921447 0,11677552 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,06921447 0,11669493 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,06921447 0,11661445 ! ruffle organization GO:0031529 17 10 0,000 0,06921447 0,11653408 ! epithelial cell development GO:0002064 21 10 0,000 0,06921447 0,11645382 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,06921447 0,11637368 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,06921447 0,11629364 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,06921447 0,11621371 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,06921447 0,11613389 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,06921447 0,11605419 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,06921447 0,11597459 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 13 10 0,000 0,06921447 0,1158951 ! protein heterooligomerization GO:0051291 17 10 0,000 0,06921447 0,11581572 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,06921447 0,11573645 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,06921447 0,11565728 ! segment specification GO:0007379 15 10 0,000 0,06921447 0,11557823 ! positive regulation of phagocytosis GO:0050766 14 10 0,000 0,06921447 0,11549928 ! blastoderm segmentation GO:0007350 19 10 0,000 0,06921447 0,11542044 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,06921447 0,11534171 ! DNA ligation GO:0006266 18 10 0,000 0,06921447 0,11526309 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,06921447 0,11518457 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,06921447 0,11510616 ! melanosome localization GO:0032400 16 10 0,000 0,06921447 0,11502786 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,06921447 0,11494966 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,06921447 0,11487157 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,06921447 0,11479358 ! induction of an organ GO:0001759 17 10 0,000 0,06921447 0,11471571 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,06921447 0,11463793 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,06921447 0,11456026 ! protein sumoylation GO:0016925 17 10 0,000 0,06921447 0,1144827 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,06921447 0,11440524 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,06921447 0,11432789 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06921447 0,11425064 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,06921447 0,1141735 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,06921447 0,11409646 ! salivary gland development GO:0007431 28 10 0,000 0,06921447 0,11401952 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,06921447 0,11394269 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,06921447 0,11386596 ! midbrain development GO:0030901 14 10 0,000 0,06921447 0,11378933 ! musculoskeletal movement GO:0050881 16 10 0,000 0,06921447 0,11371281 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,06921447 0,11363639 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,06921447 0,11356007 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,06921447 0,11348386 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,06921447 0,11340775 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,06921447 0,11333174 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,06921447 0,11325583 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,06921447 0,11318002 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,06921447 0,11310431 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 0,000 0,06921447 0,11302871 GO:0043470|regulation of carbohydrate catabolic process, ! detection of calcium ion GO:0005513 24 10 0,000 0,06921447 0,11295321 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,06921447 0,1128778 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,06921447 0,1128025 ! cerebellar cortex development GO:0021695 16 10 0,000 0,06921447 0,1127273 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,06921447 0,1126522 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,06921447 0,1125772 ! regulation of mitosis GO:0007088 112 63 1,000 0,07478647 0,12155911 GO:0051783|regulation of nuclear division, ! respiratory burst GO:0045730 17 11 0,000 0,0758678 0,12323474 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,0758678 0,12315285 ! neuron fate specification GO:0048665 18 11 0,000 0,0758678 0,12307108 ! telencephalon cell migration GO:0022029 23 11 0,000 0,0758678 0,12298941 ! cortical actin cytoskeleton organization GO:0030866 29 11 0,000 0,0758678 0,12290785 ! thyroid gland development GO:0030878 26 11 0,000 0,0758678 0,1228264 ! synapsis GO:0007129 14 11 0,000 0,0758678 0,12274506 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,0758678 0,12266383 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,0758678 0,1225827 ! response to pain GO:0048265 27 11 0,000 0,0758678 0,12250168 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,0758678 0,12242077 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,0758678 0,12233996 ! bone resorption GO:0045453 16 11 0,000 0,0758678 0,12225926 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,0758678 0,12217867 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,0758678 0,12209818 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,0758678 0,1220178 ! melanocyte differentiation GO:0030318 20 11 0,000 0,0758678 0,12193753 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,0758678 0,12185736 GO:0009075|histidine family amino acid metabolic process, ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,0758678 0,12177729 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,0758678 0,12169734 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,0758678 0,12161748 ! UV protection GO:0009650 20 11 0,000 0,0758678 0,12153773 ! adult heart development GO:0007512 16 11 0,000 0,0758678 0,12145809 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,0758678 0,12137855 ! macroautophagy GO:0016236 19 11 0,000 0,0758678 0,12129911 ! temperature homeostasis GO:0001659 18 11 0,000 0,0758678 0,12121978 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,0758678 0,12114055 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,0758678 0,12106143 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,0758678 0,1209824 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,0758678 0,12090348 ! regulation of organ growth GO:0046620 14 11 0,000 0,0758678 0,12082467 ! pigment granule localization GO:0051875 20 11 0,000 0,0758678 0,12074596 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,0758678 0,12066735 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,0758678 0,12058884 ! embryonic axis specification GO:0000578 19 11 0,000 0,0758678 0,12051043 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,0758678 0,12043213 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,0758678 0,12035392 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,0758678 0,12027582 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,0758678 0,12019782 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,0758678 0,12011992 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,0758678 0,12004213 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,0758678 0,11996443 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,0758678 0,11988683 ! prophase GO:0051324 17 11 0,000 0,0758678 0,11980934 ! neuroblast proliferation GO:0007405 25 11 0,000 0,0758678 0,11973194 ! nucleosome positioning GO:0016584 15 11 0,000 0,0758678 0,11965464 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,0758678 0,11957745 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,0758678 0,11950035 ! apical protein localization GO:0045176 18 11 0,000 0,0758678 0,11942335 ! acid secretion GO:0046717 20 11 0,000 0,0758678 0,11934645 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,0758678 0,11926965 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,0758678 0,11919295 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,0758678 0,11911635 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,0758678 0,11903985 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,0758678 0,11896344 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cholesterol efflux GO:0033344 21 11 0,000 0,0758678 0,11888713 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,0758678 0,11881092 ! germ cell migration GO:0008354 26 11 0,000 0,0758678 0,11873481 ! embryonic gut development GO:0048566 19 11 0,000 0,0758678 0,1186588 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,0758678 0,11858288 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,0758678 0,11850706 ! activation of innate immune response GO:0002218 16 11 0,000 0,0758678 0,11843134 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,0758678 0,11835571 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,0758678 0,11828018 ! lysogeny GO:0030069 22 11 0,000 0,0758678 0,11820475 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,0758678 0,11812941 ! sequestering of metal ion GO:0051238 15 11 0,000 0,0758678 0,11805417 ! regulation of embryonic development GO:0045995 35 11 0,000 0,0758678 0,11797902 ! nucleus localization GO:0051647 22 11 0,000 0,0758678 0,11790397 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 1,000 0,07892573 0,12257823 ! multicellular organism reproduction