pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6291-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! protein amino acid autophosphorylation GO:0046777 28 28 4,000 1,432E-06 2,638E-03 ! positive regulation of glucose metabolic process GO:0010907 5 5 2,000 3,576E-06 3,295E-03 ! positive regulation of cell migration GO:0030335 36 36 4,000 5,256E-06 3,229E-03 ! ER overload response GO:0006983 6 6 2,000 7,115E-06 3,278E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 2,000 7,115E-06 2,623E-03 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! positive regulation of cell motion GO:0051272 39 39 4,000 7,897E-06 2,426E-03 ! positive regulation of cellular catabolic process GO:0031331 7 7 2,000 1,239E-05 3,261E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 2,000 1,239E-05 2,854E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! axon cargo transport GO:0008088 7 7 2,000 1,239E-05 2,537E-03 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 3,000 1,349E-05 2,486E-03 ! DNA integrity checkpoint GO:0031570 21 21 3,000 1,349E-05 2,26E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 2,000 1,972E-05 3,028E-03 ! glucose homeostasis GO:0042593 24 24 3,000 2,357E-05 3,341E-03 GO:0033500|carbohydrate homeostasis, ! cell cycle arrest GO:0007050 49 49 4,000 2,477E-05 3,26E-03 ! positive regulation of MAP kinase activity GO:0043406 50 49 4,000 2,477E-05 3,043E-03 ! regulation of gene-specific transcription GO:0032583 25 25 3,000 2,791E-05 3,215E-03 ! regulation of intracellular protein transport GO:0033157 25 25 3,000 2,791E-05 3,026E-03 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 2,000 2,943E-05 3,013E-03 ! positive regulation of endothelial cell proliferation GO:0001938 9 9 2,000 2,943E-05 2,854E-03 ! induction of apoptosis by intracellular signals GO:0008629 26 26 3,000 3,281E-05 3,023E-03 ! heart development GO:0007507 90 87 5,000 3,496E-05 3,068E-03 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 3,000 3,831E-05 3,209E-03 ! regulation of glucose metabolic process GO:0010906 10 10 2,000 4,182E-05 3,351E-03 ! microtubule-based transport GO:0010970 11 11 2,000 5,721E-05 4,393E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 2,000 5,721E-05 4,218E-03 GO:0032388|positive regulation of intracellular transport, ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 2,000 5,721E-05 4,055E-03 ! regulation of monooxygenase activity GO:0032768 11 11 2,000 5,721E-05 3,905E-03 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 2,000 5,721E-05 3,766E-03 GO:0006109|regulation of carbohydrate metabolic process, ! regulation of DNA replication GO:0006275 32 31 3,000 6,722E-05 4,272E-03 ! regulation of intracellular transport GO:0032386 31 31 3,000 6,722E-05 4,13E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 2,000 9,815E-05 5,835E-03 ! negative regulation of DNA replication GO:0008156 13 13 2,000 9,815E-05 5,653E-03 ! response to endoplasmic reticulum stress GO:0034976 13 13 2,000 9,815E-05 5,482E-03 ! protein tetramerization GO:0051262 13 13 2,000 9,815E-05 5,32E-03 ! regulation of MAP kinase activity GO:0043405 67 66 4,000 1,058E-04 5,57E-03 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 1,243E-04 6,363E-03 ! lung development GO:0030324 38 37 3,000 1,366E-04 6,806E-03 ! regulation of cell migration GO:0030334 71 71 4,000 1,5E-04 7,273E-03 ! negative regulation of kinase activity GO:0033673 38 38 3,000 1,519E-04 7,179E-03 ! protein import into nucleus, translocation GO:0000060 15 15 2,000 1,546E-04 7,121E-03 ! insulin receptor signaling pathway GO:0008286 17 15 2,000 1,546E-04 6,948E-03 ! ER-nuclear signaling pathway GO:0006984 15 15 2,000 1,546E-04 6,782E-03 ! respiratory tube development GO:0030323 40 39 3,000 1,684E-04 7,216E-03 ! respiratory system development GO:0060541 40 39 3,000 1,684E-04 7,052E-03 ! protein oligomerization GO:0051259 39 39 3,000 1,684E-04 6,895E-03 ! negative regulation of transferase activity GO:0051348 40 40 3,000 1,861E-04 7,455E-03 ! positive regulation of catabolic process GO:0009896 16 16 2,000 1,893E-04 7,421E-03 ! cell cycle checkpoint GO:0000075 42 41 3,000 2,051E-04 7,875E-03 ! cell morphogenesis involved in differentiation GO:0000904 82 77 4,000 2,202E-04 8,284E-03 ! cell-substrate adhesion GO:0031589 43 42 3,000 2,255E-04 8,311E-03 ! cell junction assembly GO:0034329 18 17 2,000 2,286E-04 8,262E-03 ! tissue remodeling GO:0048771 17 17 2,000 2,286E-04 8,103E-03 ! regulation of oxidoreductase activity GO:0051341 17 17 2,000 2,286E-04 7,95E-03 ! embryonic organ development GO:0048568 17 17 2,000 2,286E-04 7,803E-03 ! regulation of locomotion GO:0040012 79 79 4,000 2,485E-04 8,327E-03 ! regulation of cell motion GO:0051270 79 79 4,000 2,485E-04 8,178E-03 ! regulation of cellular catabolic process GO:0031329 18 18 2,000 2,73E-04 8,826E-03 ! cellular response to hormone stimulus GO:0032870 48 46 3,000 3,218E-04 0,01022449 ! negative regulation of DNA metabolic process GO:0051053 19 19 2,000 3,225E-04 0,01007352 ! cellular response to oxidative stress GO:0034599 19 19 2,000 3,225E-04 9,906E-03 ! DNA damage checkpoint GO:0000077 19 19 2,000 3,225E-04 9,743E-03 ! regulation of endothelial cell proliferation GO:0001936 19 19 2,000 3,225E-04 9,586E-03 ! placenta development GO:0001890 19 19 2,000 3,225E-04 9,434E-03 ! positive regulation of protein kinase activity GO:0045860 89 86 4,000 3,696E-04 0,01064387 ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 2,000 3,775E-04 0,0107023 ! positive regulation of gene-specific transcription GO:0043193 20 20 2,000 3,775E-04 0,01054015 ! gland development GO:0048732 51 49 3,000 4,111E-04 0,01130936 ! skeletal muscle tissue development GO:0007519 50 49 3,000 4,111E-04 0,01114305 GO:0060538|skeletal muscle organ development, ! positive regulation of transferase activity GO:0051347 91 88 4,000 4,113E-04 0,01098515 GO:0033674|positive regulation of kinase activity, ! mitotic sister chromatid segregation GO:0000070 21 21 2,000 4,381E-04 0,01153497 ! mammary gland development GO:0030879 23 21 2,000 4,381E-04 0,0113725 ! cellular response to insulin stimulus GO:0032869 23 21 2,000 4,381E-04 0,01121455 ! regulation of DNA metabolic process GO:0051052 51 50 3,000 4,445E-04 0,01122234 ! interphase of mitotic cell cycle GO:0051329 52 51 3,000 4,798E-04 0,01194891 GO:0051325|interphase, ! positive regulation of transcription factor activity GO:0051091 22 22 2,000 5,047E-04 0,01240223 GO:0090047|positive regulation of transcription regulator activity, ! sister chromatid segregation GO:0000819 22 22 2,000 5,047E-04 0,01223904 ! cell junction organization GO:0034330 23 22 2,000 5,047E-04 0,01208009 ! neuron fate specification GO:0048665 5 5 1,000 5,105E-04 0,01206174 ! hemoglobin biosynthetic process GO:0042541 5 5 1,000 5,105E-04 0,01190906 ! prostate gland development GO:0030850 5 5 1,000 5,105E-04 0,0117602 ! forebrain regionalization GO:0021871 5 5 1,000 5,105E-04 0,01161501 ! mRNA stabilization GO:0048255 5 5 1,000 5,105E-04 0,01147337 GO:0043489|RNA stabilization, ! heart looping GO:0001947 5 5 1,000 5,105E-04 0,01133513 ! endocrine pancreas development GO:0031018 5 5 1,000 5,105E-04 0,01120019 ! regulation of phospholipase A2 activity GO:0032429 5 5 1,000 5,105E-04 0,01106842 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 1,000 5,105E-04 0,01093972 ! protein heterooligomerization GO:0051291 5 5 1,000 5,105E-04 0,01081398 ! regulation of mitochondrial membrane potential GO:0051881 5 5 1,000 5,105E-04 0,01069109 ! positive regulation of monooxygenase activity GO:0032770 5 5 1,000 5,105E-04 0,01057097 ! spinal cord motor neuron differentiation GO:0021522 5 5 1,000 5,105E-04 0,01045351 GO:0021517|ventral spinal cord development, ! T cell lineage commitment GO:0002360 5 5 1,000 5,105E-04 0,01033864 ! regulation of hormone metabolic process GO:0032350 5 5 1,000 5,105E-04 0,01022626 ! regulation of DNA replication initiation GO:0030174 5 5 1,000 5,105E-04 0,0101163 ! peptidyl-lysine modification GO:0018205 5 5 1,000 5,105E-04 0,01000868 ! negative regulation of neuroblast proliferation GO:0007406 5 5 1,000 5,105E-04 9,903E-03 ! positive regulation of erythrocyte differentiation GO:0045648 5 5 1,000 5,105E-04 9,8E-03 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 5,105E-04 9,699E-03 GO:0007439|ectodermal gut development, ! embryonic gut development GO:0048566 5 5 1,000 5,105E-04 9,6E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 1,000 5,105E-04 9,503E-03 ! response to hypoxia GO:0001666 53 53 3,000 5,562E-04 0,01025099 ! regulation of protein transport GO:0051223 53 53 3,000 5,562E-04 0,01014949 GO:0070201|regulation of establishment of protein localization, ! response to oxygen levels GO:0070482 55 54 3,000 5,975E-04 0,01079621 ! regulation of protein localization GO:0032880 58 57 3,000 7,345E-04 0,01314193 ! response to hormone stimulus GO:0009725 102 100 4,000 7,404E-04 0,01311997 ! positive regulation of DNA binding GO:0043388 26 25 2,000 7,423E-04 0,01302911 ! heart morphogenesis GO:0003007 25 25 2,000 7,423E-04 0,01290619 ! N-terminal protein amino acid modification GO:0031365 6 6 1,000 7,622E-04 0,01312774 GO:0018409|peptide or protein amino-terminal blocking, ! virus-host interaction GO:0019048 6 6 1,000 7,622E-04 0,01300618 ! regulation of positive chemotaxis GO:0050926 6 6 1,000 7,622E-04 0,01288686 GO:0050927|positive regulation of positive chemotaxis, ! nerve growth factor receptor signaling pathway GO:0048011 6 6 1,000 7,622E-04 0,01276971 ! focal adhesion formation GO:0048041 7 6 1,000 7,622E-04 0,01265466 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 7,622E-04 0,01254168 GO:0070667|negative regulation of mast cell proliferation, ! regulation of vascular permeability GO:0043114 6 6 1,000 7,622E-04 0,01243069 ! peptidyl-serine phosphorylation GO:0018105 6 6 1,000 7,622E-04 0,01232165 ! regulation of bone resorption GO:0045124 6 6 1,000 7,622E-04 0,0122145 ! G1 DNA damage checkpoint GO:0031571 6 6 1,000 7,622E-04 0,01210921 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 7,622E-04 0,01200571 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 7,622E-04 0,01190396 ! regulation of embryonic development GO:0045995 6 6 1,000 7,622E-04 0,01180393 ! localization within membrane GO:0051668 6 6 1,000 7,622E-04 0,01170556 ! positive regulation of binding GO:0051099 27 26 2,000 8,348E-04 0,0127158 ! response to insulin stimulus GO:0032868 28 26 2,000 8,348E-04 0,01261157 ! peptidyl-amino acid modification GO:0018193 61 59 3,000 8,373E-04 0,01254533 ! axonogenesis GO:0007409 66 62 3,000 1,01E-03 0,01501067 ! regulation of chemokine production GO:0032642 7 7 1,000 1,062E-03 0,01565922 ! digestive system development GO:0055123 7 7 1,000 1,062E-03 0,01553494 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! hemoglobin metabolic process GO:0020027 7 7 1,000 1,062E-03 0,01541262 ! cell differentiation in spinal cord GO:0021515 7 7 1,000 1,062E-03 0,01529221 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 1,062E-03 0,01517367 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! response to X-ray GO:0010165 7 7 1,000 1,062E-03 0,01505695 ! regulation of intracellular pH GO:0051453 7 7 1,000 1,062E-03 0,01494201 ! myofibril assembly GO:0030239 7 7 1,000 1,062E-03 0,01482881 GO:0055002|striated muscle cell development, ! eating behavior GO:0042755 7 7 1,000 1,062E-03 0,01471732 ! cranial nerve development GO:0021545 7 7 1,000 1,062E-03 0,01460749 ! platelet activation GO:0030168 8 7 1,000 1,062E-03 0,01449928 ! response to gamma radiation GO:0010332 8 7 1,000 1,062E-03 0,01439267 ! regulation of mRNA stability GO:0043488 7 7 1,000 1,062E-03 0,01428761 ! negative regulation of T cell activation GO:0050868 7 7 1,000 1,062E-03 0,01418408 ! positive regulation of cell cycle GO:0045787 29 29 2,000 1,155E-03 0,01531975 ! regulation of epithelial cell proliferation GO:0050678 29 29 2,000 1,155E-03 0,01521032 ! positive regulation of protein transport GO:0051222 29 29 2,000 1,155E-03 0,01510245 ! response to UV GO:0009411 29 29 2,000 1,155E-03 0,01499609 ! positive regulation of response to external stimulus GO:0032103 30 30 2,000 1,277E-03 0,01646151 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 3,000 1,351E-03 0,01729315 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! striated muscle tissue development GO:0014706 69 67 3,000 1,351E-03 0,01717388 ! skeletal muscle fiber development GO:0048741 31 31 2,000 1,407E-03 0,01775984 ! negative regulation of bone remodeling GO:0046851 8 8 1,000 1,41E-03 0,01767182 ! adult walking behavior GO:0007628 8 8 1,000 1,41E-03 0,01755241 ! pancreas development GO:0031016 8 8 1,000 1,41E-03 0,01743461 ! cell-cell junction assembly GO:0007043 8 8 1,000 1,41E-03 0,01731838 ! positive regulation of endothelial cell migration GO:0010595 8 8 1,000 1,41E-03 0,01720369 ! sex determination GO:0007530 8 8 1,000 1,41E-03 0,01709051 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 1,000 1,41E-03 0,01697881 ! muscle cell development GO:0055001 8 8 1,000 1,41E-03 0,01686855 ! peptidyl-serine modification GO:0018209 8 8 1,000 1,41E-03 0,01675972 ! positive regulation of leukocyte migration GO:0002687 8 8 1,000 1,41E-03 0,01665229 ! regulation of RNA stability GO:0043487 8 8 1,000 1,41E-03 0,01654622 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 1,41E-03 0,0164415 ! cell redox homeostasis GO:0045454 32 32 2,000 1,545E-03 0,01790315 ! muscle fiber development GO:0048747 32 32 2,000 1,545E-03 0,01779126 ! positive regulation of transport GO:0051050 71 70 3,000 1,591E-03 0,01820914 ! cell part morphogenesis GO:0032990 75 70 3,000 1,591E-03 0,01809673 ! wound healing GO:0042060 74 70 3,000 1,591E-03 0,01798571 ! growth GO:0040007 70 70 3,000 1,591E-03 0,01787604 ! muscle tissue development GO:0060537 72 70 3,000 1,591E-03 0,0177677 ! negative regulation of cell cycle process GO:0010948 9 9 1,000 1,804E-03 0,02002698 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 1,000 1,804E-03 0,01990706 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 1,804E-03 0,01978856 GO:0060675|ureteric bud morphogenesis, ! positive regulation of protein import into nucleus GO:0042307 9 9 1,000 1,804E-03 0,01967147 ! DNA replication initiation GO:0006270 9 9 1,000 1,804E-03 0,01955576 ! regulation of cellular pH GO:0030641 9 9 1,000 1,804E-03 0,0194414 ! histone acetylation GO:0016573 9 9 1,000 1,804E-03 0,01932836 ! positive regulation of oxidoreductase activity GO:0051353 9 9 1,000 1,804E-03 0,01921664 ! negative regulation of tissue remodeling GO:0034104 9 9 1,000 1,804E-03 0,0191062 ! regulation of leukocyte migration GO:0002685 9 9 1,000 1,804E-03 0,01899702 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 1,000 1,804E-03 0,01888908 ! regulation of angiogenesis GO:0045765 35 34 2,000 1,845E-03 0,01920573 ! response to peptide hormone stimulus GO:0043434 36 34 2,000 1,845E-03 0,01909783 ! integrin-mediated signaling pathway GO:0007229 36 36 2,000 2,178E-03 0,0224299 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 2,244E-03 0,02297961 ! cell-substrate junction assembly GO:0007044 11 10 1,000 2,244E-03 0,02285265 ! neuromuscular junction development GO:0007528 10 10 1,000 2,244E-03 0,02272708 ! intermediate filament cytoskeleton organization GO:0045104 10 10 1,000 2,244E-03 0,02260289 ! regulation of erythrocyte differentiation GO:0045646 10 10 1,000 2,244E-03 0,02248005 ! nerve development GO:0021675 10 10 1,000 2,244E-03 0,02235854 ! epithelial to mesenchymal transition GO:0001837 10 10 1,000 2,244E-03 0,02223833 ! gut development GO:0048565 10 10 1,000 2,244E-03 0,02211941 ! embryonic organ morphogenesis GO:0048562 10 10 1,000 2,244E-03 0,02200175 ! positive regulation of neuron apoptosis GO:0043525 10 10 1,000 2,244E-03 0,02188534 ! negative regulation of homeostatic process GO:0032845 10 10 1,000 2,244E-03 0,02177015 ! regulation of transcription factor activity GO:0051090 38 37 2,000 2,359E-03 0,02275911 GO:0090046|regulation of transcription regulator activity, ! meiosis GO:0007126 37 37 2,000 2,359E-03 0,02264058 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of protein kinase activity GO:0006469 37 37 2,000 2,359E-03 0,02252327 ! response to drug GO:0042493 37 37 2,000 2,359E-03 0,02240717 ! negative regulation of growth GO:0045926 37 37 2,000 2,359E-03 0,02229226 ! DNA damage response, signal transduction GO:0042770 37 37 2,000 2,359E-03 0,02217852 ! microtubule-based movement GO:0007018 82 78 3,000 2,372E-03 0,02218629 ! nuclear transport GO:0051169 79 79 3,000 2,485E-03 0,02312817 GO:0006913|nucleocytoplasmic transport, ! cell-matrix adhesion GO:0007160 39 38 2,000 2,548E-03 0,02359595 ! chromosome segregation GO:0007059 38 38 2,000 2,548E-03 0,02347797 ! urogenital system development GO:0001655 38 38 2,000 2,548E-03 0,02336116 ! meiotic cell cycle GO:0051321 38 38 2,000 2,548E-03 0,02324551 ! regulation of homeostatic process GO:0032844 38 38 2,000 2,548E-03 0,023131 ! neuron projection development GO:0031175 85 80 3,000 2,602E-03 0,02350405 ! tube development GO:0035295 83 81 3,000 2,722E-03 0,02447392 ! positive regulation of hormone secretion GO:0046887 11 11 1,000 2,73E-03 0,02442759 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 1,000 2,73E-03 0,02430958 ! protein amino acid acetylation GO:0006473 11 11 1,000 2,73E-03 0,0241927 ! spinal cord development GO:0021510 11 11 1,000 2,73E-03 0,02407695 ! cellular response to starvation GO:0009267 11 11 1,000 2,73E-03 0,0239623 ! response to lipopolysaccharide GO:0032496 11 11 1,000 2,73E-03 0,02384873 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 1,000 2,73E-03 0,02373624 ! G1/S transition checkpoint GO:0031575 12 11 1,000 2,73E-03 0,0236248 ! intermediate filament-based process GO:0045103 11 11 1,000 2,73E-03 0,0235144 ! interaction with host GO:0051701 11 11 1,000 2,73E-03 0,02340504 ! muscle maintenance GO:0046716 12 11 1,000 2,73E-03 0,02329668 ! proximal/distal pattern formation GO:0009954 11 11 1,000 2,73E-03 0,02318932 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 