pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6291-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of protein export from nucleus GO:0046825 6 6 4,000 3,479E-11 8,001E-08 ! negative regulation of peptide secretion GO:0002792 6 5 3,000 5,224E-09 6,008E-06 GO:0046676|negative regulation of insulin secretion, ! carbohydrate homeostasis GO:0033500 39 33 5,000 3,124E-08 2,395E-05 GO:0042593|glucose homeostasis, ! organ growth GO:0035265 11 7 3,000 3,624E-08 2,084E-05 ! regulation of growth hormone secretion GO:0060123 11 7 3,000 3,624E-08 1,667E-05 ! DNA integrity checkpoint GO:0031570 57 34 5,000 3,776E-08 1,447E-05 ! regulation of intracellular protein transport GO:0033157 59 35 5,000 4,536E-08 1,49E-05 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 3,000 7,217E-08 2,075E-05 ! cell cycle checkpoint GO:0000075 108 64 6,000 8,258E-08 2,11E-05 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 5,000 1,419E-07 3,263E-05 ! cellular response to hormone stimulus GO:0032870 109 74 6,000 2,282E-07 4,772E-05 ! regulation of intracellular transport GO:0032386 78 49 5,000 3,661E-07 7,016E-05 ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 5,943E-07 1,052E-04 ! DNA damage checkpoint GO:0000077 53 31 4,000 8,785E-07 1,443E-04 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 1,364E-06 2,092E-04 ! positive regulation of glycolysis GO:0045821 11 5 2,000 1,856E-06 2,668E-04 ! positive regulation of hormone secretion GO:0046887 24 17 3,000 2,357E-06 3,189E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 3,265E-06 4,172E-04 ! ER overload response GO:0006983 7 6 2,000 3,697E-06 4,475E-04 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 2,000 3,697E-06 4,251E-04 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 4,711E-06 5,159E-04 ! regulation of protein transport GO:0051223 114 76 5,000 5,047E-06 5,276E-04 GO:0070201|regulation of establishment of protein localization, ! regulation of insulin secretion GO:0050796 26 21 3,000 5,824E-06 5,824E-04 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 5,925E-06 5,678E-04 ! regulation of protein localization GO:0032880 132 85 5,000 9,682E-06 8,907E-04 ! regulation of multicellular organism growth GO:0040014 65 50 4,000 1,004E-05 8,884E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 1,02E-05 8,692E-04 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 2,000 1,026E-05 8,431E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,026E-05 8,14E-04 ! cell cycle arrest GO:0007050 150 86 5,000 1,036E-05 7,943E-04 ! positive regulation of cell migration GO:0030335 92 51 4,000 1,108E-05 8,223E-04 ! regulation of peptide secretion GO:0002791 34 25 3,000 1,209E-05 8,692E-04 ! positive regulation of glucose metabolic process GO:0010907 15 9 2,000 1,533E-05 1,069E-03 ! regulation of glycolysis GO:0006110 15 9 2,000 1,533E-05 1,037E-03 ! DNA damage response, signal transduction GO:0042770 96 56 4,000 1,762E-05 1,158E-03 ! positive regulation of cell motion GO:0051272 99 56 4,000 1,762E-05 1,125E-03 ! triglyceride metabolic process GO:0006641 34 28 3,000 1,931E-05 1,201E-03 ! negative regulation of kinase activity GO:0033673 100 58 4,000 2,094E-05 1,267E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 2,000 2,181E-05 1,286E-03 GO:0043470|regulation of carbohydrate catabolic process, ! activation of MAPK activity GO:0000187 84 59 4,000 2,277E-05 1,309E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 2,682E-05 1,504E-03 ! negative regulation of secretion GO:0051048 49 31 3,000 2,929E-05 1,604E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 2,986E-05 1,597E-03 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 2,000 2,986E-05 1,561E-03 ! neutral lipid metabolic process GO:0006638 41 32 3,000 3,333E-05 1,703E-03 GO:0006639|acylglycerol metabolic process, ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 3,965E-05 1,982E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 2,000 3,965E-05 1,94E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! glycerol ether metabolic process GO:0006662 44 34 3,000 4,26E-05 2,041E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 4,26E-05 2E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 5,133E-05 2,361E-03 ! regulation of hormone secretion GO:0046883 48 36 3,000 5,363E-05 2,419E-03 ! organic ether metabolic process GO:0018904 46 36 3,000 5,363E-05 2,372E-03 ! hormone-mediated signaling GO:0009755 49 36 3,000 5,363E-05 2,327E-03 ! axon cargo transport GO:0008088 27 14 2,000 6,505E-05 2,771E-03 ! gland development GO:0048732 148 77 4,000 8,279E-05 3,462E-03 ! regulation of glucose metabolic process GO:0010906 22 16 2,000 9,924E-05 4,076E-03 ! DNA replication initiation GO:0006270 25 16 2,000 9,924E-05 4,004E-03 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 2,000 9,924E-05 3,935E-03 ! regulation of gene-specific transcription GO:0032583 69 43 3,000 1,089E-04 4,246E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 1,089E-04 4,176E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 1,2E-04 4,525E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 1,2E-04 4,452E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 4,000 1,401E-04 5,113E-03 ! response to UV GO:0009411 75 46 3,000 1,421E-04 5,108E-03 ! interphase GO:0051325 159 88 4,000 1,561E-04 5,524E-03 ! regulation of DNA replication GO:0006275 75 48 3,000 1,68E-04 5,854E-03 ! regulation of carbohydrate metabolic process GO:0006109 28 19 2,000 1,696E-04 5,821E-03 GO:0010675|regulation of cellular carbohydrate metabolic process, ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 1,696E-04 5,736E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 1,696E-04 5,652E-03 ! microtubule-based transport GO:0010970 37 20 2,000 1,987E-04 6,527E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,987E-04 6,435E-03 ! positive regulation of secretion GO:0051047 71 51 3,000 2,129E-04 6,801E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 2,129E-04 6,708E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 2,308E-04 7,173E-03 ! cellular response to extracellular stimulus GO:0031668 32 21 2,000 2,308E-04 7,078E-03 ! protein import into nucleus, translocation GO:0000060 36 22 2,000 2,661E-04 8,054E-03 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 2,661E-04 7,949E-03 ! protein tetramerization GO:0051262 39 22 2,000 2,661E-04 7,847E-03 ! myelination GO:0042552 35 23 2,000 3,048E-04 8,873E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 3,048E-04 8,762E-03 ! negative regulation of DNA replication GO:0008156 35 23 2,000 3,048E-04 8,654E-03 ! cellular response to oxidative stress GO:0034599 33 23 2,000 3,048E-04 8,548E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 3,268E-04 9,055E-03 ! regulation of hormone biosynthetic process GO:0046885 7 5 1,000 3,268E-04 8,947E-03 ! forebrain regionalization GO:0021871 6 5 1,000 3,268E-04 8,842E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 3,268E-04 8,739E-03 ! cerebral cortex radially oriented cell migration GO:0021799 8 5 1,000 3,268E-04 8,639E-03 ! embryonic hemopoiesis GO:0035162 10 5 1,000 3,268E-04 8,54E-03 ! skeletal myofibril assembly GO:0014866 7 5 1,000 3,268E-04 8,445E-03 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 3,268E-04 8,351E-03 ! positive regulation of chemokine production GO:0032722 7 5 1,000 3,268E-04 8,259E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 3,268E-04 8,169E-03 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 3,268E-04 8,081E-03 GO:0007439|ectodermal gut development, ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 3,268E-04 7,995E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 3,268E-04 7,911E-03 GO:0022011|myelination in the peripheral nervous system, ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 3,277E-04 7,852E-03 ! multicellular organism reproduction GO:0032504 83 57 3,000 3,277E-04 7,771E-03 GO:0048609|reproductive process in a multicellular organism, ! response to peptide hormone stimulus GO:0043434 84 57 3,000 3,277E-04 7,692E-03 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 3,468E-04 8,058E-03 ! regulation of endothelial cell proliferation GO:0001936 46 24 2,000 3,468E-04 7,977E-03 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 3,468E-04 7,898E-03 ! lung development GO:0030324 94 59 3,000 3,743E-04 8,44E-03 ! respiratory tube development GO:0030323 99 62 3,000 4,527E-04 0,01010978 ! regulation of helicase activity GO:0051095 11 6 1,000 4,883E-04 0,01079897 ! prostate gland development GO:0030850 9 6 1,000 4,883E-04 0,01069613 ! male meiosis GO:0007140 7 6 1,000 4,883E-04 0,01059522 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 4,883E-04 0,0104962 ! mRNA stabilization GO:0048255 15 6 1,000 4,883E-04 0,01039901 GO:0043489|RNA stabilization, ! spinal cord dorsal/ventral patterning GO:0021513 6 6 1,000 4,883E-04 0,01030361 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 4,883E-04 0,01020994 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 4,883E-04 0,01011796 ! male sex determination GO:0030238 9 6 1,000 4,883E-04 0,01002762 ! astrocyte development GO:0014002 14 6 1,000 4,883E-04 9,939E-03 ! eating behavior GO:0042755 6 6 1,000 4,883E-04 9,852E-03 ! gas homeostasis GO:0033483 11 6 1,000 4,883E-04 9,766E-03 ! Schwann cell development GO:0014044 14 6 1,000 4,883E-04 9,682E-03 ! protein deubiquitination GO:0016579 8 6 1,000 4,883E-04 9,599E-03 GO:0070646|protein modification by small protein removal, ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 4,883E-04 9,518E-03 ! respiratory system development GO:0060541 100 64 3,000 5,111E-04 9,879E-03 ! protein oligomerization GO:0051259 100 65 3,000 5,423E-04 0,01039323 ! cell junction assembly GO:0034329 56 28 2,000 5,521E-04 0,01049357 ! ensheathment of neurons GO:0007272 43 28 2,000 5,521E-04 0,01040756 GO:0008366|axon ensheathment, ! positive regulation of catabolic process GO:0009896 40 28 2,000 5,521E-04 0,01032294 ! placenta development GO:0001890 37 28 2,000 5,521E-04 0,01023969 ! cell-substrate adhesion GO:0031589 121 66 3,000 5,747E-04 0,01057447 ! telencephalon development GO:0021537 52 29 2,000 6,132E-04 0,01119293 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 6,81E-04 0,01233389 ! cerebral cortex cell migration GO:0021795 11 7 1,000 6,81E-04 0,01223753 ! T-helper 1 type immune response GO:0042088 11 7 1,000 6,81E-04 0,01214267 ! spinal cord patterning GO:0021511 7 7 1,000 6,81E-04 0,01204926 ! hemoglobin metabolic process GO:0020027 10 7 1,000 6,81E-04 0,01195728 ! protein heterooligomerization GO:0051291 10 7 1,000 6,81E-04 0,0118667 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 6,81E-04 0,01177747 ! B cell lineage commitment GO:0002326 17 7 1,000 6,81E-04 0,01168958 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 6,81E-04 0,01160299 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 6,81E-04 0,01151768 ! T cell lineage commitment GO:0002360 12 7 1,000 6,81E-04 0,01143361 ! response to tumor cell GO:0002347 12 7 1,000 6,81E-04 0,01135075 ! mammary gland development GO:0030879 57 31 2,000 7,48E-04 0,01237724 ! positive regulation of gene-specific transcription GO:0043193 47 31 2,000 7,48E-04 0,01228883 ! response to hypoxia GO:0001666 132 72 3,000 7,989E-04 0,01303238 ! mitotic sister chromatid segregation GO:0000070 45 32 2,000 8,219E-04 0,01331326 ! negative regulation of DNA metabolic process GO:0051053 48 32 2,000 8,219E-04 0,01322016 ! peripheral nervous system development GO:0007422 53 32 2,000 8,219E-04 0,01312835 ! negative regulation of transport GO:0051051 116 73 3,000 8,415E-04 0,01334858 ! response to oxygen levels GO:0070482 137 74 3,000 8,857E-04 0,01395311 ! sister chromatid segregation GO:0000819 46 33 2,000 9,004E-04 0,0140874 ! cell junction organization GO:0034330 63 33 2,000 9,004E-04 0,01399221 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 9,046E-04 0,01396423 ! cell proliferation in forebrain GO:0021846 10 8 1,000 9,046E-04 0,01387113 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 9,046E-04 0,01377927 ! induction of positive chemotaxis GO:0050930 14 8 1,000 9,046E-04 0,01368862 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 9,046E-04 0,01359915 ! smoothened signaling pathway GO:0007224 8 8 1,000 9,046E-04 0,01351084 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 9,046E-04 0,01342368 ! astrocyte differentiation GO:0048708 16 8 1,000 9,046E-04 0,01333763 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 9,046E-04 0,01325267 ! regulation of vascular permeability GO:0043114 12 8 1,000 9,046E-04 0,0131688 ! Schwann cell differentiation GO:0014037 17 8 1,000 9,046E-04 0,01308597 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 9,046E-04 0,01300419 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 9,046E-04 0,01292342 ! regulation of embryonic development GO:0045995 16 8 1,000 9,046E-04 0,01284364 ! negative regulation of DNA replication initiation GO:0032297 9 8 1,000 9,046E-04 0,01276485 GO:0000076|DNA replication checkpoint, ! negative regulation of growth GO:0045926 123 75 3,000 9,315E-04 0,01306382 ! embryonic organ development GO:0048568 45 34 2,000 9,834E-04 0,0137077 ! regulation of action potential in neuron GO:0019228 54 35 2,000 1,071E-03 0,01484028 ! regulation of developmental growth GO:0048638 13 9 1,000 1,159E-03 0,01595852 ! telencephalon cell migration GO:0022029 16 9 1,000 1,159E-03 0,01586353 ! lung alveolus development GO:0048286 17 9 1,000 1,159E-03 0,01576966 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,159E-03 0,0156769 ! ventral spinal cord development GO:0021517 11 9 1,000 1,159E-03 0,01558522 ! motor axon guidance GO:0008045 14 9 1,000 1,159E-03 0,01549461 ! regulation of hormone metabolic process GO:0032350 15 9 1,000 1,159E-03 0,01540504 ! regulation of DNA replication initiation GO:0030174 13 9 1,000 1,159E-03 0,01531651 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 1,159E-03 0,01522899 ! embryonic placenta development GO:0001892 12 9 1,000 1,159E-03 0,01514246 ! localization within membrane GO:0051668 15 9 1,000 1,159E-03 0,01505691 ! positive regulation of transcription factor activity GO:0051091 49 36 2,000 1,164E-03 0,01503498 GO:0090047|positive regulation of transcription regulator activity, ! tissue remodeling GO:0048771 62 36 2,000 1,164E-03 0,01495098 ! neural tube development GO:0021915 50 36 2,000 1,164E-03 0,01486792 ! negative regulation of muscle development GO:0048635 12 10 1,000 1,443E-03 0,01833591 ! neuron fate specification GO:0048665 11 10 1,000 1,443E-03 0,01823517 ! regulation of B cell proliferation GO:0030888 15 10 1,000 1,443E-03 0,01813552 ! blood vessel remodeling GO:0001974 21 10 1,000 1,443E-03 0,01803696 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,443E-03 0,01793946 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 1,443E-03 0,01784301 ! response to X-ray GO:0010165 16 10 1,000 1,443E-03 0,0177476 ! forebrain cell migration GO:0021885 17 10 1,000 1,443E-03 0,01765319 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 1,000 1,443E-03 0,01755979 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,443E-03 0,01746737 ! regulation of bone resorption GO:0045124 24 10 1,000 1,443E-03 0,01737592 ! cranial nerve development GO:0021545 12 10 1,000 1,443E-03 0,01728542 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 1,443E-03 0,01719586 ! embryonic gut development GO:0048566 11 10 1,000 1,443E-03 0,01710722 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 1,471E-03 0,01734776 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 1,485E-03 0,01742565 ! regulation of membrane potential GO:0042391 128 85 3,000 1,485E-03 0,0173372 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 1,583E-03 0,01839319 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 2,000 1,583E-03 0,01830076 ! positive regulation of protein transport GO:0051222 55 40 2,000 1,583E-03 0,01820926 ! skeletal muscle tissue development GO:0007519 123 87 3,000 1,618E-03 0,01851639 GO:0060538|skeletal muscle organ development, ! positive regulation of DNA binding GO:0043388 57 41 2,000 1,701E-03 0,01937124 ! virus-host interaction GO:0019048 17 11 1,000 1,757E-03 0,01990665 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 1,757E-03 0,01980906 GO:0050927|positive regulation of positive chemotaxis, ! focal adhesion formation GO:0048041 24 11 1,000 1,757E-03 0,01971243 ! regulation of intracellular pH GO:0051453 17 11 1,000 1,757E-03 0,01961674 ! regulation of vascular endothelial growth factor production GO:0010574 19 11 1,000 1,757E-03 0,01952198 ! regulation of leukocyte migration GO:0002685 24 11 1,000 1,757E-03 0,01942812 ! digestive tract morphogenesis GO:0048546 15 11 1,000 1,757E-03 0,01933516 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 1,757E-03 0,01924309 GO:0042130|negative regulation of T cell proliferation, ! hormone metabolic process GO:0042445 121 90 3,000 1,833E-03 0,0199831 ! positive regulation of binding GO:0051099 59 43 2,000 1,953E-03 0,02119045 ! DNA-dependent DNA replication GO:0006261 59 43 2,000 1,953E-03 0,02109096 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 1,953E-03 0,02099241 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 2,067E-03 0,02211588 ! regulation of action potential GO:0001508 71 44 2,000 2,087E-03 0,02222689 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 2,087E-03 0,02212446 ! heart looping GO:0001947 15 12 1,000 2,1E-03 0,02216064 ! cell-cell junction assembly GO:0007043 18 12 1,000 2,1E-03 0,02205945 ! histone acetylation GO:0016573 23 12 1,000 2,1E-03 0,02195918 ! peptidyl-lysine modification GO:0018205 18 12 1,000 2,1E-03 0,02185982 ! response to gamma radiation GO:0010332 20 12 1,000 2,1E-03 0,02176135 ! regulation of mRNA stability GO:0043488 27 12 1,000 2,1E-03 0,02166377 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 2,1E-03 0,02156706 ! positive regulation of cell cycle GO:0045787 77 45 2,000 2,227E-03 0,02276677 ! response to light stimulus GO:0009416 153 96 3,000 2,321E-03 0,02362464 ! cell redox homeostasis GO:0045454 63 46 2,000 2,373E-03 0,02404008 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 2,473E-03 0,02494704 ! regulation of chemokine production GO:0032642 17 13 1,000 2,473E-03 0,0248381 ! endocrine pancreas development GO:0031018 19 13 1,000 2,473E-03 0,0247301 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 2,473E-03 0,02462305 ! intermediate filament cytoskeleton organization GO:0045104 23 13 1,000 2,473E-03 0,02451691 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 2,473E-03 0,02441169 ! regulation of cellular pH GO:0030641 20 13 1,000 2,473E-03 0,02430737 ! regulation of RNA stability GO:0043487 28 13 1,000 2,473E-03 0,02420393 ! endocrine system development GO:0035270 83 47 2,000 2,524E-03 0,02459711 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 2,524E-03 0,02449332 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! heart morphogenesis GO:0003007 65 48 2,000 2,681E-03 0,02590821 ! regulation of angiogenesis GO:0045765 94 49 2,000 2,844E-03 0,0273681 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 2,844E-03 0,02725407 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2,874E-03 0,02743143 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 2,874E-03 0,02731808 ! limbic system development GO:0021761 25 14 1,000 2,874E-03 0,02720566 ! pituitary gland development GO:0021983 23 14 1,000 2,874E-03 0,02709416 ! cellular response to starvation GO:0009267 21 14 1,000 2,874E-03 0,02698357 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 2,874E-03 0,02687388 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 2,874E-03 0,02676508 ! G1/S transition checkpoint GO:0031575 33 14 1,000 2,874E-03 0,02665716 ! intermediate filament-based process GO:0045103 24 14 1,000 2,874E-03 0,0265501 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 2,874E-03 0,0264439 ! muscle maintenance GO:0046716 19 14 1,000 2,874E-03 0,02633855 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 2,874E-03 0,02623403 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 2,874E-03 0,02613034 ! skeletal muscle fiber development GO:0048741 73 50 2,000 3,013E-03 0,0272817 ! positive regulation of growth GO:0045927 67 50 2,000 3,013E-03 0,02717471 ! muscle fiber development GO:0048747 74 51 2,000 3,188E-03 0,02864079 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 3,304E-03 0,02956964 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 3,304E-03 0,02945503 ! lipid phosphorylation GO:0046834 23 15 1,000 3,304E-03 0,0293413 ! adult walking behavior GO:0007628 25 15 1,000 3,304E-03 0,02922845 ! cerebral cortex development GO:0021987 29 15 1,000 3,304E-03 0,02911646 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 3,304E-03 0,02900533 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 3,304E-03 0,02889504 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 3,304E-03 0,02878559 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 3,304E-03 0,02867697 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 3,304E-03 0,02856916 ! protein amino acid acetylation GO:0006473 28 16 1,000 3,762E-03 0,03240606 ! glial cell development GO:0021782 24 16 1,000 3,762E-03 0,03228514 ! cellular response to hydrogen peroxide GO:0070301 21 16 1,000 3,762E-03 0,03216512 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 1,000 3,762E-03 0,03204599 ! diencephalon development GO:0021536 25 16 1,000 3,762E-03 0,03192774 ! neural crest cell migration GO:0001755 24 16 1,000 3,762E-03 0,03181036 ! nerve development GO:0021675 18 16 1,000 3,762E-03 0,03169384 ! forelimb morphogenesis GO:0035136 19 17 1,000 4,248E-03 0,03565428 ! cell-substrate junction assembly GO:0007044 39 17 1,000 4,248E-03 0,03552463 ! actin filament bundle formation GO:0051017 26 17 1,000 4,248E-03 0,03539591 ! neuromuscular junction development GO:0007528 23 17 1,000 4,248E-03 0,03526813 ! peptidyl-serine modification GO:0018209 27 17 1,000 4,248E-03 0,03514127 ! cell-cell junction organization GO:0045216 25 17 1,000 4,248E-03 0,03501531 ! proximal/distal pattern formation GO:0009954 25 17 1,000 4,248E-03 0,03489026 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 4,248E-03 0,03476609 ! chromosome segregation GO:0007059 83 57 2,000 4,369E-03 0,03563036 ! positive regulation of DNA replication GO:0045740 29 18 1,000 4,761E-03 0,03868977 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 4,761E-03 0,03855354 ! pancreas development GO:0031016 26 18 1,000 4,761E-03 0,03841826 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 4,761E-03 0,03828393 ! somitogenesis GO:0001756 24 18 1,000 4,761E-03 0,03815054 ! cellular response to nutrient levels GO:0031669 27 18 1,000 4,761E-03 0,03801807 ! gut development GO:0048565 26 18 1,000 4,761E-03 0,03788652 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 4,761E-03 0,03775588 ! negative regulation of T cell activation GO:0050868 25 18 1,000 4,761E-03 0,03762613 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 4,761E-03 0,03749728 ! actin filament organization GO:0007015 95 59 2,000 4,813E-03 0,03778502 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 5,046E-03 0,03947403 GO:0035113|embryonic appendage morphogenesis, ! regulation of homeostatic process GO:0032844 105 60 2,000 5,046E-03 0,03934022 ! meiosis GO:0007126 96 61 2,000 5,285E-03 0,0410643 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 2,000 5,285E-03 0,04092604 ! urogenital system development GO:0001655 101 61 2,000 5,285E-03 0,0407887 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 5,301E-03 0,04077412 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 5,301E-03 0,04063821 ! response to starvation GO:0042594 30 19 1,000 5,301E-03 0,0405032 ! sex determination GO:0007530 29 19 1,000 5,301E-03 0,04036908 ! response to lipopolysaccharide GO:0032496 26 19 1,000 5,301E-03 0,04023585 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 5,301E-03 0,04010349 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 5,301E-03 0,03997201 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 5,301E-03 0,03984138 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 5,301E-03 0,0397116 ! negative regulation of cell growth GO:0030308 106 62 2,000 5,53E-03 0,04129915 ! meiotic cell cycle GO:0051321 97 62 2,000 5,53E-03 0,04116549 ! regulation of transcription factor activity GO:0051090 97 63 2,000 5,783E-03 0,04290579 GO:0090046|regulation of transcription regulator activity, ! hindlimb morphogenesis GO:0035137 32 20 1,000 5,868E-03 0,04339325 ! spinal cord development GO:0021510 31 20 1,000 5,868E-03 0,04325417 ! chromosome condensation GO:0030261 31 20 1,000 5,868E-03 0,04311598 ! pallium development GO:0021543 38 20 1,000 5,868E-03 0,04297866 ! positive regulation of locomotion GO:0040017 35 20 1,000 5,868E-03 0,04284222 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 1,000 5,868E-03 0,04270665 ! positive regulation of B cell activation GO:0050871 31 20 1,000 5,868E-03 0,04257193 ! camera-type eye morphogenesis GO:0048593 34 20 1,000 5,868E-03 0,04243805 ! negative regulation of cell size GO:0045792 108 64 2,000 6,042E-03 0,04356462 ! appendage morphogenesis GO:0035107 93 64 2,000 6,042E-03 0,04342848 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 94 65 2,000 6,308E-03 0,04520002 GO:0060173|limb development, ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 6,461E-03 0,04614901 ! protein amino acid acylation GO:0043543 37 21 1,000 6,461E-03 0,04600613 ! regulation of chemotaxis GO:0050920 36 21 1,000 6,461E-03 0,04586414 ! cell aging GO:0007569 32 21 1,000 6,461E-03 0,04572302 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 6,461E-03 0,04558276 ! platelet activation GO:0030168 28 21 1,000 6,461E-03 0,04544337 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 6,461E-03 0,04530482 ! acetyl-CoA catabolic process GO:0046356 31 21 1,000 6,461E-03 0,04516711 GO:0006099|tricarboxylic acid cycle, ! regulation of Rho protein signal transduction GO:0035023 111 66 2,000 6,581E-03 0,04587024 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 7,08E-03 0,0491987 ! vasculogenesis GO:0001570 33 22 1,000 7,08E-03 0,04905051 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 7,08E-03 0,04890322 ! ureteric bud development GO:0001657 32 22 1,000 7,08E-03 0,0487568 ! coenzyme catabolic process GO:0009109 33 22 1,000 7,08E-03 0,04861126 ! regulation of behavior GO:0050795 38 22 1,000 7,08E-03 0,04846658 ! neural tube closure GO:0001843 33 22 1,000 7,08E-03 0,04832276 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! response to drug GO:0042493 108 69 2,000 7,442E-03 0,05064309 ! neuron fate commitment GO:0048663 32 23 1,000 7,726E-03 0,05241577 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 7,726E-03 0,0522616 ! acetyl-CoA metabolic process GO:0006084 33 23 1,000 7,726E-03 0,05210834 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 7,726E-03 0,05195598 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 7,726E-03 0,0518045 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 7,726E-03 0,05165391 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 7,726E-03 0,05150419 ! hydrogen peroxide metabolic process GO:0042743 30 23 1,000 7,726E-03 0,05135533 ! interaction with host GO:0051701 37 23 1,000 7,726E-03 0,05120733 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 7,726E-03 0,05106018 ! response to molecule of bacterial origin GO:0002237 30 23 1,000 7,726E-03 0,05091388 ! liver development GO:0001889 40 23 1,000 7,726E-03 0,05076841 ! regulation of catabolic process GO:0009894 106 70 2,000 7,743E-03 0,05074027 ! mitochondrial membrane organization GO:0007006 39 24 1,000 8,396E-03 0,05486302 ! neural crest cell development GO:0014032 39 24 1,000 8,396E-03 0,0547076 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 1,000 8,396E-03 0,05455306 ! negative regulation of cell development GO:0010721 56 24 1,000 8,396E-03 0,05439939 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 8,396E-03 0,05424658 ! glutathione metabolic process GO:0006749 29 24 1,000 8,396E-03 0,05409463 ! tube morphogenesis GO:0035239 118 73 2,000 8,689E-03 0,05582601 ! mitochondrion organization GO:0007005 104 73 2,000 8,689E-03 0,05567051 ! protein import into nucleus GO:0006606 118 74 2,000 9,019E-03 0,0576225 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 9,092E-03 0,05792956 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 9,092E-03 0,05776953 GO:0045936|negative regulation of phosphate metabolic process, ! iron ion homeostasis GO:0055072 39 25 1,000 9,092E-03 0,05761039 ! regulation of chromosome organization GO:0033044 35 25 1,000 9,092E-03 0,05745212 ! positive regulation of nuclear division GO:0051785 39 25 1,000 9,092E-03 0,05729471 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 9,092E-03 0,05713817 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 9,092E-03 0,05698248 ! nuclear import GO:0051170 121 75 2,000 9,356E-03 0,058476 ! regulation of cell morphogenesis GO:0022604 140 76 2,000 9,7E-03 0,06046339 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 9,813E-03 0,06100163 ! regulation of pH GO:0006885 36 26 1,000 9,813E-03 0,0608372 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 9,813E-03 0,06067366 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 9,813E-03 0,060511 ! regulation of DNA binding GO:0051101 119 77 2,000 0,01005201 0,06181719 ! myofibril assembly GO:0030239 36 27 1,000 0,01055877 0,06476046 GO:0055002|striated muscle cell development, ! response to ionizing radiation GO:0010212 47 27 1,000 0,01055877 0,06458823 ! cofactor catabolic process GO:0051187 45 27 1,000 0,01055877 0,06441691 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01055877 0,06424649 ! protein localization in nucleus GO:0034504 133 80 2,000 0,01115093 0,06767057 ! forebrain development GO:0030900 131 80 2,000 0,01115093 0,06749249 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,01132852 0,06838738 GO:0055092|sterol homeostasis, ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01132852 0,06820836 ! neural tube formation GO:0001841 41 28 1,000 0,01132852 0,06803027 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01132852 0,06785311 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,01212225 0,07241862 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,01212225 0,07223101 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,01212225 0,07204437 ! muscle cell development GO:0055001 38 29 1,000 0,01212225 0,07185869 ! eye morphogenesis GO:0048592 51 29 1,000 0,01212225 0,07167396 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,01272019 0,07501649 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,01293966 0,07611565 ! collagen metabolic process GO:0032963 40 30 1,000 0,01293966 0,07592148 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,01293966 0,0757283 ! spindle organization GO:0007051 37 30 1,000 0,01293966 0,07553609 ! adult locomotory behavior GO:0008344 47 30 1,000 0,01293966 0,07534486 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,01293966 0,0751546 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01293966 0,07496529 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01293966 0,07477694 ! anterior/posterior pattern formation GO:0009952 124 85 2,000 0,01313123 0,07569382 ! glial cell differentiation GO:0010001 55 31 1,000 0,01378046 0,07923767 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,01378046 0,07904007 ! odontogenesis GO:0042476 50 31 1,000 0,01378046 0,07884345 ! segmentation GO:0035282 41 31 1,000 0,01378046 0,07864781 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,01378046 0,07845314 ! metanephros development GO:0001656 58 31 1,000 0,01378046 0,07825943 ! cell fate specification GO:0001708 37 31 1,000 0,01378046 0,07806667 ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,01397594 0,07897952 ! regulation of muscle development GO:0048634 48 32 1,000 0,01464437 0,08255402 ! meiosis I GO:0007127 52 32 1,000 0,01464437 0,08235218 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,01464437 0,08215132 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,01464437 0,08195144 ! cytokine production GO:0001816 44 32 1,000 0,01464437 0,08175253 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01464437 0,08155458 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,01485092 0,08250514 ! reproductive developmental process GO:0003006 127 89 2,000 0,01485092 0,08230633 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,01553107 0,08586892 ! actomyosin structure organization GO:0031032 43 33 1,000 0,01553107 0,085663 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,01553107 0,08545807 ! lipid homeostasis GO:0055088 55 33 1,000 0,01553107 0,08525411 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,01553107 0,08505112 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,01553107 0,0848491 ! cytokinesis GO:0000910 52 33 1,000 0,01553107 0,08464804 ! cell fate commitment GO:0045165 141 92 2,000 0,01622044 0,08819625 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,01644031 0,0891809 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,01644031 0,08897107 ! feeding behavior GO:0007631 45 34 1,000 0,01644031 0,08876222 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,01644031 0,08855434 ! neuron migration GO:0001764 46 34 1,000 0,01644031 0,08834744 ! aerobic respiration GO:0009060 47 34 1,000 0,01644031 0,0881415 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,01644031 0,08793652 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,01644031 0,08773249 ! response to oxidative stress GO:0006979 141 94 2,000 0,01717163 0,09142304 ! glycogen metabolic process GO:0005977 48 35 1,000 0,01737177 0,09227501 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,01737177 0,0920624 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,01737177 0,09185076 ! regulation of binding GO:0051098 151 95 2,000 0,01765871 0,09315377 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,01815347 0,09554456 ! in utero embryonic development GO:0001701 147 96 2,000 0,01815347 0,09532642 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,01815347 0,09510928 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,0183252 0,09579081 ! glucan metabolic process GO:0044042 49 36 1,000 0,0183252 0,09557359 GO:0006073|cellular glucan metabolic process, ! protein import GO:0017038 156 99 2,000 0,01968382 0,10242714 ! protein localization in organelle GO:0033365 161 100 2,000 0,02020933 0,10492428 ! gliogenesis GO:0042063 71 38 1,000 0,02029679 0,10514105 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,02029679 0,10490478 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,02029679 0,10466957 ! mesenchymal cell development GO:0014031 64 38 1,000 0,02029679 0,10443541 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,02131442 0,10942669 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,02131442 0,10918298 ! JNK cascade GO:0007254 54 39 1,000 0,02131442 0,10894035 ! developmental growth GO:0048589 62 39 1,000 0,02131442 0,1086988 ! cell growth GO:0016049 61 39 1,000 0,02131442 0,10845831 ! synapse organization GO:0050808 55 39 1,000 0,02131442 0,10821889 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,02235289 0,11324151 ! peptide metabolic process GO:0006518 56 40 1,000 0,02235289 0,11299263 ! T cell differentiation GO:0030217 65 40 1,000 0,02235289 0,11274484 ! double-strand break repair GO:0006302 67 40 1,000 0,02235289 0,11249813 ! B cell differentiation GO:0030183 62 40 1,000 0,02235289 0,11225251 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,02235289 0,11200795 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,02341195 0,11705973 ! glucose transport GO:0015758 52 41 1,000 0,02341195 0,1168058 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,02341195 0,11655298 ! mitochondrial transport GO:0006839 60 42 1,000 0,02449132 0,12166313 ! hexose transport GO:0008645 54 42 1,000 0,02449132 0,12140092 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,02449132 0,12113985 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,02449132 0,12087989 ! regulation of cell shape GO:0008360 78 42 1,000 0,02449132 0,12062105 ! neuromuscular process GO:0050905 79 43 1,000 0,02559074 0,12576644 ! activation of caspase activity GO:0006919 65 43 1,000 0,02559074 0,12549828 ! regulation of cell projection organization GO:0031344 83 44 1,000 0,02670994 0,13070823 ! glycolysis GO:0006096 53 44 1,000 0,02670994 0,13043072 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,02670994 0,13015438 ! positive regulation of defense response GO:0031349 59 45 1,000 0,02784868 0,1354164 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,02784868 0,13513071 ! cell recognition GO:0008037 58 45 1,000 0,02784868 0,13484622 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02855823 0,13799143 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02855823 0,13770214 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02855823 0,13741406 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02855823 0,13712719 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02855823 0,13684151 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02855823 0,13655701 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02855823 0,1362737 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02855823 0,13599156 ! sleep GO:0030431 11 5 0,000 0,02855823 0,13571058 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02855823 0,13543077 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02855823 0,1351521 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02855823 0,13487458 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 6 5 0,000 0,02855823 0,1345982 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02855823 0,13432295 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02855823 0,13404882 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02855823 0,13377581 ! cobalt ion transport GO:0006824 9 5 0,000 0,02855823 0,13350391 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02855823 0,13323311 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02855823 0,13296341 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02855823 0,13269479 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02855823 0,13242726 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02855823 0,13216081 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02855823 0,13189543 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02855823 0,13163111 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02855823 0,13136785 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02855823 0,13110563 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02855823 0,13084447 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02855823 0,13058434 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02855823 0,13032524 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02855823 0,13006717 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02855823 0,12981012 ! malate metabolic process GO:0006108 7 5 0,000 0,02855823 0,12955409 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02855823 0,12929906 ! behavioral response to pain GO:0048266 7 5 0,000 0,02855823 0,12904503 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02855823 0,12879201 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02855823 0,12853997 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02855823 0,12828891 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! mating behavior GO:0007617 6 5 0,000 0,02855823 0,12803884 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,02855823 0,12778973 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02855823 0,1275416 ! rhythmic behavior GO:0007622 12 5 0,000 0,02855823 0,12729442 ! copulation GO:0007620 7 5 0,000 0,02855823 0,12704821 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02855823 0,12680294 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02855823 0,12655862 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02855823 0,12631524 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02855823 0,12607279 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02855823 0,12583127 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02855823 0,12559067 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02855823 0,125351 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02855823 0,12511223 ! response to protozoan GO:0001562 9 5 0,000 0,02855823 0,12487438 ! lymph vessel development GO:0001945 7 5 0,000 0,02855823 0,12463742 ! endochondral ossification GO:0001958 12 5 0,000 0,02855823 0,12440137 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02855823 0,12416621 ! parathyroid gland development GO:0060017 8 5 0,000 0,02855823 0,12393193 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02855823 0,12369854 ! anagen GO:0042640 6 5 0,000 0,02855823 0,12346602 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02855823 0,12323438 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02855823 0,1230036 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02855823 0,12277369 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,02855823 0,12254463 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02855823 0,12231643 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02855823 0,12208908 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02855823 0,12186257 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02855823 0,12163689 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02855823 0,12141206 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02855823 0,12118805 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02855823 0,12096487 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,02855823 0,12074251 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02855823 0,12052096 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02855823 0,12030022 ! ovulation GO:0030728 6 5 0,000 0,02855823 0,1200803 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02855823 0,11986117 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,02855823 0,11964285 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,02855823 0,11942531 ! response to pH GO:0009268 9 5 0,000 0,02855823 0,11920857 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02855823 0,11899261 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02855823 