pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6306-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! cellular response to insulin stimulus GO:0032869 52 34 6,000 3,534E-08 8,129E-05 ! negative regulation of phosphorylation GO:0042326 41 23 5,000 7,559E-08 8,693E-05 ! insulin receptor signaling pathway GO:0008286 40 24 5,000 9,996E-08 7,664E-05 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 5,000 1,305E-07 7,501E-05 GO:0045936|negative regulation of phosphate metabolic process, ! response to insulin stimulus GO:0032868 63 43 6,000 1,964E-07 9,036E-05 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 3,000 3,168E-07 1,214E-04 ! induction of positive chemotaxis GO:0050930 14 8 3,000 6,287E-07 2,066E-04 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 6,000 6,603E-07 1,898E-04 ! cellular response to hormone stimulus GO:0032870 109 74 7,000 6,761E-07 1,728E-04 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 3,000 1,123E-06 2,583E-04 ! negative regulation of protein kinase activity GO:0006469 99 57 6,000 1,434E-06 2,999E-04 ! response to peptide hormone stimulus GO:0043434 84 57 6,000 1,434E-06 2,749E-04 ! negative regulation of kinase activity GO:0033673 100 58 6,000 1,618E-06 2,862E-04 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 3,000 1,857E-06 3,051E-04 GO:0010812|negative regulation of cell-substrate adhesion, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 1,857E-06 2,847E-04 ! negative regulation of transferase activity GO:0051348 105 61 6,000 2,29E-06 3,291E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 2,5E-06 3,383E-04 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 2,896E-06 3,7E-04 GO:0050927|positive regulation of positive chemotaxis, ! negative regulation of glucose import GO:0046325 14 11 3,000 2,896E-06 3,505E-04 GO:0010829|negative regulation of glucose transport, ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 3,000 6,177E-06 7,104E-04 ! activation of MAPKK activity GO:0000186 21 14 3,000 8,581E-06 9,399E-04 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 9,387E-06 9,813E-04 ! regulation of protein stability GO:0031647 48 32 4,000 1,453E-05 1,453E-03 ! activation of MAPKKK activity GO:0000185 10 6 2,000 1,864E-05 1,786E-03 ! ER overload response GO:0006983 7 6 2,000 1,864E-05 1,715E-03 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 1,864E-05 1,649E-03 ! regulation of glucose import GO:0046324 21 18 3,000 2,543E-05 2,167E-03 GO:0010827|regulation of glucose transport, ! sex determination GO:0007530 29 19 3,000 3,197E-05 2,626E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 3,238E-05 2,568E-03 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 3,238E-05 2,482E-03 ! positive regulation of locomotion GO:0040017 35 20 3,000 3,965E-05 2,942E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 3,000 4,86E-05 3,493E-03 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 2,000 5,143E-05 3,584E-03 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 5,143E-05 3,479E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 5,143E-05 3,379E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 5,143E-05 3,286E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 5,143E-05 3,197E-03 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 5,143E-05 3,113E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 6,000 5,702E-05 3,362E-03 ! vasculogenesis GO:0001570 33 22 3,000 5,895E-05 3,389E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 5,895E-05 3,307E-03 GO:0010810|regulation of cell-substrate adhesion, ! regulation of behavior GO:0050795 38 22 3,000 5,895E-05 3,228E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 6,359E-05 3,401E-03 ! positive regulation of phosphorylation GO:0042327 102 70 5,000 6,684E-05 3,494E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 7,081E-05 3,619E-03 ! negative regulation of cell migration GO:0030336 92 44 4,000 7,117E-05 3,558E-03 ! regulation of developmental growth GO:0048638 13 9 2,000 7,658E-05 3,747E-03 ! motor axon guidance GO:0008045 14 9 2,000 7,658E-05 3,669E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 5,000 7,836E-05 3,678E-03 GO:0045937|positive regulation of phosphate metabolic process, ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 9,96E-05 4,582E-03 ! regulation of B cell proliferation GO:0030888 15 10 2,000 1,086E-04 4,898E-03 ! detection of bacterium GO:0016045 10 10 2,000 1,086E-04 4,803E-03 ! negative regulation of protein modification process GO:0031400 50 26 3,000 1,168E-04 5,069E-03 ! positive regulation of protein modification process GO:0031401 107 78 5,000 1,227E-04 5,225E-03 ! negative regulation of cell motion GO:0051271 104 51 4,000 1,456E-04 6,088E-03 ! plasma membrane organization GO:0007009 18 11 2,000 1,482E-04 6,088E-03 ! chondrocyte differentiation GO:0002062 17 11 2,000 1,482E-04 5,982E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 1,482E-04 5,878E-03 GO:0042130|negative regulation of T cell proliferation, ! positive regulation of MAP kinase activity GO:0043406 121 85 5,000 1,973E-04 7,691E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 5,000 2,104E-04 8,065E-03 ! interphase GO:0051325 159 88 5,000 2,386E-04 8,996E-03 ! negative regulation of cell adhesion GO:0007162 67 33 3,000 3,029E-04 0,01123729 ! androgen receptor signaling pathway GO:0030521 54 33 3,000 3,029E-04 0,01105892 ! negative regulation of bone remodeling GO:0046851 26 14 2,000 3,199E-04 0,01149806 ! inositol metabolic process GO:0006020 20 14 2,000 3,199E-04 0,01132116 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 3,222E-04 0,01122856 ! angiogenesis GO:0001525 149 95 5,000 3,615E-04 0,01240834 ! negative regulation of cell growth GO:0030308 106 62 4,000 3,674E-04 0,01242665 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 3,959E-04 0,01319692 ! negative regulation of cell cycle process GO:0010948 24 15 2,000 3,97E-04 0,01304525 ! embryonic forelimb morphogenesis GO:0035115 17 15 2,000 3,97E-04 0,01286152 ! cardiac muscle tissue development GO:0048738 23 15 2,000 3,97E-04 0,01268289 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 3,97E-04 0,01250915 ! negative regulation of tissue remodeling GO:0034104 27 15 2,000 3,97E-04 0,01234011 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 3,97E-04 0,01217557 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of cell size GO:0045792 108 64 4,000 4,261E-04 0,01289385 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 4,000 4,261E-04 0,01272639 ! regulation of caspase activity GO:0043281 97 65 4,000 4,579E-04 0,0135024 ! protein oligomerization GO:0051259 100 65 4,000 4,579E-04 0,01333148 ! endothelial cell migration GO:0043542 22 16 2,000 4,851E-04 0,01394681 ! fructose metabolic process GO:0006000 20 16 2,000 4,851E-04 0,01377463 ! neutrophil chemotaxis GO:0030593 21 16 2,000 4,851E-04 0,01360664 ! detection of biotic stimulus GO:0009595 19 16 2,000 4,851E-04 0,01344271 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 4,851E-04 0,01328268 ! regulation of endopeptidase activity GO:0052548 99 67 4,000 5,27E-04 0,01425872 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 5,848E-04 0,01563963 ! forelimb morphogenesis GO:0035136 19 17 2,000 5,848E-04 0,01545986 ! inactivation of MAPK activity GO:0000188 27 17 2,000 5,848E-04 0,01528418 ! cell-substrate junction assembly GO:0007044 39 17 2,000 5,848E-04 0,01511245 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 5,848E-04 0,01494453 ! activation of protein kinase activity GO:0032147 102 69 4,000 6,035E-04 0,01525441 ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 6,411E-04 0,01602649 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 6,967E-04 0,01722914 ! response to retinoic acid GO:0032526 25 18 2,000 6,967E-04 0,01704585 ! negative regulation of T cell activation GO:0050868 25 18 2,000 6,967E-04 0,01686642 ! regulation of peptidase activity GO:0052547 106 72 4,000 7,337E-04 0,01757832 ! negative regulation of organelle organization GO:0010639 115 72 4,000 7,337E-04 0,0173971 ! negative regulation of transport GO:0051051 116 73 4,000 7,814E-04 0,01833959 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 8,213E-04 0,01908038 GO:0010675|regulation of cellular carbohydrate metabolic process, ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 8,213E-04 0,01888958 ! response to vitamin A GO:0033189 26 19 2,000 8,213E-04 0,01870255 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 8,213E-04 0,01851919 ! regulation of gene-specific transcription GO:0032583 69 43 3,000 8,459E-04 0,01888999 ! negative regulation of growth GO:0045926 123 75 4,000 8,838E-04 0,01954505 ! glycolysis GO:0006096 53 44 3,000 9,234E-04 0,0202273 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 9,234E-04 0,02003648 ! negative regulation of bone resorption GO:0045779 10 5 1,000 9,548E-04 0,0205231 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 9,548E-04 0,02033307 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 9,548E-04 0,02014653 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 9,548E-04 0,01996338 ! cerebral cortex radially oriented cell migration GO:0021799 8 5 1,000 9,548E-04 0,01978353 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 1,000 9,548E-04 0,01960689 ! positive regulation of glycolysis GO:0045821 11 5 1,000 9,548E-04 0,01943338 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 9,548E-04 0,01926291 ! epithelial cell proliferation GO:0050673 6 5 1,000 9,548E-04 0,01909541 ! microvillus organization GO:0032528 7 5 1,000 9,548E-04 0,01893079 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 1,000 9,548E-04 0,01876899 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 1,000 9,548E-04 0,01860993 ! regulation of centrosome cycle GO:0046605 7 5 1,000 9,548E-04 0,01845354 ! regulation of respiratory burst GO:0060263 8 5 1,000 9,548E-04 0,01829976 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 9,548E-04 0,01814853 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 9,548E-04 0,01799977 GO:0022011|myelination in the peripheral nervous system, ! cellular anion homeostasis GO:0030002 6 5 1,000 9,548E-04 0,01785343 GO:0055081|anion homeostasis, ! response to vitamin GO:0033273 29 20 2,000 9,592E-04 0,01779201 ! hindlimb morphogenesis GO:0035137 32 20 2,000 9,592E-04 0,01764968 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 9,592E-04 0,0175096 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 9,592E-04 0,01737173 ! positive regulation of cell cycle GO:0045787 77 45 3,000 1,006E-03 0,01807227 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 1,006E-03 0,01793217 ! response to UV GO:0009411 75 46 3,000 1,093E-03 0,01933996 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 1,111E-03 0,01950596 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 1,111E-03 0,01935818 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 1,111E-03 0,01921263 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 1,186E-03 0,0203513 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of cell cycle process GO:0010564 122 81 4,000 1,251E-03 0,0213138 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 1,277E-03 0,02159808 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 1,277E-03 0,02144043 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 1,277E-03 0,02128506 ! protein tetramerization GO:0051262 39 22 2,000 1,277E-03 0,02113193 ! regulation of DNA replication GO:0006275 75 48 3,000 1,284E-03 0,0210876 ! regulation of angiogenesis GO:0045765 94 49 3,000 1,387E-03 0,0226251 ! regulation of cell adhesion GO:0030155 159 83 4,000 1,395E-03 0,02260131 ! positive regulation of protein ubiquitination GO:0031398 8 6 1,000 1,423E-03 0,02288479 ! positive regulation of DNA repair GO:0045739 7 6 1,000 1,423E-03 0,02272587 ! regulation of helicase activity GO:0051095 11 6 1,000 1,423E-03 0,02256914 ! prostate gland development GO:0030850 9 6 1,000 1,423E-03 0,02241456 ! male meiosis GO:0007140 7 6 1,000 1,423E-03 0,02226208 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,423E-03 0,02211166 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,423E-03 0,02196326 ! mRNA stabilization GO:0048255 15 6 1,000 1,423E-03 0,02181684 GO:0043489|RNA stabilization, ! negative regulation of endocytosis GO:0045806 8 6 1,000 1,423E-03 0,02167235 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,423E-03 0,02152977 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 1,000 1,423E-03 0,02138906 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,423E-03 0,02125017 ! male sex determination GO:0030238 9 6 1,000 1,423E-03 0,02111307 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 1,423E-03 0,02097773 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 1,423E-03 0,02084411 ! astrocyte development GO:0014002 14 6 1,000 1,423E-03 0,02071219 ! Schwann cell development GO:0014044 14 6 1,000 1,423E-03 0,02058192 ! neutrophil homeostasis GO:0001780 6 6 1,000 1,423E-03 0,02045328 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,423E-03 0,02032625 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,423E-03 0,02020078 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 1,423E-03 0,02007684 ! myelination GO:0042552 35 23 2,000 1,458E-03 0,02044824 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 1,458E-03 0,02032431 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 1,458E-03 0,02020187 ! microtubule cytoskeleton organization GO:0000226 120 84 4,000 1,472E-03 0,02027305 ! negative regulation of cytoskeleton organization GO:0051494 84 50 3,000 1,496E-03 0,02048256 ! lipid modification GO:0030258 73 50 3,000 1,496E-03 0,02036137 ! positive regulation of growth GO:0045927 67 50 3,000 1,496E-03 0,02024159 ! regulation of DNA metabolic process GO:0051052 135 85 4,000 1,552E-03 0,0208704 ! positive regulation of cell migration GO:0030335 92 51 3,000 1,611E-03 0,02154321 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,866E-03 0,02481207 ! reproductive developmental process GO:0003006 127 89 4,000 1,902E-03 0,02514596 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 1,000 1,979E-03 0,02601 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 1,979E-03 0,02586221 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,979E-03 0,0257161 ! pericardium development GO:0060039 8 7 1,000 1,979E-03 0,02557163 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,979E-03 0,02542877 ! cerebral cortex cell migration GO:0021795 11 7 1,000 1,979E-03 0,0252875 ! microtubule bundle formation GO:0001578 8 7 1,000 1,979E-03 0,02514779 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,979E-03 0,02500961 ! protein heterooligomerization GO:0051291 10 7 1,000 1,979E-03 0,02487295 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,979E-03 0,02473777 ! B cell lineage commitment GO:0002326 17 7 1,000 1,979E-03 0,02460405 ! regulation of fat cell differentiation GO:0045598 9 7 1,000 1,979E-03 0,02447177 ! T cell lineage commitment GO:0002360 12 7 1,000 1,979E-03 0,02434091 ! response to tumor cell GO:0002347 12 7 1,000 1,979E-03 0,02421143 ! regulation of synaptogenesis GO:0051963 10 7 1,000 1,979E-03 0,02408333 ! glucose catabolic process GO:0006007 66 54 3,000 1,993E-03 0,02411991 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 2,094E-03 0,02522166 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 2,094E-03 0,02509029 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 2,094E-03 0,02496029 ! mesoderm development GO:0007498 76 55 3,000 2,132E-03 0,02528116 ! negative regulation of response to stimulus GO:0048585 80 56 3,000 2,279E-03 0,02687985 ! positive regulation of cell motion GO:0051272 99 56 3,000 2,279E-03 0,02674271 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 2,339E-03 0,02731159 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 2,593E-03 0,03011541 ! cell junction assembly GO:0034329 56 28 2,000 2,601E-03 0,03006308 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 2,601E-03 0,02991276 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 2,601E-03 0,02976394 ! ensheathment of neurons GO:0007272 43 28 2,000 2,601E-03 0,0296166 GO:0008366|axon ensheathment, ! positive regulation of catabolic process GO:0009896 40 28 2,000 2,601E-03 0,0294707 ! regulation of B cell activation GO:0050864 42 28 2,000 2,601E-03 0,02932624 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 2,622E-03 0,02941255 ! cell proliferation in forebrain GO:0021846 10 8 1,000 2,622E-03 0,02926977 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,622E-03 0,02912837 ! succinate metabolic process GO:0006105 14 8 1,000 2,622E-03 0,02898833 ! astrocyte differentiation GO:0048708 16 8 1,000 2,622E-03 0,02884963 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 2,622E-03 0,02871225 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,622E-03 0,02857618 ! regulation of Notch signaling pathway GO:0008593 18 8 1,000 2,622E-03 0,02844138 ! Schwann cell differentiation GO:0014037 17 8 1,000 2,622E-03 0,02830786 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 1,000 2,622E-03 0,02817558 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 1,000 2,622E-03 0,02804453 ! myeloid cell homeostasis GO:0002262 8 8 1,000 2,622E-03 0,02791469 ! regulation of embryonic development GO:0045995 16 8 1,000 2,622E-03 0,02778605 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 2,622E-03 0,02765859 ! regulation of cellular component biogenesis GO:0044087 158 96 4,000 2,651E-03 0,02783787 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 2,935E-03 0,03067943 ! meiosis GO:0007126 96 61 3,000 3,117E-03 0,03243516 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 3,000 3,117E-03 0,03228906 ! spindle organization GO:0007051 37 30 2,000 3,177E-03 0,03277018 ! regulation of microtubule-based process GO:0032886 58 30 2,000 3,177E-03 0,03262388 ! negative regulation of cell activation GO:0050866 44 30 2,000 3,177E-03 0,03247889 ! meiotic cell cycle GO:0051321 97 62 3,000 3,306E-03 0,03364713 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 3,349E-03 0,03392946 ! telencephalon cell migration GO:0022029 16 9 1,000 3,349E-03 0,03378064 ! SMAD protein nuclear translocation GO:0007184 15 9 1,000 3,349E-03 0,03363313 ! regulation of glycolysis GO:0006110 15 9 1,000 3,349E-03 0,0334869 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 1,000 3,349E-03 0,03334193 ! lung alveolus development GO:0048286 17 9 1,000 3,349E-03 0,03319822 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 3,349E-03 0,03305574 ! L-serine metabolic process GO:0006563 13 9 1,000 3,349E-03 0,03291447 ! phosphagen metabolic process GO:0006599 12 9 1,000 3,349E-03 0,03277441 GO:0006600|creatine metabolic process, ! DNA ligation GO:0006266 14 9 1,000 3,349E-03 0,03263554 ! postreplication repair GO:0006301 11 9 1,000 3,349E-03 0,03249783 ! regulation of synapse organization GO:0050807 12 9 1,000 3,349E-03 0,03236129 ! localization within membrane GO:0051668 15 9 1,000 3,349E-03 0,03222589 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 3,492E-03 0,03346847 ! leukocyte chemotaxis GO:0030595 43 31 2,000 3,492E-03 0,03332959 GO:0060326|cell chemotaxis, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 3,504E-03 0,03329776 ! cell cycle checkpoint GO:0000075 108 64 3,000 3,709E-03 0,03510261 ! hexose catabolic process GO:0019320 82 64 3,000 3,709E-03 0,03495874 ! regulation of muscle development GO:0048634 48 32 2,000 3,826E-03 0,03591652 ! peripheral nervous system development GO:0007422 53 32 2,000 3,826E-03 0,03577051 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 2,000 3,826E-03 0,03562569 ! reproductive structure development GO:0048608 90 65 3,000 3,922E-03 0,03637182 ! axon guidance GO:0007411 99 66 3,000 4,143E-03 0,03826998 ! negative regulation of muscle development GO:0048635 12 10 1,000 4,159E-03 0,03826016 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 4,159E-03 0,03810772 ! blood vessel remodeling GO:0001974 21 10 1,000 4,159E-03 0,0379565 ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 4,159E-03 0,03780648 ! pathogenesis GO:0009405 13 10 1,000 4,159E-03 0,03765763 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 4,159E-03 0,03750996 ! response to X-ray GO:0010165 16 10 1,000 4,159E-03 0,03736343 ! forebrain cell migration GO:0021885 17 10 1,000 4,159E-03 0,03721805 ! negative regulation of ossification GO:0030279 19 10 1,000 4,159E-03 0,03707379 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 4,159E-03 0,03693065 ! regulation of bone resorption GO:0045124 24 10 1,000 4,159E-03 0,03678861 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 4,159E-03 0,03664766 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 4,159E-03 0,03650778 GO:0043470|regulation of carbohydrate catabolic process, ! regulation of synapse structure and activity GO:0050803 13 10 1,000 4,159E-03 0,03636897 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 4,178E-03 0,03640087 ! cell junction organization GO:0034330 63 33 2,000 4,178E-03 0,03626351 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 2,000 4,55E-03 0,03933829 ! neuron migration GO:0001764 46 34 2,000 4,55E-03 0,03919096 ! polyol metabolic process GO:0019751 44 34 2,000 4,55E-03 0,03904472 ! regulation of intracellular protein transport GO:0033157 59 35 2,000 4,94E-03 0,04224046 ! regulation