pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6287-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 8,000 1,968E-10 4,527E-07 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 7,000 1,333E-09 1,532E-06 ! negative regulation of protein kinase activity GO:0006469 99 57 7,000 1,385E-08 1,062E-05 ! negative regulation of kinase activity GO:0033673 100 58 7,000 1,596E-08 9,177E-06 ! negative regulation of peptide secretion GO:0002792 6 5 3,000 1,794E-08 8,252E-06 GO:0046676|negative regulation of insulin secretion, ! spindle assembly GO:0051225 5 5 3,000 1,794E-08 6,877E-06 ! negative regulation of phosphorylation GO:0042326 41 23 5,000 1,877E-08 6,168E-06 ! interphase of mitotic cell cycle GO:0051329 156 86 8,000 2,361E-08 6,787E-06 ! negative regulation of transferase activity GO:0051348 105 61 7,000 2,404E-08 6,144E-06 ! interphase GO:0051325 159 88 8,000 2,895E-08 6,658E-06 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 5,000 3,251E-08 6,798E-06 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of protein export from nucleus GO:0046825 6 6 3,000 5,349E-08 1,025E-05 ! spindle organization GO:0007051 37 30 5,000 1,055E-07 1,867E-05 ! organ growth GO:0035265 11 7 3,000 1,24E-07 2,038E-05 ! regulation of growth hormone secretion GO:0060123 11 7 3,000 1,24E-07 1,902E-05 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 3,000 2,466E-07 3,545E-05 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 3,000 2,466E-07 3,336E-05 ! natural killer cell mediated immunity GO:0002228 13 9 3,000 4,412E-07 5,637E-05 GO:0042267|natural killer cell mediated cytotoxicity, ! cellular response to extracellular stimulus GO:0031668 32 21 4,000 5,053E-07 6,117E-05 ! regulation of B cell proliferation GO:0030888 15 10 3,000 7,308E-07 8,404E-05 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 3,000 7,308E-07 8,004E-05 GO:0010812|negative regulation of cell-substrate adhesion, ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 3,000 7,308E-07 7,64E-05 ! leukocyte mediated cytotoxicity GO:0001909 17 11 3,000 1,141E-06 1,141E-04 ! negative regulation of transport GO:0051051 116 73 6,000 1,648E-06 1,579E-04 ! response to heat GO:0009408 41 30 4,000 3,344E-06 3,076E-04 ! cellular response to starvation GO:0009267 21 14 3,000 3,4E-06 3,007E-04 ! cell killing GO:0001906 20 14 3,000 3,4E-06 2,896E-04 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 4,608E-06 3,785E-04 ! autophagic vacuole formation GO:0000045 8 5 2,000 4,655E-06 3,692E-04 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 2,000 4,655E-06 3,569E-04 ! regulation of protein stability GO:0031647 48 32 4,000 4,666E-06 3,462E-04 ! regulation of intracellular protein transport GO:0033157 59 35 4,000 7,381E-06 5,305E-04 ! positive regulation of hormone secretion GO:0046887 24 17 3,000 7,936E-06 5,531E-04 ! macroautophagy GO:0016236 10 6 2,000 9,256E-06 6,261E-04 ! negative regulation of focal adhesion formation GO:0051895 16 6 2,000 9,256E-06 6,082E-04 ! negative regulation of B cell activation GO:0050869 9 6 2,000 9,256E-06 5,913E-04 ! cellular response to nutrient levels GO:0031669 27 18 3,000 1,014E-05 6,305E-04 ! cell cycle checkpoint GO:0000075 108 64 5,000 1,071E-05 6,484E-04 ! response to starvation GO:0042594 30 19 3,000 1,277E-05 7,53E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 1,45E-05 8,337E-04 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 1,61E-05 9,034E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,61E-05 8,819E-04 ! regulation of focal adhesion formation GO:0051893 17 7 2,000 1,61E-05 8,614E-04 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 4,000 1,851E-05 9,675E-04 ! regulation of insulin secretion GO:0050796 26 21 3,000 1,948E-05 9,955E-04 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 2,366E-05 1,183E-03 GO:0010810|regulation of cell-substrate adhesion, ! induction of positive chemotaxis GO:0050930 14 8 2,000 2,562E-05 1,254E-03 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 2,000 2,562E-05 1,228E-03 ! response to UV GO:0009411 75 46 4,000 2,909E-05 1,365E-03 ! response to temperature stimulus GO:0009266 62 48 4,000 3,588E-05 1,65E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 3,821E-05 1,723E-03 ! regulation of intracellular transport GO:0032386 78 49 4,000 3,971E-05 1,756E-03 ! regulation of peptide secretion GO:0002791 34 25 3,000 4,018E-05 1,744E-03 ! microtubule cytoskeleton organization GO:0000226 120 84 5,000 5,11E-05 2,176E-03 ! positive regulation of MAP kinase activity GO:0043406 121 85 5,000 5,463E-05 2,284E-03 ! negative regulation of transcription regulator activity GO:0090048 47 27 3,000 5,507E-05 2,262E-03 GO:0043433|negative regulation of transcription factor activity, ! cell junction assembly GO:0034329 56 28 3,000 6,386E-05 2,577E-03 ! triglyceride metabolic process GO:0006641 34 28 3,000 6,386E-05 2,532E-03 ! BMP signaling pathway GO:0030509 40 28 3,000 6,386E-05 2,489E-03 ! regulation of B cell activation GO:0050864 42 28 3,000 6,386E-05 2,448E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 7,419E-05 2,797E-03 GO:0050927|positive regulation of positive chemotaxis, ! chondrocyte differentiation GO:0002062 17 11 2,000 7,419E-05 2,752E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 7,419E-05 2,709E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 7,419E-05 2,666E-03 GO:0042130|negative regulation of T cell proliferation, ! DNA damage checkpoint GO:0000077 53 31 3,000 9,636E-05 3,41E-03 ! negative regulation of secretion GO:0051048 49 31 3,000 9,636E-05 3,358E-03 ! cell-cell junction assembly GO:0007043 18 12 2,000 9,836E-05 3,376E-03 ! response to light stimulus GO:0009416 153 96 5,000 1,079E-04 3,65E-03 ! neutral lipid metabolic process GO:0006638 41 32 3,000 1,095E-04 3,649E-03 GO:0006639|acylglycerol metabolic process, ! negative regulation of cell adhesion GO:0007162 67 33 3,000 1,238E-04 4,068E-03 ! cell junction organization GO:0034330 63 33 3,000 1,238E-04 4,011E-03 ! carbohydrate homeostasis GO:0033500 39 33 3,000 1,238E-04 3,955E-03 GO:0042593|glucose homeostasis, ! negative regulation of DNA binding GO:0043392 54 33 3,000 1,238E-04 3,901E-03 ! androgen receptor signaling pathway GO:0030521 54 33 3,000 1,238E-04 3,848E-03 ! negative regulation of cell growth GO:0030308 106 62 4,000 1,242E-04 3,809E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 1,271E-04 3,847E-03 ! positive regulation of bone mineralization GO:0030501 19 13 2,000 1,271E-04 3,797E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 4,000 1,341E-04 3,953E-03 ! DNA integrity checkpoint GO:0031570 57 34 3,000 1,395E-04 4,06E-03 ! glycerol ether metabolic process GO:0006662 44 34 3,000 1,395E-04 4,01E-03 ! negative regulation of cell size GO:0045792 108 64 4,000 1,445E-04 4,104E-03 ! heterophilic cell adhesion GO:0007157 29 14 2,000 1,609E-04 4,512E-03 ! inositol metabolic process GO:0006020 20 14 2,000 1,609E-04 4,458E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 1,609E-04 4,405E-03 GO:0060675|ureteric bud morphogenesis, ! positive regulation of biomineral formation GO:0070169 20 14 2,000 1,609E-04 4,353E-03 ! regulation of hormone secretion GO:0046883 48 36 3,000 1,75E-04 4,68E-03 ! negative regulation of binding GO:0051100 58 36 3,000 1,75E-04 4,627E-03 ! organic ether metabolic process GO:0018904 46 36 3,000 1,75E-04 4,574E-03 ! hormone-mediated signaling GO:0009755 49 36 3,000 1,75E-04 4,523E-03 ! cardiac muscle tissue development GO:0048738 23 15 2,000 1,999E-04 5,11E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,999E-04 5,054E-03 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 1,999E-04 4,999E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,999E-04 4,945E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of phosphorylation GO:0042327 102 70 4,000 2,209E-04 5,406E-03 ! cell growth GO:0016049 61 39 3,000 2,4E-04 5,81E-03 ! endothelial cell migration GO:0043542 22 16 2,000 2,447E-04 5,862E-03 ! G1 phase GO:0051318 27 16 2,000 2,447E-04 5,802E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 2,447E-04 5,742E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 2,522E-04 5,86E-03 GO:0045937|positive regulation of phosphate metabolic process, ! cellular response to hormone stimulus GO:0032870 109 74 4,000 2,868E-04 6,597E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,954E-04 6,727E-03 ! cell-cell junction organization GO:0045216 25 17 2,000 2,954E-04 6,661E-03 ! negative regulation of growth GO:0045926 123 75 4,000 3,054E-04 6,819E-03 ! cellular component disassembly GO:0022411 64 42 3,000 3,207E-04 7,092E-03 ! response to unfolded protein GO:0006986 99 76 4,000 3,248E-04 7,116E-03 ! regulation of protein transport GO:0051223 114 76 4,000 3,248E-04 7,049E-03 GO:0070201|regulation of establishment of protein localization, ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 3,525E-04 7,576E-03 ! regulation of glucose import GO:0046324 21 18 2,000 3,525E-04 7,506E-03 GO:0010827|regulation of glucose transport, ! negative regulation of T cell activation GO:0050868 25 18 2,000 3,525E-04 7,437E-03 ! negative regulation of cell migration GO:0030336 92 44 3,000 3,842E-04 8,034E-03 ! induction of apoptosis by extracellular signals GO:0008624 74 44 3,000 3,842E-04 7,962E-03 ! regulation of mast cell proliferation GO:0070666 64 44 3,000 3,842E-04 7,89E-03 ! positive regulation of ossification GO:0045778 30 19 2,000 4,162E-04 8,47E-03 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 4,162E-04 8,396E-03 ! apoptotic nuclear changes GO:0030262 24 19 2,000 4,162E-04 8,323E-03 ! positive regulation of cell cycle GO:0045787 77 45 3,000 4,192E-04 8,311E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 4,192E-04 8,24E-03 ! response to protein stimulus GO:0051789 111 81 4,000 4,367E-04 8,511E-03 ! positive regulation of locomotion GO:0040017 35 20 2,000 4,868E-04 9,409E-03 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 2,000 4,868E-04 9,33E-03 ! positive regulation of osteoblast differentiation GO:0045669 33 20 2,000 4,868E-04 9,253E-03 ! regulation of leukocyte proliferation GO:0070663 71 47 3,000 4,958E-04 9,346E-03 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of DNA replication GO:0006275 75 48 3,000 5,376E-04 0,01005207 ! regulation of protein localization GO:0032880 132 85 4,000 5,452E-04 0,01011314 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 5,647E-04 0,01039007 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 5,647E-04 0,01030761 ! positive regulation of bone remodeling GO:0046852 33 21 2,000 5,647E-04 0,01022644 GO:0034105|positive regulation of tissue remodeling, ! regulation of chemotaxis GO:0050920 36 21 2,000 5,647E-04 0,01014655 ! autophagy GO:0006914 28 21 2,000 5,647E-04 0,01006789 ! regulation of bone mineralization GO:0030500 29 21 2,000 5,647E-04 9,99E-03 ! cell cycle arrest GO:0007050 150 86 4,000 5,753E-04 0,01010042 ! cartilage development GO:0051216 70 49 3,000 5,818E-04 0,0101378 ! cell adhesion mediated by integrin GO:0033627 8 5 1,000 6,003E-04 0,01038142 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 1,000 6,003E-04 0,01030395 ! lipoprotein particle clearance GO:0034381 9 5 1,000 6,003E-04 0,01022762 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 6,003E-04 0,01015242 ! epithelial cell proliferation GO:0050673 6 5 1,000 6,003E-04 0,01007831 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 6,003E-04 0,01000528 ! sister chromatid cohesion GO:0007062 9 5 1,000 6,003E-04 9,933E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 6,003E-04 9,862E-03 ! lipid modification GO:0030258 73 50 3,000 6,286E-04 0,0102538 ! regulation of multicellular organism growth GO:0040014 65 50 3,000 6,286E-04 0,01018159 ! ureteric bud development GO:0001657 32 22 2,000 6,501E-04 0,01045617 ! regulation of behavior GO:0050795 38 22 2,000 6,501E-04 0,01038356 ! positive regulation of secretion GO:0051047 71 51 3,000 6,78E-04 0,01075432 ! negative regulation of cell motion GO:0051271 104 51 3,000 6,78E-04 0,01068066 ! regulation of biomineral formation GO:0070167 31 23 2,000 7,433E-04 0,01163058 ! regulation of osteoblast differentiation GO:0045667 37 24 2,000 8,447E-04 0,0131269 ! prostate gland development GO:0030850 9 6 1,000 8,958E-04 0,01382852 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 8,958E-04 0,01373633 ! neuron apoptosis GO:0051402 8 6 1,000 8,958E-04 0,01364536 ! wound healing, spreading of epidermal cells GO:0035313 10 6 1,000 8,958E-04 0,01355559 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 8,958E-04 0,01346699 ! midbrain development GO:0030901 6 6 1,000 8,958E-04 0,01337954 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 2,000 9,544E-04 0,01416196 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 9,544E-04 0,01407118 ! DNA damage response, signal transduction GO:0042770 96 56 3,000 9,668E-04 0,01416368 ! multicellular organism reproduction GO:0032504 83 57 3,000 1,034E-03 0,01504512 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 3,000 1,034E-03 0,0149505 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 1,073E-03 0,01542039 ! negative regulation of protein modification process GO:0031400 50 26 2,000 1,073E-03 0,01532461 ! negative regulation of protein kinase cascade GO:0010741 51 26 2,000 1,073E-03 0,01523002 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 1,103E-03 0,01556963 ! activation of MAPK activity GO:0000187 84 59 3,000 1,177E-03 0,01650026 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,2E-03 0,01672629 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,248E-03 0,01728803 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,248E-03 0,01718451 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 1,000 1,248E-03 0,01708222 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 1,000 1,248E-03 0,01698114 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 1,000 1,248E-03 0,01688125 ! phosphoinositide metabolic process GO:0030384 87 60 3,000 1,253E-03 0,01685318 ! regulation of heart contraction GO:0008016 91 60 3,000 1,253E-03 0,01675519 ! urogenital system development GO:0001655 101 61 3,000 1,333E-03 0,01772015 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,336E-03 0,01766318 ! lymphocyte mediated immunity GO:0002449 88 62 3,000 1,416E-03 0,01861317 ! regulation of transcription factor activity GO:0051090 97 63 3,000 1,503E-03 0,01964338 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 1,503E-03 0,0195324 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 3,000 1,594E-03 0,02059302 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,637E-03 0,02103697 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,655E-03 0,02114875 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,655E-03 0,02103191 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,655E-03 0,02091635 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 1,000 1,655E-03 0,02080205 ! intestinal cholesterol absorption GO:0030299 13 8 1,000 1,655E-03 0,020689 ! regulation of gliogenesis GO:0014013 20 8 1,000 1,655E-03 0,02057717 GO:0045685|regulation of glial cell differentiation, ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,655E-03 0,02046654 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,655E-03 0,02035709 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 1,655E-03 0,02024881 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,655E-03 0,02014167 ! maintenance of protein location in cell GO:0032507 60 31 2,000 1,802E-03 0,02181753 ! metanephros development GO:0001656 58 31 2,000 1,802E-03 0,0217033 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,802E-03 0,02159026 GO:0060326|cell chemotaxis, ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 2,117E-03 0,02522962 ! lung alveolus development GO:0048286 17 9 1,000 2,117E-03 0,02509957 ! receptor clustering GO:0043113 15 9 1,000 2,117E-03 0,02497086 ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 2,117E-03 0,02484346 ! localization within membrane GO:0051668 15 9 1,000 2,117E-03 0,02471735 ! nucleus organization GO:0006997 49 33 2,000 2,163E-03 0,02512348 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 3,000 2,218E-03 0,02563797 ! leukocyte mediated immunity GO:0002443 99 71 3,000 2,337E-03 0,02687058 ! polyol metabolic process GO:0019751 44 34 2,000 2,359E-03 0,02698908 ! maintenance of protein location GO:0045185 65 35 2,000 2,565E-03 0,02920611 ! negative regulation of blood pressure GO:0045776 22 10 1,000 2,633E-03 0,02982976 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 2,633E-03 0,02968353 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,633E-03 0,02953874 ! lipid digestion GO:0044241 15 10 1,000 2,633E-03 0,02939535 ! cardiac cell differentiation GO:0035051 16 10 1,000 2,633E-03 0,02925334 ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 2,633E-03 0,0291127 ! cholesterol metabolic process GO:0008203 109 77 3,000 3,139E-03 0,03454441 ! regulation of DNA binding GO:0051101 119 77 3,000 3,139E-03 0,03437991 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 3,201E-03 0,03489656 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 3,201E-03 0,03473195 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 3,201E-03 0,03456889 ! mitotic spindle organization GO:0007052 15 11 1,000 3,201E-03 0,03440735 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 3,201E-03 0,03424732 ! T cell homeostasis GO:0043029 20 11 1,000 3,201E-03 0,03408877 ! regulation of T cell proliferation GO:0042129 58 38 2,000 3,25E-03 0,03444817 ! maintenance of location in cell GO:0051651 69 38 2,000 3,25E-03 0,03429015 ! positive regulation of protein modification process GO:0031401 107 78 3,000 3,289E-03 0,03454093 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 3,501E-03 0,0366009 ! synapse organization GO:0050808 55 39 2,000 3,501E-03 0,03643529 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 3,763E-03 0,03898945 ! intestinal absorption GO:0050892 19 12 1,000 3,822E-03 0,03941957 ! regulation of cell adhesion GO:0030155 159 83 3,000 4,112E-03 0,04221846 ! sterol metabolic process GO:0016125 120 84 3,000 4,291E-03 0,04386844 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 4,323E-03 0,04399811 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 4,476E-03 0,04535639 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 4,494E-03 0,04533194 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 4,494E-03 0,04513399 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 4,494E-03 0,04493775 ! lymphocyte homeostasis GO:0002260 24 13 1,000 4,494E-03 0,04474322 ! leukocyte migration GO:0050900 60 43 2,000 4,621E-03 0,04581345 ! vesicle organization GO:0016050 79 43 2,000 4,621E-03 0,04561683 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 4,621E-03 0,04542188 ! regulation of inflammatory response GO:0050727 60 44 2,000 4,931E-03 0,04826285 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 5,216E-03 0,05083317 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 5,216E-03 0,05061868 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 5,216E-03 0,050406 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 5,216E-03 0,05019509 ! positive regulation of defense response GO:0031349 59 45 2,000 5,253E-03 0,05034597 ! hormone metabolic process GO:0042445 121 90 3,000 5,482E-03 0,0523214 ! regulation of ossification GO:0030278 71 46 2,000 5,588E-03 0,05311079 ! glycerophospholipid metabolic process GO:0006650 130 92 3,000 5,924E-03 0,05606826 ! negative regulation of immune system process GO:0002683 73 47 2,000 5,935E-03 0,05594834 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 5,988E-03 0,05621026 ! lipid phosphorylation GO:0046834 23 15 1,000 5,988E-03 0,05598176 ! isoprenoid biosynthetic process GO:0008299 21 15 1,000 5,988E-03 0,05575511 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 5,988E-03 0,05553029 ! regulation of muscle contraction GO:0006937 69 48 2,000 6,295E-03 0,05814884 ! regulation of binding GO:0051098 151 95 3,000 6,629E-03 0,06098853 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 6,668E-03 0,06109989 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 6,668E-03 0,06085743 ! maintenance of location GO:0051235 84 49 2,000 6,668E-03 0,06061689 ! cellular response to unfolded protein GO:0034620 19 16 1,000 6,808E-03 0,06164755 GO:0030968|endoplasmic reticulum unfolded protein response, ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 1,000 6,808E-03 0,06140579 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 6,808E-03 0,06116593 ! negative regulation of translation GO:0017148 22 16 1,000 6,808E-03 0,06092793 ! activation of phospholipase C activity GO:0007202 87 51 2,000 7,452E-03 0,06643079 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of cell migration GO:0030335 92 51 2,000 7,452E-03 0,0661743 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 7,653E-03 0,06770359 ! zinc ion transport GO:0006829 20 17 1,000 7,676E-03 0,06764629 ! signal complex assembly GO:0007172 29 17 1,000 7,676E-03 0,0673881 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 7,676E-03 0,06713187 ! memory GO:0007613 25 17 1,000 7,676E-03 0,06687759 ! cell-substrate junction assembly GO:0007044 39 17 