0,11877744 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02855823 0,11856304 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02855823 0,11834941 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02855823 0,11813655 ! polyol catabolic process GO:0046174 7 5 0,000 0,02855823 0,11792446 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02855823 0,11771312 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02855823 0,11750255 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02855823 0,11729272 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02855823 0,11708364 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02855823 0,11687531 ! urea metabolic process GO:0019627 6 5 0,000 0,02855823 0,11666771 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02855823 0,11646086 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02855823 0,11625473 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02855823 0,11604933 ! neutrophil activation GO:0042119 5 5 0,000 0,02855823 0,11584466 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02855823 0,11564071 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02855823 0,11543747 ! response to food GO:0032094 5 5 0,000 0,02855823 0,11523495 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02855823 0,11503314 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02855823 0,11483203 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02855823 0,11463163 ! forebrain neuron development GO:0021884 7 5 0,000 0,02855823 0,11443192 ! melanosome organization GO:0032438 7 5 0,000 0,02855823 0,11423291 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,02855823 0,11403459 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02855823 0,11383695 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02855823 0,11364 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02855823 0,11344374 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02855823 0,11324814 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02855823 0,11305322 ! nucleoside transport GO:0015858 6 5 0,000 0,02855823 0,11285897 ! nucleoside salvage GO:0043174 7 5 0,000 0,02855823 0,11266539 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02855823 0,11247247 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02855823 0,11228021 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02855823 0,11208861 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02855823 0,11189765 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02855823 0,11170735 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,02855823 0,1115177 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,02855823 0,11132868 ! depyrimidination GO:0045008 8 5 0,000 0,02855823 0,11114031 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02855823 0,11095257 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02855823 0,11076547 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02855823 0,11057899 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02855823 0,11039315 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02855823 0,11020792 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02855823 0,11002332 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02855823 0,10983934 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02855823 0,10965596 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02855823 0,1094732 ! monocyte differentiation GO:0030224 8 5 0,000 0,02855823 0,10929105 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02855823 0,10910951 ! centrosome duplication GO:0051298 5 5 0,000 0,02855823 0,10892856 ! response to UV-C GO:0010225 6 5 0,000 0,02855823 0,10874822 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02855823 0,10856847 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02855823 0,10838931 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02855823 0,10821075 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02855823 0,10803277 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02855823 0,10785537 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02855823 0,10767856 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02855823 0,10750233 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02855823 0,10732667 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02855823 0,10715159 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02855823 0,10697707 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02855823 0,10680313 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02855823 0,10662974 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02855823 0,10645693 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02855823 0,10628466 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02855823 0,10611296 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02855823 0,10594181 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02855823 0,10577121 ! neural tube patterning GO:0021532 6 5 0,000 0,02855823 0,10560116 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02855823 0,10543166 ! histone demethylation GO:0016577 9 5 0,000 0,02855823 0,1052627 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02855823 0,10509428 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02855823 0,10492639 GO:0032374|regulation of cholesterol transport, ! enteric nervous system development GO:0048484 8 5 0,000 0,02855823 0,10475905 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02855823 0,10459223 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02855823 0,10442595 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02855823 0,10426019 ! transcription termination GO:0006353 8 5 0,000 0,02855823 0,10409496 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02855823 0,10393026 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,02855823 0,10376607 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,02855823 0,1036024 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02855823 0,10343925 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02855823 0,10327661 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02855823 0,10311448 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02855823 0,10295286 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02855823 0,10279174 ! apical protein localization GO:0045176 6 5 0,000 0,02855823 0,10263113 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02855823 0,10247102 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02855823 0,10231141 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02855823 0,10215229 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02855823 0,10199367 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02855823 0,10183554 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02855823 0,1016779 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02855823 0,10152075 ! glial cell migration GO:0008347 10 5 0,000 0,02855823 0,10136408 ! determination of adult lifespan GO:0008340 8 5 0,000 0,02855823 0,10120789 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02855823 0,10105219 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02855823 0,10089696 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02855823 0,10074221 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02855823 0,10058794 ! neural plate development GO:0001840 6 5 0,000 0,02855823 0,10043413 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02855823 0,1002808 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02855823 0,10012793 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02855823 0,09997553 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02855823 0,09982359 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02855823 0,09967211 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02855823 0,0995211 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02855823 0,09937053 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02855823 0,09922043 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02855823 0,09907077 ! spindle assembly GO:0051225 5 5 0,000 0,02855823 0,09892157 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02855823 0,09877282 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02855823 0,09862451 ! organ regeneration GO:0031100 7 5 0,000 0,02855823 0,09847665 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02855823 0,09832923 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02855823 0,09818225 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02855823 0,09803571 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02855823 0,0978896 GO:0055081|anion homeostasis, ! histone modification GO:0016570 68 46 1,000 0,02900668 0,09927881 ! covalent chromatin modification GO:0016569 75 47 1,000 0,03018369 0,10315377 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,03018369 0,10300073 ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,03018369 0,10284813 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,03137946 0,10676444 GO:0010952|positive regulation of peptidase activity, ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,03137946 0,10660674 ! nuclear export GO:0051168 69 48 1,000 0,03137946 0,1064495 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,03137946 0,10629273 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,03137946 0,10613642 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,03259374 0,11008165 ! cartilage development GO:0051216 70 49 1,000 0,03259374 0,10992024 ! lipid modification GO:0030258 73 50 1,000 0,03382628 0,11390987 ! tRNA transcription GO:0009304 11 6 0,000 0,03417221 0,11490656 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,03417221 0,11473882 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,03417221 0,11457156 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,03417221 0,11440479 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,03417221 0,1142385 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,03417221 0,1140727 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,03417221 0,11390737 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,03417221 0,11374253 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,03417221 0,11357816 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,03417221 0,11341427 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,03417221 0,11325085 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,03417221 0,1130879 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,03417221 0,11292541 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,03417221 0,1127634 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,03417221 0,11260185 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,03417221 0,11244076 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,03417221 0,11228013 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,03417221 0,11211996 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,03417221 0,11196024 ! neuron adhesion GO:0007158 9 6 0,000 0,03417221 0,11180098 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,03417221 0,11164217 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,03417221 0,11148381 ! signal peptide processing GO:0006465 8 6 0,000 0,03417221 0,1113259 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,03417221 0,11116844 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,03417221 0,11101142 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,03417221 0,11085485 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,03417221 0,11069872 ! opsonization GO:0008228 8 6 0,000 0,03417221 0,11054302 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,03417221 0,11038777 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,03417221 0,11023294 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,03417221 0,11007856 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,03417221 0,1099246 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,03417221 0,10977107 ! photoreceptor cell development GO:0042461 10 6 0,000 0,03417221 0,10961798 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,03417221 0,1094653 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,03417221 0,10931306 ! mechanosensory behavior GO:0007638 8 6 0,000 0,03417221 0,10916123 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,03417221 0,10900983 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,03417221 0,10885885 ! response to interferon-gamma GO:0034341 12 6 0,000 0,03417221 0,10870828 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,03417221 0,10855813 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,03417221 0,1084084 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,03417221 0,10825908 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,03417221 0,10811016 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,03417221 0,10796166 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,03417221 0,10781356 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,03417221 0,10766587 ! thymic T cell selection GO:0045061 12 6 0,000 0,03417221 0,10751859 ! protein lipoylation GO:0009249 10 6 0,000 0,03417221 0,10737171 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,03417221 0,10722522 ! pigment granule organization GO:0048753 11 6 0,000 0,03417221 0,10707914 ! drug transport GO:0015893 6 6 0,000 0,03417221 0,10693345 ! cysteine metabolic process GO:0006534 7 6 0,000 0,03417221 0,10678816 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,03417221 0,10664327 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,03417221 0,10649877 ! histidine metabolic process GO:0006547 6 6 0,000 0,03417221 0,10635465 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,03417221 0,10621093 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,03417221 0,1060676 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,03417221 0,10592465 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,03417221 0,10578208 ! adenohypophysis development GO:0021984 10 6 0,000 0,03417221 0,1056399 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,03417221 0,10549811 ! hyperosmotic response GO:0006972 8 6 0,000 0,03417221 0,10535669 ! microtubule nucleation GO:0007020 10 6 0,000 0,03417221 0,10521565 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,03417221 0,10507498 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,03417221 0,1049347 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,03417221 0,10479478 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,03417221 0,10465524 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,03417221 0,10451608 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,03417221 0,10437728 ! response to dietary excess GO:0002021 7 6 0,000 0,03417221 0,10423884 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,03417221 0,10410078 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,03417221 0,10396308 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,03417221 0,10382574 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,03417221 0,10368877 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,03417221 0,10355216 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,03417221 0,10341591 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,03417221 0,10328001 ! neuron apoptosis GO:0051402 8 6 0,000 0,03417221 0,10314447 ! organic alcohol transport GO:0015850 9 6 0,000 0,03417221 0,10300929 ! T cell mediated immunity GO:0002456 12 6 0,000 0,03417221 0,10287446 ! carnitine transport GO:0015879 8 6 0,000 0,03417221 0,10273999 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,03417221 0,10260586 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,03417221 0,10247208 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,03417221 0,10233866 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,03417221 0,10220558 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,03417221 0,10207284 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,03417221 0,10194045 ! parturition GO:0007567 12 6 0,000 0,03417221 0,10180841 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,03417221 0,1016767 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,03417221 0,10154533 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,03417221 0,10141431 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,03417221 0,10128362 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,03417221 0,10115327 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,03417221 0,10102325 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,03417221 0,10089357 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,03417221 0,10076422 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,03417221 0,1006352 ! macrophage differentiation GO:0030225 10 6 0,000 0,03417221 0,10050651 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,03417221 0,10037815 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,03417221 0,10025011 ! interaction with symbiont GO:0051702 8 6 0,000 0,03417221 0,10012241 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,03417221 0,09999502 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,03417221 0,09986797 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,03417221 0,09974123 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,03417221 0,09961481 ! response to copper ion GO:0046688 9 6 0,000 0,03417221 0,09948872 ! DNA topological change GO:0006265 8 6 0,000 0,03417221 0,09936294 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,03417221 0,09923749 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,03417221 0,09911234 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,03417221 0,09898752 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,03417221 0,098863 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,03417221 0,0987388 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,03417221 0,09861492 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,03417221 0,09849134 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,03417221 0,09836807 ! hair follicle maturation GO:0048820 7 6 0,000 0,03417221 0,09824511 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,03417221 0,09812246 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,03417221 0,09800011 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,03417221 0,09787807 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,03417221 0,09775633 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,03417221 0,09763489 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,03417221 0,09751376 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,03417221 0,09739292 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,03417221 0,09727239 ! histone ubiquitination GO:0016574 7 6 0,000 0,03417221 0,09715215 ! regulation of meiosis GO:0040020 10 6 0,000 0,03417221 0,09703221 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,03417221 0,09691256 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,03417221 0,09679321 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,03417221 0,09667416 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,03417221 0,09655539 ! membrane to membrane docking GO:0022614 12 6 0,000 0,03417221 0,09643692 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,03417221 0,09631874 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,03417221 0,09620084 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,03417221 0,09608324 ! receptor internalization GO:0031623 9 6 0,000 0,03417221 0,09596592 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,03417221 0,09584889 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,03417221 0,09573214 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,03417221 0,09561568 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,03417221 0,0954995 ! regulation of macrophage activation GO:0043030 11 6 0,000 0,03417221 0,0953836 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,03417221 0,09526799 ! axonal fasciculation GO:0007413 9 6 0,000 0,03417221 0,09515265 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,03417221 0,09503759 ! thiamin metabolic process GO:0006772 6 6 0,000 0,03417221 0,09492281 ! midbrain development GO:0030901 6 6 0,000 0,03417221 0,09480831 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,03417221 0,09469408 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,03417221 0,09458013 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,03417221 0,09446645 ! progesterone metabolic process GO:0042448 8 6 0,000 0,03417221 0,09435305 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,03417221 0,09423991 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,03417221 0,09412705 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,03417221 0,09401446 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,03417221 0,09390214 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,03417221 0,09379008 ! adult feeding behavior GO:0008343 6 6 0,000 0,03417221 0,09367829 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,03417221 0,09356677 ! blastocyst growth GO:0001832 15 6 0,000 0,03417221 0,09345552 ! pigment granule transport GO:0051904 12 6 0,000 0,03417221 0,09334452 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,03417221 0,09323379 