pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6289-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 3,000 2,539E-07 5,84E-04 ! insulin receptor signaling pathway GO:0008286 40 24 4,000 1,074E-06 1,235E-03 ! cranial nerve morphogenesis GO:0021602 6 5 2,000 4,758E-06 3,648E-03 ! cellular response to insulin stimulus GO:0032869 52 34 4,000 6,597E-06 3,793E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 3,000 8,169E-06 3,758E-03 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 9,46E-06 3,626E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 2,000 9,46E-06 3,108E-03 ! ER overload response GO:0006983 7 6 2,000 9,46E-06 2,72E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 3,000 1,044E-05 2,668E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 3,000 1,633E-05 3,755E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,646E-05 3,442E-03 ! regulation of gene-specific transcription GO:0032583 69 43 4,000 2,156E-05 4,132E-03 ! response to insulin stimulus GO:0032868 63 43 4,000 2,156E-05 3,814E-03 ! epithelial tube morphogenesis GO:0060562 65 43 4,000 2,156E-05 3,542E-03 ! protein import into nucleus, translocation GO:0000060 36 22 3,000 2,435E-05 3,733E-03 ! protein import into nucleus GO:0006606 118 74 5,000 2,587E-05 3,719E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 2,618E-05 3,542E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,618E-05 3,346E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 4,000 2,702E-05 3,27E-03 ! nuclear import GO:0051170 121 75 5,000 2,794E-05 3,213E-03 ! protein localization in nucleus GO:0034504 133 80 5,000 4,037E-05 4,421E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 2,000 5,546E-05 5,798E-03 ! cranial nerve development GO:0021545 12 10 2,000 5,546E-05 5,546E-03 ! cell cycle arrest GO:0007050 150 86 5,000 6,076E-05 5,823E-03 ! positive regulation of catabolic process GO:0009896 40 28 3,000 6,569E-05 6,044E-03 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 2,000 7,582E-05 6,707E-03 ! response to peptide hormone stimulus GO:0043434 84 57 4,000 8,583E-05 7,311E-03 ! cell fate commitment GO:0045165 141 92 5,000 8,866E-05 7,283E-03 ! peptidyl-amino acid modification GO:0018193 147 93 5,000 9,417E-05 7,469E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 1,005E-04 7,705E-03 ! Golgi organization GO:0007030 18 12 2,000 1,005E-04 7,457E-03 ! histone acetylation GO:0016573 23 12 2,000 1,005E-04 7,224E-03 ! peptidyl-lysine modification GO:0018205 18 12 2,000 1,005E-04 7,005E-03 ! lung development GO:0030324 94 59 4,000 1,013E-04 6,855E-03 ! respiratory tube development GO:0030323 99 62 4,000 1,285E-04 8,446E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 2,000 1,299E-04 8,299E-03 ! intermediate filament cytoskeleton organization GO:0045104 23 13 2,000 1,299E-04 8,075E-03 ! regulation of monooxygenase activity GO:0032768 26 13 2,000 1,299E-04 7,862E-03 ! protein import GO:0017038 156 99 5,000 1,332E-04 7,854E-03 ! protein localization in organelle GO:0033365 161 100 5,000 1,408E-04 8,095E-03 ! respiratory system development GO:0060541 100 64 4,000 1,495E-04 8,388E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 1,61E-04 8,814E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 1,644E-04 8,792E-03 GO:0060675|ureteric bud morphogenesis, ! intermediate filament-based process GO:0045103 24 14 2,000 1,644E-04 8,592E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,644E-04 8,401E-03 ! neural tube development GO:0021915 50 36 3,000 1,8E-04 8,998E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 2,043E-04 9,997E-03 ! regulation of catabolic process GO:0009894 106 70 4,000 2,285E-04 0,01095123 ! protein amino acid acetylation GO:0006473 28 16 2,000 2,5E-04 0,01173351 ! branched chain family amino acid metabolic process GO:0009081 24 16 2,000 2,5E-04 0,01149884 ! nerve development GO:0021675 18 16 2,000 2,5E-04 0,01127338 ! tube morphogenesis GO:0035239 118 73 4,000 2,783E-04 0,01231052 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 2,966E-04 0,01287213 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 3,018E-04 0,01285404 ! peptidyl-serine modification GO:0018209 27 17 2,000 3,018E-04 0,01262033 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 3,297E-04 0,01353986 ! heart process GO:0003015 27 18 2,000 3,601E-04 0,01452878 GO:0060047|heart contraction, ! G1/S transition of mitotic cell cycle GO:0000082 87 43 3,000 3,613E-04 0,01432611 ! positive regulation of protein catabolic process GO:0045732 23 19 2,000 4,251E-04 0,01657203 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 4,251E-04 0,01629583 ! apoptotic nuclear changes GO:0030262 24 19 2,000 4,251E-04 0,01602868 ! sex determination GO:0007530 29 19 2,000 4,251E-04 0,01577016 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 4,251E-04 0,01551984 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 2,000 4,251E-04 0,01527734 ! response to UV GO:0009411 75 46 3,000 4,69E-04 0,0165969 ! positive regulation of osteoblast differentiation GO:0045669 33 20 2,000 4,972E-04 0,01732829 ! regulation of DNA replication GO:0006275 75 48 3,000 5,525E-04 0,0189666 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 5,636E-04 0,01906256 ! anterior/posterior pattern formation GO:0009952 124 85 4,000 5,636E-04 0,01878629 ! protein amino acid acylation GO:0043543 37 21 2,000 5,768E-04 0,01895136 ! cell aging GO:0007569 32 21 2,000 5,768E-04 0,01868444 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 5,768E-04 0,01842493 ! regulation of intracellular transport GO:0032386 78 49 3,000 5,98E-04 0,01883991 ! negative regulation of bone resorption GO:0045779 10 5 1,000 6,091E-04 0,01893072 ! forebrain regionalization GO:0021871 6 5 1,000 6,091E-04 0,01867831 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 6,091E-04 0,01843254 ! neurofilament cytoskeleton organization GO:0060052 8 5 1,000 6,091E-04 0,01819316 ! positive regulation of glycolysis GO:0045821 11 5 1,000 6,091E-04 0,01795991 ! anagen GO:0042640 6 5 1,000 6,091E-04 0,01773257 ! positive regulation of viral genome replication GO:0045070 8 5 1,000 6,091E-04 0,01751091 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 1,000 6,091E-04 0,01729473 ! regulation of retroviral genome replication GO:0045091 6 5 1,000 6,091E-04 0,01708382 ! microvillus organization GO:0032528 7 5 1,000 6,091E-04 0,01687799 GO:0030033|microvillus assembly, ! response to food GO:0032094 5 5 1,000 6,091E-04 0,01667706 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 6,091E-04 0,01648086 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 1,000 6,091E-04 0,01628922 ! regulation of respiratory burst GO:0060263 8 5 1,000 6,091E-04 0,01610199 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 6,091E-04 0,01591901 GO:0007439|ectodermal gut development, ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 6,091E-04 0,01574015 ! negative regulation of smooth muscle contraction GO:0045986 9 5 1,000 6,091E-04 0,01556526 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 6,091E-04 0,01539421 GO:0022011|myelination in the peripheral nervous system, ! positive regulation of growth GO:0045927 67 50 3,000 6,46E-04 0,01615029 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 6,64E-04 0,01642167 ! viral genome replication GO:0019079 29 22 2,000 6,64E-04 0,01624697 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 2,000 6,64E-04 0,01607595 ! ureteric bud development GO:0001657 32 22 2,000 6,64E-04 0,0159085 ! leukocyte homeostasis GO:0001776 33 22 2,000 6,64E-04 0,01574449 ! neural tube closure GO:0001843 33 22 2,000 6,64E-04 0,01558383 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! protein tetramerization GO:0051262 39 22 2,000 6,64E-04 0,01542642 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 3,000 6,967E-04 0,01602491 ! positive regulation of cell migration GO:0030335 92 51 3,000 6,967E-04 0,01586625 ! regulation of protein catabolic process GO:0042176 77 51 3,000 6,967E-04 0,01571069 ! embryonic pattern specification GO:0009880 31 23 2,000 7,592E-04 0,01695332 ! myelination GO:0042552 35 23 2,000 7,592E-04 0,0167903 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 7,592E-04 0,0166304 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 7,592E-04 0,0164735 ! regulation of bone remodeling GO:0046850 90 53 3,000 8,065E-04 0,01733667 ! skeletal system morphogenesis GO:0048705 78 53 3,000 8,065E-04 0,01717614 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 8,627E-04 0,01820337 ! primary neural tube formation GO:0014020 35 24 2,000 8,627E-04 0,01803789 ! base-excision repair GO:0006284 31 24 2,000 8,627E-04 0,01787539 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 8,627E-04 0,01771578 ! regulation of oxidoreductase activity GO:0051341 39 24 2,000 8,627E-04 0,01755901 ! regulation of osteoblast differentiation GO:0045667 37 24 2,000 8,627E-04 0,01740498 ! regulation of tissue remodeling GO:0034103 91 54 3,000 8,658E-04 0,01731538 ! regulation of helicase activity GO:0051095 11 6 1,000 9,089E-04 0,01802095 ! mRNA stabilization GO:0048255 15 6 1,000 9,089E-04 0,01786692 GO:0043489|RNA stabilization, ! spinal cord dorsal/ventral patterning GO:0021513 6 6 1,000 9,089E-04 0,01771551 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 9,089E-04 0,01756664 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 9,089E-04 0,01742025 ! male sex determination GO:0030238 9 6 1,000 9,089E-04 0,01727628 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 1,000 9,089E-04 0,01713467 ! response to copper ion GO:0046688 9 6 1,000 9,089E-04 0,01699537 ! DNA topological change GO:0006265 8 6 1,000 9,089E-04 0,01685831 ! hair follicle maturation GO:0048820 7 6 1,000 9,089E-04 0,01672344 ! Schwann cell development GO:0014044 14 6 1,000 9,089E-04 0,01659072 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 9,089E-04 0,01646008 ! removal of superoxide radicals GO:0019430 10 6 1,000 9,089E-04 0,01633149 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 9,089E-04 0,01620488 ! positive regulation of cell motion GO:0051272 99 56 3,000 9,933E-04 0,01757436 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 2,000 1,095E-03 0,01923366 ! viral reproductive process GO:0022415 87 58 3,000 1,134E-03 0,0197515 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 1,000 1,266E-03 0,02189067 ! microtubule bundle formation GO:0001578 8 7 1,000 1,266E-03 0,02172731 ! T-helper 1 type immune response GO:0042088 11 7 1,000 1,266E-03 0,02156637 ! spinal cord patterning GO:0021511 7 7 1,000 1,266E-03 0,02140779 ! negative regulation of muscle contraction GO:0045932 12 7 1,000 1,266E-03 0,02125153 ! protein heterooligomerization GO:0051291 10 7 1,000 1,266E-03 0,02109753 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,266E-03 0,02094575 ! B cell lineage commitment GO:0002326 17 7 1,000 1,266E-03 0,02079614 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 1,266E-03 0,02064865 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 1,266E-03 0,02050323 ! T cell lineage commitment GO:0002360 12 7 1,000 1,266E-03 0,02035986 ! response to tumor cell GO:0002347 12 7 1,000 1,266E-03 0,02021847 ! retina homeostasis GO:0001895 9 7 1,000 1,266E-03 0,02007903 ! ensheathment of neurons GO:0007272 43 28 2,000 1,364E-03 0,02149544 GO:0008366|axon ensheathment, ! BMP signaling pathway GO:0030509 40 28 2,000 1,364E-03 0,02134921 ! neural tube formation GO:0001841 41 28 2,000 1,364E-03 0,02120496 ! placenta development GO:0001890 37 28 2,000 1,364E-03 0,02106264 ! urogenital system development GO:0001655 101 61 3,000 1,369E-03 0,02099288 ! homeostasis of number of cells GO:0048872 84 61 3,000 1,369E-03 0,02085386 ! tissue homeostasis GO:0001894 42 29 2,000 1,513E-03 0,02289704 GO:0048871|multicellular organismal homeostasis, ! viral reproduction GO:0016032 92 63 3,000 1,544E-03 0,02320857 ! embryonic skeletal system morphogenesis GO:0048704 42 30 2,000 1,672E-03 0,02496661 ! embryonic epithelial tube formation GO:0001838 44 30 2,000 1,672E-03 0,02480554 ! regulation of microtubule-based process GO:0032886 58 30 2,000 1,672E-03 0,02464653 ! response to heat GO:0009408 41 30 2,000 1,672E-03 0,02448954 ! induction of positive chemotaxis GO:0050930 14 8 1,000 1,679E-03 0,02444223 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,679E-03 0,0242885 ! smoothened signaling pathway GO:0007224 8 8 1,000 1,679E-03 0,0241367 ! keratinocyte proliferation GO:0043616 12 8 1,000 1,679E-03 0,02398678 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,679E-03 0,02383872 ! regulation of vascular permeability GO:0043114 12 8 1,000 1,679E-03 0,02369247 ! Schwann cell differentiation GO:0014037 17 8 1,000 1,679E-03 0,023548 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,679E-03 0,02340528 GO:0045685|regulation of glial cell differentiation, ! segment specification GO:0007379 10 8 1,000 1,679E-03 0,02326429 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,679E-03 0,02312498 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 1,000 1,679E-03 0,02298733 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,679E-03 0,02285131 ! induction of an organ GO:0001759 11 8 1,000 1,679E-03 0,02271689 ! myeloid cell homeostasis GO:0002262 8 8 1,000 1,679E-03 0,02258405 ! regulation of embryonic development GO:0045995 16 8 1,000 1,679E-03 0,02245274 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 1,679E-03 0,02232296 ! mammary gland development GO:0030879 57 31 2,000 1,84E-03 0,02432404 ! odontogenesis GO:0042476 50 31 2,000 1,84E-03 0,02418504 ! segmentation GO:0035282 41 31 2,000 1,84E-03 0,02404763 ! metanephros development GO:0001656 58 31 2,000 1,84E-03 0,02391177 ! cell fate specification GO:0001708 37 31 2,000 1,84E-03 0,02377743 ! peripheral nervous system development GO:0007422 53 32 2,000 2,019E-03 0,02594094 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 2,000 2,019E-03 0,02579682 ! regulation of developmental growth GO:0048638 13 9 1,000 2,148E-03 0,02729063 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 2,148E-03 0,02714068 ! positive regulation of GTPase activity GO:0043547 21 9 1,000 2,148E-03 0,02699237 ! regulation of glycolysis GO:0006110 15 9 1,000 2,148E-03 0,02684567 ! lung alveolus development GO:0048286 17 9 1,000 2,148E-03 0,02670056 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 2,148E-03 0,02655701 ! ventral spinal cord development GO:0021517 11 9 1,000 2,148E-03 0,026415 ! motor axon guidance GO:0008045 14 9 1,000 2,148E-03 0,02627449 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 1,000 2,148E-03 0,02613547 ! DNA ligation GO:0006266 14 9 1,000 2,148E-03 0,02599792 ! thymus development GO:0048538 15 9 1,000 2,148E-03 0,0258618 ! localization within membrane GO:0051668 15 9 1,000 2,148E-03 0,02572711 ! nucleus organization GO:0006997 49 33 2,000 2,208E-03 0,02631339 ! regulation of proteolysis GO:0030162 50 33 2,000 2,208E-03 0,02617775 ! negative regulation of hydrolase activity GO:0051346 50 33 2,000 2,208E-03 0,02604351 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 2,278E-03 0,02672736 ! phosphoinositide-mediated signaling GO:0048015 109 71 3,000 2,399E-03 0,02800896 ! dorsal/ventral pattern formation GO:0009953 44 34 2,000 2,408E-03 0,02796983 ! regulation of action potential in neuron GO:0019228 54 35 2,000 2,618E-03 0,03026387 ! glycogen metabolic process GO:0005977 48 35 2,000 2,618E-03 0,03011255 ! mitochondrion organization GO:0007005 104 73 3,000 2,655E-03 0,03038095 ! negative regulation of muscle development GO:0048635 12 10 1,000 2,671E-03 0,03040899 ! neuron fate specification GO:0048665 11 10 1,000 2,671E-03 0,03025919 ! blood vessel remodeling GO:0001974 21 10 1,000 2,671E-03 0,03011086 ! negative regulation of lipid metabolic process GO:0045833 14 10 1,000 2,671E-03 0,02996398 ! pathogenesis GO:0009405 13 10 1,000 2,671E-03 0,02981852 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,671E-03 0,02967447 ! glucan biosynthetic process GO:0009250 13 10 1,000 2,671E-03 0,02953181 GO:0005978|glycogen biosynthetic process, ! response to X-ray GO:0010165 16 10 1,000 2,671E-03 0,02939051 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 2,671E-03 0,02925055 ! regulation of bone resorption GO:0045124 24 10 1,000 2,671E-03 0,02911192 ! regulation of organ growth GO:0046620 11 10 1,000 2,671E-03 0,0289746 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 2,671E-03 0,02883857 ! positive regulation of viral reproduction GO:0048524 15 10 1,000 2,671E-03 0,02870381 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,671E-03 0,02857031 GO:0043470|regulation of carbohydrate catabolic process, ! embryonic gut development GO:0048566 11 10 1,000 2,671E-03 0,02843804 ! cardiac cell differentiation GO:0035051 16 10 1,000 2,671E-03 0,02830699 ! developmental induction GO:0031128 13 10 1,000 2,671E-03 0,02817714 GO:0045168|cell-cell signaling involved in cell fate specification, ! glucan metabolic process GO:0044042 49 36 2,000 2,84E-03 0,02982823 GO:0006073|cellular glucan metabolic process, ! regulation of protein transport GO:0051223 114 76 3,000 3,073E-03 0,03212939 GO:0070201|regulation of establishment of protein localization, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 1,000 3,247E-03 0,03379589 ! virus-host interaction GO:0019048 17 11 1,000 3,247E-03 0,03364365 ! regulation of positive chemotaxis GO:0050926 17 11 1,000 3,247E-03 0,03349278 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 1,000 3,247E-03 0,03334326 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 3,247E-03 0,03319507 ! negative regulation of proteolysis GO:0045861 16 11 1,000 3,247E-03 0,03304819 ! regulation of mRNA processing GO:0050684 18 11 1,000 3,247E-03 0,0329026 ! plasma membrane organization GO:0007009 18 11 1,000 3,247E-03 0,03275829 ! regulation of intracellular pH GO:0051453 17 11 1,000 3,247E-03 0,03261524 ! T cell homeostasis GO:0043029 20 11 1,000 3,247E-03 0,03247344 ! regulation of leukocyte migration GO:0002685 24 11 1,000 3,247E-03 0,03233286 ! regulation of osteoclast differentiation GO:0045670 15 11 1,000 3,247E-03 0,0321935 ! digestive tract morphogenesis GO:0048546 15 11 1,000 3,247E-03 0,03205533 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 3,247E-03 0,03191834 GO:0042130|negative regulation of T cell proliferation, ! regulation of steroid biosynthetic process GO:0050810 11 11 1,000 3,247E-03 0,03178251 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 2,000 3,317E-03 0,03233044 ! morphogenesis of embryonic epithelium GO:0016331 60 39 2,000 3,573E-03 0,03467732 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 3,573E-03 0,03453162 ! developmental growth GO:0048589 62 39 2,000 3,573E-03 0,03438714 ! synapse organization GO:0050808 55 39 2,000 3,573E-03 0,03424386 ! induction of apoptosis by intracellular signals GO:0008629 67 40 2,000 3,841E-03 0,03665593 ! double-strand break repair GO:0006302 67 40 2,000 3,841E-03 0,03650446 ! positive regulation of protein transport GO:0051222 55 40 2,000 3,841E-03 0,03635424 ! cartilage condensation GO:0001502 18 12 1,000 3,877E-03 0,03654277 ! auditory receptor cell differentiation GO:0042491 25 12 1,000 3,877E-03 0,03639362 ! positive regulation of cell growth GO:0030307 16 12 1,000 3,877E-03 0,03624568 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 3,877E-03 0,03609894 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! autonomic nervous system development GO:0048483 23 12 1,000 3,877E-03 0,03595338 ! response to gamma radiation GO:0010332 20 12 1,000 3,877E-03 0,03580898 ! regulation of mRNA stability GO:0043488 27 12 1,000 3,877E-03 0,03566575 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 3,877E-03 0,03552365 ! ossification GO:0001503 134 82 3,000 4,04E-03 0,03687641 GO:0060348|bone development, ! energy reserve metabolic process GO:0006112 59 41 2,000 4,12E-03 0,03745856 ! regulation of T cell differentiation GO:0045580 59 41 2,000 4,12E-03 0,03731109 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 4,412E-03 0,03979487 ! embryonic skeletal system development GO:0048706 56 42 2,000 4,412E-03 0,03963942 ! copper ion transport GO:0006825 15 13 1,000 4,558E-03 0,04079099 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 4,558E-03 0,04063289 ! bone mineralization GO:0030282 15 13 1,000 4,558E-03 0,040476 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,558E-03 0,04032033 ! regulation of cellular pH GO:0030641 20 13 1,000 4,558E-03 0,04016584 ! positive regulation of bone mineralization GO:0030501 19 13 1,000 4,558E-03 0,04001254 ! regulation of RNA stability GO:0043487 28 13 1,000 4,558E-03 0,0398604 ! lymphocyte homeostasis GO:0002260 24 13 1,000 4,558E-03 0,03970941 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 4,593E-03 0,03986621 ! regulation of protein localization GO:0032880 132 85 3,000 4,593E-03 0,03971634 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 4,788E-03 0,04124785 ! regulation of action potential GO:0001508 71 44 2,000 5,032E-03 0,04318515 ! cellular amino acid biosynthetic process GO:0008652 51 44 2,000 5,032E-03 0,04302461 ! interphase GO:0051325 159 88 3,000 5,195E-03 0,04425369 ! superoxide anion generation GO:0042554 18 14 1,000 5,29E-03 0,04489848 ! regulation of lipid