GO:0032504 123 65 1,000 0,07892573 0,12250035 GO:0048609|reproductive process in a multicellular organism, ! nucleoside monophosphate metabolic process GO:0009123 117 65 1,000 0,07892573 0,12242257 ! ear development GO:0043583 114 66 1,000 0,08102176 0,12559401 ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,08102176 0,12551437 ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,08247376 0,12768276 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,08247376 0,1276019 ! positive regulation of cellular catabolic process GO:0031331 34 12 0,000 0,08247376 0,12752114 ! cortical cytoskeleton organization GO:0030865 30 12 0,000 0,08247376 0,12744048 ! virus-host interaction GO:0019048 30 12 0,000 0,08247376 0,12735993 ! mating GO:0007618 17 12 0,000 0,08247376 0,12727947 ! protein complex disassembly GO:0043241 28 12 0,000 0,08247376 0,12719912 GO:0043624|cellular protein complex disassembly, ! hippocampus development GO:0021766 29 12 0,000 0,08247376 0,12711887 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,08247376 0,12703872 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,08247376 0,12695867 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,08247376 0,12687872 ! ventral spinal cord development GO:0021517 25 12 0,000 0,08247376 0,12679887 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,08247376 0,12671912 ! drug transport GO:0015893 16 12 0,000 0,08247376 0,12663947 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,08247376 0,12655993 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,08247376 0,12648048 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,08247376 0,12640113 ! polyamine metabolic process GO:0006595 18 12 0,000 0,08247376 0,12632188 ! mitotic spindle organization GO:0007052 23 12 0,000 0,08247376 0,12624273 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,08247376 0,12616368 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,08247376 0,12608473 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,08247376 0,12600588 ! lipid digestion GO:0044241 21 12 0,000 0,08247376 0,12592713 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,08247376 0,12584847 ! entry into host cell GO:0030260 34 12 0,000 0,08247376 0,12576991 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08247376 0,12569145 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,08247376 0,12561309 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,08247376 0,12553483 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,08247376 0,12545666 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,08247376 0,1253786 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,08247376 0,12530062 ! regulation of phagocytosis GO:0050764 17 12 0,000 0,08247376 0,12522275 ! snRNA metabolic process GO:0016073 30 12 0,000 0,08247376 0,12514497 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,08247376 0,12506729 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,08247376 0,1249897 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,08247376 0,12491221 ! cranial nerve development GO:0021545 23 12 0,000 0,08247376 0,12483482 ! fucose catabolic process GO:0019317 25 12 0,000 0,08247376 0,12475752 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,08247376 0,12468032 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,08247376 0,12460322 ! autonomic nervous system development GO:0048483 24 12 0,000 0,08247376 0,12452621 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,08247376 0,12444929 ! zymogen activation GO:0031638 18 12 0,000 0,08247376 0,12437247 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,08247376 0,12429574 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,08247376 0,12421911 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,08247376 0,12414258 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,08247376 0,12406613 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,08247376 0,12398979 ! defense response to fungus GO:0050832 15 12 0,000 0,08247376 0,12391353 ! developmental induction GO:0031128 22 12 0,000 0,08247376 0,12383737 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,08247376 0,1237613 ! lamellipodium assembly GO:0030032 24 12 0,000 0,08247376 0,12368533 ! response to cold GO:0009409 17 12 0,000 0,08247376 0,12360945 ! regulation of synapse organization GO:0050807 18 12 0,000 0,08247376 0,12353366 ! embryonic limb morphogenesis GO:0030326 139 67 1,000 0,08313492 0,12444768 GO:0035113|embryonic appendage morphogenesis, ! secondary metabolic process GO:0019748 125 67 1,000 0,08313492 0,12437147 ! regulation of cellular response to stress GO:0080135 142 68 1,000 0,08526486 0,12747984 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 1,000 0,08526486 0,12740187 ! negative regulation of ligase activity GO:0051352 116 68 1,000 0,08526486 0,127324 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! positive regulation of T cell activation GO:0050870 124 68 1,000 0,08526486 0,12724622 ! regulation of lipase activity GO:0060191 137 68 1,000 0,08526486 0,12716854 ! adaptive immune response GO:0002250 126 68 1,000 0,08526486 0,12709095 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! cell projection assembly GO:0030031 138 68 1,000 0,08526486 0,12701345 ! cellular hormone metabolic process GO:0034754 120 69 1,000 0,08741124 0,13013142 ! homeostasis of number of cells GO:0048872 131 69 1,000 0,08741124 0,13005217 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,08903269 0,13238396 ! cGMP metabolic process GO:0046068 18 13 0,000 0,08903269 0,13230344 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,08903269 0,13222301 ! regulation of chemokine production GO:0032642 18 13 0,000 0,08903269 0,13214268 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,08903269 0,13206245 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,08903269 0,13198231 ! peroxisomal transport GO:0043574 28 13 0,000 0,08903269 0,13190228 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,08903269 0,13182233 ! organelle fusion GO:0048284 36 13 0,000 0,08903269 0,13174249 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,08903269 0,13166274 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,08903269 0,13158309 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,08903269 0,13150354 ! endocrine pancreas development GO:0031018 25 13 0,000 0,08903269 0,13142408 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,08903269 0,13134472 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,08903269 0,13126545 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,08903269 0,13118628 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,08903269 0,1311072 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,08903269 0,13102822 ! methionine metabolic process GO:0006555 31 13 0,000 0,08903269 0,13094934 ! plasma membrane organization GO:0007009 27 13 0,000 0,08903269 0,13087055 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,08903269 0,13079185 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,08903269 0,13071325 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,08903269 0,13063475 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,08903269 0,13055633 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! cytokine metabolic process GO:0042107 24 13 0,000 0,08903269 0,13047802 ! cellular carbohydrate catabolic process GO:0044275 17 13 0,000 0,08903269 0,13039979 ! exocrine system development GO:0035272 34 13 0,000 0,08903269 0,13032166 ! asymmetric protein localization GO:0008105 24 13 0,000 0,08903269 0,13024362 ! monoamine transport GO:0015844 21 13 0,000 0,08903269 0,13016568 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 0,000 0,08903269 0,13008783 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! L-glutamate transport GO:0015813 30 13 0,000 0,08903269 0,13001007 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,08903269 0,12993241 ! protein homotetramerization GO:0051289 24 13 0,000 0,08903269 0,12985484 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,08903269 0,12977736 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,08903269 0,12969997 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,08903269 0,12962268 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,08903269 0,12954547 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,08903269 0,12946836 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,08903269 0,12939135 ! histone methylation GO:0016571 29 13 0,000 0,08903269 0,12931442 ! chromatin silencing GO:0006342 29 13 0,000 0,08903269 0,12923758 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,08903269 0,12916084 ! regulation of erythrocyte differentiation GO:0045646 47 13 0,000 0,08903269 0,12908419 ! regulation of epidermis development GO:0045682 19 13 0,000 0,08903269 0,12900762 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,08903269 0,12893115 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,08903269 0,12885477 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,08903269 0,12877848 ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,08903269 0,12870228 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,08903269 0,12862617 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,08903269 0,12855015 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,08903269 0,12847422 