1,000 7,676E-03 0,06662522 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 7,676E-03 0,06637475 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 7,676E-03 0,06612615 ! synaptogenesis GO:0007416 24 17 1,000 7,676E-03 0,06587941 ! proximal/distal pattern formation GO:0009954 25 17 1,000 7,676E-03 0,06563451 ! positive regulation of phospholipase activity GO:0010518 88 52 2,000 7,863E-03 0,06698398 ! regulation of bone remodeling GO:0046850 90 53 2,000 8,288E-03 0,07034132 ! kidney development GO:0001822 90 53 2,000 8,288E-03 0,07008272 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 8,592E-03 0,07238575 ! pigmentation during development GO:0048066 31 18 1,000 8,592E-03 0,07212157 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 8,592E-03 0,07185931 ! regulation of phospholipase activity GO:0010517 90 54 2,000 8,726E-03 0,07271676 ! DNA catabolic process GO:0006308 67 54 2,000 8,726E-03 0,07245424 ! regulation of tissue remodeling GO:0034103 91 54 2,000 8,726E-03 0,07219362 ! positive regulation of lipase activity GO:0060193 90 54 2,000 8,726E-03 0,07193486 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 9,554E-03 0,07847702 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 9,554E-03 0,07819774 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 9,554E-03 0,07792044 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 9,554E-03 0,07764511 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 9,554E-03 0,07737171 ! digestive system process GO:0022600 30 19 1,000 9,554E-03 0,07710023 ! plasma membrane fusion GO:0045026 23 19 1,000 9,554E-03 0,07683065 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 9,554E-03 0,07656294 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 9,554E-03 0,0762971 ! protein stabilization GO:0050821 26 19 1,000 9,554E-03 0,0760331 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 9,642E-03 0,07647161 ! positive regulation of cell motion GO:0051272 99 56 2,000 9,642E-03 0,07620882 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 0,01012032 0,07971488 ! protein amino acid O-linked glycosylation GO:0006493 29 20 1,000 0,01056116 0,08290331 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 0,01056116 0,08262133 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 0,01056116 0,08234125 ! positive regulation of B cell activation GO:0050871 31 20 1,000 0,01056116 0,08206307 ! phototransduction GO:0007602 25 21 1,000 0,01161342 0,08993559 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01161342 0,08963379 ! cholesterol biosynthetic process GO:0006695 29 21 1,000 0,01161342 0,08933402 ! regulation of vasoconstriction GO:0019229 31 21 1,000 0,01161342 0,08903624 ! platelet activation GO:0030168 28 21 1,000 0,01161342 0,08874043 ! meiosis GO:0007126 96 61 2,000 0,01216979 0,09268383 GO:0051327|M phase of meiotic cell cycle, ! homeostasis of number of cells GO:0048872 84 61 2,000 0,01216979 0,09237795 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01270975 0,09615932 ! leukocyte adhesion GO:0007159 38 22 1,000 0,01270975 0,09584405 ! glutamate signaling pathway GO:0007215 34 22 1,000 0,01270975 0,09553083 ! macromolecular complex disassembly GO:0032984 38 22 1,000 0,01270975 0,09521966 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01270975 0,0949105 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01270975 0,09460335 ! meiotic cell cycle GO:0051321 97 62 2,000 0,01271658 0,09434883 ! regulation of lipase activity GO:0060191 109 63 2,000 0,01327725 0,09819191 ! myelination GO:0042552 35 23 1,000 0,01384941 0,10209503 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01384941 0,10176884 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01384941 0,10144474 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 0,01384941 0,10112269 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01384941 0,10080268 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 1,000 0,01503166 0,10906252 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 1,000 0,01503166 0,10871955 ! fat cell differentiation GO:0045444 37 24 1,000 0,01503166 0,10837874 ! receptor metabolic process GO:0043112 37 24 1,000 0,01503166 0,10804006 ! base-excision repair GO:0006284 31 24 1,000 0,01503166 0,10770348 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 0,01503166 0,107369 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01503166 0,10703659 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,01625577 0,1153959 ! detection of light stimulus GO:0009583 30 25 1,000 0,01625577 0,11504083 ! positive regulation of nuclear division GO:0051785 39 25 1,000 0,01625577 0,11468795 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 0,01625577 0,11433722 ! learning or memory GO:0007611 123 68 2,000 0,01629036 0,11423121 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 2,000 0,01759416 0,12299869 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,01826729 0,12731748 ! steroid biosynthetic process GO:0006694 94 71 2,000 0,01826729 0,12693283 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01882671 0,13042601 ! tube morphogenesis GO:0035239 118 73 2,000 0,0196561 0,13576288 ! mitochondrion organization GO:0007005 104 73 2,000 0,0196561 0,13535641 ! cholesterol homeostasis GO:0042632 46 28 1,000 0,02017213 0,13849523 GO:0055092|sterol homeostasis, ! erythrocyte differentiation GO:0030218 38 28 1,000 0,02017213 0,13808304 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,02017213 0,1376733 ! mesoderm formation GO:0001707 46 28 1,000 0,02017213 0,13726598 ! sterol biosynthetic process GO:0016126 40 28 1,000 0,02017213 0,13686107 ! ensheathment of neurons GO:0007272 43 28 1,000 0,02017213 0,13645853 GO:0008366|axon ensheathment, ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,02155659 0,14539635 ! formation of primary germ layer GO:0001704 48 29 1,000 0,02155659 0,14497121 ! cholesterol transport GO:0030301 46 30 1,000 0,0229794 0,15408928 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 1,000 0,0229794 0,15364134 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,0229794 0,15319601 ! hindbrain development GO:0030902 45 30 1,000 0,0229794 0,15275324 ! glial cell differentiation GO:0010001 55 31 1,000 0,02443989 0,1619935 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 1,000 0,02443989 0,161528 ! odontogenesis GO:0042476 50 31 1,000 0,02443989 0,16106517 ! mesoderm morphogenesis GO:0048332 49 31 1,000 0,02443989 0,16060499 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,0257801 0,16892942 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,02593739 0,16947724 ! meiosis I GO:0007127 52 32 1,000 0,02593739 0,16899713 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,02593739 0,16851974 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02593739 0,16804504 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02747123 0,17748267 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! sister chromatid segregation GO:0000819 46 33 1,000 0,02747123 0,17698552 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02747123 0,17649114 ! lipid homeostasis GO:0055088 55 33 1,000 0,02747123 0,17599952 ! cytokinesis GO:0000910 52 33 1,000 0,02747123 0,17551064 ! regulation of defense response GO:0031347 117 84 2,000 0,02831109 0,18037538 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02904077 0,18451317 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,02904077 0,18400487 ! isoprenoid metabolic process GO:0006720 46 34 1,000 0,02904077 0,18349936 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,02904077 0,18299662 ! transcription initiation GO:0006352 118 85 2,000 0,02918309 0,183391 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,03064536 0,19205537 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,03064536 0,19153348 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,03064536 0,19101442 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! regulation of T cell activation GO:0050863 128 89 2,000 0,03281217 0,20396755 ! learning GO:0007612 67 37 1,000 0,03395714 0,21051598 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 1,000 0,03566309 0,2204976 ! gliogenesis GO:0042063 71 38 1,000 0,03566309 0,21990645 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,03566309 0,21931846 ! mesenchymal cell development GO:0014031 64 38 1,000 0,03566309 0,21873361 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! pigmentation GO:0043473 74 38 1,000 0,03566309 0,21815188 ! cell fate commitment GO:0045165 141 92 2,000 0,03568133 0,21768453 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,03740158 0,22757577 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,03740158 0,22697531 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03857817 0,23349945 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03857817 0,23288659 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03857817 0,23227694 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03857817 0,23167047 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03857817 0,23106717 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03857817 0,23046699 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03857817 0,22986993 ! sleep GO:0030431 11 5 0,000 0,03857817 0,22927595 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03857817 0,22868503 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03857817 0,22809715 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03857817 0,22751229 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03857817 0,22693041 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03857817 0,22635151 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03857817 0,22577555 ! tongue development GO:0043586 6 5 0,000 0,03857817 0,22520252 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03857817 0,22463238 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03857817 0,22406513 ! cobalt ion transport GO:0006824 9 5 0,000 0,03857817 0,22350073 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03857817 0,22293917 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03857817 0,22238043 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03857817 0,22182448 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03857817 0,2212713 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03857817 0,22072087 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03857817 0,22017318 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03857817 0,2196282 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03857817 0,21908591 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03857817 0,21854628 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03857817 0,21800932 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03857817 0,21747498 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03857817 0,21694326 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,03857817 0,21641413 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03857817 0,21588757 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03857817 0,21536357 ! malate metabolic process GO:0006108 7 5 0,000 0,03857817 0,21484211 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03857817 0,21432317 ! behavioral response to pain GO:0048266 7 5 0,000 0,03857817 0,21380673 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03857817 0,21329277 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03857817 0,21278127 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03857817 0,21227223 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03857817 0,21176561 ! mating behavior GO:0007617 6 5 0,000 0,03857817 0,21126141 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03857817 0,2107596 ! rhythmic behavior GO:0007622 12 5 0,000 0,03857817 0,21026017 ! copulation GO:0007620 7 5 0,000 0,03857817 0,2097631 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03857817 0,20926838 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03857817 0,20877598 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03857817 0,2082859 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03857817 0,20779811 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03857817 0,2073126 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03857817 0,20682935 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03857817 0,20634835 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03857817 0,20586959 ! response to protozoan GO:0001562 9 5 0,000 0,03857817 0,20539304 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03857817 0,20491869 ! lymph vessel development GO:0001945 7 5 0,000 0,03857817 0,20444652 ! endochondral ossification GO:0001958 12 5 0,000 0,03857817 0,20397653 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03857817 0,2035087 ! parathyroid gland development GO:0060017 8 5 0,000 0,03857817 0,203043 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03857817 0,20257943 ! anagen GO:0042640 6 5 0,000 0,03857817 0,20211798 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03857817 0,20165862 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03857817 0,20120134 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03857817 0,20074613 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03857817 0,20029298 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03857817 0,19984187 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03857817 0,19939279 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03857817 0,19894572 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03857817 0,19850065 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03857817 0,19805757 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03857817 0,19761646 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,03857817 0,19717731 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03857817 0,19674011 ! ovulation GO:0030728 6 5 0,000 0,03857817 0,19630485 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03857817 0,1958715 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03857817 0,19544007 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,03857817 0,19501053 ! response to pH GO:0009268 9 5 0,000 0,03857817 0,19458288 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03857817 0,19415709 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03857817 0,19373317 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03857817 0,19331109 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03857817 0,19289085 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03857817 0,19247243 ! polyol catabolic process GO:0046174 7 5 0,000 0,03857817 0,19205583 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03857817 0,19164102 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03857817 0,191228 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03857817 0,19081676 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03857817 0,19040728 ! urea metabolic process GO:0019627 6 5 0,000 0,03857817 0,18999955 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03857817 0,18959357 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03857817 0,18918932 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03857817 0,18878679 ! neutrophil activation GO:0042119 5 5 0,000 0,03857817 0,18838597 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03857817 0,18798685 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03857817 0,18758941 ! response to food GO:0032094 5 5 0,000 0,03857817 0,18719365 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03857817 0,18679956 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03857817 0,18640713 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03857817 0,18601633 ! forebrain neuron development GO:0021884 7 5 0,000 0,03857817 0,18562718 ! melanosome organization GO:0032438 7 5 0,000 0,03857817 0,18523965 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03857817 0,18485373 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03857817 0,18446942 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03857817 0,1840867 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03857817 0,18370557 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03857817 0,18332602 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03857817 0,18294802 ! nucleoside transport GO:0015858 6 5 0,000 0,03857817 0,18257159 ! nucleoside salvage GO:0043174 7 5 0,000 0,03857817 0,1821967 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03857817 0,18182334 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03857817 0,18145152 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03857817 0,18108121 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03857817 0,18071241 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03857817 0,1803451 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03857817 0,17997929 ! depyrimidination GO:0045008 8 5 0,000 0,03857817 0,17961496 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03857817 0,1792521 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03857817 0,17889071 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03857817 0,17853077 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03857817 0,17817227 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03857817 0,17781521 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03857817 0,17745958 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03857817 0,17710537 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03857817 0,17675257 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03857817 0,17640118 ! monocyte differentiation GO:0030224 8 5 0,000 0,03857817 0,17605117 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03857817 0,17570256 ! centrosome duplication GO:0051298 5 5 0,000 0,03857817 0,17535532 ! response to UV-C GO:0010225 6 5 0,000 0,03857817 0,17500945 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03857817 0,17466494 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03857817 0,17432179 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03857817 0,17397998 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03857817 0,17363951 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03857817 0,17330037 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03857817 0,17296256 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03857817 0,17262605 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03857817 0,17229086 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03857817 0,17195696 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03857817 0,17162436 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03857817 0,17129303 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03857817 0,17096299 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03857817 0,17063421 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03857817 0,1703067 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03857817 0,16998044 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03857817 0,16965543 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03857817 0,16933166 ! neural tube patterning GO:0021532 6 5 0,000 0,03857817 0,16900913 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03857817 0,16868782 ! histone demethylation GO:0016577 9 5 0,000 0,03857817 0,16836773 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03857817 0,16804885 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03857817 0,16773117 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03857817 0,1674147 ! enteric nervous system development GO:0048484 8 5 0,000 0,03857817 0,16709942 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03857817 0,16678532 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03857817 0,1664724 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03857817 0,16616066 ! transcription termination GO:0006353 8 5 0,000 0,03857817 0,16585008 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03857817 0,16554066 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03857817 0,16523239 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03857817 0,16492526 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03857817 0,16461928 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03857817 0,16431443 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03857817 0,16401071 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03857817 0,1637081 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03857817 0,16340661 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03857817 0,16310623 ! apical protein localization GO:0045176 6 5 0,000 0,03857817 0,16280696 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03857817 0,16250878 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03857817 0,16221168 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03857817 0,16191568 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03857817 0,16162075 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03857817 0,16132689 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03857817 0,1610341 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03857817 0,16074238 ! glial cell migration GO:0008347 10 5 0,000 0,03857817 0,1604517 