2,73E-03 0,02308295 ! activation of MAPK activity GO:0000187 39 39 2,000 2,746E-03 0,02310975 ! regulation of cellular localization GO:0060341 86 85 3,000 3,243E-03 0,02717018 ! positive regulation of angiogenesis GO:0045766 12 12 1,000 3,261E-03 0,02719695 ! collagen metabolic process GO:0032963 12 12 1,000 3,261E-03 0,02707444 ! cellular response to hydrogen peroxide GO:0070301 12 12 1,000 3,261E-03 0,02695303 GO:0042744|hydrogen peroxide catabolic process, ! actomyosin structure organization GO:0031032 12 12 1,000 3,261E-03 0,02683271 ! mitotic chromosome condensation GO:0007076 12 12 1,000 3,261E-03 0,02671345 ! regulation of insulin secretion GO:0050796 12 12 1,000 3,261E-03 0,02659525 ! regulation of chromosome organization GO:0033044 12 12 1,000 3,261E-03 0,02647809 ! somitogenesis GO:0001756 13 12 1,000 3,261E-03 0,02636196 ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 1,000 3,261E-03 0,02624684 ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 1,000 3,261E-03 0,02613272 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 1,000 3,261E-03 0,02601959 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 3,000 3,384E-03 0,02687842 ! mitochondrion organization GO:0007005 44 43 2,000 3,633E-03 0,02874005 ! positive regulation of DNA replication GO:0045740 14 13 1,000 3,836E-03 0,03021564 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 1,000 3,836E-03 0,03008706 ! negative regulation of hormone secretion GO:0046888 13 13 1,000 3,836E-03 0,02995957 ! vasculogenesis GO:0001570 13 13 1,000 3,836E-03 0,02983316 ! mitochondrial membrane organization GO:0007006 13 13 1,000 3,836E-03 0,02970781 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 1,000 3,836E-03 0,02958351 ! response to corticosteroid stimulus GO:0031960 13 13 1,000 3,836E-03 0,02946024 GO:0051384|response to glucocorticoid stimulus, ! actin filament bundle formation GO:0051017 13 13 1,000 3,836E-03 0,029338 ! ureteric bud development GO:0001657 13 13 1,000 3,836E-03 0,02921677 ! cell aging GO:0007569 13 13 1,000 3,836E-03 0,02909654 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 1,000 3,836E-03 0,02897729 ! regulation of endothelial cell migration GO:0010594 13 13 1,000 3,836E-03 0,02885902 ! coenzyme catabolic process GO:0009109 13 13 1,000 3,836E-03 0,0287417 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! regulation of peptide secretion GO:0002791 13 13 1,000 3,836E-03 0,02862534 ! positive regulation of locomotion GO:0040017 13 13 1,000 3,836E-03 0,02850991 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! neural crest cell migration GO:0001755 14 13 1,000 3,836E-03 0,02839542 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 3,836E-03 0,02828184 ! cell-cell junction organization GO:0045216 13 13 1,000 3,836E-03 0,02816916 ! camera-type eye morphogenesis GO:0048593 13 13 1,000 3,836E-03 0,02805738 ! protein import into nucleus GO:0006606 44 44 2,000 3,88E-03 0,0282606 ! regulation of DNA binding GO:0051101 47 45 2,000 4,136E-03 0,03000692 ! nuclear import GO:0051170 45 45 2,000 4,136E-03 0,02988925 ! Wnt receptor signaling pathway GO:0016055 46 45 2,000 4,136E-03 0,02977249 ! regulation of membrane potential GO:0042391 46 46 2,000 4,402E-03 0,03156473 ! neuron fate commitment GO:0048663 14 14 1,000 4,455E-03 0,03182439 ! acetyl-CoA metabolic process GO:0006084 14 14 1,000 4,455E-03 0,03170152 ! cellular iron ion homeostasis GO:0006879 14 14 1,000 4,455E-03 0,03157959 ! protein amino acid acylation GO:0043543 14 14 1,000 4,455E-03 0,03145859 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 1,000 4,455E-03 0,03133852 ! regulation of behavior GO:0050795 14 14 1,000 4,455E-03 0,03121937 ! base-excision repair GO:0006284 14 14 1,000 4,455E-03 0,03110111 ! positive regulation of inflammatory response GO:0050729 14 14 1,000 4,455E-03 0,03098375 ! response to molecule of bacterial origin GO:0002237 14 14 1,000 4,455E-03 0,03086727 ! regulation of catabolic process GO:0009894 48 47 2,000 4,678E-03 0,03228942 ! actin filament organization GO:0007015 50 48 2,000 4,964E-03 0,03413951 ! protein localization in nucleus GO:0034504 48 48 2,000 4,964E-03 0,03401259 ! regulation of cell growth GO:0001558 97 96 3,000 5,019E-03 0,03426058 ! striated muscle cell differentiation GO:0051146 16 15 1,000 5,117E-03 0,03479724 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 1,000 5,117E-03 0,03466931 ! chromosome condensation GO:0030261 15 15 1,000 5,117E-03 0,03454232 ! response to starvation GO:0042594 15 15 1,000 5,117E-03 0,03441625 ! hydrogen peroxide metabolic process GO:0042743 15 15 1,000 5,117E-03 0,0342911 ! glutathione metabolic process GO:0006749 16 15 1,000 5,117E-03 0,03416686 ! response to ionizing radiation GO:0010212 16 15 1,000 5,117E-03 0,03404351 ! positive regulation of myeloid cell differentiation GO:0045639 16 15 1,000 5,117E-03 0,03392105 ! negative regulation of cell activation GO:0050866 15 15 1,000 5,117E-03 0,03379947 ! protein homooligomerization GO:0051260 15 15 1,000 5,117E-03 0,03367876 ! anterior/posterior pattern formation GO:0009952 51 50 2,000 5,569E-03 0,03652425 ! ectoderm development GO:0007398 99 99 3,000 5,598E-03 0,03658433 ! muscle organ development GO:0007517 102 100 3,000 5,8E-03 0,03777312 ! hemopoiesis GO:0030097 104 100 3,000 5,8E-03 0,03764012 ! positive regulation of mitosis GO:0045840 16 16 1,000 5,821E-03 0,03763991 GO:0051785|positive regulation of nuclear division, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 1,000 5,821E-03 0,03750831 ! cellular response to reactive oxygen species GO:0034614 16 16 1,000 5,821E-03 0,03737762 ! segmentation GO:0035282 17 16 1,000 5,821E-03 0,03724783 ! triglyceride metabolic process GO:0006641 16 16 1,000 5,821E-03 0,03711895 ! iron ion homeostasis GO:0055072 16 16 1,000 5,821E-03 0,03699095 ! cell fate specification GO:0001708 16 16 1,000 5,821E-03 0,03686383 ! cellular response to nutrient levels GO:0031669 16 16 1,000 5,821E-03 0,03673759 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 1,000 5,821E-03 0,0366122 ! cofactor catabolic process GO:0051187 16 16 1,000 5,821E-03 0,03648767 ! cell fate commitment GO:0045165 52 52 2,000 6,216E-03 0,03883196 ! response to light stimulus GO:0009416 53 52 2,000 6,216E-03 0,03870077 ! regulation of fibroblast proliferation GO:0048145 17 17 1,000 6,566E-03 0,04074582 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 1,000 6,566E-03 0,04060909 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 1,000 6,566E-03 0,04047328 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 6,566E-03 0,04033836 ! myelination GO:0042552 17 17 1,000 6,566E-03 0,04020435 ! glucose transport GO:0015758 17 17 1,000 6,566E-03 0,04007122 ! embryonic skeletal system morphogenesis GO:0048704 17 17 1,000 6,566E-03 0,03993897 ! neural crest cell development GO:0014032 19 17 1,000 6,566E-03 0,0398076 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 18 17 1,000 6,566E-03 0,03967708 GO:0050768|negative regulation of neurogenesis, ! cell recognition GO:0008037 18 17 1,000 6,566E-03 0,03954742 ! adult locomotory behavior GO:0008344 17 17 1,000 6,566E-03 0,0394186 ! liver development GO:0001889 17 17 1,000 6,566E-03 0,03929061 ! microtubule cytoskeleton organization GO:0000226 55 55 2,000 7,267E-03 0,04334382 ! in utero embryonic development GO:0001701 55 55 2,000 7,267E-03 0,043204 ! protein modification by small protein conjugation or removal GO:0070647 56 55 2,000 7,267E-03 0,04306508 ! meiosis I GO:0007127 18 18 1,000 7,353E-03 0,0434337 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 1,000 7,353E-03 0,04329494 ! hexose transport GO:0008645 18 18 1,000 7,353E-03 0,04315705 GO:0015749|monosaccharide transport, ! cholesterol homeostasis GO:0042632 18 18 1,000 7,353E-03 0,04302005 GO:0055092|sterol homeostasis, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 1,000 7,353E-03 0,04288391 ! neutral lipid metabolic process GO:0006638 18 18 1,000 7,353E-03 0,04274863 GO:0006639|acylglycerol metabolic process, ! telencephalon development GO:0021537 19 18 1,000 7,353E-03 0,0426142 ! B cell differentiation GO:0030183 18 18 1,000 7,353E-03 0,04248061 ! cellular response to extracellular stimulus GO:0031668 18 18 1,000 7,353E-03 0,04234786 ! ensheathment of neurons GO:0007272 18 18 1,000 7,353E-03 0,04221593 GO:0008366|axon ensheathment, ! regulation of microtubule-based process GO:0032886 18 18 1,000 7,353E-03 0,04208483 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 1,000 7,353E-03 0,04195454 ! reproductive developmental process GO:0003006 56 56 2,000 7,64E-03 0,04345594 ! regulation of binding GO:0051098 60 57 2,000 8,023E-03 0,04549763 ! regulation of pH GO:0006885 19 19 1,000 8,18E-03 0,04624437 ! feeding behavior GO:0007631 19 19 1,000 8,18E-03 0,04610295 ! multicellular organismal metabolic process GO:0044236 19 19 1,000 8,18E-03 0,04596239 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 8,18E-03 0,04582269 ! metanephros development GO:0001656 19 19 1,000 8,18E-03 0,04568383 ! peripheral nervous system development GO:0007422 19 19 1,000 8,18E-03 0,04554582 ! dorsal/ventral pattern formation GO:0009953 19 19 1,000 8,18E-03 0,04540863 ! eye morphogenesis GO:0048592 19 19 1,000 8,18E-03 0,04527227 ! regulation of cell shape GO:0008360 21 19 1,000 8,18E-03 0,04513672 ! protein localization in organelle GO:0033365 59 59 2,000 8,824E-03 0,04854586 ! organic ether metabolic process GO:0018904 20 20 1,000 9,047E-03 0,04962335 GO:0006662|glycerol ether metabolic process, ! neural tube development GO:0021915 21 20 1,000 9,047E-03 0,0494761 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 9,047E-03 0,04932972 ! regulation of protein import into nucleus GO:0042306 21 21 1,000 9,953E-03 0,05411077 ! regulation of action potential in neuron GO:0019228 21 21 1,000 9,953E-03 0,05395162 ! regulation of multicellular organism growth GO:0040014 21 21 1,000 9,953E-03 0,0537934 ! negative regulation of hydrolase activity GO:0051346 21 21 1,000 9,953E-03 0,05363611 ! protein import GO:0017038 62 62 2,000 0,01011084 0,05432734 ! positive regulation of DNA metabolic process GO:0051054 23 22 1,000 0,01089793 0,0583863 ! odontogenesis GO:0042476 22 22 1,000 0,01089793 0,05821707 ! hormone-mediated signaling GO:0009755 22 22 1,000 0,01089793 0,05804881 ! embryonic skeletal system development GO:0048706 22 22 1,000 0,01089793 0,05788152 ! spindle organization GO:0007051 22 22 1,000 0,01089793 0,05771519 ! aerobic respiration GO:0009060 22 22 1,000 0,01089793 0,05754982 ! cytokine production GO:0001816 22 22 1,000 0,01089793 0,05738539 ! cytokinesis GO:0000910 23 22 1,000 0,01089793 0,0572219 ! regulation of response to external stimulus GO:0032101 65 64 2,000 0,01102625 0,05773121 ! response to hydrogen peroxide GO:0042542 24 23 1,000 0,01188083 0,0620294 ! regulation of hormone secretion GO:0046883 23 23 1,000 0,01188083 0,06185418 ! mitotic cell cycle checkpoint GO:0007093 24 23 1,000 0,01188083 0,06167994 ! endocrine system development GO:0035270 23 23 1,000 0,01188083 0,06150668 ! positive regulation of growth GO:0045927 23 23 1,000 0,01188083 0,06133439 ! monovalent inorganic cation homeostasis GO:0055067 23 23 1,000 0,01188083 0,06116307 ! lipid homeostasis GO:0055088 23 23 1,000 0,01188083 0,0609927 ! calcium-mediated signaling GO:0019722 23 23 1,000 0,01188083 0,06082327 ! negative regulation of cell differentiation GO:0045596 68 67 2,000 0,01248689 0,06374886 ! mitochondrial transport GO:0006839 24 24 1,000 0,01290122 0,06568219 ! regulation of action potential GO:0001508 24 24 1,000 0,01290122 0,06550125 ! T cell differentiation GO:0030217 24 24 1,000 0,01290122 0,0653213 ! androgen receptor signaling pathway GO:0030521 24 24 1,000 0,01290122 0,06514234 ! epithelial tube morphogenesis GO:0060562 25 24 1,000 0,01290122 0,06496435 ! glucan metabolic process GO:0044042 25 24 1,000 0,01290122 0,06478734 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! response to radiation GO:0009314 70 68 2,000 0,0129973 0,06509246 ! regulation of cell size GO:0008361 68 68 2,000 0,0129973 0,06491606 ! regionalization GO:0003002 70 69 2,000 0,01351955 0,06734198 ! regulation of mitotic cell cycle GO:0007346 72 69 2,000 0,01351955 0,06716046 ! negative regulation of secretion GO:0051048 26 25 1,000 0,01395852 0,06915471 ! regulation of T cell proliferation GO:0042129 25 25 1,000 0,01395852 0,06896931 ! negative regulation of immune system process GO:0002683 25 25 1,000 0,01395852 0,0687849 ! positive regulation of cytokine production GO:0001819 25 25 1,000 0,01395852 0,06860147 ! positive regulation of defense response GO:0031349 26 26 1,000 0,01505216 0,0737796 ! glycolysis GO:0006096 26 26 1,000 0,01505216 0,0735839 ! regulation of T cell differentiation GO:0045580 26 26 1,000 0,01505216 0,07338924 ! double-strand break repair GO:0006302 27 26 1,000 0,01505216 0,0731956 ! synapse organization GO:0050808 26 26 1,000 0,01505216 0,07300298 ! positive regulation of hydrolase activity GO:0051345 72 72 2,000 0,01515771 0,07332195 ! energy reserve metabolic process GO:0006112 28 27 1,000 0,01618158 0,07806977 ! peptide metabolic process GO:0006518 29 27 1,000 0,01618158 0,07786593 ! activation of caspase activity GO:0006919 27 27 1,000 0,01618158 0,07766316 ! mesenchymal cell development GO:0014031 29 27 1,000 0,01618158 0,07746144 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! cell growth GO:0016049 27 27 1,000 0,01618158 0,07726076 ! coenzyme metabolic process GO:0006732 75 74 2,000 0,01630966 0,07767108 ! response to oxidative stress GO:0006979 76 75 2,000 0,01690368 0,08029248 ! neuromuscular process GO:0050905 28 28 1,000 0,01734622 0,08218276 ! carbohydrate transport GO:0008643 28 28 1,000 0,01734622 0,08197203 ! histone modification GO:0016570 28 28 1,000 0,01734622 0,08176238 ! developmental growth GO:0048589 28 28 1,000 0,01734622 0,08155381 ! regulation of mast cell proliferation GO:0070666 28 28 1,000 0,01734622 0,08134629 ! cartilage development GO:0051216 29 28 1,000 0,01734622 0,08113983 ! viral reproductive process GO:0022415 29 29 1,000 0,01854554 0,08653022 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 0,01854554 0,08631171 ! regulation of lymphocyte proliferation GO:0050670 29 29 1,000 0,01854554 0,0860943 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! DNA-dependent DNA replication GO:0006261 29 29 1,000 0,01854554 0,08587798 ! covalent chromatin modification GO:0016569 29 29 1,000 0,01854554 0,08566275 ! adult behavior GO:0030534 30 29 1,000 0,01854554 0,08544859 ! response to reactive oxygen species GO:0000302 31 30 1,000 0,01977899 0,09090444 ! positive regulation of peptidase activity GO:0010952 30 30 1,000 0,01977899 0,09067831 GO:0043280|positive regulation of caspase activity, ! activation of phospholipase C activity GO:0007202 30 30 1,000 0,01977899 0,09045331 GO:0010863|positive regulation of phospholipase C activity, ! skeletal system morphogenesis GO:0048705 31 30 1,000 0,01977899 0,09022941 ! vascular process in circulatory system GO:0003018 31 30 1,000 0,01977899 0,09000662 ! regulation of inflammatory response GO:0050727 30 30 1,000 0,01977899 0,08978493 ! establishment of organelle localization GO:0051656 31 30 1,000 0,01977899 0,08956433 ! MAPKKK cascade GO:0000165 82 81 2,000 0,02072169 0,09360311 ! B cell activation GO:0042113 31 31 1,000 0,02104603 0,09483579 ! positive regulation of phospholipase activity GO:0010518 31 31 1,000 0,02104603 0,09460448 ! aging GO:0007568 32 31 1,000 0,02104603 0,0943743 ! camera-type eye development GO:0043010 31 31 1,000 0,02104603 0,09414524 ! regulation of myeloid cell differentiation GO:0045637 32 31 1,000 0,02104603 0,09391728 ! negative regulation of cell growth GO:0030308 32 32 1,000 0,02234613 0,09947807 ! glucose catabolic process GO:0006007 32 32 1,000 0,02234613 0,09923836 ! regulation of phospholipase activity GO:0010517 32 32 1,000 0,02234613 0,09899981 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 1,000 0,02234613 0,0987624 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 0,02234613 0,09852612 ! nuclear export GO:0051168 32 32 1,000 0,02234613 0,09829098 ! regulation of lymphocyte differentiation GO:0045619 32 32 1,000 0,02234613 0,09805695 ! kidney development GO:0001822 32 32 1,000 0,02234613 0,09782404 ! positive regulation of lipase activity GO:0060193 32 32 1,000 0,02234613 0,09759223 ! positive regulation of response to stimulus GO:0048584 86 85 2,000 0,02350985 0,10243181 ! negative regulation of cell size GO:0045792 33 33 1,000 0,02367876 0,10292443 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 0,02367876 0,10268225 ! regulation of bone remodeling GO:0046850 34 34 1,000 0,0250434 0,10834505 ! muscle cell differentiation GO:0042692 35 34 1,000 0,0250434 0,10809132 ! cellular polysaccharide metabolic process GO:0044264 35 34 1,000 0,0250434 0,10783877 ! viral reproduction GO:0016032 34 34 1,000 0,0250434 0,10758739 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 1,000 0,02643954 0,1133211 ! mesoderm development GO:0007498 35 35 1,000 0,02643954 0,11305817 ! multicellular organism reproduction GO:0032504 36 35 1,000 0,02643954 0,11279646 GO:0048609|reproductive process in a multicellular organism, ! regulation of cell morphogenesis GO:0022604 38 35 1,000 0,02643954 0,11253596 ! positive regulation of phosphorylation GO:0042327 35 35 1,000 0,02643954 0,11227666 ! regulation of tissue remodeling GO:0034103 35 35 1,000 0,02643954 0,11201855 ! response to steroid hormone stimulus GO:0048545 35 35 1,000 0,02643954 0,11176163 ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 1,000 0,02786666 0,11752461 ! regulation of mitosis GO:0007088 37 36 1,000 0,02786666 0,11725629 GO:0051783|regulation of nuclear division, ! embryonic limb morphogenesis GO:0030326 36 36 1,000 0,02786666 0,11698919 GO:0035113|embryonic appendage morphogenesis, ! positive regulation of phosphorus metabolic process GO:0010562 36 36 1,000 0,02786666 0,11672331 GO:0045937|positive regulation of phosphate metabolic