of action potential in neuron GO:0019228 54 35 2,000 4,94E-03 0,04208402 ! glycogen metabolic process GO:0005977 48 35 2,000 4,94E-03 0,04192872 ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 1,000 5,05E-03 0,04270161 ! virus-host interaction GO:0019048 17 11 1,000 5,05E-03 0,04254519 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 5,05E-03 0,04238992 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 5,05E-03 0,04223577 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 1,000 5,05E-03 0,04208274 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 5,05E-03 0,04193082 ! focal adhesion formation GO:0048041 24 11 1,000 5,05E-03 0,04177999 ! regulation of intracellular pH GO:0051453 17 11 1,000 5,05E-03 0,04163024 ! nucleoside triphosphate catabolic process GO:0009143 15 11 1,000 5,05E-03 0,04148156 ! regulation of leukocyte migration GO:0002685 24 11 1,000 5,05E-03 0,04133394 ! serine family amino acid biosynthetic process GO:0009070 13 11 1,000 5,05E-03 0,04118737 ! tissue remodeling GO:0048771 62 36 2,000 5,351E-03 0,04348608 ! glucan metabolic process GO:0044042 49 36 2,000 5,351E-03 0,04333296 GO:0006073|cellular glucan metabolic process, ! steroid biosynthetic process GO:0006694 94 71 3,000 5,377E-03 0,0433919 ! monosaccharide catabolic process GO:0046365 91 71 3,000 5,377E-03 0,04324018 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 6,021E-03 0,04824929 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 6,021E-03 0,04808176 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 6,021E-03 0,04791538 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 6,021E-03 0,04775016 ! peptidyl-lysine modification GO:0018205 18 12 1,000 6,021E-03 0,04758607 ! response to gamma radiation GO:0010332 20 12 1,000 6,021E-03 0,0474231 ! regulation of mRNA stability GO:0043488 27 12 1,000 6,021E-03 0,04726125 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 6,021E-03 0,0471005 ! microspike assembly GO:0030035 23 12 1,000 6,021E-03 0,04694083 ! regulation of T cell proliferation GO:0042129 58 38 2,000 6,231E-03 0,04841973 ! negative regulation of protein complex disassembly GO:0043242 67 39 2,000 6,702E-03 0,05190289 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 6,702E-03 0,05172872 ! male sex differentiation GO:0046661 53 39 2,000 6,702E-03 0,05155571 ! regulation of cell morphogenesis GO:0022604 140 76 3,000 6,835E-03 0,05240029 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 7,069E-03 0,0540179 ! lipid localization GO:0010876 24 13 1,000 7,069E-03 0,05383903 GO:0019915|lipid storage, ! regulation of DNA repair GO:0006282 15 13 1,000 7,069E-03 0,05366135 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 7,069E-03 0,05348483 ! regulation of cellular pH GO:0030641 20 13 1,000 7,069E-03 0,05330947 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 7,069E-03 0,05313525 ! regulation of RNA stability GO:0043487 28 13 1,000 7,069E-03 0,05296218 ! gland development GO:0048732 148 77 3,000 7,155E-03 0,05342845 ! sex differentiation GO:0007548 105 77 3,000 7,155E-03 0,05325555 ! T cell differentiation GO:0030217 65 40 2,000 7,194E-03 0,05337254 ! double-strand break repair GO:0006302 67 40 2,000 7,194E-03 0,05320092 ! positive regulation of protein transport GO:0051222 55 40 2,000 7,194E-03 0,05303041 ! energy reserve metabolic process GO:0006112 59 41 2,000 7,706E-03 0,05662527 ! regulation of T cell differentiation GO:0045580 59 41 2,000 7,706E-03 0,05644494 ! alcohol catabolic process GO:0046164 104 80 3,000 8,174E-03 0,05967962 ! forebrain development GO:0030900 131 80 3,000 8,174E-03 0,05949076 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 8,194E-03 0,05945312 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 8,194E-03 0,05926616 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 8,194E-03 0,05908038 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 8,194E-03 0,05889575 ! heterophilic cell adhesion GO:0007157 29 14 1,000 8,194E-03 0,05871227 ! limbic system development GO:0021761 25 14 1,000 8,194E-03 0,05852994 ! pituitary gland development GO:0021983 23 14 1,000 8,194E-03 0,05834873 ! cellular response to starvation GO:0009267 21 14 1,000 8,194E-03 0,05816864 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 8,194E-03 0,05798966 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 8,194E-03 0,05781178 ! G1/S transition checkpoint GO:0031575 33 14 1,000 8,194E-03 0,05763498 ! DNA unwinding during replication GO:0006268 21 14 1,000 8,194E-03 0,05745927 ! muscle maintenance GO:0046716 19 14 1,000 8,194E-03 0,05728462 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 8,194E-03 0,05711103 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 8,194E-03 0,05693849 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 2,000 8,239E-03 0,05707916 ! regulation of gene expression, epigenetic GO:0040029 72 42 2,000 8,239E-03 0,05690775 ! regulation of cell shape GO:0008360 78 42 2,000 8,239E-03 0,05673737 ! hemostasis GO:0007599 125 81 3,000 8,533E-03 0,05858562 ! leukocyte migration GO:0050900 60 43 2,000 8,794E-03 0,06019532 ! activation of caspase activity GO:0006919 65 43 2,000 8,794E-03 0,0600167 ! DNA-dependent DNA replication GO:0006261 59 43 2,000 8,794E-03 0,05983914 ! regulation of action potential GO:0001508 71 44 2,000 9,37E-03 0,06356976 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 9,37E-03 0,06338279 ! regulation of inflammatory response GO:0050727 60 44 2,000 9,37E-03 0,06319691 ! regulation of protein ubiquitination GO:0031396 19 15 1,000 9,394E-03 0,06317437 ! embryonic hindlimb morphogenesis GO:0035116 25 15 1,000 9,394E-03 0,06299019 ! lipid phosphorylation GO:0046834 23 15 1,000 9,394E-03 0,06280708 ! centrosome cycle GO:0007098 16 15 1,000 9,394E-03 0,06262503 ! positive regulation of proteolysis GO:0045862 19 15 1,000 9,394E-03 0,06244403 ! cerebral cortex development GO:0021987 29 15 1,000 9,394E-03 0,06226408 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 9,394E-03 0,06208516 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 9,394E-03 0,06190727 ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 9,394E-03 0,06173039 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 9,394E-03 0,06155452 ! positive regulation of defense response GO:0031349 59 45 2,000 9,967E-03 0,0651256 ! cell cycle arrest GO:0007050 150 86 3,000 0,01048642 0,06832513 ! regulation of protein complex disassembly GO:0043244 77 46 2,000 0,01058616 0,06878013 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 0,01066642 0,06910637 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 0,01066642 0,06891226 ! DNA replication initiation GO:0006270 25 16 1,000 0,01066642 0,06871922 ! diencephalon development GO:0021536 25 16 1,000 0,01066642 0,06852727 ! G1 phase GO:0051318 27 16 1,000 0,01066642 0,06833639 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 0,01066642 0,06814656 ! negative regulation of translation GO:0017148 22 16 1,000 0,01066642 0,06795779 ! bone remodeling GO:0046849 24 16 1,000 0,01066642 0,06777006 ! protein amino acid acetylation GO:0006473 28 16 1,000 0,01066642 0,06758337 ! glial cell development GO:0021782 24 16 1,000 0,01066642 0,0673977 ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 0,01090888 0,06874088 ! negative regulation of immune system process GO:0002683 73 47 2,000 0,0112271 0,07055282 ! positive regulation of caspase activity GO:0043280 72 48 2,000 0,01189 0,07451499 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 2,000 0,01189 0,07431251 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 0,01189 0,07411112 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 0,01189 0,07391082 ! zinc ion transport GO:0006829 20 17 1,000 0,01201064 0,07445947 ! memory GO:0007613 25 17 1,000 0,01201064 0,07425931 ! DNA duplex unwinding GO:0032508 25 17 1,000 0,01201064 0,07406022 GO:0032392|DNA geometric change, ! actin filament bundle formation GO:0051017 26 17 1,000 0,01201064 0,0738622 ! neuromuscular junction development GO:0007528 23 17 1,000 0,01201064 0,07366524 ! peptidyl-serine modification GO:0018209 27 17 1,000 0,01201064 0,07346932 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 0,01201064 0,07327444 ! positive regulation of synaptic transmission GO:0050806 24 17 1,000 0,01201064 0,07308059 ! regulation of intracellular transport GO:0032386 78 49 2,000 0,01257498 0,07631253 ! cartilage development GO:0051216 70 49 2,000 0,01257498 0,07611171 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 0,01318563 0,07959826 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 0,01328214 0,079971 ! positive regulation of DNA replication GO:0045740 29 18 1,000 0,01342488 0,08061941 ! pigmentation during development GO:0048066 31 18 1,000 0,01342488 0,08040946 ! peptide cross-linking GO:0018149 31 18 1,000 0,01342488 0,0802006 ! somitogenesis GO:0001756 24 18 1,000 0,01342488 0,07999283 ! cellular response to nutrient levels GO:0031669 27 18 1,000 0,01342488 0,07978613 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 1,000 0,01342488 0,0795805 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 0,01342488 0,07937592 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 0,01342488 0,07917239 ! regulation of cytoskeleton organization GO:0051493 154 93 3,000 0,01367452 0,08043834 ! carbohydrate catabolic process GO:0016052 121 93 3,000 0,01367452 0,08023314 ! aging GO:0007568 79 52 2,000 0,01476339 0,08640154 ! nucleotide-excision repair GO:0006289 64 52 2,000 0,01476339 0,08618225 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,01490766 0,0868041 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 0,01490766 0,08658489 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 0,01490766 0,0863668 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 0,01490766 0,08614979 ! apoptotic nuclear changes GO:0030262 24 19 1,000 0,01490766 0,08593388 ! response to starvation GO:0042594 30 19 1,000 0,01490766 0,08571904 ! plasma membrane fusion GO:0045026 23 19 1,000 0,01490766 0,08550528 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 0,01490766 0,08529258 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 0,01490766 0,08508094 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 0,01490766 0,08487034 ! positive regulation of neurological system process GO:0031646 28 19 1,000 0,01490766 0,08466078 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 0,01490766 0,08445226 ! regulation of response to external stimulus GO:0032101 139 96 3,000 0,01520984 0,08595244 ! in utero embryonic development GO:0001701 147 96 3,000 0,01520984 0,08574177 ! response to light stimulus GO:0009416 153 96 3,000 0,01520984 0,08553213 ! regulation of bone remodeling GO:0046850 90 53 2,000 0,01553765 0,08716243 ! cell projection assembly GO:0030031 76 53 2,000 0,01553765 0,08695036 ! regulation of mitosis GO:0007088 84 54 2,000 0,01633442 0,09118732 GO:0051783|regulation of nuclear division, ! detection of external stimulus GO:0009581 66 54 2,000 0,01633442 0,09096653 ! regulation of tissue remodeling GO:0034103 91 54 2,000 0,01633442 0,0907468 ! regulation of ARF GTPase activity GO:0032312 31 20 1,000 0,01645749 0,09121017 ! pallium development GO:0021543 38 20 1,000 0,01645749 0,09099091 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01645749 0,09077271 ! regulation of body fluid levels GO:0050878 154 100 3,000 0,01742009 0,09585219 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 0,01799574 0,09878331 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01807291 0,09897068 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 0,01807291 0,0987356 ! protein amino acid acylation GO:0043543 37 21 1,000 0,01807291 0,09850163 ! dendrite development GO:0016358 35 21 1,000 0,01807291 0,09826876 ! cell aging GO:0007569 32 21 1,000 0,01807291 0,098037 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01807291 0,09780632 ! platelet activation GO:0030168 28 21 1,000 0,01807291 0,09757673 ! regulation of bone mineralization GO:0030500 29 21 1,000 0,01807291 0,09734821 ! chromosome segregation GO:0007059 83 57 2,000 0,01886038 0,10135251 ! gonad development GO:0008406 79 57 2,000 0,01886038 0,10111626 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01975249 0,10565284 ! leukocyte adhesion GO:0007159 38 22 1,000 0,01975249 0,1054077 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01975249 0,10516371 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01975249 0,10492083 GO:0051297|centrosome organization, ! barbed-end actin filament capping GO:0051016 33 22 1,000 0,01975249 0,10467908 GO:0051693|actin filament capping, ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01975249 0,10443844 ! neural tube closure GO:0001843 33 22 1,000 0,01975249 0,1041989 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! lung development GO:0030324 94 59 2,000 0,02065778 0,10872514 ! activation of MAPK activity GO:0000187 84 59 2,000 0,02065778 0,10847691 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,02149481 0,1126152 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,02149481 0,11235926 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,02149481 0,11210448 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,02149481 0,11185085 ! interaction with host GO:0051701 37 23 1,000 0,02149481 0,11159836 ! regulation of biomineral formation GO:0070167 31 23 1,000 0,02149481 0,11134701 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 0,02159058 0,11159175 GO:0035113|embryonic appendage morphogenesis, ! regulation of heart contraction GO:0008016 91 60 2,000 0,02159058 0,11134155 ! cell-matrix adhesion GO:0007160 114 61 2,000 0,02254613 0,11600916 ! negative regulation of ligase activity GO:0051352 91 61 2,000 0,02254613 0,11575021 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,0232985 0,11934643 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,0232985 0,11908121 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,0232985 0,11881718 ! response to toxin GO:0009636 38 24 1,000 0,0232985 0,11855431 ! primary neural tube formation GO:0014020 35 24 1,000 0,0232985 0,1182926 ! negative regulation of cell development GO:0010721 56 24 1,000 0,0232985 0,11803204 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 0,0232985 0,11777263 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,0232985 0,11751436 ! respiratory tube development GO:0030323 99 62 2,000 0,02352443 0,11839429 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,02452548 0,12316287 GO:0090046|regulation of transcription regulator activity, ! negative regulation of actin filament depolymerization GO:0030835 36 25 1,000 0,02516217 0,12608494 ! negative regulation of actin filament polymerization GO:0030837 36 25 1,000 0,02516217 0,12581084 ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 0,02516217 0,12553793 ! male gonad development GO:0008584 33 25 1,000 0,02516217 0,1252662 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,02516217 0,12499565 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,02516217 0,12472626 GO:0045840|positive regulation of mitosis, ! appendage morphogenesis GO:0035107 93 64 2,000 0,02554925 0,12637266 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 2,000 0,02554925 0,12610147 ! appendage development GO:0048736 94 65 2,000 0,02659574 0,13098546 GO:0060173|limb development, ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,02708447 0,13310746 ! regulation of pH GO:0006885 36 26 1,000 0,02708447 0,13282365 ! post-embryonic development GO:0009791 42 26 1,000 0,02708447 0,13254104 ! negative regulation of protein polymerization GO:0032272 38 26 1,000 0,02708447 0,13225964 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,02766491 0,13480784 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 0,02906409 0,14132643 ! acute-phase response GO:0006953 42 27 1,000 0,02906409 0,14102828 ! response to ionizing radiation GO:0010212 47 27 1,000 0,02906409 0,14073137 ! serine family amino acid metabolic process GO:0009069 37 27 1,000 0,02906409 0,14043572 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,02906409 0,14014131 GO:0043433|negative regulation of transcription factor activity, ! learning or memory GO:0007611 123 68 2,000 0,02987116 0,14373154 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,02987116 0,14343147 ! response to drug GO:0042493 108 69 2,000 0,03100815 0,14858074 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,0310997 0,14870959 ! negative regulation of protein complex assembly GO:0031333 42 28 1,000 0,0310997 0,14840107 ! mesoderm formation GO:0001707 46 28 1,000 0,0310997 0,14809382 ! neural tube formation GO:0001841 41 28 1,000 0,0310997 0,14778784 ! eye development GO:0001654 111 70 2,000 0,03216765 0,15254764 ! regulation of catabolic process GO:0009894 106 70 2,000 0,03216765 0,15223375 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,03319003 0,15674961 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,03319003 0,1564284 ! formation of primary germ layer GO:0001704 48 29 1,000 0,03319003 0,15610851 ! telencephalon development GO:0021537 52 29 1,000 0,03319003 0,15578992 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,0333496 0,15622013 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 2,000 0,0333496 0,15590261 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,0333496 0,15558638 ! response to hypoxia GO:0001666 132 72 2,000 0,03455393 0,16087864 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,03533379 0,16417723 ! mitochondrion organization GO:0007005 104 73 2,000 0,03578058 0,16591802 ! response to oxygen levels GO:0070482 137 74 2,000 0,03702947 0,17136372 ! protein import into nucleus GO:0006606 118 74 2,000 0,03702947 0,17101962 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,03752975 0,17298284 ! mammary gland development GO:0030879 57 31 1,000 0,03752975 0,17263687 ! glial cell differentiation GO:0010001 55 31 1,000 0,03752975 0,17229229 ! segmentation GO:0035282 41 31 1,000 0,03752975 0,17194908 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,03752975 0,17160723 ! metanephros development GO:0001656 58 31 1,000 0,03752975 0,17126674 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,03752975 0,1709276 ! cell fate specification GO:0001708 37 31 1,000 0,03752975 0,1705898 ! blood coagulation GO:0007596 116 75 2,000 0,03830051 0,17374983 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 2,000 0,03830051 0,1734078 ! regulation of ligase activity GO:0051340 114 75 2,000 0,03830051 0,17306712 ! nuclear import GO:0051170 121 75 2,000 0,03830051 0,17272777 ! regulation of protein transport GO:0051223 114 76 2,000 0,03959362 0,17821002 GO:0070201|regulation of establishment of protein localization, ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,03977668 0,1786843 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,03977668 0,17833599 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,03977668 0,17798903 ! meiosis I GO:0007127 52 32 1,000 0,03977668 0,17764342 ! regulation of ARF protein signal transduction GO:0032012 51 32 1,000 0,03977668 0,17729915 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,03977668 0,17695621 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,03977668 0,1766146 ! regulation of DNA binding GO:0051101 119 77 2,000 0,04090871 0,18129099 ! sister chromatid segregation GO:0000819 46 33 1,000 0,04207336 0,18609369 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,04207336 0,18573651 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 1,000 0,04207336 0,18538069 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,04207336 0,18502623 ! nucleotide catabolic process GO:0009166 46 33 1,000 0,04207336 0,18467313 ! regulation of proteolysis GO:0030162 50 33 1,000 0,04207336 0,18432137 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,04207336 0,18397095 ! cytokinesis GO:0000910 52 33 1,000 0,04207336 0,18362186 ! T cell activation GO:0042110 134 79 2,000 0,04360443 0,18994352 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,04441859 0,19312432 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,04441859 0,19275993 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,04441859 0,19239692 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,04441859 0,19203527 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,04441859 0,19167498 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,04441859 0,19131604 ! protein localization in nucleus GO:0034504 133 80 2,000 0,04498485 0,19339282 ! Notch signaling pathway GO:0007219 56 35 1,000 0,04681122 0,20086903 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,04681122 0,20049497 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,04681122 0,20012231 ! ossification GO:0001503 134 82 2,000 0,04781028 0,20401418 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 2,000 0,04781028 0,20363638 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04851526 0,20625712 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04851526 0,20587657 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04851526 0,20549742 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,04851526 0,20511967 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04851526 0,20474331 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04851526 0,20436832 