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,03417221 0,09312333 ! catecholamine transport GO:0051937 7 6 0,000 0,03417221 0,09301312 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,03417221 0,09290318 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,03417221 0,09279349 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,03417221 0,09268407 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,03417221 0,0925749 ! protein prenylation GO:0018342 10 6 0,000 0,03417221 0,09246599 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,03417221 0,09235733 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,03417221 0,09224893 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,03417221 0,09214078 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,03417221 0,09203289 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,03507683 0,09435872 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,03507683 0,09424849 ! adult behavior GO:0030534 80 51 1,000 0,03507683 0,09413851 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,03634514 0,0974287 ! aging GO:0007568 79 52 1,000 0,03634514 0,09731528 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,03634514 0,09720212 ! establishment of organelle localization GO:0051656 85 52 1,000 0,03634514 0,09708923 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,03763098 0,10040749 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,03763098 0,10029114 ! kidney development GO:0001822 90 53 1,000 0,03763098 0,10017506 ! regulation of mitosis GO:0007088 84 54 1,000 0,0389341 0,1035242 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 1,000 0,0389341 0,10340466 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,0389341 0,10328539 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,0389341 0,1031664 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,0389341 0,10304768 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,03975407 0,10509698 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03975407 0,10497631 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03975407 0,10485593 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03975407 0,10473582 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03975407 0,10461598 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,03975407 0,10449642 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03975407 0,10437713 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03975407 0,10425812 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03975407 0,10413937 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03975407 0,1040209 ! reproductive behavior GO:0019098 12 7 0,000 0,03975407 0,10390269 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03975407 0,10378476 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,03975407 0,10366709 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03975407 0,10354968 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,03975407 0,10343254 ! oligopeptide transport GO:0006857 11 7 0,000 0,03975407 0,10331567 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03975407 0,10319906 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03975407 0,10308272 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03975407 0,10296663 ! RNA methylation GO:0001510 11 7 0,000 0,03975407 0,10285081 ! pericardium development GO:0060039 8 7 0,000 0,03975407 0,10273525 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03975407 0,10261994 ! fibril organization GO:0043206 13 7 0,000 0,03975407 0,1025049 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03975407 0,10239011 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03975407 0,10227558 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,03975407 0,10216131 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03975407 0,10204729 ! lipoprotein transport GO:0042953 9 7 0,000 0,03975407 0,10193352 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03975407 0,10182001 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03975407 0,10170675 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03975407 0,10159374 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03975407 0,10148099 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03975407 0,10136848 ! chemosensory behavior GO:0007635 9 7 0,000 0,03975407 0,10125622 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03975407 0,10114421 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03975407 0,10103245 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03975407 0,10092094 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03975407 0,10080967 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03975407 0,10069864 ! reflex GO:0060004 12 7 0,000 0,03975407 0,10058787 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03975407 0,10047733 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03975407 0,10036704 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03975407 0,10025698 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03975407 0,10014717 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03975407 0,1000376 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03975407 0,09992827 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03975407 0,09981918 ! adrenal gland development GO:0030325 17 7 0,000 0,03975407 0,09971033 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03975407 0,09960171 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03975407 0,09949333 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03975407 0,09938518 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03975407 0,09927727 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03975407 0,0991696 ! endosome organization GO:0007032 10 7 0,000 0,03975407 0,09906216 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03975407 0,09895495 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,03975407 0,09884797 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03975407 0,09874122 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03975407 0,0986347 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03975407 0,09852842 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03975407 0,09842236 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03975407 0,09831653 ! galactose metabolic process GO:0006012 10 7 0,000 0,03975407 0,09821092 ! vesicle fusion GO:0006906 15 7 0,000 0,03975407 0,09810555 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03975407 0,0980004 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03975407 0,09789547 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03975407 0,09779077 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,03975407 0,09768629 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03975407 0,09758204 ! retinol metabolic process GO:0042572 9 7 0,000 0,03975407 0,09747801 ! behavioral fear response GO:0001662 13 7 0,000 0,03975407 0,0973742 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,03975407 0,09727061 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03975407 0,09716724 ! rRNA modification GO:0000154 12 7 0,000 0,03975407 0,09706409 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03975407 0,09696116 ! response to UV-B GO:0010224 11 7 0,000 0,03975407 0,09685844 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03975407 0,09675595 ! intermediate filament organization GO:0045109 11 7 0,000 0,03975407 0,09665367 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03975407 0,0965516 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03975407 0,09644976 ! fibrinolysis GO:0042730 9 7 0,000 0,03975407 0,09634812 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03975407 0,0962467 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03975407 0,0961455 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03975407 0,09604451 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03975407 0,09594372 ! response to tropane GO:0014073 13 7 0,000 0,03975407 0,09584315 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03975407 0,0957428 ! melanosome localization GO:0032400 10 7 0,000 0,03975407 0,09564265 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03975407 0,09554271 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03975407 0,09544297 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03975407 0,09534345 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03975407 0,09524413 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03975407 0,09514503 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03975407 0,09504612 ! mast cell activation GO:0045576 9 7 0,000 0,03975407 0,09494742 ! multicellular organismal aging GO:0010259 11 7 0,000 0,03975407 0,09484893 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03975407 0,09475064 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03975407 0,09465256 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03975407 0,09455467 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,03975407 0,09445699 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03975407 0,09435951 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03975407 0,09426224 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03975407 0,09416516 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03975407 0,09406828 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03975407 0,0939716 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03975407 0,09387512 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03975407 0,09377884 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03975407 0,09368276 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03975407 0,09358687 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03975407 0,09349118 ! diuresis GO:0030146 12 7 0,000 0,03975407 0,09339568 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03975407 0,09330038 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03975407 0,09320527 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03975407 0,09311036 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03975407 0,09301564 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03975407 0,09292111 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03975407 0,09282677 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03975407 0,09273263 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03975407 0,09263867 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03975407 0,09254491 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03975407 0,09245133 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03975407 0,09235795 ! lymph node development GO:0048535 9 7 0,000 0,03975407 0,09226475 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03975407 0,09217174 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03975407 0,09207892 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03975407 0,09198629 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03975407 0,09189384 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03975407 0,09180158 ! ATP catabolic process GO:0006200 10 7 0,000 0,03975407 0,0917095 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03975407 0,0916176 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,03975407 0,0915259 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03975407 0,09143437 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03975407 0,09134303 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03975407 0,09125187 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03975407 0,09116089 ! muscle adaptation GO:0043500 12 7 0,000 0,03975407 0,09107009 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03975407 0,09097947 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03975407 0,09088904 ! retina homeostasis GO:0001895 9 7 0,000 0,03975407 0,09079878 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03975407 0,0907087 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03975407 0,0906188 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03975407 0,09052908 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03975407 0,09043953 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03975407 0,09035017 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03975407 0,09026098 ! carbohydrate transport GO:0008643 74 57 1,000 0,0429448 0,0974093 ! camera-type eye development GO:0043010 88 57 1,000 0,0429448 0,09731333 ! viral reproductive process GO:0022415 87 58 1,000 0,04431469 0,10031869 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,04431469 0,10022005 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,04530399 0,10235676 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,04530399 0,10225631 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,04530399 0,10215606 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,04530399 0,10205601 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,04530399 0,10195615 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,04530399 0,10185648 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,04530399 0,10175702 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,04530399 0,10165774 ! phosphate transport GO:0006817 10 8 0,000 0,04530399 0,10155866 ! N-glycan processing GO:0006491 12 8 0,000 0,04530399 0,10145977 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,04530399 0,10136107 ! UTP metabolic process GO:0046051 8 8 0,000 0,04530399 0,10126257 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,04530399 0,10116426 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,04530399 0,10106613 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,04530399 0,1009682 ! succinate metabolic process GO:0006105 14 8 0,000 0,04530399 0,10087046 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,04530399 0,1007729 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,04530399 0,10067554 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,04530399 0,10057836 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,04530399 0,10048137 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,04530399 0,10038457 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,04530399 0,10028795 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,04530399 0,10019152 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,04530399 0,10009528 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,04530399 0,09999922 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,04530399 0,09990334 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,04530399 0,09980765 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,04530399 0,09971214 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,04530399 0,09961681 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,04530399 0,09952167 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,04530399 0,0994267 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,04530399 0,09933192 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,04530399 0,09923732 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,04530399 0,0991429 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,04530399 0,09904865 ! melanin metabolic process GO:0006582 12 8 0,000 0,04530399 0,09895459 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,04530399 0,09886071 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,04530399 0,098767 ! macrophage activation GO:0042116 12 8 0,000 0,04530399 0,09867347 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,04530399 0,09858012 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,04530399 0,09848694 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,04530399 0,09839394 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,04530399 0,09830112 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,04530399 0,09820847 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,04530399 0,09811599 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,04530399 0,09802369 ! ruffle organization GO:0031529 11 8 0,000 0,04530399 0,09793156 ! osteoblast development GO:0002076 13 8 0,000 0,04530399 0,09783961 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,04530399 0,09774783 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,04530399 0,09765622 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,04530399 0,09756478 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,04530399 0,09747351 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,04530399 0,09738241 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,04530399 0,09729149 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,04530399 0,09720073 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,04530399 0,09711014 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,04530399 0,09701972 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,04530399 0,09692947 ! oligodendrocyte development GO:0014003 8 8 0,000 0,04530399 0,09683939 ! segment specification GO:0007379 10 8 0,000 0,04530399 0,09674947 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,04530399 0,09665973 ! cellular extravasation GO:0045123 11 8 0,000 0,04530399 0,09657014 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,04530399 0,09648073 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,04530399 0,09639147 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,04530399 0,09630239 ! snRNA metabolic process GO:0016073 10 8 0,000 0,04530399 0,09621347 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,04530399 0,09612471 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,04530399 0,09603611 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,04530399 0,09594768 ! nucleosome disassembly GO:0006337 12 8 0,000 0,04530399 0,09585941 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,04530399 0,09577131 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,04530399 0,09568336 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,04530399 0,09559558 ! icosanoid secretion GO:0032309 12 8 0,000 0,04530399 0,09550796 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,04530399 0,0954205 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,04530399 0,0953332 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,04530399 0,09524605 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,04530399 0,09515907 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,04530399 0,09507225 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,04530399 0,09498558 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,04530399 0,09489907 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,04530399 0,09481272 ! sterol catabolic process GO:0016127 9 8 0,000 0,04530399 0,09472653 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,04530399 0,09464049 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,04530399 0,09455461 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,04530399 0,09446889 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,04530399 0,09438332 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,04530399 0,0942979 ! prophase GO:0051324 11 8 0,000 0,04530399 0,09421264 ! S phase GO:0051320 8 8 0,000 0,04530399 0,09412754 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,04530399 0,09404258 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,04530399 0,09395779 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,04530399 0,09387314 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,04530399 0,09378864 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,04530399 0,0937043 ! hormone catabolic process GO:0042447 13 8 0,000 0,04530399 0,09362011 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,04530399 0,09353607 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,04530399 0,09345218 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,04530399 0,09336844 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,04530399 0,09328486 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,04530399 0,09320142 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,04530399 0,09311813 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,04530399 0,09303499 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,04530399 0,09295199 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,04530399 0,09286915 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,04530399 0,09278645 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,04530399 0,0927039 ! lamellipodium assembly GO:0030032 9 8 0,000 0,04530399 0,0926215 ! mitochondrion localization GO:0051646 12 8 0,000 0,04530399 0,09253924 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,0457007 0,09326673 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,0457007 0,09318405 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,04710259 0,09595745 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,04995313 0,10167452 ! organelle localization GO:0051640 96 62 1,000 0,04995313 0,10158462 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,05082215 0,10326055 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,05082215 0,10316942 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,05082215 0,10307844 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,05082215 0,10298762 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,05082215 