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03857817 0,16016208 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03857817 0,1598735 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03857817 0,15958596 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03857817 0,15929945 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03857817 0,15901396 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03857817 0,1587295 ! neural plate development GO:0001840 6 5 0,000 0,03857817 0,15844606 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03857817 0,15816362 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03857817 0,15788219 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03857817 0,15760176 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03857817 0,15732233 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03857817 0,15704388 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03857817 0,15676642 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03857817 0,15648993 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03857817 0,15621442 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03857817 0,15593988 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03857817 0,1556663 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03857817 0,15539368 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03857817 0,15512201 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03857817 0,15485129 ! organ regeneration GO:0031100 7 5 0,000 0,03857817 0,15458152 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03857817 0,15431268 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03857817 0,15404478 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03857817 0,1537778 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03857817 0,15351175 GO:0055081|anion homeostasis, ! angiogenesis GO:0001525 149 95 2,000 0,03867576 0,1536343 ! response to calcium ion GO:0051592 58 40 1,000 0,03917202 0,15533731 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03917202 0,15506995 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,03917202 0,15480351 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,03917202 0,15453798 ! positive regulation of protein transport GO:0051222 55 40 1,000 0,03917202 0,15427336 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,03970156 0,1560916 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,03970156 0,15582523 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,04097379 0,16054468 ! endosome transport GO:0016197 71 41 1,000 0,04097379 0,16027164 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,04097379 0,15999953 ! extracellular structure organization GO:0043062 156 99 2,000 0,04286125 0,16708624 ! regulation of translation GO:0006417 151 100 2,000 0,04394176 0,17100855 ! homophilic cell adhesion GO:0007156 149 100 2,000 0,04394176 0,17071968 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,04466901 0,17325248 ! activation of caspase activity GO:0006919 65 43 1,000 0,04466901 0,1729608 ! response to insulin stimulus GO:0032868 63 43 1,000 0,04466901 0,17267011 ! tRNA transcription GO:0009304 11 6 0,000 0,04611463 0,17795916 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04611463 0,17766107 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04611463 0,17736398 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04611463 0,17706788 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04611463 0,17677277 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04611463 0,17647864 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04611463 0,17618548 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04611463 0,1758933 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04611463 0,17560209 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04611463 0,17531183 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04611463 0,17502254 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04611463 0,1747342 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04611463 0,17444681 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04611463 0,17416036 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04611463 0,17387485 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04611463 0,17359028 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04611463 0,17330663 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04611463 0,17302392 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04611463 0,17274212 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04611463 0,17246124 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04611463 0,17218127 ! neuron adhesion GO:0007158 9 6 0,000 0,04611463 0,1719022 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,04611463 0,17162405 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04611463 0,17134679 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04611463 0,17107042 ! signal peptide processing GO:0006465 8 6 0,000 0,04611463 0,17079494 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04611463 0,17052035 ! mRNA stabilization GO:0048255 15 6 0,000 0,04611463 0,17024665 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04611463 0,16997381 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04611463 0,16970186 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04611463 0,16943077 ! opsonization GO:0008228 8 6 0,000 0,04611463 0,16916054 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04611463 0,16889118 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04611463 0,16862267 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04611463 0,16835502 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04611463 0,16808821 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04611463 0,16782225 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04611463 0,16755712 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04611463 0,16729284 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04611463 0,16702939 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04611463 0,16676676 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04611463 0,16650496 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04611463 0,16624398 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04611463 0,16598382 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04611463 0,16572447 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04611463 0,16546593 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04611463 0,16520819 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04611463 0,16495126 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04611463 0,16469512 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04611463 0,16443978 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04611463 0,16418523 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04611463 0,16393147 ! thymic T cell selection GO:0045061 12 6 0,000 0,04611463 0,16367849 ! protein lipoylation GO:0009249 10 6 0,000 0,04611463 0,16342629 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04611463 0,16317486 ! pigment granule organization GO:0048753 11 6 0,000 0,04611463 0,16292421 ! drug transport GO:0015893 6 6 0,000 0,04611463 0,16267433 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04611463 0,16242521 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04611463 0,16217685 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04611463 0,16192925 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04611463 0,16168241 ! histidine metabolic process GO:0006547 6 6 0,000 0,04611463 0,16143632 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04611463 0,16119097 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04611463 0,16094637 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04611463 0,16070252 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04611463 0,16045939 ! adenohypophysis development GO:0021984 10 6 0,000 0,04611463 0,16021701 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04611463 0,15997535 ! hyperosmotic response GO:0006972 8 6 0,000 0,04611463 0,15973443 ! microtubule nucleation GO:0007020 10 6 0,000 0,04611463 0,15949423 ! ER overload response GO:0006983 7 6 0,000 0,04611463 0,15925474 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04611463 0,15901598 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04611463 0,15877793 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04611463 0,1585406 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04611463 0,15830397 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04611463 0,15806805 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,04611463 0,15783283 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04611463 0,15759831 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04611463 0,15736448 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04611463 0,15713135 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04611463 0,15689891 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04611463 0,15666715 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04611463 0,15643608 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04611463 0,15620568 ! organic alcohol transport GO:0015850 9 6 0,000 0,04611463 0,15597597 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04611463 0,15574693 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04611463 0,15551856 ! male sex determination GO:0030238 9 6 0,000 0,04611463 0,15529086 ! carnitine transport GO:0015879 8 6 0,000 0,04611463 0,15506383 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04611463 0,15483746 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04611463 0,15461175 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04611463 0,1543867 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04611463 0,1541623 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04611463 0,15393855 ! parturition GO:0007567 12 6 0,000 0,04611463 0,15371545 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04611463 0,153493 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04611463 0,15327118 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04611463 0,15305001 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04611463 0,15282948 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04611463 0,15260958 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04611463 0,15239032 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04611463 0,15217168 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04611463 0,15195367 ! macrophage differentiation GO:0030225 10 6 0,000 0,04611463 0,15173628 ! astrocyte development GO:0014002 14 6 0,000 0,04611463 0,15151951 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04611463 0,15130337 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04611463 0,15108783 ! interaction with symbiont GO:0051702 8 6 0,000 0,04611463 0,15087292 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04611463 0,15065861 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04611463 0,15044491 ! eating behavior GO:0042755 6 6 0,000 0,04611463 0,15023181 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04611463 0,15001932 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04611463 0,14980743 ! response to copper ion GO:0046688 9 6 0,000 0,04611463 0,14959614 ! DNA topological change GO:0006265 8 6 0,000 0,04611463 0,14938544 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04611463 0,14917533 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04611463 0,14896581 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04611463 0,14875689 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04611463 0,14854854 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04611463 0,14834078 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04611463 0,1481336 ! gas homeostasis GO:0033483 11 6 0,000 0,04611463 0,147927 ! hair follicle maturation GO:0048820 7 6 0,000 0,04611463 0,14772097 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04611463 0,14751552 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04611463 0,14731064 ! Schwann cell development GO:0014044 14 6 0,000 0,04611463 0,14710632 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04611463 0,14690258 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04611463 0,14669939 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04611463 0,14649677 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04611463 0,1462947 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04611463 0,1460932 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04611463 0,14589224 ! histone ubiquitination GO:0016574 7 6 0,000 0,04611463 0,14569184 ! regulation of meiosis GO:0040020 10 6 0,000 0,04611463 0,14549199 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04611463 0,14529268 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04611463 0,14509393 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04611463 0,14489571 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04611463 0,14469804 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04611463 0,1445009 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04611463 0,1443043 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04611463 0,14410823 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04611463 0,1439127 ! receptor internalization GO:0031623 9 6 0,000 0,04611463 0,1437177 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04611463 0,14352322 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04611463 0,14332927 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04611463 0,14313584 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04611463 0,14294294 ! protein deubiquitination GO:0016579 8 6 0,000 0,04611463 0,14275055 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04611463 0,14255868 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04611463 0,14236733 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04611463 0,14217649 ! axonal fasciculation GO:0007413 9 6 0,000 0,04611463 0,14198616 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04611463 0,14179634 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04611463 0,14160702 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04611463 0,14141821 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04611463 0,14122991 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04611463 0,1410421 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04611463 0,14085479 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04611463 0,14066798 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04611463 0,14048167 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04611463 0,14029585 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04611463 0,14011052 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04611463 0,13992567 ! adult feeding behavior GO:0008343 6 6 0,000 0,04611463 0,13974132 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04611463 0,13955745 ! blastocyst growth GO:0001832 15 6 0,000 0,04611463 0,13937406 ! pigment granule transport GO:0051904 12 6 0,000 0,04611463 0,13919115 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04611463 0,13900873 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04611463 0,13882678 ! catecholamine transport GO:0051937 7 6 0,000 0,04611463 0,13864531 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04611463 0,13846431 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04611463 0,13828378 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04611463 0,13810372 ! protein prenylation GO:0018342 10 6 0,000 0,04611463 0,13792414 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04611463 0,13774501 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04611463 0,13756636 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04611463 0,13738816 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04611463 0,13721043 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04611463 0,13703315 ! regulation of action potential GO:0001508 71 44 1,000 0,04656128 0,13818188 ! ribonucleoprotein complex assembly GO:0022618 70 44 1,000 0,04656128 0,13800381 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,04656128 0,1378262 ! regulation of translational initiation GO:0006446 64 45 1,000 0,04848258 0,14332895 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05359245 0,15823188 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05359245 0,15802902 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05359245 0,15782668 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05359245 0,15762485 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05359245 0,15742354 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05359245 0,15722275 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05359245 0,15702246 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05359245 0,15682269 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05359245 0,15662342 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05359245 0,15642466 ! reproductive behavior GO:0019098 12 7 0,000 0,05359245 0,15622641 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05359245 0,15602865 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05359245 0,1558314 ! oligopeptide transport GO:0006857 11 7 0,000 0,05359245 0,15563464 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05359245 0,15543838 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05359245 0,15524261 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05359245 0,15504734 ! RNA methylation GO:0001510 11 7 0,000 0,05359245 0,15485256 ! pericardium development GO:0060039 8 7 0,000 0,05359245 0,15465826 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05359245 0,15446445 ! fibril organization GO:0043206 13 7 0,000 0,05359245 0,15427113 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,05359245 0,15407829 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05359245 0,15388594 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,05359245 0,15369406 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05359245 0,15350266 ! lipoprotein transport GO:0042953 9 7 0,000 0,05359245 0,15331173 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05359245 0,15312129 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05359245 0,15293131 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05359245 0,1527418 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05359245 0,15255277 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05359245 0,1523642 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05359245 0,15217609 ! chemosensory behavior GO:0007635 9 7 0,000 0,05359245 0,15198845 ! microtubule bundle formation GO:0001578 8 7 0,000 0,05359245 0,15180127 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05359245 0,15161456 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05359245 0,1514283 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05359245 0,1512425 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05359245 0,15105715 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05359245 0,15087226 ! reflex GO:0060004 12 7 0,000 0,05359245 0,15068782 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05359245 0,15050383 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05359245 0,15032029 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05359245 0,15013719 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05359245 0,14995454 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05359245 0,14977234 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05359245 0,14959058 ! spinal cord patterning GO:0021511 7 7 0,000 0,05359245 0,14940925 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05359245 0,14922837 ! adrenal gland development GO:0030325 17 7 0,000 0,05359245 0,14904793 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05359245 0,14886792 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05359245 0,14868834 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05359245 0,1485092 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05359245 0,14833049 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05359245 0,1481522 ! endosome organization GO:0007032 10 7 0,000 0,05359245 0,14797435 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05359245 0,14779692 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05359245 0,14761992 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05359245 0,14744334 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,05359245 0,14726719 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05359245 0,14709145 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05359245 0,14691613 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05359245 0,14674123 ! galactose metabolic process GO:0006012 10 7 0,000 0,05359245 0,14656675 ! vesicle fusion GO:0006906 15 7 0,000 0,05359245 0,14639268 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05359245 0,14621902 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05359245 0,14604578 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05359245 0,14587294 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05359245 0,14570051 