biosynthetic process GO:0046890 16 14 1,000 5,29E-03 0,04473341 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,29E-03 0,04456956 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 5,29E-03 0,04440689 ! heterophilic cell adhesion GO:0007157 29 14 1,000 5,29E-03 0,04424541 ! cardiac muscle contraction GO:0060048 23 14 1,000 5,29E-03 0,0440851 ! cellular response to starvation GO:0009267 21 14 1,000 5,29E-03 0,04392595 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 5,29E-03 0,04376794 GO:0031114|regulation of microtubule depolymerization, ! negative regulation of caspase activity GO:0043154 20 14 1,000 5,29E-03 0,04361107 ! embryo implantation GO:0007566 27 14 1,000 5,29E-03 0,04345532 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 5,29E-03 0,04330067 ! G1/S transition checkpoint GO:0031575 33 14 1,000 5,29E-03 0,04314712 ! axon cargo transport GO:0008088 27 14 1,000 5,29E-03 0,04299466 ! positive regulation of biomineral formation GO:0070169 20 14 1,000 5,29E-03 0,04284327 ! muscle maintenance GO:0046716 19 14 1,000 5,29E-03 0,04269294 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 5,29E-03 0,04254367 ! positive regulation of cell cycle GO:0045787 77 45 2,000 5,361E-03 0,04296 ! vascular process in circulatory system GO:0003018 69 45 2,000 5,361E-03 0,04281084 ! reproductive developmental process GO:0003006 127 89 3,000 5,407E-03 0,04302943 ! regulation of ossification GO:0030278 71 46 2,000 5,702E-03 0,04522226 ! histone modification GO:0016570 68 46 2,000 5,702E-03 0,04506686 ! viral infectious cycle GO:0019058 71 47 2,000 6,056E-03 0,04770108 ! covalent chromatin modification GO:0016569 75 47 2,000 6,056E-03 0,04753827 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 6,056E-03 0,04737658 ! positive regulation of cell size GO:0045793 20 15 1,000 6,073E-03 0,04734619 ! skin development GO:0043588 25 15 1,000 6,073E-03 0,04718623 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 6,073E-03 0,04702736 ! lipid phosphorylation GO:0046834 23 15 1,000 6,073E-03 0,04686955 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 6,073E-03 0,04671279 ! positive regulation of proteolysis GO:0045862 19 15 1,000 6,073E-03 0,04655708 ! regulation of survival gene product expression GO:0045884 20 15 1,000 6,073E-03 0,04640241 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 6,073E-03 0,04624876 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 6,073E-03 0,04609612 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 6,073E-03 0,04594449 ! biomineral formation GO:0031214 18 15 1,000 6,073E-03 0,04579385 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 6,073E-03 0,0456442 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 1,000 6,073E-03 0,04549552 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 6,073E-03 0,04534781 ! response to temperature stimulus GO:0009266 62 48 2,000 6,423E-03 0,0478077 ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 6,423E-03 0,04765348 ! heart morphogenesis GO:0003007 65 48 2,000 6,423E-03 0,04750025 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 6,423E-03 0,04734801 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 6,803E-03 0,04998822 ! germ cell development GO:0007281 68 49 2,000 6,803E-03 0,04982902 ! cartilage development GO:0051216 70 49 2,000 6,803E-03 0,04967083 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 6,904E-03 0,0502541 ! glial cell development GO:0021782 24 16 1,000 6,904E-03 0,05009557 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 6,904E-03 0,04993803 ! regulation of steroid metabolic process GO:0019218 21 16 1,000 6,904E-03 0,04978149 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 6,904E-03 0,04962592 ! inner ear receptor cell differentiation GO:0060113 30 16 1,000 6,904E-03 0,04947132 ! response to light stimulus GO:0009416 153 96 3,000 7,052E-03 0,05037265 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 7,196E-03 0,05123893 ! forelimb morphogenesis GO:0035136 19 17 1,000 7,785E-03 0,05526271 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 7,785E-03 0,05509267 ! regulation of viral genome replication GO:0045069 24 17 1,000 7,785E-03 0,05492367 ! neuromuscular junction development GO:0007528 23 17 1,000 7,785E-03 0,05475571 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 7,785E-03 0,05458877 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 7,785E-03 0,05442285 ! synaptogenesis GO:0007416 24 17 1,000 7,785E-03 0,05425793 ! proximal/distal pattern formation GO:0009954 25 17 1,000 7,785E-03 0,05409401 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 7,785E-03 0,05393108 ! aging GO:0007568 79 52 2,000 8,021E-03 0,05540311 ! nucleotide-excision repair GO:0006289 64 52 2,000 8,021E-03 0,05523723 ! homophilic cell adhesion GO:0007156 149 100 3,000 8,126E-03 0,05579234 ! kidney development GO:0001822 90 53 2,000 8,454E-03 0,05787169 ! positive regulation of DNA replication GO:0045740 29 18 1,000 8,713E-03 0,0594651 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 8,713E-03 0,05928917 ! protein amino acid ADP-ribosylation GO:0006471 27 18 1,000 8,713E-03 0,05911428 ! mechanoreceptor differentiation GO:0042490 32 18 1,000 8,713E-03 0,05894041 ! somitogenesis GO:0001756 24 18 1,000 8,713E-03 0,05876757 ! cellular response to nutrient levels GO:0031669 27 18 1,000 8,713E-03 0,05859573 ! gut development GO:0048565 26 18 1,000 8,713E-03 0,0584249 ! negative regulation of T cell activation GO:0050868 25 18 1,000 8,713E-03 0,05825506 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 8,713E-03 0,0580862 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 9,688E-03 0,06439979 ! positive regulation of ossification GO:0045778 30 19 1,000 9,688E-03 0,0642142 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 9,688E-03 0,06402967 GO:0010675|regulation of cellular carbohydrate metabolic process, ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 9,688E-03 0,06384621 ! response to starvation GO:0042594 30 19 1,000 9,688E-03 0,06366379 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 9,688E-03 0,06348241 ! vasodilation GO:0042311 33 19 1,000 9,688E-03 0,06330206 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 9,688E-03 0,06312274 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 9,688E-03 0,06294443 ! embryonic organ morphogenesis GO:0048562 23 19 1,000 9,688E-03 0,06276712 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 9,834E-03 0,06353599 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 0,01032162 0,06649786 ! gonad development GO:0008406 79 57 2,000 0,01032162 0,06631211 ! microtubule-based transport GO:0010970 37 20 1,000 0,01070916 0,06861021 ! hindlimb morphogenesis GO:0035137 32 20 1,000 0,01070916 0,06841963 ! spinal cord development GO:0021510 31 20 1,000 0,01070916 0,0682301 ! response to ethanol GO:0045471 37 20 1,000 0,01070916 0,06804162 ! chromosome condensation GO:0030261 31 20 1,000 0,01070916 0,06785418 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 0,01070916 0,06766777 ! positive regulation of locomotion GO:0040017 35 20 1,000 0,01070916 0,06748237 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! camera-type eye morphogenesis GO:0048593 34 20 1,000 0,01070916 0,067298 ! negative regulation of kinase activity GO:0033673 100 58 2,000 0,01082279 0,06782676 ! activation of MAPK activity GO:0000187 84 59 2,000 0,01133784 0,07086147 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 0,01177573 0,07339883 ! positive regulation of bone remodeling GO:0046852 33 21 1,000 0,01177573 0,07320046 GO:0034105|positive regulation of tissue remodeling, ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 0,01177573 0,07300315 ! regulation of chemotaxis GO:0050920 36 21 1,000 0,01177573 0,07280691 ! dendrite development GO:0016358 35 21 1,000 0,01177573 0,07261171 ! ovarian follicle development GO:0001541 30 21 1,000 0,01177573 0,07241756 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 0,01177573 0,07222445 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01177573 0,07203236 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01177573 0,0718413 ! regulation of bone mineralization GO:0030500 29 21 1,000 0,01177573 0,07165124 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 0,01186682 0,072015 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of transferase activity GO:0051348 105 61 2,000 0,01240981 0,07511198 ! molting cycle process GO:0022404 40 22 1,000 0,0128869 0,07779492 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! vasculogenesis GO:0001570 33 22 1,000 0,0128869 0,07759127 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,0128869 0,07738868 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 0,0128869 0,07718715 ! regulation of behavior GO:0050795 38 22 1,000 0,0128869 0,07698666 ! neuron fate commitment GO:0048663 32 23 1,000 0,01404192 0,08366944 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01404192 0,08345324 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01404192 0,08323816 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01404192 0,08302418 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01404192 0,08281129 ! osteoblast differentiation GO:0001649 40 23 1,000 0,01404192 0,0825995 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01404192 0,08238879 ! hydrogen peroxide metabolic process GO:0042743 30 23 1,000 0,01404192 0,08217915 ! interaction with host GO:0051701 37 23 1,000 0,01404192 0,08197057 ! regulation of biomineral formation GO:0070167 31 23 1,000 0,01404192 0,08176305 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01404192 0,08155658 ! negative regulation of cell size GO:0045792 108 64 2,000 0,0141233 0,08182264 ! appendage morphogenesis GO:0035107 93 64 2,000 0,0141233 0,08161705 GO:0035108|limb morphogenesis, ! reproductive structure development GO:0048608 90 65 2,000 0,0147228 0,08486827 ! regulation of caspase activity GO:0043281 97 65 2,000 0,0147228 0,0846561 ! appendage development GO:0048736 94 65 2,000 0,0147228 0,08444499 GO:0060173|limb development, ! protein oligomerization GO:0051259 100 65 2,000 0,0147228 0,08423492 ! superoxide metabolic process GO:0006801 32 24 1,000 0,01524003 0,08697782 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,01524003 0,08676253 ! mitochondrial membrane organization GO:0007006 39 24 1,000 0,01524003 0,0865483 ! negative regulation of cell development GO:0010721 56 24 1,000 0,01524003 0,08633513 GO:0050768|negative regulation of neurogenesis, ! glutathione metabolic process GO:0006749 29 24 1,000 0,01524003 0,086123 ! axon guidance GO:0007411 99 66 2,000 0,01533654 0,08645598 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,01596455 0,0897762 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 0,01648049 0,09245154 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 0,01648049 0,0922266 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01648049 0,09200275 ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01648049 0,09177998 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01648049 0,09155829 ! development of primary sexual characteristics GO:0045137 92 68 2,000 0,01660687 0,09203806 ! response to drug GO:0042493 108 69 2,000 0,01726352 0,09544734 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,01776258 0,09797104 ! regulation of pH GO:0006885 36 26 1,000 0,01776258 0,09773666 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01776258 0,0975034 ! negative regulation of protein kinase cascade GO:0010741 51 26 1,000 0,01776258 0,09727125 ! inner ear morphogenesis GO:0042472 35 27 1,000 0,01908556 0,10426788 ! response to ionizing radiation GO:0010212 47 27 1,000 0,01908556 0,1040208 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01908556 0,10377489 ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01908556 0,10353013 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01908556 0,10328653 ! regulation of peptidase activity GO:0052547 106 72 2,000 0,01931971 0,10430827 ! response to hypoxia GO:0001666 132 72 2,000 0,01931971 0,10406399 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,02044871 0,10988795 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,02044871 0,1096318 ! response to oxygen levels GO:0070482 137 74 2,000 0,02076253 0,1110554 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,02185134 0,11660811 ! ovulation cycle process GO:0022602 41 29 1,000 0,02185134 0,11633818 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,02185134 0,1160695 ! telencephalon development GO:0021537 52 29 1,000 0,02185134 0,11580206 ! eye morphogenesis GO:0048592 51 29 1,000 0,02185134 0,11553585 ! amine biosynthetic process GO:0009309 97 76 2,000 0,02226308 0,11744285 ! gland development GO:0048732 148 77 2,000 0,02303501 0,12123691 ! sex differentiation GO:0007548 105 77 2,000 0,02303501 0,12096011 ! protein ubiquitination GO:0016567 125 77 2,000 0,02303501 0,12068458 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,02329275 0,12175756 ! ovulation cycle GO:0042698 43 30 1,000 0,02329275 0,12148146 ! hindbrain development GO:0030902 45 30 1,000 0,02329275 0,12120662 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,02329275 0,12093301 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02477224 0,12832466 ! glial cell differentiation GO:0010001 55 31 1,000 0,02477224 0,12803629 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,02477224 0,12774921 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02477224 0,12746342 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02477224 0,1271789 ! regulation of muscle development GO:0048634 48 32 1,000 0,02628913 0,13466592 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,02628913 0,13436666 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,02628913 0,13406873 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02628913 0,13377212 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,02784275 0,14136494 ! ear morphogenesis GO:0042471 42 33 1,000 0,02784275 0,14105357 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,02784275 0,14074356 GO:0042593|glucose homeostasis, ! female gonad development GO:0008585 49 33 1,000 0,02784275 0,14043491 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02784275 0,14012761 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,02784275 0,13982166 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,02884237 0,14452603 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02943243 0,14716215 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02943243 0,14684292 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02943243 0,14652508 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,02943243 0,14620861 ! neuron migration GO:0001764 46 34 1,000 0,02943243 0,14589351 ! embryonic organ development GO:0048568 45 34 1,000 0,02943243 0,14557976 ! regulation of membrane potential GO:0042391 128 85 2,000 0,02972953 0,14673373 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,02972953 0,14641953 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,03105752 0,1526331 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,03105752 0,15230765 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,03154681 0,154378 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 0,03154681 0,15405024 ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,03247687 0,15825595 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,03271736 0,15909076 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,03271736 0,15875513 ! tissue remodeling GO:0048771 62 36 1,000 0,03271736 0,15842091 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,03271736 0,15808809 GO:0046660|female sex differentiation, ! regulation of neurogenesis GO:0050767 153 89 2,000 0,03342118 0,16115035 ! regulation of T cell activation GO:0050863 128 89 2,000 0,03342118 0,16081321 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 0,0343797 0,16507997 ! amino acid activation GO:0043038 52 37 1,000 0,03441132 0,16488758 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! gliogenesis GO:0042063 71 38 1,000 0,03613876 0,17280489 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,03613876 0,17244637 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03613876 0,17208934 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,03734015 0,17744286 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,03734015 0,17707699 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,03789906 0,17935768 ! male sex differentiation GO:0046661 53 39 1,000 0,03789906 0,17898939 ! chromatin remodeling GO:0006338 68 39 1,000 0,03789906 0,17862261 ! cell growth GO:0016049 61 39 1,000 0,03789906 0,17825733 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03885532 0,1823821 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03885532 0,18201065 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03885532 0,18164071 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03885532 0,18127227 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03885532 0,18090532 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03885532 0,18053986 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03885532 0,18017586 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03885532 0,17981334 ! sleep GO:0030431 11 5 0,000 0,03885532 0,17945227 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03885532 0,17909264 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03885532 0,17873446 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03885532 0,1783777 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03885532 0,17802237 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 6 5 0,000 0,03885532 0,17766845 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03885532 0,17731593 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03885532 0,17696481 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03885532 0,17661508 ! cobalt ion transport GO:0006824 9 5 0,000 0,03885532 0,17626672 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03885532 0,17591974 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03885532 0,17557412 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03885532 0,17522986 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03885532 0,17488695 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03885532 0,17454537 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03885532 0,17420512 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03885532 0,1738662 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03885532 0,1735286 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03885532 0,1731923 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03885532 0,17285731 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03885532 0,17252361 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03885532 0,17219119 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03885532 0,17186006 ! malate metabolic process GO:0006108 7 5 0,000 0,03885532 0,17153019 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03885532 0,17120159 ! behavioral response to pain GO:0048266 7 5 0,000 0,03885532 0,17087424 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03885532 0,17054815 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03885532 0,17022329 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03885532 0,16989967 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03885532 0,16957728 ! mating behavior GO:0007617 6 5 0,000 0,03885532 0,16925612 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03885532 0,16893616 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03885532 0,16861741 ! rhythmic behavior GO:0007622 12 5 0,000 0,03885532 0,16829987 ! copulation GO:0007620 7 5 0,000 0,03885532 0,16798351 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03885532 0,16766835 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03885532 0,16735436 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03885532 0,16704155 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03885532 0,1667299 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03885532 0,16641942 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03885532 0,16611009 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03885532 0,16580191 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03885532 0,16549487 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03885532 0,16518896 ! response to protozoan GO:0001562 9 5 0,000 0,03885532 0,16488419 ! lymph vessel development GO:0001945 7 5 0,000 0,03885532 0,16458053 ! endochondral ossification GO:0001958 12 5 0,000 0,03885532 0,16427799 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03885532 0,16397657 ! parathyroid gland development GO:0060017 8 5 0,000 0,03885532 0,16367624 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03885532 0,16337702 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03885532 0,16307888 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03885532 0,16278184 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03885532 0,16248587 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03885532 0,16219098 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03885532 0,16189715 