pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6286-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! induction of positive chemotaxis GO:0050930 14 8 3,000 6,546E-09 1,506E-05 ! regulation of positive chemotaxis GO:0050926 17 11 3,000 3,064E-08 3,523E-05 GO:0050927|positive regulation of positive chemotaxis, ! positive regulation of locomotion GO:0040017 35 20 3,000 4,403E-07 3,376E-04 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! regulation of chemotaxis GO:0050920 36 21 3,000 5,426E-07 3,12E-04 ! regulation of behavior GO:0050795 38 22 3,000 6,616E-07 3,043E-04 ! negative regulation of phosphorylation GO:0042326 41 23 3,000 7,99E-07 3,063E-04 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,08E-06 3,548E-04 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 3,000 1,136E-06 3,266E-04 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 2,58E-06 6,593E-04 ! chondrocyte differentiation GO:0002062 17 11 2,000 5,045E-06 1,16E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 5,045E-06 1,055E-03 GO:0010829|negative regulation of glucose transport, ! positive regulation of response to external stimulus GO:0032103 65 40 3,000 7,919E-06 1,518E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 7,919E-06 1,401E-03 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 2,000 8,704E-06 1,43E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,378E-05 2,114E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,693E-05 2,433E-03 ! cartilage development GO:0051216 70 49 3,000 1,797E-05 2,431E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,051E-05 2,62E-03 ! regulation of glucose import GO:0046324 21 18 2,000 2,455E-05 2,972E-03 GO:0010827|regulation of glucose transport, ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 2,909E-05 3,345E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 3,287E-05 3,6E-03 ! positive regulation of inflammatory response GO:0050729 30 20 2,000 3,415E-05 3,57E-03 ! negative regulation of kinase activity GO:0033673 100 58 3,000 3,522E-05 3,522E-03 ! negative regulation of transferase activity GO:0051348 105 61 3,000 4,302E-05 4,123E-03 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 4,887E-05 4,496E-03 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 7,398E-05 6,545E-03 ! negative regulation of protein modification process GO:0031400 50 26 2,000 7,683E-05 6,544E-03 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 8,262E-05 6,787E-03 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 9,636E-05 7,642E-03 ! negative regulation of bone resorption GO:0045779 10 5 1,000 1,002E-04 7,679E-03 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 1,002E-04 7,431E-03 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,313E-04 9,439E-03 GO:0060326|cell chemotaxis, ! oligosaccharide biosynthetic process GO:0009312 8 6 1,000 1,499E-04 0,01045005 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,499E-04 0,01014269 ! mRNA stabilization GO:0048255 15 6 1,000 1,499E-04 9,853E-03 GO:0043489|RNA stabilization, ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 1,000 1,499E-04 9,579E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 2,095E-04 0,01302159 ! T-helper 1 type immune response GO:0042088 11 7 1,000 2,095E-04 0,01267891 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 2,095E-04 0,01235381 ! regulation of response to external stimulus GO:0032101 139 96 3,000 2,52E-04 0,01449069 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 2,622E-04 0,01470819 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 2,787E-04 0,01526373 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 2,787E-04 0,01490876 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 2,787E-04 0,01456992 ! regulation of vascular permeability GO:0043114 12 8 1,000 2,787E-04 0,01424615 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 2,787E-04 0,01393645 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 2,787E-04 0,01363993 ! retinal ganglion cell axon guidance GO:0031290 10 8 1,000 2,787E-04 0,01335576 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 1,000 2,787E-04 0,0130832 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 3,509E-04 0,01613934 ! leukocyte migration GO:0050900 60 43 2,000 3,509E-04 0,01582288 ! lung alveolus development GO:0048286 17 9 1,000 3,576E-04 0,01581819 ! ventral spinal cord development GO:0021517 11 9 1,000 3,576E-04 0,01551974 ! motor axon guidance GO:0008045 14 9 1,000 3,576E-04 0,01523234 ! localization within membrane GO:0051668 15 9 1,000 3,576E-04 0,01495538 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 3,757E-04 0,01542951 ! regulation of inflammatory response GO:0050727 60 44 2,000 3,757E-04 0,01515881 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 3,757E-04 0,01489746 ! positive regulation of cell cycle GO:0045787 77 45 2,000 4,016E-04 0,0156555 ! positive regulation of defense response GO:0031349 59 45 2,000 4,016E-04 0,01539457 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 4,016E-04 0,0151422 ! histone modification GO:0016570 68 46 2,000 4,286E-04 0,01590129 ! response to UV GO:0009411 75 46 2,000 4,286E-04 0,01564889 ! regulation of B cell proliferation GO:0030888 15 10 1,000 4,461E-04 0,01603232 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 4,461E-04 0,01578567 ! blood vessel remodeling GO:0001974 21 10 1,000 4,461E-04 0,01554649 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 4,461E-04 0,01531445 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 4,461E-04 0,01508924 ! regulation of bone resorption GO:0045124 24 10 1,000 4,461E-04 0,01487056 ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 4,461E-04 0,01465812 ! covalent chromatin modification GO:0016569 75 47 2,000 4,568E-04 0,01479881 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 4,568E-04 0,01459327 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of muscle contraction GO:0006937 69 48 2,000 4,862E-04 0,01531817 ! integrin-mediated signaling pathway GO:0007229 81 49 2,000 5,167E-04 0,01606025 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 5,441E-04 0,01668674 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 1,000 5,441E-04 0,01646717 ! histone deacetylation GO:0016575 13 11 1,000 5,441E-04 0,01625331 ! regulation of leukocyte migration GO:0002685 24 11 1,000 5,441E-04 0,01604494 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 5,441E-04 0,01584184 GO:0042130|negative regulation of T cell proliferation, ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 5,814E-04 0,01671582 ! positive regulation of cell migration GO:0030335 92 51 2,000 5,814E-04 0,01650945 ! cartilage condensation GO:0001502 18 12 1,000 6,516E-04 0,01827706 ! histone acetylation GO:0016573 23 12 1,000 6,516E-04 0,01805686 ! peptidyl-lysine modification GO:0018205 18 12 1,000 6,516E-04 0,0178419 ! regulation of mRNA stability GO:0043488 27 12 1,000 6,516E-04 0,01763199 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 6,516E-04 0,01742697 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 7,652E-04 0,02022971 ! positive regulation of cell motion GO:0051272 99 56 2,000 7,652E-04 0,01999982 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 7,685E-04 0,01986038 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 7,685E-04 0,01963971 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 7,685E-04 0,01942389 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 7,685E-04 0,01921276 ! regulation of RNA stability GO:0043487 28 13 1,000 7,685E-04 0,01900617 ! lung development GO:0030324 94 59 2,000 8,913E-04 0,02180934 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 8,948E-04 0,02166245 ! regulation of heart contraction GO:0008016 91 60 2,000 9,361E-04 0,02242812 ! cell-matrix adhesion GO:0007160 114 61 2,000 9,823E-04 0,02329226 ! respiratory tube development GO:0030323 99 62 2,000 1,03E-03 0,0241721 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 1,03E-03 0,02393596 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 1,03E-03 0,0236966 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 1,13E-03 0,02572135 ! respiratory system development GO:0060541 100 64 2,000 1,13E-03 0,02546918 ! protein amino acid deacetylation GO:0006476 20 16 1,000 1,175E-03 0,02623904 ! protein amino acid acetylation GO:0006473 28 16 1,000 1,175E-03 0,02598674 ! neural crest cell migration GO:0001755 24 16 1,000 1,175E-03 0,02573924 ! defense response to bacterium GO:0042742 73 65 2,000 1,181E-03 0,02563592 ! cell-substrate adhesion GO:0031589 121 66 2,000 1,235E-03 0,02654558 ! axon guidance GO:0007411 99 66 2,000 1,235E-03 0,02629979 ! oligosaccharide metabolic process GO:0009311 26 17 1,000 1,329E-03 0,02804295 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 1,329E-03 0,02778801 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 1,329E-03 0,02753767 ! neuromuscular junction development GO:0007528 23 17 1,000 1,329E-03 0,0272918 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 1,329E-03 0,02705027 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 1,000 1,492E-03 0,03010269 ! pancreas development GO:0031016 26 18 1,000 1,492E-03 0,02984093 ! somitogenesis GO:0001756 24 18 1,000 1,492E-03 0,02958368 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 1,492E-03 0,02933083 ! negative regulation of T cell activation GO:0050868 25 18 1,000 1,492E-03 0,02908226 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 1,525E-03 0,02947737 ! response to hypoxia GO:0001666 132 72 2,000 1,588E-03 0,03043382 ! negative regulation of transport GO:0051051 116 73 2,000 1,652E-03 0,03140479 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 1,664E-03 0,03137349 ! vesicle docking during exocytosis GO:0006904 24 19 1,000 1,664E-03 0,03111842 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 1,664E-03 0,03086746 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,664E-03 0,03062052 ! response to oxygen levels GO:0070482 137 74 2,000 1,718E-03 0,03136194 ! spinal cord development GO:0021510 31 20 1,000 1,845E-03 0,0334183 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 1,845E-03 0,03315722 ! positive regulation of B cell activation GO:0050871 31 20 1,000 1,845E-03 0,03290019 ! positive regulation of protein modification process GO:0031401 107 78 2,000 1,998E-03 0,03535236 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 2,035E-03 0,03573474 ! protein amino acid acylation GO:0043543 37 21 1,000 2,035E-03 0,03546402 ! vesicle docking GO:0048278 27 21 1,000 2,035E-03 0,03519737 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 2,035E-03 0,03493471 ! chromatin assembly GO:0031497 102 80 2,000 2,148E-03 0,03659988 GO:0006334|nucleosome assembly, ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 2,234E-03 0,0377854 ! vasculogenesis GO:0001570 33 22 1,000 2,234E-03 0,03750959 ! ossification GO:0001503 134 82 2,000 2,305E-03 0,03841943 GO:0060348|bone development, ! neuron fate commitment GO:0048663 32 23 1,000 2,442E-03 0,0404078 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 2,442E-03 0,04011917 ! myelination GO:0042552 35 23 1,000 2,442E-03 0,03983464 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 2,442E-03 0,03955411 ! regulation of defense response GO:0031347 117 84 2,000 2,469E-03 0,03971149 ! protein-DNA complex assembly GO:0065004 107 84 2,000 2,469E-03 0,03943571 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 2,554E-03 0,04050507 ! interphase of mitotic cell cycle GO:0051329 156 86 2,000 2,64E-03 0,04158771 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 2,659E-03 0,0415968 ! neural crest cell development GO:0014032 39 24 1,000 2,659E-03 0,04131574 GO:0014033|neural crest cell differentiation, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 1,000 2,659E-03 0,04103846 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 2,659E-03 0,04076487 ! nucleosome organization GO:0034728 114 87 2,000 2,728E-03 0,04155289 ! skeletal muscle tissue development GO:0007519 123 87 2,000 2,728E-03 0,04127952 GO:0060538|skeletal muscle organ development, ! interphase GO:0051325 159 88 2,000 2,818E-03 0,04236146 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 2,884E-03 0,04307028 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 2,884E-03 0,0427924 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 3,118E-03 0,04596688 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 3,118E-03 0,0456741 ! membrane docking