process, ! positive regulation of organelle organization GO:0010638 36 36 1,000 0,02786666 0,11645863 ! regulation of lipase activity GO:0060191 36 36 1,000 0,02786666 0,11619515 ! coagulation GO:0050817 39 36 1,000 0,02786666 0,11593285 GO:0007596|blood coagulation, ! negative regulation of cell cycle GO:0045786 92 91 2,000 0,02805703 0,11646197 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 2,000 0,02885742 0,1195151 ! eye development GO:0001654 37 37 1,000 0,02932426 0,12117626 ! regulation of Rho protein signal transduction GO:0035023 37 37 1,000 0,02932426 0,12090517 ! adaptive immune response GO:0002250 37 37 1,000 0,02932426 0,1206353 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! pattern specification process GO:0007389 96 94 2,000 0,03049453 0,12517022 ! cofactor metabolic process GO:0051186 95 94 2,000 0,03049453 0,12489206 ! positive regulation of secretion GO:0051047 39 38 1,000 0,03081184 0,12591181 ! hexose catabolic process GO:0019320 38 38 1,000 0,03081184 0,12563324 ! axon guidance GO:0007411 39 38 1,000 0,03081184 0,1253559 ! steroid hormone receptor signaling pathway GO:0030518 38 38 1,000 0,03081184 0,12507979 ! hemostasis GO:0007599 42 39 1,000 0,03232891 0,13094985 ! nucleotide-excision repair GO:0006289 40 39 1,000 0,03232891 0,13066268 ! lymphocyte differentiation GO:0030098 39 39 1,000 0,03232891 0,13037676 ! limb development GO:0060173 39 39 1,000 0,03232891 0,1300921 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 1,000 0,03387498 0,13601652 ! myeloid cell differentiation GO:0030099 42 40 1,000 0,03387498 0,13572083 ! organelle localization GO:0051640 41 40 1,000 0,03387498 0,13542642 ! regulation of caspase activity GO:0043281 41 41 1,000 0,03544956 0,14141457 ! monosaccharide catabolic process GO:0046365 41 41 1,000 0,03544956 0,14110914 ! rRNA transcription GO:0009303 5 5 0,000 0,03582314 0,1422889 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,03582314 0,1419829 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,03582314 0,14167821 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,03582314 0,14137483 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! reproductive cellular process GO:0048610 5 5 0,000 0,03582314 0,14107275 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,03582314 0,14077196 ! metencephalon development GO:0022037 5 5 0,000 0,03582314 0,14047244 ! water transport GO:0006833 5 5 0,000 0,03582314 0,1401742 GO:0042044|fluid transport, ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,03582314 0,13987722 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,03582314 0,1395815 ! glycerol metabolic process GO:0006071 5 5 0,000 0,03582314 0,13928702 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,03582314 0,13899378 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,03582314 0,13870178 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,03582314 0,138411 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,03582314 0,13812144 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,03582314 0,13783309 ! filopodium assembly GO:0046847 7 5 0,000 0,03582314 0,13754593 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,03582314 0,13725997 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,03582314 0,1369752 ! GTP metabolic process GO:0046039 5 5 0,000 0,03582314 0,13669161 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,03582314 0,13640919 ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,03582314 0,13612793 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,03582314 0,13584784 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,03582314 0,13556889 ! social behavior GO:0035176 5 5 0,000 0,03582314 0,13529108 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,03582314 0,13501441 ! 2-oxoglutarate metabolic process GO:0006103 5 5 0,000 0,03582314 0,13473887 ! memory GO:0007613 5 5 0,000 0,03582314 0,13446446 ! dopamine receptor signaling pathway GO:0007212 5 5 0,000 0,03582314 0,13419115 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,03582314 0,13391896 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,03582314 0,13364787 ! response to lipid GO:0033993 5 5 0,000 0,03582314 0,13337787 ! erythrocyte maturation GO:0043249 5 5 0,000 0,03582314 0,13310897 ! hippocampus development GO:0021766 6 5 0,000 0,03582314 0,13284114 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,03582314 0,13257439 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,03582314 0,13230871 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,03582314 0,1320441 ! amyloid precursor protein catabolic process GO:0042987 5 5 0,000 0,03582314 0,13178053 ! mechanosensory behavior GO:0007638 5 5 0,000 0,03582314 0,13151802 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,03582314 0,13125656 ! response to interferon-gamma GO:0034341 5 5 0,000 0,03582314 0,13099613 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,03582314 0,13073673 ! pH reduction GO:0045851 5 5 0,000 0,03582314 0,13047836 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,03582314 0,130221 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,03582314 0,12996466 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,03582314 0,12970933 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,03582314 0,129455 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,03582314 0,12920166 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,03582314 0,12894931 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 0,000 0,03582314 0,12869795 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,03582314 0,12844756 ! adrenal gland development GO:0030325 5 5 0,000 0,03582314 0,12819815 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,03582314 0,12794971 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,03582314 0,12770222 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,03582314 0,12745569 ! astrocyte differentiation GO:0048708 5 5 0,000 0,03582314 0,12721011 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,03582314 0,12696548 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,03582314 0,12672178 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 0,000 0,03582314 0,12647902 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 0,000 0,03582314 0,12623719 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,03582314 0,12599627 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,03582314 0,12575628 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,03582314 0,1255172 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,03582314 0,12527903 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,03582314 0,12504176 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,03582314 0,12480538 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,03582314 0,1245699 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,03582314 0,12433531 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,03582314 0,12410159 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,03582314 0,12386876 ! response to ATP GO:0033198 5 5 0,000 0,03582314 0,12363679 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,03582314 0,1234057 ! regulation of appetite GO:0032098 5 5 0,000 0,03582314 0,12317546 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,03582314 0,12294609 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,03582314 0,12271756 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,03582314 0,12248988 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,03582314 0,12226305 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03582314 0,12203706 ! receptor clustering GO:0043113 5 5 0,000 0,03582314 0,1218119 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,03582314 0,12158757 ! fear response GO:0042596 5 5 0,000 0,03582314 0,12136406 ! actin cytoskeleton reorganization GO:0031532 5 5 0,000 0,03582314 0,12114137 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,03582314 0,1209195 ! retinol metabolic process GO:0042572 5 5 0,000 0,03582314 0,12069844 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,03582314 0,12047819 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,03582314 0,12025874 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,03582314 0,12004009 ! parturition GO:0007567 5 5 0,000 0,03582314 0,11982223 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03582314 0,11960516 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,03582314 0,11938887 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,03582314 0,11917337 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,03582314 0,11895864 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,03582314 0,11874469 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,03582314 0,1185315 ! response to UV-B GO:0010224 5 5 0,000 0,03582314 0,11831908 ! oligodendrocyte development GO:0014003 5 5 0,000 0,03582314 0,11810742 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,03582314 0,11789651 ! activated T cell proliferation GO:0050798 5 5 0,000 0,03582314 0,11768636 ! interaction with symbiont GO:0051702 5 5 0,000 0,03582314 0,11747695 ! cellular extravasation GO:0045123 5 5 0,000 0,03582314 0,11726829 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,03582314 0,11706037 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,03582314 0,11685318 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,03582314 0,11664673 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,03582314 0,116441 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,03582314 0,116236 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,03582314 0,11603172 ! response to amine stimulus GO:0014075 5 5 0,000 0,03582314 0,11582815 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,03582314 0,1156253 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,03582314 0,11542316 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,03582314 0,11522172 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,03582314 0,11502099 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,03582314 0,11482095 ! neuron recognition GO:0008038 5 5 0,000 0,03582314 0,11462161 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,03582314 0,11442296 ! decidualization GO:0046697 5 5 0,000 0,03582314 0,114225 ! hair follicle maturation GO:0048820 5 5 0,000 0,03582314 0,11402772 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,03582314 0,11383112 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,03582314 0,11363519 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,03582314 0,11343994 ! positive regulation of interleukin-6 production GO:0032755 5 5 0,000 0,03582314 0,11324537 ! postreplication repair GO:0006301 5 5 0,000 0,03582314 0,11305145 ! cellular pigmentation GO:0033059 5 5 0,000 0,03582314 0,1128582 ! histone methylation GO:0016571 5 5 0,000 0,03582314 0,11266561 ! DNA methylation GO:0006306 5 5 0,000 0,03582314 0,11247368 GO:0006305|DNA alkylation, ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03582314 0,11228239 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,03582314 0,11209176 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,03582314 0,11190178 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,03582314 0,11171243 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,03582314 0,11152373 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,03582314 0,11133566 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,03582314 0,11114823 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,03582314 0,11096142 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,03582314 0,11077525 ! sterol catabolic process GO:0016127 5 5 0,000 0,03582314 0,11058969 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,03582314 0,11040476 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,03582314 0,11022045 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,03582314 0,11003675 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,03582314 0,10985366 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! zymogen activation GO:0031638 5 5 0,000 0,03582314 0,10967118 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,03582314 0,1094893 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,03582314 0,10930803 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 0,03582314 0,10912735 ! peptidyl-histidine modification GO:0018202 5 5 0,000 0,03582314 0,10894727 ! nucleosome positioning GO:0016584 5 5 0,000 0,03582314 0,10876779 ! regulation of isotype switching GO:0045191 5 5 0,000 0,03582314 0,10858889 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,03582314 0,10841059 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,03582314 0,10823287 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,03582314 0,10805572 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,03582314 0,10787916 ! NADPH regeneration GO:0006740 5 5 0,000 0,03582314 0,10770318 GO:0006098|pentose-phosphate shunt, ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,03582314 0,10752777 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 0,000 0,03582314 0,10735292 GO:0002688|regulation of leukocyte chemotaxis, ! musculoskeletal movement GO:0050881 5 5 0,000 0,03582314 0,10717865 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,03582314 0,10700494 ! sarcomere organization GO:0045214 5 5 0,000 0,03582314 0,10683179 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,03582314 0,1066592 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,03582314 0,10648717 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,03582314 0,1063157 GO:0046325|negative regulation of glucose import, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 0,000 0,03582314 0,10614477 GO:0045622|regulation of T-helper cell differentiation, ! oocyte differentiation GO:0009994 5 5 0,000 0,03582314 0,10597439 GO:0048599|oocyte development, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,03582314 0,10580456 ! regulation of protein homodimerization activity GO:0043496 6 5 0,000 0,03582314 0,10563528 ! spleen development GO:0048536 5 5 0,000 0,03582314 0,10546653 ! male genitalia development GO:0030539 5 5 0,000 0,03582314 0,10529832 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,03582314 0,10513065 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,03582314 0,10496351 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,03582314 0,1047969 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,03582314 0,10463082 ! positive regulation of viral reproduction GO:0048524 5 5 0,000 0,03582314 0,10446527 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,03582314 0,10430023 ! myeloid cell homeostasis GO:0002262 5 5 0,000 0,03582314 0,10413572 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,03582314 0,10397173 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,03582314 0,10380825 ! ATP catabolic process GO:0006200 5 5 0,000 0,03582314 0,10364529 ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,03582314 0,10348283 ! blastocyst formation GO:0001825 5 5 0,000 0,03582314 0,10332089 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,03582314 0,10315945 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,03582314 0,10299851 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,03582314 0,10283808 ! activation of innate immune response GO:0002218 5 5 0,000 0,03582314 0,10267815 GO:0002758|innate immune response-activating signal transduction, ! catecholamine transport GO:0051937 5 5 0,000 0,03582314 0,10251871 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,03582314 0,10235976 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,03582314 0,10220131 ! muscle adaptation GO:0043500 5 5 0,000 0,03582314 0,10204335 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,03582314 0,10188588 ! embryonic heart tube development GO:0035050 5 5 0,000 0,03582314 0,10172889 ! cardiac cell differentiation GO:0035051 6 5 0,000 0,03582314 0,10157238 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,03582314 0,10141636 ! defense response to fungus GO:0050832 5 5 0,000 0,03582314 0,10126081 ! lysogeny GO:0030069 5 5 0,000 0,03582314 0,10110574 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,03582314 0,10095114 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,03582314 0,10079702 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,03582314 0,10064337 ! response to nicotine GO:0035094 5 5 0,000 0,03582314 0,10049018 ! establishment of cell polarity GO:0030010 5 5 0,000 0,03582314 0,10033746 ! mitochondrion localization GO:0051646 5 5 0,000 0,03582314 0,1001852 ! nucleus localization GO:0051647 5 5 0,000 0,03582314 0,10003341 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,03582314 0,09988207 ! regulation of endopeptidase activity GO:0052548 42 42 1,000 0,03705218 0,10315281 ! forebrain development GO:0030900 43 42 1,000 0,03705218 0,10299722 ! reproductive structure development GO:0048608 43 43 1,000 0,03868236 0,10736684 ! alcohol catabolic process GO:0046164 43 43 1,000 0,03868236 0,10720539 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 1,000 0,04033964 0,11163055 ! negative regulation of organelle organization GO:0010639 45 44 1,000 0,04033964 0,11146319 ! homophilic cell adhesion GO:0007156 45 45 1,000 0,04202355 0,11594221 ! phosphoinositide-mediated signaling GO:0048015 45 45 1,000 0,04202355 0,11576891 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 1,000 0,04202355 0,11559612 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 0,000 0,04283534 0,11765354 ! axon extension GO:0048675 7 6 0,000 0,04283534 0,11747846 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,04283534 0,1173039 ! tRNA modification GO:0006400 6 6 0,000 0,04283534 0,11712986 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,04283534 0,11695633 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,04283534 0,11678332 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,04283534 0,11661082 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,04283534 0,11643883 ! regulation of S phase GO:0033261 6 6 0,000 0,04283534 