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04851526 0,2039947 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04851526 0,20362245 ! sleep GO:0030431 11 5 0,000 0,04851526 0,20325155 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04851526 0,202882 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04851526 0,2025138 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04851526 0,20214692 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04851526 0,20178138 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04851526 0,20141715 ! tongue development GO:0043586 6 5 0,000 0,04851526 0,20105424 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04851526 0,20069263 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04851526 0,20033232 ! cobalt ion transport GO:0006824 9 5 0,000 0,04851526 0,1999733 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04851526 0,19961557 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04851526 0,19925911 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04851526 0,19890392 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04851526 0,19855 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04851526 0,19819734 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04851526 0,19784592 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04851526 0,19749575 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04851526 0,19714682 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04851526 0,19679912 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04851526 0,19645264 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04851526 0,19610738 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04851526 0,19576334 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04851526 0,19542049 ! malate metabolic process GO:0006108 7 5 0,000 0,04851526 0,19507885 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04851526 0,1947384 ! behavioral response to pain GO:0048266 7 5 0,000 0,04851526 0,19439913 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04851526 0,19406105 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04851526 0,19372413 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04851526 0,19338839 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! mating behavior GO:0007617 6 5 0,000 0,04851526 0,19305381 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04851526 0,19272038 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04851526 0,19238811 ! rhythmic behavior GO:0007622 12 5 0,000 0,04851526 0,19205697 ! copulation GO:0007620 7 5 0,000 0,04851526 0,19172698 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04851526 0,19139812 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04851526 0,19107038 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04851526 0,19074376 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04851526 0,19041826 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04851526 0,19009387 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04851526 0,18977058 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04851526 0,18944839 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04851526 0,18912729 ! response to protozoan GO:0001562 9 5 0,000 0,04851526 0,18880728 ! lymph vessel development GO:0001945 7 5 0,000 0,04851526 0,18848835 ! endochondral ossification GO:0001958 12 5 0,000 0,04851526 0,18817049 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04851526 0,18785371 ! parathyroid gland development GO:0060017 8 5 0,000 0,04851526 0,18753799 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04851526 0,18722332 ! anagen GO:0042640 6 5 0,000 0,04851526 0,18690972 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04851526 0,18659716 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04851526 0,18628565 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04851526 0,18597517 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04851526 0,18566573 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04851526 0,18535731 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04851526 0,18504992 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,04851526 0,18474355 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04851526 0,18443818 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04851526 0,18413383 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04851526 0,18383048 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,04851526 0,18352813 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04851526 0,18322677 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04851526 0,1829264 ! ovulation GO:0030728 6 5 0,000 0,04851526 0,18262701 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04851526 0,1823286 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 9 5 0,000 0,04851526 0,18203116 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04851526 0,18173469 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04851526 0,18143919 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04851526 0,18114465 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,04851526 0,18085106 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04851526 0,18055842 ! polyol catabolic process GO:0046174 7 5 0,000 0,04851526 0,18026672 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04851526 0,17997597 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04851526 0,17968615 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04851526 0,17939727 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04851526 0,17910931 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04851526 0,17882228 ! urea metabolic process GO:0019627 6 5 0,000 0,04851526 0,17853616 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04851526 0,17825096 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04851526 0,17796667 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04851526 0,17768328 ! neutrophil activation GO:0042119 5 5 0,000 0,04851526 0,1774008 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04851526 0,17711921 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04851526 0,17683851 ! response to food GO:0032094 5 5 0,000 0,04851526 0,1765587 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04851526 0,17627978 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04851526 0,17600174 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04851526 0,17572457 ! forebrain neuron development GO:0021884 7 5 0,000 0,04851526 0,17544827 ! melanosome organization GO:0032438 7 5 0,000 0,04851526 0,17517284 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04851526 0,17489828 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04851526 0,17462457 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04851526 0,17435172 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04851526 0,17407972 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,04851526 0,17380857 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04851526 0,17353826 ! nucleoside transport GO:0015858 6 5 0,000 0,04851526 0,17326879 ! nucleoside salvage GO:0043174 7 5 0,000 0,04851526 0,17300016 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04851526 0,17273236 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04851526 0,17246538 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04851526 0,17219923 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04851526 0,1719339 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04851526 0,17166939 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04851526 0,17140569 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04851526 0,17114279 ! depyrimidination GO:0045008 8 5 0,000 0,04851526 0,17088071 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04851526 0,17061942 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04851526 0,17035893 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04851526 0,17009924 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04851526 0,16984034 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,04851526 0,16958222 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,04851526 0,16932489 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04851526 0,16906834 ! monocyte differentiation GO:0030224 8 5 0,000 0,04851526 0,16881256 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04851526 0,16855755 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04851526 0,16830332 ! centrosome duplication GO:0051298 5 5 0,000 0,04851526 0,16804985 ! response to UV-C GO:0010225 6 5 0,000 0,04851526 0,16779714 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04851526 0,1675452 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04851526 0,16729401 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04851526 0,16704356 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04851526 0,16679387 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04851526 0,16654493 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04851526 0,16629672 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04851526 0,16604926 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04851526 0,16580253 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04851526 0,16555653 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04851526 0,16531126 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,04851526 0,16506672 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04851526 0,1648229 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04851526 0,1645798 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04851526 0,16433741 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04851526 0,16409574 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04851526 0,16385477 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04851526 0,16361452 ! neural tube patterning GO:0021532 6 5 0,000 0,04851526 0,16337497 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04851526 0,16313611 ! histone demethylation GO:0016577 9 5 0,000 0,04851526 0,16289796 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04851526 0,1626605 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04851526 0,16242373 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04851526 0,16218765 ! enteric nervous system development GO:0048484 8 5 0,000 0,04851526 0,16195225 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04851526 0,16171754 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04851526 0,1614835 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04851526 0,16125015 ! transcription termination GO:0006353 8 5 0,000 0,04851526 0,16101746 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04851526 0,16078545 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04851526 0,1605541 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04851526 0,16032342 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04851526 0,1600934 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04851526 0,15986404 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04851526 0,15963534 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04851526 0,15940729 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04851526 0,15917989 ! apical protein localization GO:0045176 6 5 0,000 0,04851526 0,15895314 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04851526 0,15872703 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04851526 0,15850156 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04851526 0,15827674 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04851526 0,15805255 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04851526 0,157829 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04851526 0,15760608 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,04851526 0,15738378 ! glial cell migration GO:0008347 10 5 0,000 0,04851526 0,15716211 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04851526 0,15694107 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,04851526 0,15672065 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04851526 0,15650084 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04851526 0,15628165 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04851526 0,15606308 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04851526 0,15584511 ! neural plate development GO:0001840 6 5 0,000 0,04851526 0,15562776 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04851526 0,155411 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04851526 0,15519486 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04851526 0,15497931 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,04851526 0,15476436 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04851526 0,15455 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04851526 0,15433624 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04851526 0,15412307 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04851526 0,15391048 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04851526 0,15369849 ! spindle assembly GO:0051225 5 5 0,000 0,04851526 0,15348707 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04851526 0,15327624 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04851526 0,15306598 ! organ regeneration GO:0031100 7 5 0,000 0,04851526 0,1528563 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04851526 0,1526472 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04851526 0,15243866 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04851526 0,1522307 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,04925007 0,15432584 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 52 36 1,000 0,04925007 0,15411587 ! negative regulation of binding GO:0051100 58 36 1,000 0,04925007 0,15390648 ! neural tube development GO:0021915 50 36 1,000 0,04925007 0,15369765 ! regulation of defense response GO:0031347 117 84 2,000 0,05072103 0,15807367 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,05173402 0,16101252 ! rRNA metabolic process GO:0016072 107 85 2,000 0,05220809 0,16226839 GO:0006364|rRNA processing, ! regulation of protein localization GO:0032880 132 85 2,000 0,05220809 0,1620494 ! regulation of membrane potential GO:0042391 128 85 2,000 0,05220809 0,16183101 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,05220809 0,1616132 ! gliogenesis GO:0042063 71 38 1,000 0,05426194 0,16774526 ! mesenchymal cell development GO:0014031 64 38 1,000 0,05426194 0,1675201 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 1,000 0,05426194 0,16729554 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,05524493 0,17009818 GO:0060538|skeletal muscle organ development, ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,05683274 0,17475308 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,05683274 0,17451976 ! JNK cascade GO:0007254 54 39 1,000 0,05683274 0,17428707 ! cell growth GO:0016049 61 39 1,000 0,05683274 0,17405499 ! synapse organization GO:0050808 55 39 1,000 0,05683274 0,17382354 ! tRNA transcription GO:0009304 11 6 0,000 0,05793375 0,17695567 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05793375 0,17672098 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05793375 0,17648691 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05793375 0,17625346 GO:0030816|positive regulation of cAMP metabolic process, ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05793375 0,17602063 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,05793375 0,17578841 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05793375 0,17555681 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05793375 0,17532581 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05793375 0,17509542 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05793375 0,17486564 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05793375 0,17463646 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05793375 0,17440788 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05793375 0,17417989 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05793375 0,1739525 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05793375 0,17372571 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05793375 0,1734995 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,05793375 0,17327388 ! neuron adhesion GO:0007158 9 6 0,000 0,05793375 0,17304885 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05793375 0,17282441 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05793375 0,17260054 ! signal peptide processing GO:0006465 8 6 0,000 0,05793375 0,17237725 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05793375 0,17215454 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05793375 0,17193241 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05793375 0,17171085 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05793375 0,17148985 ! opsonization GO:0008228 8 6 0,000 0,05793375 0,17126943 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05793375 0,17104957 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05793375 0,17083028 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05793375 0,17061154 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05793375 0,17039337 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05793375 0,17017576 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05793375 0,16995869 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05793375 0,16974219 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05793375 0,16952623 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05793375 0,16931082 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05793375 0,16909596 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05793375 0,16888164 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05793375 0,16866787 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05793375 0,16845464 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05793375 0,16824194 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05793375 0,16802978 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05793375 0,16781816 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05793375 0,16760706 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,05793375 0,1673965 ! thymic T cell selection GO:0045061 12 6 0,000 0,05793375 0,16718647 ! protein lipoylation GO:0009249 10 6 0,000 0,05793375 0,16697696 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05793375 0,16676798 ! pigment granule organization GO:0048753 11 6 0,000 0,05793375 0,16655952 ! drug transport GO:0015893 6 6 0,000 0,05793375 0,16635158 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05793375 0,16614416 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05793375 0,16593726 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05793375 0,16573087 ! histidine metabolic process GO:0006547 6 6 0,000 0,05793375 0,16552499 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05793375 0,16531962 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,05793375 0,16511477 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! glycine catabolic process GO:0006546 9 6 0,000 0,05793375 0,16491042 ! adenohypophysis development GO:0021984 10 6 0,000 0,05793375 0,16470657 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05793375 0,16450323 ! hyperosmotic response GO:0006972 8 6 0,000 0,05793375 0,16430039 ! microtubule nucleation GO:0007020 10 6 0,000 0,05793375 0,16409805 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05793375 0,16389621 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05793375 0,16369486 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05793375 0,16349401 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,05793375 0,16329365 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,05793375 0,16309378 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,05793375 0,1628944 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05793375 0,1626955 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,05793375 0,16249709 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05793375 0,16229917 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,05793375 0,16210172 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,05793375 0,16190476 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,05793375 0,16170827 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05793375 0,16151226 ! neuron apoptosis GO:0051402 8 6 0,000 0,05793375 0,16131673 ! organic alcohol transport GO:0015850 9 6 0,000 0,05793375 0,16112166 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,05793375 0,16092707 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05793375 0,16073295 ! carnitine transport GO:0015879 8 6 0,000 0,05793375 0,1605393 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05793375 0,16034611 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05793375 0,16015339 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05793375 0,15996112 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05793375 0,15976932 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05793375 0,15957798 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,05793375 0,1593871 ! parturition GO:0007567 12 6 0,000 0,05793375 0,15919667 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05793375 0,1590067 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05793375 0,15881718 