GO:0022406 39 27 1,000 3,36E-03 0,0489154 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 3,36E-03 0,04860775 ! angiogenesis GO:0001525 149 95 2,000 3,499E-03 0,05029474 ! response to light stimulus GO:0009416 153 96 2,000 3,603E-03 0,05147855 ! ensheathment of neurons GO:0007272 43 28 1,000 3,611E-03 0,05127219 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 1,000 3,611E-03 0,05095764 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 3,871E-03 0,05428714 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 3,929E-03 0,05477007 ! homophilic cell adhesion GO:0007156 149 100 2,000 4,042E-03 0,05599758 ! negative regulation of cell activation GO:0050866 44 30 1,000 4,139E-03 0,05700297 ! mammary gland development GO:0030879 57 31 1,000 4,415E-03 0,06044752 ! segmentation GO:0035282 41 31 1,000 4,415E-03 0,06008984 ! peripheral nervous system development GO:0007422 53 32 1,000 4,7E-03 0,06358839 ! calcium-mediated signaling GO:0019722 50 32 1,000 4,7E-03 0,06321653 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 5,294E-03 0,07079469 ! neuron migration GO:0001764 46 34 1,000 5,294E-03 0,07038547 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 5,604E-03 0,07407043 ! regulation of action potential in neuron GO:0019228 54 35 1,000 5,604E-03 0,07364717 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 5,604E-03 0,07322872 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 5,604E-03 0,072815 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 5,921E-03 0,07650834 GO:0090047|positive regulation of transcription regulator activity, ! tissue remodeling GO:0048771 62 36 1,000 5,921E-03 0,07608092 ! regulation of T cell proliferation GO:0042129 58 38 1,000 6,58E-03 0,08408022 ! mesenchymal cell development GO:0014031 64 38 1,000 6,58E-03 0,08361569 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! synapse organization GO:0050808 55 39 1,000 6,922E-03 0,08747209 ! positive regulation of protein transport GO:0051222 55 40 1,000 7,271E-03 0,09138566 ! positive regulation of DNA binding GO:0043388 57 41 1,000 7,628E-03 0,09535482 ! regulation of T cell differentiation GO:0045580 59 41 1,000 7,628E-03 0,09483939 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 7,993E-03 0,09884373 ! regulation of cell shape GO:0008360 78 42 1,000 7,993E-03 0,09831515 ! positive regulation of binding GO:0051099 59 43 1,000 8,366E-03 0,10235316 ! regulation of action potential GO:0001508 71 44 1,000 8,747E-03 0,10644208 ! vascular process in circulatory system GO:0003018 69 45 1,000 9,135E-03 0,11058049 ! negative regulation of immune system process GO:0002683 73 47 1,000 9,934E-03 0,11962324 ! heart morphogenesis GO:0003007 65 48 1,000 0,0103447 0,1239209 ! nuclear export GO:0051168 69 48 1,000 0,0103447 0,12327883 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,0103447 0,12264337 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,01076291 0,12694718 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,01076291 0,12629949 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,01118852 0,13062734 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,01162146 0,13499674 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,01162146 0,13431836 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,01206169 0,13870946 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,01250917 0,14313972 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,01250917 0,14243111 ! regulation of protein complex assembly GO:0043254 81 54 1,000 0,01296383 0,14688088 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,01296383 0,14616087 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,01296383 0,14544789 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,01296383 0,14474183 ! exocytosis GO:0006887 74 55 1,000 0,01342564 0,14917382 ! viral reproductive process GO:0022415 87 58 1,000 0,01485345 0,16424487 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,01584015 0,17431742 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,015916 0,1743181 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,015916 0,17349195 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,015916 0,17267359 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,015916 0,17186292 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,015916 0,17105982 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,015916 0,17026419 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,015916 0,16947593 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,015916 0,16869494 ! sleep GO:0030431 11 5 0,000 0,015916 0,16792111 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,015916 0,16715434 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,015916 0,16639455 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,015916 0,16564163 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,015916 0,1648955 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,015916 0,16415606 ! tongue development GO:0043586 6 5 0,000 0,015916 0,16342322 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,015916 0,16269689 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,015916 0,161977 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,015916 0,16126344 ! cobalt ion transport GO:0006824 9 5 0,000 0,015916 0,16055615 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,015916 0,15985503 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,015916 0,15916001 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,015916 0,158471 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,015916 0,15778794 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,015916 0,15711074 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,015916 0,15643932 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,015916 0,15577362 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,015916 0,15511356 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,015916 0,15445908 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,015916 0,15381009 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,015916 0,15316653 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,015916 0,15252834 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,015916 0,15189544 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,015916 0,15126777 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,015916 0,15064527 ! malate metabolic process GO:0006108 7 5 0,000 0,015916 0,15002787 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,015916 0,14941552 ! behavioral response to pain GO:0048266 7 5 0,000 0,015916 0,14880814 ! clathrin coat assembly GO:0048268 11 5 0,000 0,015916 0,14820567 ! phototransduction, visible light GO:0007603 6 5 0,000 0,015916 0,14760807 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,015916 0,14701527 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,015916 0,14642721 ! mating behavior GO:0007617 6 5 0,000 0,015916 0,14584383 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,015916 0,14526508 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,015916 0,14469091 ! rhythmic behavior GO:0007622 12 5 0,000 0,015916 0,14412126 ! copulation GO:0007620 7 5 0,000 0,015916 0,14355608 ! glial cell fate commitment GO:0021781 12 5 0,000 0,015916 0,14299532 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,015916 0,14243892 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,015916 0,14188683 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,015916 0,141339 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,015916 0,14079539 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,015916 0,14025594 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,015916 0,13972062 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,015916 0,13918936 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,015916 0,13866213 ! response to protozoan GO:0001562 9 5 0,000 0,015916 0,13813887 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,015916 0,13761955 ! lymph vessel development GO:0001945 7 5 0,000 0,015916 0,13710412 ! endochondral ossification GO:0001958 12 5 0,000 0,015916 0,13659254 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,015916 0,13608476 ! parathyroid gland development GO:0060017 8 5 0,000 0,015916 0,13558075 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,015916 0,13508045 ! anagen GO:0042640 6 5 0,000 0,015916 0,13458383 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,015916 0,13409085 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,015916 0,13360146 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,015916 0,13311564 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,015916 0,13263334 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,015916 0,13215452 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,015916 0,13167914 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,015916 0,13120717 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,015916 0,13073858 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,015916 0,13027331 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,015916 0,12981135 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,015916 0,12935265 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,015916 0,12889719 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,015916 0,12844492 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,015916 0,12799581 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,015916 0,12754983 ! ovulation GO:0030728 6 5 0,000 0,015916 0,12710695 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,015916 0,12666713 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,015916 0,12623035 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,015916 0,12579657 ! response to pH GO:0009268 9 5 0,000 0,015916 0,12536576 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,015916 0,12493789 ! proline biosynthetic process GO:0006561 6 5 0,000 0,015916 0,12451293 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,015916 0,12409085 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,015916 0,12367163 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,015916 0,12325522 ! polyol catabolic process GO:0046174 7 5 0,000 0,015916 0,12284162 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,015916 0,12243077 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,015916 0,12202267 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,015916 0,12161728 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,015916 0,12121457 ! nerve growth factor processing GO:0032455 7 5 0,000 0,015916 0,12081453 ! urea metabolic process GO:0019627 6 5 0,000 0,015916 0,12041711 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,015916 0,1200223 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,015916 0,11963007 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,015916 0,1192404 ! neutrophil activation GO:0042119 5 5 0,000 0,015916 0,11885325 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,015916 0,11846861 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,015916 0,11808646 ! response to food GO:0032094 5 5 0,000 0,015916 0,11770676 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,015916 0,11732949 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,015916 0,11695464 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,015916 0,11658217 ! forebrain neuron development GO:0021884 7 5 0,000 0,015916 0,11621207 ! melanosome organization GO:0032438 7 5 0,000 0,015916 0,11584431 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,015916 0,11547887 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,015916 0,11511573 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,015916 0,11475486 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,015916 0,11439625 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,015916 0,11403988 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,015916 0,11368572 ! nucleoside transport GO:0015858 6 5 0,000 0,015916 0,11333375 ! nucleoside salvage GO:0043174 7 5 0,000 0,015916 0,11298395 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,015916 0,11263631 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,015916 0,1122908 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,015916 0,1119474 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,015916 0,1116061 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,015916 0,11126687 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,015916 