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05359245 0,14552849 ! retinol metabolic process GO:0042572 9 7 0,000 0,05359245 0,14535688 ! behavioral fear response GO:0001662 13 7 0,000 0,05359245 0,14518567 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,05359245 0,14501486 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05359245 0,14484446 ! rRNA modification GO:0000154 12 7 0,000 0,05359245 0,14467445 ! protein heterooligomerization GO:0051291 10 7 0,000 0,05359245 0,14450485 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05359245 0,14433564 ! response to UV-B GO:0010224 11 7 0,000 0,05359245 0,14416682 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,05359245 0,1439984 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05359245 0,14383038 ! intermediate filament organization GO:0045109 11 7 0,000 0,05359245 0,14366274 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05359245 0,1434955 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05359245 0,14332864 ! fibrinolysis GO:0042730 9 7 0,000 0,05359245 0,14316218 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05359245 0,1429961 ! B cell lineage commitment GO:0002326 17 7 0,000 0,05359245 0,1428304 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05359245 0,14266509 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05359245 0,14250016 ! response to tropane GO:0014073 13 7 0,000 0,05359245 0,14233561 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05359245 0,14217144 ! melanosome localization GO:0032400 10 7 0,000 0,05359245 0,14200764 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05359245 0,14184423 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05359245 0,14168119 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05359245 0,14151852 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05359245 0,14135623 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05359245 0,14119431 ! mast cell activation GO:0045576 9 7 0,000 0,05359245 0,14103276 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05359245 0,14087158 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05359245 0,14071077 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05359245 0,14055032 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05359245 0,14039024 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05359245 0,14023053 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05359245 0,14007118 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05359245 0,13991218 ! T cell lineage commitment GO:0002360 12 7 0,000 0,05359245 0,13975355 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05359245 0,13959528 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05359245 0,13943737 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05359245 0,13927981 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05359245 0,13912261 ! response to tumor cell GO:0002347 12 7 0,000 0,05359245 0,13896577 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05359245 0,13880927 ! neuroblast proliferation GO:0007405 13 7 0,000 0,05359245 0,13865313 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05359245 0,13849734 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05359245 0,1383419 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,05359245 0,13818681 ! diuresis GO:0030146 12 7 0,000 0,05359245 0,13803207 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05359245 0,13787767 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05359245 0,13772361 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05359245 0,1375699 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05359245 0,13741654 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05359245 0,13726351 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05359245 0,13711083 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05359245 0,13695848 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05359245 0,13680648 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05359245 0,13665481 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05359245 0,13650347 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,05359245 0,13635247 ! lymph node development GO:0048535 9 7 0,000 0,05359245 0,13620181 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05359245 0,13605147 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05359245 0,13590147 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05359245 0,1357518 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05359245 0,13560246 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05359245 0,13545344 ! ATP catabolic process GO:0006200 10 7 0,000 0,05359245 0,13530476 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05359245 0,1351564 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,05359245 0,13500836 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05359245 0,13486065 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05359245 0,13471326 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05359245 0,13456619 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05359245 0,13441945 ! muscle adaptation GO:0043500 12 7 0,000 0,05359245 0,13427302 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05359245 0,13412691 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05359245 0,13398112 ! retina homeostasis GO:0001895 9 7 0,000 0,05359245 0,13383565 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05359245 0,13369049 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05359245 0,13354565 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05359245 0,13340112 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05359245 0,1332569 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05359245 0,133113 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,05441495 0,13501013 GO:0010952|positive regulation of peptidase activity, ! gastrulation GO:0007369 73 48 1,000 0,05441495 0,13486464 ! heart morphogenesis GO:0003007 65 48 1,000 0,05441495 0,13471947 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,05441495 0,13457461 ! membrane fusion GO:0006944 80 50 1,000 0,0585048 0,14453388 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,0605886 0,14952122 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,0605886 0,14936096 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06101207 0,15024385 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06101207 0,15008316 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,06101207 0,14992282 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06101207 0,14976281 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06101207 0,14960315 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06101207 0,14944383 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06101207 0,14928485 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06101207 0,1491262 ! phosphate transport GO:0006817 10 8 0,000 0,06101207 0,1489679 ! N-glycan processing GO:0006491 12 8 0,000 0,06101207 0,14880992 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,06101207 0,14865229 ! UTP metabolic process GO:0046051 8 8 0,000 0,06101207 0,14849498 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06101207 0,14833801 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,06101207 0,14818137 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06101207 0,14802506 ! succinate metabolic process GO:0006105 14 8 0,000 0,06101207 0,14786908 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,06101207 0,14771343 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,06101207 0,1475581 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06101207 0,14740311 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,06101207 0,14724843 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,06101207 0,14709409 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,06101207 0,14694006 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06101207 0,14678636 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,06101207 0,14663298 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06101207 0,14647991 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06101207 0,14632717 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06101207 0,14617475 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06101207 0,14602264 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06101207 0,14587085 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06101207 0,14571937 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06101207 0,14556821 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06101207 0,14541736 ! astrocyte differentiation GO:0048708 16 8 0,000 0,06101207 0,14526683 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06101207 0,14511661 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,06101207 0,14496669 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06101207 0,14481709 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06101207 0,14466779 ! melanin metabolic process GO:0006582 12 8 0,000 0,06101207 0,1445188 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06101207 0,14437012 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,06101207 0,14422174 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,06101207 0,14407367 ! macrophage activation GO:0042116 12 8 0,000 0,06101207 0,1439259 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06101207 0,14377844 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,06101207 0,14363128 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,06101207 0,14348441 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06101207 0,14333785 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,06101207 0,14319159 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,06101207 0,14304562 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06101207 0,14289996 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06101207 0,14275459 ! ruffle organization GO:0031529 11 8 0,000 0,06101207 0,14260951 ! osteoblast development GO:0002076 13 8 0,000 0,06101207 0,14246473 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06101207 0,14232024 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06101207 0,14217605 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06101207 0,14203214 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06101207 0,14188853 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06101207 0,14174521 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,06101207 0,14160218 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06101207 0,14145943 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06101207 0,14131698 ! brain morphogenesis GO:0048854 20 8 0,000 0,06101207 0,14117481 ! oligodendrocyte development GO:0014003 8 8 0,000 0,06101207 0,14103292 ! segment specification GO:0007379 10 8 0,000 0,06101207 0,14089132 ! cellular extravasation GO:0045123 11 8 0,000 0,06101207 0,14075001 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06101207 0,14060898 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06101207 0,14046823 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06101207 0,14032776 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06101207 0,14018757 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06101207 0,14004766 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06101207 0,13990803 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,06101207 0,13976868 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06101207 0,13962961 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06101207 0,13949081 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,06101207 0,13935229 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06101207 0,13921404 ! icosanoid secretion GO:0032309 12 8 0,000 0,06101207 0,13907607 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,06101207 0,13893837 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06101207 0,13880095 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06101207 0,13866379 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06101207 0,13852691 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06101207 0,13839029 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06101207 0,13825395 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06101207 0,13811787 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06101207 0,13798206 ! sterol catabolic process GO:0016127 9 8 0,000 0,06101207 0,13784652 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06101207 0,13771124 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06101207 0,13757623 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06101207 0,13744149 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06101207 0,137307 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06101207 0,13717278 ! prophase GO:0051324 11 8 0,000 0,06101207 0,13703883 ! S phase GO:0051320 8 8 0,000 0,06101207 0,13690513 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06101207 0,13677169 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06101207 0,13663852 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06101207 0,1365056 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06101207 0,13637294 ! hormone catabolic process GO:0042447 13 8 0,000 0,06101207 0,13624054 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06101207 0,1361084 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,06101207 0,13597651 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06101207 0,13584488 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06101207 0,1357135 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06101207 0,13558237 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,06101207 0,1354515 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06101207 0,13532088 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06101207 0,13519052 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06101207 0,1350604 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06101207 0,13493054 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,06101207 0,13480092 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06101207 0,13467155 ! regulation of embryonic development GO:0045995 16 8 0,000 0,06101207 0,13454243 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06101207 0,13441356 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06101207 0,13428494 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,06101207 0,13415656 ! transition metal ion transport GO:0000041 74 52 1,000 0,06269761 0,13773113 ! aging GO:0007568 79 52 1,000 0,06269761 0,13759971 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,06269761 0,13746854 ! establishment of organelle localization GO:0051656 85 52 1,000 0,06269761 0,13733762 ! single fertilization GO:0007338 59 53 1,000 0,06483132 0,14187633 ! regulation of mitosis GO:0007088 84 54 1,000 0,06698921 0,1464593 GO:0051783|regulation of nuclear division, ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,06698921 0,14632022 ! detection of external stimulus GO:0009581 66 54 1,000 0,06698921 0,14618139 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06837394 0,14906167 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06837394 0,14892051 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06837394 0,14877962 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06837394 0,148639 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06837394 0,14849864 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06837394 0,14835855 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06837394 0,14821872 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06837394 0,14807915 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06837394 0,14793985 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06837394 0,14780081 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06837394 0,14766203 ! GTP metabolic process GO:0046039 9 9 0,000 0,06837394 0,14752351 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06837394 0,14738525 ! social behavior GO:0035176 14 9 0,000 0,06837394 0,14724725 ! artery development GO:0060840 19 9 0,000 0,06837394 0,14710951 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06837394 0,14697202 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06837394 0,14683479 ! response to pain GO:0048265 16 9 0,000 0,06837394 0,14669782 ! protein complex disassembly GO:0043241 17 9 0,000 0,06837394 0,1465611 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06837394 0,14642464 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06837394 0,14628843 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06837394 0,14615247 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06837394 0,14601677 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06837394 0,14588132 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06837394 0,14574612 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06837394 0,14561117 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06837394 0,14547647 ! protein targeting to ER GO:0045047 19 9 0,000 0,06837394 0,14534202 ! T cell selection GO:0045058 18 9 0,000 0,06837394 0,14520781 ! endoderm development GO:0007492 12 9 0,000 0,06837394 0,14507386 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06837394 0,14494015 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06837394 0,14480669 ! arginine catabolic process GO:0006527 10 9 0,000 0,06837394 0,14467347 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06837394 0,1445405 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06837394 0,14440777 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06837394 0,14427529 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06837394 0,14414305 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06837394 0,14401105 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06837394 0,14387929 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06837394 0,14374777 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06837394 0,1436165 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06837394 0,14348546 ! mannose metabolic process GO:0006013 9 9 0,000 0,06837394 0,14335466 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06837394 0,1432241 ! epithelial cell development GO:0002064 10 9 0,000 0,06837394 0,14309378 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06837394 0,14296369 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06837394 0,14283384 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06837394 0,14270423 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06837394 0,14257485 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06837394 0,14244571 ! motor axon guidance GO:0008045 14 9 0,000 0,06837394 0,1423168 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06837394 0,14218812 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06837394 0,14205968 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06837394 0,14193146 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06837394 0,14180348 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06837394 0,14167573 ! DNA ligation GO:0006266 14 9 0,000 0,06837394 0,14154821 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06837394 0,14142092 ! response to amine stimulus GO:0014075 13 9 0,000 0,06837394 0,14129386 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06837394 0,14116702 ! erythrocyte development GO:0048821 11 9 0,000 0,06837394 0,14104041 ! renal water homeostasis GO:0003091 14 9 0,000 0,06837394 0,14091403 ! postreplication repair GO:0006301 11 9 0,000 0,06837394 0,14078788 ! mRNA cleavage GO:0006379 13 9 0,000 0,06837394 0,14066195 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06837394 0,14053625 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06837394 0,14041077 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06837394 0,14028551 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06837394 0,14016048 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06837394 0,14003567 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06837394 0,13991109 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06837394 0,13978672 ! acid secretion GO:0046717 14 9 0,000 0,06837394 0,13966258 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06837394 0,13953865 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06837394 0,13941495 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06837394 0,13929146 ! purine base metabolic process GO:0006144 18 9 0,000 0,06837394 0,1391682 ! oocyte differentiation GO:0009994 12 9 0,000 0,06837394 0,13904515 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,06837394 0,13892232 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06837394 0,1387997 ! spleen development GO:0048536 15 9 0,000 0,06837394 0,1386773 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06837394 0,13855512 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06837394 0,13843315 ! detection of calcium ion GO:0005513 13 9 0,000 0,06837394 0,1383114 ! blastocyst formation GO:0001825 12 9 0,000 0,06837394 0,13818986 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06837394 