0,10289696 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,05082215 0,10280646 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,05082215 0,10271612 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,05082215 0,10262594 ! GTP metabolic process GO:0046039 9 9 0,000 0,05082215 0,10253592 ! elastic fiber assembly GO:0048251 13 9 0,000 0,05082215 0,10244605 ! social behavior GO:0035176 14 9 0,000 0,05082215 0,10235635 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,05082215 0,1022668 ! artery development GO:0060840 19 9 0,000 0,05082215 0,1021774 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,05082215 0,10208816 ! response to pain GO:0048265 16 9 0,000 0,05082215 0,10199908 ! protein complex disassembly GO:0043241 17 9 0,000 0,05082215 0,10191015 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,05082215 0,10182138 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,05082215 0,10173277 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,05082215 0,1016443 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,05082215 0,10155599 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,05082215 0,10146784 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,05082215 0,10137983 ! protein targeting to ER GO:0045047 19 9 0,000 0,05082215 0,10129198 ! T cell selection GO:0045058 18 9 0,000 0,05082215 0,10120428 ! endoderm development GO:0007492 12 9 0,000 0,05082215 0,10111674 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,05082215 0,10102934 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,05082215 0,1009421 ! arginine catabolic process GO:0006527 10 9 0,000 0,05082215 0,100855 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,05082215 0,10076806 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,05082215 0,10068126 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,05082215 0,10059462 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,05082215 0,10050812 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,05082215 0,10042178 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,05082215 0,10033558 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,05082215 0,10024953 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,05082215 0,10016362 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,05082215 0,10007787 ! mannose metabolic process GO:0006013 9 9 0,000 0,05082215 0,09999226 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,05082215 0,09990679 ! receptor clustering GO:0043113 15 9 0,000 0,05082215 0,09982148 ! epithelial cell development GO:0002064 10 9 0,000 0,05082215 0,0997363 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,05082215 0,09965128 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,05082215 0,09956639 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,05082215 0,09948166 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,05082215 0,09939706 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,05082215 0,09931261 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,05082215 0,09922831 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,05082215 0,09914415 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,05082215 0,09906013 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,05082215 0,09897625 ! blastoderm segmentation GO:0007350 11 9 0,000 0,05082215 0,09889251 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,05082215 0,09880892 ! DNA ligation GO:0006266 14 9 0,000 0,05082215 0,09872546 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,05082215 0,09864215 ! response to amine stimulus GO:0014075 13 9 0,000 0,05082215 0,09855898 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,05082215 0,09847595 ! erythrocyte development GO:0048821 11 9 0,000 0,05082215 0,09839305 ! renal water homeostasis GO:0003091 14 9 0,000 0,05082215 0,0983103 ! postreplication repair GO:0006301 11 9 0,000 0,05082215 0,09822769 ! mRNA cleavage GO:0006379 13 9 0,000 0,05082215 0,09814521 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,05082215 0,09806288 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,05082215 0,09798068 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,05082215 0,09789862 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,05082215 0,09781669 ! acid secretion GO:0046717 14 9 0,000 0,05082215 0,09773491 ! musculoskeletal movement GO:0050881 11 9 0,000 0,05082215 0,09765326 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,05082215 0,09757174 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,05082215 0,09749036 ! purine base metabolic process GO:0006144 18 9 0,000 0,05082215 0,09740912 ! oocyte differentiation GO:0009994 12 9 0,000 0,05082215 0,09732802 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,05082215 0,09724704 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,05082215 0,09716621 ! spleen development GO:0048536 15 9 0,000 0,05082215 0,0970855 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,05082215 0,09700494 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,05082215 0,0969245 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,05082215 0,0968442 ! detection of calcium ion GO:0005513 13 9 0,000 0,05082215 0,09676403 ! blastocyst formation GO:0001825 12 9 0,000 0,05082215 0,09668399 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,05082215 0,09660409 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,05082215 0,09652432 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,05082215 0,09644468 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,05082215 0,09636517 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,05082215 0,09628579 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,05082215 0,09620654 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,05082215 0,09612742 ! prepulse inhibition GO:0060134 14 9 0,000 0,05082215 0,09604844 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,05082215 0,09596958 ! insulin secretion GO:0030073 17 9 0,000 0,05082215 0,09589085 ! sequestering of metal ion GO:0051238 11 9 0,000 0,05082215 0,09581225 ! response to nicotine GO:0035094 16 9 0,000 0,05082215 0,09573378 ! establishment of cell polarity GO:0030010 12 9 0,000 0,05082215 0,09565544 ! nucleus localization GO:0051647 15 9 0,000 0,05082215 0,09557723 ! regulation of synapse organization GO:0050807 12 9 0,000 0,05082215 0,09549914 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,05140133 0,09650863 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,05140133 0,09642991 ! viral reproduction GO:0016032 92 63 1,000 0,05140133 0,09635132 ! regulation of lipase activity GO:0060191 109 63 1,000 0,05140133 0,09627286 ! hexose catabolic process GO:0019320 82 64 1,000 0,05286453 0,09893281 ! adaptive immune response GO:0002250 94 64 1,000 0,05286453 0,09885238 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 1,000 0,05434251 0,10153352 ! regulation of caspase activity GO:0043281 97 65 1,000 0,05434251 0,10145111 ! B cell activation GO:0042113 104 65 1,000 0,05434251 0,10136883 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,05434251 0,10128668 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,05434251 0,10120467 ! axon guidance GO:0007411 99 66 1,000 0,05583504 0,10390016 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,05630873 0,10469691 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,05630873 0,10461234 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,05630873 0,10452791 ! thyroid gland development GO:0030878 19 10 0,000 0,05630873 0,10444361 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,05630873 0,10435945 ! synapsis GO:0007129 13 10 0,000 0,05630873 0,10427542 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,05630873 0,10419153 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,05630873 0,10410778 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,05630873 0,10402416 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,05630873 0,10394067 ! sulfate transport GO:0008272 12 10 0,000 0,05630873 0,10385732 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,05630873 0,1037741 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,05630873 0,10369101 ! androgen metabolic process GO:0008209 13 10 0,000 0,05630873 0,10360806 ! phospholipid efflux GO:0033700 16 10 0,000 0,05630873 0,10352524 ! hippocampus development GO:0021766 19 10 0,000 0,05630873 0,10344255 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,05630873 0,10336 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,05630873 0,10327757 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,05630873 0,10319528 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,05630873 0,10311312 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,05630873 0,10303109 ! pathogenesis GO:0009405 13 10 0,000 0,05630873 0,10294919 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,05630873 0,10286741 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,05630873 0,10278577 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,05630873 0,10270426 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,05630873 0,10262288 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,05630873 0,10254163 ! melanocyte differentiation GO:0030318 15 10 0,000 0,05630873 0,1024605 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,05630873 0,10237951 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,05630873 0,10229864 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,05630873 0,1022179 ! B cell proliferation GO:0042100 14 10 0,000 0,05630873 0,10213728 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,05630873 0,1020568 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,05630873 0,10197644 ! lipid digestion GO:0044241 15 10 0,000 0,05630873 0,1018962 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,05630873 0,1018161 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,05630873 0,10173612 ! UV protection GO:0009650 14 10 0,000 0,05630873 0,10165626 ! entry into host cell GO:0030260 20 10 0,000 0,05630873 0,10157653 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,05630873 0,10149692 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,05630873 0,10141744 ! negative regulation of ossification GO:0030279 19 10 0,000 0,05630873 0,10133809 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,05630873 0,10125885 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,05630873 0,10117975 ! regulation of organ growth GO:0046620 11 10 0,000 0,05630873 0,10110076 ! response to dsRNA GO:0043331 18 10 0,000 0,05630873 0,1010219 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,05630873 0,10094316 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,05630873 0,10086454 ! embryonic axis specification GO:0000578 12 10 0,000 0,05630873 0,10078605 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,05630873 0,10070768 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,05630873 0,10062943 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,05630873 0,1005513 ! fucose catabolic process GO:0019317 16 10 0,000 0,05630873 0,10047329 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,05630873 0,10039541 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,05630873 0,10031764 ! protein sumoylation GO:0016925 12 10 0,000 0,05630873 0,10024 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,05630873 0,10016247 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,05630873 0,10008507 ! zymogen activation GO:0031638 14 10 0,000 0,05630873 0,10000778 ! salivary gland development GO:0007431 22 10 0,000 0,05630873 0,09993061 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,05630873 0,09985357 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,05630873 0,09977664 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,05630873 0,09969983 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,05630873 0,09962313 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,05630873 0,09954656 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,05630873 0,0994701 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,05630873 0,09939376 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,05630873 0,09931754 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,05630873 0,09924144 ! detection of bacterium GO:0016045 10 10 0,000 0,05630873 0,09916545 ! activation of innate immune response GO:0002218 10 10 0,000 0,05630873 0,09908958 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,05630873 0,09901382 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,05630873 0,09893818 ! developmental induction GO:0031128 13 10 0,000 0,05630873 0,09886265 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,05630873 0,09878724 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,05630873 0,09871195 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,05630873 0,09863677 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,05630873 0,0985617 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,05734192 0,10029386 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,05734192 0,10021765 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,06039788 0,10547846 ! rRNA transcription GO:0009303 17 11 0,000 0,0617639 0,10778223 ! respiratory burst GO:0045730 14 11 0,000 0,0617639 0,10770051 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,0617639 0,10761892 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,0617639 0,10753745 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,0617639 0,10745611 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,0617639 0,10737489 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,0617639 0,10729379 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,0617639 0,10721281 ! RNA polyadenylation GO:0043631 19 11 0,000 0,0617639 0,10713196 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,0617639 0,10705123 ! mating GO:0007618 14 11 0,000 0,0617639 0,10697062 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,0617639 0,10689013 ! T cell proliferation GO:0042098 20 11 0,000 0,0617639 0,10680976 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,0617639 0,10672951 ! bone resorption GO:0045453 16 11 0,000 0,0617639 0,10664938 ! regulated secretory pathway GO:0045055 14 11 0,000 0,0617639 0,10656938 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,0617639 0,10648949 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,0617639 0,10640972 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,0617639 0,10633007 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,0617639 0,10625054 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,0617639 0,10617113 ! syncytium formation GO:0006949 15 11 0,000 0,0617639 0,10609184 ! plasma membrane organization GO:0007009 18 11 0,000 0,0617639 0,10601267 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,0617639 0,10593361 ! mitotic spindle organization GO:0007052 15 11 0,000 0,0617639 0,10585468 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,0617639 0,10577586 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,0617639 0,10569716 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,0617639 0,10561857 ! adult heart development GO:0007512 11 11 0,000 0,0617639 0,1055401 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,0617639 0,10546175 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,0617639 0,10538351 ! temperature homeostasis GO:0001659 16 11 0,000 0,0617639 0,10530539 ! L-glutamate transport GO:0015813 16 11 0,000 0,0617639 0,10522739 GO:0015800|acidic amino acid transport, ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,0617639 0,1051495 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,0617639 0,10507173 ! stem cell development GO:0048864 29 11 0,000 0,0617639 0,10499407 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,0617639 0,10491653 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,0617639 0,1048391 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,0617639 0,10476178 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,0617639 0,10468458 ! vasoconstriction GO:0042310 15 11 0,000 0,0617639 0,10460749 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,0617639 0,10453052 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,0617639 0,10445366 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,0617639 0,10437691 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,0617639 0,10430028 ! ribosome assembly GO:0042255 13 11 0,000 0,0617639 0,10422375 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,0617639 0,10414734 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,0617639 0,10407105 ! chromatin silencing GO:0006342 19 11 0,000 0,0617639 0,10399486 ! nucleosome positioning GO:0016584 13 11 0,000 0,0617639 0,10391878 ! T cell homeostasis GO:0043029 20 11 0,000 0,0617639 0,10384282 ! regulation of isotype switching GO:0045191 19 11 0,000 0,0617639 0,10376697 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,0617639 0,10369122 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,0617639 0,10361559 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,0617639 0,10354007 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,0617639 0,10346466 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,0617639 0,10338936 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,0617639 0,10331417 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,0617639 0,10323908 ! male genitalia development GO:0030539 13 11 0,000 0,0617639 0,10316411 ! cholesterol efflux GO:0033344 19 11 0,000 0,0617639 0,10308924 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,0617639 0,10301449 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,0617639 0,10293984 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,0617639 0,1028653 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,0617639 0,10279087 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,0617639 0,10271654 ! defense response to fungus GO:0050832 12 11 0,000 0,0617639 0,10264232 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,0617639 0,10256821 ! lysogeny GO:0030069 18 11 0,000 0,0617639 0,10249421 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,0617639 0,10242032 ! acrosome reaction GO:0007340 13 11 0,000 0,0617639 0,10234653 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,0617639 0,10227284 ! eye development GO:0001654 111 70 1,000 0,06194655 0,10250148 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,06194655 0,10242779 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,06350872 0,10493538 ! muscle cell differentiation GO:0042692 104 71 1,000 0,06350872 0,10486005 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,06350872 0,10478483 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,06350872 0,10470971 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,06350872 0,10463471 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,0650842 0,10715365 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,0650842 0,10707701 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,0650842 0,10700047 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,06667278 0,10953386 ! lactation GO:0007595 20 12 0,000 0,06718785 0,11030126 ! reproductive cellular process GO:0048610 14 12 0,000 0,06718785 0,11022259 ! tRNA modification GO:0006400 14 12 0,000 0,06718785 0,11014402 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,06718785 0,11006557 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,06718785 0,10998723 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,06718785 0,10990901 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,06718785 0,10983089 ! non-recombinational repair GO:0000726 19 12 0,000 0,06718785 0,10975289 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,06718785 0,10967499 ! peroxisomal transport GO:0043574 21 12 0,000 0,06718785 0,10959721 ! cartilage condensation GO:0001502 18 12 0,000 0,06718785 0,10951954 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,06718785 0,10944197 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,06718785 0,10936452 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,06718785 0,10928717 ! palate development GO:0060021 15 12 0,000 0,06718785 0,10920994 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,06718785 0,10913281 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,06718785 0,1090558 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,06718785 0,10897889 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,06718785 0,10890209 ! arginine metabolic process GO:0006525 13 12 0,000 0,06718785 0,1088254 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,06718785 0,10874881 ! methionine metabolic process GO:0006555 13 12 0,000 0,06718785 0,10867234 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,06718785 0,10859597 ! Golgi organization GO:0007030 18 12 0,000 0,06718785 0,10851971 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,06718785 0,10844355 ! monoamine transport GO:0015844 13 12 0,000 0,06718785 0,10836751 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,06718785 0,10829157 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,06718785 0,10821573 ! L-amino acid transport GO:0015807 20 12 0,000 0,06718785 0,10814 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,06718785 