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03885532 0,16160439 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03885532 0,16131269 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03885532 0,16102203 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03885532 0,16073243 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,03885532 0,16044386 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03885532 0,16015632 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03885532 0,15986982 ! ovulation GO:0030728 6 5 0,000 0,03885532 0,15958434 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03885532 0,15929987 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,03885532 0,15901642 ! response to pH GO:0009268 9 5 0,000 0,03885532 0,15873398 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03885532 0,15845253 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03885532 0,15817209 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03885532 0,15789263 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03885532 0,15761416 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03885532 0,15733667 ! polyol catabolic process GO:0046174 7 5 0,000 0,03885532 0,15706016 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03885532 0,15678461 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03885532 0,15651003 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03885532 0,15623641 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03885532 0,15596375 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03885532 0,15569204 ! urea metabolic process GO:0019627 6 5 0,000 0,03885532 0,15542127 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03885532 0,15515144 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03885532 0,15488255 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03885532 0,15461458 ! neutrophil activation GO:0042119 5 5 0,000 0,03885532 0,15434755 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03885532 0,15408143 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03885532 0,15381623 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03885532 0,15355194 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03885532 0,15328856 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03885532 0,15302608 ! forebrain neuron development GO:0021884 7 5 0,000 0,03885532 0,15276449 ! melanosome organization GO:0032438 7 5 0,000 0,03885532 0,1525038 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03885532 0,152244 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03885532 0,15198508 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03885532 0,15172704 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03885532 0,15146988 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03885532 0,15121359 ! nucleoside transport GO:0015858 6 5 0,000 0,03885532 0,15095816 ! nucleoside salvage GO:0043174 7 5 0,000 0,03885532 0,15070359 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03885532 0,15044988 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03885532 0,15019702 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03885532 0,14994501 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03885532 0,14969385 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03885532 0,14944353 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03885532 0,14919404 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03885532 0,14894538 ! depyrimidination GO:0045008 8 5 0,000 0,03885532 0,14869755 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03885532 0,14845055 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03885532 0,14820436 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03885532 0,14795899 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03885532 0,14771443 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03885532 0,14747067 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03885532 0,14722772 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03885532 0,14698557 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03885532 0,14674422 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03885532 0,14650365 ! monocyte differentiation GO:0030224 8 5 0,000 0,03885532 0,14626388 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03885532 0,14602488 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03885532 0,14578667 ! centrosome duplication GO:0051298 5 5 0,000 0,03885532 0,14554923 ! response to UV-C GO:0010225 6 5 0,000 0,03885532 0,14531257 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03885532 0,14507667 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03885532 0,14484154 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03885532 0,14460717 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03885532 0,14437355 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03885532 0,14414069 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03885532 0,14390858 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03885532 0,14367722 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03885532 0,1434466 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03885532 0,14321671 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03885532 0,14298757 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03885532 0,14275915 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03885532 0,14253147 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03885532 0,1423045 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03885532 0,14207827 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03885532 0,14185274 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03885532 0,14162794 ! neural tube patterning GO:0021532 6 5 0,000 0,03885532 0,14140384 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03885532 0,14118046 ! histone demethylation GO:0016577 9 5 0,000 0,03885532 0,14095777 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03885532 0,14073579 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03885532 0,14051451 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03885532 0,14029392 ! enteric nervous system development GO:0048484 8 5 0,000 0,03885532 0,14007403 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03885532 0,13985482 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03885532 0,1396363 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03885532 0,13941845 ! transcription termination GO:0006353 8 5 0,000 0,03885532 0,13920129 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03885532 0,1389848 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03885532 0,13876899 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03885532 0,13855384 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03885532 0,13833936 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03885532 0,13812555 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03885532 0,13791239 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03885532 0,13769989 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03885532 0,13748804 ! apical protein localization GO:0045176 6 5 0,000 0,03885532 0,13727685 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03885532 0,1370663 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03885532 0,1368564 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03885532 0,13664714 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03885532 0,13643852 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03885532 0,13623053 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03885532 0,13602318 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03885532 0,13581646 ! glial cell migration GO:0008347 10 5 0,000 0,03885532 0,13561036 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03885532 0,13540489 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03885532 0,13520004 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03885532 0,13499581 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03885532 0,1347922 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03885532 0,1345892 ! neural plate development GO:0001840 6 5 0,000 0,03885532 0,13438681 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03885532 0,13418503 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03885532 0,13398385 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03885532 0,13378328 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03885532 0,1335833 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03885532 0,13338392 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03885532 0,13318514 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03885532 0,13298695 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03885532 0,13278934 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! spindle assembly GO:0051225 5 5 0,000 0,03885532 0,13259233 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03885532 0,13239589 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03885532 0,13220004 ! organ regeneration GO:0031100 7 5 0,000 0,03885532 0,13200477 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03885532 0,13181007 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03885532 0,13161595 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03885532 0,1314224 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03885532 0,13122941 GO:0055081|anion homeostasis, ! angiogenesis GO:0001525 149 95 2,000 0,03938413 0,13282039 ! regulation of tube size GO:0035150 60 40 1,000 0,03969159 0,13366129 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,03969159 0,13346588 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 1,000 0,03969159 0,13327104 ! peptide metabolic process GO:0006518 56 40 1,000 0,03969159 0,13307677 ! inner ear development GO:0048839 57 40 1,000 0,03969159 0,13288306 ! T cell differentiation GO:0030217 65 40 1,000 0,03969159 0,13268992 ! B cell differentiation GO:0030183 62 40 1,000 0,03969159 0,13249733 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,03969159 0,13230531 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,03969159 0,13211384 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,03969159 0,13192292 ! in utero embryonic development GO:0001701 147 96 2,000 0,0404271 0,13417364 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,0404271 0,1339803 ! glucose transport GO:0015758 52 41 1,000 0,04151575 0,13739027 ! striated muscle contraction GO:0006941 62 41 1,000 0,04151575 0,13719287 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,04151575 0,13699603 ! mitochondrial transport GO:0006839 60 42 1,000 0,04337094 0,14291284 ! cellular component disassembly GO:0022411 64 42 1,000 0,04337094 0,14270839 ! hexose transport GO:0008645 54 42 1,000 0,04337094 0,14250452 GO:0015749|monosaccharide transport, ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,04337094 0,14230123 ! regulation of cell shape GO:0008360 78 42 1,000 0,04337094 0,14209852 ! extracellular structure organization GO:0043062 156 99 2,000 0,04363932 0,14277444 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,04363932 0,14257164 ! positive regulation of binding GO:0051099 59 43 1,000 0,04525655 0,1476455 ! activation of caspase activity GO:0006919 65 43 1,000 0,04525655 0,14743637 ! tRNA transcription GO:0009304 11 6 0,000 0,0464446 0,15109277 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,0464446 0,15087936 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,0464446 0,15066656 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,0464446 0,15045435 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,0464446 0,15024274 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,0464446 0,15003173 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,0464446 0,1498213 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,0464446 0,14961147 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,0464446 0,14940222 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,0464446 0,14919356 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,0464446 0,14898548 ! prostate gland development GO:0030850 9 6 0,000 0,0464446 0,14877798 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,0464446 0,14857106 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,0464446 0,14836471 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,0464446 0,14815893 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,0464446 0,14795372 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,0464446 0,14774909 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,0464446 0,14754501 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,0464446 0,1473415 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,0464446 0,14713855 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,0464446 0,14693616 ! neuron adhesion GO:0007158 9 6 0,000 0,0464446 0,14673433 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,0464446 0,14653304 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,0464446 0,14633231 ! signal peptide processing GO:0006465 8 6 0,000 0,0464446 0,14613213 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,0464446 0,1459325 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,0464446 0,14573341 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,0464446 0,14553486 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,0464446 0,14533686 ! opsonization GO:0008228 8 6 0,000 0,0464446 0,14513939 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,0464446 0,14494245 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,0464446 0,14474606 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,0464446 0,14455019 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,0464446 0,14435485 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,0464446 0,14416004 ! photoreceptor cell development GO:0042461 10 6 0,000 0,0464446 0,14396575 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,0464446 0,14377199 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,0464446 0,14357875 ! mechanosensory behavior GO:0007638 8 6 0,000 0,0464446 0,14338603 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,0464446 0,14319382 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,0464446 0,14300213 ! response to interferon-gamma GO:0034341 12 6 0,000 0,0464446 0,14281095 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,0464446 0,14262028 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,0464446 0,14243012 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,0464446 0,14224046 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,0464446 0,14205131 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,0464446 0,14186267 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,0464446 0,14167452 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,0464446 0,14148687 ! thymic T cell selection GO:0045061 12 6 0,000 0,0464446 0,14129972 ! protein lipoylation GO:0009249 10 6 0,000 0,0464446 0,14111306 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,0464446 0,1409269 ! pigment granule organization GO:0048753 11 6 0,000 0,0464446 0,14074122 ! drug transport GO:0015893 6 6 0,000 0,0464446 0,14055604 ! cysteine metabolic process GO:0006534 7 6 0,000 0,0464446 0,14037134 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,0464446 0,14018712 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,0464446 0,14000339 ! histidine metabolic process GO:0006547 6 6 0,000 0,0464446 0,13982014 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,0464446 0,13963737 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,0464446 0,13945508 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,0464446 0,13927326 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,0464446 0,13909191 ! adenohypophysis development GO:0021984 10 6 0,000 0,0464446 0,13891104 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,0464446 0,13873063 ! hyperosmotic response GO:0006972 8 6 0,000 0,0464446 0,1385507 ! microtubule nucleation GO:0007020 10 6 0,000 0,0464446 0,13837123 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,0464446 0,13819222 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,0464446 0,13801368 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,0464446 0,1378356 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,0464446 0,13765798 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,0464446 0,13748081 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,0464446 0,1373041 ! response to dietary excess GO:0002021 7 6 0,000 0,0464446 0,13712784 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,0464446 0,13695204 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,0464446 0,13677668 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,0464446 0,13660178 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,0464446 0,13642732 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,0464446 0,1362533 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,0464446 0,13607973 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,0464446 0,1359066 ! neuron apoptosis GO:0051402 8 6 0,000 0,0464446 0,13573391 ! organic alcohol transport GO:0015850 9 6 0,000 0,0464446 0,13556166 ! T cell mediated immunity GO:0002456 12 6 0,000 0,0464446 0,13538985 ! carnitine transport GO:0015879 8 6 0,000 0,0464446 0,13521847 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,0464446 0,13504752 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,0464446 0,13487701 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,0464446 0,13470692 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,0464446 0,13453727 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,0464446 0,13436804 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,0464446 0,13419923 ! parturition GO:0007567 12 6 0,000 0,0464446 0,13403085 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,0464446 0,13386289 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,0464446 0,13369536 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,0464446 0,13352824 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,0464446 0,13336153 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,0464446 0,13319525 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,0464446 0,13302938 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,0464446 0,13286392 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,0464446 0,13269887 ! macrophage differentiation GO:0030225 10 6 0,000 0,0464446 0,13253423 ! astrocyte development GO:0014002 14 6 0,000 0,0464446 0,13237 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,0464446 0,13220617 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,0464446 0,13204275 ! interaction with symbiont GO:0051702 8 6 0,000 0,0464446 0,13187974 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,0464446 0,13171713 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,0464446 0,13155491 ! eating behavior GO:0042755 6 6 0,000 0,0464446 0,1313931 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,0464446 0,13123168 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,0464446 0,13107066 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,0464446 0,13091004 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,0464446 0,1307498 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,0464446 0,13058996 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,0464446 0,13043051 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,0464446 0,13027145 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,0464446 0,13011278 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,0464446 0,12995449 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,0464446 0,12979658 ! gas homeostasis GO:0033483 11 6 0,000 0,0464446 0,12963906 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,0464446 0,12948193 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,0464446 0,12932517 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,0464446 0,12916879 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,0464446 0,12901279 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,0464446 0,12885716 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,0464446 0,12870191 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,0464446 0,12854704 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,0464446 0,12839253 ! histone ubiquitination GO:0016574 7 6 0,000 0,0464446 0,1282384 ! regulation of meiosis GO:0040020 10 6 0,000 0,0464446 0,12808464 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,0464446 0,12793124 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,0464446 0,12777822 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,0464446 0,12762555 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,0464446 0,12747326 ! membrane to membrane docking GO:0022614 12 6 0,000 0,0464446 0,12732132 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,0464446 0,12716975 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,0464446 0,12701854 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,0464446 0,12686768 ! receptor internalization GO:0031623 9 6 0,000 0,0464446 0,12671719 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,0464446 0,12656705 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,0464446 0,12641726 