0,1109297 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,015916 0,11059457 ! depyrimidination GO:0045008 8 5 0,000 0,015916 0,11026145 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,015916 0,10993033 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,015916 0,1096012 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,015916 0,10927403 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,015916 0,10894881 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,015916 0,10862552 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,015916 0,10830415 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,015916 0,10798466 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,015916 0,10766706 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,015916 0,10735132 ! monocyte differentiation GO:0030224 8 5 0,000 0,015916 0,10703743 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,015916 0,10672537 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,015916 0,10641512 ! centrosome duplication GO:0051298 5 5 0,000 0,015916 0,10610667 ! response to UV-C GO:0010225 6 5 0,000 0,015916 0,1058 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,015916 0,1054951 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,015916 0,10519196 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,015916 0,10489055 ! regulation of dendrite development GO:0050773 12 5 0,000 0,015916 0,10459086 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,015916 0,10429288 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,015916 0,10399659 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,015916 0,10370199 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,015916 0,10340904 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,015916 0,10311775 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,015916 0,10282809 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,015916 0,10254006 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,015916 0,10225363 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,015916 0,10196881 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,015916 0,10168556 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,015916 0,10140388 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,015916 0,10112376 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,015916 0,10084518 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,015916 0,10056814 ! neural tube patterning GO:0021532 6 5 0,000 0,015916 0,10029261 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,015916 0,10001858 ! histone demethylation GO:0016577 9 5 0,000 0,015916 0,09974605 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,015916 0,099475 ! regulation of sterol transport GO:0032371 7 5 0,000 0,015916 0,09920542 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,015916 0,0989373 ! enteric nervous system development GO:0048484 8 5 0,000 0,015916 0,09867062 ! establishment of planar polarity GO:0001736 6 5 0,000 0,015916 0,09840538 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,015916 0,09814156 ! muscle cell proliferation GO:0033002 8 5 0,000 0,015916 0,09787915 ! transcription termination GO:0006353 8 5 0,000 0,015916 0,09761814 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,015916 0,09735851 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,015916 0,09710027 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,015916 0,09684339 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,015916 0,09658787 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,015916 0,09633369 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,015916 0,09608084 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,015916 0,09582932 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,015916 0,09557912 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,015916 0,09533021 ! apical protein localization GO:0045176 6 5 0,000 0,015916 0,0950826 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,015916 0,09483627 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,015916 0,09459122 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,015916 0,09434743 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,015916 0,09410489 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,015916 0,09386359 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,015916 0,09362353 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,015916 0,0933847 ! glial cell migration GO:0008347 10 5 0,000 0,015916 0,09314708 ! determination of adult lifespan GO:0008340 8 5 0,000 0,015916 0,09291066 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,015916 0,09267545 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,015916 0,09244142 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,015916 0,09220857 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,015916 0,09197689 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,015916 0,09174637 ! neural plate development GO:0001840 6 5 0,000 0,015916 0,091517 ! regulation of sensory perception GO:0051931 6 5 0,000 0,015916 0,09128878 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,015916 0,09106169 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,015916 0,09083574 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,015916 0,09061089 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,015916 0,09038716 ! sensory cilium assembly GO:0035058 6 5 0,000 0,015916 0,09016454 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,015916 0,089943 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,015916 0,08972255 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,015916 0,08950318 ! spindle assembly GO:0051225 5 5 0,000 0,015916 0,08928488 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,015916 0,08906764 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,015916 0,08885146 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,015916 0,08863632 ! organ regeneration GO:0031100 7 5 0,000 0,015916 0,08842223 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,015916 0,08820916 ! carnitine metabolic process GO:0009437 5 5 0,000 0,015916 0,08799712 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,015916 0,08778609 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,015916 0,08757608 GO:0055081|anion homeostasis, ! negative regulation of cell growth GO:0030308 106 62 1,000 0,01685427 0,09251745 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,01737149 0,09512957 GO:0090046|regulation of transcription regulator activity, ! viral reproduction GO:0016032 92 63 1,000 0,01737149 0,09490361 ! regulation of lipase activity GO:0060191 109 63 1,000 0,01737149 0,09467872 ! negative regulation of cell size GO:0045792 108 64 1,000 0,01789542 0,09730371 ! adaptive immune response GO:0002250 94 64 1,000 0,01789542 0,09707422 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of caspase activity GO:0043281 97 65 1,000 0,01842602 0,0997173 ! protein oligomerization GO:0051259 100 65 1,000 0,01842602 0,09948323 ! tRNA transcription GO:0009304 11 6 0,000 0,01906921 0,10271473 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01906921 0,10247475 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01906921 0,10223588 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01906921 0,10199812 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01906921 0,10176146 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01906921 0,10152591 ! regulation of helicase activity GO:0051095 11 6 0,000 0,01906921 0,10129143 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01906921 0,10105804 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01906921 0,10082573 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01906921 0,10059448 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01906921 0,10036428 ! prostate gland development GO:0030850 9 6 0,000 0,01906921 0,10013514 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01906921 0,09990704 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01906921 0,09967998 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01906921 0,09945395 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01906921 0,09922894 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01906921 0,09900495 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01906921 0,09878196 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01906921 0,09855998 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01906921 0,09833899 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01906921 0,098119 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,01906921 0,09789998 ! neuron adhesion GO:0007158 9 6 0,000 0,01906921 0,09768194 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01906921 0,09746487 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01906921 0,09724876 ! signal peptide processing GO:0006465 8 6 0,000 0,01906921 0,09703361 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01906921 0,09681941 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01906921 0,09660615 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01906921 0,09639383 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01906921 0,09618244 ! opsonization GO:0008228 8 6 0,000 0,01906921 0,09597197 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01906921 0,09576243 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01906921 0,09555379 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01906921 0,09534607 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01906921 0,09513924 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01906921 0,09493331 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01906921 0,09472827 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01906921 0,09452412 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01906921 0,09432084 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01906921 0,09411844 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01906921 0,0939169 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01906921 0,09371622 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01906921 0,0935164 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01906921 0,09331743 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01906921 0,0931193 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01906921 0,09292202 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01906921 0,09272556 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01906921 0,09252994 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01906921 0,09233514 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01906921 0,09214116 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01906921 0,09194799 ! thymic T cell selection GO:0045061 12 6 0,000 0,01906921 0,09175563 ! protein lipoylation GO:0009249 10 6 0,000 0,01906921 0,09156407 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01906921 0,09137332 ! pigment granule organization GO:0048753 11 6 0,000 0,01906921 0,09118335 ! drug transport GO:0015893 6 6 0,000 0,01906921 0,09099417 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01906921 0,09080578 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,01906921 0,09061816 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01906921 0,09043132 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01906921 0,09024525 ! histidine metabolic process GO:0006547 6 6 0,000 0,01906921 0,09005994 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01906921 0,08987539 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01906921 0,0896916 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01906921 0,08950855 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01906921 0,08932626 ! adenohypophysis development GO:0021984 10 6 0,000 0,01906921 0,0891447 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01906921 0,08896388 ! hyperosmotic response GO:0006972 8 6 0,000 0,01906921 0,08878379 ! microtubule nucleation GO:0007020 10 6 0,000 0,01906921 0,08860443 ! ER overload response GO:0006983 7 6 0,000 0,01906921 0,08842579 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01906921 0,08824787 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01906921 0,08807067 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01906921 0,08789417 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01906921 0,08771838 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01906921 