0,13806854 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06837394 0,13794742 ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06837394 0,13782652 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06837394 0,13770583 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06837394 0,13758536 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06837394 0,13746509 ! prepulse inhibition GO:0060134 14 9 0,000 0,06837394 0,13734503 ! embryonic placenta development GO:0001892 12 9 0,000 0,06837394 0,13722519 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06837394 0,13710555 ! insulin secretion GO:0030073 17 9 0,000 0,06837394 0,13698612 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06837394 0,13686689 ! response to nicotine GO:0035094 16 9 0,000 0,06837394 0,13674788 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06837394 0,13662907 ! nucleus localization GO:0051647 15 9 0,000 0,06837394 0,13651047 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06837394 0,13639207 ! mesoderm development GO:0007498 76 55 1,000 0,06917079 0,13786207 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,07137556 0,14213315 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07567851 0,15057143 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07567851 0,15044129 ! neuron fate specification GO:0048665 11 10 0,000 0,07567851 0,15031138 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07567851 0,15018169 ! thyroid gland development GO:0030878 19 10 0,000 0,07567851 0,15005222 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07567851 0,14992298 ! synapsis GO:0007129 13 10 0,000 0,07567851 0,14979395 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07567851 0,14966516 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07567851 0,14953658 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,07567851 0,14940822 ! sulfate transport GO:0008272 12 10 0,000 0,07567851 0,14928008 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07567851 0,14915216 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07567851 0,14902447 ! androgen metabolic process GO:0008209 13 10 0,000 0,07567851 0,14889699 ! phospholipid efflux GO:0033700 16 10 0,000 0,07567851 0,14876972 ! hippocampus development GO:0021766 19 10 0,000 0,07567851 0,14864268 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07567851 0,14851585 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07567851 0,14838924 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07567851 0,14826284 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07567851 0,14813666 ! pathogenesis GO:0009405 13 10 0,000 0,07567851 0,14801069 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07567851 0,14788494 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07567851 0,1477594 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07567851 0,14763408 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,07567851 0,14750896 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,07567851 0,14738406 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07567851 0,14725937 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07567851 0,14713489 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07567851 0,14701062 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07567851 0,14688656 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07567851 0,14676271 ! response to X-ray GO:0010165 16 10 0,000 0,07567851 0,14663907 ! B cell proliferation GO:0042100 14 10 0,000 0,07567851 0,14651564 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07567851 0,14639241 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07567851 0,14626939 ! forebrain cell migration GO:0021885 17 10 0,000 0,07567851 0,14614658 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,07567851 0,14602397 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07567851 0,14590157 ! UV protection GO:0009650 14 10 0,000 0,07567851 0,14577938 ! entry into host cell GO:0030260 20 10 0,000 0,07567851 0,14565739 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,07567851 0,1455356 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07567851 0,14541401 ! negative regulation of ossification GO:0030279 19 10 0,000 0,07567851 0,14529263 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07567851 0,14517146 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,07567851 0,14505048 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07567851 0,1449297 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,07567851 0,14480913 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07567851 0,14468876 ! regulation of organ growth GO:0046620 11 10 0,000 0,07567851 0,14456858 ! response to dsRNA GO:0043331 18 10 0,000 0,07567851 0,14444861 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07567851 0,14432884 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07567851 0,14420926 ! embryonic axis specification GO:0000578 12 10 0,000 0,07567851 0,14408988 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07567851 0,1439707 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07567851 0,14385172 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07567851 0,14373293 ! cranial nerve development GO:0021545 12 10 0,000 0,07567851 0,14361434 ! fucose catabolic process GO:0019317 16 10 0,000 0,07567851 0,14349594 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,07567851 0,14337774 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07567851 0,14325973 ! protein sumoylation GO:0016925 12 10 0,000 0,07567851 0,14314192 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07567851 0,1430243 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07567851 0,14290688 ! zymogen activation GO:0031638 14 10 0,000 0,07567851 0,14278964 ! salivary gland development GO:0007431 22 10 0,000 0,07567851 0,1426726 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07567851 0,14255575 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07567851 0,1424391 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07567851 0,14232263 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07567851 0,14220635 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,07567851 0,14209027 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,07567851 0,14197437 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07567851 0,14185866 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07567851 0,14174314 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07567851 0,14162781 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,07567851 0,14151266 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07567851 0,14139771 ! detection of bacterium GO:0016045 10 10 0,000 0,07567851 0,14128293 ! embryonic gut development GO:0048566 11 10 0,000 0,07567851 0,14116835 ! activation of innate immune response GO:0002218 10 10 0,000 0,07567851 0,14105395 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07567851 0,14093974 ! developmental induction GO:0031128 13 10 0,000 0,07567851 0,14082571 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07567851 0,14071186 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07567851 0,1405982 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07567851 0,14048473 ! lung development GO:0030324 94 59 1,000 0,0781241 0,14490761 ! actin filament organization GO:0007015 95 59 1,000 0,0781241 0,14479084 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,0781241 0,14467426 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,08041677 0,14880013 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,08041677 0,14868052 GO:0035113|embryonic appendage morphogenesis, ! fertilization GO:0009566 68 60 1,000 0,08041677 0,1485611 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,08273022 0,15271229 ! lipoprotein metabolic process GO:0042157 89 61 1,000 0,08273022 0,15258983 ! negative regulation of ligase activity GO:0051352 91 61 1,000 0,08273022 0,15246756 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! rRNA transcription GO:0009303 17 11 0,000 0,08292622 0,15270642 ! respiratory burst GO:0045730 14 11 0,000 0,08292622 0,15258425 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,08292622 0,15246228 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,08292622 0,15234051 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,08292622 0,15221893 ! virus-host interaction GO:0019048 17 11 0,000 0,08292622 0,15209754 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,08292622 0,15197635 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,08292622 0,15185535 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,08292622 0,15173454 ! RNA polyadenylation GO:0043631 19 11 0,000 0,08292622 0,15161392 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,08292622 0,1514935 ! mating GO:0007618 14 11 0,000 0,08292622 0,15137327 ! T cell proliferation GO:0042098 20 11 0,000 0,08292622 0,15125322 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,08292622 0,15113337 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,08292622 0,15101371 ! bone resorption GO:0045453 16 11 0,000 0,08292622 0,15089424 ! regulated secretory pathway GO:0045055 14 11 0,000 0,08292622 0,15077495 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,08292622 0,15065586 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,08292622 0,15053695 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,08292622 0,15041823 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,08292622 0,1502997 ! syncytium formation GO:0006949 15 11 0,000 0,08292622 0,15018135 ! plasma membrane organization GO:0007009 18 11 0,000 0,08292622 0,15006319 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,08292622 0,14994522 ! focal adhesion formation GO:0048041 24 11 0,000 0,08292622 0,14982743 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,08292622 0,14970982 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,08292622 0,1495924 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,08292622 0,14947517 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,08292622 0,14935812 ! adult heart development GO:0007512 11 11 0,000 0,08292622 0,14924125 ! temperature homeostasis GO:0001659 16 11 0,000 0,08292622 0,14912456 ! L-glutamate transport GO:0015813 16 11 0,000 0,08292622 0,14900806 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,08292622 0,14889174 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,08292622 0,1487756 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,08292622 0,14865964 ! stem cell development GO:0048864 29 11 0,000 0,08292622 0,14854386 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,08292622 0,14842826 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,08292622 0,14831284 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,08292622 0,1481976 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,08292622 0,14808254 ! vasoconstriction GO:0042310 15 11 0,000 0,08292622 0,14796766 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,08292622 0,14785296 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,08292622 0,14773843 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,08292622 0,14762408 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,08292622 0,14750991 ! ribosome assembly GO:0042255 13 11 0,000 0,08292622 0,14739592 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,08292622 0,1472821 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,08292622 0,14716845 ! chromatin silencing GO:0006342 19 11 0,000 0,08292622 0,14705499 ! nucleosome positioning GO:0016584 13 11 0,000 0,08292622 0,14694169 ! regulation of isotype switching GO:0045191 19 11 0,000 0,08292622 0,14682857 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,08292622 0,14671563 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,08292622 0,14660286 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,08292622 0,14649026 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,08292622 0,14637783 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,08292622 0,14626558 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,08292622 0,1461535 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,08292622 0,14604159 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,08292622 0,14592985 ! male genitalia development GO:0030539 13 11 0,000 0,08292622 0,14581828 ! cholesterol efflux GO:0033344 19 11 0,000 0,08292622 0,14570689 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,08292622 0,14559566 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,08292622 0,1454846 ! germ cell migration GO:0008354 18 11 0,000 0,08292622 0,14537372 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,08292622 0,145263 ! defense response to fungus GO:0050832 12 11 0,000 0,08292622 0,14515245 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,08292622 0,14504207 ! lysogeny GO:0030069 18 11 0,000 0,08292622 0,14493185 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,08292622 0,1448218 ! acrosome reaction GO:0007340 13 11 0,000 0,08292622 0,14471192 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,08292622 0,14460221 ! respiratory tube development GO:0030323 99 62 1,000 0,08506401 0,1482176 ! organelle localization GO:0051640 96 62 1,000 0,08506401 0,1481054 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,08741768 0,15208824 ! appendage morphogenesis GO:0035107 93 64 1,000 0,08979077 0,15609884 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 1,000 0,08979077 0,15598094 ! lactation GO:0007595 20 12 0,000 0,09011752 0,15643041 ! reproductive cellular process GO:0048610 14 12 0,000 0,09011752 0,15631244 ! tRNA modification GO:0006400 14 12 0,000 0,09011752 0,15619464 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,09011752 0,15607703 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,09011752 0,15595959 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,09011752 0,15584233 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,09011752 0,15572524 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,09011752 0,15560833 ! non-recombinational repair GO:0000726 19 12 0,000 0,09011752 0,15549159 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,09011752 0,15537503 ! peroxisomal transport GO:0043574 21 12 0,000 0,09011752 0,15525865 ! cartilage condensation GO:0001502 18 12 0,000 0,09011752 0,15514244 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,09011752 0,1550264 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,09011752 0,15491053 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,09011752 0,15479484 ! heart looping GO:0001947 15 12 0,000 0,09011752 0,15467932 ! palate development GO:0060021 15 12 0,000 0,09011752 0,15456398 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,09011752 0,1544488 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,09011752 0,1543338 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,09011752 0,15421897 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,09011752 0,15410431 ! arginine metabolic process GO:0006525 13 12 0,000 0,09011752 0,15398982 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,09011752 0,1538755 ! methionine metabolic process GO:0006555 13 12 0,000 0,09011752 0,15376135 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,09011752 0,15364736 ! Golgi organization GO:0007030 18 12 0,000 0,09011752 0,15353355 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,09011752 0,15341991 ! monoamine transport GO:0015844 13 12 0,000 0,09011752 0,15330643 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,09011752 0,15319312 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,09011752 0,15307998 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,09011752 0,15296701 ! L-amino acid transport GO:0015807 20 12 0,000 0,09011752 0,1528542 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,09011752 0,15274156 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,09011752 0,15262908 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,09011752 0,15251677 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,09011752 0,15240463 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,09011752 0,15229265 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,09011752 0,15218083 ! cerebellum development GO:0021549 13 12 0,000 0,09011752 0,15206918 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,09011752 0,15195769 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,09011752 0,15184637 ! histone acetylation GO:0016573 23 12 0,000 0,09011752 0,15173521 ! histone methylation GO:0016571 15 12 0,000 0,09011752 0,15162421 ! autonomic nervous system development GO:0048483 23 12 0,000 0,09011752 0,15151337 ! gland morphogenesis GO:0022612 23 12 0,000 0,09011752 0,1514027 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,09011752 0,15129218 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,09011752 0,15118183 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,09011752 0,15107164 ! response to gamma radiation GO:0010332 20 12 0,000 0,09011752 0,15096161 ! regulation of epidermis development GO:0045682 17 12 0,000 0,09011752 0,15085174 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,09011752 0,15074203 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,09011752 0,15063248 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,09011752 0,15052309 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,09011752 0,15041386 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,09011752 0,15030478 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,09011752 0,15019586 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,09011752 0,15008711 ! microspike assembly GO:0030035 23 12 0,000 0,09011752 0,1499785 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,09011752 0,14987006 ! response to cold GO:0009409 14 12 0,000 0,09011752 0,14976177 ! reproductive structure development GO:0048608 90 65 1,000 0,09218284 0,15308342 ! regulation of caspase activity GO:0043281 97 65 1,000 0,09218284 0,15297297 ! appendage development GO:0048736 94 65 1,000 0,09218284 0,15286268 GO:0060173|limb development, ! cell-substrate adhesion GO:0031589 121 66 1,000 0,09459346 0,15674709 ! axon guidance GO:0007411 99 66 1,000 0,09459346 0,15663424 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,09459346 0,15652156 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,09702219 0,16042491 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,09725283 0,16069074 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09725283 0,16057538 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09725283 0,16046019 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09725283 0,16034517 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,09725283 0,16023031 ! water transport GO:0006833 17 13 0,000 0,09725283 0,16011561 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09725283 0,16000108 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09725283 0,15988671 ! lipid localization GO:0010876 24 13 0,000 0,09725283 0,15977251 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09725283 0,15965847 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09725283 0,15954459 ! organelle fusion GO:0048284 28 13 0,000 0,09725283 0,15943087 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09725283 0,15931732 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09725283 0,15920392 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09725283 0,15909069 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09725283 0,15897762 ! response to hexose stimulus GO:0009746 19 13 0,000 0,09725283 0,15886471 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,09725283 0,15875196 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09725283 0,15863937 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09725283 0,15852694 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09725283 0,15841467 ! NAD metabolic process GO:0019674 21 13 0,000 0,09725283 0,15830256 ! exocrine system development GO:0035272 27 13 0,000 0,09725283 0,1581906 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,09725283 0,15807881 ! bone mineralization GO:0030282 15 13 0,000 0,09725283 0,15796717 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09725283 0,15785569 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09725283 0,15774437 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09725283 0,1576332 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09725283 0,15752219 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,09725283 0,15741134 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,09725283 0,15730064 ! genitalia development GO:0048806 15 13 0,000 0,09725283 0,1571901 ! regulation of cellular pH GO:0030641 20 13 0,000 0,09725283 0,15707971 ! cellular pigmentation GO:0033059 24 13 0,000 0,09725283 0,15696948 ! tissue regeneration GO:0042246 21 13 0,000 0,09725283 0,1568594 ! cofactor transport GO:0051181 19 13 0,000 0,09725283 0,15674948 ! NADP metabolic process GO:0006739 18 13 0,000 0,09725283 0,15663971 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09725283 0,1565301 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09725283 0,15642064 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09725283 