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,0464446 0,12626784 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,0464446 0,12611876 ! protein deubiquitination GO:0016579 8 6 0,000 0,0464446 0,12597003 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,0464446 0,12582166 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,0464446 0,12567363 ! axonal fasciculation GO:0007413 9 6 0,000 0,0464446 0,12552596 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,0464446 0,12537863 ! thiamin metabolic process GO:0006772 6 6 0,000 0,0464446 0,12523164 ! midbrain development GO:0030901 6 6 0,000 0,0464446 0,125085 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,0464446 0,1249387 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,0464446 0,12479274 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,0464446 0,12464713 ! progesterone metabolic process GO:0042448 8 6 0,000 0,0464446 0,12450185 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,0464446 0,12435691 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,0464446 0,12421231 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,0464446 0,12406805 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,0464446 0,12392412 GO:0010828|positive regulation of glucose transport, ! adult feeding behavior GO:0008343 6 6 0,000 0,0464446 0,12378052 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,0464446 0,12363726 ! blastocyst growth GO:0001832 15 6 0,000 0,0464446 0,12349432 ! pigment granule transport GO:0051904 12 6 0,000 0,0464446 0,12335172 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,0464446 0,12320944 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,0464446 0,1230675 ! catecholamine transport GO:0051937 7 6 0,000 0,0464446 0,12292588 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,0464446 0,12278458 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,0464446 0,12264361 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,0464446 0,12250297 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,0464446 0,12236264 ! protein prenylation GO:0018342 10 6 0,000 0,0464446 0,12222264 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,0464446 0,12208296 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,0464446 0,12194359 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,0464446 0,12180455 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,0464446 0,12166582 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,04717201 0,12343074 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,04717201 0,12329048 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,05109012 0,13337943 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,05309164 0,13844759 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,05309164 0,1382908 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,0539744 0,14043112 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,0539744 0,14027244 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,0539744 0,14011412 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,0539744 0,13995616 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0539744 0,13979855 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,0539744 0,13964129 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0539744 0,13948439 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,0539744 0,13932785 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,0539744 0,13917165 ! reproductive behavior GO:0019098 12 7 0,000 0,0539744 0,1390158 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,0539744 0,1388603 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,0539744 0,13870515 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,0539744 0,13855035 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,0539744 0,13839589 ! oligopeptide transport GO:0006857 11 7 0,000 0,0539744 0,13824177 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,0539744 0,138088 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,0539744 0,13793457 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,0539744 0,13778148 ! RNA methylation GO:0001510 11 7 0,000 0,0539744 0,13762873 ! pericardium development GO:0060039 8 7 0,000 0,0539744 0,13747631 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,0539744 0,13732424 ! fibril organization GO:0043206 13 7 0,000 0,0539744 0,1371725 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,0539744 0,13702109 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,0539744 0,13687002 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,0539744 0,13671928 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,0539744 0,13656888 ! lipoprotein transport GO:0042953 9 7 0,000 0,0539744 0,1364188 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,0539744 0,13626906 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,0539744 0,13611964 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,0539744 0,13597055 ! estrogen metabolic process GO:0008210 14 7 0,000 0,0539744 0,13582178 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,0539744 0,13567334 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,0539744 0,13552523 ! chemosensory behavior GO:0007635 9 7 0,000 0,0539744 0,13537744 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,0539744 0,13522997 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,0539744 0,13508282 ! leukocyte degranulation GO:0043299 10 7 0,000 0,0539744 0,13493599 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,0539744 0,13478948 ! reflex GO:0060004 12 7 0,000 0,0539744 0,13464329 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,0539744 0,13449741 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,0539744 0,13435185 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0539744 0,13420661 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,0539744 0,13406167 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,0539744 0,13391706 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0539744 0,13377275 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,0539744 0,13362875 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,0539744 0,13348506 ! adrenal gland development GO:0030325 17 7 0,000 0,0539744 0,13334169 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,0539744 0,13319862 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,0539744 0,13305585 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,0539744 0,13291339 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,0539744 0,13277124 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,0539744 0,13262939 ! endosome organization GO:0007032 10 7 0,000 0,0539744 0,13248784 ! thyroid hormone generation GO:0006590 11 7 0,000 0,0539744 0,1323466 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,0539744 0,13220566 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,0539744 0,13206501 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,0539744 0,13192467 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0539744 0,13178462 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,0539744 0,13164487 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,0539744 0,13150541 ! galactose metabolic process GO:0006012 10 7 0,000 0,0539744 0,13136625 ! vesicle fusion GO:0006906 15 7 0,000 0,0539744 0,13122739 ! intracellular pH reduction GO:0051452 10 7 0,000 0,0539744 0,13108882 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,0539744 0,13095054 ! organ growth GO:0035265 11 7 0,000 0,0539744 0,13081255 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,0539744 0,13067485 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,0539744 0,13053745 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,0539744 0,13040033 ! retinol metabolic process GO:0042572 9 7 0,000 0,0539744 0,13026349 ! behavioral fear response GO:0001662 13 7 0,000 0,0539744 0,13012695 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,0539744 0,12999069 ! rRNA modification GO:0000154 12 7 0,000 0,0539744 0,12985472 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,0539744 0,12971903 ! response to UV-B GO:0010224 11 7 0,000 0,0539744 0,12958362 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,0539744 0,1294485 ! intermediate filament organization GO:0045109 11 7 0,000 0,0539744 0,12931366 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,0539744 0,12917909 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,0539744 0,12904481 ! fibrinolysis GO:0042730 9 7 0,000 0,0539744 0,12891081 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,0539744 0,12877709 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,0539744 0,12864364 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,0539744 0,12851047 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,0539744 0,12837757 ! response to tropane GO:0014073 13 7 0,000 0,0539744 0,12824495 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,0539744 0,1281126 ! melanosome localization GO:0032400 10 7 0,000 0,0539744 0,12798053 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,0539744 0,12784872 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,0539744 0,12771719 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,0539744 0,12758593 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,0539744 0,12745494 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,0539744 0,12732422 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,0539744 0,12719376 ! mast cell activation GO:0045576 9 7 0,000 0,0539744 0,12706357 ! multicellular organismal aging GO:0010259 11 7 0,000 0,0539744 0,12693365 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,0539744 0,12680399 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,0539744 0,1266746 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,0539744 0,12654547 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,0539744 0,12641661 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,0539744 0,12628801 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,0539744 0,12615966 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,0539744 0,12603158 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,0539744 0,12590376 ! regulation of lipid transport GO:0032368 13 7 0,000 0,0539744 0,1257762 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,0539744 0,1256489 ! neuroblast proliferation GO:0007405 13 7 0,000 0,0539744 0,12552185 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,0539744 0,12539506 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,0539744 0,12526853 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,0539744 0,12514225 ! diuresis GO:0030146 12 7 0,000 0,0539744 0,12501622 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,0539744 0,12489045 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,0539744 0,12476493 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0539744 0,12463967 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,0539744 0,12451465 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,0539744 0,12438989 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,0539744 0,12426538 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,0539744 0,12414111 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,0539744 0,12401709 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,0539744 0,12389332 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,0539744 0,1237698 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,0539744 0,12364652 ! lymph node development GO:0048535 9 7 0,000 0,0539744 0,12352349 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,0539744 0,12340071 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,0539744 0,12327816 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,0539744 0,12315586 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,0539744 0,12303381 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,0539744 0,12291199 ! ATP catabolic process GO:0006200 10 7 0,000 0,0539744 0,12279042 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,0539744 0,12266908 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,0539744 0,12254799 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,0539744 0,12242713 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,0539744 0,12230651 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,0539744 0,12218613 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,0539744 0,12206599 ! muscle adaptation GO:0043500 12 7 0,000 0,0539744 0,12194608 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,0539744 0,12182641 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,0539744 0,12170697 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,0539744 0,12158777 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,0539744 0,1214688 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,0539744 0,12135006 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,0539744 0,12123155 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,0539744 0,12111328 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,0539744 0,12099523 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,0539744 0,12087742 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,05512072 0,12332456 GO:0010952|positive regulation of peptidase activity, ! regulation of muscle contraction GO:0006937 69 48 1,000 0,05512072 0,12320471 ! regulation of endocytosis GO:0030100 63 48 1,000 0,05512072 0,1230851 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,05512072 0,12296571 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,0571768 0,12742892 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,0571768 0,12730556 ! ear development GO:0043583 72 50 1,000 0,05925935 0,13181479 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05925935 0,13168744 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,05925935 0,13156032 ! lipid modification GO:0030258 73 50 1,000 0,05925935 0,13143346 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,06136781 0,13597878 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,06136781 0,1358479 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06144516 0,13588833 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06144516 0,13575779 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,06144516 0,1356275 ! axon extension GO:0048675 11 8 0,000 0,06144516 0,13549747 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,06144516 0,13536768 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06144516 0,13523814 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06144516 0,13510885 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06144516 0,13497981 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06144516 0,13485101 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06144516 0,13472246 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,06144516 0,13459415 ! phosphate transport GO:0006817 10 8 0,000 0,06144516 0,13446609 ! N-glycan processing GO:0006491 12 8 0,000 0,06144516 0,13433827 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,06144516 0,13421069 ! UTP metabolic process GO:0046051 8 8 0,000 0,06144516 0,13408336 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06144516 0,13395626 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,06144516 0,13382941 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06144516 0,1337028 ! succinate metabolic process GO:0006105 14 8 0,000 0,06144516 0,13357643 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06144516 0,13345029 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,06144516 0,13332439 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,06144516 0,13319874 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06144516 0,13307331 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,06144516 0,13294813 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06144516 0,13282318 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06144516 0,13269846 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06144516 0,13257398 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06144516 0,13244973 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06144516 0,13232571 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06144516 0,13220193 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06144516 0,13207837 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06144516 0,13195505 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,06144516 0,13183196 ! astrocyte differentiation GO:0048708 16 8 0,000 0,06144516 0,13170909 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06144516 0,13158646 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,06144516 0,13146405 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,06144516 0,13134188 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06144516 0,13121992 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06144516 0,1310982 ! melanin metabolic process GO:0006582 12 8 0,000 0,06144516 0,1309767 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06144516 0,13085542 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,06144516 0,13073437 ! macrophage activation GO:0042116 12 8 0,000 0,06144516 0,13061355 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06144516 0,13049294 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,06144516 0,13037256 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,06144516 0,1302524 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06144516 0,13013247 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,06144516 0,13001275 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06144516 0,12989325 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06144516 0,12977397 ! ruffle organization GO:0031529 11 8 0,000 0,06144516 0,12965492 ! osteoblast development GO:0002076 13 8 0,000 0,06144516 0,12953608 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06144516 0,12941745 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06144516 0,12929905 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,06144516 0,12918086 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06144516 0,12906288 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06144516 0,12894513 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06144516 0,12882758 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06144516 0,12871025 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06144516 0,12859314 ! brain morphogenesis GO:0048854 20 8 0,000 0,06144516 0,12847624 ! oligodendrocyte development GO:0014003 8 8 0,000 0,06144516 0,12835954 ! cellular extravasation GO:0045123 11 8 0,000 0,06144516 0,12824307 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06144516 0,1281268 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06144516 0,12801074 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06144516 0,12789489 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06144516 0,12777926 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06144516 0,12766383 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06144516 0,12754861 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06144516 0,1274336 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06144516 0,12731879 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,06144516 0,12720419 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06144516 0,1270898 ! icosanoid secretion GO:0032309 12 8 0,000 0,06144516 0,12697561 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06144516 0,12686163 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06144516 0,12674786 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06144516 0,12663428 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06144516 0,12652091 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06144516 0,12640774 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06144516 0,12629478 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06144516 0,12618202 ! sterol catabolic process GO:0016127 9 8 0,000 0,06144516 0,12606945 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06144516 0,12595709 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06144516 0,12584493 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06144516 0,12573297 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06144516 0,12562121 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06144516 0,12550964 ! prophase GO:0051324 11 8 0,000 0,06144516 0,12539828 ! S phase GO:0051320 8 8 0,000 0,06144516 0,12528711 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06144516 0,12517614 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,06144516 0,12506536 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06144516 0,12495478 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06144516 0,1248444 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06144516 0,12473421 ! hormone catabolic process GO:0042447 13 8 0,000 0,06144516 0,12462421 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06144516 0,12451441 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06144516 0,12440481 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06144516 0,12429539 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06144516 0,12418617 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,06144516 0,12407714 