0,0875433 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01906921 0,08736891 ! response to dietary excess GO:0002021 7 6 0,000 0,01906921 0,08719521 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01906921 0,0870222 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01906921 0,08684988 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01906921 0,08667824 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01906921 0,08650728 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01906921 0,08633699 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01906921 0,08616737 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01906921 0,08599841 ! neuron apoptosis GO:0051402 8 6 0,000 0,01906921 0,08583012 ! organic alcohol transport GO:0015850 9 6 0,000 0,01906921 0,08566248 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01906921 0,0854955 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01906921 0,08532917 ! male sex determination GO:0030238 9 6 0,000 0,01906921 0,08516348 ! carnitine transport GO:0015879 8 6 0,000 0,01906921 0,08499843 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01906921 0,08483403 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01906921 0,08467025 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01906921 0,08450711 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01906921 0,0843446 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01906921 0,08418271 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01906921 0,08402144 ! parturition GO:0007567 12 6 0,000 0,01906921 0,08386079 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01906921 0,08370075 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01906921 0,08354132 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01906921 0,08338249 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01906921 0,08322427 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01906921 0,08306665 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01906921 0,08290962 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01906921 0,08275319 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01906921 0,08259735 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01906921 0,08244209 ! macrophage differentiation GO:0030225 10 6 0,000 0,01906921 0,08228741 ! astrocyte development GO:0014002 14 6 0,000 0,01906921 0,08213332 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01906921 0,0819798 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01906921 0,08182685 ! interaction with symbiont GO:0051702 8 6 0,000 0,01906921 0,08167447 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01906921 0,08152266 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01906921 0,08137141 ! eating behavior GO:0042755 6 6 0,000 0,01906921 0,08122072 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01906921 0,08107059 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01906921 0,08092102 ! response to copper ion GO:0046688 9 6 0,000 0,01906921 0,08077199 ! DNA topological change GO:0006265 8 6 0,000 0,01906921 0,08062351 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01906921 0,08047558 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01906921 0,08032819 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01906921 0,08018134 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01906921 0,08003502 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01906921 0,07988924 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01906921 0,07974398 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01906921 0,07959926 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01906921 0,07945506 ! gas homeostasis GO:0033483 11 6 0,000 0,01906921 0,07931138 ! hair follicle maturation GO:0048820 7 6 0,000 0,01906921 0,07916822 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01906921 0,07902557 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01906921 0,07888344 ! Schwann cell development GO:0014044 14 6 0,000 0,01906921 0,07874182 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01906921 0,0786007 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01906921 0,07846009 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01906921 0,07831998 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01906921 0,07818038 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01906921 0,07804127 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01906921 0,07790265 ! histone ubiquitination GO:0016574 7 6 0,000 0,01906921 0,07776452 ! regulation of meiosis GO:0040020 10 6 0,000 0,01906921 0,07762689 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01906921 0,07748974 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01906921 0,07735307 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01906921 0,07721689 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01906921 0,07708118 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01906921 0,07694595 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01906921 0,07681119 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01906921 0,07667691 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01906921 0,07654309 ! receptor internalization GO:0031623 9 6 0,000 0,01906921 0,07640974 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01906921 0,07627685 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01906921 0,07614443 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01906921 0,07601246 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01906921 0,07588095 ! protein deubiquitination GO:0016579 8 6 0,000 0,01906921 0,0757499 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01906921 0,0756193 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,01906921 0,07548914 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01906921 0,07535944 ! axonal fasciculation GO:0007413 9 6 0,000 0,01906921 0,07523017 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01906921 0,07510135 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01906921 0,07497298 ! midbrain development GO:0030901 6 6 0,000 0,01906921 0,07484504 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01906921 0,07471753 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01906921 0,07459046 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01906921 0,07446382 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01906921 0,07433761 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01906921 0,07421183 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01906921 0,07408647 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01906921 0,07396154 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01906921 0,07383702 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01906921 0,07371293 ! adult feeding behavior GO:0008343 6 6 0,000 0,01906921 0,07358925 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01906921 0,07346598 ! blastocyst growth GO:0001832 15 6 0,000 0,01906921 0,07334313 ! pigment granule transport GO:0051904 12 6 0,000 0,01906921 0,07322069 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01906921 0,07309865 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01906921 0,07297702 ! catecholamine transport GO:0051937 7 6 0,000 0,01906921 0,0728558 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01906921 0,07273498 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01906921 0,07261456 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01906921 0,07249453 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01906921 0,0723749 ! protein prenylation GO:0018342 10 6 0,000 0,01906921 0,07225567 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01906921 0,07213683 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01906921 0,07201838 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01906921 0,07190031 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01906921 0,07178264 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01950704 0,07331077 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,01950704 0,07319118 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,0222125 0,08320644 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,0222125 0,08307115 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,0222125 0,08293629 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,0222125 0,08280187 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,0222125 0,08266789 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,0222125 0,08253434 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,0222125 0,08240122 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,0222125 0,08226853 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,0222125 0,08213626 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,0222125 0,08200442 ! reproductive behavior GO:0019098 12 7 0,000 0,0222125 0,08187301 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,0222125 0,08174201 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,0222125 0,08161143 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,0222125 0,08148127 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,0222125 0,08135152 ! oligopeptide transport GO:0006857 11 7 0,000 0,0222125 0,08122219 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,0222125 0,08109326 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,0222125 0,08096475 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,0222125 0,08083664 ! RNA methylation GO:0001510 11 7 0,000 0,0222125 0,08070894 ! pericardium development GO:0060039 8 7 0,000 0,0222125 0,08058164 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,0222125 0,08045473 ! fibril organization GO:0043206 13 7 0,000 0,0222125 0,08032823 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,0222125 0,08020213 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,0222125 0,08007642 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,0222125 0,07995111 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,0222125 0,07982618 ! lipoprotein transport GO:0042953 9 7 0,000 0,0222125 0,07970165 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,0222125 0,0795775 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,0222125 0,07945374 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,0222125 0,07933037 ! estrogen metabolic process GO:0008210 14 7 0,000 0,0222125 0,07920737 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,0222125 0,07908476 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,0222125 0,07896253 ! chemosensory behavior GO:0007635 9 7 0,000 0,0222125 0,07884067 ! microtubule bundle formation GO:0001578 8 7 0,000 0,0222125 0,07871919 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,0222125 0,07859809 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,0222125 0,07847735 ! leukocyte degranulation GO:0043299 10 7 0,000 0,0222125 0,07835699 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,0222125 0,07823699 ! reflex GO:0060004 12 7 0,000 0,0222125 0,07811736 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,0222125 0,0779981 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,0222125 0,0778792 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,0222125 0,07776066 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,0222125 0,07764249 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,0222125 0,07752467 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,0222125 0,07740721 ! spinal cord patterning GO:0021511 7 7 0,000 0,0222125 0,0772901 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,0222125 0,07717335 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,0222125 0,07705695 ! adrenal gland development GO:0030325 17 7 0,000 0,0222125 0,0769409 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,0222125 0,0768252 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,0222125 0,07670984 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,0222125 0,07659484 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,0222125 0,07648017 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,0222125 0,07636585 ! endosome organization GO:0007032 10 7 0,000 0,0222125 0,07625188 ! thyroid hormone generation GO:0006590 11 7 0,000 0,0222125 0,07613824 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,0222125 0,07602494 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,0222125 0,07591197 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,0222125 0,07579934 