0,15631133 ! gas transport GO:0015669 18 13 0,000 0,09725283 0,15620217 ! regulation of RNA stability GO:0043487 28 13 0,000 0,09725283 0,15609317 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09725283 0,15598432 ! regulation of axon extension GO:0030516 23 13 0,000 0,09725283 0,15587562 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,09725283 0,15576707 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09725283 0,15565867 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09725283 0,15555042 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09725283 0,15544233 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09725283 0,15533438 ! response to drug GO:0042493 108 69 1,000 0,1019323 0,16269555 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,10433259 0,16641121 ! superoxide anion generation GO:0042554 18 14 0,000 0,10433259 0,16629589 ! neuron maturation GO:0042551 21 14 0,000 0,10433259 0,16618072 ! regulation of S phase GO:0033261 18 14 0,000 0,10433259 0,16606572 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,10433259 0,16595087 ! myotube differentiation GO:0014902 21 14 0,000 0,10433259 0,16583619 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,10433259 0,16572166 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,10433259 0,16560729 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,10433259 0,16549308 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,10433259 0,16537902 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,10433259 0,16526513 ! gene silencing by RNA GO:0031047 20 14 0,000 0,10433259 0,16515139 ! response to cAMP GO:0051591 19 14 0,000 0,10433259 0,1650378 ! limbic system development GO:0021761 25 14 0,000 0,10433259 0,16492437 ! startle response GO:0001964 21 14 0,000 0,10433259 0,1648111 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,10433259 0,16469798 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,10433259 0,16458502 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,10433259 0,16447222 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,10433259 0,16435956 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,10433259 0,16424707 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,10433259 0,16413472 ! glycine metabolic process GO:0006544 22 14 0,000 0,10433259 0,16402253 ! pituitary gland development GO:0021983 23 14 0,000 0,10433259 0,16391049 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,10433259 0,16379861 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,10433259 0,16368688 ! regulation of heart rate GO:0002027 23 14 0,000 0,10433259 0,1635753 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,10433259 0,16346387 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,10433259 0,1633526 ! embryo implantation GO:0007566 27 14 0,000 0,10433259 0,16324147 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,10433259 0,1631305 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,10433259 0,16301968 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,10433259 0,162909 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,10433259 0,16279848 ! axon cargo transport GO:0008088 27 14 0,000 0,10433259 0,16268811 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,10433259 0,16257789 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,10433259 0,16246782 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,10433259 0,16235789 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,10433259 0,16224812 ! mRNA splice site selection GO:0006376 26 14 0,000 0,10433259 0,16213849 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,10433259 0,16202901 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,10433259 0,16191968 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,10433259 0,16181049 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,10433259 0,16170146 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,10433259 0,16159257 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,10433259 0,16148382 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,10433259 0,16137523 ! muscle maintenance GO:0046716 19 14 0,000 0,10433259 0,16126678 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,10433259 0,16115847 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,10433259 0,16105031 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,10433259 0,1609423 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,10433259 0,16083443 ! cilium assembly GO:0042384 20 14 0,000 0,10433259 0,1607267 ! peptide hormone secretion GO:0030072 23 14 0,000 0,10433259 0,16061912 ! response to metal ion GO:0010038 103 70 1,000 0,10441283 0,16063513 ! regulation of catabolic process GO:0009894 106 70 1,000 0,10441283 0,16052775 ! muscle cell differentiation GO:0042692 104 71 1,000 0,1069098 0,16425688 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,1069098 0,16414723 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,10942281 0,16789357 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,10942281 0,16778164 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,10942281 0,16766986 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,11135723 0,1705204 ! positive regulation of cell size GO:0045793 20 15 0,000 0,11135723 0,17040695 ! metencephalon development GO:0022037 19 15 0,000 0,11135723 0,17029364 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,11135723 0,17018049 ! skin development GO:0043588 25 15 0,000 0,11135723 0,17006749 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,11135723 0,16995464 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,11135723 0,16984194 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,11135723 0,16972938 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,11135723 0,16961698 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,11135723 0,16950472 ! bile acid metabolic process GO:0008206 22 15 0,000 0,11135723 0,16939262 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,11135723 0,16928066 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,11135723 0,16916885 ! adult walking behavior GO:0007628 25 15 0,000 0,11135723 0,16905719 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,11135723 0,16894567 ! myoblast differentiation GO:0045445 27 15 0,000 0,11135723 0,1688343 ! centrosome cycle GO:0007098 16 15 0,000 0,11135723 0,16872308 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,11135723 0,16861201 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,11135723 0,16850108 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,11135723 0,16839029 ! cerebral cortex development GO:0021987 29 15 0,000 0,11135723 0,16827966 ! response to osmotic stress GO:0006970 22 15 0,000 0,11135723 0,16816917 ! vesicle coating GO:0006901 25 15 0,000 0,11135723 0,16805882 ! DNA integration GO:0015074 22 15 0,000 0,11135723 0,16794862 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,11135723 0,16783856 ! peptide secretion GO:0002790 27 15 0,000 0,11135723 0,16772864 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,11135723 0,16761887 ! regulation of vasodilation GO:0042312 24 15 0,000 0,11135723 0,16750925 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,11135723 0,16739976 ! neuron recognition GO:0008038 22 15 0,000 0,11135723 0,16729042 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,11135723 0,16718123 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,11135723 0,16707217 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,11135723 0,16696326 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,11135723 0,16685449 ! biomineral formation GO:0031214 18 15 0,000 0,11135723 0,16674586 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,11135723 0,16663737 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,11135723 0,16652902 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,11135723 0,16642082 ! dopamine metabolic process GO:0042417 30 15 0,000 0,11135723 0,16631275 ! organic cation transport GO:0015695 19 15 0,000 0,11135723 0,16620483 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,11135723 0,16609704 GO:0033014|tetrapyrrole biosynthetic process, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,11135723 0,1659894 ! defense response to virus GO:0051607 27 15 0,000 0,11135723 0,16588189 ! peptide hormone processing GO:0016486 19 15 0,000 0,11135723 0,16577452 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,11135723 0,1656673 ! regulation of blood pressure GO:0008217 107 73 1,000 0,11195145 0,16644365 ! digestion GO:0007586 97 74 1,000 0,11449533 0,1701158 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,11449533 0,17000597 ! blood coagulation GO:0007596 116 75 1,000 0,11705406 0,17369311 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 1,000 0,11705406 0,17358113 ! response to nutrient GO:0007584 104 75 1,000 0,11705406 0,17346928 ! regulation of ligase activity GO:0051340 114 75 1,000 0,11705406 0,17335758 ! protein secretion GO:0009306 27 16 0,000 0,11832718 0,17513032 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,11832718 0,1750177 ! hormone secretion GO:0046879 25 16 0,000 0,11832718 0,17490522 ! bone remodeling GO:0046849 24 16 0,000 0,11832718 0,17479288 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11832718 0,17468069 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,11832718 0,17456864 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11832718 0,17445674 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11832718 0,17434498 ! glial cell development GO:0021782 24 16 0,000 0,11832718 0,17423336 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11832718 0,17412189 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11832718 0,17401056 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11832718 0,17389937 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11832718 0,17378832 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11832718 0,17367742 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11832718 0,17356666 ! fructose metabolic process GO:0006000 20 16 0,000 0,11832718 0,17345603 ! regulation of protein binding GO:0043393 27 16 0,000 0,11832718 0,17334555 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11832718 0,17323521 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11832718 0,17312501 ! protein export from nucleus GO:0006611 24 16 0,000 0,11832718 0,17301495 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11832718 0,17290503 ! DNA replication initiation GO:0006270 25 16 0,000 0,11832718 0,17279525 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11832718 0,17268561 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11832718 0,1725761 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11832718 0,17246674 ! diencephalon development GO:0021536 25 16 0,000 0,11832718 0,17235751 ! oogenesis GO:0048477 23 16 0,000 0,11832718 0,17224843 ! neural crest cell migration GO:0001755 24 16 0,000 0,11832718 0,17213948 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11832718 0,17203067 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11832718 0,17192199 ! steroid catabolic process GO:0006706 22 16 0,000 0,11832718 0,17181346 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,11832718 0,17170506 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,11832718 0,17159679 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11832718 0,17148867 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11832718 0,17138068 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11832718 0,17127282 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11832718 0,1711651 ! nerve development GO:0021675 18 16 0,000 0,11832718 0,17105752 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11832718 0,17095007 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11832718 0,17084276 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,12221453 0,17634468 ! gland development GO:0048732 148 77 1,000 0,12221453 0,17623411 ! sex differentiation GO:0007548 105 77 1,000 0,12221453 0,17612369 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,12221453 0,17601341 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,12481552 0,17964686 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,12524286 0,1801492 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,12524286 0,1800366 ! negative regulation of defense response GO:0031348 19 17 0,000 0,12524286 0,17992415 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,12524286 0,17981184 ! glycerol metabolic process GO:0006071 20 17 0,000 0,12524286 0,17969967 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,12524286 0,17958764 GO:0019692|deoxyribose phosphate metabolic process, ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,12524286 0,17947574 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,12524286 0,17936399 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,12524286 0,17925238 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,12524286 0,1791409 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,12524286 0,17902956 ! keratinization GO:0031424 17 17 0,000 0,12524286 0,17891837 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,12524286 0,1788073 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,12524286 0,17869638 ! retinoid metabolic process GO:0001523 22 17 0,000 0,12524286 0,1785856 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,12524286 0,17847495 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,12524286 0,17836444 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,12524286 0,17825406 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,12524286 0,17814383 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,12524286 0,17803373 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,12524286 0,17792376 ! membrane budding GO:0006900 29 17 0,000 0,12524286 0,17781393 ! heme metabolic process GO:0042168 27 17 0,000 0,12524286 0,17770424 ! actin filament bundle formation GO:0051017 26 17 0,000 0,12524286 0,17759468 ! neuromuscular junction development GO:0007528 23 17 0,000 0,12524286 0,17748525 ! body fluid secretion GO:0007589 27 17 0,000 0,12524286 0,17737597 ! stem cell differentiation GO:0048863 36 17 0,000 0,12524286 0,17726681 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,12524286 0,17715779 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,12524286 0,1770489 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,12524286 0,17694015 ! sensory perception of pain GO:0019233 23 17 0,000 0,12524286 0,17683153 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,12524286 0,17672305 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,12524286 0,1766147 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,12524286 0,17650648 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,12524286 0,17639839 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,12524286 0,17629043 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,12524286 0,17618261 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,12524286 0,17607492 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,12524286 0,17596736 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,12524286 0,17585993 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,12524286 0,17575263 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,12524286 0,17564547 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,12742985 0,17860369 ! regulation of lyase activity GO:0051339 133 79 1,000 0,12742985 0,17849492 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,13210468 0,18493047 ! positive regulation of translation GO:0045727 28 18 0,000 0,13210468 0,18481798 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,13210468 0,18470563 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,13210468 0,18459341 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,13210468 0,18448134 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,13210468 0,18436939 ! cAMP metabolic process GO:0046058 33 18 0,000 0,13210468 0,18425759 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,13210468 0,18414591 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,13210468 0,18403438 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,13210468 0,18392298 ! axis specification GO:0009798 26 18 0,000 0,13210468 0,18381171 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,13210468 0,18370058 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,13210468 0,18358958 ! pancreas development GO:0031016 26 18 0,000 0,13210468 0,18347872 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,13210468 0,18336799 ! glutamine metabolic process GO:0006541 23 18 0,000 0,13210468 0,18325739 ! response to retinoic acid GO:0032526 25 18 0,000 0,13210468 0,18314693 ! central nervous system neuron development GO:0021954 30 18 0,000 0,13210468 0,1830366 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,13210468 0,18292641 ! fucose metabolic process GO:0006004 26 18 0,000 0,13210468 0,18281634 ! response to fungus GO:0009620 19 18 0,000 0,13210468 0,18270641 ! peptide cross-linking GO:0018149 31 18 0,000 0,13210468 0,18259661 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,13210468 0,18248694 ! heart process GO:0003015 27 18 0,000 0,13210468 0,18237741 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,13210468 0,182268 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,13210468 0,18215873 ! visual learning GO:0008542 35 18 0,000 0,13210468 0,18204959 ! somitogenesis GO:0001756 24 18 0,000 0,13210468 0,18194057 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,13210468 0,18183169 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,13210468 0,18172294 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,13210468 0,18161432 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,13210468 0,18150583 ! vitamin transport GO:0051180 24 18 0,000 0,13210468 0,18139747 ! hormone transport GO:0009914 27 18 0,000 0,13210468 0,18128924 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,13210468 0,18118113 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,13210468 0,18107316 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,13210468 0,18096531 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,13210468 0,18085759 ! cell-cell recognition GO:0009988 20 18 0,000 0,13210468 0,18075001 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,13210468 0,18064254 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,13210468 0,18053521 ! gut development GO:0048565 26 18 0,000 0,13210468 0,180428 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,13210468 0,18032093 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,13269708 0,18102212 ! hemostasis GO:0007599 125 81 1,000 0,13269708 0,18091481 ! regulation of neurological system process GO:0031644 122 81 1,000 0,13269708 0,18080764 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,13269708 0,18070059 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 1,000 0,13534927 0,18420315 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,13534927 0,18409422 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,13801337 0,18760683 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13891306 0,18871828 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,13891306 0,18860688 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13891306 0,1884956 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,13891306 0,18838446 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,13891306 0,18827345 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13891306 0,18816257 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13891306 0,18805182 ! regeneration GO:0031099 32 19 0,000 0,13891306 0,1879412 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13891306 0,18783072 ! response to alkaloid GO:0043279 32 19 0,000 0,13891306 0,18772036 ! sensory perception of taste GO:0050909 23 19 0,000 0,13891306 0,18761013 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13891306 0,18750003 ! peroxisome organization GO:0007031 29 19 0,000 0,13891306 0,18739006 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,13891306 0,18728022 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13891306 0,1871705 ! response to vitamin A GO:0033189 26 19 0,000 0,13891306 0,18706092 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13891306 0,18695146 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13891306 0,18684213 ! sex determination GO:0007530 29 19 0,000 0,13891306 0,18673293 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13891306 0,18662386 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,13891306 0,18651491 ! cytolysis GO:0019835 20 19 0,000 0,13891306 0,1864061 ! renal system process GO:0003014 35 19 0,000 0,13891306 0,1862974 ! vasodilation GO:0042311 33 19 0,000 0,13891306 0,18618884 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13891306 0,1860804 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13891306 0,18597209 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13891306 0,1858639 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,13891306 0,18575584 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,13891306 0,18564791 