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06144516 0,1239683 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06144516 0,12385965 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06144516 0,12375119 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06144516 0,12364292 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,06144516 0,12353484 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06144516 0,12342695 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06144516 0,12331925 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06144516 0,12321173 ! transition metal ion transport GO:0000041 74 52 1,000 0,06350167 0,1272246 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,06350167 0,12711387 ! cell projection assembly GO:0030031 76 53 1,000 0,06566039 0,13132078 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,06784346 0,13556902 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,06784346 0,13545134 ! DNA catabolic process GO:0006308 67 54 1,000 0,06784346 0,13533387 ! detection of external stimulus GO:0009581 66 54 1,000 0,06784346 0,13521659 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,06784346 0,13509952 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06885734 0,13699991 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06885734 0,1368815 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06885734 0,13676329 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06885734 0,13664529 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06885734 0,13652749 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06885734 0,1364099 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06885734 0,1362925 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06885734 0,13617531 ! GTP metabolic process GO:0046039 9 9 0,000 0,06885734 0,13605833 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06885734 0,13594154 ! social behavior GO:0035176 14 9 0,000 0,06885734 0,13582495 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06885734 0,13570856 ! artery development GO:0060840 19 9 0,000 0,06885734 0,13559237 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06885734 0,13547638 ! response to pain GO:0048265 16 9 0,000 0,06885734 0,13536059 ! protein complex disassembly GO:0043241 17 9 0,000 0,06885734 0,135245 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06885734 0,1351296 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06885734 0,1350144 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06885734 0,1348994 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06885734 0,13478459 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06885734 0,13466997 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06885734 0,13455556 ! protein targeting to ER GO:0045047 19 9 0,000 0,06885734 0,13444133 ! T cell selection GO:0045058 18 9 0,000 0,06885734 0,1343273 ! endoderm development GO:0007492 12 9 0,000 0,06885734 0,13421347 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06885734 0,13409982 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06885734 0,13398637 ! arginine catabolic process GO:0006527 10 9 0,000 0,06885734 0,13387311 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06885734 0,13376004 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06885734 0,13364716 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06885734 0,13353448 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06885734 0,13342198 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06885734 0,13330967 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06885734 0,13319755 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06885734 0,13308562 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06885734 0,13297388 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06885734 0,13286232 ! mannose metabolic process GO:0006013 9 9 0,000 0,06885734 0,13275096 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06885734 0,13263977 ! receptor clustering GO:0043113 15 9 0,000 0,06885734 0,13252878 ! epithelial cell development GO:0002064 10 9 0,000 0,06885734 0,13241797 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06885734 0,13230734 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06885734 0,1321969 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06885734 0,13208665 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06885734 0,13197658 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06885734 0,13186669 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06885734 0,13175698 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06885734 0,13164746 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06885734 0,13153811 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06885734 0,13142895 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06885734 0,13131998 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06885734 0,13121118 ! response to amine stimulus GO:0014075 13 9 0,000 0,06885734 0,13110256 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06885734 0,13099412 ! erythrocyte development GO:0048821 11 9 0,000 0,06885734 0,13088586 ! renal water homeostasis GO:0003091 14 9 0,000 0,06885734 0,13077778 ! postreplication repair GO:0006301 11 9 0,000 0,06885734 0,13066988 ! mRNA cleavage GO:0006379 13 9 0,000 0,06885734 0,13056215 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06885734 0,1304546 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06885734 0,13034723 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06885734 0,13024004 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06885734 0,13013302 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06885734 0,13002618 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06885734 0,12991952 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06885734 0,12981302 ! acid secretion GO:0046717 14 9 0,000 0,06885734 0,12970671 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06885734 0,12960056 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06885734 0,1294946 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06885734 0,1293888 ! purine base metabolic process GO:0006144 18 9 0,000 0,06885734 0,12928318 ! oocyte differentiation GO:0009994 12 9 0,000 0,06885734 0,12917772 GO:0048599|oocyte development, ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06885734 0,12907245 ! spleen development GO:0048536 15 9 0,000 0,06885734 0,12896734 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06885734 0,1288624 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06885734 0,12875763 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06885734 0,12865304 ! detection of calcium ion GO:0005513 13 9 0,000 0,06885734 0,12854861 ! blastocyst formation GO:0001825 12 9 0,000 0,06885734 0,12844436 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06885734 0,12834027 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06885734 0,12823635 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06885734 0,1281326 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06885734 0,12802901 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06885734 0,1279256 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06885734 0,12782235 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06885734 0,12771927 ! prepulse inhibition GO:0060134 14 9 0,000 0,06885734 0,12761635 ! embryonic placenta development GO:0001892 12 9 0,000 0,06885734 0,1275136 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06885734 0,12741101 ! insulin secretion GO:0030073 17 9 0,000 0,06885734 0,12730859 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06885734 0,12720634 ! response to nicotine GO:0035094 16 9 0,000 0,06885734 0,12710425 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06885734 0,12700232 ! nucleus localization GO:0051647 15 9 0,000 0,06885734 0,12690055 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06885734 0,12679895 ! mesoderm development GO:0007498 76 55 1,000 0,07005035 0,12889265 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,07228058 0,13288995 ! carbohydrate transport GO:0008643 74 57 1,000 0,07453363 0,13692281 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,07453363 0,13681353 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 1,000 0,07453363 0,13670443 ! camera-type eye development GO:0043010 88 57 1,000 0,07453363 0,1365955 ! developmental maturation GO:0021700 75 57 1,000 0,07453363 0,13648675 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07621141 0,13944809 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07621141 0,13933724 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07621141 0,13922657 ! thyroid gland development GO:0030878 19 10 0,000 0,07621141 0,13911607 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,07621141 0,13900575 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07621141 0,13889561 ! synapsis GO:0007129 13 10 0,000 0,07621141 0,13878563 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07621141 0,13867583 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07621141 0,13856621 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07621141 0,13845676 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07621141 0,13834748 ! sulfate transport GO:0008272 12 10 0,000 0,07621141 0,13823837 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07621141 0,13812944 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07621141 0,13802067 ! androgen metabolic process GO:0008209 13 10 0,000 0,07621141 0,13791208 ! phospholipid efflux GO:0033700 16 10 0,000 0,07621141 0,13780366 ! hippocampus development GO:0021766 19 10 0,000 0,07621141 0,13769541 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,07621141 0,13758733 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07621141 0,13747942 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07621141 0,13737167 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,07621141 0,1372641 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07621141 0,13715669 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07621141 0,13704946 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07621141 0,13694239 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07621141 0,13683548 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07621141 0,13672875 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07621141 0,13662218 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07621141 0,13651577 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07621141 0,13640954 ! B cell proliferation GO:0042100 14 10 0,000 0,07621141 0,13630346 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07621141 0,13619756 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07621141 0,13609181 ! forebrain cell migration GO:0021885 17 10 0,000 0,07621141 0,13598623 ! lipid digestion GO:0044241 15 10 0,000 0,07621141 0,13588082 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07621141 0,13577556 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07621141 0,13567048 ! UV protection GO:0009650 14 10 0,000 0,07621141 0,13556555 ! entry into host cell GO:0030260 20 10 0,000 0,07621141 0,13546078 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07621141 0,13535618 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07621141 0,13525174 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07621141 0,13514746 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07621141 0,13504334 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07621141 0,13493938 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07621141 0,13483558 ! response to dsRNA GO:0043331 18 10 0,000 0,07621141 0,13473194 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07621141 0,13462846 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07621141 0,13452514 ! embryonic axis specification GO:0000578 12 10 0,000 0,07621141 0,13442197 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07621141 0,13431897 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07621141 0,13421612 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07621141 0,13411343 ! fucose catabolic process GO:0019317 16 10 0,000 0,07621141 0,1340109 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07621141 0,13390852 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07621141 0,1338063 ! protein sumoylation GO:0016925 12 10 0,000 0,07621141 0,13370424 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07621141 0,13360233 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07621141 0,13350057 ! zymogen activation GO:0031638 14 10 0,000 0,07621141 0,13339898 ! salivary gland development GO:0007431 22 10 0,000 0,07621141 0,13329753 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07621141 0,13319624 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07621141 0,13309511 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07621141 0,13299412 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07621141 0,13289329 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07621141 0,13279262 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07621141 0,13269209 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07621141 0,13259172 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07621141 0,1324915 ! detection of bacterium GO:0016045 10 10 0,000 0,07621141 0,13239143 ! activation of innate immune response GO:0002218 10 10 0,000 0,07621141 0,13229151 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07621141 0,13219175 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07621141 0,13209213 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,07621141 0,13199266 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07621141 0,13189334 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07621141 0,13179418 ! steroid hormone receptor signaling pathway GO:0030518 96 58 1,000 0,07680902 0,13272783 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,07910625 0,13659488 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,07910625 0,13649241 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,08142485 0,14038768 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,08142485 0,14028252 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,08142485 0,14017752 ! rRNA transcription GO:0009303 17 11 0,000 0,08350782 0,14365594 ! respiratory burst GO:0045730 14 11 0,000 0,08350782 0,14354857 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,08350782 0,14344137 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,08350782 0,14333432 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,08350782 0,14322744 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,08350782 0,14312071 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,08350782 0,14301414 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08350782 0,14290773 ! mating GO:0007618 14 11 0,000 0,08350782 0,14280148 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,08350782 0,14269539 ! T cell proliferation GO:0042098 20 11 0,000 0,08350782 0,14258945 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,08350782 0,14248367 ! bone resorption GO:0045453 16 11 0,000 0,08350782 0,14237805 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08350782 0,14227259 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08350782 0,14216728 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,08350782 0,14206212 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,08350782 0,14195713 ! syncytium formation GO:0006949 15 11 0,000 0,08350782 0,14185228 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08350782 0,14174759 ! focal adhesion formation GO:0048041 24 11 0,000 0,08350782 0,14164306 ! mitotic spindle organization GO:0007052 15 11 0,000 0,08350782 0,14153868 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,08350782 0,14143446 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,08350782 0,14133038 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08350782 0,14122646 ! adult heart development GO:0007512 11 11 0,000 0,08350782 0,1411227 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,08350782 0,14101908 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,08350782 0,14091562 ! temperature homeostasis GO:0001659 16 11 0,000 0,08350782 0,14081231 ! L-glutamate transport GO:0015813 16 11 0,000 0,08350782 0,14070915 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,08350782 0,14060614 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08350782 0,14050328 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08350782 0,14040058 ! stem cell development GO:0048864 29 11 0,000 0,08350782 0,14029802 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08350782 0,14019561 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08350782 0,14009336 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08350782 0,13999125 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,08350782 0,13988929 ! vasoconstriction GO:0042310 15 11 0,000 0,08350782 0,13978747 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08350782 0,13968581 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08350782 0,1395843 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08350782 0,13948293 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,08350782 0,13938171 ! ribosome assembly GO:0042255 13 11 0,000 0,08350782 0,13928063 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,08350782 0,1391797 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,08350782 0,13907892 ! chromatin silencing GO:0006342 19 11 0,000 0,08350782 0,13897829 ! nucleosome positioning GO:0016584 13 11 0,000 0,08350782 0,13887779 ! regulation of isotype switching GO:0045191 19 11 0,000 0,08350782 0,13877745 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08350782 0,13867725 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,08350782 0,13857719 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08350782 0,13847728 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,08350782 0,13837751 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08350782 0,13827789 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08350782 0,13817841 ! male genitalia development GO:0030539 13 11 0,000 0,08350782 0,13807907 ! cholesterol efflux GO:0033344 19 11 0,000 0,08350782 0,13797988 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08350782 0,13788083 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,08350782 0,13778192 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,08350782 0,13768315 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,08350782 0,13758452 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08350782 0,13748603 ! defense response to fungus GO:0050832 12 11 0,000 0,08350782 0,13738769 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08350782 0,13728949 ! lysogeny GO:0030069 18 11 0,000 0,08350782 0,13719142 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08350782 0,1370935 ! acrosome reaction GO:0007340 13 11 0,000 0,08350782 0,13699571 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,08376435 0,1373186 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,08376435 0,1372208 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,08612426 0,14098634 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,08612426 0,14088607 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,08850414 0,14467628 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,08850414 0,14457353 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 1,000 0,08850414 0,14447092 ! regulation of lipase activity GO:0060191 109 63 1,000 0,08850414 0,14436846 ! lactation GO:0007595 20 12 0,000 0,09074701 0,14792213 ! reproductive cellular process GO:0048610 14 12 0,000 0,09074701 0,14781737 ! tRNA modification GO:0006400 14 12 0,000 0,09074701 0,14771276 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,09074701 0,1476083 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,09074701 0,14750398 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,09074701 0,14739981 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,09074701 0,14729579 ! non-recombinational repair GO:0000726 19 12 0,000 0,09074701 0,14719191 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,09074701 0,14708818 ! peroxisomal transport GO:0043574 21 12 0,000 0,09074701 0,1469846 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,09074701 0,14688116 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,09074701 0,14677787 ! heart looping GO:0001947 15 12 0,000 0,09074701 0,14667472 ! palate development GO:0060021 15 12 0,000 0,09074701 0,14657172 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,09074701 0,14646886 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,09074701 0,14636615 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,09074701 0,14626358 ! arginine metabolic process GO:0006525 13 12 0,000 0,09074701 0,14616116 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,09074701 0,14605887 ! methionine metabolic process GO:0006555 13 12 0,000 0,09074701 0,14595674 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,09074701 0,14585474 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,09074701 0,14575289 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,09074701 