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,08903269 0,12839838 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,08903269 0,12832263 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,08903269 0,12824696 ! insulin secretion GO:0030073 24 13 0,000 0,08903269 0,12817139 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,08903269 0,12809591 ! acrosome reaction GO:0007340 19 13 0,000 0,08903269 0,12802051 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,08903269 0,12794521 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,08903269 0,12786999 ! germ cell development GO:0007281 133 70 1,000 0,08957371 0,12857143 ! activation of immune response GO:0002253 120 70 1,000 0,08957371 0,12849593 ! cAMP-mediated signaling GO:0019933 124 71 1,000 0,09175194 0,13154341 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,09175194 0,13146626 ! appendage morphogenesis GO:0035107 150 72 1,000 0,09394558 0,13453052 GO:0035108|limb morphogenesis, ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,09554491 0,1367406 GO:0046579|positive regulation of Ras protein signal transduction, ! water transport GO:0006833 21 14 0,000 0,09554491 0,13666054 GO:0042044|fluid transport, ! non-recombinational repair GO:0000726 29 14 0,000 0,09554491 0,13658058 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,09554491 0,13650071 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,09554491 0,13642093 ! RNA polyadenylation GO:0043631 32 14 0,000 0,09554491 0,13634124 ! lipid localization GO:0010876 32 14 0,000 0,09554491 0,13626165 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,09554491 0,13618215 ! regulated secretory pathway GO:0045055 24 14 0,000 0,09554491 0,13610274 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,09554491 0,13602343 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,09554491 0,13594421 ! arginine metabolic process GO:0006525 21 14 0,000 0,09554491 0,13586508 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,09554491 0,13578604 ! organic alcohol transport GO:0015850 29 14 0,000 0,09554491 0,1357071 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,09554491 0,13562824 ! embryo implantation GO:0007566 30 14 0,000 0,09554491 0,13554948 ! neutral amino acid transport GO:0015804 28 14 0,000 0,09554491 0,13547081 ! bone mineralization GO:0030282 18 14 0,000 0,09554491 0,13539223 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,09554491 0,13531374 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,09554491 0,13523535 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,09554491 0,13515704 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,09554491 0,13507882 ! ribosome assembly GO:0042255 18 14 0,000 0,09554491 0,1350007 ! cerebellum development GO:0021549 23 14 0,000 0,09554491 0,13492266 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,09554491 0,13484472 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,09554491 0,13476686 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,09554491 0,1346891 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,09554491 0,13461142 ! NADP metabolic process GO:0006739 24 14 0,000 0,09554491 0,13453384 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,09554491 0,13445634 ! oxygen transport GO:0015671 22 14 0,000 0,09554491 0,13437893 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,09554491 0,13430161 ! male genitalia development GO:0030539 26 14 0,000 0,09554491 0,13422439 ! regulation of axon extension GO:0030516 43 14 0,000 0,09554491 0,13414724 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,09554491 0,13407019 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,09554491 0,13399323 ! appendage development GO:0048736 151 73 1,000 0,09615432 0,13477052 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 1,000 0,09615432 0,13469324 ! regulation of immune effector process GO:0002697 156 73 1,000 0,09615432 0,13461605 ! organelle localization GO:0051640 155 74 1,000 0,09837783 0,13765008 ! axon guidance GO:0007411 162 75 1,000 0,10061579 0,14070084 ! rhythmic process GO:0048511 142 75 1,000 0,10061579 0,14062035 ! lactation GO:0007595 30 15 0,000 0,10201075 0,14248844 ! reproductive cellular process GO:0048610 22 15 0,000 0,10201075 0,14240701 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,10201075 0,14232568 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,10201075 0,14224445 ! superoxide anion generation GO:0042554 22 15 0,000 0,10201075 0,14216331 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,10201075 0,14208225 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,10201075 0,1420013 ! copper ion transport GO:0006825 22 15 0,000 0,10201075 0,14192043 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,10201075 0,14183965 ! sulfate transport GO:0008272 27 15 0,000 0,10201075 0,14175897 ! response to cAMP GO:0051591 25 15 0,000 0,10201075 0,14167838 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,10201075 0,14159788 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,10201075 0,14151748 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,10201075 0,14143716 ! response to hexose stimulus GO:0009746 25 15 0,000 0,10201075 0,14135693 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,10201075 0,1412768 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,10201075 0,14119676 ! vesicle coating GO:0006901 38 15 0,000 0,10201075 0,1411168 ! regulation of exocytosis GO:0017157 26 15 0,000 0,10201075 0,14103694 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,10201075 0,14095717 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,10201075 0,14087749 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,10201075 0,14079789 ! regulation of vasodilation GO:0042312 27 15 0,000 0,10201075 0,14071839 ! histone deacetylation GO:0016575 24 15 0,000 0,10201075 0,14063898 ! positive regulation of oxidoreductase activity GO:0051353 22 15 0,000 0,10201075 0,14055966 ! water homeostasis GO:0030104 28 15 0,000 0,10201075 0,14048042 ! cofactor transport GO:0051181 30 15 0,000 0,10201075 0,14040128 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,10201075 0,14032223 ! muscle maintenance GO:0046716 26 15 0,000 0,10201075 0,14024326 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,10201075 0,14016438 ! intestinal absorption GO:0050892 31 15 0,000 0,10201075 0,1400856 ! dopamine metabolic process GO:0042417 35 15 0,000 0,10201075 0,1400069 ! heme biosynthetic process GO:0006783 33 15 0,000 0,10201075 0,13992828 ! cell killing GO:0001906 32 15 0,000 0,10201075 0,13984976 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,10201075 0,13977133 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,10201075 0,13969298 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,10201075 0,13961472 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,10201075 0,13953655 ! actin filament polymerization GO:0030041 27 15 0,000 0,10201075 0,13945846 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,10201075 0,13938047 ! regulation of blood pressure GO:0008217 134 76 1,000 0,10286787 0,140473 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,10513376 0,14348703 ! regulation of glucose metabolic process GO:0010906 28 16 0,000 0,10843056 0,14790389 ! positive regulation of cell size GO:0045793 29 16 0,000 0,10843056 0,14782135 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,10843056 0,14773891 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,10843056 0,14765655 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,10843056 0,14757429 ! bone remodeling GO:0046849 28 16 0,000 0,10843056 0,14749213 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,10843056 0,14741005 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10843056 0,14732806 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,10843056 0,14724617 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,10843056 0,14716437 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,10843056 0,14708265 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 0,000 0,10843056 0,14700103 ! startle response GO:0001964 28 16 0,000 0,10843056 0,1469195 ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,10843056 0,14683806 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,10843056 0,14675671 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,10843056 0,14667545 ! protein polyubiquitination GO:0000209 41 16 0,000 0,10843056 0,14659428 ! glutamate metabolic process GO:0006536 25 16 0,000 0,10843056 0,1465132 ! pituitary gland development GO:0021983 30 16 0,000 0,10843056 0,1464322 ! response to osmotic stress GO:0006970 27 16 0,000 0,10843056 0,1463513 ! lysosomal transport GO:0007041 31 16 0,000 0,10843056 0,14627049 ! fructose metabolic process GO:0006000 25 16 0,000 0,10843056 0,14618977 ! L-amino acid transport GO:0015807 33 16 0,000 0,10843056 0,14610913 ! stem cell development GO:0048864 46 16 0,000 0,10843056 0,14602859 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,10843056 0,14594813 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,10843056 0,14586776 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,10843056 0,14578748 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,10843056 0,14570729 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,10843056 0,14562719 ! neuron recognition GO:0008038 40 16 0,000 0,10843056 