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,0222125 0,07568705 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,0222125 0,07557508 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,0222125 0,07546345 ! galactose metabolic process GO:0006012 10 7 0,000 0,0222125 0,07535215 ! vesicle fusion GO:0006906 15 7 0,000 0,0222125 0,07524117 ! intracellular pH reduction GO:0051452 10 7 0,000 0,0222125 0,07513052 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,0222125 0,0750202 ! organ growth GO:0035265 11 7 0,000 0,0222125 0,0749102 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,0222125 0,07480052 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,0222125 0,07469116 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,0222125 0,07458213 ! retinol metabolic process GO:0042572 9 7 0,000 0,0222125 0,07447341 ! behavioral fear response GO:0001662 13 7 0,000 0,0222125 0,074365 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,0222125 0,07425691 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,0222125 0,07414914 ! rRNA modification GO:0000154 12 7 0,000 0,0222125 0,07404168 ! protein heterooligomerization GO:0051291 10 7 0,000 0,0222125 0,07393452 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,0222125 0,07382768 ! response to UV-B GO:0010224 11 7 0,000 0,0222125 0,07372115 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,0222125 0,07361492 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,0222125 0,073509 ! intermediate filament organization GO:0045109 11 7 0,000 0,0222125 0,07340339 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,0222125 0,07329807 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,0222125 0,07319306 ! fibrinolysis GO:0042730 9 7 0,000 0,0222125 0,07308835 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,0222125 0,07298394 ! B cell lineage commitment GO:0002326 17 7 0,000 0,0222125 0,07287982 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,0222125 0,07277601 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,0222125 0,07267248 ! response to tropane GO:0014073 13 7 0,000 0,0222125 0,07256926 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,0222125 0,07246632 ! melanosome localization GO:0032400 10 7 0,000 0,0222125 0,07236368 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,0222125 0,07226132 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,0222125 0,07215926 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,0222125 0,07205748 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,0222125 0,071956 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,0222125 0,07185479 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,0222125 0,07175387 ! mast cell activation GO:0045576 9 7 0,000 0,0222125 0,07165324 ! multicellular organismal aging GO:0010259 11 7 0,000 0,0222125 0,07155288 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,0222125 0,07145281 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,0222125 0,07135301 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,0222125 0,0712535 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,0222125 0,07115426 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,0222125 0,07105529 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,0222125 0,07095661 ! T cell lineage commitment GO:0002360 12 7 0,000 0,0222125 0,07085819 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,0222125 0,07076005 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,0222125 0,07066218 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,0222125 0,07056458 ! regulation of lipid transport GO:0032368 13 7 0,000 0,0222125 0,07046725 ! response to tumor cell GO:0002347 12 7 0,000 0,0222125 0,07037019 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,0222125 0,07027339 ! neuroblast proliferation GO:0007405 13 7 0,000 0,0222125 0,07017686 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,0222125 0,0700806 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,0222125 0,0699846 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,0222125 0,06988886 ! diuresis GO:0030146 12 7 0,000 0,0222125 0,06979338 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,0222125 0,06969817 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,0222125 0,06960321 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,0222125 0,06950851 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,0222125 0,06941407 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,0222125 0,06931989 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,0222125 0,06922596 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,0222125 0,06913228 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,0222125 0,06903886 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,0222125 0,06894569 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,0222125 0,06885277 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,0222125 0,0687601 ! lymph node development GO:0048535 9 7 0,000 0,0222125 0,06866768 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,0222125 0,06857551 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,0222125 0,06848359 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,0222125 0,06839191 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,0222125 0,06830048 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,0222125 0,06820929 ! ATP catabolic process GO:0006200 10 7 0,000 0,0222125 0,06811834 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,0222125 0,06802764 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,0222125 0,06793718 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,0222125 0,06784695 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,0222125 0,06775697 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,0222125 0,06766723 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,0222125 0,06757772 ! muscle adaptation GO:0043500 12 7 0,000 0,0222125 0,06748845 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,0222125 0,06739942 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,0222125 0,06731061 ! retina homeostasis GO:0001895 9 7 0,000 0,0222125 0,06722205 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,0222125 0,06713371 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,0222125 0,06704561 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,0222125 0,06695774 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,0222125 0,0668701 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,0222125 0,06678269 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,0222125 0,0666955 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,0222125 0,06660855 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,02232301 0,06685278 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,02349382 0,07026762 ! negative regulation of growth GO:0045926 123 75 1,000 0,02408857 0,07195287 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,02468948 0,07365215 ! regulation of protein transport GO:0051223 114 76 1,000 0,02468948 0,07355675 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 1,000 0,02529652 0,07526777 ! gland development GO:0048732 148 77 1,000 0,02529652 0,07517053 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,02529652 0,07507353 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0253459 0,07512315 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0253459 0,07502647 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0253459 0,07493004 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0253459 0,07483385 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0253459 0,07473791 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,0253459 0,07464221 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,0253459 0,07454676 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0253459 0,07445156 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0253459 0,07435659 ! phosphate transport GO:0006817 10 8 0,000 0,0253459 0,07426187 ! N-glycan processing GO:0006491 12 8 0,000 0,0253459 0,07416739 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0253459 0,07407315 ! UTP metabolic process GO:0046051 8 8 0,000 0,0253459 0,07397915 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0253459 0,07388538 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0253459 0,07379186 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0253459 0,07369857 ! succinate metabolic process GO:0006105 14 8 0,000 0,0253459 0,07360552 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,0253459 0,0735127 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,0253459 0,07342011 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0253459 0,07332776 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,0253459 0,07323564 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0253459 0,07314375 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,0253459 0,07305209 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0253459 0,07296066 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0253459 0,07286946 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0253459 0,07277849 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0253459 0,07268774 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,0253459 0,07259722 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0253459 0,07250693 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0253459 0,07241685 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0253459 0,07232701 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0253459 0,07223738 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0253459 0,07214798 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0253459 0,0720588 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,0253459 0,07196984 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0253459 0,0718811 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0253459 0,07179257 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0253459 0,07170427 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0253459 0,07161618 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0253459 0,0715283 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0253459 0,07144065 ! melanin metabolic process GO:0006582 12 8 0,000 0,0253459 0,0713532 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0253459 0,07126598 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0253459 0,07117896 ! macrophage activation GO:0042116 12 8 0,000 0,0253459 0,07109216 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0253459 0,07100556 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0253459 0,07091918 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,0253459 0,07083301 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0253459 0,07074705 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0253459 0,07066129 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0253459 0,07057575 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0253459 0,07049041 ! ruffle organization GO:0031529 11 8 0,000 0,0253459 0,07040528 ! osteoblast development GO:0002076 13 8 0,000 0,0253459 0,07032035 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0253459 0,07023562 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0253459 0,0701511 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0253459 0,07006679 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0253459 0,06998267 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,0253459 0,06989876 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0253459 0,06981505 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0253459 0,06973154 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0253459 0,06964823 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0253459 0,06956512 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,0253459 0,0694822 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,0253459 0,06939949 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0253459 0,06931697 ! segment specification GO:0007379 10 8 0,000 0,0253459 0,06923464 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0253459 0,06915251 ! cellular extravasation GO:0045123 11 8 0,000 0,0253459 0,06907058 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0253459 0,06898884 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0253459 0,06890729 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0253459 0,06882594 