0,10806438 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,06718785 0,10798886 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,06718785 0,10791345 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,06718785 0,10783815 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,06718785 0,10776295 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,06718785 0,10768785 ! cerebellum development GO:0021549 13 12 0,000 0,06718785 0,10761286 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,06718785 0,10753797 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,06718785 0,10746319 ! histone methylation GO:0016571 15 12 0,000 0,06718785 0,10738851 ! autonomic nervous system development GO:0048483 23 12 0,000 0,06718785 0,10731393 ! gland morphogenesis GO:0022612 23 12 0,000 0,06718785 0,10723946 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,06718785 0,10716509 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,06718785 0,10709083 ! regulation of epidermis development GO:0045682 17 12 0,000 0,06718785 0,10701667 ! intestinal absorption GO:0050892 19 12 0,000 0,06718785 0,10694261 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,06718785 0,10686865 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,06718785 0,10679479 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,06718785 0,10672104 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,06718785 0,10664739 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,06718785 0,10657384 ! microspike assembly GO:0030035 23 12 0,000 0,06718785 0,10650039 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,06718785 0,10642704 ! response to cold GO:0009409 14 12 0,000 0,06718785 0,1063538 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,06827427 0,10799919 ! blood coagulation GO:0007596 116 75 1,000 0,06988847 0,11047661 GO:0050817|coagulation, ! regulation of ligase activity GO:0051340 114 75 1,000 0,06988847 0,11040074 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,07258076 0,11457498 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,07258076 0,11449639 ! cGMP metabolic process GO:0046068 16 13 0,000 0,07258076 0,11441792 GO:0006182|cGMP biosynthetic process, ! water transport GO:0006833 17 13 0,000 0,07258076 0,11433955 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,07258076 0,11426129 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,07258076 0,11418313 ! lipid localization GO:0010876 24 13 0,000 0,07258076 0,11410509 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,07258076 0,11402715 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,07258076 0,11394931 ! organelle fusion GO:0048284 28 13 0,000 0,07258076 0,11387158 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,07258076 0,11379396 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,07258076 0,11371645 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,07258076 0,11363904 ! response to hexose stimulus GO:0009746 19 13 0,000 0,07258076 0,11356173 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,07258076 0,11348453 ! glutamate metabolic process GO:0006536 18 13 0,000 0,07258076 0,11340743 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,07258076 0,11333044 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,07258076 0,11325356 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,07258076 0,11317677 ! NAD metabolic process GO:0019674 21 13 0,000 0,07258076 0,1131001 ! exocrine system development GO:0035272 27 13 0,000 0,07258076 0,11302352 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,07258076 0,11294705 ! bone mineralization GO:0030282 15 13 0,000 0,07258076 0,11287068 ! regulation of exocytosis GO:0017157 17 13 0,000 0,07258076 0,11279442 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,07258076 0,11271826 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,07258076 0,1126422 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,07258076 0,11256625 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,07258076 0,11249039 ! genitalia development GO:0048806 15 13 0,000 0,07258076 0,11241464 ! cellular pigmentation GO:0033059 24 13 0,000 0,07258076 0,11233899 ! tissue regeneration GO:0042246 21 13 0,000 0,07258076 0,11226345 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,07258076 0,112188 ! cofactor transport GO:0051181 19 13 0,000 0,07258076 0,11211265 ! NADP metabolic process GO:0006739 18 13 0,000 0,07258076 0,11203741 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,07258076 0,11196227 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,07258076 0,11188723 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,07258076 0,11181229 ! gas transport GO:0015669 18 13 0,000 0,07258076 0,11173745 ! heme biosynthetic process GO:0006783 20 13 0,000 0,07258076 0,1116627 ! regulation of axon extension GO:0030516 23 13 0,000 0,07258076 0,11158806 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,07258076 0,11151352 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,07258076 0,11143908 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,07258076 0,11136474 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,07258076 0,1112905 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,07258076 0,11121635 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,07258076 0,11114231 ! sex differentiation GO:0007548 105 77 1,000 0,07315419 0,11194586 ! cellular respiration GO:0045333 107 79 1,000 0,07646839 0,1169397 ! T cell activation GO:0042110 134 79 1,000 0,07646839 0,116862 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,07794279 0,11903613 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,07794279 0,11895715 ! superoxide anion generation GO:0042554 18 14 0,000 0,07794279 0,11887826 ! neuron maturation GO:0042551 21 14 0,000 0,07794279 0,11879948 ! regulation of S phase GO:0033261 18 14 0,000 0,07794279 0,11872081 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,07794279 0,11864224 ! myotube differentiation GO:0014902 21 14 0,000 0,07794279 0,11856377 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,07794279 0,1184854 ! inositol metabolic process GO:0006020 20 14 0,000 0,07794279 0,11840715 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,07794279 0,11832899 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,07794279 0,11825094 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,07794279 0,11817298 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,07794279 0,11809514 ! gene silencing by RNA GO:0031047 20 14 0,000 0,07794279 0,11801739 ! response to cAMP GO:0051591 19 14 0,000 0,07794279 0,11793975 ! startle response GO:0001964 21 14 0,000 0,07794279 0,11786221 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,07794279 0,11778477 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,07794279 0,11770743 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,07794279 0,1176302 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,07794279 0,11755306 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,07794279 0,11747603 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,07794279 0,11739909 ! glycine metabolic process GO:0006544 22 14 0,000 0,07794279 0,11732226 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,07794279 0,11724553 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,07794279 0,1171689 ! regulation of heart rate GO:0002027 23 14 0,000 0,07794279 0,11709237 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,07794279 0,11701594 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,07794279 0,11693961 ! embryo implantation GO:0007566 27 14 0,000 0,07794279 0,11686338 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,07794279 0,11678724 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,07794279 0,11671121 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,07794279 0,11663527 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,07794279 0,11655944 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,07794279 0,1164837 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,07794279 0,11640806 ! mRNA splice site selection GO:0006376 26 14 0,000 0,07794279 0,11633252 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,07794279 0,11625708 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,07794279 0,11618174 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,07794279 0,11610649 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,07794279 0,11603134 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,07794279 0,11595629 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,07794279 0,11588133 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,07794279 0,11580647 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,07794279 0,11573171 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,07794279 0,11565704 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,07794279 0,11558247 ! cell killing GO:0001906 20 14 0,000 0,07794279 0,115508 ! cilium assembly GO:0042384 20 14 0,000 0,07794279 0,11543362 ! peptide hormone secretion GO:0030072 23 14 0,000 0,07794279 0,11535934 ! alcohol catabolic process GO:0046164 104 80 1,000 0,0781432 0,11558158 ! hemostasis GO:0007599 125 81 1,000 0,07982956 0,11799999 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,07982956 0,1179242 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,07982956 0,11784851 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,08152728 0,12027758 GO:0060348|bone development, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,08323619 0,12272002 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,08327413 0,1226973 ! positive regulation of cell size GO:0045793 20 15 0,000 0,08327413 0,12261875 ! metencephalon development GO:0022037 19 15 0,000 0,08327413 0,1225403 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,08327413 0,12246195 ! skin development GO:0043588 25 15 0,000 0,08327413 0,1223837 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,08327413 0,12230555 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,08327413 0,1222275 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,08327413 0,12214955 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,08327413 0,1220717 ! bile acid metabolic process GO:0008206 22 15 0,000 0,08327413 0,12199394 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,08327413 0,12191629 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,08327413 0,12183873 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,08327413 0,12176128 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,08327413 0,12168392 ! myoblast differentiation GO:0045445 27 15 0,000 0,08327413 0,12160666 ! centrosome cycle GO:0007098 16 15 0,000 0,08327413 0,1215295 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,08327413 0,12145244 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,08327413 0,12137547 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,08327413 0,1212986 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,08327413 0,12122183 ! response to osmotic stress GO:0006970 22 15 0,000 0,08327413 0,12114516 ! vesicle coating GO:0006901 25 15 0,000 0,08327413 0,12106858 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,08327413 0,1209921 ! DNA integration GO:0015074 22 15 0,000 0,08327413 0,12091571 ! peptide secretion GO:0002790 27 15 0,000 0,08327413 0,12083943 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,08327413 0,12076323 ! regulation of vasodilation GO:0042312 24 15 0,000 0,08327413 0,12068714 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,08327413 0,12061114 ! neuron recognition GO:0008038 22 15 0,000 0,08327413 0,12053524 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,08327413 0,12045943 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,08327413 0,12038371 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,08327413 0,1203081 ! biomineral formation GO:0031214 18 15 0,000 0,08327413 0,12023257 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,08327413 0,12015715 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,08327413 0,12008181 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,08327413 0,12000657 ! dopamine metabolic process GO:0042417 30 15 0,000 0,08327413 0,11993143 ! organic cation transport GO:0015695 19 15 0,000 0,08327413 0,11985638 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,08327413 0,11978142 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,08327413 0,11970656 ! defense response to virus GO:0051607 27 15 0,000 0,08327413 0,11963179 ! peptide hormone processing GO:0016486 19 15 0,000 0,08327413 0,11955711 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,08327413 0,11948253 ! regulation of defense response GO:0031347 117 84 1,000 0,08495609 0,12181983 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,08668681 0,12422409 ! protein secretion GO:0009306 27 16 0,000 0,08857494 0,12685079 ! hormone secretion GO:0046879 25 16 0,000 0,08857494 0,12677185 ! bone remodeling GO:0046849 24 16 0,000 0,08857494 0,12669301 ! endothelial cell migration GO:0043542 22 16 0,000 0,08857494 0,12661427 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,08857494 0,12653563 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,08857494 0,12645708 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,08857494 0,12637864 ! patterning of blood vessels GO:0001569 24 16 0,000 0,08857494 0,12630029 ! protein polyubiquitination GO:0000209 26 16 0,000 0,08857494 0,12622203 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,08857494 0,12614388 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,08857494 0,12606582 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,08857494 0,12598786 ! fructose metabolic process GO:0006000 20 16 0,000 0,08857494 0,12590999 ! regulation of protein binding GO:0043393 27 16 0,000 0,08857494 0,12583222 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,08857494 0,12575454 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,08857494 0,12567697 ! protein export from nucleus GO:0006611 24 16 0,000 0,08857494 0,12559948 ! negative regulation of immune response GO:0050777 28 16 0,000 0,08857494 0,1255221 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,08857494 0,1254448 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,08857494 0,12536761 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,08857494 0,12529051 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,08857494 0,1252135 ! oogenesis GO:0048477 23 16 0,000 0,08857494 0,12513659 ! G1 phase GO:0051318 27 16 0,000 0,08857494 0,12505977 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,08857494 0,12498304 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,08857494 0,12490641 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,08857494 0,12482988 ! steroid catabolic process GO:0006706 22 16 0,000 0,08857494 0,12475344 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,08857494 0,12467709 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,08857494 0,12460083 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,08857494 0,12452467 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,08857494 0,1244486 ! sperm-egg recognition GO:0035036 16 16 0,000 0,08857494 0,12437263 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,08857494 0,12429674 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,08857494 0,12422095 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,08857494 0,12414525 ! negative regulation of translation GO:0017148 22 16 0,000 0,08857494 0,12406965 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,09194208 0,12870772 ! regulation of T cell activation GO:0050863 128 89 1,000 0,09371429 0,1311088 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,0938454 0,13121242 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,0938454 0,1311327 ! negative regulation of defense response GO:0031348 19 17 0,000 0,0938454 0,13105308 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,0938454 0,13097356 ! glycerol metabolic process GO:0006071 20 17 0,000 0,0938454 0,13089414 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,0938454 0,13081481 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,0938454 0,13073557 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,0938454 0,13065643 ! signal complex assembly GO:0007172 29 17 0,000 0,0938454 0,13057739 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,0938454 0,13049845 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,0938454 0,1304196 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,0938454 0,13034084 ! memory GO:0007613 25 17 0,000 0,0938454 0,13026218 ! keratinization GO:0031424 17 17 0,000 0,0938454 0,13018361 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,0938454 0,13010514 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,0938454 0,13002677 ! retinoid metabolic process GO:0001523 22 17 0,000 0,0938454 0,12994848 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,0938454 0,12987029 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,0938454 0,1297922 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,0938454 0,1297142 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,0938454 0,12963629 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,0938454 0,12955848 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,0938454 0,12948076 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,0938454 0,12940314 ! membrane budding GO:0006900 29 17 0,000 0,0938454 0,1293256 ! heme metabolic process GO:0042168 27 17 0,000 0,0938454 0,12924816 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,0938454 0,12917081 ! body fluid secretion GO:0007589 27 17 0,000 0,0938454 0,12909356 ! stem cell differentiation GO:0048863 36 17 0,000 0,0938454 0,1290164 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,0938454 0,12893933 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,0938454 0,12886235 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,0938454 0,12878546 ! sensory perception of pain GO:0019233 23 17 0,000 0,0938454 0,12870866 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,0938454 0,12863196 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,0938454 0,12855535 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,0938454 0,12847883 ! synaptogenesis GO:0007416 24 17 0,000 0,0938454 0,1284024 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,0938454 0,12832606 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,0938454 0,12824981 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,0938454 0,12817365 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,0938454 0,12809758 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,0938454 0,12802161 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,0938454 0,12794572 ! leukocyte differentiation GO:0002521 143 90 1,000 0,09549644 0,13011956 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,09549644 0,13004252 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,09908569 0,13485035 ! positive regulation of translation GO:0045727 28 18 0,000 0,09908569 0,1347706 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,09908569 0,13469095 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,09908569 0,13461139 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,09908569 0,13453193 ! cAMP metabolic process GO:0046058 33 18 0,000 0,09908569 0,13445256 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,09908569 0,13437328 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,09908569 0,1342941 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,09908569 0,13421501 ! axis specification GO:0009798 26 18 0,000 0,09908569 0,13413602 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,09908569 0,13405711 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,09908569 0,1339783 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,09908569 0,13389958 ! glutamine metabolic process GO:0006541 23 18 0,000 0,09908569 0,13382096 ! response to retinoic acid GO:0032526 25 18 0,000 0,09908569 0,13374242 ! pigmentation during development GO:0048066 31 18 0,000 0,09908569 0,13366398 ! central nervous system neuron development GO:0021954 30 18 0,000 0,09908569 0,13358563 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,09908569 0,13350738 ! fucose metabolic process GO:0006004 26 18 0,000 0,09908569 0,13342921 ! response to fungus GO:0009620 19 18 0,000 0,09908569 0,13335114 ! peptide cross-linking GO:0018149 31 18 0,000 0,09908569 0,13327315 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,09908569 0,13319526 ! heart process GO:0003015 27 18 0,000 0,09908569 0,13311746 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,09908569 0,13303975 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,09908569 0,13296213 ! visual learning GO:0008542 35 18 0,000 0,09908569 0,1328846 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,09908569 0,13280716 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,09908569 0,13272981 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,09908569 0,13265256 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,09908569 0,13257539 ! vitamin transport GO:0051180 24 18 0,000 0,09908569 0,13249831 ! hormone transport GO:0009914 27 18 0,000 0,09908569 