0,14565117 ! monoamine transport GO:0015844 13 12 0,000 0,09074701 0,1455496 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,09074701 0,14544818 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,09074701 0,14534689 ! L-amino acid transport GO:0015807 20 12 0,000 0,09074701 0,14524574 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,09074701 0,14514474 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,09074701 0,14504387 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,09074701 0,14494315 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,09074701 0,14484256 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,09074701 0,14474212 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,09074701 0,14464181 ! cerebellum development GO:0021549 13 12 0,000 0,09074701 0,14454164 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,09074701 0,14444161 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,09074701 0,14434172 ! histone methylation GO:0016571 15 12 0,000 0,09074701 0,14424197 ! gland morphogenesis GO:0022612 23 12 0,000 0,09074701 0,14414236 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,09074701 0,14404288 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,09074701 0,14394354 ! regulation of epidermis development GO:0045682 17 12 0,000 0,09074701 0,14384434 ! intestinal absorption GO:0050892 19 12 0,000 0,09074701 0,14374527 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,09074701 0,14364634 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,09074701 0,14354755 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,09074701 0,14344889 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,09074701 0,14335037 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,09074701 0,14325198 ! microspike assembly GO:0030035 23 12 0,000 0,09074701 0,14315373 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,09074701 0,14305561 ! response to cold GO:0009409 14 12 0,000 0,09074701 0,14295762 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,09090352 0,14310616 ! neuropeptide signaling pathway GO:0007218 79 64 1,000 0,09090352 0,14300828 ! adaptive immune response GO:0002250 94 64 1,000 0,09090352 0,14291053 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 1,000 0,09332196 0,14661237 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,09332196 0,14651229 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,09332196 0,14641235 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,095759 0,15013341 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,095759 0,15003114 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09792944 0,15332723 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09792944 0,15322293 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09792944 0,15311876 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,09792944 0,15301474 ! water transport GO:0006833 17 13 0,000 0,09792944 0,15291086 GO:0042044|fluid transport, ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09792944 0,15280713 ! lipid localization GO:0010876 24 13 0,000 0,09792944 0,15270353 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09792944 0,15260007 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09792944 0,15249675 ! organelle fusion GO:0048284 28 13 0,000 0,09792944 0,15239357 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09792944 0,15229054 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09792944 0,15218764 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,09792944 0,15208488 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09792944 0,15198226 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09792944 0,15187977 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,09792944 0,15177743 ! glutamate metabolic process GO:0006536 18 13 0,000 0,09792944 0,15167522 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09792944 0,15157315 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09792944 0,15147122 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09792944 0,15136942 ! NAD metabolic process GO:0019674 21 13 0,000 0,09792944 0,15126777 ! exocrine system development GO:0035272 27 13 0,000 0,09792944 0,15116624 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,09792944 0,15106486 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09792944 0,15096361 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09792944 0,15086249 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09792944 0,15076151 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09792944 0,15066067 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,09792944 0,15055996 ! genitalia development GO:0048806 15 13 0,000 0,09792944 0,15045939 ! cellular pigmentation GO:0033059 24 13 0,000 0,09792944 0,15035895 ! tissue regeneration GO:0042246 21 13 0,000 0,09792944 0,15025864 ! cofactor transport GO:0051181 19 13 0,000 0,09792944 0,15015847 ! NADP metabolic process GO:0006739 18 13 0,000 0,09792944 0,15005843 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09792944 0,14995852 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09792944 0,14985875 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09792944 0,14975911 ! gas transport GO:0015669 18 13 0,000 0,09792944 0,1496596 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09792944 0,14956023 ! regulation of axon extension GO:0030516 23 13 0,000 0,09792944 0,14946098 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09792944 0,14936187 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09792944 0,14926289 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09792944 0,14916404 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09792944 0,14906532 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09792944 0,14896673 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,10068717 0,15306047 ! rhythmic process GO:0048511 105 68 1,000 0,10068717 0,15295937 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,10317743 0,156639 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,10505553 0,15938504 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,10505553 0,15927997 ! neuron maturation GO:0042551 21 14 0,000 0,10505553 0,15917505 ! regulation of S phase GO:0033261 18 14 0,000 0,10505553 0,15907026 ! myotube differentiation GO:0014902 21 14 0,000 0,10505553 0,1589656 ! inositol metabolic process GO:0006020 20 14 0,000 0,10505553 0,15886109 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,10505553 0,15875671 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,10505553 0,15865247 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,10505553 0,15854837 ! gene silencing by RNA GO:0031047 20 14 0,000 0,10505553 0,15844441 ! response to cAMP GO:0051591 19 14 0,000 0,10505553 0,15834058 ! limbic system development GO:0021761 25 14 0,000 0,10505553 0,15823688 ! startle response GO:0001964 21 14 0,000 0,10505553 0,15813332 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,10505553 0,1580299 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,10505553 0,15792661 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,10505553 0,15782346 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,10505553 0,15772044 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,10505553 0,15761756 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,10505553 0,15751481 ! glycine metabolic process GO:0006544 22 14 0,000 0,10505553 0,15741219 ! pituitary gland development GO:0021983 23 14 0,000 0,10505553 0,15730971 ! lysosomal transport GO:0007041 20 14 0,000 0,10505553 0,15720736 ! regulation of heart rate GO:0002027 23 14 0,000 0,10505553 0,15710515 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,10505553 0,15700307 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,10505553 0,15690112 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,10505553 0,1567993 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,10505553 0,15669761 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,10505553 0,15659606 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10505553 0,15649464 ! mRNA splice site selection GO:0006376 26 14 0,000 0,10505553 0,15639335 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,10505553 0,15629219 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,10505553 0,15619116 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,10505553 0,15609026 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,10505553 0,15598949 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,10505553 0,15588885 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,10505553 0,15578834 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,10505553 0,15568796 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,10505553 0,15558771 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,10505553 0,15548759 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,10505553 0,1553876 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,10505553 0,15528774 ! cell killing GO:0001906 20 14 0,000 0,10505553 0,155188 ! cilium assembly GO:0042384 20 14 0,000 0,10505553 0,15508839 ! peptide hormone secretion GO:0030072 23 14 0,000 0,10505553 0,15498892 ! response to metal ion GO:0010038 103 70 1,000 0,10568457 0,155817 ! eye development GO:0001654 111 70 1,000 0,10568457 0,15571718 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,10568457 0,15561749 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,10820818 0,15923149 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,10820818 0,15912968 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,11074786 0,16276043 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,11074786 0,16265649 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,11212573 0,16457511 ! metencephalon development GO:0022037 19 15 0,000 0,11212573 0,16447015 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,11212573 0,16436532 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,11212573 0,16426063 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,11212573 0,16415607 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,11212573 0,16405165 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,11212573 0,16394736 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,11212573 0,1638432 ! bile acid metabolic process GO:0008206 22 15 0,000 0,11212573 0,16373917 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,11212573 0,16363527 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,11212573 0,16353151 ! adult walking behavior GO:0007628 25 15 0,000 0,11212573 0,16342788 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,11212573 0,16332438 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,11212573 0,16322101 ! myoblast differentiation GO:0045445 27 15 0,000 0,11212573 0,16311777 ! centrosome cycle GO:0007098 16 15 0,000 0,11212573 0,16301466 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,11212573 0,16291168 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,11212573 0,16280883 ! cerebral cortex development GO:0021987 29 15 0,000 0,11212573 0,16270611 ! response to osmotic stress GO:0006970 22 15 0,000 0,11212573 0,16260352 ! vesicle coating GO:0006901 25 15 0,000 0,11212573 0,16250106 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,11212573 0,16239873 ! DNA integration GO:0015074 22 15 0,000 0,11212573 0,16229653 ! peptide secretion GO:0002790 27 15 0,000 0,11212573 0,16219446 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,11212573 0,16209251 ! regulation of vasodilation GO:0042312 24 15 0,000 0,11212573 0,1619907 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,11212573 0,16188901 ! neuron recognition GO:0008038 22 15 0,000 0,11212573 0,16178745 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,11212573 0,16168601 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,11212573 0,16158471 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,11212573 0,16148353 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,11212573 0,16138247 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,11212573 0,16128154 ! dopamine metabolic process GO:0042417 30 15 0,000 0,11212573 0,16118074 ! organic cation transport GO:0015695 19 15 0,000 0,11212573 0,16108007 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,11212573 0,16097952 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,11212573 0,1608791 ! defense response to virus GO:0051607 27 15 0,000 0,11212573 0,1607788 ! peptide hormone processing GO:0016486 19 15 0,000 0,11212573 0,16067862 ! regulation of blood pressure GO:0008217 107 73 1,000 0,11330318 0,16226482 ! negative regulation of transport GO:0051051 116 73 1,000 0,11330318 0,16216385 ! response to inorganic substance GO:0010035 115 75 1,000 0,11845918 0,16943788 ! negative regulation of growth GO:0045926 123 75 1,000 0,11845918 0,16933258 ! regulation of ligase activity GO:0051340 114 75 1,000 0,11845918 0,1692274 ! protein secretion GO:0009306 27 16 0,000 0,11914049 0,17009504 ! hormone secretion GO:0046879 25 16 0,000 0,11914049 0,16998953 ! bone remodeling GO:0046849 24 16 0,000 0,11914049 0,16988414 ! endothelial cell migration GO:0043542 22 16 0,000 0,11914049 0,16977888 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11914049 0,16967376 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11914049 0,16956876 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11914049 0,16946389 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11914049 0,16935916 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11914049 0,16925455 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11914049 0,16915007 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11914049 0,16904572 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11914049 0,1689415 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11914049 0,16883741 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11914049 0,16873345 ! fructose metabolic process GO:0006000 20 16 0,000 0,11914049 0,16862961 ! regulation of protein binding GO:0043393 27 16 0,000 0,11914049 0,1685259 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11914049 0,16842232 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11914049 0,16831887 ! protein export from nucleus GO:0006611 24 16 0,000 0,11914049 0,16821554 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11914049 0,16811234 ! DNA replication initiation GO:0006270 25 16 0,000 0,11914049 0,16800927 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11914049 0,16790632 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11914049 0,1678035 ! diencephalon development GO:0021536 25 16 0,000 0,11914049 0,16770081 ! oogenesis GO:0048477 23 16 0,000 0,11914049 0,16759824 ! neural crest cell migration GO:0001755 24 16 0,000 0,11914049 0,16749579 ! G1 phase GO:0051318 27 16 0,000 0,11914049 0,16739347 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,11914049 0,16729128 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11914049 0,16718921 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11914049 0,16708727 ! steroid catabolic process GO:0006706 22 16 0,000 0,11914049 0,16698545 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11914049 0,16688375 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11914049 0,16678218 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11914049 0,16668073 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11914049 0,1665794 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11914049 0,1664782 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11914049 0,16637712 ! negative regulation of translation GO:0017148 22 16 0,000 0,11914049 0,16627616 ! tRNA metabolic process GO:0006399 95 76 1,000 0,12105907 0,16885135 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,12105907 0,16874901 ! regulation of DNA binding GO:0051101 119 77 1,000 0,12367305 0,17228832 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,12367305 0,17218403 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,12610021 0,17545704 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,12610021 0,17535096 ! negative regulation of defense response GO:0031348 19 17 0,000 0,12610021 0,17524501 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,12610021 0,17513919 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,12610021 0,17503349 ! glycerol metabolic process GO:0006071 20 17 0,000 0,12610021 0,17492792 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,12610021 0,17482248 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,12610021 0,17471716 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,12610021 0,17461198 ! signal complex assembly GO:0007172 29 17 0,000 0,12610021 0,17450691 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,12610021 0,17440198 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,12610021 0,17429717 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,12610021 0,17419249 ! memory GO:0007613 25 17 0,000 0,12610021 0,17408793 ! keratinization GO:0031424 17 17 0,000 0,12610021 0,1739835 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,12610021 0,17387919 ! retinoid metabolic process GO:0001523 22 17 0,000 0,12610021 0,17377501 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,12610021 0,17367095 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,12610021 0,17356702 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,12610021 0,17346321 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,12610021 0,17335953 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,12610021 0,17325597 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,12610021 0,17315253 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,12610021 0,17304922 ! membrane budding GO:0006900 29 17 0,000 0,12610021 0,17294603 ! heme metabolic process GO:0042168 27 17 0,000 0,12610021 0,17284296 ! actin filament bundle formation GO:0051017 26 17 0,000 0,12610021 0,17274002 ! body fluid secretion GO:0007589 27 17 0,000 0,12610021 0,1726372 ! stem cell differentiation GO:0048863 36 17 0,000 0,12610021 0,1725345 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,12610021 0,17243192 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,12610021 0,17232947 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,12610021 0,17222713 ! sensory perception of pain GO:0019233 23 17 0,000 0,12610021 0,17212492 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,12610021 0,17202283 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,12610021 0,17192086 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,12610021 0,17181901 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,12610021 0,17171728 ! cell-cell junction organization GO:0045216 25 17 0,000 0,12610021 0,17161568 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,12610021 0,17151419 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,12610021 0,17141282 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,12610021 0,17131157 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,12610021 0,17121044 ! T cell activation GO:0042110 134 79 1,000 0,12894173 0,17496517 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,13159568 0,17846113 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 1,000 0,13159568 0,17835596 ! forebrain development GO:0030900 131 80 1,000 0,13159568 0,17825092 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,13300535 0,18005433 ! positive regulation of translation GO:0045727 28 18 0,000 0,13300535 0,17994841 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,13300535 0,17984262 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,13300535 0,17973696 ! cAMP metabolic process GO:0046058 33 18 0,000 0,13300535 0,17963142 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,13300535 0,179526 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,13300535 0,1794207 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,13300535 0,17931553 ! axis specification GO:0009798 26 18 0,000 0,13300535 0,17921049 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,13300535 0,17910556 GO:0050886|endocrine process, ! pancreas development GO:0031016 26 18 0,000 0,13300535 0,17900076 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,13300535 0,17889608 ! glutamine metabolic process GO:0006541 23 18 0,000 0,13300535 0,17879153 ! response to retinoic acid GO:0032526 25 18 0,000 0,13300535 0,17868709 ! pigmentation during development GO:0048066 31 18 0,000 0,13300535 0,17858278 ! central nervous system neuron development GO:0021954 30 18 0,000 0,13300535 0,17847859 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,13300535 0,17837452 ! fucose metabolic process GO:0006004 26 18 0,000 0,13300535 0,17827057 ! response to fungus GO:0009620 19 18 0,000 0,13300535 0,17816674 ! peptide cross-linking GO:0018149 31 18 0,000 0,13300535 0,17806304 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,13300535 0,17795945 ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,13300535 0,17785599 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,13300535 0,17775264 ! visual learning GO:0008542 35 18 0,000 0,13300535 0,17764942 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,13300535 0,17754631 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,13300535 