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0253459 0,06874477 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0253459 0,0686638 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0253459 0,06858302 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0253459 0,06850243 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,0253459 0,06842203 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0253459 0,06834181 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0253459 0,06826179 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0253459 0,06818195 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0253459 0,0681023 ! icosanoid secretion GO:0032309 12 8 0,000 0,0253459 0,06802283 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0253459 0,06794355 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0253459 0,06786446 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0253459 0,06778554 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0253459 0,06770682 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0253459 0,06762827 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0253459 0,06754991 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0253459 0,06747172 ! sterol catabolic process GO:0016127 9 8 0,000 0,0253459 0,06739372 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0253459 0,0673159 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0253459 0,06723826 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0253459 0,06716079 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0253459 0,06708351 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0253459 0,0670064 ! prophase GO:0051324 11 8 0,000 0,0253459 0,06692947 ! S phase GO:0051320 8 8 0,000 0,0253459 0,06685272 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0253459 0,06677614 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0253459 0,06669973 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0253459 0,06662351 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0253459 0,06654745 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0253459 0,06647157 ! hormone catabolic process GO:0042447 13 8 0,000 0,0253459 0,06639586 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0253459 0,06632033 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,0253459 0,06624496 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,0253459 0,06616977 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0253459 0,06609475 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,0253459 0,0660199 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,0253459 0,06594521 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0253459 0,0658707 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0253459 0,06579635 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,0253459 0,06572217 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,0253459 0,06564816 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0253459 0,06557432 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0253459 0,06550064 ! regulation of embryonic development GO:0045995 16 8 0,000 0,0253459 0,06542712 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0253459 0,06535378 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0253459 0,06528059 ! forebrain development GO:0030900 131 80 1,000 0,02715392 0,06985908 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,02778501 0,07140283 GO:0002696|positive regulation of leukocyte activation, ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,02846943 0,07308002 ! regulation of developmental growth GO:0048638 13 9 0,000 0,02846943 0,07299855 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,02846943 0,07291726 ! telencephalon cell migration GO:0022029 16 9 0,000 0,02846943 0,07283615 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,02846943 0,07275522 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02846943 0,07267447 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02846943 0,0725939 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,02846943 0,07251351 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,02846943 0,07243329 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02846943 0,07235326 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02846943 0,07227339 ! GTP metabolic process GO:0046039 9 9 0,000 0,02846943 0,07219371 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02846943 0,0721142 ! social behavior GO:0035176 14 9 0,000 0,02846943 0,07203487 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02846943 0,07195571 ! artery development GO:0060840 19 9 0,000 0,02846943 0,07187672 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,02846943 0,07179791 ! regulation of glycolysis GO:0006110 15 9 0,000 0,02846943 0,07171927 ! response to pain GO:0048265 16 9 0,000 0,02846943 0,07164081 ! protein complex disassembly GO:0043241 17 9 0,000 0,02846943 0,07156251 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,02846943 0,07148438 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02846943 0,07140643 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02846943 0,07132864 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02846943 0,07125103 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02846943 0,07117358 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02846943 0,0710963 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02846943 0,07101919 ! protein targeting to ER GO:0045047 19 9 0,000 0,02846943 0,07094225 ! T cell selection GO:0045058 18 9 0,000 0,02846943 0,07086547 ! endoderm development GO:0007492 12 9 0,000 0,02846943 0,07078886 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02846943 0,07071241 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02846943 0,07063613 ! arginine catabolic process GO:0006527 10 9 0,000 0,02846943 0,07056002 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02846943 0,07048406 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02846943 0,07040828 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02846943 0,07033265 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02846943 0,07025718 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02846943 0,07018188 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02846943 0,07010674 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02846943 0,07003176 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02846943 0,06995694 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02846943 0,06988228 ! mannose metabolic process GO:0006013 9 9 0,000 0,02846943 0,06980778 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02846943 0,06973344 ! receptor clustering GO:0043113 15 9 0,000 0,02846943 0,06965925 ! epithelial cell development GO:0002064 10 9 0,000 0,02846943 0,06958522 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02846943 0,06951135 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02846943 0,06943764 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02846943 0,06936408 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02846943 0,06929068 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02846943 0,06921744 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02846943 0,06914435 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02846943 0,06907141 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02846943 0,06899863 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02846943 0,068926 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02846943 0,06885352 ! DNA ligation GO:0006266 14 9 0,000 0,02846943 0,06878119 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02846943 0,06870902 ! response to amine stimulus GO:0014075 13 9 0,000 0,02846943 0,068637 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02846943 0,06856513 ! erythrocyte development GO:0048821 11 9 0,000 0,02846943 0,06849341 ! renal water homeostasis GO:0003091 14 9 0,000 0,02846943 0,06842183 ! postreplication repair GO:0006301 11 9 0,000 0,02846943 0,06835041 ! mRNA cleavage GO:0006379 13 9 0,000 0,02846943 0,06827914 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02846943 0,06820802 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02846943 0,06813704 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02846943 0,06806621 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02846943 0,06799553 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02846943 0,067925 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02846943 0,06785461 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02846943 0,06778436 ! acid secretion GO:0046717 14 9 0,000 0,02846943 0,06771427 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02846943 0,06764431 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02846943 0,06757451 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02846943 0,06750484 ! purine base metabolic process GO:0006144 18 9 0,000 0,02846943 0,06743532 ! oocyte differentiation GO:0009994 12 9 0,000 0,02846943 0,06736594 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02846943 0,06729671 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02846943 0,06722761 ! spleen development GO:0048536 15 9 0,000 0,02846943 0,06715866 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02846943 0,06708985 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02846943 0,06702118 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02846943 0,06695265 ! detection of calcium ion GO:0005513 13 9 0,000 0,02846943 0,06688427 ! blastocyst formation GO:0001825 12 9 0,000 0,02846943 0,06681602 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02846943 0,06674791 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02846943 0,06667993 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02846943 0,0666121 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02846943 0,06654441 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02846943 0,06647685 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02846943 0,06640943 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02846943 0,06634214 ! prepulse inhibition GO:0060134 14 9 0,000 0,02846943 0,066275 ! embryonic placenta development GO:0001892 12 9 0,000 0,02846943 0,06620798 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,02846943 0,06614111 ! insulin secretion GO:0030073 17 9 0,000 0,02846943 0,06607437 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02846943 0,06600776 ! response to nicotine GO:0035094 16 9 0,000 0,02846943 0,06594128 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02846943 0,06587495 ! nucleus localization GO:0051647 15 9 0,000 0,02846943 0,06580874 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02846943 0,06574267 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,02906487 0,06705035 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,030368 0,06998638 ! regulation of protein localization GO:0032880 132 85 1,000 0,030368 0,06991633 ! regulation of membrane potential GO:0042391 128 85 1,000 0,030368 0,06984641 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,030368 0,06977663 ! cell cycle arrest GO:0007050 150 86 1,000 0,0310282 0,07122241 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,03158313 0,07242394 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,03158313 0,0723518 ! neuron fate specification GO:0048665 11 10 0,000 0,03158313 0,07227981 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,03158313 0,07220796 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,03158313 0,07213626 ! thyroid gland development GO:0030878 19 10 0,000 0,03158313 0,07206469 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,03158313 0,07199327 ! synapsis GO:0007129 13 10 0,000 0,03158313 0,07192199 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,03158313 0,07185085 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,03158313 0,07177985 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,03158313 0,07170899 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,03158313 0,07163827 ! sulfate transport GO:0008272 12 10 0,000 0,03158313 0,07156769 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,03158313 0,07149725 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,03158313 0,07142695 ! androgen metabolic process GO:0008209 13 10 0,000 0,03158313 0,07135679 ! phospholipid efflux GO:0033700 16 10 0,000 0,03158313 0,07128676 ! hippocampus development GO:0021766 19 10 0,000 0,03158313 0,07121687 