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05793375 0,15862811 ! spindle checkpoint GO:0031577 14 6 0,000 0,05793375 0,1584395 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05793375 0,15825133 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05793375 0,1580636 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05793375 0,15787632 ! macrophage differentiation GO:0030225 10 6 0,000 0,05793375 0,15768949 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05793375 0,15750309 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05793375 0,15731714 ! interaction with symbiont GO:0051702 8 6 0,000 0,05793375 0,15713162 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05793375 0,15694654 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05793375 0,1567619 ! eating behavior GO:0042755 6 6 0,000 0,05793375 0,15657769 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05793375 0,15639392 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05793375 0,15621057 ! response to copper ion GO:0046688 9 6 0,000 0,05793375 0,15602765 ! DNA topological change GO:0006265 8 6 0,000 0,05793375 0,15584517 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05793375 0,1556631 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,05793375 0,15548147 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05793375 0,15530025 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05793375 0,15511946 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05793375 0,15493909 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05793375 0,15475914 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05793375 0,1545796 ! gas homeostasis GO:0033483 11 6 0,000 0,05793375 0,15440048 ! hair follicle maturation GO:0048820 7 6 0,000 0,05793375 0,15422178 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05793375 0,15404349 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05793375 0,15386561 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05793375 0,15368814 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,05793375 0,15351108 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05793375 0,15333443 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05793375 0,15315818 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,05793375 0,15298234 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05793375 0,1528069 ! histone ubiquitination GO:0016574 7 6 0,000 0,05793375 0,15263186 ! regulation of meiosis GO:0040020 10 6 0,000 0,05793375 0,15245723 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05793375 0,15228299 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05793375 0,15210915 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05793375 0,15193571 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05793375 0,15176266 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05793375 0,15159001 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05793375 0,15141775 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05793375 0,15124588 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05793375 0,1510744 ! receptor internalization GO:0031623 9 6 0,000 0,05793375 0,1509033 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05793375 0,1507326 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,05793375 0,15056228 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05793375 0,15039234 ! protein deubiquitination GO:0016579 8 6 0,000 0,05793375 0,15022279 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05793375 0,15005362 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05793375 0,14988483 ! axonal fasciculation GO:0007413 9 6 0,000 0,05793375 0,14971642 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05793375 0,14954839 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05793375 0,14938074 ! midbrain development GO:0030901 6 6 0,000 0,05793375 0,14921346 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05793375 0,14904655 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05793375 0,14888002 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05793375 0,14871386 ! progesterone metabolic process GO:0042448 8 6 0,000 0,05793375 0,14854807 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,05793375 0,14838265 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05793375 0,14821759 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05793375 0,14805291 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05793375 0,14788859 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05793375 0,14772463 ! adult feeding behavior GO:0008343 6 6 0,000 0,05793375 0,14756104 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05793375 0,14739781 ! blastocyst growth GO:0001832 15 6 0,000 0,05793375 0,14723494 ! pigment granule transport GO:0051904 12 6 0,000 0,05793375 0,14707242 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05793375 0,14691027 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05793375 0,14674848 ! catecholamine transport GO:0051937 7 6 0,000 0,05793375 0,14658704 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05793375 0,14642595 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05793375 0,14626522 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,05793375 0,14610484 ! protein prenylation GO:0018342 10 6 0,000 0,05793375 0,14594482 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05793375 0,14578514 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05793375 0,14562581 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05793375 0,14546683 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05793375 0,1453082 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,05836449 0,14622911 ! regulation of T cell activation GO:0050863 128 89 2,000 0,05836449 0,14606999 ! regulation of actin filament polymerization GO:0030833 59 40 1,000 0,05944532 0,1486133 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,05944532 0,14845194 ! B cell differentiation GO:0030183 62 40 1,000 0,05944532 0,14829093 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,05944532 0,14813027 ! leukocyte differentiation GO:0002521 143 90 2,000 0,05995493 0,14923847 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,06209862 0,15440738 ! glucose transport GO:0015758 52 41 1,000 0,06209862 0,15424064 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,06209862 0,15407425 ! cell fate commitment GO:0045165 141 92 2,000 0,06319641 0,15662903 ! sulfur metabolic process GO:0006790 118 92 2,000 0,06319641 0,15646043 ! mitochondrial transport GO:0006839 60 42 1,000 0,06479159 0,16023727 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,06479159 0,16006515 ! cellular component disassembly GO:0022411 64 42 1,000 0,06479159 0,15989341 ! hexose transport GO:0008645 54 42 1,000 0,06479159 0,15972203 GO:0015749|monosaccharide transport, ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,06484714 0,15968781 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,06725953 0,16545126 GO:0016446|somatic hypermutation of immunoglobulin genes, ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,06725953 0,1652745 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,06725953 0,16509811 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,06725953 0,1649221 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,06725953 0,16474646 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,06725953 0,1645712 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,06725953 0,16439631 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,06725953 0,16422179 ! reproductive behavior GO:0019098 12 7 0,000 0,06725953 0,16404764 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,06725953 0,16387386 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,06725953 0,16370045 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,06725953 0,16352741 ! oligopeptide transport GO:0006857 11 7 0,000 0,06725953 0,16335473 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,06725953 0,16318241 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,06725953 0,16301046 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,06725953 0,16283887 ! RNA methylation GO:0001510 11 7 0,000 0,06725953 0,16266764 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,06725953 0,16249677 ! fibril organization GO:0043206 13 7 0,000 0,06725953 0,16232626 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,06725953 0,16215611 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,06725953 0,16198631 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,06725953 0,16181687 ! lipoprotein transport GO:0042953 9 7 0,000 0,06725953 0,16164778 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,06725953 0,16147905 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,06725953 0,16131066 ! estrogen metabolic process GO:0008210 14 7 0,000 0,06725953 0,16114263 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,06725953 0,16097495 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,06725953 0,16080762 ! chemosensory behavior GO:0007635 9 7 0,000 0,06725953 0,16064063 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,06725953 0,16047399 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,06725953 0,1603077 ! leukocyte degranulation GO:0043299 10 7 0,000 0,06725953 0,16014175 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,06725953 0,15997614 ! reflex GO:0060004 12 7 0,000 0,06725953 0,15981088 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,06725953 0,15964595 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,06725953 0,15948137 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,06725953 0,15931712 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,06725953 0,15915322 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,06725953 0,15898965 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,06725953 0,15882641 ! spinal cord patterning GO:0021511 7 7 0,000 0,06725953 0,15866352 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,06725953 0,15850095 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,06725953 0,15833872 ! adrenal gland development GO:0030325 17 7 0,000 0,06725953 0,15817682 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,06725953 0,15801525 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,06725953 0,15785401 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,06725953 0,1576931 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,06725953 0,15753251 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,06725953 0,15737226 ! endosome organization GO:0007032 10 7 0,000 0,06725953 0,15721232 ! thyroid hormone generation GO:0006590 11 7 0,000 0,06725953 0,15705272 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,06725953 0,15689344 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,06725953 0,15673448 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,06725953 0,15657584 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,06725953 0,15641752 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,06725953 0,15625952 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,06725953 0,15610184 ! galactose metabolic process GO:0006012 10 7 0,000 0,06725953 0,15594448 ! vesicle fusion GO:0006906 15 7 0,000 0,06725953 0,15578744 ! intracellular pH reduction GO:0051452 10 7 0,000 0,06725953 0,15563071 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,06725953 0,1554743 ! organ growth GO:0035265 11 7 0,000 0,06725953 0,1553182 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,06725953 0,15516241 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,06725953 0,15500694 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,06725953 0,15485178 ! retinol metabolic process GO:0042572 9 7 0,000 0,06725953 0,15469693 ! behavioral fear response GO:0001662 13 7 0,000 0,06725953 0,15454239 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,06725953 0,15438815 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,06725953 0,15423423 ! rRNA modification GO:0000154 12 7 0,000 0,06725953 0,15408061 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,06725953 0,15392729 ! response to UV-B GO:0010224 11 7 0,000 0,06725953 0,15377428 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,06725953 0,15362158 ! intermediate filament organization GO:0045109 11 7 0,000 0,06725953 0,15346917 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,06725953 0,15331707 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,06725953 0,15316527 ! fibrinolysis GO:0042730 9 7 0,000 0,06725953 0,15301378 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,06725953 0,15286258 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,06725953 0,15271168 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,06725953 0,15256107 ! response to tropane GO:0014073 13 7 0,000 0,06725953 0,15241077 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! melanosome localization GO:0032400 10 7 0,000 0,06725953 0,15226076 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,06725953 0,15211104 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,06725953 0,15196162 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,06725953 0,15181249 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,06725953 0,15166365 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,06725953 0,15151511 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,06725953 0,15136686 ! mast cell activation GO:0045576 9 7 0,000 0,06725953 0,15121889 ! multicellular organismal aging GO:0010259 11 7 0,000 0,06725953 0,15107122 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,06725953 0,15092383 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,06725953 0,15077673 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,06725953 0,15062992 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,06725953 0,15048339 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,06725953 0,15033715 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,06725953 0,15019119 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,06725953 0,15004552 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,06725953 0,14990012 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,06725953 0,14975501 ! regulation of lipid transport GO:0032368 13 7 0,000 0,06725953 0,14961018 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,06725953 0,14946563 ! neuroblast proliferation GO:0007405 13 7 0,000 0,06725953 0,14932136 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,06725953 0,14917737 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,06725953 0,14903365 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,06725953 0,14889021 ! diuresis GO:0030146 12 7 0,000 0,06725953 0,14874705 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,06725953 0,14860416 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,06725953 0,14846154 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,06725953 0,1483192 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,06725953 0,14817713 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,06725953 0,14803534 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,06725953 0,14789381 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,06725953 0,14775256 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,06725953 0,14761157 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,06725953 0,14747086 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,06725953 0,14733041 ! lymph node development GO:0048535 9 7 0,000 0,06725953 0,14719023 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,06725953 0,14705031 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,06725953 0,14691066 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,06725953 0,14677128 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,06725953 0,14663216 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,06725953 0,1464933 ! ATP catabolic process GO:0006200 10 7 0,000 0,06725953 0,14635471 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,06725953 0,14621638 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,06725953 0,14607831 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,06725953 0,1459405 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,06725953 0,14580295 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,06725953 0,14566566 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,06725953 0,14552862 ! muscle adaptation GO:0043500 12 7 0,000 0,06725953 0,14539185 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,06725953 0,14525533 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,06725953 0,14511907 ! retina homeostasis GO:0001895 9 7 0,000 0,06725953 0,14498306 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,06725953 0,14484731 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,06725953 0,14471181 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,06725953 0,14457657 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,06725953 0,14444158 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,06725953 0,14430684 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,06725953 0,14417235 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,06725953 0,14403811 ! positive regulation of binding GO:0051099 59 43 1,000 0,06752319 0,14446822 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,06752319 0,14433396 ! regulation of binding GO:0051098 151 95 2,000 0,0682078 0,14566197 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,07029241 0,14997453 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,07029241 0,14983553 ! regulation of translational initiation GO:0006446 64 45 1,000 0,07309824 0,15567218 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,07309824 0,15552817 ! protein import GO:0017038 156 99 2,000 0,07516139 0,15977006 ! regulation of ossification GO:0030278 71 46 1,000 0,0759397 0,16127544 ! histone modification GO:0016570 68 46 1,000 0,0759397 0,16112667 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,07649353 0,16215219 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,07649353 0,16200287 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,07649353 0,16185384 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,07649353 0,16170507 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,07649353 0,16155659 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,07649353 0,16140837 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,07649353 0,16126042 ! phosphate transport GO:0006817 10 8 0,000 0,07649353 0,16111275 ! N-glycan processing GO:0006491 12 8 0,000 0,07649353 0,16096534 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,07649353 0,16081821 ! UTP metabolic process GO:0046051 8 8 0,000 0,07649353 0,16067134 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,07649353 0,16052475 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,07649353 0,16037841 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,07649353 0,16023235 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,07649353 0,16008655 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,07649353 0,15994102 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,07649353 0,15979575 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,07649353 0,15965075 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,07649353 0,159506 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,07649353 0,15936152 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,07649353 0,1592173 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,07649353 0,15907335 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,07649353 0,15892965 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,07649353 0,15878621 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,07649353 0,15864303 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,07649353 0,15850011 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,07649353 0,15835744 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,07649353 0,15821504 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,07649353 0,15807289 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,07649353 0,15793099 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,07649353 0,15778935 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,07649353 0,15764796 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,07649353 0,15750682 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,07649353 0,15736594 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,07649353 0,15722531 ! melanin metabolic process GO:0006582 12 8 0,000 0,07649353 0,15708493 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,07649353 0,1569448 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,07649353 0,15680492 ! macrophage activation GO:0042116 12 8 0,000 0,07649353 0,15666529 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,07649353 0,15652591 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,07649353 0,15638677 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,07649353 0,15624789 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,07649353 0,15610925 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,07649353 0,15597085 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,07649353 0,1558327 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,07649353 0,1556948 ! ruffle organization GO:0031529 11 8 0,000 0,07649353 