0,14554718 ! mRNA splice site selection GO:0006376 44 16 0,000 0,10843056 0,14546725 ! tissue regeneration GO:0042246 27 16 0,000 0,10843056 0,14538741 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,10843056 0,14530766 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,10843056 0,14522799 ! biomineral formation GO:0031214 22 16 0,000 0,10843056 0,14514842 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,10843056 0,14506893 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,10843056 0,14498952 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,10843056 0,14491021 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,10843056 0,14483098 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,10843056 0,14475184 ! peptide hormone processing GO:0016486 27 16 0,000 0,10843056 0,14467278 ! blood coagulation GO:0007596 151 79 1,000 0,10970575 0,1462943 GO:0050817|coagulation, ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 1,000 0,10970575 0,14621448 ! steroid biosynthetic process GO:0006694 146 79 1,000 0,10970575 0,14613476 ! response to steroid hormone stimulus GO:0048545 147 79 1,000 0,10970575 0,14605512 ! protein oligomerization GO:0051259 149 79 1,000 0,10970575 0,14597557 ! meiosis GO:0007126 143 81 1,000 0,11432932 0,15204492 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 1,000 0,11432932 0,1519622 ! negative regulation of hormone secretion GO:0046888 26 17 0,000 0,11480465 0,15251102 ! filopodium assembly GO:0046847 42 17 0,000 0,11480465 0,15242813 ! gene silencing by RNA GO:0031047 38 17 0,000 0,11480465 0,15234533 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,11480465 0,15226263 ! glial cell development GO:0021782 28 17 0,000 0,11480465 0,15218001 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,11480465 0,15209748 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,11480465 0,15201505 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,11480465 0,1519327 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,11480465 0,15185044 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,11480465 0,15176827 ! myoblast differentiation GO:0045445 50 17 0,000 0,11480465 0,15168619 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,11480465 0,15160419 ! regulation of survival gene product expression GO:0045884 38 17 0,000 0,11480465 0,15152229 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,11480465 0,15144047 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,11480465 0,15135875 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,11480465 0,15127711 ! NAD metabolic process GO:0019674 33 17 0,000 0,11480465 0,15119556 ! membrane budding GO:0006900 42 17 0,000 0,11480465 0,15111409 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,11480465 0,15103272 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,11480465 0,15095143 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,11480465 0,15087023 ! genitalia development GO:0048806 32 17 0,000 0,11480465 0,15078912 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,11480465 0,15070809 ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,11480465 0,15062715 ! steroid catabolic process GO:0006706 34 17 0,000 0,11480465 0,1505463 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,11480465 0,15046554 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,11480465 0,15038486 ! gas transport GO:0015669 26 17 0,000 0,11480465 0,15030426 ! organic cation transport GO:0015695 32 17 0,000 0,11480465 0,15022376 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,11480465 0,15014334 ! meiotic cell cycle GO:0051321 144 82 1,000 0,1166597 0,15248777 ! regulation of adenylate cyclase activity GO:0045761 165 83 1,000 0,11900208 0,15546635 ! intracellular protein transmembrane transport GO:0065002 165 83 1,000 0,11900208 0,15538326 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,12113335 0,15808161 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,12113335 0,15799721 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,12113335 0,15791289 ! limbic system development GO:0021761 40 18 0,000 0,12113335 0,15782867 ! negative regulation of ion transport GO:0043271 25 18 0,000 0,12113335 0,15774454 ! adult walking behavior GO:0007628 36 18 0,000 0,12113335 0,1576605 ! patterning of blood vessels GO:0001569 43 18 0,000 0,12113335 0,15757655 ! heart looping GO:0001947 34 18 0,000 0,12113335 0,15749269 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,12113335 0,15740892 ! centrosome cycle GO:0007098 26 18 0,000 0,12113335 0,15732523 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,12113335 0,15724164 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,12113335 0,15715813 ! glycine metabolic process GO:0006544 30 18 0,000 0,12113335 0,15707472 ! glutamine metabolic process GO:0006541 29 18 0,000 0,12113335 0,15699139 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,12113335 0,15690815 ! DNA integration GO:0015074 32 18 0,000 0,12113335 0,15682499 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,12113335 0,15674193 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,12113335 0,15665895 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 0,000 0,12113335 0,15657607 ! neural crest cell migration GO:0001755 41 18 0,000 0,12113335 0,15649327 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,12113335 0,15641055 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,12113335 0,15632793 GO:0046466|membrane lipid catabolic process, ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,12113335 0,15624539 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,12113335 0,15616294 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,12113335 0,15608057 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 0,000 0,12113335 0,15599829 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,12113335 0,1559161 ! detection of bacterium GO:0016045 22 18 0,000 0,12113335 0,155834 ! nerve development GO:0021675 34 18 0,000 0,12113335 0,15575198 ! microspike assembly GO:0030035 46 18 0,000 0,12113335 0,15567005 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,12113335 0,1555882 ! response to metal ion GO:0010038 158 84 1,000 0,12135618 0,15579251 ! regulation of ligase activity GO:0051340 147 84 1,000 0,12135618 0,15571069 ! hemostasis GO:0007599 165 85 1,000 0,12372171 0,15866254 ! regulation of cyclase activity GO:0031279 168 85 1,000 0,12372171 0,1585793 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,12372171 0,15849614 ! cellular response to hormone stimulus GO:0032870 182 85 1,000 0,12372171 0,15841307 ! regulation of cAMP biosynthetic process GO:0030817 173 86 1,000 0,12609839 0,1613716 ! regulation of lyase activity GO:0051339 169 86 1,000 0,12609839 0,16128711 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,12741697 0,16288837 ! positive regulation of translation GO:0045727 31 19 0,000 0,12741697 0,16280317 ! negative regulation of defense response GO:0031348 27 19 0,000 0,12741697 0,16271807 ! neuron maturation GO:0042551 46 19 0,000 0,12741697 0,16263305 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,12741697 0,16254813 ! positive regulation of hormone secretion GO:0046887 35 19 0,000 0,12741697 0,16246329 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,12741697 0,16237854 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,12741697 0,16229388 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,12741697 0,16220931 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,12741697 0,16212483 ! memory GO:0007613 34 19 0,000 0,12741697 0,16204043 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,12741697 0,16195612 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,12741697 0,1618719 GO:0042744|hydrogen peroxide catabolic process, ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,12741697 0,16178777 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 0,000 0,12741697 0,16170372 ! cerebral cortex development GO:0021987 40 19 0,000 0,12741697 0,16161976 ! heme metabolic process GO:0042168 40 19 0,000 0,12741697 0,16153589 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,12741697 0,16145211 ! response to fungus GO:0009620 26 19 0,000 0,12741697 0,16136841 ! peptide cross-linking GO:0018149 39 19 0,000 0,12741697 0,1612848 ! protein export from nucleus GO:0006611 40 19 0,000 0,12741697 0,16120128 ! heart process GO:0003015 32 19 0,000 0,12741697 0,16111784 GO:0060047|heart contraction, ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,12741697 0,16103449 ! visual learning GO:0008542 38 19 0,000 0,12741697 0,16095122 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,12741697 0,16086804 ! vitamin transport GO:0051180 31 19 0,000 0,12741697 0,16078495 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,12741697 0,16070194 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,12741697 0,16061902 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,12741697 0,16053619 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,12741697 0,16045344 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,12741697 0,16037077 ! cilium assembly GO:0042384 38 19 0,000 0,12741697 0,16028819 ! peptide hormone secretion GO:0030072 32 19 0,000 0,12741697 0,1602057 ! regulation of cAMP metabolic process GO:0030814 182 89 1,000 0,13329257 0,16750707 ! protein secretion GO:0009306 