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,03158313 0,07114712 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,03158313 0,0710775 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,03158313 0,07100803 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,03158313 0,07093868 ! pathogenesis GO:0009405 13 10 0,000 0,03158313 0,07086947 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,03158313 0,0708004 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03158313 0,07073146 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,03158313 0,07066266 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,03158313 0,07059398 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,03158313 0,07052545 ! melanocyte differentiation GO:0030318 15 10 0,000 0,03158313 0,07045704 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,03158313 0,07038877 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,03158313 0,07032063 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03158313 0,07025262 ! response to X-ray GO:0010165 16 10 0,000 0,03158313 0,07018474 ! B cell proliferation GO:0042100 14 10 0,000 0,03158313 0,070117 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,03158313 0,07004938 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,03158313 0,0699819 ! forebrain cell migration GO:0021885 17 10 0,000 0,03158313 0,06991454 ! lipid digestion GO:0044241 15 10 0,000 0,03158313 0,06984732 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,03158313 0,06978022 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,03158313 0,06971325 ! UV protection GO:0009650 14 10 0,000 0,03158313 0,06964641 ! entry into host cell GO:0030260 20 10 0,000 0,03158313 0,0695797 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,03158313 0,06951312 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,03158313 0,06944666 ! negative regulation of ossification GO:0030279 19 10 0,000 0,03158313 0,06938033 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,03158313 0,06931413 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,03158313 0,06924806 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,03158313 0,0691821 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,03158313 0,06911628 ! regulation of organ growth GO:0046620 11 10 0,000 0,03158313 0,06905058 ! response to dsRNA GO:0043331 18 10 0,000 0,03158313 0,068985 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,03158313 0,06891955 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03158313 0,06885423 ! embryonic axis specification GO:0000578 12 10 0,000 0,03158313 0,06878902 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,03158313 0,06872395 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,03158313 0,06865899 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,03158313 0,06859415 ! cranial nerve development GO:0021545 12 10 0,000 0,03158313 0,06852944 ! fucose catabolic process GO:0019317 16 10 0,000 0,03158313 0,06846485 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,03158313 0,06840039 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,03158313 0,06833604 ! protein sumoylation GO:0016925 12 10 0,000 0,03158313 0,06827181 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,03158313 0,06820771 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03158313 0,06814372 ! zymogen activation GO:0031638 14 10 0,000 0,03158313 0,06807986 ! salivary gland development GO:0007431 22 10 0,000 0,03158313 0,06801611 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03158313 0,06795249 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,03158313 0,06788898 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,03158313 0,06782559 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,03158313 0,06776232 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,03158313 0,06769917 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03158313 0,06763614 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,03158313 0,06757322 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,03158313 0,06751042 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,03158313 0,06744773 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,03158313 0,06738517 ! detection of bacterium GO:0016045 10 10 0,000 0,03158313 0,06732272 ! embryonic gut development GO:0048566 11 10 0,000 0,03158313 0,06726038 ! activation of innate immune response GO:0002218 10 10 0,000 0,03158313 0,06719816 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,03158313 0,06713605 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,03158313 0,06707406 ! developmental induction GO:0031128 13 10 0,000 0,03158313 0,06701219 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,03158313 0,06695042 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,03158313 0,06688878 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,03158313 0,06682724 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,03158313 0,06676582 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,03304277 0,0697873 ! regulation of T cell activation GO:0050863 128 89 1,000 0,03304277 0,06972327 ! rRNA transcription GO:0009303 17 11 0,000 0,03468703 0,07312574 ! respiratory burst GO:0045730 14 11 0,000 0,03468703 0,07305877 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,03468703 0,07299193 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,03468703 0,07292521 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,03468703 0,07285861 ! virus-host interaction GO:0019048 17 11 0,000 0,03468703 0,07279214 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,03468703 0,07272578 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,03468703 0,07265955 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,03468703 0,07259343 ! RNA polyadenylation GO:0043631 19 11 0,000 0,03468703 0,07252744 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,03468703 0,07246156 ! mating GO:0007618 14 11 0,000 0,03468703 0,07239581 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,03468703 0,07233017 ! T cell proliferation GO:0042098 20 11 0,000 0,03468703 0,07226466 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,03468703 0,07219926 ! bone resorption GO:0045453 16 11 0,000 0,03468703 0,07213398 ! regulated secretory pathway GO:0045055 14 11 0,000 0,03468703 0,07206882 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,03468703 0,07200377 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,03468703 0,07193885 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,03468703 0,07187404 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,03468703 0,07180934 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,03468703 0,07174477 ! syncytium formation GO:0006949 15 11 0,000 0,03468703 0,07168031 ! plasma membrane organization GO:0007009 18 11 0,000 0,03468703 0,07161596 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,03468703 0,07155173 ! focal adhesion formation GO:0048041 24 11 0,000 0,03468703 0,07148762 ! mitotic spindle organization GO:0007052 15 11 0,000 0,03468703 0,07142362 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,03468703 0,07135973 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,03468703 0,07129596 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,03468703 0,0712323 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,03468703 0,07116876 ! adult heart development GO:0007512 11 11 0,000 0,03468703 0,07110533 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,03468703 0,07104201 ! temperature homeostasis GO:0001659 16 11 0,000 0,03468703 0,07097881 ! L-glutamate transport GO:0015813 16 11 0,000 0,03468703 0,07091572 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,03468703 0,07085274 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,03468703 0,07078987 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,03468703 0,07072711 ! stem cell development GO:0048864 29 11 0,000 0,03468703 0,07066446 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,03468703 0,07060193 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,03468703 0,07053951 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,03468703 0,07047719 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,03468703 0,07041499 ! vasoconstriction GO:0042310 15 11 0,000 0,03468703 0,07035289 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,03468703 0,07029091 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,03468703 0,07022903 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,03468703 0,07016727 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,03468703 0,07010561 ! ribosome assembly GO:0042255 13 11 0,000 0,03468703 0,07004406 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,03468703 0,06998261 GO:0006809|nitric oxide biosynthetic process, ! chromatin silencing GO:0006342 19 11 0,000 0,03468703 0,06992128 ! nucleosome positioning GO:0016584 13 11 0,000 0,03468703 0,06986005 ! T cell homeostasis GO:0043029 20 11 0,000 0,03468703 0,06979893 ! regulation of isotype switching GO:0045191 19 11 0,000 0,03468703 0,06973792 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,03468703 0,06967701 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,03468703 0,06961621 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,03468703 0,06955552 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,03468703 0,06949493 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,03468703 0,06943445 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,03468703 0,06937407 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,03468703 0,0693138 ! male genitalia development GO:0030539 13 11 0,000 0,03468703 0,06925363 ! cholesterol efflux GO:0033344 19 11 0,000 0,03468703 0,06919357 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,03468703 0,06913361 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,03468703 0,06907375 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,03468703 0,069014 ! germ cell migration GO:0008354 18 11 0,000 0,03468703 0,06895435 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,03468703 0,0688948 ! defense response to fungus GO:0050832 12 11 0,000 0,03468703 0,06883536 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,03468703 0,06877602 ! lysogeny GO:0030069 18 11 0,000 0,03468703 0,06871678 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,03468703 0,06865764 ! acrosome reaction GO:0007340 13 11 0,000 0,03468703 0,06859861 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,03468703 0,06853967 ! cell fate commitment GO:0045165 141 92 1,000 0,03510746 0,06931086 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,03580664 0,07063058 ! regulation of binding GO:0051098 151 95 1,000 0,03722116 0,0733579 ! lactation GO:0007595 20 12 0,000 0,03778116 0,07439784 ! reproductive cellular process GO:0048610 14 12 0,000 0,03778116 0,0743342 ! tRNA modification GO:0006400 14 12 0,000 0,03778116 0,07427066 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,03778116 0,07420724 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,03778116 0,07414392 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,03778116 0,07408071 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,03778116 0,07401761 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,03778116 0,07395462 ! non-recombinational repair GO:0000726 19 12 0,000 0,03778116 0,07389173 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,03778116 0,07382895 ! peroxisomal transport GO:0043574 21 12 0,000 0,03778116 0,07376628 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,03778116 0,07370371 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,03778116 0,07364125 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,03778116 0,0735789 ! heart looping GO:0001947 15 12 0,000 0,03778116 0,07351665 ! palate development GO:0060021 15 12 0,000 0,03778116 0,0734545 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,03778116 0,07339246 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,03778116 0,07333053 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,03778116 0,0732687 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,03778116 0,07320697 ! arginine metabolic process GO:0006525 13 12 0,000 0,03778116 0,07314535 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,03778116 0,07308383 ! methionine metabolic process GO:0006555 13 12 0,000 0,03778116 0,07302242 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,03778116 0,07296111 ! Golgi