0,15555714 ! osteoblast development GO:0002076 13 8 0,000 0,07649353 0,15541972 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,07649353 0,15528254 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,07649353 0,15514561 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,07649353 0,15500892 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,07649353 0,15487247 GO:0007351|tripartite regional subdivision, ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,07649353 0,15473625 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,07649353 0,15460028 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,07649353 0,15446455 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,07649353 0,15432905 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,07649353 0,1541938 ! oligodendrocyte development GO:0014003 8 8 0,000 0,07649353 0,15405878 ! segment specification GO:0007379 10 8 0,000 0,07649353 0,15392399 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,07649353 0,15378944 ! cellular extravasation GO:0045123 11 8 0,000 0,07649353 0,15365513 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,07649353 0,15352105 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,07649353 0,1533872 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,07649353 0,15325359 ! snRNA metabolic process GO:0016073 10 8 0,000 0,07649353 0,15312021 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,07649353 0,15298706 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,07649353 0,15285415 ! nucleosome disassembly GO:0006337 12 8 0,000 0,07649353 0,15272146 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,07649353 0,152589 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,07649353 0,15245678 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,07649353 0,15232478 ! icosanoid secretion GO:0032309 12 8 0,000 0,07649353 0,15219301 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,07649353 0,15206147 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,07649353 0,15193016 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,07649353 0,15179907 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,07649353 0,15166821 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,07649353 0,15153757 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,07649353 0,15140716 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,07649353 0,15127697 ! sterol catabolic process GO:0016127 9 8 0,000 0,07649353 0,15114701 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,07649353 0,15101727 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,07649353 0,15088775 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,07649353 0,15075846 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,07649353 0,15062938 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,07649353 0,15050053 ! prophase GO:0051324 11 8 0,000 0,07649353 0,1503719 ! S phase GO:0051320 8 8 0,000 0,07649353 0,15024349 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,07649353 0,15011529 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,07649353 0,14998732 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,07649353 0,14985956 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,07649353 0,14973202 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,07649353 0,14960469 ! hormone catabolic process GO:0042447 13 8 0,000 0,07649353 0,14947759 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,07649353 0,1493507 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,07649353 0,14922402 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,07649353 0,14909756 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,07649353 0,14897131 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,07649353 0,14884528 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,07649353 0,14871946 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,07649353 0,14859385 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,07649353 0,14846846 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,07649353 0,14834327 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,07649353 0,1482183 ! lamellipodium assembly GO:0030032 9 8 0,000 0,07649353 0,14809354 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,07649353 0,14796898 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,07649353 0,14784464 ! regulation of translation GO:0006417 151 100 2,000 0,0769472 0,14859662 ! homophilic cell adhesion GO:0007156 149 100 2,000 0,0769472 0,14847196 ! protein localization in organelle GO:0033365 161 100 2,000 0,0769472 0,1483475 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,07881581 0,15182276 ! endocrine system development GO:0035270 83 47 1,000 0,07881581 0,15169571 ! covalent chromatin modification GO:0016569 75 47 1,000 0,07881581 0,15156887 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,07881581 0,15144225 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,07881581 0,15131584 ! regulation of protein polymerization GO:0032271 71 47 1,000 0,07881581 0,15118963 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,08172563 0,15664079 ! gastrulation GO:0007369 73 48 1,000 0,08172563 0,15651037 ! heart morphogenesis GO:0003007 65 48 1,000 0,08172563 0,15638016 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,08172563 0,15625017 ! regulation of endocytosis GO:0030100 63 48 1,000 0,08172563 0,15612039 ! RNA elongation GO:0006354 62 49 1,000 0,08466821 0,16160738 ! germ cell development GO:0007281 68 49 1,000 0,08466821 0,16147337 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,08466821 0,16133959 ! maintenance of location GO:0051235 84 49 1,000 0,08466821 0,16120603 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,08563664 0,16291502 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,08563664 0,16278038 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,08563664 0,16264596 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,08563664 0,16251177 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,08563664 0,16237779 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,08563664 0,16224404 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,08563664 0,1621105 ! GTP metabolic process GO:0046039 9 9 0,000 0,08563664 0,16197719 ! elastic fiber assembly GO:0048251 13 9 0,000 0,08563664 0,16184409 ! social behavior GO:0035176 14 9 0,000 0,08563664 0,16171122 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,08563664 0,16157856 ! artery development GO:0060840 19 9 0,000 0,08563664 0,16144612 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,08563664 0,16131389 ! response to pain GO:0048265 16 9 0,000 0,08563664 0,16118188 ! protein complex disassembly GO:0043241 17 9 0,000 0,08563664 0,16105009 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,08563664 0,16091852 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,08563664 0,16078715 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,08563664 0,16065601 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,08563664 0,16052507 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,08563664 0,16039435 ! ventral spinal cord development GO:0021517 11 9 0,000 0,08563664 0,16026384 ! protein targeting to ER GO:0045047 19 9 0,000 0,08563664 0,16013355 ! T cell selection GO:0045058 18 9 0,000 0,08563664 0,16000346 ! endoderm development GO:0007492 12 9 0,000 0,08563664 0,15987359 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,08563664 0,15974393 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,08563664 0,15961448 ! arginine catabolic process GO:0006527 10 9 0,000 0,08563664 0,15948523 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,08563664 0,1593562 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,08563664 0,15922738 GO:0010833|telomere maintenance via telomere lengthening, ! V(D)J recombination GO:0033151 12 9 0,000 0,08563664 0,15909876 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,08563664 0,15897035 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,08563664 0,15884215 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,08563664 0,15871415 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,08563664 0,15858636 ! mannose metabolic process GO:0006013 9 9 0,000 0,08563664 0,15845878 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,08563664 0,1583314 ! receptor clustering GO:0043113 15 9 0,000 0,08563664 0,15820423 ! epithelial cell development GO:0002064 10 9 0,000 0,08563664 0,15807726 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,08563664 0,15795049 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,08563664 0,15782393 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,08563664 0,15769757 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,08563664 0,15757141 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,08563664 0,15744545 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,08563664 0,1573197 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,08563664 0,15719414 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,08563664 0,15706879 ! blastoderm segmentation GO:0007350 11 9 0,000 0,08563664 0,15694364 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,08563664 0,15681868 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,08563664 0,15669392 ! response to amine stimulus GO:0014075 13 9 0,000 0,08563664 0,15656937 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,08563664 0,15644501 ! erythrocyte development GO:0048821 11 9 0,000 0,08563664 0,15632084 ! renal water homeostasis GO:0003091 14 9 0,000 0,08563664 0,15619688 ! mRNA cleavage GO:0006379 13 9 0,000 0,08563664 0,15607311 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,08563664 0,15594954 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,08563664 0,15582616 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,08563664 0,15570297 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,08563664 0,15557999 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,08563664 0,15545719 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,08563664 0,15533459 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,08563664 0,15521219 ! acid secretion GO:0046717 14 9 0,000 0,08563664 0,15508997 ! musculoskeletal movement GO:0050881 11 9 0,000 0,08563664 0,15496795 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,08563664 0,15484612 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,08563664 0,15472448 ! purine base metabolic process GO:0006144 18 9 0,000 0,08563664 0,15460303 ! oocyte differentiation GO:0009994 12 9 0,000 0,08563664 0,15448177 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,08563664 0,15436071 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,08563664 0,15423983 ! spleen development GO:0048536 15 9 0,000 0,08563664 0,15411914 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,08563664 0,15399864 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,08563664 0,15387833 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,08563664 0,15375821 ! detection of calcium ion GO:0005513 13 9 0,000 0,08563664 0,15363827 ! blastocyst formation GO:0001825 12 9 0,000 0,08563664 0,15351852 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,08563664 0,15339896 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,08563664 0,15327958 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,08563664 0,15316039 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,08563664 0,15304139 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,08563664 0,15292256 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,08563664 0,15280393 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,08563664 0,15268548 ! prepulse inhibition GO:0060134 14 9 0,000 0,08563664 0,15256721 ! embryonic placenta development GO:0001892 12 9 0,000 0,08563664 0,15244912 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,08563664 0,15233122 ! insulin secretion GO:0030073 17 9 0,000 0,08563664 0,1522135 ! sequestering of metal ion GO:0051238 11 9 0,000 0,08563664 0,15209596 ! response to nicotine GO:0035094 16 9 0,000 0,08563664 0,1519786 ! establishment of cell polarity GO:0030010 12 9 0,000 0,08563664 0,15186142 ! nucleus localization GO:0051647 15 9 0,000 0,08563664 0,15174442 ! regulation of actin filament length GO:0030832 72 50 1,000 0,08764263 0,15517941 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,08764263 0,15506004 ! membrane fusion GO:0006944 80 50 1,000 0,08764263 0,15494086 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,09064798 0,16013084 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,09064798 0,16000795 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,09064798 0,15988524 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,09064798 0,15976272 ! transition metal ion transport GO:0000041 74 52 1,000 0,09368336 0,16498602 ! regulation of cellular component size GO:0032535 74 52 1,000 0,09368336 0,16485978 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,09368336 0,16473374 ! establishment of organelle localization GO:0051656 85 52 1,000 0,09368336 0,1646079 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,09468974 0,16624916 ! neuron fate specification GO:0048665 11 10 0,000 0,09468974 0,16612235 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,09468974 0,16599573 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,09468974 0,16586931 ! thyroid gland development GO:0030878 19 10 0,000 0,09468974 0,16574307 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,09468974 0,16561703 ! synapsis GO:0007129 13 10 0,000 0,09468974 0,16549118 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,09468974 0,16536553 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,09468974 0,16524006 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,09468974 0,16511478 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,09468974 0,1649897 ! sulfate transport GO:0008272 12 10 0,000 0,09468974 0,1648648 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,09468974 0,16474009 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,09468974 0,16461557 ! androgen metabolic process GO:0008209 13 10 0,000 0,09468974 0,16449124 ! phospholipid efflux GO:0033700 16 10 0,000 0,09468974 0,16436709 ! hippocampus development GO:0021766 19 10 0,000 0,09468974 0,16424314 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,09468974 0,16411937 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,09468974 0,16399578 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,09468974 0,16387238 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,09468974 0,16374917 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,09468974 0,16362615 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,09468974 0,1635033 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,09468974 0,16338064 ! melanocyte differentiation GO:0030318 15 10 0,000 0,09468974 0,16325817 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,09468974 0,16313588 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,09468974 0,16301377 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,09468974 0,16289185 ! B cell proliferation GO:0042100 14 10 0,000 0,09468974 0,1627701 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,09468974 0,16264854 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,09468974 0,16252716 ! lipid digestion GO:0044241 15 10 0,000 0,09468974 0,16240596 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,09468974 0,16228495 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,09468974 0,16216411 ! UV protection GO:0009650 14 10 0,000 0,09468974 0,16204345 ! entry into host cell GO:0030260 20 10 0,000 0,09468974 0,16192297 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,09468974 0,16180267 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,09468974 0,16168255 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,09468974 0,16156261 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,09468974 0,16144285 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,09468974 0,16132326 ! regulation of organ growth GO:0046620 11 10 0,000 0,09468974 0,16120385 ! response to dsRNA GO:0043331 18 10 0,000 0,09468974 0,16108461 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,09468974 0,16096556 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,09468974 0,16084668 ! embryonic axis specification GO:0000578 12 10 0,000 0,09468974 0,16072797 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,09468974 0,16060944 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,09468974 0,16049108 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,09468974 0,1603729 ! cranial nerve development GO:0021545 12 10 0,000 0,09468974 0,16025489 ! fucose catabolic process GO:0019317 16 10 0,000 0,09468974 0,16013706 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,09468974 0,1600194 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,09468974 0,15990191 ! protein sumoylation GO:0016925 12 10 0,000 0,09468974 0,15978459 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,09468974 0,15966745 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,09468974 0,15955048 ! zymogen activation GO:0031638 14 10 0,000 0,09468974 0,15943367 ! salivary gland development GO:0007431 22 10 0,000 0,09468974 0,15931704 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,09468974 0,15920058 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,09468974 0,15908429 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,09468974 0,15896817 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,09468974 0,15885222 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,09468974 0,15873644 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,09468974 0,15862083 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,09468974 0,15850539 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,09468974 0,15839011 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,09468974 0,158275 ! embryonic gut development GO:0048566 11 10 0,000 0,09468974 0,15816006 ! activation of innate immune response GO:0002218 10 10 0,000 0,09468974 0,15804528 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,09468974 0,15793067 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,09468974 0,15781623 ! developmental induction GO:0031128 13 10 0,000 0,09468974 0,15770195 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,09468974 0,15758784 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,09468974 0,1574739 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,09468974 0,15736011 ! kidney development GO:0001822 90 53 1,000 0,0967479 0,16066439 ! amino acid transport GO:0006865 84 54 1,000 0,09984073 0,16568086 ! regulation of protein complex assembly GO:0043254 81 54 1,000 0,09984073 0,16556141 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,09984073 0,16544213 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,09984073 0,16532302 ! DNA catabolic process GO:0006308 67 54 1,000 0,09984073 0,16520408 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,09984073 0,16508532 ! exocytosis GO:0006887 74 55 1,000 0,10296099 0,17012233 ! rRNA transcription GO:0009303 17 11 0,000 0,10365372 0,17114397 ! respiratory burst GO:0045730 14 11 0,000 0,10365372 0,1710212 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,10365372 0,17089861 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,10365372 0,17077619 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,10365372 0,17065394 ! RNA polyadenylation GO:0043631 19 11 0,000 0,10365372 0,17053187 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,10365372 0,17040998 ! mating GO:0007618 14 11 0,000 0,10365372 0,17028825 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,10365372 0,17016671 ! T cell proliferation GO:0042098 20 11 0,000 0,10365372 0,17004533 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,10365372 0,16992413 ! bone resorption GO:0045453 16 11 0,000 0,10365372 0,1698031 ! regulated secretory pathway GO:0045055 14 11 0,000 0,10365372 0,16968225 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,10365372 0,16956156 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,10365372 0,16944105 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,10365372 0,16932071 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,10365372 0,16920054 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,10365372 0,16908054 ! syncytium formation GO:0006949 15 11 0,000 0,10365372 0,16896071 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,10365372 0,16884104 ! mitotic spindle organization GO:0007052 15 11 0,000 0,10365372 0,16872155 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,10365372 0,16860223 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,10365372 0,16848308 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,10365372 0,16836409 ! adult heart development GO:0007512 11 11 0,000 0,10365372 0,16824528 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,10365372 0,16812663 ! temperature homeostasis GO:0001659 16 11 0,000 0,10365372 0,16800814 ! L-glutamate transport GO:0015813 16 11 0,000 0,10365372 0,16788983 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,10365372 0,16777168 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,10365372 0,1676537 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,10365372 0,16753588 ! stem cell development