0,17744333 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,13300535 0,17734046 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,13300535 0,17723772 ! vitamin transport GO:0051180 24 18 0,000 0,13300535 0,17713509 ! hormone transport GO:0009914 27 18 0,000 0,13300535 0,17703258 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,13300535 0,17693019 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,13300535 0,17682792 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,13300535 0,17672577 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,13300535 0,17662373 ! cell-cell recognition GO:0009988 20 18 0,000 0,13300535 0,17652181 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,13300535 0,17642001 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,13300535 0,17631833 ! regulation of glucose import GO:0046324 21 18 0,000 0,13300535 0,17621676 GO:0010827|regulation of glucose transport, ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,13300535 0,17611531 ! mRNA transport GO:0051028 121 81 1,000 0,13426223 0,17767729 ! detection of stimulus GO:0051606 108 82 1,000 0,13694101 0,18111807 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,13963166 0,18457059 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13985631 0,18476136 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13985631 0,18465529 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,13985631 0,18454935 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,13985631 0,18444353 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,13985631 0,18433783 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13985631 0,18423226 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13985631 0,1841268 ! regeneration GO:0031099 32 19 0,000 0,13985631 0,18402146 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13985631 0,18391625 ! response to alkaloid GO:0043279 32 19 0,000 0,13985631 0,18381115 ! sensory perception of taste GO:0050909 23 19 0,000 0,13985631 0,18370618 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,13985631 0,18360132 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13985631 0,18349659 ! peroxisome organization GO:0007031 29 19 0,000 0,13985631 0,18339197 ! digestive system process GO:0022600 30 19 0,000 0,13985631 0,18328748 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,13985631 0,1831831 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13985631 0,18307884 ! response to vitamin A GO:0033189 26 19 0,000 0,13985631 0,1829747 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13985631 0,18287068 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13985631 0,18276677 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13985631 0,18266299 ! plasma membrane fusion GO:0045026 23 19 0,000 0,13985631 0,18255932 ! cytolysis GO:0019835 20 19 0,000 0,13985631 0,18245577 ! renal system process GO:0003014 35 19 0,000 0,13985631 0,18235234 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13985631 0,18224902 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13985631 0,18214582 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,13985631 0,18204274 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,13985631 0,18193977 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13985631 0,18183693 ! sarcomere organization GO:0045214 23 19 0,000 0,13985631 0,18173419 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13985631 0,18163158 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13985631 0,18152907 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13985631 0,18142669 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13985631 0,18132442 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,13985631 0,18122227 ! protein stabilization GO:0050821 26 19 0,000 0,13985631 0,18112023 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,1450472 0,18773694 ! rRNA metabolic process GO:0016072 107 85 1,000 0,1450472 0,18763136 GO:0006364|rRNA processing, ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,14665353 0,18960266 ! iron ion transport GO:0006826 37 20 0,000 0,14665353 0,18949614 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,14665353 0,18938974 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,14665353 0,18928346 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,14665353 0,1891773 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,14665353 0,18907126 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,14665353 0,18896534 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,14665353 0,18885953 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,14665353 0,18875385 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,14665353 0,18864828 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,14665353 0,18854283 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,14665353 0,1884375 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,14665353 0,18833229 ! pallium development GO:0021543 38 20 0,000 0,14665353 0,18822719 ! DNA modification GO:0006304 28 20 0,000 0,14665353 0,18812221 ! collagen fibril organization GO:0030199 45 20 0,000 0,14665353 0,18801735 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,14665353 0,1879126 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,14665353 0,18780798 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,14665353 0,18770346 ! collagen catabolic process GO:0030574 25 20 0,000 0,14665353 0,18759907 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,14665353 0,18749479 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,14665353 0,18739062 ! alditol metabolic process GO:0019400 24 20 0,000 0,14665353 0,18728658 ! actin filament-based movement GO:0030048 34 20 0,000 0,14665353 0,18718264 ! female pregnancy GO:0007565 130 87 1,000 0,15050609 0,19199334 ! establishment of RNA localization GO:0051236 128 88 1,000 0,15325095 0,19538647 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,15339742 0,19546486 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,15339742 0,19535663 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,15339742 0,19524852 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,15339742 0,19514053 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,15339742 0,19503265 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,15339742 0,1949249 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,15339742 0,19481727 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,15339742 0,19470975 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,15339742 0,19460236 ! vesicle docking GO:0048278 27 21 0,000 0,15339742 0,19449508 ! phototransduction GO:0007602 25 21 0,000 0,15339742 0,19438792 ! visual behavior GO:0007632 39 21 0,000 0,15339742 0,19428088 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,15339742 0,19417395 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,15339742 0,19406715 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,15339742 0,19396046 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,15339742 0,19385389 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,15339742 0,19374743 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,15339742 0,19364109 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,15339742 0,19353487 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,15339742 0,19342877 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,15339742 0,19332278 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,15339742 0,19321691 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,15339742 0,19311115 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,15339742 0,19300551 ! fatty acid transport GO:0015908 30 21 0,000 0,15339742 0,19289998 ! immunoglobulin production GO:0002377 33 21 0,000 0,15339742 0,19279457 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,15339742 0,19268928 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,15339742 0,1925841 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,15339742 0,19247903 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,15339742 0,19237408 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,15339742 0,19226925 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,15339742 0,19216453 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,15339742 0,19205992 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,15339742 0,19195542 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,15339742 0,19185104 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,15339742 0,19174678 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,15339742 0,19164262 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,15339742 0,19153858 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,15339742 0,19143466 ! leukocyte differentiation GO:0002521 143 90 1,000 0,15876989 0,19803185 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,1600884 0,19956819 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,1600884 0,19946009 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,1600884 0,19935209 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,1600884 0,19924422 ! leukocyte adhesion GO:0007159 38 22 0,000 0,1600884 0,19913646 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,1600884 0,19902882 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,1600884 0,1989213 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,1600884 0,19881389 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,1600884 0,19870659 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,1600884 0,19859942 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,1600884 0,19849236 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,1600884 0,19838541 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,1600884 0,19827858 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,1600884 0,19817186 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,1600884 0,19806526 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,1600884 0,19795877 ! membrane depolarization GO:0051899 35 22 0,000 0,1600884 0,1978524 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,1600884 0,19774614 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,1600884 0,19764 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,1600884 0,19753397 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,1600884 0,19742805 ! blastocyst development GO:0001824 37 22 0,000 0,1600884 0,19732225 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,1600884 0,19721656 ! RNA localization GO:0006403 135 91 1,000 0,16154331 0,19890237 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,16432563 0,20221987 ! sulfur metabolic process GO:0006790 118 92 1,000 0,16432563 0,20211173 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,16672688 0,20495554 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,16672688 0,20484606 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,16672688 0,20473669 ! vesicle targeting GO:0006903 32 23 0,000 0,16672688 0,20462744 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,16672688 0,2045183 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,16672688 0,20440928 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,16672688 0,20430038 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,16672688 0,20419159 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,16672688 0,20408292 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,16672688 0,20397437 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,16672688 0,20386593 ! cell fate determination GO:0001709 45 23 0,000 0,16672688 0,20375761 ! pentose metabolic process GO:0019321 31 23 0,000 0,16672688 0,2036494 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,16672688 0,2035413 ! spermatid development GO:0007286 33 23 0,000 0,16672688 0,20343332 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,16672688 0,20332546 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,16672688 0,20321771 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,16672688 0,20311007 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,16672688 0,20300255 ! telomere organization GO:0032200 32 23 0,000 0,16672688 0,20289514 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,16672688 0,20278785 ! regulation of amine transport GO:0051952 38 23 0,000 0,16672688 0,20268066 ! liver development GO:0001889 40 23 0,000 0,16672688 0,20257359 ! response to oxidative stress GO:0006979 141 94 1,000 0,16991568 0,20633899 ! regulation of binding GO:0051098 151 95 1,000 0,17272281 0,20963718 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,17331326 0,21024288 ! initiation of viral infection GO:0019059 42 24 0,000 0,17331326 0,21013205 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,17331326 0,21002134 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,17331326 0,20991074 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,17331326 0,20980026 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,17331326 0,2096899 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,17331326 0,20957965 ! sperm motility GO:0030317 27 24 0,000 0,17331326 0,20946952 ! vacuole organization GO:0007033 39 24 0,000 0,17331326 0,20935951 ! receptor metabolic process GO:0043112 37 24 0,000 0,17331326 0,20924961 ! neural crest cell development GO:0014032 39 24 0,000 0,17331326 0,20913982 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,17331326 0,20903015 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,17331326 0,2089206 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,17331326 0,20881116 GO:0002708|positive regulation of lymphocyte mediated immunity, ! neurotransmitter secretion GO:0007269 32 24 0,000 0,17331326 0,20870183 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,17331326 0,20859262 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,17553761 0,21115926 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,17553761 0,21104888 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,17984796 0,21611824 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17984796 0,21600538 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17984796 0,21589264 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17984796 0,21578002 GO:0006479|protein amino acid methylation, ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,17984796 0,21566752 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17984796 0,21555514 ! peptide transport GO:0015833 43 25 0,000 0,17984796 0,21544287 ! male gonad development GO:0008584 33 25 0,000 0,17984796 0,21533072 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,17984796 0,21521868 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,17984796 0,21510676 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,17984796 0,21499496 ! phospholipid transport GO:0015914 35 25 0,000 0,17984796 0,21488328 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,17984796 0,21477171 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,17984796 0,21466025 ! detection of light stimulus GO:0009583 30 25 0,000 0,17984796 0,21454891 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,17984796 0,21443769 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,17984796 0,21432658 GO:0032943|mononuclear cell proliferation, ! calcium ion transport GO:0006816 167 99 1,000 0,18402514 0,219191 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,18633137 0,22182307 ! translational initiation GO:0006413 43 26 0,000 0,18633137 0,22170831 ! circadian rhythm GO:0007623 42 26 0,000 0,18633137 0,22159367 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,18633137 0,22147915 ! post-embryonic development GO:0009791 42 26 0,000 0,18633137 0,22136475 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,18633137 0,22125047 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,18633137 0,22113631 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,18633137 0,22102226 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,18633137 0,22090833 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,18633137 0,22079452 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,18633137 0,22068083 ! regulation of coagulation GO:0050818 39 26 0,000 0,18633137 0,22056725 ! regulation of translation GO:0006417 151 100 1,000 0,18686774 0,22108838 ! divalent metal ion transport GO:0070838 171 100 1,000 0,18686774 0,22097471 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,19276391 0,2278299 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,19276391 0,22771288 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,19276391 0,22759599 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,19276391 0,22747921 ! membrane docking GO:0022406 39 27 0,000 0,19276391 0,22736256 ! catechol metabolic process GO:0009712 43 27 0,000 0,19276391 0,22724602 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,19276391 0,2271296 ! acute-phase response GO:0006953 42 27 0,000 0,19276391 0,22701331 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,19276391 0,22689713 ! myofibril assembly GO:0030239 36 27 0,000 0,19276391 0,22678107 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,19276391 0,22666513 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,19276391 0,2265493 ! natural killer cell activation GO:0030101 35 27 0,000 0,19276391 0,2264336 ! lipid oxidation GO:0034440 38 27 0,000 0,19276391 0,22631801 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,19276391 0,22620254 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,19276391 0,22608719 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,19276391 0,22597196 GO:0043433|negative regulation of transcription factor activity, ! gene silencing GO:0016458 41 27 0,000 0,19276391 0,22585684 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,19914595 0,23321573 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,19914595 0,23309704 ! phenol metabolic process GO:0018958 44 28 0,000 0,19914595 0,23297848 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,19914595 0,23286003 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,19914595 0,23274171 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,19914595 0,23262351 ! cell junction assembly GO:0034329 56 28 0,000 0,19914595 0,23250542 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,19914595 0,23238746 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,19914595 0,23226962 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,19914595 0,23215189 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,19914595 0,23203429 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,19914595 0,2319168 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,19914595 0,23179944 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,19914595 0,23168219 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,19914595 0,23156506 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,19914595 0,23144805 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,19914595 0,23133115 ! mesoderm formation GO:0001707 46 28 0,000 0,19914595 0,23121438 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,19914595 0,23109772 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,19914595 0,23098118 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,19914595 0,23086476 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,19914595 0,23074846 ! regulation of B cell activation GO:0050864 42 28 0,000 0,19914595 0,23063227 ! regulation of innate immune response GO:0045088 38 29 0,000 0,2054779 0,23784558 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,2054779 0,23772594 ! protein targeting to membrane GO:0006612 53 29 0,000 0,2054779 0,23760642 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,2054779 0,23748702 ! mismatch repair GO:0006298 34 29 0,000 0,2054779 0,23736774 ! muscle cell development GO:0055001 38 29 0,000 0,2054779 0,23724858 ! formation of primary germ layer GO:0001704 48 29 0,000 0,2054779 0,23712954 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,2054779 0,23701062 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,2054779 0,23689182 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,21176015 0,24401219 ! collagen metabolic process GO:0032963 40 30 0,000 0,21176015 0,24389 ! organic anion transport GO:0015711 51 30 0,000 0,21176015 0,24376794 ! cholesterol transport GO:0030301 46 30 0,000 0,21176015 0,24364599 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,21176015 0,24352417 ! spindle organization GO:0007051 37 30 0,000 0,21176015 0,24340247 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,21176015 0,24328089 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,21176015 0,24315943 ! ceramide metabolic process GO:0006672 43 30 0,000 0,21176015 0,24303809 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,21176015 0,24291688 ! adult locomotory behavior GO:0008344 47 30 0,000 0,21176015 0,24279578 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,21176015 0,24267481 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,21176015 0,24255395 ! negative regulation of secretion GO:0051048 49 31 0,000 0,21799308 0,24956898 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,21799308 0,24944482 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,21799308 0,24932078 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,21799308 