0,11626734 ! myotube differentiation GO:0014902 6 6 0,000 0,04283534 0,11609636 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,04283534 0,11592588 ! bone remodeling GO:0046849 6 6 0,000 0,04283534 0,1157559 ! N-glycan processing GO:0006491 6 6 0,000 0,04283534 0,11558642 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,04283534 0,11541743 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,04283534 0,11524894 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,04283534 0,11508094 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,04283534 0,11491343 ! RNA methylation GO:0001510 6 6 0,000 0,04283534 0,1147464 ! cartilage condensation GO:0001502 7 6 0,000 0,04283534 0,11457986 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,04283534 0,1144138 ! succinate metabolic process GO:0006105 7 6 0,000 0,04283534 0,11424823 ! artery development GO:0060840 6 6 0,000 0,04283534 0,11408313 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,04283534 0,1139185 ! bile acid metabolic process GO:0008206 6 6 0,000 0,04283534 0,11375436 ! androgen metabolic process GO:0008209 6 6 0,000 0,04283534 0,11359068 ! estrogen metabolic process GO:0008210 6 6 0,000 0,04283534 0,11342748 ! limbic system development GO:0021761 7 6 0,000 0,04283534 0,11326474 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,04283534 0,11310247 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 0,000 0,04283534 0,11294066 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,04283534 0,11277932 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,04283534 0,11261844 ! pathogenesis GO:0009405 6 6 0,000 0,04283534 0,11245801 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,04283534 0,11229804 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,04283534 0,11213853 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,04283534 0,11197947 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! regulation of chemokine biosynthetic process GO:0045073 6 6 0,000 0,04283534 0,11182086 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,04283534 0,11166269 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,04283534 0,11150498 ! arginine metabolic process GO:0006525 6 6 0,000 0,04283534 0,11134771 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,04283534 0,11119088 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,04283534 0,11103449 ! glutamate catabolic process GO:0006538 7 6 0,000 0,04283534 0,11087854 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,04283534 0,11072303 GO:0010833|telomere maintenance via telomere lengthening, ! L-phenylalanine metabolic process GO:0006558 6 6 0,000 0,04283534 0,11056796 GO:0006559|L-phenylalanine catabolic process, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,04283534 0,11041332 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 0,04283534 0,11025911 ! V(D)J recombination GO:0033151 6 6 0,000 0,04283534 0,11010533 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,04283534 0,10995198 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,04283534 0,10979906 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,04283534 0,10964656 ! regulation of heart rate GO:0002027 6 6 0,000 0,04283534 0,10949449 ! lipid digestion GO:0044241 6 6 0,000 0,04283534 0,10934283 ! asymmetric protein localization GO:0008105 6 6 0,000 0,04283534 0,1091916 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,04283534 0,10904078 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,04283534 0,10889038 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,04283534 0,10874039 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,04283534 0,10859082 ! ruffle organization GO:0031529 6 6 0,000 0,04283534 0,10844165 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,04283534 0,1082929 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,04283534 0,10814455 ! neutral amino acid transport GO:0015804 6 6 0,000 0,04283534 0,10799661 ! L-amino acid transport GO:0015807 6 6 0,000 0,04283534 0,10784908 ! bone mineralization GO:0030282 6 6 0,000 0,04283534 0,10770194 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,04283534 0,10755521 ! negative regulation of ossification GO:0030279 6 6 0,000 0,04283534 0,10740888 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,04283534 0,10726294 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,04283534 0,1071174 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,04283534 0,10697225 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,04283534 0,1068275 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,04283534 0,10668314 ! regulation of organ growth GO:0046620 6 6 0,000 0,04283534 0,10653917 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,04283534 0,10639558 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,04283534 0,10625239 ! response to dsRNA GO:0043331 6 6 0,000 0,04283534 0,10610958 ! DNA unwinding during replication GO:0006268 6 6 0,000 0,04283534 0,10596715 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,04283534 0,1058251 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,04283534 0,10568343 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,04283534 0,10554214 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,04283534 0,10540123 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,04283534 0,1052607 ! multicellular organismal aging GO:0010259 6 6 0,000 0,04283534 0,10512054 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,04283534 0,10498075 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,04283534 0,10484133 ! erythrocyte development GO:0048821 6 6 0,000 0,04283534 0,10470229 ! renal water homeostasis GO:0003091 6 6 0,000 0,04283534 0,10456361 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 0,000 0,04283534 0,1044253 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,04283534 0,10428735 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,04283534 0,10414977 ! ribosome assembly GO:0042255 6 6 0,000 0,04283534 0,10401255 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,04283534 0,10387569 ! diencephalon development GO:0021536 6 6 0,000 0,04283534 0,10373919 ! fucose catabolic process GO:0019317 6 6 0,000 0,04283534 0,10360305 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,04283534 0,10346727 GO:0006809|nitric oxide biosynthetic process, ! protein sumoylation GO:0016925 6 6 0,000 0,04283534 0,10333184 ! regulation of lipid transport GO:0032368 6 6 0,000 0,04283534 0,10319676 ! regulation of cell division GO:0051302 6 6 0,000 0,04283534 0,10306204 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,04283534 0,10292767 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,04283534 0,10279365 ! regulation of T-helper 2 type immune response GO:0002828 6 6 0,000 0,04283534 0,10265998 ! salivary gland morphogenesis GO:0007435 6 6 0,000 0,04283534 0,10252665 ! neuroblast proliferation GO:0007405 6 6 0,000 0,04283534 0,10239368 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,04283534 0,10226104 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,04283534 0,10212875 ! regulation of glucose transport GO:0010827 6 6 0,000 0,04283534 0,1019968 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,04283534 0,10186519 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,04283534 0,10173392 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,04283534 0,10160299 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 0,04283534 0,1014724 ! thymus development GO:0048538 6 6 0,000 0,04283534 0,10134214 ! lymph node development GO:0048535 6 6 0,000 0,04283534 0,10121221 ! organic cation transport GO:0015695 6 6 0,000 0,04283534 0,10108262 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,04283534 0,10095336 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,04283534 0,10082442 ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,04283534 0,10069582 ! sperm-egg recognition GO:0035036 7 6 0,000 0,04283534 0,10056755 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,04283534 0,1004396 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,04283534 0,10031197 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,04283534 0,10018467 ! alditol metabolic process GO:0019400 6 6 0,000 0,04283534 0,1000577 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,04283534 0,09993104 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,04283534 0,09980471 ! maternal placenta development GO:0001893 6 6 0,000 0,04283534 0,09967869 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,04283534 0,09955299 ! tube morphogenesis GO:0035239 47 46 1,000 0,04373364 0,10151271 ! regulation of peptidase activity GO:0052547 46 46 1,000 0,04373364 0,10138502 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 1,000 0,04373364 0,10125765 ! positive regulation of ligase activity GO:0051351 47 46 1,000 0,04373364 0,10113061 ! sex differentiation GO:0007548 47 47 1,000 0,04546945 0,10501278 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 1,000 0,04723054 0,10894353 ! regulation of cell cycle process GO:0010564 50 48 1,000 0,04723054 0,10880735 ! leukocyte differentiation GO:0002521 50 49 1,000 0,04901646 0,1127807 ! ossification GO:0001503 50 49 1,000 0,04901646 0,11264007 GO:0060348|bone development, ! response to bacterium GO:0009617 50 49 1,000 0,04901646 0,1124998 ! regulation of ligase activity GO:0051340 50 49 1,000 0,04901646 0,11235988 ! respiratory burst GO:0045730 7 7 0,000 0,04979755 0,11400854 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 0,000 0,04979755 0,11386709 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 0,000 0,04979755 0,11372599 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,04979755 0,11358524 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,04979755 0,11344484 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,04979755 0,11330479 ! double-strand break repair via homologous recombination GO:0000724 7 7 0,000 0,04979755 0,11316508 GO:0000725|recombinational repair, ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,04979755 0,11302571 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,04979755 0,11288669 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,04979755 0,11274801 GO:0043241|protein complex disassembly, ! hair follicle morphogenesis GO:0031069 7 7 0,000 0,04979755 0,11260967 ! gene silencing by RNA GO:0031047 7 7 0,000 0,04979755 0,11247166 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,04979755 0,112334 ! oxaloacetate metabolic process GO:0006107 7 7 0,000 0,04979755 0,11219667 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,04979755 0,11205968 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,04979755 0,11192302 ! axis specification GO:0009798 7 7 0,000 0,04979755 0,1117867 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,04979755 0,1116507 ! visual behavior GO:0007632 7 7 0,000 0,04979755 0,11151504 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,04979755 0,11137971 ! amyloid precursor protein metabolic process GO:0042982 7 7 0,000 0,04979755 0,1112447 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,04979755 0,11111002 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,04979755 0,11097567 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,04979755 0,11084164 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,04979755 0,11070793 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,04979755 0,11057455 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,04979755 0,11044149 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,04979755 0,11030875 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,04979755 0,11017632 ! protein targeting to ER GO:0045047 8 7 0,000 0,04979755 0,11004422 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,04979755 0,10991243 ! endoderm development GO:0007492 7 7 0,000 0,04979755 0,10978095 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,04979755 0,10964979 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,04979755 0,10951895 GO:0006688|glycosphingolipid biosynthetic process, ! regulation of mRNA processing GO:0050684 7 7 0,000 0,04979755 0,10938841 ! response to hexose stimulus GO:0009746 7 7 0,000 0,04979755 0,10925819 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! membrane protein ectodomain proteolysis GO:0006509 7 7 0,000 0,04979755 0,10912827 GO:0033619|membrane protein proteolysis, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,04979755 0,10899867 ! regulation of skeletal muscle fiber development GO:0048742 7 7 0,000 0,04979755 0,10886937 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,04979755 0,10874038 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,04979755 0,10861169 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,04979755 0,10848331 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,04979755 0,10835523 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,04979755 0,10822745 ! UV protection GO:0009650 7 7 0,000 0,04979755 0,10809997 ! DNA integration GO:0015074 7 7 0,000 0,04979755 0,1079728 ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,04979755 0,10784592 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,04979755 0,10771934 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,04979755 0,10759306 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,04979755 0,10746707 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,04979755 0,10734138 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,04979755 0,10721598 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,04979755 0,10709087 GO:0019827|stem cell maintenance, ! alpha-beta T cell differentiation GO:0046632 7 7 0,000 0,04979755 0,10696606 ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,04979755 0,10684153 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,04979755 0,1067173 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,04979755 0,10659335 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,04979755 0,1064697 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,04979755 0,10634632 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,04979755 0,10622324 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,04979755 0,10610044 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,04979755 0,10597792 ! induction of an organ GO:0001759 7 7 0,000 0,04979755 0,10585568 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,04979755 0,10573373 GO:0002263|cell activation during immune response, ! response to estradiol stimulus GO:0032355 7 7 0,000 0,04979755 0,10561206 ! autonomic nervous system development GO:0048483 7 7 0,000 0,04979755 0,10549066 ! intracellular lipid transport GO:0032365 7 7 0,000 0,04979755 0,10536955 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,04979755 0,10524871 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,04979755 0,10512815 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,04979755 0,10500787 ! natural killer cell activation GO:0030101 7 7 0,000 0,04979755 0,10488786 ! NADP metabolic process GO:0006739 7 7 0,000 0,04979755 0,10476812 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,04979755 0,10464866 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,04979755 0,10452947 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,04979755 0,10441055 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,04979755 0,10429191 ! positive regulation of acute inflammatory response GO:0002675 7 7 0,000 0,04979755 0,10417353 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,04979755 0,10405542 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,04979755 0,10393757 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,04979755 0,10382 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,04979755 0,10370269 ! cell-cell recognition GO:0009988 8 7 0,000 0,04979755 0,10358564 ! hormone catabolic process GO:0042447 7 7 0,000 0,04979755 0,10346886 ! dopamine metabolic process GO:0042417 7 7 0,000 0,04979755 0,10335234 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,04979755 0,10323608 ! oxygen transport GO:0015671 7 7 0,000 0,04979755 0,10312009 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,04979755 0,10300435 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,04979755 0,10288888 ! regulation of axon extension GO:0030516 7 7 0,000 0,04979755 0,10277366 ! cell killing GO:0001906 7 7 0,000 0,04979755 0,1026587 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,04979755 0,102544 ! adult feeding behavior GO:0008343 7 7 0,000 0,04979755 0,10242955 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,04979755 0,10231536 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,04979755 0,10220142 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,04979755 0,10208774 ! response to cold GO:0009409 7 7 0,000 0,04979755 0,10197431 ! regulation of defense response GO:0031347 50 50 1,000 0,05082678 0,10396643 ! negative regulation of transport GO:0051051 51 50 1,000 0,05082678 0,10385117 ! T cell activation GO:0042110 51 50 1,000 0,05082678 0,10373617 ! regulation of neurogenesis GO:0050767 51 50 1,000 0,05082678 0,10362141 ! anatomical structure homeostasis GO:0060249 51 50 1,000 0,05082678 0,10350691 ! protein modification by small protein conjugation GO:0032446 52 51 1,000 0,05266106 0,10712399 ! regulation of body fluid levels GO:0050878 55 52 1,000 0,05451888 0,11078092 ! carbohydrate catabolic process GO:0016052 53 53 1,000 0,05639981 0,1144767 ! regulation of T cell activation GO:0050863 53 53 1,000 0,05639981 0,11435077 ! regulation of skeletal muscle tissue development GO:0048641 8 8 0,000 0,05671012 0,11485357 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,05671012 0,1147275 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,05671012 0,1146017 ! positive regulation of translation GO:0045727 8 8 0,000 0,05671012 0,11447618 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,05671012 0,11435093 ! superoxide anion generation GO:0042554 8 8 0,000 0,05671012 0,11422596 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,05671012 0,11410126 ! cGMP