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13891306 0,1855401 ! sarcomere organization GO:0045214 23 19 0,000 0,13891306 0,18543241 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13891306 0,18532485 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13891306 0,18521742 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13891306 0,18511011 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13891306 0,18500292 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,13891306 0,18489586 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,13891306 0,18478892 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,13891306 0,18468211 ! rRNA metabolic process GO:0016072 107 85 1,000 0,14337593 0,19050527 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,14337593 0,19039528 ! regulation of membrane potential GO:0042391 128 85 1,000 0,14337593 0,19028542 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,14337593 0,19017568 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,14566843 0,19310512 ! iron ion transport GO:0006826 37 20 0,000 0,14566843 0,19299388 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,14566843 0,19288278 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,14566843 0,1927718 ! response to vitamin GO:0033273 29 20 0,000 0,14566843 0,19266095 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,14566843 0,19255022 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,14566843 0,19243962 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,14566843 0,19232915 ! spinal cord development GO:0021510 31 20 0,000 0,14566843 0,19221881 ! response to ethanol GO:0045471 37 20 0,000 0,14566843 0,19210859 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,14566843 0,1919985 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,14566843 0,19188854 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,14566843 0,1917787 ! chromosome condensation GO:0030261 31 20 0,000 0,14566843 0,19166898 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,14566843 0,1915594 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,14566843 0,19144993 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,14566843 0,1913406 ! pallium development GO:0021543 38 20 0,000 0,14566843 0,19123138 ! DNA modification GO:0006304 28 20 0,000 0,14566843 0,1911223 ! collagen fibril organization GO:0030199 45 20 0,000 0,14566843 0,19101333 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,14566843 0,19090449 ! collagen catabolic process GO:0030574 25 20 0,000 0,14566843 0,19079578 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,14566843 0,19068718 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,14566843 0,19057872 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,14566843 0,19047037 ! alditol metabolic process GO:0019400 24 20 0,000 0,14566843 0,19036215 ! actin filament-based movement GO:0030048 34 20 0,000 0,14566843 0,19025405 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,1460737 0,1906751 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,14878204 0,19410022 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,15237118 0,1986699 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,15237118 0,19855734 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,15237118 0,19844491 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,15237118 0,1983326 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,15237118 0,19822042 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,15237118 0,19810837 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,15237118 0,19799645 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,15237118 0,19788465 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,15237118 0,19777297 ! protein amino acid acylation GO:0043543 37 21 0,000 0,15237118 0,19766143 ! vesicle docking GO:0048278 27 21 0,000 0,15237118 0,19755001 ! dendrite development GO:0016358 35 21 0,000 0,15237118 0,19743871 ! visual behavior GO:0007632 39 21 0,000 0,15237118 0,19732754 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,15237118 0,19721649 ! ovarian follicle development GO:0001541 30 21 0,000 0,15237118 0,19710557 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,15237118 0,19699478 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,15237118 0,19688411 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,15237118 0,19677356 GO:0042278|purine nucleoside metabolic process, ! cell aging GO:0007569 32 21 0,000 0,15237118 0,19666314 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,15237118 0,19655284 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,15237118 0,19644266 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,15237118 0,19633261 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,15237118 0,19622268 GO:0060415|muscle tissue morphogenesis, ! leukotriene metabolic process GO:0006691 28 21 0,000 0,15237118 0,19611288 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,15237118 0,19600319 ! fatty acid transport GO:0015908 30 21 0,000 0,15237118 0,19589363 ! immunoglobulin production GO:0002377 33 21 0,000 0,15237118 0,1957842 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,15237118 0,19567488 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,15237118 0,19556569 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,15237118 0,19545661 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,15237118 0,19534766 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,15237118 0,19523884 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,15237118 0,19513013 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,15237118 0,19502154 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,15237118 0,19491308 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,15237118 0,19480473 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,15237118 0,19469651 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,15237118 0,1945884 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,15237118 0,19448042 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,15422907 0,19674258 ! reproductive developmental process GO:0003006 127 89 1,000 0,15422907 0,19663352 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,15422907 0,19652458 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,15902172 0,20251936 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,15902172 0,20240728 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,15902172 0,20229533 ! viral genome replication GO:0019079 29 22 0,000 0,15902172 0,20218351 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,15902172 0,2020718 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,15902172 0,20196022 ! molting cycle process GO:0022404 40 22 0,000 0,15902172 0,20184876 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,15902172 0,20173743 ! vasculogenesis GO:0001570 33 22 0,000 0,15902172 0,20162622 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,15902172 0,20151513 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,15902172 0,20140416 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,15902172 0,20129332 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,15902172 0,2011826 ! lysosome organization GO:0007040 37 22 0,000 0,15902172 0,201072 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,15902172 0,20096152 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,15902172 0,20085116 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,15902172 0,20074092 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,15902172 0,20063081 ! membrane depolarization GO:0051899 35 22 0,000 0,15902172 0,20052081 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,15902172 0,20041094 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,15902172 0,20030118 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,15902172 0,20019155 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,15902172 0,20008204 ! blastocyst development GO:0001824 37 22 0,000 0,15902172 0,19997264 ! neural tube closure GO:0001843 33 22 0,000 0,15902172 0,19986337 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,15902172 0,19975421 ! protein tetramerization GO:0051262 39 22 0,000 0,15902172 0,19964518 ! response to virus GO:0009615 122 91 1,000 0,15971446 0,20040549 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,16247075 0,20375285 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,1652357 0,20710742 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,16562046 0,20747662 ! neuron fate commitment GO:0048663 32 23 0,000 0,16562046 0,20736367 ! embryonic pattern specification GO:0009880 31 23 0,000 0,16562046 0,20725085 ! positive regulation of cell adhesion GO:0045785 37 23 0,000 0,16562046 0,20713815 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,16562046 0,20702558 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,16562046 0,20691313 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,16562046 0,2068008 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,16562046 0,20668859 ! vesicle targeting GO:0006903 32 23 0,000 0,16562046 0,2065765 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,16562046 0,20646453 ! osteoblast differentiation GO:0001649 40 23 0,000 0,16562046 0,20635269 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,16562046 0,20624097 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,16562046 0,20612936 ! interaction with host GO:0051701 37 23 0,000 0,16562046 0,20601788 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,16562046 0,20590652 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,16562046 0,20579528 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,16562046 0,20568416 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,16562046 0,20557316 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,16562046 0,20546228 ! cell fate determination GO:0001709 45 23 0,000 0,16562046 0,20535152 ! pentose metabolic process GO:0019321 31 23 0,000 0,16562046 0,20524088 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,16562046 0,20513035 ! spermatid development GO:0007286 33 23 0,000 0,16562046 0,20501995 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,16562046 0,20490966 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,16562046 0,2047995 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,16562046 0,20468945 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,16562046 0,20457952 ! telomere organization GO:0032200 32 23 0,000 0,16562046 0,20446971 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,16562046 0,20436001 ! regulation of amine transport GO:0051952 38 23 0,000 0,16562046 0,20425044 ! liver development GO:0001889 40 23 0,000 0,16562046 0,20414098 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,1721678 0,21209745 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,1721678 0,21198391 ! initiation of viral infection GO:0019059 42 24 0,000 0,1721678 0,21187049 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,1721678 0,21175719 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,1721678 0,21164401 ! superoxide metabolic process GO:0006801 32 24 0,000 0,1721678 0,21153095 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,1721678 0,21141802 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,1721678 0,2113052 ! sperm motility GO:0030317 27 24 0,000 0,1721678 0,2111925 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,1721678 0,21107993 ! vacuole organization GO:0007033 39 24 0,000 0,1721678 0,21096747 ! neural crest cell development GO:0014032 39 24 0,000 0,1721678 0,21085514 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,1721678 0,21074292 ! primary neural tube formation GO:0014020 35 24 0,000 0,1721678 0,21063082 ! negative regulation of cell development GO:0010721 56 24 0,000 0,1721678 0,21051884 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,1721678 0,21040699 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,1721678 0,21029524 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,1721678 0,21018362 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,1721678 0,21007212 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,1721678 0,20996073 ! protein amino acid glycosylation GO:0006486 134 97 1,000 0,17637608 0,2149788 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,17637608 0,21486493 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,17866414 0,21753707 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,17866414 0,21742197 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,17866414 0,21730699 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,17866414 0,21719213 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,17866414 0,2170774 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,17866414 0,21696279 ! peptide transport GO:0015833 43 25 0,000 0,17866414 0,21684829 ! male gonad development GO:0008584 33 25 0,000 0,17866414 0,21673392 ! iron ion homeostasis GO:0055072 39 25 0,000 0,17866414 0,21661967 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,17866414 0,21650554 ! phospholipid transport GO:0015914 35 25 0,000 0,17866414 0,21639153 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,17866414 0,21627764 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,17866414 0,21616387 ! leukocyte proliferation GO:0070661 39 25 0,000 0,17866414 0,21605022 GO:0032943|mononuclear cell proliferation, ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,18480788 0,22336213 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,18480788 0,22324482 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,18480788 0,22312763 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,18510986 0,22337496 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,18510986 0,22325783 ! translational initiation GO:0006413 43 26 0,000 0,18510986 0,22314082 ! regulation of pH GO:0006885 36 26 0,000 0,18510986 0,22302393 ! circadian rhythm GO:0007623 42 26 0,000 0,18510986 0,22290716 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,18510986 0,22279052 ! post-embryonic development GO:0009791 42 26 0,000 0,18510986 0,222674 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,18510986 0,2225576 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,18510986 0,22244132 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,18510986 0,22232516 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,18510986 0,22220912 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,18510986 0,22209321 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,18510986 0,22197742 ! regulation of coagulation GO:0050818 39 26 0,000 0,18510986 0,22186174 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,19150537 0,22940747 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,19150537 0,22928805 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,19150537 0,22916875 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,19150537 0,22904958 ! membrane docking GO:0022406 39 27 0,000 0,19150537 0,22893053 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,19150537 0,22881161 ! catechol metabolic process GO:0009712 43 27 0,000 0,19150537 0,22869281 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,19150537 0,22857413 ! acute-phase response GO:0006953 42 27 0,000 0,19150537 0,22845557 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,19150537 0,22833714 ! myofibril assembly GO:0030239 36 27 0,000 0,19150537 0,22821883 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,19150537 0,22810065 ! response to ionizing radiation GO:0010212 47 27 0,000 0,19150537 0,22798258 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,19150537 0,22786464 ! natural killer cell activation GO:0030101 35 27 0,000 0,19150537 0,22774682 ! lipid oxidation GO:0034440 38 27 0,000 0,19150537 0,22762912 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,19150537 0,22751154 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,19150537 0,22739409 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,19150537 0,22727675 ! gene silencing GO:0016458 41 27 0,000 0,19150537 0,22715954 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,19785104 0,23456567 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,19785104 0,23444482 ! phenol metabolic process GO:0018958 44 28 0,000 0,19785104 0,2343241 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,19785104 0,2342035 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,19785104 0,23408302 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,19785104 0,23396267 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,19785104 0,23384245 ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,19785104 0,23372234 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,19785104 0,23360236 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,19785104 0,2334825 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,19785104 0,23336277 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,19785104 0,23324316 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,19785104 0,23312367 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,19785104 0,2330043 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,19785104 0,23288506 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,19785104 0,23276593 ! neural tube formation GO:0001841 41 28 0,000 0,19785104 0,23264693 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,19785104 0,23252805 ! placenta development GO:0001890 37 28 0,000 0,19785104 0,23240929 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,20414727 0,23968286 ! regulation of innate immune response GO:0045088 38 29 0,000 0,20414727 0,23956058 ! ovulation cycle process GO:0022602 41 29 0,000 0,20414727 0,23943841 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,20414727 0,23931638 ! protein targeting to membrane GO:0006612 53 29 0,000 0,20414727 0,23919446 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,20414727 0,23907267 ! mismatch repair GO:0006298 34 29 0,000 0,20414727 0,23895101 ! muscle cell development GO:0055001 38 29 0,000 0,20414727 0,23882947 ! telencephalon development GO:0021537 52 29 0,000 0,20414727 0,23870805 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,20414727 0,23858675 ! eye morphogenesis GO:0048592 51 29 0,000 0,20414727 0,23846558 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,20414727 0,23834453 ! tissue homeostasis GO:0001894 42 29 0,000 0,20414727 0,23822361 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,21039444 0,24538905 ! collagen metabolic process GO:0032963 40 30 0,000 0,21039444 0,24526468 ! organic anion transport GO:0015711 51 30 0,000 0,21039444 0,24514043 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,21039444 0,24501631 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,21039444 0,24489232 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,21039444 0,24476844 ! ceramide metabolic process GO:0006672 43 30 0,000 0,21039444 0,2446447 ! ovulation cycle GO:0042698 43 30 0,000 0,21039444 0,24452108 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,21039444 0,24439758 ! adult locomotory behavior GO:0008344 47 30 0,000 0,21039444 0,24427421 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,21039444 0,24415097 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,21039444 0,24402784 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,21039444 0,24390485 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,21039444 0,24378197 ! mammary gland development GO:0030879 57 31 0,000 0,21659293 0,25083773 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,21659293 0,25071149 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,21659293 0,25058538 ! segmentation GO:0035282 41 31 0,000 0,21659293 0,25045939 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,21659293 0,25033353 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,21659293 0,2502078 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,21659293 0,25008219 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,21659293 0,24995671 ! cell fate specification GO:0001708 37 31 0,000 0,21659293 0,24983136 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,21659293 0,24970613 ! RNA modification GO:0009451 40 31 0,000 0,21659293 0,24958103 ! regulation of muscle development GO:0048634 48 32 0,000 0,22274311 0,25653938 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,22274311 0,25641098 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,22274311 0,25628271 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,22274311 0,25615457 ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,22274311 0,25602656 ! peripheral nervous system development GO:0007422 53 32 0,000 0,22274311 0,25589867 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,22274311 0,25577091 ! cytokine production GO:0001816 44 32 0,000 0,22274311 0,25564328 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,22274311 0,25551578 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,22274311 0,25538841 ! vesicle localization GO:0051648 47 32 0,000 0,22274311 0,25526116 ! RNA export from nucleus GO:0006405 44 33 0,000 0,22884535 0,26212366 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,22884535 0,26199318 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,22884535 