0,13242132 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,09908569 0,13234442 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,09908569 0,13226761 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,09908569 0,13219089 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,09908569 0,13211426 ! cell-cell recognition GO:0009988 20 18 0,000 0,09908569 0,13203771 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,09908569 0,13196126 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,09908569 0,13188489 ! regulation of glucose import GO:0046324 21 18 0,000 0,09908569 0,13180861 GO:0010827|regulation of glucose transport, ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,09908986 0,13173797 ! sulfur metabolic process GO:0006790 118 92 1,000 0,09908986 0,13166186 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,1009008 0,13399067 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,1009008 0,13391335 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,1009008 0,13383612 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,10429597 0,13825979 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,10429597 0,13818015 ! positive regulation of ossification GO:0045778 30 19 0,000 0,10429597 0,1381006 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,10429597 0,13802114 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,10429597 0,13794177 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,10429597 0,13786249 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,10429597 0,13778331 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,10429597 0,13770421 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,10429597 0,13762521 ! regeneration GO:0031099 32 19 0,000 0,10429597 0,13754629 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,10429597 0,13746747 ! response to alkaloid GO:0043279 32 19 0,000 0,10429597 0,13738874 ! sensory perception of taste GO:0050909 23 19 0,000 0,10429597 0,1373101 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,10429597 0,13723154 ! smooth muscle contraction GO:0006939 36 19 0,000 0,10429597 0,13715308 ! peroxisome organization GO:0007031 29 19 0,000 0,10429597 0,13707471 ! digestive system process GO:0022600 30 19 0,000 0,10429597 0,13699642 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,10429597 0,13691823 ! response to vitamin A GO:0033189 26 19 0,000 0,10429597 0,13684012 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,10429597 0,13676211 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,10429597 0,13668418 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,10429597 0,13660634 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,10429597 0,13652859 ! plasma membrane fusion GO:0045026 23 19 0,000 0,10429597 0,13645093 ! cytolysis GO:0019835 20 19 0,000 0,10429597 0,13637336 ! renal system process GO:0003014 35 19 0,000 0,10429597 0,13629587 ! vasodilation GO:0042311 33 19 0,000 0,10429597 0,13621848 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,10429597 0,13614117 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,10429597 0,13606395 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,10429597 0,13598681 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,10429597 0,13590977 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,10429597 0,13583281 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,10429597 0,13575593 ! sarcomere organization GO:0045214 23 19 0,000 0,10429597 0,13567915 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,10429597 0,13560245 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,10429597 0,13552584 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,10429597 0,13544931 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,10429597 0,13537288 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,10429597 0,13529652 ! protein stabilization GO:0050821 26 19 0,000 0,10429597 0,13522026 ! angiogenesis GO:0001525 149 95 1,000 0,1045503 0,13547362 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,10947642 0,14177689 ! iron ion transport GO:0006826 37 20 0,000 0,10947642 0,14169711 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,10947642 0,14161741 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,10947642 0,14153781 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,10947642 0,14145829 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,10947642 0,14137887 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,10947642 0,14129953 ! response to ethanol GO:0045471 37 20 0,000 0,10947642 0,14122028 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,10947642 0,14114112 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,10947642 0,14106205 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,10947642 0,14098307 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,10947642 0,14090417 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,10947642 0,14082537 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,10947642 0,14074665 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,10947642 0,14066802 ! DNA modification GO:0006304 28 20 0,000 0,10947642 0,14058948 ! collagen fibril organization GO:0030199 45 20 0,000 0,10947642 0,14051103 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,10947642 0,14043266 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,10947642 0,14035438 ! collagen catabolic process GO:0030574 25 20 0,000 0,10947642 0,14027619 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,10947642 0,14019808 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,10947642 0,14012007 ! alditol metabolic process GO:0019400 24 20 0,000 0,10947642 0,14004214 ! actin filament-based movement GO:0030048 34 20 0,000 0,10947642 0,13996429 ! extracellular structure organization GO:0043062 156 99 1,000 0,11195521 0,14305388 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,11382758 0,14536559 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,11382758 0,14528492 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,11462719 0,14622438 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,11462719 0,14614332 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,11462719 0,14606235 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,11462719 0,14598148 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,11462719 0,14590069 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,11462719 0,14581999 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,11462719 0,14573939 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,11462719 0,14565887 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,11462719 0,14557844 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,11462719 0,1454981 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,11462719 0,14541784 ! vesicle docking GO:0048278 27 21 0,000 0,11462719 0,14533768 ! phototransduction GO:0007602 25 21 0,000 0,11462719 0,1452576 ! dendrite development GO:0016358 35 21 0,000 0,11462719 0,14517761 ! visual behavior GO:0007632 39 21 0,000 0,11462719 0,14509772 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,11462719 0,1450179 ! ovarian follicle development GO:0001541 30 21 0,000 0,11462719 0,14493818 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,11462719 0,14485854 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,11462719 0,14477899 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,11462719 0,14469953 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,11462719 0,14462016 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,11462719 0,14454087 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,11462719 0,14446167 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,11462719 0,14438256 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,11462719 0,14430353 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,11462719 0,14422459 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,11462719 0,14414573 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,11462719 0,14406697 ! fatty acid transport GO:0015908 30 21 0,000 0,11462719 0,14398828 ! immunoglobulin production GO:0002377 33 21 0,000 0,11462719 0,14390969 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,11462719 0,14383118 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,11462719 0,14375275 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,11462719 0,14367441 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,11462719 0,14359616 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,11462719 0,14351799 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,11462719 0,14343991 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,11462719 0,14336191 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,11462719 0,14328399 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,11462719 0,14320616 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,11462719 0,14312842 ! regulation of multi-organism process GO:0043900 32 21 0,000 0,11462719 0,14305076 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,11974847 0,14936089 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,11974847 0,14927994 ! viral genome replication GO:0019079 29 22 0,000 0,11974847 0,14919907 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,11974847 0,14911829 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,11974847 0,1490376 ! leukocyte adhesion GO:0007159 38 22 0,000 0,11974847 0,148957 ! molting cycle process GO:0022404 40 22 0,000 0,11974847 0,14887648 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,11974847 0,14879605 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,11974847 0,14871571 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,11974847 0,14863545 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,11974847 0,14855528 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,11974847 0,1484752 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,11974847 0,1483952 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,11974847 0,14831529 ! lysosome organization GO:0007040 37 22 0,000 0,11974847 0,14823546 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,11974847 0,14815572 GO:0051693|actin filament capping, ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,11974847 0,14807607 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,11974847 0,1479965 ! membrane depolarization GO:0051899 35 22 0,000 0,11974847 0,14791702 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,11974847 0,14783762 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,11974847 0,14775831 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,11974847 0,14767908 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,11974847 0,14759994 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,11974847 0,14752088 ! blastocyst development GO:0001824 37 22 0,000 0,11974847 0,14744191 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,11974847 0,14736302 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,12484042 0,15354704 ! embryonic pattern specification GO:0009880 31 23 0,000 0,12484042 0,15346498 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,12484042 0,153383 ! vesicle targeting GO:0006903 32 23 0,000 0,12484042 0,1533011 ! osteoblast differentiation GO:0001649 40 23 0,000 0,12484042 0,1532193 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,12484042 0,15313758 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,12484042 0,15305595 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,12484042 0,15297441 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,12484042 0,15289295 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,12484042 0,15281159 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,12484042 0,1527303 ! cell fate determination GO:0001709 45 23 0,000 0,12484042 0,15264911 ! pentose metabolic process GO:0019321 31 23 0,000 0,12484042 0,152568 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,12484042 0,15248697 ! spermatid development GO:0007286 33 23 0,000 0,12484042 0,15240603 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,12484042 0,15232518 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,12484042 0,15224442 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,12484042 0,15216374 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,12484042 0,15208314 ! telomere organization GO:0032200 32 23 0,000 0,12484042 0,15200263 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,12484042 0,15192221 ! regulation of amine transport GO:0051952 38 23 0,000 0,12484042 0,15184187 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,1299032 0,15791616 ! initiation of viral infection GO:0019059 42 24 0,000 0,1299032 0,15783274 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,1299032 0,1577494 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,1299032 0,15766616 ! superoxide metabolic process GO:0006801 32 24 0,000 0,1299032 0,157583 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,1299032 0,15749993 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,1299032 0,15741695 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,1299032 0,15733405 ! sperm motility GO:0030317 27 24 0,000 0,1299032 0,15725125 ! vacuole organization GO:0007033 39 24 0,000 0,1299032 0,15716853 ! receptor metabolic process GO:0043112 37 24 0,000 0,1299032 0,15708589 ! response to toxin GO:0009636 38 24 0,000 0,1299032 0,15700335 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,1299032 0,15692089 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,1299032 0,15683851 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,1299032 0,15675623 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,1299032 0,15667403 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,1299032 0,15659191 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,1299032 0,15650988 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,13493699 0,16248956 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,13493699 0,16240454 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,13493699 0,1623196 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,13493699 0,16223475 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,13493699 0,16214998 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,13493699 0,16206531 ! peptide transport GO:0015833 43 25 0,000 0,13493699 0,16198072 ! male gonad development GO:0008584 33 25 0,000 0,13493699 0,16189623 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,13493699 0,16181182 ! phospholipid transport GO:0015914 35 25 0,000 0,13493699 0,1617275 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,13493699 0,16164327 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,13493699 0,16155912 ! detection of light stimulus GO:0009583 30 25 0,000 0,13493699 0,16147506 ! leukocyte proliferation GO:0070661 39 25 0,000 0,13493699 0,16139109 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,13994193 0,16729025 ! translational initiation GO:0006413 43 26 0,000 0,13994193 0,16720335 ! circadian rhythm GO:0007623 42 26 0,000 0,13994193 0,16711654 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,13994193 0,16702981 ! post-embryonic development GO:0009791 42 26 0,000 0,13994193 0,16694318 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,13994193 0,16685663 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,13994193 0,16677018 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,13994193 0,16668382 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,13994193 0,16659754 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,13994193 0,16651135 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,13994193 0,16642526 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,13994193 0,16633925 ! regulation of coagulation GO:0050818 39 26 0,000 0,13994193 0,16625333 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,14491821 0,17207635 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,14491821 0,17198755 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,14491821 0,17189886 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,14491821 0,17181025 ! membrane docking GO:0022406 39 27 0,000 0,14491821 0,17172173 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,14491821 0,17163331 ! catechol metabolic process GO:0009712 43 27 0,000 0,14491821 0,17154497 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,14491821 0,17145673 ! acute-phase response GO:0006953 42 27 0,000 0,14491821 0,17136858 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,14491821 0,17128051 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,14491821 0,17119254 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,14491821 0,17110466 ! natural killer cell activation GO:0030101 35 27 0,000 0,14491821 0,17101687 ! lipid oxidation GO:0034440 38 27 0,000 0,14491821 0,17092917 GO:0019395|fatty acid oxidation, ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,14491821 0,17084156 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,14491821 0,17075404 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,14491821 0,17066661 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,14491821 0,17057926 ! gene silencing GO:0016458 41 27 0,000 0,14491821 0,17049201 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,14986598 0,17622277 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,14986598 0,17613273 ! phenol metabolic process GO:0018958 44 28 0,000 0,14986598 0,17604277 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,14986598 0,17595291 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,14986598 0,17586313 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,14986598 0,17577345 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,14986598 0,17568387 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,14986598 0,17559437 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,14986598 0,17550496 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,14986598 0,17541565 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,14986598 0,17532642 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,14986598 0,17523729 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,14986598 0,17514824 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,14986598 0,17505929 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,14986598 0,17497043 ! mesoderm formation GO:0001707 46 28 0,000 0,14986598 0,17488166 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,14986598 0,17479297 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,14986598 0,17470438 ! BMP signaling pathway GO:0030509 40 28 0,000 0,14986598 0,17461588 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,14986598 0,17452747 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,14986598 0,17443914 ! regulation of innate immune response GO:0045088 38 29 0,000 0,15478539 0,18007406 ! ovulation cycle process GO:0022602 41 29 0,000 0,15478539 0,17998302 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,15478539 0,17989207 ! protein targeting to membrane GO:0006612 53 29 0,000 0,15478539 0,17980122 ! mismatch repair GO:0006298 34 29 0,000 0,15478539 0,17971045 ! formation of primary germ layer GO:0001704 48 29 0,000 0,15478539 0,17961978 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,15478539 0,1795292 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,15478539 0,17943871 ! tissue homeostasis GO:0001894 42 29 0,000 0,15478539 0,17934832 GO:0048871|multicellular organismal homeostasis, ! organic anion transport GO:0015711 51 30 0,000 0,15967663 0,18492258 ! cholesterol transport GO:0030301 46 30 0,000 0,15967663 0,18482951 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,15967663 0,18473654 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,15967663 0,18464366 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,15967663 0,18455087 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,15967663 0,18445818 ! ceramide metabolic process GO:0006672 43 30 0,000 0,15967663 0,18436558 ! ovulation cycle GO:0042698 43 30 0,000 0,15967663 0,18427308 ! hindbrain development GO:0030902 45 30 0,000 0,15967663 0,18418066 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,15967663 0,18408834 ! response to heat GO:0009408 41 30 0,000 0,15967663 0,18399611 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,15967663 0,18390398 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,15967663 0,18381193 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,16453983 0,18931546 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,16453983 0,18922081 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,16453983 0,18912624 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,16453983 0,18903177 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,16453983 0,1889374 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,16453983 0,18884312 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,16453983 0,18874893 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,16453983 0,18865484 ! RNA modification GO:0009451 40 31 0,000 0,16453983 0,18856084 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,16937517 0,19400542 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,16937517 0,19390886 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,16937517 