metabolic process GO:0046068 8 8 0,000 0,05671012 0,11397683 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,05671012 0,11385267 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,05671012 0,11372878 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,05671012 0,11360516 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,05671012 0,11348182 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,05671012 0,11335873 ! zinc ion transport GO:0006829 8 8 0,000 0,05671012 0,11323592 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,05671012 0,11311337 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,05671012 0,11299108 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,05671012 0,11286906 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,05671012 0,1127473 ! lipid localization GO:0010876 8 8 0,000 0,05671012 0,11262581 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,05671012 0,11250458 ! response to cAMP GO:0051591 8 8 0,000 0,05671012 0,1123836 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,05671012 0,11226289 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,05671012 0,11214244 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,05671012 0,11202224 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,05671012 0,1119023 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,05671012 0,11178262 GO:0032107|regulation of response to nutrient levels, ! sensory perception of taste GO:0050909 8 8 0,000 0,05671012 0,1116632 ! organelle fusion GO:0048284 8 8 0,000 0,05671012 0,11154403 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,05671012 0,11142511 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! T cell selection GO:0045058 8 8 0,000 0,05671012 0,11130644 ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,05671012 0,11118803 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,05671012 0,11106987 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,05671012 0,11095197 ! sperm motility GO:0030317 8 8 0,000 0,05671012 0,11083431 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,05671012 0,1107169 ! DNA duplex unwinding GO:0032508 8 8 0,000 0,05671012 0,11059974 GO:0032392|DNA geometric change, ! glycine metabolic process GO:0006544 8 8 0,000 0,05671012 0,11048282 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,05671012 0,11036616 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,05671012 0,11024974 GO:0031114|regulation of microtubule depolymerization, ! phosphagen metabolic process GO:0006599 8 8 0,000 0,05671012 0,11013356 GO:0006600|creatine metabolic process, ! polyamine metabolic process GO:0006595 8 8 0,000 0,05671012 0,11001763 ! Golgi organization GO:0007030 8 8 0,000 0,05671012 0,10990195 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,05671012 0,1097865 ! fructose metabolic process GO:0006000 8 8 0,000 0,05671012 0,1096713 ! mannose metabolic process GO:0006013 9 8 0,000 0,05671012 0,10955634 ! NAD metabolic process GO:0019674 8 8 0,000 0,05671012 0,10944162 ! negative regulation of mitotic cell cycle GO:0045930 9 8 0,000 0,05671012 0,10932715 ! plasma membrane fusion GO:0045026 8 8 0,000 0,05671012 0,10921291 ! response to fungus GO:0009620 8 8 0,000 0,05671012 0,10909891 ! stem cell differentiation GO:0048863 8 8 0,000 0,05671012 0,10898514 ! alpha-beta T cell activation GO:0046631 8 8 0,000 0,05671012 0,10887162 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,05671012 0,10875833 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,05671012 0,10864527 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,05671012 0,10853245 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,05671012 0,10841987 ! regulation of vasodilation GO:0042312 8 8 0,000 0,05671012 0,10830751 ! vasoconstriction GO:0042310 8 8 0,000 0,05671012 0,1081954 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,05671012 0,10808351 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,05671012 0,10797185 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,05671012 0,10786042 ! sensory perception of pain GO:0019233 8 8 0,000 0,05671012 0,10774923 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,05671012 0,10763826 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,05671012 0,10752752 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,05671012 0,10741701 ! chromatin silencing GO:0006342 8 8 0,000 0,05671012 0,10730673 ! tissue regeneration GO:0042246 8 8 0,000 0,05671012 0,10719667 ! salivary gland development GO:0007431 8 8 0,000 0,05671012 0,10708684 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,05671012 0,10697723 ! T cell homeostasis GO:0043029 8 8 0,000 0,05671012 0,10686784 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,05671012 0,10675868 ! water homeostasis GO:0030104 8 8 0,000 0,05671012 0,10664975 ! cofactor transport GO:0051181 8 8 0,000 0,05671012 0,10654103 ! regulation of acute inflammatory response GO:0002673 8 8 0,000 0,05671012 0,10643254 ! acid secretion GO:0046717 8 8 0,000 0,05671012 0,10632426 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,05671012 0,10621621 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,05671012 0,10610838 ! regulation of immunoglobulin production GO:0002637 8 8 0,000 0,05671012 0,10600076 ! branched chain family amino acid metabolic process GO:0009081 8 8 0,000 0,05671012 0,10589337 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,05671012 0,10578619 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,05671012 0,10567922 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,05671012 0,10557248 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,05671012 0,10546595 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,05671012 0,10535963 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,05671012 0,10525353 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,05671012 0,10514764 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,05671012 0,10504196 ! developmental induction GO:0031128 8 8 0,000 0,05671012 0,1049365 GO:0045168|cell-cell signaling involved in cell fate specification, ! peptide hormone secretion GO:0030072 8 8 0,000 0,05671012 0,10483125 ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,05671012 0,1047262 ! actin filament polymerization GO:0030041 9 8 0,000 0,05671012 0,10462137 ! cytoplasmic sequestering of protein GO:0051220 8 8 0,000 0,05671012 0,10451675 ! peptide hormone processing GO:0016486 8 8 0,000 0,05671012 0,10441234 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,05671012 0,10430814 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,05671012 0,10420414 ! protein amino acid dephosphorylation GO:0006470 55 54 1,000 0,05830343 0,10702512 ! hormone metabolic process GO:0042445 55 54 1,000 0,05830343 0,10691863 ! sulfur metabolic process GO:0006790 55 54 1,000 0,05830343 0,10681235 ! negative regulation of multicellular organismal process GO:0051241 55 54 1,000 0,05830343 0,10670628 ! regulation of cell adhesion GO:0030155 56 55 1,000 0,06022933 0,11012168 ! extracellular structure organization GO:0043062 56 56 1,000 0,0621771 0,11357026 ! regulation of nervous system development GO:0051960 57 56 1,000 0,0621771 0,11345781 ! lactation GO:0007595 10 9 0,000 0,06357341 0,11589098 ! embryonic pattern specification GO:0009880 10 9 0,000 0,06357341 0,11577647 ! positive regulation of cell size GO:0045793 9 9 0,000 0,06357341 0,11566218 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,06357341 0,11554811 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,06357341 0,11543427 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,06357341 0,11532066 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,06357341 0,11520726 ! viral genome replication GO:0019079 9 9 0,000 0,06357341 0,11509409 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,06357341 0,11498114 ! copper ion transport GO:0006825 9 9 0,000 0,06357341 0,11486842 ! lipid phosphorylation GO:0046834 9 9 0,000 0,06357341 0,11475591 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,06357341 0,11464363 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,06357341 0,11453156 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,06357341 0,11441971 ! RNA polyadenylation GO:0043631 9 9 0,000 0,06357341 0,11430808 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,06357341 0,11419667 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,06357341 0,11408548 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,06357341 0,1139745 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 0,000 0,06357341 0,11386374 ! phospholipid efflux GO:0033700 9 9 0,000 0,06357341 0,11375319 ! response to alkaloid GO:0043279 10 9 0,000 0,06357341 0,11364286 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,06357341 0,11353274 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,06357341 0,11342283 GO:0042107|cytokine metabolic process, ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,06357341 0,11331314 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,06357341 0,11320366 ! response to ethanol GO:0045471 9 9 0,000 0,06357341 0,11309439 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,06357341 0,11298533 ! activation of pro-apoptotic gene products GO:0008633 9 9 0,000 0,06357341 0,11287648 ! methionine metabolic process GO:0006555 9 9 0,000 0,06357341 0,11276784 ! glutamine metabolic process GO:0006541 9 9 0,000 0,06357341 0,11265941 ! cerebral cortex development GO:0021987 9 9 0,000 0,06357341 0,11255119 ! response to osmotic stress GO:0006970 9 9 0,000 0,06357341 0,11244317 ! pigmentation during development GO:0048066 9 9 0,000 0,06357341 0,11233537 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,06357341 0,11222776 ! central nervous system neuron development GO:0021954 10 9 0,000 0,06357341 0,11212037 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,06357341 0,11201318 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,06357341 0,11190619 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,06357341 0,11179941 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,06357341 0,11169284 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,06357341 0,11158646 ! L-glutamate transport GO:0015813 9 9 0,000 0,06357341 0,11148029 GO:0015800|acidic amino acid transport, ! peptide secretion GO:0002790 9 9 0,000 0,06357341 0,11137432 ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,06357341 0,11126855 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,06357341 0,11116298 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 0,000 0,06357341 0,11105762 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 0,000 0,06357341 0,11095245 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,06357341 0,11084748 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,06357341 0,11074271 ! prostaglandin metabolic process GO:0006693 9 9 0,000 0,06357341 0,11063814 GO:0006692|prostanoid metabolic process, ! T cell differentiation in the thymus GO:0033077 9 9 0,000 0,06357341 0,11053376 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,06357341 0,11042958 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,06357341 0,1103256 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,06357341 0,11022181 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,06357341 0,11011822 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,06357341 0,11001482 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,06357341 0,10991162 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,06357341 0,10980861 ! collagen catabolic process GO:0030574 9 9 0,000 0,06357341 0,10970579 ! aromatic amino acid family catabolic process GO:0009074 9 9 0,000 0,06357341 0,10960317 ! purine base metabolic process GO:0006144 9 9 0,000 0,06357341 0,10950073 ! gas transport GO:0015669 9 9 0,000 0,06357341 0,10939849 ! cholesterol efflux GO:0033344 9 9 0,000 0,06357341 0,10929644 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,06357341 0,10919458 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,06357341 0,10909291 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,06357341 0,10899143 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,06357341 0,10889014 ! defense response to virus GO:0051607 9 9 0,000 0,06357341 0,10878903 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,06357341 0,10868811 ! actin filament-based movement GO:0030048 9 9 0,000 0,06357341 0,10858738 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,06357341 0,10848684 ! dephosphorylation GO:0016311 60 59 1,000 0,06814759 0,11618503 ! regulation of cell development GO:0060284 60 59 1,000 0,06814759 0,11607765 ! protein polymerization GO:0051258 65 60 1,000 0,07017883 0,11942714 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,07038775 0,11967215 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,07038775 0,11956186 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 0,000 0,07038775 0,11945176 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,07038775 0,11934187 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,07038775 0,11923218 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,07038775 0,11912269 ! neuron maturation GO:0042551 10 10 0,000 0,07038775 0,11901341 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,07038775 0,11890432 ! positive regulation of anti-apoptosis GO:0045768 10 10 0,000 0,07038775 0,11879543 GO:0045767|regulation of anti-apoptosis, ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,07038775 0,11868675 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,07038775 0,11857826 ! reciprocal meiotic recombination GO:0007131 10 10 0,000 0,07038775 0,11846997 ! hormone secretion GO:0046879 10 10 0,000 0,07038775 0,11836187 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,07038775 0,11825398 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,07038775 0,11814628 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 0,000 0,07038775 0,11803878 ! inositol metabolic process GO:0006020 10 10 0,000 0,07038775 0,11793147 ! cAMP metabolic process GO:0046058 10 10 0,000 0,07038775 0,11782435 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,07038775 0,11771744 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,07038775 0,11761071 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,07038775 0,11750418 ! glial cell development GO:0021782 10 10 0,000 0,07038775 0,11739784 ! phototransduction GO:0007602 11 10 0,000 0,07038775 0,11729169 ! calcium-independent cell-cell adhesion GO:0016338 10 10 0,000 0,07038775 0,11718574 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,07038775 0,11707998 ! fat cell differentiation GO:0045444 10 10 0,000 0,07038775 0,1169744 ! myoblast differentiation GO:0045445 10 10 0,000 0,07038775 0,11686902 ! centrosome cycle GO:0007098 10 10 0,000 0,07038775 0,11676383 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,07038775 0,11665883 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,07038775 0,11655401 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,07038775 0,11644938 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,07038775 0,11634495 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,07038775 0,11624069 ! epidermis morphogenesis GO:0048730 10 10 0,000 0,07038775 0,11613663 ! protein polyubiquitination GO:0000209 10 10 0,000 0,07038775 0,11603275 ! glutamate metabolic process GO:0006536 11 10 0,000 0,07038775 0,11592906 ! plasma membrane organization GO:0007009 10 10 0,000 0,07038775 0,11582555 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,07038775 0,11572223 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,07038775 0,11561909 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,07038775 0,11551613 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,07038775 0,11541336 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,07038775 0,11531077 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,07038775 0,11520836 ! exocrine system development GO:0035272 10 10 0,000 0,07038775 0,11510614 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,07038775 0,11500409 ! embryo implantation GO:0007566 11 10 0,000 0,07038775 0,11490223 ! regulation of protein binding GO:0043393 11 10 0,000 0,07038775 0,11480054 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,07038775 0,11469904 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,07038775 0,11459772 GO:0070585|protein localization in mitochondrion, ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 0,000 0,07038775 0,11449657 ! protein export from nucleus GO:0006611 10 10 0,000 0,07038775 0,1143956 ! negative regulation of immune response GO:0050777 10 10 0,000 0,07038775 0,11429481 ! cytolysis GO:0019835 10 10 0,000 0,07038775 0,1141942 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,07038775 0,11409377 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,07038775 0,11399351 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,07038775 0,11389343 ! histone deacetylation GO:0016575 10 10 0,000 0,07038775 0,11379352 ! mRNA splice site selection GO:0006376 11 10 0,000 0,07038775 0,11369379 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,07038775 0,11359423 ! gland morphogenesis GO:0022612 10 10 0,000 0,07038775 0,11349485 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,07038775 0,11339564 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,07038775 0,11329661 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,07038775 0,11319774 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,07038775 0,11309905 ! regulation of epidermis development GO:0045682 10 10 0,000 0,07038775 0,11300054 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,07038775 0,11290219 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,07038775 0,11280401 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,07038775 0,11270601 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,07038775 0,11260817 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,07038775 0,11251051 ! lymphocyte homeostasis GO:0002260 10 10 0,000 0,07038775 0,11241301 