GO:0048864 29 11 0,000 0,10365372 0,16741823 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,10365372 0,16730074 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,10365372 0,16718342 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,10365372 0,16706626 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,10365372 0,16694927 ! vasoconstriction GO:0042310 15 11 0,000 0,10365372 0,16683244 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,10365372 0,16671577 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,10365372 0,16659927 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,10365372 0,16648293 ! ribosome assembly GO:0042255 13 11 0,000 0,10365372 0,16636675 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,10365372 0,16625074 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,10365372 0,16613488 ! chromatin silencing GO:0006342 19 11 0,000 0,10365372 0,16601919 ! nucleosome positioning GO:0016584 13 11 0,000 0,10365372 0,16590366 ! T cell homeostasis GO:0043029 20 11 0,000 0,10365372 0,16578829 ! regulation of isotype switching GO:0045191 19 11 0,000 0,10365372 0,16567308 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,10365372 0,16555802 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,10365372 0,16544313 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,10365372 0,1653284 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,10365372 0,16521383 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,10365372 0,16509941 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,10365372 0,16498516 ! male genitalia development GO:0030539 13 11 0,000 0,10365372 0,16487106 ! cholesterol efflux GO:0033344 19 11 0,000 0,10365372 0,16475712 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,10365372 0,16464334 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,10365372 0,16452971 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,10365372 0,16441624 ! germ cell migration GO:0008354 18 11 0,000 0,10365372 0,16430293 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,10365372 0,16418978 ! defense response to fungus GO:0050832 12 11 0,000 0,10365372 0,16407678 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,10365372 0,16396393 ! lysogeny GO:0030069 18 11 0,000 0,10365372 0,16385124 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,10365372 0,16373871 ! acrosome reaction GO:0007340 13 11 0,000 0,10365372 0,16362632 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,10365372 0,1635141 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,10610785 0,16727077 ! carbohydrate transport GO:0008643 74 57 1,000 0,10928049 0,17215419 ! camera-type eye development GO:0043010 88 57 1,000 0,10928049 0,17203636 ! secondary metabolic process GO:0019748 84 57 1,000 0,10928049 0,17191869 ! viral reproductive process GO:0022415 87 58 1,000 0,11247809 0,17682816 ! lactation GO:0007595 20 12 0,000 0,11252945 0,17678807 ! reproductive cellular process GO:0048610 14 12 0,000 0,11252945 0,1766674 ! tRNA modification GO:0006400 14 12 0,000 0,11252945 0,17654689 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,11252945 0,17642654 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,11252945 0,17630636 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,11252945 0,17618634 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,11252945 0,17606649 ! non-recombinational repair GO:0000726 19 12 0,000 0,11252945 0,1759468 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,11252945 0,17582727 ! peroxisomal transport GO:0043574 21 12 0,000 0,11252945 0,1757079 ! cartilage condensation GO:0001502 18 12 0,000 0,11252945 0,1755887 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,11252945 0,17546965 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,11252945 0,17535077 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,11252945 0,17523205 ! heart looping GO:0001947 15 12 0,000 0,11252945 0,17511349 ! palate development GO:0060021 15 12 0,000 0,11252945 0,17499509 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,11252945 0,17487685 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,11252945 0,17475877 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,11252945 0,17464085 ! arginine metabolic process GO:0006525 13 12 0,000 0,11252945 0,17452309 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,11252945 0,17440548 ! methionine metabolic process GO:0006555 13 12 0,000 0,11252945 0,17428804 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,11252945 0,17417075 ! Golgi organization GO:0007030 18 12 0,000 0,11252945 0,17405362 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,11252945 0,17393665 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,11252945 0,17381984 ! monoamine transport GO:0015844 13 12 0,000 0,11252945 0,17370318 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,11252945 0,17358668 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,11252945 0,17347033 ! L-amino acid transport GO:0015807 20 12 0,000 0,11252945 0,17335414 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,11252945 0,17323811 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,11252945 0,17312223 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,11252945 0,17300651 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,11252945 0,17289094 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,11252945 0,17277553 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,11252945 0,17266027 ! cerebellum development GO:0021549 13 12 0,000 0,11252945 0,17254516 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,11252945 0,17243021 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,11252945 0,1723154 ! histone methylation GO:0016571 15 12 0,000 0,11252945 0,17220076 ! autonomic nervous system development GO:0048483 23 12 0,000 0,11252945 0,17208626 ! gland morphogenesis GO:0022612 23 12 0,000 0,11252945 0,17197192 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,11252945 0,17185773 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,11252945 0,17174369 ! regulation of epidermis development GO:0045682 17 12 0,000 0,11252945 0,1716298 ! intestinal absorption GO:0050892 19 12 0,000 0,11252945 0,17151606 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,11252945 0,17140248 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,11252945 0,17128904 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,11252945 0,17117575 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,11252945 0,17106262 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,11252945 0,17094963 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,11252945 0,17083679 ! response to cold GO:0009409 14 12 0,000 0,11252945 0,1707241 ! actin filament organization GO:0007015 95 59 1,000 0,11569985 0,17541836 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 1,000 0,118945 0,18021969 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,118945 0,18010105 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,118945 0,17998256 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,1213178 0,18345229 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,1213178 0,18333176 ! cGMP metabolic process GO:0046068 16 13 0,000 0,1213178 0,18321138 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,1213178 0,18309116 ! water transport GO:0006833 17 13 0,000 0,1213178 0,1829711 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,1213178 0,1828512 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,1213178 0,18273146 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,1213178 0,18261187 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,1213178 0,18249244 ! organelle fusion GO:0048284 28 13 0,000 0,1213178 0,18237316 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,1213178 0,18225404 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,1213178 0,18213507 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,1213178 0,18201626 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,1213178 0,18189761 ! response to hexose stimulus GO:0009746 19 13 0,000 0,1213178 0,18177911 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,1213178 0,18166076 ! glutamate metabolic process GO:0006536 18 13 0,000 0,1213178 0,18154257 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,1213178 0,18142453 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,1213178 0,18130665 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,1213178 0,18118892 ! NAD metabolic process GO:0019674 21 13 0,000 0,1213178 0,18107134 ! exocrine system development GO:0035272 27 13 0,000 0,1213178 0,18095391 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,1213178 0,18083664 ! bone mineralization GO:0030282 15 13 0,000 0,1213178 0,18071952 ! regulation of exocytosis GO:0017157 17 13 0,000 0,1213178 0,18060255 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,1213178 0,18048573 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,1213178 0,18036906 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,1213178 0,18025254 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,1213178 0,18013617 ! genitalia development GO:0048806 15 13 0,000 0,1213178 0,18001996 ! cellular pigmentation GO:0033059 24 13 0,000 0,1213178 0,17990389 ! tissue regeneration GO:0042246 21 13 0,000 0,1213178 0,17978797 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,1213178 0,1796722 ! cofactor transport GO:0051181 19 13 0,000 0,1213178 0,17955659 ! NADP metabolic process GO:0006739 18 13 0,000 0,1213178 0,17944111 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,1213178 0,17932579 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,1213178 0,17921062 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,1213178 0,17909559 ! gas transport GO:0015669 18 13 0,000 0,1213178 0,17898071 ! heme biosynthetic process GO:0006783 20 13 0,000 0,1213178 0,17886598 ! regulation of axon extension GO:0030516 23 13 0,000 0,1213178 0,1787514 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,1213178 0,17863696 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,1213178 0,17852267 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,1213178 0,17840853 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,1213178 0,17829453 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,1213178 0,17818067 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,1213178 0,17806696 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,12221276 0,17926616 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,12221276 0,17915191 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,12221276 0,1790378 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,12550237 0,18373994 ! organelle localization GO:0051640 96 62 1,000 0,12550237 0,18362306 ! viral reproduction GO:0016032 92 63 1,000 0,12881309 0,18834717 ! regulation of lipase activity GO:0060191 109 63 1,000 0,12881309 0,18822751 ! superoxide anion generation GO:0042554 18 14 0,000 0,13001961 0,18986991 ! neuron maturation GO:0042551 21 14 0,000 0,13001961 0,18974944 ! regulation of S phase GO:0033261 18 14 0,000 0,13001961 0,18962911 ! myotube differentiation GO:0014902 21 14 0,000 0,13001961 0,18950894 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,13001961 0,18938892 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,13001961 0,18926906 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,13001961 0,18914934 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,13001961 0,18902978 ! gene silencing by RNA GO:0031047 20 14 0,000 0,13001961 0,18891037 ! response to cAMP GO:0051591 19 14 0,000 0,13001961 0,1887911 ! startle response GO:0001964 21 14 0,000 0,13001961 0,18867199 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,13001961 0,18855303 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,13001961 0,18843422 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,13001961 0,18831556 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,13001961 0,18819705 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,13001961 0,18807869 ! glycine metabolic process GO:0006544 22 14 0,000 0,13001961 0,18796047 ! lysosomal transport GO:0007041 20 14 0,000 0,13001961 0,18784241 ! regulation of heart rate GO:0002027 23 14 0,000 0,13001961 0,18772449 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,13001961 0,18760672 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,13001961 0,1874891 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,13001961 0,18737162 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,13001961 0,1872543 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,13001961 0,18713712 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,13001961 0,18702008 ! axon cargo transport GO:0008088 27 14 0,000 0,13001961 0,18690319 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,13001961 0,18678645 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,13001961 0,18666986 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,13001961 0,18655341 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,13001961 0,1864371 ! mRNA splice site selection GO:0006376 26 14 0,000 0,13001961 0,18632094 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,13001961 0,18620493 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,13001961 0,18608905 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,13001961 0,18597333 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,13001961 0,18585774 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,13001961 0,1857423 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,13001961 0,18562701 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,13001961 0,18551185 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,13001961 0,18539684 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,13001961 0,18528198 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,13001961 0,18516725 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,13001961 0,18505267 ! cell killing GO:0001906 20 14 0,000 0,13001961 0,18493823 ! cilium assembly GO:0042384 20 14 0,000 0,13001961 0,18482392 ! peptide hormone secretion GO:0030072 23 14 0,000 0,13001961 0,18470977 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,13214418 0,1876121 ! adaptive immune response GO:0002250 94 64 1,000 0,13214418 0,18749636 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,13549492 0,19213213 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,13549492 0,19201375 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,13549492 0,19189552 ! positive regulation of cell size GO:0045793 20 15 0,000 0,13863575 0,1962229 ! metencephalon development GO:0022037 19 15 0,000 0,13863575 0,19610222 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,13863575 0,19598169 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,13863575 0,19586131 ! skin development GO:0043588 25 15 0,000 0,13863575 0,19574108 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,13863575 0,19562099 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,13863575 0,19550105 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,13863575 0,19538126 ! bile acid metabolic process GO:0008206 22 15 0,000 0,13863575 0,19526161 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,13863575 0,19514211 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,13863575 0,19502276 ! adult walking behavior GO:0007628 25 15 0,000 0,13863575 0,19490355 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,13863575 0,19478449 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,13863575 0,19466558 ! myoblast differentiation GO:0045445 27 15 0,000 0,13863575 0,19454681 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,13863575 0,19442818 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,13863575 0,1943097 ! response to osmotic stress GO:0006970 22 15 0,000 0,13863575 0,19419136 ! vesicle coating GO:0006901 25 15 0,000 0,13863575 0,19407317 ! DNA integration GO:0015074 22 15 0,000 0,13863575 0,19395512 ! peptide secretion GO:0002790 27 15 0,000 0,13863575 0,19383721 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,13863575 0,19371945 ! regulation of vasodilation GO:0042312 24 15 0,000 0,13863575 0,19360183 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,13863575 0,19348435 ! neuron recognition GO:0008038 22 15 0,000 0,13863575 0,19336702 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,13863575 0,19324983 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,13863575 0,19313278 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,13863575 0,19301587 ! biomineral formation GO:0031214 18 15 0,000 0,13863575 0,1928991 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,13863575 0,19278248 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,13863575 0,19266599 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,13863575 0,19254965 ! dopamine metabolic process GO:0042417 30 15 0,000 0,13863575 0,19243344 ! organic cation transport GO:0015695 19 15 0,000 0,13863575 0,19231738 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,13863575 0,19220146 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,13863575 0,19208567 ! defense response to virus GO:0051607 27 15 0,000 0,13863575 0,19197003 ! peptide hormone processing GO:0016486 19 15 0,000 0,13863575 0,19185452 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,13886461 0,19205568 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,14225254 0,19662311 ! acute inflammatory response GO:0002526 92 68 1,000 0,14565804 0,2012093 ! regulation of Ras GTPase activity GO:0032318 110 68 1,000 0,14565804 0,20108853 ! inorganic anion transport GO:0015698 93 68 1,000 0,14565804 0,2009679 ! protein secretion GO:0009306 27 16 0,000 0,14716703 0,20292816 ! hormone secretion GO:0046879 25 16 0,000 0,14716703 0,20280658 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,14716703 0,20268514 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,14716703 0,20256384 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,14716703 0,20244269 ! patterning of blood vessels GO:0001569 24 16 0,000 0,14716703 0,20232169 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,14716703 0,20220082 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,14716703 0,20208011 ! protein polyubiquitination GO:0000209 26 16 0,000 0,14716703 0,20195953 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,14716703 0,2018391 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,14716703 0,20171882 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,14716703 0,20159868 ! regulation of protein binding GO:0043393 27 16 0,000 0,14716703 0,20147868 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,14716703 0,20135882 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,14716703 0,20123911 ! protein export from nucleus GO:0006611 24 16 0,000 0,14716703 0,20111954 ! negative regulation of immune response GO:0050777 28 16 0,000 0,14716703 0,20100011 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,14716703 0,20088082 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,14716703 0,20076167 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,14716703 0,20064267 ! oogenesis GO:0048477 23 16 0,000 0,14716703 0,2005238 ! neural crest cell migration GO:0001755 24 16 0,000 0,14716703 0,20040508 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,14716703 0,2002865 GO:0006626|protein targeting to mitochondrion, ! steroid catabolic process GO:0006706 22 16 0,000 0,14716703 0,20016805 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,14716703 0,20004975 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,14716703 0,19993159 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,14716703 0,19981356 ! sperm-egg recognition GO:0035036 16 16 0,000 0,14716703 0,19969568 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,14716703 0,19957794 ! nerve development GO:0021675 18 16 0,000 0,14716703 0,19946033 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,14716703 0,19934286 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,14716703 0,19922553 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,14908042 0,20169704 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 1,000 0,15251904 0,20622797 ! amine transport GO:0015837 101 70 1,000 0,15251904 0,2061068 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,15251904 0,20598578 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,15561431 0,21004279 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,15561431 0,2099196 ! negative regulation of defense response GO:0031348 19 17 0,000 0,15561431 0,20979655 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,15561431 0,20967364 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,15561431 0,20955088 ! glycerol metabolic process GO:0006071 20 17 0,000 0,15561431 0,20942827 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,15561431 0,2093058 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,15561431 0,20918347 ! signal complex assembly GO:0007172 29 17 0,000 0,15561431 0,20906128 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,15561431 0,20893924 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,15561431 0,20881733 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,15561431 0,20869558 ! keratinization GO:0031424 17 17 0,000 0,15561431 0,20857396 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,15561431 