0,19381238 ! regulation of protein stability GO:0031647 48 32 0,000 0,16937517 0,19371601 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,16937517 0,19361973 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,16937517 0,19352354 ! vesicle localization GO:0051648 47 32 0,000 0,16937517 0,19342745 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,1741828 0,19881907 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,1741828 0,19872045 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,1741828 0,19862193 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,1741828 0,19852351 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,1741828 0,19842518 ! ear morphogenesis GO:0042471 42 33 0,000 0,1741828 0,19832695 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,1741828 0,19822881 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,1741828 0,19813078 ! nucleus organization GO:0006997 49 33 0,000 0,1741828 0,19803284 ! female gonad development GO:0008585 49 33 0,000 0,1741828 0,197935 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,1741828 0,19783725 ! positive regulation of cell development GO:0010720 54 33 0,000 0,1741828 0,1977396 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,1741828 0,19764205 ! regulation of proteolysis GO:0030162 50 33 0,000 0,1741828 0,19754459 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,1741828 0,19744723 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,1741828 0,19734997 ! mRNA catabolic process GO:0006402 48 34 0,000 0,17896287 0,20266598 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,17896287 0,20256624 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,17896287 0,20246661 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,17896287 0,20236706 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,17896287 0,20226762 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,17896287 0,20216828 ! female gamete generation GO:0007292 43 34 0,000 0,17896287 0,20206903 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,17896287 0,20196988 ! polyol metabolic process GO:0019751 44 34 0,000 0,17896287 0,20187082 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,18371555 0,20713028 ! Notch signaling pathway GO:0007219 56 35 0,000 0,18371555 0,20702879 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,18371555 0,20692741 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,18371555 0,20682612 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,18371555 0,20672494 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,18371555 0,20662385 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,18371555 0,20652286 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,18371555 0,20642197 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,18371555 0,20632118 ! pigment metabolic process GO:0042440 61 35 0,000 0,18371555 0,20622048 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,18844099 0,2114216 ! negative regulation of binding GO:0051100 58 36 0,000 0,18844099 0,21131852 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,18844099 0,21121554 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,18844099 0,21111265 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,18844099 0,21100987 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,19313934 0,21616569 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,19313934 0,21606055 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,19313934 0,21595551 ! learning GO:0007612 67 37 0,000 0,19313934 0,21585058 ! ion transmembrane transport GO:0034220 56 37 0,000 0,19313934 0,21574575 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,19313934 0,21564101 ! regulation of protein secretion GO:0050708 51 37 0,000 0,19313934 0,21553639 ! amino acid activation GO:0043038 52 37 0,000 0,19313934 0,21543186 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,19313934 0,21532743 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,19781076 0,22042866 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,19781076 0,22032192 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,19781076 0,22021527 ! phagocytosis GO:0006909 60 38 0,000 0,19781076 0,22010874 ! pigmentation GO:0043473 74 38 0,000 0,19781076 0,2200023 ! maintenance of location in cell GO:0051651 69 38 0,000 0,19781076 0,21989597 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,2024554 0,22495045 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,2024554 0,22484183 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,2024554 0,22473332 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,2024554 0,22462491 ! male sex differentiation GO:0046661 53 39 0,000 0,2024554 0,2245166 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,2024554 0,2244084 ! chromatin remodeling GO:0006338 68 39 0,000 0,2024554 0,2243003 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,2024554 0,22419231 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,20707342 0,22919579 ! response to calcium ion GO:0051592 58 40 0,000 0,20707342 0,22908555 ! regulation of tube size GO:0035150 60 40 0,000 0,20707342 0,22897541 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,20707342 0,22886538 ! inner ear development GO:0048839 57 40 0,000 0,20707342 0,22875546 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,20707342 0,22864564 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,20707342 0,22853592 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,20707342 0,22842631 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,21166495 0,23337938 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,21166495 0,23326756 ! endosome transport GO:0016197 71 41 0,000 0,21166495 0,23315584 ! striated muscle contraction GO:0006941 62 41 0,000 0,21166495 0,23304423 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,21166495 0,23293273 ! biopolymer methylation GO:0043414 62 41 0,000 0,21166495 0,23282133 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,21166495 0,23271004 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,21623017 0,23761557 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,21623017 0,23750209 ! cellular component disassembly GO:0022411 64 42 0,000 0,21623017 0,23738873 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,21623017 0,23727547 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,21623017 0,23716232 ! excretion GO:0007588 63 42 0,000 0,21623017 0,23704928 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,21623017 0,23693634 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,21623017 0,23682351 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,21623017 0,2367108 ! leukocyte migration GO:0050900 60 43 0,000 0,2207692 0,24156478 ! tRNA processing GO:0008033 49 43 0,000 0,2207692 0,24144991 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,2207692 0,24133515 ! vesicle organization GO:0016050 79 43 0,000 0,2207692 0,2412205 ! methylation GO:0032259 64 43 0,000 0,2207692 0,24110596 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,22528221 0,24591793 ! regulation of ion transport GO:0043269 57 44 0,000 0,22528221 0,24580127 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,22528221 0,24568472 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,22528221 0,24556828 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,22528221 0,24545195 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,22528221 0,24533574 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,22528221 0,24521963 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,22528221 0,24510363 ! RNA catabolic process GO:0006401 64 45 0,000 0,22976933 0,24986736 ! regulation of translational initiation GO:0006446 64 45 0,000 0,22976933 0,24974927 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,22976933 0,2496313 ! cell maturation GO:0048469 60 45 0,000 0,22976933 0,24951344 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,23423072 0,25423816 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,23423072 0,25411824 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,23423072 0,25399843 ! regulation of ossification GO:0030278 71 46 0,000 0,23423072 0,25387873 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,23423072 0,25375914 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,23866653 0,25844304 ! viral infectious cycle GO:0019058 71 47 0,000 0,23866653 0,25832142 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,23866653 0,25819991 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,23866653 0,25807852 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,23866653 0,25795724 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,23866653 0,25783608 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,23866653 0,25771503 ! chloride transport GO:0006821 67 48 0,000 0,24307689 0,26235422 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,24307689 0,26223117 ! response to temperature stimulus GO:0009266 62 48 0,000 0,24307689 0,26210823 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,24307689 0,2619854 ! gastrulation GO:0007369 73 48 0,000 0,24307689 0,26186269 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,24307689 0,2617401 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,24307689 0,26161762 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,24307689 0,26149525 ! regulation of endocytosis GO:0030100 63 48 0,000 0,24307689 0,261373 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,24746196 0,26596379 ! sensory perception of smell GO:0007608 61 49 0,000 0,24746196 0,26583956 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,24746196 0,26571545 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,24746196 0,26559146 ! RNA elongation GO:0006354 62 49 0,000 0,24746196 0,26546758 ! germ cell development GO:0007281 68 49 0,000 0,24746196 0,26534382 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,24746196 0,26522018 ! maintenance of location GO:0051235 84 49 0,000 0,24746196 0,26509665 ! regulation of actin filament length GO:0030832 72 50 0,000 0,25182187 0,26964167 ! ear development GO:0043583 72 50 0,000 0,25182187 0,26951619 ! membrane fusion GO:0006944 80 50 0,000 0,25182187 0,26939084 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,25182187 0,2692656 ! proton transport GO:0015992 75 50 0,000 0,25182187 0,26914047 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,25182187 0,26901547 ! hydrogen transport GO:0006818 77 51 0,000 0,25615677 0,2735193 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,25615677 0,27339238 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,25615677 0,27326557 ! transition metal ion transport GO:0000041 74 52 0,000 0,2604668 0,27773465 ! regulation of cellular component size GO:0032535 74 52 0,000 0,2604668 0,27760595 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,2604668 0,27747737 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,26475211 0,28191196 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,26475211 0,28178151 ! single fertilization GO:0007338 59 53 0,000 0,26475211 0,28165118 ! cell projection assembly GO:0030031 76 53 0,000 0,26475211 0,28152096 ! amino acid transport GO:0006865 84 54 0,000 0,26901282 0,28591936 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,26901282 0,28578729 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,26901282 0,28565535 ! DNA catabolic process GO:0006308 67 54 0,000 0,26901282 0,28552353 ! detection of external stimulus GO:0009581 66 54 0,000 0,26901282 0,28539183 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,26901282 0,28526025 ! exocytosis GO:0006887 74 55 0,000 0,27324909 0,28961885 ! mesoderm development GO:0007498 76 55 0,000 0,27324909 0,28948545 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,27324909 0,28935217 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,27324909 0,28921901 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,27746105 0,29354205 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,27746105 0,29340709 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,28164884 0,29769869 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,28164884 0,29756194 ! secondary metabolic process GO:0019748 84 57 0,000 0,28164884 0,29742532 ! developmental maturation GO:0021700 75 57 0,000 0,28164884 0,29728882 ! gonad development GO:0008406 79 57 0,000 0,28164884 0,29715245 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,2858126 0,30140714 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,2858126 0,30126901 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,28995246 0,30549274 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,29406856 0,30968759 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,29406856 0,30954585 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,29406856 0,30940425 ! regulation of heart contraction GO:0008016 91 60 0,000 0,29406856 0,30926278 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,29406856 0,30912143 ! fertilization GO:0009566 68 60 0,000 0,29406856 0,30898021 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,29816103 0,31313716 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,29816103 0,31299424 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,29816103 0,31285145 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,29816103 0,31270879 ! extracellular matrix organization GO:0030198 103 61 0,000 0,29816103 0,31256626 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,29816103 0,31242386 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,29816103 0,31228159 ! amine catabolic process GO:0009310 90 62 0,000 0,30223002 0,3163992 ! neurotransmitter transport GO:0006836 81 62 0,000 0,30223002 0,31625525 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,30223002 0,31611143 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,30223002 0,31596774 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,30627564 0,32005178 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,31029804 0,32410785 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,31029804 0,32396073 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,31029804 0,32381374 ! defense response to bacterium GO:0042742 73 65 0,000 0,31429734 0,3278385 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,31429734 0,32768989 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,31429734 0,32754141 ! activation of immune response GO:0002253 83 65 0,000 0,31429734 0,32739307 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,31827369 0,33138501 ! antigen processing and presentation GO:0019882 96 66 0,000 0,31827369 0,33123506 ! regulation of immune effector process GO:0002697 101 66 0,000 0,31827369 0,33108525 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,3222272 0,33504636 ! acute inflammatory response GO:0002526 92 68 0,000 0,32615801 0,33898031 ! learning or memory GO:0007611 123 68 0,000 0,32615801 0,3388272 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,32615801 0,33867423 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,32615801 0,3385214 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,32615801 0,33836871 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,32615801 0,33821615 ! rhythmic process GO:0048511 105 68 0,000 0,32615801 0,33806373 ! inorganic anion transport GO:0015698 93 68 0,000 0,32615801 0,33791145 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,33006625 0,34180656 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,33006625 0,34165273 ! response to metal ion GO:0010038 103 70 0,000 0,33395204 0,34551943 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,33395204 0,34536407 ! humoral immune response GO:0006959 86 70 0,000 0,33395204 0,34520885 ! amine transport GO:0015837 101 70 0,000 0,33395204 0,34505377 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,33395204 0,34489883 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,33781551 0,34873235 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,33781551 0,3485759 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,3416568 0,35238145 ! regulation of blood pressure GO:0008217 107 73 0,000 0,34547602 0,35616085 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,34547602 0,35600128 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,34927331 0,35975307 ! digestion GO:0007586 97 74 0,000 0,34927331 0,35959204 ! response to inorganic substance GO:0010035 115 75 0,000 0,35304878 0,36331642 ! response to nutrient GO:0007584 104 75 0,000 0,35304878 0,36315393 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,35304878 0,36299159 ! amine biosynthetic process GO:0009309 97 76 0,000 0,35680256 0,36668717 ! tRNA metabolic process GO:0006399 95 76 0,000 0,35680256 0,3665234 ! response to unfolded protein GO:0006986 99 76 0,000 0,35680256 0,36635977 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,36053477 0,37002677 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,36053477 0,36986172 ! protein ubiquitination GO:0016567 125 77 0,000 0,36053477 0,36969683 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,36053477 0,36953208 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,36053477 0,36936748 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,36053477 0,36920302 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,36424555 0,37283701 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,36424555 0,37267116 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,36424555 0,37250545 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,367935 0,37611133 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,367935 0,37594424 ! regulation of lyase activity GO:0051339 133 79 0,000 0,367935 0,37577731 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,367935 0,37561052 ! chromatin assembly GO:0031497 102 80 0,000 0,37160325 0,37918699 GO:0006334|nucleosome assembly, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,37160325 0,37901883 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,37160325 0,37885083 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,37525042 0,38239963 ! mRNA transport GO:0051028 121 81 0,000 0,37525042 0,38223028 ! response to protein stimulus GO:0051789 111 81 0,000 0,37525042 0,38206107 ! regulation of neurological system process GO:0031644 122 81 0,000 0,37525042 0,38189202 ! vitamin metabolic process GO:0006766 103 81 0,000 0,37525042 0,38172312 ! detection of stimulus GO:0051606 108 82 0,000 0,37887663 0,38524149 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,382482 0,38873557 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,382482 0,38856387 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,38606665 0,39203236 ! sterol metabolic process GO:0016125 120 84 0,000 0,38606665 0,39185936 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,3896307 0,39530243 ! rRNA metabolic process GO:0016072 107 85 0,000 0,3896307 0,39512813 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,3896307 0,39495399 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,39317426 0,39837039 ! nucleosome organization GO:0034728 114 87 0,000 0,39669745 0,40176316 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,39669745 0,40158632 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,39669745 0,40140965 ! female pregnancy GO:0007565 130 87 0,000 0,39669745 0,40123312 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,40020038 0,40459819 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,40020038 0,40442042 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,40020038 0,40424281 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,40020038 0,40406535 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,40368318 0,40740294 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,40368318 0,40722426 ! RNA localization GO:0006403 135 91 0,000 0,41058881 0,41400889 ! ATP metabolic process GO:0046034 137 91 0,000 0,41058881 0,41382746 ! response to virus GO:0009615 122 91 0,000 0,41058881 0,4136462 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,41401188 0,41691214 ! positive regulation of immune response GO:0050778 121 92 0,000 0,41401188 0,41672968 ! DNA recombination GO:0006310 146 92 0,000 0,41401188 0,41654738 ! electron transport chain GO:0022900 123 94 0,000 0,42079907 0,42319102 ! carboxylic acid transport GO:0046942 147 95 0,000 0,42416342 0,42638805 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,42750842 0,42956285 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,42750842 0,42937526 ! protein maturation GO:0051604 129 96 0,000 0,42750842 0,42918785 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,43083417 0,43233796 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,43083417 0,43214941 ! calcium ion transport GO:0006816 167 99 0,000 0,43742841 0,43857251 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,43742841 0,43838141 ! regulation of translation GO:0006417 151 100 0,000 0,44069711 0,44146487 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,44069711 0,44127268 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,44069711 0,44108066 ! divalent metal ion transport GO:0070838 171 100 0,000 0,44069711 0,4408888 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,44069711 0,44069711