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,07038775 0,11231568 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,07038775 0,11221852 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,07038775 0,11212153 ! protein stabilization GO:0050821 10 10 0,000 0,07038775 0,11202471 ! cellular respiration GO:0045333 62 61 1,000 0,07222997 0,11485749 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 1,000 0,07222997 0,11475847 ! morphogenesis of an epithelium GO:0002009 63 62 1,000 0,0743006 0,11794661 GO:0060429|epithelium development, ! regulation of lymphocyte activation GO:0051249 62 62 1,000 0,0743006 0,1178451 ! regulation of secretion GO:0051046 65 63 1,000 0,07639037 0,12105542 ! negative regulation of cellular component organization GO:0051129 65 63 1,000 0,07639037 0,12095142 ! glucose metabolic process GO:0006006 63 63 1,000 0,07639037 0,1208476 ! protein secretion GO:0009306 11 11 0,000 0,07715348 0,12195014 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,07715348 0,12184564 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 0,000 0,07715348 0,12174132 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,07715348 0,12163718 ! negative regulation of defense response GO:0031348 11 11 0,000 0,07715348 0,12153322 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,07715348 0,12142943 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,07715348 0,12132583 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! phosphatidylinositol metabolic process GO:0046488 11 11 0,000 0,07715348 0,12122239 ! skin development GO:0043588 11 11 0,000 0,07715348 0,12111914 ! signal complex assembly GO:0007172 11 11 0,000 0,07715348 0,12101606 ! endothelial cell migration GO:0043542 11 11 0,000 0,07715348 0,12091315 ! peroxisomal transport GO:0043574 11 11 0,000 0,07715348 0,12081042 ! protein amino acid methylation GO:0006479 11 11 0,000 0,07715348 0,12070787 GO:0008213|protein amino acid alkylation, ! heart contraction GO:0060047 11 11 0,000 0,07715348 0,12060549 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,07715348 0,12050328 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,07715348 0,12040124 ! T cell proliferation GO:0042098 11 11 0,000 0,07715348 0,12029938 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,07715348 0,12019769 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,07715348 0,12009617 ! regulation of viral genome replication GO:0045069 11 11 0,000 0,07715348 0,11999482 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,07715348 0,11989365 ! smooth muscle contraction GO:0006939 11 11 0,000 0,07715348 0,11979264 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,07715348 0,11969181 ! digestive system process GO:0022600 11 11 0,000 0,07715348 0,11959114 ! mitotic spindle organization GO:0007052 11 11 0,000 0,07715348 0,11949064 ! fucose metabolic process GO:0006004 11 11 0,000 0,07715348 0,11939032 ! membrane budding GO:0006900 11 11 0,000 0,07715348 0,11929016 ! apoptotic nuclear changes GO:0030262 11 11 0,000 0,07715348 0,11919017 ! monoamine transport GO:0015844 11 11 0,000 0,07715348 0,11909034 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,07715348 0,11899068 ! body fluid secretion GO:0007589 11 11 0,000 0,07715348 0,11889119 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 0,000 0,07715348 0,11879187 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 0,000 0,07715348 0,11869271 GO:0060415|muscle tissue morphogenesis, ! membrane depolarization GO:0051899 11 11 0,000 0,07715348 0,11859372 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,07715348 0,11849489 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,07715348 0,11839623 ! oogenesis GO:0048477 11 11 0,000 0,07715348 0,11829773 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,07715348 0,11819939 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,07715348 0,11810122 ! vitamin transport GO:0051180 11 11 0,000 0,07715348 0,11800321 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,07715348 0,11790536 ! hindbrain development GO:0030902 11 11 0,000 0,07715348 0,11780768 ! steroid catabolic process GO:0006706 11 11 0,000 0,07715348 0,11771016 ! endocrine process GO:0050886 11 11 0,000 0,07715348 0,11761279 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! aromatic amino acid family metabolic process GO:0009072 11 11 0,000 0,07715348 0,11751559 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,07715348 0,11741855 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,07715348 0,11732167 ! glycerolipid metabolic process GO:0046486 65 64 1,000 0,07849889 0,11926913 ! angiogenesis GO:0001525 65 64 1,000 0,07849889 0,11917088 ! regulation of cytoskeleton organization GO:0051493 66 64 1,000 0,07849889 0,1190728 ! positive regulation of cellular component organization GO:0051130 65 65 1,000 0,08062579 0,12219847 ! regulation of hormone levels GO:0010817 66 65 1,000 0,08062579 0,12209806 ! DNA packaging GO:0006323 66 66 1,000 0,08277071 0,12524337 ! polysaccharide metabolic process GO:0005976 69 66 1,000 0,08277071 0,12514063 ! positive regulation of protein catabolic process GO:0045732 12 12 0,000 0,08387096 0,12670014 ! translational initiation GO:0006413 12 12 0,000 0,08387096 0,12659637 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 0,000 0,08387096 0,12649278 ! initiation of viral infection GO:0019059 12 12 0,000 0,08387096 0,12638935 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,08387096 0,12628609 ! iron ion transport GO:0006826 13 12 0,000 0,08387096 0,126183 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,08387096 0,12608007 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,08387096 0,12597732 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,08387096 0,12587473 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,08387096 0,12577231 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,08387096 0,12567006 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,08387096 0,12556797 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,08387096 0,12546605 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,08387096 0,12536429 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,08387096 0,1252627 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,08387096 0,12516127 ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,08387096 0,12506001 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,08387096 0,12495891 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,08387096 0,12485797 ! retinoid metabolic process GO:0001523 12 12 0,000 0,08387096 0,1247572 GO:0016101|diterpenoid metabolic process, ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,08387096 0,12465659 ! GPI anchor biosynthetic process GO:0006506 12 12 0,000 0,08387096 0,12455614 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 0,000 0,08387096 0,12445585 ! acute-phase response GO:0006953 12 12 0,000 0,08387096 0,12435573 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,08387096 0,12425576 ! vacuolar transport GO:0007034 12 12 0,000 0,08387096 0,12415596 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,08387096 0,12405632 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,08387096 0,12395683 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 0,000 0,08387096 0,12385751 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,08387096 0,12375834 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,08387096 0,12365934 ! male gonad development GO:0008584 12 12 0,000 0,08387096 0,12356049 ! regulation of alpha-beta T cell activation GO:0046634 12 12 0,000 0,08387096 0,1234618 ! renal system process GO:0003014 12 12 0,000 0,08387096 0,12336327 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,08387096 0,12326489 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,08387096 0,12316667 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,08387096 0,12306861 ! regulation of interleukin-6 production GO:0032675 12 12 0,000 0,08387096 0,1229707 ! pallium development GO:0021543 13 12 0,000 0,08387096 0,12287295 ! cell fate determination GO:0001709 12 12 0,000 0,08387096 0,12277535 ! positive regulation of multicellular organism growth GO:0040018 12 12 0,000 0,08387096 0,12267791 ! G1 phase GO:0051318 13 12 0,000 0,08387096 0,12258063 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,08387096 0,1224835 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,08387096 0,12238652 ! detection of light stimulus GO:0009583 13 12 0,000 0,08387096 0,12228969 ! synaptogenesis GO:0007416 12 12 0,000 0,08387096 0,12219302 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,08387096 0,1220965 ! hormone transport GO:0009914 12 12 0,000 0,08387096 0,12200014 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,08387096 0,12190392 ! heme biosynthetic process GO:0006783 12 12 0,000 0,08387096 0,12180786 ! spermatid differentiation GO:0048515 13 12 0,000 0,08387096 0,12171195 GO:0007286|spermatid development, ! aromatic compound catabolic process GO:0019439 13 12 0,000 0,08387096 0,12161619 ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,08387096 0,12152057 ! neural tube closure GO:0001843 13 12 0,000 0,08387096 0,12142511 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! negative regulation of translation GO:0017148 12 12 0,000 0,08387096 0,1213298 ! muscle contraction GO:0006936 67 67 1,000 0,08493329 0,12277024 ! sensory perception of sound GO:0007605 71 69 1,000 0,08931 0,12899555 GO:0050954|sensory perception of mechanical stimulus, ! response to nutrient levels GO:0031667 69 69 1,000 0,08931 0,12889454 ! regulation of leukocyte activation GO:0002694 69 69 1,000 0,08931 0,12879368 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,0905405 0,1304661 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,0905405 0,13036418 ! phenol metabolic process GO:0018958 13 13 0,000 0,0905405 0,13026241 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,0905405 0,1301608 ! gluconeogenesis GO:0006094 13 13 0,000 0,0905405 0,13005935 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,0905405 0,12995806 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,0905405 0,12985692 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,0905405 0,12975595 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 0,000 0,0905405 0,12965513 ! regeneration GO:0031099 13 13 0,000 0,0905405 0,12955446 ! keratinization GO:0031424 13 13 0,000 0,0905405 0,12945395 ! post-embryonic development GO:0009791 14 13 0,000 0,0905405 0,1293536 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,0905405 0,12925341 ! patterning of blood vessels GO:0001569 13 13 0,000 0,0905405 0,12915336 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,0905405 0,12905348 ! regulation of innate immune response GO:0045088 13 13 0,000 0,0905405 0,12895375 ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,0905405 0,12885417 ! autophagy GO:0006914 13 13 0,000 0,0905405 0,12875474 ! receptor metabolic process GO:0043112 14 13 0,000 0,0905405 0,12865547 ! negative regulation of protein catabolic process GO:0042177 13 13 0,000 0,0905405 0,12855635 ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,0905405 0,12845739 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,0905405 0,12835857 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of viral reproduction GO:0050792 13 13 0,000 0,0905405 0,12825991 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,0905405 0,1281614 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,0905405 0,12806304 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,0905405 0,12796484 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,0905405 0,12786678 ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 0,000 0,0905405 0,12776887 ! vasodilation GO:0042311 14 13 0,000 0,0905405 0,12767111 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,0905405 0,12757351 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 0,000 0,0905405 0,12747605 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,0905405 0,12737874 GO:0006664|glycolipid metabolic process, ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,0905405 0,12728158 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,0905405 0,12718456 ! immunoglobulin production GO:0002377 13 13 0,000 0,0905405 0,1270877 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,0905405 0,12699098 ! negative regulation of intracellular transport GO:0032387 13 13 0,000 0,0905405 0,12689441 ! regulation of cell-substrate adhesion GO:0010810 14 13 0,000 0,0905405 0,12679798 GO:0001952|regulation of cell-matrix adhesion, ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,0905405 0,12670171 ! response to cytokine stimulus GO:0034097 13 13 0,000 0,0905405 0,12660557 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,0905405 0,12650959 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,0905405 0,12641375 ! alkene biosynthetic process GO:0043450 13 13 0,000 0,0905405 0,12631805 GO:0019370|leukotriene biosynthetic process, ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,0905405 0,1262225 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,0905405 0,1261271 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,0905405 0,12603183 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,0905405 0,12593671 ! blastocyst development GO:0001824 13 13 0,000 0,0905405 0,12584174 ! telomere organization GO:0032200 13 13 0,000 0,0905405 0,12574691 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,0905405 0,12565222 ! regulation of amine transport GO:0051952 13 13 0,000 0,0905405 0,12555767 ! tissue homeostasis GO:0001894 13 13 0,000 0,0905405 0,12546327 GO:0048871|multicellular organismal homeostasis, ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,0905405 0,12536901 ! translational elongation GO:0006414 71 71 1,000 0,09375309 0,12971993 ! regulation of cell activation GO:0050865 71 71 1,000 0,09375309 0,12962262 ! muscle system process GO:0003012 72 72 1,000 0,09599867 0,13262785 ! sensory organ development GO:0007423 72 72 1,000 0,09599867 0,13252851 ! response to extracellular stimulus GO:0009991 72 72 1,000 0,09599867 0,13242931 ! regulation of cytokine production GO:0001817 72 72 1,000 0,09599867 0,13233026 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,09716246 0,13383439 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,09716246 0,13373444 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,09716246 0,13363464 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,09716246 0,13353498 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,09716246 0,13343548 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,09716246 0,13333612 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,09716246 0,13323691 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,09716246 0,13313785 ! vesicle docking GO:0048278 14 14 0,000 0,09716246 0,13303894 ! superoxide metabolic process GO:0006801 15 14 0,000 0,09716246 0,13294017 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,09716246 0,13284155 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,09716246 0,13274308 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,09716246 0,13264475 ! hair cycle GO:0042633 14 14 0,000 0,09716246 0,13254657 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,09716246 0,13244853 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,09716246 0,13235064 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! response to retinoic acid GO:0032526 14 14 0,000 0,09716246 0,13225289 GO:0033189|response to vitamin A, ! multicellular organismal response to stress GO:0033555 14 14 0,000 0,09716246 0,13215529 ! lysosome organization GO:0007040 14 14 0,000 0,09716246 0,13205783 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,09716246 0,13196051 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,09716246 0,13186334 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 0,000 0,09716246 0,13176631 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 14 14 0,000 0,09716246 0,13166942 ! primary neural tube formation GO:0014020 15 14 0,000 0,09716246 0,13157268 ! peptide cross-linking GO:0018149 14 14 0,000 0,09716246 0,13147607 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,09716246 0,13137961 ! response to organic cyclic substance GO:0014070 15 14 0,000 0,09716246 0,13128329 ! leukotriene metabolic process GO:0006691 14 14 0,000 0,09716246 0,13118712 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,09716246 0,13109108 ! formation of primary germ layer GO:0001704 14 14 0,000 0,09716246 0,13099518 GO:0001707|mesoderm formation, ! DNA modification GO:0006304 14 14 0,000 0,09716246 0,13089942 ! collagen fibril organization GO:0030199 14 14 0,000 0,09716246 0,13080381 ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,09716246 0,13070833 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,09716246 0,13061299 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,09716246 0,13051779 ! positive regulation of osteoblast differentiation GO:0045669 14 14 0,000 0,09716246 0,13042273 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,09716246 0,13032781 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,09716246 0,13023303 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,09716246 0,13013838 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,10373716 0,13884356 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,10373716 0,1387428 ! positive regulation of ossification GO:0045778 15 15 0,000 0,10373716 0,13864219 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,10373716 0,13854173 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,10373716 0,13844141 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,10373716 0,13834123 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,10373716 0,1382412 ! response to vitamin GO:0033273 15 15 0,000 0,10373716 0,13814132 ! regulation of transcription factor import into nucleus GO:0042990 15 15 0,000 0,10373716 0,13804158 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,10373716 0,13794198 ! ovarian follicle development GO:0001541 15 15 0,000 0,10373716 0,13784252 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 0,000 0,10373716 0,13774321 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,10373716 0,13764405 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,10373716 0,13754502 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,10373716 0,13744614 ! heme metabolic process GO:0042168 15 15 0,000 0,10373716 0,1373474 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,10373716 0,1372488 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,10373716 0,13715035 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,10373716 0,13705203 GO:0030500|regulation of bone mineralization, ! regulation of production of molecular mediator of immune response GO:0002700 15 15 0,000 0,10373716 0,13695385 ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,10373716 0,13685582 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,10373716 0,13675793 ! phospholipid transport GO:0015914 15 15 0,000 0,10373716 0,13666017 ! leukocyte homeostasis GO:0001776 15 15 0,000 0,10373716 0,13656256 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,10373716 0,13646508 ! nicotinamide metabolic process GO:0006769 15 15 0,000 0,10373716 0,13636775 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of B cell activation GO:0050871 15 15 0,000 0,10373716 0,13627055 ! cellular alkene metabolic process GO:0043449 15 15 0,000 0,10373716 0,13617349 ! negative regulation of transcription factor activity GO:0043433 16 15 0,000 0,10373716 0,13607657 GO:0090048|negative regulation of transcription regulator activity, ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,10373716 0,13597979 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,10373716 0,13588314 ! positive regulation of multicellular organismal process GO:0051240 76 76 1,000 0,10513341 0,13761426 ! regulation of protein modification process GO:0031399 79 78 1,000 0,10978765 0,14360442 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 0,000 0,11026493 0,14412643 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 0,000 0,11026493 0,14402428 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! alkaloid metabolic process GO:0009820 16 16 0,000 0,11026493 0,14392228 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,11026493 0,14382043 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,11026493 0,14371871 ! learning GO:0007612 16 16 0,000 0,11026493 0,14361715 ! circadian rhythm GO:0007623 16 16 0,000 0,11026493 0,14351572 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,11026493 0,14341444 ! vacuole organization GO:0007033 16 16 0,000 0,11026493 0,1433133 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,11026493 0,14321231 ! vesicle targeting GO:0006903 17 16 0,000 0,11026493 0,14311145 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,11026493 0,14301074 ! positive regulation of cell development GO:0010720 16 16 0,000 0,11026493 0,14291017 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,11026493 0,14280974 ! lymphocyte proliferation GO:0046651 16 16 0,000 0,11026493 0,14270945 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,11026493 0,14260931 ! pentose metabolic process GO:0019321 16 16 0,000 0,11026493 0,1425093 ! fatty acid transport GO:0015908 16 16 0,000 0,11026493 0,14240943 ! positive regulation of MAPKKK cascade GO:0043410 17 16 0,000 0,11026493 0,14230971 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,11026493 0,14221012 ! polyol metabolic process GO:0019751 16 16 0,000 0,11026493 0,14211067 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,11026493 0,14201136 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,11026493 0,14191219 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,11026493 0,14181316 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,11026493 0,14171427 GO:0001841|neural tube formation, ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,11026493 0,14161551 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,11026493 0,1415169 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,11026493 0,14141841 ! regulation of coagulation GO:0050818 17 16 0,000 0,11026493 0,14132007 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,1167461 0,14952263 ! phosphoinositide biosynthetic process GO:0046489 17 17 0,000 0,1167461 0,14941879 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,1167461 0,1493151 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,1167461 0,14921155 ! leukocyte adhesion GO:0007159 17 17 0,000 0,1167461 0,14910815 ! dicarboxylic acid metabolic process GO:0043648 18 17 0,000 0,1167461 0,14900489 ! sensory perception of smell GO:0007608 17 17 0,000 0,1167461 0,14890177 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,1167461 0,1487988 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,1167461 0,14869596 ! development of primary male sexual characteristics GO:0046546 17 17 0,000 0,1167461 0,14859327 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,1167461 0,14849072 ! response to toxin GO:0009636 18 17 0,000 0,1167461 0,14838832 ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,1167461 0,14828605 GO:0002764|immune response-regulating signal transduction, ! positive regulation of protein secretion GO:0050714 17 17 0,000 0,1167461 0,14818392 ! regulation of osteoblast differentiation GO:0045667 17 17 0,000 0,1167461 0,14808194 ! pyridine nucleotide metabolic process GO:0019362 17 17 0,000 0,1167461 0,1479801 ! pigmentation GO:0043473 17 17 0,000 0,1167461 0,14787839 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,1167461 0,14777683 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,1167461 0,1476754 ! gene silencing GO:0016458 17 17 0,000 0,1167461 0,14757411 ! lymphocyte activation GO:0046649 82 81 1,000 0,11687044 0,14763003 ! blood vessel morphogenesis GO:0048514 84 83 1,000 0,12165634 0,1535703 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,12318099 0,15538848 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,12318099 0,1552822 ! icosanoid biosynthetic process GO:0046456 18 18 0,000 0,12318099 0,15517606 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,12318099 0,15507006 ! membrane docking GO:0022406 18 18 0,000 0,12318099 0,15496421 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 0,000 0,12318099 0,15485851 ! mononuclear cell proliferation GO:0032943 18 18 0,000 0,12318099 0,15475295 GO:0070661|leukocyte proliferation, ! response to calcium ion GO:0051592 18 18 0,000 0,12318099 0,15464753 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,12318099 0,15454226 ! striated muscle contraction GO:0006941 18 18 0,000 0,12318099 0,15443712 ! negative regulation of DNA binding GO:0043392 19 18 0,000 0,12318099 0,15433214 ! ceramide metabolic process GO:0006672 18 18 0,000 0,12318099 0,15422729 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,12318099 0,15412259 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! hexose biosynthetic process GO:0019319 18 18 0,000 0,12318099 0,15401803 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,12318099 0,15391361 ! BMP signaling pathway GO:0030509 18 18 0,000 0,12318099 0,15380933 ! negative regulation of catabolic process GO:0009895 18 18 0,000 0,12318099 0,1537052 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,12318099 0,1536012 ! cellular amino acid derivative metabolic process GO:0006575 87 84 1,000 0,12406761 0,15460216 ! positive regulation of cell differentiation GO:0045597 87 85 1,000 0,12649068 0,15751509 ! hexose metabolic process GO:0019318 87 86 1,000 0,12892529 0,16043842 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,12956994 0,16113185 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,12956994 0,1610232 GO:0006956|complement activation, ! glial cell differentiation GO:0010001 19 19 0,000 0,12956994 0,16091469 ! regulation of JAK-STAT cascade GO:0046425 19 19 0,000 0,12956994 0,16080633 ! peroxisome organization GO:0007031 19 19 0,000 0,12956994 0,16069812 ! positive regulation of T cell proliferation GO:0042102 19 19 0,000 0,12956994 0,16059005 ! regulation of striated muscle tissue development GO:0016202 20 19 0,000 0,12956994 0,16048212 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,12956994 0,16037435 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,12956994 0,16026671 ! positive regulation of T cell differentiation GO:0045582 19 19 0,000 0,12956994 0,16015922 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,12956994 0,16005188 ! regulation of protein stability GO:0031647 19 19 0,000 0,12956994 0,15994468 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,12956994 0,15983762 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,12956994 0,1597307 ! response to heat GO:0009408 19 19 0,000 0,12956994 0,15962393 ! vesicle localization GO:0051648 20 19 0,000 0,12956994 0,1595173 ! male gamete generation GO:0048232 90 88 1,000 0,13382793 0,16464945 GO:0007283|spermatogenesis, ! regulation of muscle development GO:0048634 21 20 0,000 0,13591326 0,16710349 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,13591326 0,16699209 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,13591326 0,16688084 ! negative regulation of binding GO:0051100 21 20 0,000 0,13591326 0,16676973 ! nucleus organization GO:0006997 20 20 0,000 0,13591326 0,16665877 ! phagocytosis GO:0006909 21 20 0,000 0,13591326 0,16654796 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 0,000 0,13591326 0,1664373 ! protein targeting to membrane GO:0006612 22 20 0,000 0,13591326 0,16632678 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,13591326 0,16621641 ! chromatin remodeling GO:0006338 20 20 0,000 0,13591326 0,16610619 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,13591326 0,16599611 ! lipid oxidation GO:0034440 20 20 0,000 0,13591326 0,16588618 GO:0019395|fatty acid oxidation, ! female gamete generation GO:0007292 20 20 0,000 0,13591326 0,1657764 ! negative regulation of neuron apoptosis GO:0043524 21 20 0,000 0,13591326 0,16566676 ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,13591326 0,16555726 ! RNA modification GO:0009451 20 20 0,000 0,13591326 0,16544791 ! single fertilization GO:0007338 21 20 0,000 0,13591326 0,1653387 ! regulation of B cell activation GO:0050864 20 20 0,000 0,13591326 0,16522964 ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 1,000 0,13629541 0,165585 ! regulation of Ras protein signal transduction GO:0046578 90 90 1,000 0,13877329 0,1684843 ! brain development GO:0007420 91 90 1,000 0,13877329 0,16837338 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 1,000 0,14126129 0,17127932 ! DNA replication GO:0006260 91 91 1,000 0,14126129 0,17116671 ! mRNA catabolic process GO:0006402 21 21 0,000 0,14221127 0,17220458 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,14221127 0,17209151 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! protein amino acid lipidation GO:0006497 21 21 0,000 0,14221127 0,17197859 ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,14221127 0,17186581 ! Notch signaling pathway GO:0007219 22 21 0,000 0,14221127 0,17175319 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,14221127 0,17164071 ! ear morphogenesis GO:0042471 21 21 0,000 0,14221127 0,17152838 ! organic anion transport GO:0015711 21 21 0,000 0,14221127 0,1714162 ! cholesterol transport GO:0030301 21 21 0,000 0,14221127 0,17130416 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,14221127 0,17119227 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,14221127 0,17108053 GO:0032313|regulation of Rab GTPase activity, ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,14221127 0,17096893 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 0,000 0,14221127 0,17085747 ! regulation of proteolysis GO:0030162 21 21 0,000 0,14221127 0,17074617 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 0,000 0,14221127 0,170635 ! negative regulation of protein transport GO:0051224 21 21 0,000 0,14221127 0,17052399 ! fatty acid metabolic process GO:0006631 93 92 1,000 0,14375916 0,17226796 ! positive regulation of immune system process GO:0002684 92 92 1,000 0,14375916 0,17215603 ! tissue morphogenesis GO:0048729 94 93 1,000 0,14626661 0,17504504 ! RNA export from nucleus GO:0006405 22 22 0,000 0,14846428 0,17755981 ! cellular amide metabolic process GO:0043603 22 22 0,000 0,14846428 0,17744467 ! regulation of ion transport GO:0043269 22 22 0,000 0,14846428 0,17732967 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 0,000 0,14846428 0,17721481 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! maintenance of protein location in cell GO:0032507 23 22 0,000 0,14846428 0,17710011 ! ovulation cycle process GO:0022602 22 22 0,000 0,14846428 0,17698556 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,14846428 0,17687115 ! cell chemotaxis GO:0060326 23 22 0,000 0,14846428 0,1767569 GO:0030595|leukocyte chemotaxis, ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,14846428 0,17664278 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,14846428 0,17652882 ! male sex differentiation GO:0046661 22 22 0,000 0,14846428 0,17641501 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,14846428 0,17630134 ! biopolymer methylation GO:0043414 22 22 0,000 0,14846428 0,17618781 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 0,000 0,14846428 0,17607444 ! detection of external stimulus GO:0009581 23 22 0,000 0,14846428 0,17596121 ! neuron migration GO:0001764 22 22 0,000 0,14846428 0,17584812 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,14846428 0,17573518 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,14846428 0,17562238 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 0,000 0,14846428 0,17550973 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,14846428 0,17539723 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,14846428 0,17528486 ! regulation of response to stress GO:0080134 97 94 1,000 0,1487834 0,17554917 ! blood vessel development GO:0001568 95 94 1,000 0,1487834 0,17543685 ! epidermis development GO:0008544 94 94 1,000 0,1487834 0,17532468 ! vasculature development GO:0001944 97 96 1,000 0,15384391 0,1811721 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,15467262 0,1820317 ! viral infectious cycle GO:0019058 23 23 0,000 0,15467262 0,18191553 ! response to estrogen stimulus GO:0043627 23 23 0,000 0,15467262 0,18179952 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,15467262 0,18168365 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,15467262 0,18156792 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,15467262 0,18145235 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,15467262 0,18133692 ! lipoprotein biosynthetic process GO:0042158 23 23 0,000 0,15467262 0,18122164 ! female gonad development GO:0008585 23 23 0,000 0,15467262 0,18110651 ! Rho protein signal transduction GO:0007266 24 23 0,000 0,15467262 0,18099152 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,15467262 0,18087668 ! cell projection assembly GO:0030031 25 23 0,000 0,15467262 0,18076198 ! posttranscriptional regulation of gene expression GO:0010608 98 98 1,000 0,15893867 0,18562989 ! glycoprotein metabolic process GO:0009100 99 98 1,000 0,15893867 0,18551232 ! blood circulation GO:0008015 99 98 1,000 0,15893867 0,18539491 GO:0003013|circulatory system process, ! gliogenesis GO:0042063 24 24 0,000 0,1608366 0,1874901 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,1608366 0,18737158 ! cellular amino acid biosynthetic process GO:0008652 24 24 0,000 0,1608366 0,18725322 ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,1608366 0,187135 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,1608366 0,18701694 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,1608366 0,18689902 ! ovulation cycle GO:0042698 24 24 0,000 0,1608366 0,18678125 ! fertilization GO:0009566 25 24 0,000 0,1608366 0,18666363 ! maintenance of protein location GO:0045185 25 24 0,000 0,1608366 0,18654616 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 0,000 0,1608366 0,18642883 ! anti-apoptosis GO:0006916 100 99 1,000 0,16149826 0,18707812 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 1,000 0,16406566 0,1899328 ! response to other organism GO:0051707 101 100 1,000 0,16406566 0,18981357 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,16695652 0,19303692 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,16695652 0,1929159 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,16695652 0,19279502 ! cellular component disassembly GO:0022411 26 25 0,000 0,16695652 0,1926743 ! endosome transport GO:0016197 25 25 0,000 0,16695652 0,19255373 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,16695652 0,19243331 ! development of primary female sexual characteristics GO:0046545 25 25 0,000 0,16695652 0,19231304 GO:0046660|female sex differentiation, ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,16695652 0,19219292 ! excretion GO:0007588 25 25 0,000 0,16695652 0,19207295 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 0,000 0,16695652 0,19195312 ! gastrulation GO:0007369 25 25 0,000 0,16695652 0,19183345 ! icosanoid metabolic process GO:0006690 25 25 0,000 0,16695652 0,19171393 ! regulation of endocytosis GO:0030100 25 25 0,000 0,16695652 0,19159456 ! JAK-STAT cascade GO:0007259 26 25 0,000 0,16695652 0,19147533 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 0,000 0,17303269 0,19832043 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 0,000 0,17303269 0,19819717 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,17303269 0,19807407 ! negative regulation of cell migration GO:0030336 26 26 0,000 0,17303269 0,19795112 ! cellular defense response GO:0006968 26 26 0,000 0,17303269 0,19782832 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,17303269 0,19770567 ! regulation of protein secretion GO:0050708 26 26 0,000 0,17303269 0,19758318 ! germ cell development GO:0007281 27 26 0,000 0,17303269 0,19746083 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,17303269 