45 20 0,000 0,13365585 0,16787724 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,13365585 0,16779098 ! positive regulation of ossification GO:0045778 50 20 0,000 0,13365585 0,1677048 ! positive regulation of angiogenesis GO:0045766 50 20 0,000 0,13365585 0,16761871 ! skin development GO:0043588 42 20 0,000 0,13365585 0,1675327 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,13365585 0,16744679 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,13365585 0,16736096 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,13365585 0,16727523 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,13365585 0,16718958 ! regulation of carbohydrate metabolic process GO:0006109 37 20 0,000 0,13365585 0,16710401 GO:0010675|regulation of cellular carbohydrate metabolic process, ! retinoid metabolic process GO:0001523 34 20 0,000 0,13365585 0,16701854 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,13365585 0,16693315 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,13365585 0,16684785 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,13365585 0,16676264 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,13365585 0,16667751 GO:0030968|endoplasmic reticulum unfolded protein response, ! actin filament bundle formation GO:0051017 47 20 0,000 0,13365585 0,16659247 ! body fluid secretion GO:0007589 33 20 0,000 0,13365585 0,16650752 ! peptide secretion GO:0002790 38 20 0,000 0,13365585 0,16642265 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,13365585 0,16633787 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,13365585 0,16625318 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,13365585 0,16616857 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,13365585 0,16608405 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,13365585 0,16599961 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 0,000 0,13365585 0,16591526 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,13365585 0,165831 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,13365585 0,16574682 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,13365585 0,16566273 ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,13365585 0,16557872 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,13365585 0,1654948 ! negative regulation of translation GO:0017148 32 20 0,000 0,13365585 0,16541096 ! response to inorganic substance GO:0010035 173 90 1,000 0,1357111 0,16786947 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 1,000 0,13813942 0,17078674 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,13985029 0,1728145 ! hormone secretion GO:0046879 39 21 0,000 0,13985029 0,17272713 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,13985029 0,17263985 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,13985029 0,17255266 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,13985029 0,17246556 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,13985029 0,17237854 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,13985029 0,17229161 GO:0006692|prostanoid metabolic process, ! sensory perception of pain GO:0019233 33 21 0,000 0,13985029 0,17220477 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,13985029 0,17211802 ! diencephalon development GO:0021536 36 21 0,000 0,13985029 0,17203135 ! collagen fibril organization GO:0030199 62 21 0,000 0,13985029 0,17194477 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,13985029 0,17185828 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,13985029 0,17177188 ! collagen catabolic process GO:0030574 29 21 0,000 0,13985029 0,17168556 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,13985029 0,17159933 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,13985029 0,17151319 ! sperm-egg recognition GO:0035036 23 21 0,000 0,13985029 0,17142713 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,14600062 0,17887639 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,14600062 0,17878672 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,14600062 0,17869715 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,14600062 0,17860767 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,14600062 0,17851827 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,14600062 0,17842897 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,14600062 0,17833976 ! vacuolar transport GO:0007034 41 22 0,000 0,14600062 0,17825063 ! central nervous system neuron development GO:0021954 47 22 0,000 0,14600062 0,17816159 ! fucose metabolic process GO:0006004 44 22 0,000 0,14600062 0,17807265 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,14600062 0,17798379 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,14600062 0,17789502 ! stem cell differentiation GO:0048863 57 22 0,000 0,14600062 0,17780634 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,14600062 0,17771774 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 0,000 0,14600062 0,17762924 ! cytolysis GO:0019835 27 22 0,000 0,14600062 0,17754082 ! vasodilation GO:0042311 40 22 0,000 0,14600062 0,17745249 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,14600062 0,17736425 ! detection of chemical stimulus GO:0009593 42 22 0,000 0,14600062 0,1772761 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,14600062 0,17718803 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,14600062 0,17710006 ! sarcomere organization GO:0045214 32 22 0,000 0,14600062 0,17701217 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,14600062 0,17692436 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,14600062 0,17683664 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,14600062 0,17674902 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 0,000 0,14600062 0,17666147 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,14600062 0,17657402 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 1,000 0,14794542 0,17883753 ! response to protein stimulus GO:0051789 158 96 1,000 0,15041883 0,18173749 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 0,000 0,15210714 0,18368648 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,15210714 0,18359572 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,15210714 0,18350506 ! gluconeogenesis GO:0006094 38 23 0,000 0,15210714 0,18341448 ! glycerol metabolic process GO:0006071 40 23 0,000 0,15210714 0,183324 ! viral genome replication GO:0019079 44 23 0,000 0,15210714 0,1832336 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,15210714 0,18314329 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,15210714 0,18305308 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,15210714 0,18296295 ! visual behavior GO:0007632 46 23 0,000 0,15210714 0,18287291 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,15210714 0,18278295 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,15210714 0,18269309 ! peroxisome organization GO:0007031 43 23 0,000 0,15210714 0,18260331 ! lysosome organization GO:0007040 47 23 0,000 0,15210714 0,18251363 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,15210714 0,18242403 ! vesicle targeting GO:0006903 49 23 0,000 0,15210714 0,18233452 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,15210714 0,18224509 GO:0060415|muscle tissue morphogenesis, ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,15210714 0,18215576 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,15210714 0,18206651 ! DNA modification GO:0006304 36 23 0,000 0,15210714 0,18197735 ! fatty acid transport GO:0015908 47 23 0,000 0,15210714 0,18188827 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,15210714 0,18179929 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,15210714 0,18171039 ! hormone transport GO:0009914 41 23 0,000 0,15210714 0,18162158 ! cell-cell recognition GO:0009988 28 23 0,000 0,15210714 0,18153285 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,15210714 0,18144421 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,15210714 0,18135566 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,15210714 0,18126719 ! regulation of nucleotide metabolic process GO:0006140 197 98 1,000 0,15539021 0,18508936 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 0,000 0,15817017 0,18830883 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,15817017 0,18821711 GO:0016444|somatic cell DNA recombination, ! regulation of cellular catabolic process GO:0031329 55 24 0,000 0,15817017 0,18812547 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,15817017 0,18803393 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,15817017 0,18794247 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,15817017 0,1878511 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,15817017 0,18775982 ! calcium-independent cell-cell adhesion GO:0016338 36 24 0,000 0,15817017 0,18766863 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,15817017 0,18757753 ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,15817017 0,18748652 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,15817017 0,1873956 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,15817017 0,18730476 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,15817017 0,18721401 GO:0051693|actin filament capping, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,15817017 0,18712335 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,15817017 0,18703278 