0,20845248 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,15561431 0,20833115 ! retinoid metabolic process GO:0001523 22 17 0,000 0,15561431 0,20820995 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,15561431 0,2080889 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,15561431 0,20796799 ! vacuolar transport GO:0007034 24 17 0,000 0,15561431 0,20784722 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,15561431 0,20772659 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,15561431 0,2076061 ! membrane budding GO:0006900 29 17 0,000 0,15561431 0,20748575 ! heme metabolic process GO:0042168 27 17 0,000 0,15561431 0,20736553 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,15561431 0,20724546 ! body fluid secretion GO:0007589 27 17 0,000 0,15561431 0,20712553 ! stem cell differentiation GO:0048863 36 17 0,000 0,15561431 0,20700573 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,15561431 0,20688608 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,15561431 0,20676656 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,15561431 0,20664718 ! sensory perception of pain GO:0019233 23 17 0,000 0,15561431 0,20652793 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,15561431 0,20640883 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,15561431 0,20628986 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,15561431 0,20617103 ! synaptogenesis GO:0007416 24 17 0,000 0,15561431 0,20605234 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,15561431 0,20593378 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,15561431 0,20581536 ! cell-cell junction organization GO:0045216 25 17 0,000 0,15561431 0,20569708 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,15561431 0,20557893 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,15561431 0,20546091 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,15561431 0,20534304 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,15561431 0,20522529 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,15944234 0,21015323 ! tube morphogenesis GO:0035239 118 73 1,000 0,16292577 0,21462158 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,16292577 0,21449873 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,16397839 0,21576104 ! positive regulation of translation GO:0045727 28 18 0,000 0,16397839 0,21563768 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,16397839 0,21551446 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,16397839 0,21539138 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,16397839 0,21526844 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,16397839 0,21514564 ! cAMP metabolic process GO:0046058 33 18 0,000 0,16397839 0,21502298 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,16397839 0,21490046 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,16397839 0,21477808 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,16397839 0,21465584 ! axis specification GO:0009798 26 18 0,000 0,16397839 0,21453373 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,16397839 0,21441177 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,16397839 0,21428995 ! pancreas development GO:0031016 26 18 0,000 0,16397839 0,21416826 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,16397839 0,21404671 ! glutamine metabolic process GO:0006541 23 18 0,000 0,16397839 0,2139253 ! central nervous system neuron development GO:0021954 30 18 0,000 0,16397839 0,21380403 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,16397839 0,21368289 ! fucose metabolic process GO:0006004 26 18 0,000 0,16397839 0,21356189 ! response to fungus GO:0009620 19 18 0,000 0,16397839 0,21344103 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,16397839 0,21332031 ! heart process GO:0003015 27 18 0,000 0,16397839 0,21319972 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,16397839 0,21307927 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,16397839 0,21295895 ! visual learning GO:0008542 35 18 0,000 0,16397839 0,21283877 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,16397839 0,21271873 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,16397839 0,21259882 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,16397839 0,21247904 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,16397839 0,21235941 ! vitamin transport GO:0051180 24 18 0,000 0,16397839 0,2122399 ! hormone transport GO:0009914 27 18 0,000 0,16397839 0,21212053 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,16397839 0,2120013 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,16397839 0,21188219 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,16397839 0,21176323 ! cell-cell recognition GO:0009988 20 18 0,000 0,16397839 0,21164439 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,16397839 0,21152569 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,16397839 0,21140712 ! gut development GO:0048565 26 18 0,000 0,16397839 0,21128869 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,16642289 0,2143184 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,1722601 0,22171138 ! positive regulation of ossification GO:0045778 30 19 0,000 0,1722601 0,22158738 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,1722601 0,22146352 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,1722601 0,22133979 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,1722601 0,22121621 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,1722601 0,22109276 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,1722601 0,22096945 ! regeneration GO:0031099 32 19 0,000 0,1722601 0,22084628 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,1722601 0,22072325 ! response to alkaloid GO:0043279 32 19 0,000 0,1722601 0,22060035 ! sensory perception of taste GO:0050909 23 19 0,000 0,1722601 0,22047759 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,1722601 0,22035497 ! smooth muscle contraction GO:0006939 36 19 0,000 0,1722601 0,22023248 ! peroxisome organization GO:0007031 29 19 0,000 0,1722601 0,22011013 ! digestive system process GO:0022600 30 19 0,000 0,1722601 0,21998791 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,1722601 0,21986583 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,1722601 0,21974389 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,1722601 0,21962208 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,1722601 0,21950041 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,1722601 0,21937887 ! cytolysis GO:0019835 20 19 0,000 0,1722601 0,21925746 ! renal system process GO:0003014 35 19 0,000 0,1722601 0,21913619 ! vasodilation GO:0042311 33 19 0,000 0,1722601 0,21901505 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,1722601 0,21889405 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,1722601 0,21877318 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,1722601 0,21865245 ! sarcomere organization GO:0045214 23 19 0,000 0,1722601 0,21853184 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,1722601 0,21841137 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,1722601 0,21829104 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,1722601 0,21817083 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,1722601 0,21805076 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,1722601 0,21793082 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,1722601 0,21781101 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,1722601 0,21769134 ! protein stabilization GO:0050821 26 19 0,000 0,1722601 0,21757179 ! amine biosynthetic process GO:0009309 97 76 1,000 0,17345578 0,21896175 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,17699037 0,22330107 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,18046024 0,22755403 ! iron ion transport GO:0006826 37 20 0,000 0,18046024 0,22742934 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,18046024 0,22730479 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,18046024 0,22718038 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,18046024 0,2270561 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,18046024 0,22693196 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,18046024 0,22680795 ! spinal cord development GO:0021510 31 20 0,000 0,18046024 0,22668408 ! response to ethanol GO:0045471 37 20 0,000 0,18046024 0,22656034 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,18046024 0,22643674 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,18046024 0,22631328 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,18046024 0,22618994 ! chromosome condensation GO:0030261 31 20 0,000 0,18046024 0,22606675 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,18046024 0,22594368 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,18046024 0,22582075 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,18046024 0,22569796 ! DNA modification GO:0006304 28 20 0,000 0,18046024 0,2255753 ! collagen fibril organization GO:0030199 45 20 0,000 0,18046024 0,22545277 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,18046024 0,22533037 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,18046024 0,22520811 ! collagen catabolic process GO:0030574 25 20 0,000 0,18046024 0,22508598 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,18046024 0,22496398 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,18046024 0,22484212 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,18046024 0,22472038 ! alditol metabolic process GO:0019400 24 20 0,000 0,18046024 0,22459878 ! actin filament-based movement GO:0030048 34 20 0,000 0,18046024 0,22447731 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,18765983 0,23330682 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 1,000 0,18765983 0,23318078 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,1885796 0,23419713 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,1885796 0,23407075 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,1885796 0,23394449 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,1885796 0,23381838 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,1885796 0,2336924 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,1885796 0,23356655 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,1885796 0,23344085 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,1885796 0,23331527 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,1885796 0,23318983 ! vesicle docking GO:0048278 27 21 0,000 0,1885796 0,23306453 ! phototransduction GO:0007602 25 21 0,000 0,1885796 0,23293936 ! visual behavior GO:0007632 39 21 0,000 0,1885796 0,23281433 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,1885796 0,23268943 ! ovarian follicle development GO:0001541 30 21 0,000 0,1885796 0,23256466 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,1885796 0,23244003 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,1885796 0,23231553 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,1885796 0,23219116 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,1885796 0,23206693 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,1885796 0,23194283 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,1885796 0,23181886 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,1885796 0,23169503 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,1885796 0,23157132 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,1885796 0,23144775 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,1885796 0,23132432 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,1885796 0,23120101 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,1885796 0,23107783 ! fatty acid transport GO:0015908 30 21 0,000 0,1885796 0,23095479 ! immunoglobulin production GO:0002377 33 21 0,000 0,1885796 0,23083187 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,1885796 0,23070909 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,1885796 0,23058644 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,1885796 0,23046392 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,1885796 0,23034152 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,1885796 0,23021926 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,1885796 0,23009713 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,1885796 0,22997513 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,1885796 0,22985325 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,1885796 0,22973151 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,1885796 0,22960989 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,1885796 0,22948841 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,1885796 0,22936705 ! regulation of neurological system process GO:0031644 122 81 1,000 0,19123636 0,2324755 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,19123636 0,23235269 GO:0002696|positive regulation of leukocyte activation, ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,19661899 0,23876646 ! viral genome replication GO:0019079 29 22 0,000 0,19661899 0,23864046 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,19661899 0,2385146 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,19661899 0,23838887 ! molting cycle process GO:0022404 40 22 0,000 0,19661899 0,23826327 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 0,000 0,19661899 0,2381378 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,19661899 0,23801246 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,19661899 0,23788726 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,19661899 0,23776219 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,19661899 0,23763725 ! lysosome organization GO:0007040 37 22 0,000 0,19661899 0,23751244 ! ureteric bud development GO:0001657 32 22 0,000 0,19661899 0,23738776 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,19661899 0,23726321 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,19661899 0,23713879 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,19661899 0,23701451 ! membrane depolarization GO:0051899 35 22 0,000 0,19661899 0,23689035 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,19661899 0,23676632 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,19661899 0,23664243 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,19661899 0,23651866 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,19661899 0,23639502 ! blastocyst development GO:0001824 37 22 0,000 0,19661899 0,23627151 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,19661899 0,23614814 ! neuron fate commitment GO:0048663 32 23 0,000 0,20457918 0,24558044 ! embryonic pattern specification GO:0009880 31 23 0,000 0,20457918 0,24545233 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,20457918 0,24532436 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,20457918 0,24519652 ! vesicle targeting GO:0006903 32 23 0,000 0,20457918 0,24506881 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,20457918 0,24494124 ! osteoblast differentiation GO:0001649 40 23 0,000 0,20457918 0,2448138 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,20457918 0,24468649 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,20457918 0,24455931 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,20457918 0,24443227 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,20457918 0,24430536 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,20457918 0,24417858 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,20457918 0,24405193 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,20457918 0,24392541 ! cell fate determination GO:0001709 45 23 0,000 0,20457918 0,24379902 ! pentose metabolic process GO:0019321 31 23 0,000 0,20457918 0,24367277 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,20457918 0,24354664 ! spermatid development GO:0007286 33 23 0,000 0,20457918 0,24342065 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,20457918 0,24329479 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,20457918 0,24316905 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,20457918 0,24304345 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,20457918 0,24291797 ! telomere organization GO:0032200 32 23 0,000 0,20457918 0,24279263 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,20457918 0,24266741 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,20457918 0,24254233 ! regulation of amine transport GO:0051952 38 23 0,000 0,20457918 0,24241737 ! liver development GO:0001889 40 23 0,000 0,20457918 0,24229254 ! transcription initiation GO:0006352 118 85 1,000 0,20562848 0,24340993 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,20562848 0,24328472 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,21246095 0,25123917 ! initiation of viral infection GO:0019059 42 24 0,000 0,21246095 0,25111006 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,21246095 0,25098109 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,21246095 0,25085225 ! superoxide metabolic process GO:0006801 32 24 0,000 0,21246095 0,25072354 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,21246095 0,25059497 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,21246095 0,25046652 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,21246095 0,25033821 ! sperm motility GO:0030317 27 24 0,000 0,21246095 0,25021003 ! vacuole organization GO:0007033 39 24 0,000 0,21246095 0,25008198 ! receptor metabolic process GO:0043112 37 24 0,000 0,21246095 0,24995406 ! neural crest cell development GO:0014032 39 24 0,000 0,21246095 0,24982627 GO:0014033|neural crest cell differentiation, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,21246095 0,24969861 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,21246095 0,24957109 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,21246095 0,24944369 ! glutathione metabolic process GO:0006749 29 24 0,000 0,21246095 0,24931642 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,21246095 0,24918928 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,21246095 0,24906228 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,21246095 0,2489354 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,21649862 0,25353708 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,22026507 0,25781662 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,22026507 0,25768548 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,22026507 0,25755447 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,22026507 0,2574236 ! peptide transport GO:0015833 43 25 0,000 0,22026507 0,25729287 ! iron ion homeostasis GO:0055072 39 25 0,000 0,22026507 0,25716226 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,22026507 0,25703179 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,22026507 0,25690145 ! phospholipid transport GO:0015914 35 25 0,000 0,22026507 0,25677124 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,22026507 0,25664116 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,22026507 0,25651122 ! detection of light stimulus GO:0009583 30 25 0,000 0,22026507 0,2563814 ! leukocyte proliferation GO:0070661 39 25 0,000 0,22026507 0,25625172 GO:0032943|mononuclear cell proliferation, ! response to virus GO:0009615 122 91 1,000 0,22741946 0,26444123 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,22799229 0,26497335 ! translational initiation GO:0006413 43 26 0,000 0,22799229 0,26483953 ! circadian rhythm GO:0007623 42 26 0,000 0,22799229 0,26470584 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,22799229 0,26457228 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,22799229 0,26443886 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,22799229 0,26430558 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,22799229 0,26417243 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,22799229 0,26403941 ! regulation of coagulation GO:0050818 39 26 0,000 0,22799229 0,26390653 ! DNA recombination GO:0006310 146 92 1,000 0,23106886 0,26733319 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,23564337 0,27248857 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,23564337 0,27235164 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,23564337 0,27221485 ! membrane docking GO:0022406 39 27 0,000 0,23564337 0,27207819 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,23564337 0,27194168 ! catechol metabolic process GO:0009712 43 27 0,000 0,23564337 0,2718053 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,23564337 0,27166905 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,23564337 0,27153295 ! myofibril assembly GO:0030239 36 27 0,000 0,23564337 0,27139698 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,23564337 0,27126114 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,23564337 0,27112544 ! natural killer cell activation GO:0030101 35 27 0,000 0,23564337 0,27098988 ! lipid oxidation GO:0034440 38 27 0,000 0,23564337 0,27085445 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,23564337 0,27071916 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,23564337 0,270584 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,23564337 0,27044898 ! gene silencing GO:0016458 41 27 0,000 0,23564337 0,27031409 ! carboxylic acid transport GO:0046942 147 95 1,000 0,24203829 0,2775115 GO:0015849|organic acid transport, ! mRNA export from nucleus GO:0006406 39 28 0,000 0,24321907 0,27872638 ! phenol metabolic process GO:0018958 44 28 0,000 0,24321907 