0,19733864 GO:0035150|regulation of tube size, ! pigment metabolic process GO:0042440 26 26 0,000 0,17303269 0,1972166 ! maintenance of location in cell GO:0051651 27 26 0,000 0,17303269 0,19709471 ! chloride transport GO:0006821 27 27 0,000 0,17906542 0,20384038 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,17906542 0,20371455 ! learning or memory GO:0007611 28 27 0,000 0,17906542 0,20358888 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,17906542 0,20346336 ! cAMP-mediated signaling GO:0019933 27 27 0,000 0,17906542 0,203338 ! inner ear development GO:0048839 27 27 0,000 0,17906542 0,20321279 ! defense response to bacterium GO:0042742 27 27 0,000 0,17906542 0,20308774 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,17906542 0,20296284 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,17906542 0,20283809 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,18505502 0,20949411 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,18505502 0,20936551 GO:0007254|JNK cascade, ! regulation of muscle contraction GO:0006937 28 28 0,000 0,18505502 0,20923706 ! unsaturated fatty acid metabolic process GO:0033559 28 28 0,000 0,18505502 0,20910877 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,18505502 0,20898064 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,18505502 0,20885267 ! glycerophospholipid biosynthetic process GO:0046474 30 29 0,000 0,19100179 0,21543225 ! phosphoinositide metabolic process GO:0030384 29 29 0,000 0,19100179 0,21530049 ! leukocyte migration GO:0050900 30 29 0,000 0,19100179 0,21516889 ! antigen processing and presentation GO:0019882 29 29 0,000 0,19100179 0,21503745 ! tRNA processing GO:0008033 29 29 0,000 0,19100179 0,21490617 ! regulation of gene expression, epigenetic GO:0040029 29 29 0,000 0,19100179 0,21477505 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,19100179 0,21464409 ! transition metal ion transport GO:0000041 31 30 0,000 0,19690603 0,22114431 ! RNA catabolic process GO:0006401 30 30 0,000 0,19690603 0,22100963 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,19690603 0,22087511 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,19690603 0,22074076 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,19690603 0,22060657 ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,19690603 0,22047254 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 0,000 0,19690603 0,22033868 ! response to temperature stimulus GO:0009266 30 30 0,000 0,19690603 0,22020498 ! regulation of ossification GO:0030278 30 30 0,000 0,19690603 0,22007144 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,19690603 0,21993806 GO:0019724|B cell mediated immunity, ! water-soluble vitamin metabolic process GO:0006767 30 30 0,000 0,19690603 0,21980485 ! vesicle organization GO:0016050 30 30 0,000 0,19690603 0,2196718 ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,19690603 0,2195389 ! regulation of translational initiation GO:0006446 31 31 0,000 0,20276803 0,22593801 ! membrane fusion GO:0006944 31 31 0,000 0,20276803 0,22580149 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,20276803 0,22566514 ! lipoprotein metabolic process GO:0042157 31 31 0,000 0,20276803 0,22552895 ! ion transmembrane transport GO:0034220 31 31 0,000 0,20276803 0,22539293 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! glycerolipid biosynthetic process GO:0045017 32 31 0,000 0,20276803 0,22525707 ! digestion GO:0007586 31 31 0,000 0,20276803 0,22512137 ! nucleoside metabolic process GO:0009116 31 31 0,000 0,20276803 0,22498584 ! regulation of heart contraction GO:0008016 31 31 0,000 0,20276803 0,22485046 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,20276803 0,22471526 ! extracellular matrix organization GO:0030198 31 31 0,000 0,20276803 0,22458021 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,20276803 0,22444533 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,20276803 0,22431061 ! negative regulation of cell motion GO:0051271 31 31 0,000 0,20276803 0,22417605 ! lipid modification GO:0030258 32 32 0,000 0,20858809 0,23047233 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,20858809 0,23033424 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,20858809 0,23019631 ! cell maturation GO:0048469 32 32 0,000 0,20858809 0,23005855 ! protein maturation by peptide bond cleavage GO:0051605 32 32 0,000 0,20858809 0,22992096 ! maintenance of location GO:0051235 33 32 0,000 0,20858809 0,22978353 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,2143665 0,23600804 ! amino acid transport GO:0006865 33 33 0,000 0,2143665 0,23586714 ! activation of protein kinase activity GO:0032147 35 33 0,000 0,2143665 0,23572641 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,2143665 0,23558585 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,2143665 0,23544545 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 0,000 0,2143665 0,23530522 ! regulation of neuron differentiation GO:0045664 34 33 0,000 0,2143665 0,23516516 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,2143665 0,23502526 ! regulation of actin filament length GO:0030832 34 34 0,000 0,22010357 0,24117174 ! response to metal ion GO:0010038 34 34 0,000 0,22010357 0,24102845 ! ear development GO:0043583 34 34 0,000 0,22010357 0,24088532 ! regulation of protein catabolic process GO:0042176 35 34 0,000 0,22010357 0,24074236 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,22010357 0,24059957 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,22010357 0,24045695 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,22010357 0,2403145 ! secondary metabolic process GO:0019748 34 34 0,000 0,22010357 0,24017222 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,22010357 0,2400301 ! detection of stimulus GO:0051606 36 34 0,000 0,22010357 0,23988816 ! acute inflammatory response GO:0002526 35 35 0,000 0,22579957 0,24595071 ! regulation of cellular component size GO:0032535 35 35 0,000 0,22579957 0,24580544 ! regulation of cytokine biosynthetic process GO:0042035 35 35 0,000 0,22579957 0,24566033 ! inorganic anion transport GO:0015698 35 35 0,000 0,22579957 0,2455154 ! regulation of immune effector process GO:0002697 35 35 0,000 0,22579957 0,24537064 ! hydrogen transport GO:0006818 36 36 0,000 0,23145479 0,25136782 GO:0015992|proton transport, ! response to inorganic substance GO:0010035 36 36 0,000 0,23145479 0,25121978 ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,23145479 0,25107192 ! female pregnancy GO:0007565 37 36 0,000 0,23145479 0,25092423 ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,23145479 0,25077671 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,23145479 0,25062937 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,23145479 0,2504822 ! gonad development GO:0008406 36 36 0,000 0,23145479 0,2503352 ! activation of immune response GO:0002253 36 36 0,000 0,23145479 0,25018838 ! regulation of adenylate cyclase activity GO:0045761 37 37 0,000 0,23706953 0,25610735 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,23706953 0,25595732 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,23706953 0,25580746 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! cellular amino acid catabolic process GO:0009063 38 37 0,000 0,23706953 0,25565778 ! neurotransmitter transport GO:0006836 40 38 0,000 0,24264406 0,26151638 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,24264406 0,26136354 ! exocytosis GO:0006887 40 38 0,000 0,24264406 0,26121087 ! RNA elongation GO:0006354 38 38 0,000 0,24264406 0,26105838 ! regulation of neurological system process GO:0031644 38 38 0,000 0,24264406 0,26090607 ! regulation of cAMP biosynthetic process GO:0030817 39 39 0,000 0,24817867 0,26670163 ! positive regulation of protein modification process GO:0031401 39 39 0,000 0,24817867 0,26654621 ! response to unfolded protein GO:0006986 39 39 0,000 0,24817867 0,26639097 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,24817867 0,26623591 ! fatty acid biosynthetic process GO:0006633 39 39 0,000 0,24817867 0,26608103 ! cytokine-mediated signaling pathway GO:0019221 39 39 0,000 0,24817867 0,26592633 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,24817867 0,26577181 ! regulation of MAPKKK cascade GO:0043408 41 39 0,000 0,24817867 0,26561748 ! positive regulation of T cell activation GO:0050870 39 39 0,000 0,24817867 0,26546332 ! developmental maturation GO:0021700 39 39 0,000 0,24817867 0,26530933 ! regulation of cAMP metabolic process GO:0030814 40 40 0,000 0,25367364 0,27102639 ! DNA catabolic process GO:0006308 41 40 0,000 0,25367364 0,27086936 ! regulation of nucleotide biosynthetic process GO:0030808 41 41 0,000 0,25912924 0,27653456 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! amine catabolic process GO:0009310 42 41 0,000 0,25912924 0,27637453 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,25912924 0,27621469 ! phospholipid biosynthetic process GO:0008654 42 41 0,000 0,25912924 0,27605502 ! leukocyte mediated immunity GO:0002443 41 41 0,000 0,25912924 0,27589555 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,25912924 0,27573625 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,26454576 0,28133746 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 0,000 0,26454576 0,28117522 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,26454576 0,28101316 ! development of primary sexual characteristics GO:0045137 42 42 0,000 0,26454576 0,28085128 ! protein ubiquitination GO:0016567 43 42 0,000 0,26454576 0,28068959 ! negative regulation of ligase activity GO:0051352 43 42 0,000 0,26454576 0,28052809 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! response to protein stimulus GO:0051789 42 42 0,000 0,26454576 0,28036678 ! one-carbon metabolic process GO:0006730 42 42 0,000 0,26454576 0,28020565 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 0,000 0,26454576 0,2800447 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 0,000 0,26992345 0,28557344 ! homeostasis of number of cells GO:0048872 44 43 0,000 0,26992345 0,2854096 ! regulation of nucleotide metabolic process GO:0006140 43 43 0,000 0,26992345 0,28524594 ! humoral immune response GO:0006959 44 44 0,000 0,27526261 0,29072149 ! mRNA transport GO:0051028 44 44 0,000 0,27526261 0,29055498 ! vitamin metabolic process GO:0006766 44 44 0,000 0,27526261 0,29038866 ! positive regulation of lymphocyte activation GO:0051251 44 44 0,000 0,27526261 0,29022254 ! amine biosynthetic process GO:0009309 46 45 0,000 0,2805635 0,29564239 ! regulation of actin cytoskeleton organization GO:0032956 46 45 0,000 0,2805635 0,29547345 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,2805635 0,2953047 ! protein processing GO:0016485 45 45 0,000 0,2805635 0,29513615 ! regulation of actin filament-based process GO:0032970 47 46 0,000 0,28582639 0,30050087 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 0,000 0,28582639 0,30032955 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,28582639 0,30015842 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 0,000 0,29105154 0,30547152 ! regulation of blood pressure GO:0008217 48 47 0,000 0,29105154 0,30529766 ! amine transport GO:0015837 47 47 0,000 0,29105154 0,305124 ! rhythmic process GO:0048511 47 47 0,000 0,29105154 0,30495053 ! calcium ion transport GO:0006816 48 48 0,000 0,29623922 0,31020959 ! glycerophospholipid metabolic process GO:0006650 49 48 0,000 0,29623922 0,31003344 ! DNA recombination GO:0006310 48 48 0,000 0,29623922 0,30985748 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,30138969 0,31506591 ! divalent metal ion transport GO:0070838 49 49 0,000 0,30138969 0,3148873 ! response to nutrient GO:0007584 49 49 0,000 0,30138969 0,3147089 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,30138969 0,31453069 ! positive regulation of cell activation GO:0050867 49 49 0,000 0,30138969 0,31435269 GO:0002696|positive regulation of leukocyte activation, ! chromatin assembly GO:0031497 50 50 0,000 0,30650322 0,31950534 GO:0006334|nucleosome assembly, ! RNA transport GO:0050658 50 50 0,000 0,30650322 0,31932472 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 0,000 0,30650322 0,31914432 ! nitrogen compound catabolic process GO:0044270 51 50 0,000 0,30650322 0,31896411 ! transcription initiation GO:0006352 50 50 0,000 0,30650322 0,31878411 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,31158006 0,32388159 ! positive regulation of immune response GO:0050778 51 51 0,000 0,31158006 0,32369902 ! rRNA metabolic process GO:0016072 51 51 0,000 0,31158006 0,32351665 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,31158006 0,32333449 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,31158006 0,32315254 ! protein maturation GO:0051604 51 51 0,000 0,31158006 0,32297079 ! RNA localization GO:0006403 52 52 0,000 0,31662048 0,32801099 ! cholesterol metabolic process GO:0008203 52 52 0,000 0,31662048 0,32782671 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 0,000 0,31662048 0,32764264 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,31662048 0,32745878 ! sodium ion transport GO:0006814 53 53 0,000 0,32162472 0,33244777 ! tRNA metabolic process GO:0006399 53 53 0,000 0,32162472 0,33226142 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,32162472 0,33207528 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,32162472 0,33188934 ! response to virus GO:0009615 54 54 0,000 0,32659305 0,33682764 ! nucleosome organization GO:0034728 55 55 0,000 0,33152571 0,34172365 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,33152571 0,34153264 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,33642296 0,34638409 ! ATP metabolic process GO:0046034 57 57 0,000 0,34128504 0,35119393 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,34128504 0,35099795 ! innate immune response GO:0045087 58 58 0,000 0,34611221 0,35576397 ! carboxylic acid transport GO:0046942 59 59 0,000 0,3509047 0,36048905 GO:0015849|organic acid transport, ! sterol metabolic process GO:0016125 59 59 0,000 0,3509047 0,36028822 ! cellular aromatic compound metabolic process GO:0006725 60 59 0,000 0,3509047 0,36008762 ! immune effector process GO:0002252 59 59 0,000 0,3509047 0,35988724 ! potassium ion transport GO:0006813 60 60 0,000 0,35566277 0,36456423 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 0,000 0,35566277 0,36436158 ! proteasomal protein catabolic process GO:0010498 62 61 0,000 0,36038665 0,36899588 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! carboxylic acid catabolic process GO:0046395 63 61 0,000 0,36038665 0,368791 GO:0016054|organic acid catabolic process, ! positive regulation of cellular protein metabolic process GO:0032270 61 61 0,000 0,36038665 0,36858634 ! lipid transport GO:0006869 62 62 0,000 0,36507658 0,3731759 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,36507658 0,37296904 ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,36507658 0,3727624 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,36507658 0,372556 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,36973281 0,37709882 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,36973281 0,37689025 ! positive regulation of protein metabolic process GO:0051247 64 64 0,000 0,37435557 0,38139155 ! anion transport GO:0006820 65 65 0,000 0,3789451 0,38585404 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,38350163 0,39027802 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,38350163 0,39006264 ! negative regulation of protein metabolic process GO:0051248 66 66 0,000 0,38350163 0,38984749 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,38802539 0,39422866 ! Ras protein signal transduction GO:0007265 69 67 0,000 0,38802539 0,39401146 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,39251662 0,39835249 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,39251662 0,39813326 ! regulation of translation GO:0006417 69 69 0,000 0,39697554 0,4024345 ! carboxylic acid biosynthetic process GO:0046394 70 70 0,000 0,40140238 0,40669851 GO:0016053|organic acid biosynthetic process, ! oxidative phosphorylation GO:0006119 71 71 0,000 0,40579737 0,41092558 ! calcium ion homeostasis GO:0055074 71 71 0,000 0,40579737 0,41069992 GO:0006874|cellular calcium ion homeostasis, ! ribosome biogenesis GO:0042254 71 71 0,000 0,40579737 0,41047451 ! negative regulation of signal transduction GO:0009968 71 71 0,000 0,40579737 0,41024934 ! secretion by cell GO:0032940 75 72 0,000 0,41016073 0,41443324 ! electron transport chain GO:0022900 75 74 0,000 0,41879346 0,42292403 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,42306327 0,42700198 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,42306327 0,42676826 ! negative regulation of cell communication GO:0010648 76 76 0,000 0,42730234 0,43080865 ! cellular metal ion homeostasis GO:0006875 77 77 0,000 0,43151087 0,43481386 ! positive regulation of protein kinase cascade GO:0010740 79 78 0,000 0,4356891 0,43878416 ! metal ion homeostasis GO:0055065 78 78 0,000 0,4356891 0,43854452 ! regulation of immune response GO:0050776 78 78 0,000 0,4356891 0,43830514 ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,44395546 0,44637748 ! lipid catabolic process GO:0016042 82 81 0,000 0,44804402 0,45024271 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,45613296 0,45812155 ! ncRNA processing GO:0034470 83 83 0,000 0,45613296 0,45787203 ! nitrogen compound biosynthetic process GO:0044271 86 85 0,000 0,46410569 0,46562155 ! organophosphate metabolic process GO:0019637 87 86 0,000 0,46804899 0,46932224 GO:0006644|phospholipid metabolic process, ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,47585047 0,47688549 ! chemotaxis GO:0006935 90 89 0,000 0,47970905 0,48049118 GO:0042330|taxis, ! visual perception GO:0007601 93 92 0,000 0,49111852 0,49165206 GO:0050953|sensory perception of light stimulus, ! endocytosis GO:0006897 99 98 0,000 0,51320674 0,51348536 GO:0010324|membrane invagination, ! regulation of system process GO:0044057 98 98 0,000 0,51320674 0,51320674