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,15817017 0,18694229 ! membrane depolarization GO:0051899 45 24 0,000 0,15817017 0,1868519 ! pallium development GO:0021543 56 24 0,000 0,15817017 0,18676158 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,15817017 0,18667136 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,15817017 0,18658123 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,15817017 0,18649118 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,15817017 0,18640122 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,15817017 0,18631134 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,15817017 0,18622155 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,15817017 0,18613185 ! regulation of amine transport GO:0051952 41 24 0,000 0,15817017 0,18604223 ! mRNA transport GO:0051028 185 100 1,000 0,16039273 0,18856566 ! positive regulation of immune response GO:0050778 175 100 1,000 0,16039273 0,18847496 ! hormone metabolic process GO:0042445 171 100 1,000 0,16039273 0,18838434 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,16419001 0,19275165 ! phototransduction GO:0007602 37 25 0,000 0,16419001 0,19265907 ! keratinization GO:0031424 37 25 0,000 0,16419001 0,19256658 ! vacuole organization GO:0007033 49 25 0,000 0,16419001 0,19247418 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,16419001 0,19238187 ! regulation of insulin secretion GO:0050796 42 25 0,000 0,16419001 0,19228964 ! interaction with host GO:0051701 66 25 0,000 0,16419001 0,1921975 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,16419001 0,19210546 ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,16419001 0,1920135 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,16419001 0,19192162 ! liver development GO:0001889 55 25 0,000 0,16419001 0,19182984 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,17016697 0,19871793 ! initiation of viral infection GO:0019059 60 26 0,000 0,17016697 0,19862299 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,17016697 0,19852813 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,17016697 0,19843337 ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,17016697 0,1983387 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,17016697 0,19824412 GO:0006479|protein amino acid methylation, ! microtubule organizing center organization GO:0031023 42 26 0,000 0,17016697 0,19814962 GO:0051297|centrosome organization, ! spinal cord development GO:0021510 54 26 0,000 0,17016697 0,19805522 ! digestive system process GO:0022600 49 26 0,000 0,17016697 0,19796091 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,17016697 0,19786669 ! osteoblast differentiation GO:0001649 63 26 0,000 0,17016697 0,19777256 ! neural crest cell development GO:0014032 59 26 0,000 0,17016697 0,19767851 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,17016697 0,19758456 ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,17016697 0,19749069 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,17016697 0,19739692 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,17016697 0,19730323 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,17016697 0,19720964 ! positive regulation of nuclear division GO:0051785 41 26 0,000 0,17016697 0,19711613 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 0,000 0,17016697 0,19702271 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,17016697 0,19692938 ! telomere organization GO:0032200 46 26 0,000 0,17016697 0,19683613 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,17016697 0,19674298 ! alditol metabolic process GO:0019400 44 26 0,000 0,17016697 0,19664991 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,17016697 0,19655693 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,17610136 0,20331551 ! embryonic pattern specification GO:0009880 49 27 0,000 0,17610136 0,20321947 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,17610136 0,20312352 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,17610136 0,20302766 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,17610136 0,2029319 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,17610136 0,20283622 ! iron ion transport GO:0006826 65 27 0,000 0,17610136 0,20274063 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,17610136 0,20264514 ! superoxide metabolic process GO:0006801 41 27 0,000 0,17610136 0,20254973 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,17610136 0,20245441 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,17610136 0,20235918 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,17610136 0,20226404 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,17610136 0,202169 ! neuron fate commitment GO:0048663 52 28 0,000 0,18199347 0,20883516 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,18199347 0,20873712 ! circadian rhythm GO:0007623 56 28 0,000 0,18199347 0,20863916 ! fat cell differentiation GO:0045444 57 28 0,000 0,18199347 0,2085413 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,18199347 0,20844353 ! sperm motility GO:0030317 37 28 0,000 0,18199347 0,20834586 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,18199347 0,20824827 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,18199347 0,20815078 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,18199347 0,20805337 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,18199347 0,20795606 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,18199347 0,20785884 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,18199347 0,20776171 ! translational initiation GO:0006413 66 29 0,000 0,18784362 0,21434001 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,18784362 0,21423994 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,18784362 0,21413997 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,18784362 0,21404009 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! autophagy GO:0006914 47 29 0,000 0,18784362 0,21394031 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,18784362 0,21384061 ! regulation of peptide secretion GO:0002791 52 29 0,000 0,18784362 0,21374101 ! synaptogenesis GO:0007416 46 29 0,000 0,18784362 0,21364151 ! negative regulation of neuron differentiation GO:0045665 46 29 0,000 0,18784362 0,21354209 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,18784362 0,21344277 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,18784362 0,21334354 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,19365208 0,21983831 ! phenol metabolic process GO:0018958 56 30 0,000 0,19365208 0,2197362 ! negative regulation of protein complex assembly GO:0031333 68 30 0,000 0,19365208 0,21963419 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,19365208 0,21953227 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,19365208 0,21943045 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,19365208 0,21932872 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,19365208 0,21922708 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,19365208 0,21912554 ! acute-phase response GO:0006953 50 30 0,000 0,19365208 0,21902409 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,19365208 0,21892274 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 0,000 0,19365208 0,21882148 ! myofibril assembly GO:0030239 50 30 0,000 0,19365208 0,21872032 GO:0055002|striated muscle cell development, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,19365208 0,21861924 ! cell fate determination GO:0001709 64 30 0,000 0,19365208 0,21851826 ! phospholipid transport GO:0015914 65 30 0,000 0,19365208 0,21841738 ! sterol biosynthetic process GO:0016126 56 30 0,000 0,19365208 0,21831659 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,19365208 0,21821589 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,19365208 0,21811528 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,19941917 0,22450739 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,19941917 0,22440398 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,19941917 0,22430066 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,19941917 0,22419744 ! regulation of innate immune response GO:0045088 57 31 0,000 0,19941917 0,22409431 ! iron ion homeostasis GO:0055072 60 31 0,000 0,19941917 0,22399128 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,19941917 0,22388835 ! detection of light stimulus GO:0009583 44 31 0,000 0,19941917 0,2237855 ! natural killer cell activation GO:0030101 50 31 0,000 0,19941917 0,22368275 ! cofactor catabolic process GO:0051187 54 31 0,000 0,19941917 0,2235801 ! eye morphogenesis GO:0048592 65 31 0,000 0,19941917 0,22347754 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,20514518 0,22978893 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,20514518 0,22968362 ! collagen metabolic process GO:0032963 49 32 0,000 0,20514518 0,22957841 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,20514518 0,22947329 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,20514518 0,22936827 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,20514518 0,22926334 ! muscle cell development GO:0055001 52 32 0,000 0,20514518 0,22915851 ! mesoderm formation GO:0001707 73 32 0,000 0,20514518 0,22905378 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,20514518 0,22894914 ! BMP signaling pathway GO:0030509 71 32 0,000 0,20514518 0,2288446 ! positive regulation of catabolic