0,26186284 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,22884535 0,26173262 ! ear morphogenesis GO:0042471 42 33 0,000 0,22884535 0,26160254 ! actomyosin structure organization GO:0031032 43 33 0,000 0,22884535 0,26147258 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,22884535 0,26134275 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,22884535 0,26121306 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,22884535 0,26108349 ! female gonad development GO:0008585 49 33 0,000 0,22884535 0,26095404 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,22884535 0,26082473 ! regulation of proteolysis GO:0030162 50 33 0,000 0,22884535 0,26069555 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,22884535 0,26056649 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,22884535 0,26043756 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,22884535 0,26030876 ! mRNA catabolic process GO:0006402 48 34 0,000 0,23490004 0,26706381 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,23490004 0,26693186 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,23490004 0,26680004 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,23490004 0,26666835 ! feeding behavior GO:0007631 45 34 0,000 0,23490004 0,26653679 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,23490004 0,26640537 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,23490004 0,26627407 ! neuron migration GO:0001764 46 34 0,000 0,23490004 0,2661429 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,23490004 0,26601186 ! female gamete generation GO:0007292 43 34 0,000 0,23490004 0,26588095 ! aerobic respiration GO:0009060 47 34 0,000 0,23490004 0,26575016 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,23490004 0,26561951 ! embryonic organ development GO:0048568 45 34 0,000 0,23490004 0,26548898 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,23490004 0,26535859 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,24090753 0,27201144 ! Notch signaling pathway GO:0007219 56 35 0,000 0,24090753 0,27187797 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,24090753 0,27174463 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,24090753 0,27161143 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,24090753 0,27147835 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,24090753 0,2713454 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,24090753 0,27121258 ! glycogen metabolic process GO:0005977 48 35 0,000 0,24090753 0,2710799 ! pigment metabolic process GO:0042440 61 35 0,000 0,24090753 0,27094734 ! protein homooligomerization GO:0051260 52 35 0,000 0,24090753 0,27081491 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,24686819 0,27737999 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 0,000 0,24686819 0,27724455 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,24686819 0,27710924 ! tissue remodeling GO:0048771 62 36 0,000 0,24686819 0,27697406 ! neural tube development GO:0021915 50 36 0,000 0,24686819 0,27683902 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,24686819 0,27670411 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,24686819 0,27656933 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,24686819 0,27643468 ! glucan metabolic process GO:0044042 49 36 0,000 0,24686819 0,27630016 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,25278238 0,28278185 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,25278238 0,28264438 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,25278238 0,28250704 ! ion transmembrane transport GO:0034220 56 37 0,000 0,25278238 0,28236983 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,25278238 0,28223276 ! regulation of protein secretion GO:0050708 51 37 0,000 0,25278238 0,28209582 ! amino acid activation GO:0043038 52 37 0,000 0,25278238 0,28195901 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,25278238 0,28182234 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,25865047 0,28822485 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,25865047 0,28808527 ! phagocytosis GO:0006909 60 38 0,000 0,25865047 0,28794583 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,26447281 0,29428518 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,26447281 0,29414288 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,26447281 0,29400071 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,26447281 0,29385868 ! male sex differentiation GO:0046661 53 39 0,000 0,26447281 0,29371679 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,26447281 0,29357503 ! chromatin remodeling GO:0006338 68 39 0,000 0,26447281 0,29343341 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,26447281 0,29329193 ! JNK cascade GO:0007254 54 39 0,000 0,26447281 0,29315059 ! developmental growth GO:0048589 62 39 0,000 0,26447281 0,29300938 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,27024976 0,2992655 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,27024976 0,29912148 ! regulation of tube size GO:0035150 60 40 0,000 0,27024976 0,2989776 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,27024976 0,29883386 ! peptide metabolic process GO:0006518 56 40 0,000 0,27024976 0,29869026 ! inner ear development GO:0048839 57 40 0,000 0,27024976 0,2985468 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,27024976 0,29840347 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,27024976 0,29826029 ! double-strand break repair GO:0006302 67 40 0,000 0,27024976 0,29811724 ! B cell differentiation GO:0030183 62 40 0,000 0,27024976 0,29797432 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,27024976 0,29783155 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,27598165 0,30400278 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,27598165 0,30385726 ! glucose transport GO:0015758 52 41 0,000 0,27598165 0,30371187 ! striated muscle contraction GO:0006941 62 41 0,000 0,27598165 0,30356662 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,27598165 0,30342151 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,27598165 0,30327654 ! biopolymer methylation GO:0043414 62 41 0,000 0,27598165 0,30313171 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,27598165 0,30298702 ! mitochondrial transport GO:0006839 60 42 0,000 0,28166886 0,30908319 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,28166886 0,3089358 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,28166886 0,30878855 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,28166886 0,30864144 ! hexose transport GO:0008645 54 42 0,000 0,28166886 0,30849446 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,28166886 0,30834763 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,28166886 0,30820094 ! excretion GO:0007588 63 42 0,000 0,28166886 0,30805439 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,28166886 0,30790797 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,28166886 0,3077617 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,28166886 0,30761556 ! regulation of cell shape GO:0008360 78 42 0,000 0,28166886 0,30746957 ! positive regulation of binding GO:0051099 59 43 0,000 0,28731171 0,31348052 ! neuromuscular process GO:0050905 79 43 0,000 0,28731171 0,31333188 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,28731171 0,31318338 ! tRNA processing GO:0008033 49 43 0,000 0,28731171 0,31303502 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,28731171 0,31288681 ! methylation GO:0032259 64 43 0,000 0,28731171 0,31273873 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,29291056 0,31868225 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,29291056 0,31853158 ! glycolysis GO:0006096 53 44 0,000 0,29291056 0,31838104 ! regulation of ion transport GO:0043269 57 44 0,000 0,29291056 0,31823065 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,29291056 0,3180804 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,29291056 0,31793029 ! RNA catabolic process GO:0006401 64 45 0,000 0,29846574 0,32380717 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,29846574 0,3236545 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,29846574 0,32350198 ! cell recognition GO:0008037 58 45 0,000 0,29846574 0,3233496 ! cell maturation GO:0048469 60 45 0,000 0,29846574 0,32319736 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,30397759 0,32901104 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,30397759 0,32885629 ! cell redox homeostasis GO:0045454 63 46 0,000 0,30397759 0,32870168 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,30397759 0,32854721 ! histone modification GO:0016570 68 46 0,000 0,30397759 0,32839289 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,30397759 0,32823872 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,30944646 0,33398726 ! viral infectious cycle GO:0019058 71 47 0,000 0,30944646 0,3338306 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,30944646 0,3336741 ! endocrine system development GO:0035270 83 47 0,000 0,30944646 0,33351774 ! covalent chromatin modification GO:0016569 75 47 0,000 0,30944646 0,33336152 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,30944646 0,33320545 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,30944646 0,33304953 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,30944646 0,33289375 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,30944646 0,33273812 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,30944646 0,33258264 ! chloride transport GO:0006821 67 48 0,000 0,31487266 0,33825647 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,31487266 0,33809856 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,31487266 0,33794079 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,31487266 0,33778317 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,31487266 0,33762569 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,31487266 0,33746837 ! regulation of endocytosis GO:0030100 63 48 0,000 0,31487266 0,33731118 ! nuclear export GO:0051168 69 48 0,000 0,31487266 0,33715415 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,31487266 0,33699726 ! regulation of angiogenesis GO:0045765 94 49 0,000 0,32025653 0,34260001 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,32025653 0,34244074 ! sensory perception of smell GO:0007608 61 49 0,000 0,32025653 0,34228161 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,32025653 0,34212263 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,32025653 0,3419638 ! RNA elongation GO:0006354 62 49 0,000 0,32025653 0,34180511 ! germ cell development GO:0007281 68 49 0,000 0,32025653 0,34164658 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,32025653 0,34148819 ! regulation of actin filament length GO:0030832 72 50 0,000 0,3255984 0,34702332 ! ear development GO:0043583 72 50 0,000 0,3255984 0,34686259 ! skeletal muscle fiber development GO:0048741 73 50 0,000 0,3255984 0,346702 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,3255984 0,34654157 ! positive regulation of growth GO:0045927 67 50 0,000 0,3255984 0,34638128 ! proton transport GO:0015992 75 50 0,000 0,3255984 0,34622114 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,3255984 0,34606115 ! hydrogen transport GO:0006818 77 51 0,000 0,3308986 0,351532 ! muscle fiber development GO:0048747 74 51 0,000 0,3308986 0,3513697 ! adult behavior GO:0030534 80 51 0,000 0,3308986 0,35120756 ! regulation of cellular component size GO:0032535 74 52 0,000 0,33615744 0,35662459 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,33615744 0,35646017 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,34137525 0,3618263 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,34137525 0,36165964 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,34137525 0,36149313 ! cell projection assembly GO:0030031 76 53 0,000 0,34137525 0,36132677 ! amino acid transport GO:0006865 84 54 0,000 0,34655235 0,36663772 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,34655235 0,36646915 ! glucose catabolic process GO:0006007 66 54 0,000 0,34655235 0,36630073 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,34655235 0,36613248 ! exocytosis GO:0006887 74 55 0,000 0,35168904 0,3713888 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,35168904 0,37121836 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,35168904 0,37104807 ! carbohydrate transport GO:0008643 74 57 0,000 0,36184248 0,38158538 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,36184248 0,3814105 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,36184248 0,38123578 ! camera-type eye development GO:0043010 88 57 0,000 0,36184248 0,38106122 ! secondary metabolic process GO:0019748 84 57 0,000 0,36184248 0,38088683 ! developmental maturation GO:0021700 75 57 0,000 0,36184248 0,38071259 ! gonad development GO:0008406 79 57 0,000 0,36184248 0,38053851 ! viral reproductive process GO:0022415 87 58 0,000 0,36685985 0,38563878 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,36685985 0,38546261 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,36685985 0,3852866 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,37183805 0,39033661 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,37183805 0,39015854 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,3767774 0,39516097 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,3767774 0,39498086 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,3767774 0,39480092 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,3767774 0,39462113 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,38167818 0,39957206 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,38167818 0,39939027 ! extracellular matrix organization GO:0030198 103 61 0,000 0,38167818 0,39920865 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,38167818 0,39902719 ! amine catabolic process GO:0009310 90 62 0,000 0,38654071 0,40392714 ! neurotransmitter transport GO:0006836 81 62 0,000 0,38654071 0,4037437 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,38654071 0,40356043 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,38654071 0,40337733 ! viral reproduction GO:0016032 92 63 0,000 0,39136527 0,40822682 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,39615217 0,41303263 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,39615217 0,41284549 ! hexose catabolic process GO:0019320 82 64 0,000 0,39615217 0,41265851 ! adaptive immune response GO:0002250 94 64 0,000 0,39615217 0,4124717 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! B cell activation GO:0042113 104 65 0,000 0,40090169 0,417228 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,40090169 0,4170393 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,40090169 0,41685076 ! defense response to bacterium GO:0042742 73 65 0,000 0,40090169 0,4166624 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,40090169 0,41647421 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,40090169 0,41628618 ! activation of immune response GO:0002253 83 65 0,000 0,40090169 0,41609833 ! protein oligomerization GO:0051259 100 65 0,000 0,40090169 0,41591064 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,40561413 0,42060978 ! antigen processing and presentation GO:0019882 96 66 0,000 0,40561413 0,42042023 ! regulation of immune effector process GO:0002697 101 66 0,000 0,40561413 0,42023085 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,41028976 0,42488359 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,41028976 0,42469237 ! acute inflammatory response GO:0002526 92 68 0,000 0,41492888 0,42930114 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,41492888 0,42910811 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,41492888 0,42891525 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,41492888 0,42872257 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,41492888 0,42853005 ! rhythmic process GO:0048511 105 68 0,000 0,41492888 0,42833772 ! inorganic anion transport GO:0015698 93 68 0,000 0,41492888 0,42814555 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,41953177 0,43270093 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,41953177 0,43250698 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,41953177 0,43231321 ! humoral immune response GO:0006959 86 70 0,000 0,42409871 0,43682358 ! eye development GO:0001654 111 70 0,000 0,42409871 0,43662804 ! amine transport GO:0015837 101 70 0,000 0,42409871 0,43643268 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,42862999 0,44089846 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,42862999 0,44070137 ! response to hypoxia GO:0001666 132 72 0,000 0,43312586 0,44512488 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,43758662 0,44950836 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,43758662 0,44930769 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,44201252 0,45364962 ! response to oxygen levels GO:0070482 137 74 0,000 0,44201252 0,45344728 ! protein import into nucleus GO:0006606 118 74 0,000 0,44201252 0,45324512 ! nuclear import GO:0051170 121 75 0,000 0,44640386 0,45754406 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,44640386 0,45734025 ! amine biosynthetic process GO:0009309 97 76 0,000 0,45076088 0,4615984 ! tRNA metabolic process GO:0006399 95 76 0,000 0,45076088 0,46139298 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,45076088 0,46118773 ! protein ubiquitination GO:0016567 125 77 0,000 0,45508385 0,46540368 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,45508385 0,46519683 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,45508385 0,46499017 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,45937305 0,46916431 ! cellular respiration GO:0045333 107 79 0,000 0,46362874 0,47330053 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,46362874 0,47309055 ! T cell activation GO:0042110 134 79 0,000 0,46362874 0,47288075 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,46362874 0,47267114 ! chromatin assembly GO:0031497 102 80 0,000 0,46785116 0,47676459 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,46785116 0,47655344 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,46785116 0,47634248 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,46785116 0,47613171 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,46785116 0,47592113 ! forebrain development GO:0030900 131 80 0,000 0,46785116 0,47571073 ! mRNA transport GO:0051028 121 81 0,000 0,47204059 0,47975844 ! vitamin metabolic process GO:0006766 103 81 0,000 0,47204059 0,47954653 ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,48032146 0,48774365 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,48441342 0,49168176 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,48847339 0,49558394 ! nucleosome organization GO:0034728 114 87 0,000 0,49649836 0,50350363 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,49649836 0,50328172 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,49649836 0,50306001 ! skeletal muscle tissue development GO:0007519 123 87 0,000 0,49649836 0,5028385 GO:0060538|skeletal muscle organ development, ! female pregnancy GO:0007565 130 87 0,000 0,49649836 0,50261718 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,50046385 0,50640865 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,50046385 0,50618596 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,50046385 0,50596346 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,50046385 0,50574115 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,50046385 0,50551904 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,50439834 0,50926961 ! leukocyte differentiation GO:0002521 143 90 0,000 0,50830206 0,51298585 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,50830206 0,51276085 ! RNA localization GO:0006403 135 91 0,000 0,51217526 0,51644151 ! ATP metabolic process GO:0046034 137 91 0,000 0,51217526 0,5162152 ! positive regulation of immune response GO:0050778 121 92 0,000 0,51601816 0,51986061 ! DNA recombination GO:0006310 146 92 0,000 0,51601816 0,519633 ! sulfur metabolic process GO:0006790 118 92 0,000 0,51601816 0,51940559 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,51983102 0,52301458 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,51983102 0,52278589 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,51983102 0,5225574 ! electron transport chain GO:0022900 123 94 0,000 0,52361405 0,52613032 ! response to oxidative stress GO:0006979 141 94 0,000 0,52361405 0,52590057 ! carboxylic acid transport GO:0046942 147 95 0,000 0,52736749 0,52943921 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,53109158 0,5329453 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,53109158 0,53271288 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,53109158 0,53248066 ! protein maturation GO:0051604 129 96 0,000 0,53109158 0,53224864 ! calcium ion transport GO:0006816 167 99 0,000 0,54208995 0,54303435 ! protein import GO:0017038 156 99 0,000 0,54208995 0,54279794 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,54569885 0,54617379 ! divalent metal ion transport GO:0070838 171 100 0,000 0,54569885 0,54593622 ! protein localization in organelle GO:0033365 161 100 0,000 0,54569885 0,54569885