0,24919686 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,21799308 0,24907306 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,21799308 0,24894939 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,21799308 0,24882585 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,21799308 0,24870242 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,21799308 0,24857912 ! RNA modification GO:0009451 40 31 0,000 0,21799308 0,24845594 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,22417708 0,25537755 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,22417708 0,25525113 ! meiosis I GO:0007127 52 32 0,000 0,22417708 0,25512483 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,22417708 0,25499865 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,22417708 0,2548726 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,22417708 0,25474668 GO:0006639|acylglycerol metabolic process, ! regulation of protein stability GO:0031647 48 32 0,000 0,22417708 0,25462088 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,22417708 0,2544952 ! cytokine production GO:0001816 44 32 0,000 0,22417708 0,25436965 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,22417708 0,25424422 ! vesicle localization GO:0051648 47 32 0,000 0,22417708 0,25411891 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,23031252 0,26094522 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,23031252 0,26081674 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,23031252 0,26068839 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,23031252 0,26056016 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,23031252 0,26043206 ! sister chromatid segregation GO:0000819 46 33 0,000 0,23031252 0,26030408 ! actomyosin structure organization GO:0031032 43 33 0,000 0,23031252 0,26017623 ! cell junction organization GO:0034330 63 33 0,000 0,23031252 0,26004851 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,23031252 0,25992091 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,23031252 0,25979343 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,23031252 0,25966608 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,23031252 0,25953886 ! lipid homeostasis GO:0055088 55 33 0,000 0,23031252 0,25941176 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,23031252 0,25928478 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,23031252 0,25915793 ! cytokinesis GO:0000910 52 33 0,000 0,23031252 0,2590312 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,23031252 0,2589046 ! mRNA catabolic process GO:0006402 48 34 0,000 0,2363998 0,26561775 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,2363998 0,26548806 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,2363998 0,26535849 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,2363998 0,26522904 ! feeding behavior GO:0007631 45 34 0,000 0,2363998 0,26509973 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,2363998 0,26497054 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,2363998 0,26484147 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,2363998 0,26471253 ! female gamete generation GO:0007292 43 34 0,000 0,2363998 0,26458372 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,2363998 0,26445503 ! polyol metabolic process GO:0019751 44 34 0,000 0,2363998 0,26432647 ! aerobic respiration GO:0009060 47 34 0,000 0,2363998 0,26419803 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,2363998 0,26406971 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,24243928 0,27068463 ! Notch signaling pathway GO:0007219 56 35 0,000 0,24243928 0,27055329 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,24243928 0,27042209 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,24243928 0,270291 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,24243928 0,27016005 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,24243928 0,27002922 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,24243928 0,26989852 ! pigment metabolic process GO:0042440 61 35 0,000 0,24243928 0,26976794 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,24243928 0,2696375 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,24243928 0,26950717 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,24843133 0,27603481 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,24843133 0,27590153 ! negative regulation of binding GO:0051100 58 36 0,000 0,24843133 0,27576837 ! organic ether metabolic process GO:0018904 46 36 0,000 0,24843133 0,27563534 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,24843133 0,27550244 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,24843133 0,27536967 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,24843133 0,27523703 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,25437633 0,2816878 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,25437633 0,28155225 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,25437633 0,28141682 ! learning GO:0007612 67 37 0,000 0,25437633 0,28128152 ! ion transmembrane transport GO:0034220 56 37 0,000 0,25437633 0,28114636 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,25437633 0,28101132 ! regulation of protein secretion GO:0050708 51 37 0,000 0,25437633 0,28087641 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,25437633 0,28074163 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,26027465 0,28711352 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,26027465 0,28697588 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,26027465 0,28683837 ! phagocytosis GO:0006909 60 38 0,000 0,26027465 0,286701 ! pigmentation GO:0043473 74 38 0,000 0,26027465 0,28656376 ! maintenance of location in cell GO:0051651 69 38 0,000 0,26027465 0,28642664 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,26612664 0,29272657 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,26612664 0,29258664 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,26612664 0,29244685 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,26612664 0,29230719 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,26612664 0,29216767 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,26612664 0,29202827 ! JNK cascade GO:0007254 54 39 0,000 0,26612664 0,29188901 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,27193266 0,29811493 ! response to calcium ion GO:0051592 58 40 0,000 0,27193266 0,2979729 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,27193266 0,29783101 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,27193266 0,29768925 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,27193266 0,29754763 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epithelial cell differentiation GO:0030855 55 41 0,000 0,27769308 0,30370618 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,27769308 0,30356183 ! endosome transport GO:0016197 71 41 0,000 0,27769308 0,30341762 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,27769308 0,30327355 ! biopolymer methylation GO:0043414 62 41 0,000 0,27769308 0,30312961 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,27769308 0,30298581 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,28340826 0,30907491 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,28340826 0,30892843 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,28340826 0,30878209 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,28340826 0,30863589 ! excretion GO:0007588 63 42 0,000 0,28340826 0,30848982 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,28340826 0,3083439 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,28340826 0,30819811 ! leukocyte migration GO:0050900 60 43 0,000 0,28907854 0,3142158 ! neuromuscular process GO:0050905 79 43 0,000 0,28907854 0,31406738 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,28907854 0,31391909 ! tRNA processing GO:0008033 49 43 0,000 0,28907854 0,31377095 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,28907854 0,31362294 ! vesicle organization GO:0016050 79 43 0,000 0,28907854 0,31347508 ! methylation GO:0032259 64 43 0,000 0,28907854 0,31332735 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,29470427 0,31927453 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,29470427 0,31912421 ! glycolysis GO:0006096 53 44 0,000 0,29470427 0,31897403 ! regulation of ion transport GO:0043269 57 44 0,000 0,29470427 0,318824 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,29470427 0,31867411 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,29470427 0,31852435 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,29470427 0,31837474 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,29470427 0,31822527 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,29470427 0,31807594 ! RNA catabolic process GO:0006401 64 45 0,000 0,30028581 0,3239481 ! positive regulation of defense response GO:0031349 59 45 0,000 0,30028581 0,32379623 ! regulation of translational initiation GO:0006446 64 45 0,000 0,30028581 0,3236445 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,30028581 0,32349291 ! cell recognition GO:0008037 58 45 0,000 0,30028581 0,32334146 ! cell maturation GO:0048469 60 45 0,000 0,30028581 0,32319015 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,30582349 0,32899627 ! cell redox homeostasis GO:0045454 63 46 0,000 0,30582349 0,32884246 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,30582349 0,3286888 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,30582349 0,32853527 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,31131766 0,33428133 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,31131766 0,33412535 ! endocrine system development GO:0035270 83 47 0,000 0,31131766 0,3339695 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,31131766 0,33381381 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,31131766 0,33365825 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,31131766 0,33350285 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,31131766 0,33334759 ! chloride transport GO:0006821 67 48 0,000 0,31676866 0,33902648 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,31676866 0,3388688 ! gastrulation GO:0007369 73 48 0,000 0,31676866 0,33871126 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,31676866 0,33855386 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,31676866 0,33839661 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,31676866 0,33823951 ! nuclear export GO:0051168 69 48 0,000 0,31676866 0,33808256 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,32217682 0,34369512 ! sensory perception of smell GO:0007608 61 49 0,000 0,32217682 0,34353579 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,32217682 0,34337659 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,32217682 0,34321755 ! RNA elongation GO:0006354 62 49 0,000 0,32217682 0,34305865 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,32217682 0,3428999 ! maintenance of location GO:0051235 84 49 0,000 0,32217682 0,3427413 ! regulation of actin filament length GO:0030832 72 50 0,000 0,32754248 0,34828836 ! membrane fusion GO:0006944 80 50 0,000 0,32754248 0,34812741 ! proton transport GO:0015992 75 50 0,000 0,32754248 0,34796661 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,32754248 0,34780596 ! positive regulation of secretion GO:0051047 71 51 0,000 0,33286598 0,35329568 ! hydrogen transport GO:0006818 77 51 0,000 0,33286598 0,35313272 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,33286598 0,35296992 ! adult behavior GO:0030534 80 51 0,000 0,33286598 0,35280726 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,33286598 0,35264475 ! regulation of cellular component size GO:0032535 74 52 0,000 0,33814763 0,3580753 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,33814763 0,35791052 ! establishment of organelle localization GO:0051656 85 52 0,000 0,33814763 0,35774588 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,34338777 0,3631227 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,34338777 0,36295582 ! single fertilization GO:0007338 59 53 0,000 0,34338777 0,3627891 ! amino acid transport GO:0006865 84 54 0,000 0,34858672 0,3681127 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,34858672 0,36794376 ! regulation of mitosis GO:0007088 84 54 0,000 0,34858672 0,36777498 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,34858672 0,36760635 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,34858672 0,36743788 ! exocytosis GO:0006887 74 55 0,000 0,3537448 0,37270409 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,3537448 0,37253344 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,3537448 0,37236295 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,35886233 0,37757702 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,36393963 0,38274401 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,36393963 0,38256908 ! secondary metabolic process GO:0019748 84 57 0,000 0,36393963 0,38239431 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,36897701 0,3875101 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,36897701 0,38733324 ! actin filament organization GO:0007015 95 59 0,000 0,37397478 0,39240054 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,37397478 0,39222161 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,37893325 0,39724088 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,37893325 0,3970599 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,37893325 0,39687909 ! regulation of heart contraction GO:0008016 91 60 0,000 0,37893325 0,39669844 ! fertilization GO:0009566 68 60 0,000 0,37893325 0,39651796 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,38385273 0,40148308 ! meiosis GO:0007126 96 61 0,000 0,38385273 0,40130059 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,38385273 0,40111826 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,38385273 0,4009361 ! extracellular matrix organization GO:0030198 103 61 0,000 0,38385273 0,4007541 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,38385273 0,40057227 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,38873353 0,40548169 ! neurotransmitter transport GO:0006836 81 62 0,000 0,38873353 0,40529788 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,38873353 0,40511424 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,38873353 0,40493076 ! meiotic cell cycle GO:0051321 97 62 0,000 0,38873353 0,40474745 ! organelle localization GO:0051640 96 62 0,000 0,38873353 0,40456431 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,39357594 0,40941866 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,39838026 0,41422903 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,39838026 0,41404185 ! hexose catabolic process GO:0019320 82 64 0,000 0,39838026 0,41385484 ! defense response to bacterium GO:0042742 73 65 0,000 0,4031468 0,41861744 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,4031468 0,41842854 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,4031468 0,4182398 ! activation of immune response GO:0002253 83 65 0,000 0,4031468 0,41805123 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,40787584 0,42276451 ! antigen processing and presentation GO:0019882 96 66 0,000 0,40787584 0,42257407 ! regulation of immune effector process GO:0002697 101 66 0,000 0,40787584 0,42238381 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,41256768 0,42705026 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,41256768 0,42685815 ! acute inflammatory response GO:0002526 92 68 0,000 0,41722262 0,43148023 ! learning or memory GO:0007611 123 68 0,000 0,41722262 0,4312863 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,41722262 0,43109255 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,41722262 0,43089898 ! inorganic anion transport GO:0015698 93 68 0,000 0,41722262 0,43070557 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,42184093 0,43527776 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,42184093 0,43508257 ! humoral immune response GO:0006959 86 70 0,000 0,42642291 0,43961124 ! amine transport GO:0015837 101 70 0,000 0,42642291 0,43941428 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,42642291 0,4392175 ! muscle cell differentiation GO:0042692 104 71 0,000 0,43096883 0,44370112 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,43096883 0,4435026 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,43096883 0,44330425 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,43096883 0,44310608 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,43547898 0,44754319 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,43995365 0,45193988 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,43995365 0,45173812 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,4443931 0,45609287 ! digestion GO:0007586 97 74 0,000 0,4443931 0,45588944 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,4443931 0,45568619 ! blood coagulation GO:0007596 116 75 0,000 0,44879761 0,45999755 GO:0050817|coagulation, ! response to nutrient GO:0007584 104 75 0,000 0,44879761 0,45979265 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,44879761 0,45958794 ! response to unfolded protein GO:0006986 99 76 0,000 0,45316746 0,46385632 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,45750291 0,46808572 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,45750291 0,46787759 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,45750291 0,46766964 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,45750291 0,46746188 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,46180424 0,47164731 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,46180424 0,47143797 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,46180424 0,47122882 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,46607171 0,47537247 ! cellular respiration GO:0045333 107 79 0,000 0,46607171 0,47516176 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,46607171 0,47495123 ! regulation of lyase activity GO:0051339 133 79 0,000 0,46607171 0,47474089 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,46607171 0,47453073 ! chromatin assembly GO:0031497 102 80 0,000 0,47030558 0,47862957 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,47030558 0,47841788 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,47450612 0,48247749 ! hemostasis GO:0007599 125 81 0,000 0,47450612 0,48226429 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,47450612 0,48205127 ! response to protein stimulus GO:0051789 111 81 0,000 0,47450612 0,48183845 ! regulation of neurological system process GO:0031644 122 81 0,000 0,47450612 0,48162581 ! vitamin metabolic process GO:0006766 103 81 0,000 0,47450612 0,48141336 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,47450612 0,48120109 GO:0002696|positive regulation of leukocyte activation, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,48280825 0,48940457 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,48280825 0,48918898 ! regulation of defense response GO:0031347 117 84 0,000 0,48691035 0,49312805 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,48691035 0,49291101 ! sterol metabolic process GO:0016125 120 84 0,000 0,48691035 0,49269415 ! transcription initiation GO:0006352 118 85 0,000 0,49098015 0,49659382 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,4950179 0,50045766 ! nucleosome organization GO:0034728 114 87 0,000 0,49902385 0,50428597 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,49902385 0,5040645 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,49902385 0,50384322 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,50299825 0,50763317 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,50299825 0,50741052 GO:0016054|organic acid catabolic process, ! protein processing GO:0016485 114 88 0,000 0,50299825 0,50718807 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,50694135 0,51094001 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,50694135 0,51071621 ! hormone metabolic process GO:0042445 121 90 0,000 0,51085339 0,51443205 ! ATP metabolic process GO:0046034 137 91 0,000 0,51473461 0,51811362 ! response to virus GO:0009615 122 91 0,000 0,51473461 0,51788697 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,51858526 0,52153306 ! positive regulation of immune response GO:0050778 121 92 0,000 0,51858526 0,52130512 ! DNA recombination GO:0006310 146 92 0,000 0,51858526 0,52107737 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,52240557 0,52468682 ! electron transport chain GO:0022900 123 94 0,000 0,52619579 0,5282629 ! carboxylic acid transport GO:0046942 147 95 0,000 0,52995614 0,5318059 GO:0015849|organic acid transport, ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,53368686 0,53531608 ! protein maturation GO:0051604 129 96 0,000 0,53368686 0,53508273 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,53738818 0,53855897 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,53738818 0,5383244 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,54831806 0,54903419 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,54831806 0,54879527 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,54831806 0,54855656 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,54831806 0,54831806