process GO:0009896 72 32 0,000 0,20514518 0,22874015 ! gene silencing GO:0016458 71 32 0,000 0,20514518 0,2286358 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,21083038 0,23486486 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,21083038 0,23475781 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,21083038 0,23465086 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,21083038 0,234544 ! triglyceride metabolic process GO:0006641 46 33 0,000 0,21083038 0,23443725 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,21083038 0,23433059 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,21083038 0,23422402 ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,21083038 0,23411756 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,21083038 0,23401119 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,21083038 0,23390492 ! glial cell differentiation GO:0010001 67 34 0,000 0,21647509 0,24005839 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,21647509 0,23994947 ! cholesterol transport GO:0030301 62 34 0,000 0,21647509 0,23984065 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,21647509 0,23973193 ! spliceosome assembly GO:0000245 75 34 0,000 0,21647509 0,23962331 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,21647509 0,23951478 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,21647509 0,23940636 ! formation of primary germ layer GO:0001704 76 34 0,000 0,21647509 0,23929803 ! cell fate specification GO:0001708 56 34 0,000 0,21647509 0,2391898 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,21647509 0,23908166 ! adult locomotory behavior GO:0008344 62 34 0,000 0,21647509 0,23897363 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 0,000 0,21647509 0,23886569 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,22207957 0,24493923 ! negative regulation of secretion GO:0051048 68 35 0,000 0,22207957 0,2448287 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,22207957 0,24471827 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,22207957 0,24460794 ! positive regulation of endocytosis GO:0045807 56 35 0,000 0,22207957 0,2444977 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,22207957 0,24438757 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,22207957 0,24427753 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,22207957 0,2441676 ! ceramide metabolic process GO:0006672 72 35 0,000 0,22207957 0,24405776 ! telencephalon development GO:0021537 81 35 0,000 0,22207957 0,24394802 ! sterol transport GO:0015918 63 35 0,000 0,22207957 0,24383838 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,22207957 0,24372884 ! placenta development GO:0001890 53 35 0,000 0,22207957 0,2436194 ! vesicle localization GO:0051648 70 35 0,000 0,22207957 0,24351005 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 0,000 0,22764413 0,2494996 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,22764413 0,24938772 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 0,000 0,22764413 0,24927593 ! protein targeting to membrane GO:0006612 75 36 0,000 0,22764413 0,24916425 ! regulation of proteolysis GO:0030162 77 36 0,000 0,22764413 0,24905267 ! aerobic respiration GO:0009060 56 36 0,000 0,22764413 0,24894119 ! cytokine production GO:0001816 68 36 0,000 0,22764413 0,2488298 ! embryonic organ development GO:0048568 67 36 0,000 0,22764413 0,24871852 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,22764413 0,24860734 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,22764413 0,24849625 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,23316904 0,25441356 ! odontogenesis GO:0042476 74 37 0,000 0,23316904 0,25429998 ! actomyosin structure organization GO:0031032 68 37 0,000 0,23316904 0,2541865 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 0,000 0,23865458 0,26005046 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 0,000 0,23865458 0,25993452 ! organic anion transport GO:0015711 82 38 0,000 0,23865458 0,25981869 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,23865458 0,25970295 ! neutral lipid metabolic process GO:0006638 54 38 0,000 0,23865458 0,25958732 GO:0006639|acylglycerol metabolic process, ! spermatid development GO:0007286 69 38 0,000 0,23865458 0,2594718 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,24410103 0,26527527 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,24410103 0,26515732 ! carbohydrate homeostasis GO:0033500 59 39 0,000 0,24410103 0,26503947 GO:0042593|glucose homeostasis, ! nucleotide catabolic process GO:0009166 70 39 0,000 0,24410103 0,26492173 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,24410103 0,26480409 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,24410103 0,26468656 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,24410103 0,26456913 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,24950867 0,27031028 GO:0006956|complement activation, ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,24950867 0,27019046 ! learning GO:0007612 82 40 0,000 0,24950867 0,27007075 ! lipid homeostasis GO:0055088 75 40 0,000 0,24950867 0,26995114 ! mismatch repair GO:0006298 58 40 0,000 0,24950867 0,26983164 ! glycerol ether metabolic process GO:0006662 57 40 0,000 0,24950867 0,26971225 ! RNA export from nucleus GO:0006405 61 41 0,000 0,25487778 0,27539426 ! mRNA catabolic process GO:0006402 79 41 0,000 0,25487778 0,27527251 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,25487778 0,27515087 ! regulation of hormone secretion GO:0046883 69 41 0,000 0,25487778 0,27502933 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,25487778 0,27490791 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,25487778 0,27478659 ! gliogenesis GO:0042063 91 41 0,000 0,25487778 0,27466538 ! feeding behavior GO:0007631 69 41 0,000 0,25487778 0,27454427 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,25487778 0,27442328 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,25487778 0,27430239 GO:0015986|ATP synthesis coupled proton transport, ! spermatid differentiation GO:0048515 73 41 0,000 0,25487778 0,2741816 ! RNA modification GO:0009451 64 41 0,000 0,25487778 0,27406092 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 0,000 0,26020863 0,2796699 ! ear morphogenesis GO:0042471 64 42 0,000 0,26020863 0,27954691 ! organic ether metabolic process GO:0018904 59 42 0,000 0,26020863 0,27942403 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,26020863 0,27930126 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,26020863 0,2791786 ! regulation of protein secretion GO:0050708 77 42 0,000 0,26020863 0,27905605 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,26020863 0,2789336 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,26550148 0,28448251 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,26550148 0,28435779 ! glucose transport GO:0015758 66 43 0,000 0,26550148 0,28423318 ! striated muscle cell differentiation GO:0051146 91 43 0,000 0,26550148 0,28410868 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,26550148 0,28398429 ! hormone-mediated signaling GO:0009755 84 43 0,000 0,26550148 0,28386001 ! ion transmembrane transport GO:0034220 79 43 0,000 0,26550148 0,28373584 ! regulation of myeloid cell differentiation GO:0045637 105 43 0,000 0,26550148 0,28361177 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,27075662 0,28909896 ! hexose transport GO:0008645 68 44 0,000 0,27075662 0,28897266 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,27075662 0,28884647 ! striated muscle contraction GO:0006941 85 44 0,000 0,27075662 0,28872039 ! phagocytosis GO:0006909 105 44 0,000 0,27075662 0,28859442 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,27075662 0,28846857 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,2759743 0,2938994 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,2759743 0,29377134 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,2759743 0,29364339 ! biopolymer methylation GO:0043414 91 45 0,000 0,2759743 0,29351555 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,2759743 0,29338783 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,2811548 0,2987652 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,2811548 0,2986353 ! glycolysis GO:0006096 71 46 0,000 0,2811548 0,29850551 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,2811548 0,29837584 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,2811548 0,29824628 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,2914053 0,30898574 ! regulation of JAK-STAT cascade GO:0046425 76 48 0,000 0,2914053 0,30885169 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,2914053 0,30871775 ! JAK-STAT cascade GO:0007259 82 48 0,000 0,2914053 0,30858394 ! methylation GO:0032259 97 48 0,000 0,2914053 0,30845023 ! response to calcium ion GO:0051592 94 49 0,000 0,29647581 0,31368143 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,29647581 0,31354563 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,29647581 0,31340996 ! protein homooligomerization GO:0051260 84 49 0,000 0,29647581 0,3132744 ! regulation of ion transport GO:0043269 86 50 0,000 0,30151019 0,31845629 ! endocrine system development GO:0035270 109 50 0,000 0,30151019 0,31831866 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,30151019 0,31818116 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,30151019 