0,27858758 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,24321907 0,27844891 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,24321907 0,27831037 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,24321907 0,27817198 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,24321907 0,27803372 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,24321907 0,2778956 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,24321907 0,27775762 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,24321907 0,27761978 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,24321907 0,27748207 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,24321907 0,2773445 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,24321907 0,27720706 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,24321907 0,27706976 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,24321907 0,2769326 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,24321907 0,27679557 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,24321907 0,27665868 ! BMP signaling pathway GO:0030509 40 28 0,000 0,24321907 0,27652192 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,24321907 0,2763853 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,24321907 0,27624882 ! placenta development GO:0001890 37 28 0,000 0,24321907 0,27611246 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,2507201 0,28448754 ! regulation of innate immune response GO:0045088 38 29 0,000 0,2507201 0,28434726 ! ovulation cycle process GO:0022602 41 29 0,000 0,2507201 0,28420711 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,2507201 0,28406711 ! protein targeting to membrane GO:0006612 53 29 0,000 0,2507201 0,28392725 ! mismatch repair GO:0006298 34 29 0,000 0,2507201 0,28378752 ! muscle cell development GO:0055001 38 29 0,000 0,2507201 0,28364793 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,2507201 0,28350847 ! eye morphogenesis GO:0048592 51 29 0,000 0,2507201 0,28336916 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,2507201 0,28322998 ! tissue homeostasis GO:0001894 42 29 0,000 0,2507201 0,28309094 GO:0048871|multicellular organismal homeostasis, ! extracellular structure organization GO:0043062 156 99 1,000 0,25669819 0,28969865 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,25814722 0,29119107 ! collagen metabolic process GO:0032963 40 30 0,000 0,25814722 0,29104833 ! organic anion transport GO:0015711 51 30 0,000 0,25814722 0,29090573 ! cholesterol transport GO:0030301 46 30 0,000 0,25814722 0,29076327 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,25814722 0,29062095 ! spliceosome assembly GO:0000245 49 30 0,000 0,25814722 0,29047877 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,25814722 0,29033672 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,25814722 0,29019482 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,25814722 0,29005305 ! ceramide metabolic process GO:0006672 43 30 0,000 0,25814722 0,28991143 ! ovulation cycle GO:0042698 43 30 0,000 0,25814722 0,28976994 ! hindbrain development GO:0030902 45 30 0,000 0,25814722 0,28962858 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,25814722 0,28948737 ! adult locomotory behavior GO:0008344 47 30 0,000 0,25814722 0,2893463 ! response to heat GO:0009408 41 30 0,000 0,25814722 0,28920536 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,25814722 0,28906456 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,25814722 0,28892389 ! negative regulation of secretion GO:0051048 49 31 0,000 0,26550113 0,29701002 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,26550113 0,29686563 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,26550113 0,29672138 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,26550113 0,29657727 ! odontogenesis GO:0042476 50 31 0,000 0,26550113 0,2964333 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,26550113 0,29628947 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,26550113 0,29614578 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,26550113 0,29600223 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,26550113 0,29585882 ! RNA modification GO:0009451 40 31 0,000 0,26550113 0,29571555 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,27278257 0,30367856 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,27278257 0,30353164 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,27278257 0,30338487 ! cytokine production GO:0001816 44 32 0,000 0,27278257 0,30323823 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,27278257 0,30309174 ! vesicle localization GO:0051648 47 32 0,000 0,27278257 0,30294539 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,27999223 0,31080218 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,27999223 0,31065226 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,27999223 0,31050247 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,27999223 0,31035283 ! ear morphogenesis GO:0042471 42 33 0,000 0,27999223 0,31020334 ! actomyosin structure organization GO:0031032 43 33 0,000 0,27999223 0,31005398 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,27999223 0,30990478 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,27999223 0,30975571 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,27999223 0,30960679 ! female gonad development GO:0008585 49 33 0,000 0,27999223 0,30945801 ! positive regulation of cell development GO:0010720 54 33 0,000 0,27999223 0,30930938 ! lipid homeostasis GO:0055088 55 33 0,000 0,27999223 0,30916089 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,27999223 0,30901254 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,27999223 0,30886433 ! mRNA catabolic process GO:0006402 48 34 0,000 0,28713082 0,3165872 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,28713082 0,3164355 ! feeding behavior GO:0007631 45 34 0,000 0,28713082 0,31628395 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,28713082 0,31613255 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,28713082 0,31598129 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,28713082 0,31583017 ! female gamete generation GO:0007292 43 34 0,000 0,28713082 0,3156792 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,28713082 0,31552838 ! aerobic respiration GO:0009060 47 34 0,000 0,28713082 0,3153777 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,28713082 0,31522716 ! embryonic organ development GO:0048568 45 34 0,000 0,28713082 0,31507676 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,29419905 0,32267897 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,29419905 0,32252517 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,29419905 0,32237151 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,29419905 0,322218 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,29419905 0,32206464 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,29419905 0,32191142 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,29419905 0,32175835 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,29419905 0,32160542 ! pigment metabolic process GO:0042440 61 35 0,000 0,29419905 0,32145264 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,30119759 0,32894324 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,30119759 0,32878712 ! organic ether metabolic process GO:0018904 46 36 0,000 0,30119759 0,32863115 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,30119759 0,32847532 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,30119759 0,32831965 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,30119759 0,32816412 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,30119759 0,32800874 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,30812713 0,33539631 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,30812713 0,33523766 ! learning GO:0007612 67 37 0,000 0,30812713 0,33507915 ! ion transmembrane transport GO:0034220 56 37 0,000 0,30812713 0,3349208 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,30812713 0,33476259 ! regulation of protein secretion GO:0050708 51 37 0,000 0,30812713 0,33460454 ! amino acid activation GO:0043038 52 37 0,000 0,30812713 0,33444663 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,30812713 0,33428887 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,31498835 0,34157153 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,31498835 0,34141056 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,31498835 0,34124975 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,31498835 0,34108908 ! phagocytosis GO:0006909 60 38 0,000 0,31498835 0,34092857 ! maintenance of location in cell GO:0051651 69 38 0,000 0,31498835 0,34076821 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,32178192 0,34795413 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,32178192 0,34779061 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,32178192 0,34762725 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,32178192 0,34746405 ! chromatin remodeling GO:0006338 68 39 0,000 0,32178192 0,347301 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,32178192 0,3471381 ! developmental growth GO:0048589 62 39 0,000 0,32178192 0,34697535 ! response to calcium ion GO:0051592 58 40 0,000 0,3285085 0,35406259 ! regulation of tube size GO:0035150 60 40 0,000 0,3285085 0,35389675 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,3285085 0,35373107 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,3285085 0,35356554 ! peptide metabolic process GO:0006518 56 40 0,000 0,3285085 0,35340017 ! inner ear development GO:0048839 57 40 0,000 0,3285085 0,35323495 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,3285085 0,35306989 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,3285085 0,35290498 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,3285085 0,35274022 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,33516875 0,35972381 ! endosome transport GO:0016197 71 41 0,000 0,33516875 0,35955603 ! striated muscle contraction GO:0006941 62 41 0,000 0,33516875 0,3593884 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,33516875 0,35922093 ! biopolymer methylation GO:0043414 62 41 0,000 0,33516875 0,35905362 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,33516875 0,35888646 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,34176332 0,3657774 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,34176332 0,36560727 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,34176332 0,3654373 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,34176332 0,36526748 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,34176332 0,36509783 ! excretion GO:0007588 63 42 0,000 0,34176332 0,36492833 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,34176332 0,36475899 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,34176332 0,36458981 ! neuromuscular process GO:0050905 79 43 0,000 0,34829284 0,37138319 ! tRNA processing GO:0008033 49 43 0,000 0,34829284 0,37121109 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,34829284 0,37103916 ! vesicle organization GO:0016050 79 43 0,000 0,34829284 0,37086738 ! methylation GO:0032259 64 43 0,000 0,34829284 0,37069576 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,35475797 0,37740209 ! regulation of ion transport GO:0043269 57 44 0,000 0,35475797 0,37722761 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,35475797 0,37705329 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,35475797 0,37687913 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,35475797 0,37670514 ! RNA catabolic process GO:0006401 64 45 0,000 0,36115933 0,38332554 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,36115933 0,38314873 ! cell recognition GO:0008037 58 45 0,000 0,36115933 0,38297208 ! cell maturation GO:0048469 60 45 0,000 0,36115933 0,3827956 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,36749754 0,3893341 ! cell redox homeostasis GO:0045454 63 46 0,000 0,36749754 0,38915485 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,36749754 0,38897577 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,36749754 0,38879685 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,37377323 0,39525445 ! viral infectious cycle GO:0019058 71 47 0,000 0,37377323 0,39507281 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,37377323 0,39489133 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,37377323 0,39471002 ! chloride transport GO:0006821 67 48 0,000 0,37998701 0,40108771 ! response to temperature stimulus GO:0009266 62 48 0,000 0,37998701 0,40090372 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,37998701 0,40071991 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,37998701 0,40053626 ! nuclear export GO:0051168 69 48 0,000 0,37998701 0,40035278 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,37998701 0,40016947 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,38613948 0,40646261 ! sensory perception of smell GO:0007608 61 49 0,000 0,38613948 0,40627667 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,38613948 0,40609091 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,38613948 0,40590531 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,38613948 0,40571988 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,38613948 0,40553462 ! ear development GO:0043583 72 50 0,000 0,39223126 0,41174436 ! proton transport GO:0015992 75 50 0,000 0,39223126 0,41155652 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,39223126 0,41136885 ! positive regulation of secretion GO:0051047 71 51 0,000 0,39826292 0,41750443 ! hydrogen transport GO:0006818 77 51 0,000 0,39826292 0,41731422 ! adult behavior GO:0030534 80 51 0,000 0,39826292 0,41712419 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,40423507 0,42318646 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,41014828 0,42918155 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,41014828 0,42898638 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,41014828 0,42879139 ! single fertilization GO:0007338 59 53 0,000 0,41014828 0,42859657 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,41600314 0,43451736 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,42180022 0,44037245 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,42180022 0,44017264 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,43322329 0,45188824 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,43322329 0,45168339 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,43322329 0,45147873 ! developmental maturation GO:0021700 75 57 0,000 0,43322329 0,45127426 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,4388504 0,45692889 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,4388504 0,45672213 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,44442196 0,4623114 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,44442196 0,4621024 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,44442196 0,46189359 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,44993852 0,4674158 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,44993852 0,46720478 ! fertilization GO:0009566 68 60 0,000 0,44993852 0,46699395 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,45540061 0,47244989 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,45540061 0,47223688 ! extracellular matrix organization GO:0030198 103 61 0,000 0,45540061 0,47202407 ! amine catabolic process GO:0009310 90 62 0,000 0,46080878 0,4774145 ! neurotransmitter transport GO:0006836 81 62 0,000 0,46080878 0,47719955 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,46080878 0,47698479 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,46080878 0,47677022 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,46616355 0,4820936 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,47146545 0,48735754 ! defense response to bacterium GO:0042742 73 65 0,000 0,47671498 0,49256265 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,47671498 0,49234147 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,47671498 0,4921205 ! activation of immune response GO:0002253 83 65 0,000 0,47671498 0,49189971 ! antigen processing and presentation GO:0019882 96 66 0,000 0,48191268 0,49703999 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,48191268 0,4968172 ! regulation of immune effector process GO:0002697 101 66 0,000 0,48191268 0,49659461 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,48705905 0,501673 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,49215459 0,50669452 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,49215459 0,50646781 ! rhythmic process GO:0048511 105 68 0,000 0,49215459 0,5062413 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,49719979 0,51120229 ! response to metal ion GO:0010038 103 70 0,000 0,50219517 0,51610763 ! humoral immune response GO:0006959 86 70 0,000 0,50219517 0,51587713 ! muscle cell differentiation GO:0042692 104 71 0,000 0,5071412 0,52072533 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,5071412 0,52049297 ! regulation of blood pressure GO:0008217 107 73 0,000 0,51688715 0,53025889 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,51688715 0,53002249 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,52168803 0,53470698 ! digestion GO:0007586 97 74 0,000 0,52168803 0,5344688 ! response to inorganic substance GO:0010035 115 75 0,000 0,52644147 0,53909857 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,52644147 0,53885865 ! tRNA metabolic process GO:0006399 95 76 0,000 0,53114795 0,54343429 ! response to unfolded protein GO:0006986 99 76 0,000 0,53114795 0,54319266 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,53580792 0,54771476 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,53580792 0,54747144 ! protein ubiquitination GO:0016567 125 77 0,000 0,53580792 0,54722833 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,53580792 0,54698545 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,53580792 0,54674277 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,54042183 0,55120631 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,54042183 0,55096198 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,54499015 0,55537322 ! cellular respiration GO:0045333 107 79 0,000 0,54499015 0,55512726 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,54499015 0,55488152 ! regulation of lyase activity GO:0051339 133 79 0,000 0,54499015 0,554636 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,54499015 0,55439069 ! chromatin assembly GO:0031497 102 80 0,000 0,54951332 0,55874476 GO:0006334|nucleosome assembly, ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,55399178 0,56304954 ! mRNA transport GO:0051028 121 81 0,000 0,55399178 0,56280084 ! response to protein stimulus GO:0051789 111 81 0,000 0,55399178 0,56255236 ! vitamin metabolic process GO:0006766 103 81 0,000 0,55399178 0,56230411 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,56281634 0,57100908 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,56281634 0,57075731 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,5671633 0,57491212 ! sterol metabolic process GO:0016125 120 84 0,000 0,5671633 0,57465885 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,57146729 0,57876476 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,57572872 0,58282397 ! nucleosome organization GO:0034728 114 87 0,000 0,57994802 0,58683698 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,57994802 0,58657891 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,57994802 0,58632108 ! female pregnancy GO:0007565 130 87 0,000 0,57994802 0,58606347 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,5841256 0,59002586 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,5841256 0,58976685 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,5841256 0,58950807 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,5841256 0,58924951 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,58826187 0,5931619 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,58826187 0,59290197 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,59235724 0,59676813 ! hormone metabolic process GO:0042445 121 90 0,000 0,59235724 0,59650685 ! RNA localization GO:0006403 135 91 0,000 0,5964121 0,60032728 ! ATP metabolic process GO:0046034 137 91 0,000 0,5964121 0,60006467 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,60042686 0,60383987 ! positive regulation of immune response GO:0050778 121 92 0,000 0,60042686 0,60357595 ! electron transport chain GO:0022900 123 94 0,000 0,60833765 0,61126107 ! response to oxidative stress GO:0006979 141 94 0,000 0,60833765 0,61099414 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,6160927 0,61851297 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,6160927 0,61824311 ! protein maturation GO:0051604 129 96 0,000 0,6160927 0,61797349 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,61991278 0,62153418 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,61991278 0,62126336 ! calcium ion transport GO:0006816 167 99 0,000 0,62743994 0,62853304 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,63114775 0,63197206 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,63114775 0,63169705 ! divalent metal ion transport GO:0070838 171 100 0,000 0,63114775 0,63142228 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,63114775 0,63114775