0,31804378 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,30151019 0,31790651 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,30151019 0,31776937 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,30151019 0,31763234 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,30151019 0,31749543 ! viral infectious cycle GO:0019058 104 51 0,000 0,30650868 0,32261986 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,30650868 0,32248092 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,31147154 0,32756133 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,31147154 0,32742038 ! excretion GO:0007588 87 52 0,000 0,31147154 0,32727956 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,31147154 0,32713885 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,31147154 0,32699827 ! amino acid activation GO:0043038 98 52 0,000 0,31147154 0,3268578 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,31639902 0,33188614 ! inner ear development GO:0048839 89 53 0,000 0,31639902 0,3317437 ! chromatin remodeling GO:0006338 122 53 0,000 0,31639902 0,33160138 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 0,000 0,31639902 0,33145918 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,31639902 0,33131711 ! regulation of translational initiation GO:0006446 87 54 0,000 0,32129138 0,33629599 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,32129138 0,33615196 ! neuromuscular process GO:0050905 107 54 0,000 0,32129138 0,33600806 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,32129138 0,33586429 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,32129138 0,33572063 ! RNA catabolic process GO:0006401 103 55 0,000 0,32614886 0,34065056 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,32614886 0,34050498 ! cell recognition GO:0008037 98 55 0,000 0,32614886 0,34035953 ! cell maturation GO:0048469 107 55 0,000 0,32614886 0,3402142 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,32614886 0,340069 ! glucose catabolic process GO:0006007 88 56 0,000 0,33097171 0,34495047 ! RNA elongation GO:0006354 90 56 0,000 0,33097171 0,34480336 ! chloride transport GO:0006821 102 57 0,000 0,33576018 0,34964285 ! heart morphogenesis GO:0003007 105 57 0,000 0,33576018 0,34949387 ! regulation of actin filament length GO:0030832 118 58 0,000 0,34051451 0,35429172 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,34051451 0,35414089 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,34051451 0,35399019 ! gastrulation GO:0007369 122 58 0,000 0,34051451 0,35383962 ! positive regulation of organelle organization GO:0010638 108 58 0,000 0,34051451 0,35368918 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,34051451 0,35353886 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,34992172 0,36315156 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,34992172 0,36299735 ! adult behavior GO:0030534 104 60 0,000 0,34992172 0,36284328 ! positive regulation of secretion GO:0051047 110 61 0,000 0,35457508 0,36751249 ! regulation of cellular component size GO:0032535 125 61 0,000 0,35457508 0,36735663 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,35457508 0,3672009 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,35457508 0,36704531 ! camera-type eye development GO:0043010 126 61 0,000 0,35457508 0,36688985 ! proton transport GO:0015992 117 61 0,000 0,35457508 0,36673452 ! viral reproductive process GO:0022415 132 62 0,000 0,35919527 0,37135592 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,35919527 0,37119883 ! tRNA processing GO:0008033 102 62 0,000 0,35919527 0,37104188 ! regulation of protein complex assembly GO:0043254 132 63 0,000 0,3637825 0,37562158 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,3637825 0,37546289 ! hydrogen transport GO:0006818 121 64 0,000 0,36833703 0,38000311 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,36833703 0,37984271 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,37285909 0,38434377 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,37285909 0,38418167 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,37734889 0,3886439 ! regulation of lipid metabolic process GO:0019216 132 66 0,000 0,37734889 0,38848013 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,38180668 0,39290384 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,38180668 0,39273841 ! hexose catabolic process GO:0019320 113 68 0,000 0,38623268 0,39712392 ! extracellular matrix organization GO:0030198 146 68 0,000 0,38623268 0,39695685 ! detection of external stimulus GO:0009581 102 68 0,000 0,38623268 0,39678992 ! viral reproduction GO:0016032 142 68 0,000 0,38623268 0,39662313 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,38623268 0,39645648 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,39062711 0,40079883 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,39062711 0,40063057 ! developmental maturation GO:0021700 128 69 0,000 0,39062711 0,40046245 ! single fertilization GO:0007338 83 69 0,000 0,39062711 0,40029447 ! cell redox homeostasis GO:0045454 114 70 0,000 0,3949902 0,40459583 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,3949902 0,40442626 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,39932218 0,40869044 ! carbohydrate transport GO:0008643 114 72 0,000 0,40362325 0,41291944 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,40362325 0,41274659 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,40362325 0,4125739 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,40362325 0,41240134 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,40362325 0,41222893 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,40789366 0,4164163 ! acute inflammatory response GO:0002526 118 74 0,000 0,4121336 0,42056908 ! amino acid transport GO:0006865 148 74 0,000 0,4121336 0,42039348 ! transition metal ion transport GO:0000041 143 75 0,000 0,4163433 0,4245103 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,4163433 0,4243332 ! eye development GO:0001654 155 75 0,000 0,4163433 0,42415625 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,42052297 0,42823577 ! learning or memory GO:0007611 161 76 0,000 0,42052297 0,42805734 ! amine catabolic process GO:0009310 136 77 0,000 0,42467283 0,43210151 ! neurotransmitter transport GO:0006836 142 77 0,000 0,42467283 0,43192162 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,42467283 0,43174187 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,42467283 0,43156228 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,42879309 0,43556819 ! antigen processing and presentation GO:0019882 117 78 0,000 0,42879309 0,43538716 ! fertilization GO:0009566 99 78 0,000 0,42879309 0,43520628 ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,43288395 0,43917587 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,43288395 0,43899356 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,43694563 0,4429287 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,43694563 0,44274499 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,44097833 0,44664596 ! inorganic anion transport GO:0015698 156 83 0,000 0,44895763 0,45453937 ! digestion GO:0007586 130 84 0,000 0,45290464 0,4583455 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,45682348 0,46211999 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,45682348 0,46192871 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,46457749 0,46957501 ! alcohol catabolic process GO:0046164 142 87 0,000 0,46457749 0,46938081 ! nucleosome assembly GO:0006334 126 87 0,000 0,46457749 0,46918677 ! cellular respiration GO:0045333 143 88 0,000 0,46841305 0,4728649 ! amine biosynthetic process GO:0009309 146 88 0,000 0,46841305 0,47266959 ! sensory perception of smell GO:0007608 117 88 0,000 0,46841305 0,47247443 ! chromatin assembly GO:0031497 128 88 0,000 0,46841305 0,47227943 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,46841305 0,4720846 ! cellular defense response GO:0006968 123 89 0,000 0,47222123 0,47572638 ! regulation of neurological system process GO:0031644 175 89 0,000 0,47222123 0,47553028 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,47600225 0,47914029 ! response to unfolded protein GO:0006986 139 90 0,000 0,47600225 0,47894295 ! defense response to bacterium GO:0042742 112 91 0,000 0,47975628 0,48252144 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,48348352 0,48607006 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,48718416 0,48958902 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,48718416 0,48938771 ! vitamin metabolic process GO:0006766 153 93 0,000 0,48718416 0,48918656 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,49085839 0,4926734 ! sterol metabolic process GO:0016125 166 94 0,000 0,49085839 0,49247107 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,49085839 0,49226891 ! nucleosome organization GO:0034728 143 95 0,000 0,4945064 0,4957239 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,4945064 0,49552057 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,4945064 0,4953174 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,4945064 0,4951144 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,5017245 0,50213558 ! transcription initiation GO:0006352 171 97 0,000 0,5017245 0,50192996 ! forebrain development GO:0030900 210 98 0,000 0,50529496 0,50529496