organization GO:0007030 18 12 0,000 0,03778116 0,0728999 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,03778116 0,07283879 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,03778116 0,07277779 ! monoamine transport GO:0015844 13 12 0,000 0,03778116 0,07271688 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03778116 0,07265608 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,03778116 0,07259539 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,03778116 0,07253479 ! L-amino acid transport GO:0015807 20 12 0,000 0,03778116 0,07247429 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,03778116 0,0724139 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,03778116 0,0723536 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,03778116 0,07229341 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03778116 0,07223331 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,03778116 0,07217332 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,03778116 0,07211342 ! cerebellum development GO:0021549 13 12 0,000 0,03778116 0,07205363 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,03778116 0,07199393 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,03778116 0,07193434 ! histone methylation GO:0016571 15 12 0,000 0,03778116 0,07187484 ! autonomic nervous system development GO:0048483 23 12 0,000 0,03778116 0,07181544 ! gland morphogenesis GO:0022612 23 12 0,000 0,03778116 0,07175613 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,03778116 0,07169693 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,03778116 0,07163782 ! response to gamma radiation GO:0010332 20 12 0,000 0,03778116 0,07157881 ! regulation of epidermis development GO:0045682 17 12 0,000 0,03778116 0,0715199 ! intestinal absorption GO:0050892 19 12 0,000 0,03778116 0,07146108 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,03778116 0,07140236 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,03778116 0,07134374 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,03778116 0,07128521 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,03778116 0,07122678 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,03778116 0,07116845 ! microspike assembly GO:0030035 23 12 0,000 0,03778116 0,07111021 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,03778116 0,07105207 ! response to cold GO:0009409 14 12 0,000 0,03778116 0,07099402 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,03793643 0,07122758 ! extracellular structure organization GO:0043062 156 99 1,000 0,04011378 0,07525424 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,04086555 0,07660209 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,04086555 0,07653971 ! cGMP metabolic process GO:0046068 16 13 0,000 0,04086555 0,07647744 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,04086555 0,07641526 ! water transport GO:0006833 17 13 0,000 0,04086555 0,07635318 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,04086555 0,07629121 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,04086555 0,07622933 ! lipid localization GO:0010876 24 13 0,000 0,04086555 0,07616756 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,04086555 0,07610589 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,04086555 0,07604431 ! organelle fusion GO:0048284 28 13 0,000 0,04086555 0,07598284 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,04086555 0,07592146 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,04086555 0,07586018 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,04086555 0,07579901 ! response to hexose stimulus GO:0009746 19 13 0,000 0,04086555 0,07573793 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,04086555 0,07567695 ! glutamate metabolic process GO:0006536 18 13 0,000 0,04086555 0,07561607 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,04086555 0,07555528 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,04086555 0,07549459 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,04086555 0,075434 ! NAD metabolic process GO:0019674 21 13 0,000 0,04086555 0,07537351 ! exocrine system development GO:0035272 27 13 0,000 0,04086555 0,07531312 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,04086555 0,07525282 ! bone mineralization GO:0030282 15 13 0,000 0,04086555 0,07519262 ! regulation of exocytosis GO:0017157 17 13 0,000 0,04086555 0,07513251 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,04086555 0,0750725 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,04086555 0,07501258 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,04086555 0,07495277 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,04086555 0,07489304 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,04086555 0,07483341 ! genitalia development GO:0048806 15 13 0,000 0,04086555 0,07477388 ! regulation of cellular pH GO:0030641 20 13 0,000 0,04086555 0,07471444 ! cellular pigmentation GO:0033059 24 13 0,000 0,04086555 0,0746551 ! tissue regeneration GO:0042246 21 13 0,000 0,04086555 0,07459585 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,04086555 0,07453669 ! cofactor transport GO:0051181 19 13 0,000 0,04086555 0,07447763 ! NADP metabolic process GO:0006739 18 13 0,000 0,04086555 0,07441866 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,04086555 0,07435979 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,04086555 0,074301 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,04086555 0,07424231 ! gas transport GO:0015669 18 13 0,000 0,04086555 0,07418372 ! heme biosynthetic process GO:0006783 20 13 0,000 0,04086555 0,07412521 ! regulation of axon extension GO:0030516 23 13 0,000 0,04086555 0,0740668 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,04086555 0,07400848 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,04086555 0,07395025 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,04086555 0,07389211 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,04086555 0,07383407 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,04086555 0,07377611 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,04086555 0,07371825 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,04394023 0,07920261 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,04394023 0,07914058 ! superoxide anion generation GO:0042554 18 14 0,000 0,04394023 0,07907866 ! neuron maturation GO:0042551 21 14 0,000 0,04394023 0,07901683 ! regulation of S phase GO:0033261 18 14 0,000 0,04394023 0,0789551 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,04394023 0,07889346 ! myotube differentiation GO:0014902 21 14 0,000 0,04394023 0,07883192 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,04394023 0,07877048 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,04394023 0,07870913 ! inositol metabolic process GO:0006020 20 14 0,000 0,04394023 0,07864788 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,04394023 0,07858672 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,04394023 0,07852566 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,04394023 0,07846469 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,04394023 0,07840382 ! gene silencing by RNA GO:0031047 20 14 0,000 0,04394023 0,07834304 ! response to cAMP GO:0051591 19 14 0,000 0,04394023 0,07828236 ! limbic system development GO:0021761 25 14 0,000 0,04394023 0,07822177 ! startle response GO:0001964 21 14 0,000 0,04394023 0,07816127 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,04394023 0,07810087 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,04394023 0,07804056 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,04394023 0,07798034 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,04394023 0,07792022 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,04394023 0,07786019 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,04394023 0,07780025 ! glycine metabolic process GO:0006544 22 14 0,000 0,04394023 0,0777404 ! pituitary gland development GO:0021983 23 14 0,000 0,04394023 0,07768065 ! cellular response to starvation GO:0009267 21 14 0,000 0,04394023 0,07762099 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,04394023 0,07756142 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,04394023 0,07750194 ! regulation of heart rate GO:0002027 23 14 0,000 0,04394023 0,07744255 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,04394023 0,07738325 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,04394023 0,07732404 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,04394023 0,07726493 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,04394023 0,0772059 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,04394023 0,07714697 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,04394023 0,07708812 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,04394023 0,07702936 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,04394023 0,0769707 ! axon cargo transport GO:0008088 27 14 0,000 0,04394023 0,07691212 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,04394023 0,07685363 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,04394023 0,07679523 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,04394023 0,07673692 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,04394023 0,0766787 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,04394023 0,07662057 ! mRNA splice site selection GO:0006376 26 14 0,000 0,04394023 0,07656252 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,04394023 0,07650456 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,04394023 0,07644669 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,04394023 0,07638891 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,04394023 0,07633121 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,04394023 0,0762736 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,04394023 0,07621608 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,04394023 0,07615865 ! muscle maintenance GO:0046716 19 14 0,000 0,04394023 0,0761013 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,04394023 0,07604404 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,04394023 0,07598686 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,04394023 0,07592977 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,04394023 0,07587277 ! cell killing GO:0001906 20 14 0,000 0,04394023 0,07581585 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,04394023 0,07575901 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,04394023 0,07570227 ! cilium assembly GO:0042384 20 14 0,000 0,04394023 0,0756456 ! peptide hormone secretion GO:0030072 23 14 0,000 0,04394023 0,07558902 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,04700522 0,08080121 ! positive regulation of cell size GO:0045793 20 15 0,000 0,04700522 0,08074086 ! metencephalon development GO:0022037 19 15 0,000 0,04700522 0,08068061 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,04700522 0,08062044 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,04700522 0,08056037 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,04700522 0,08050038 ! skin development GO:0043588 25 15 0,000 0,04700522 0,08044049 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,04700522 0,08038068 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,04700522 0,08032096 ! lipid phosphorylation GO:0046834 23 15 0,000 0,04700522 0,08026133 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,04700522 0,08020179 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,04700522 0,08014234 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,04700522 0,08008297 ! bile acid metabolic process GO:0008206 22 15 0,000 0,04700522 0,0800237 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,04700522 0,07996451 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,04700522 0,07990541 ! adult walking behavior GO:0007628 25 15 0,000 0,04700522 0,07984639 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,04700522 0,07978747 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,04700522 0,07972863 ! myoblast differentiation GO:0045445 27 15 0,000 0,04700522 0,07966987 ! centrosome cycle GO:0007098 16 15 0,000 0,04700522 0,0796112 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,04700522 0,07955262 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,04700522 0,07949413 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,04700522 0,07943572 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,04700522 0,0793774 ! cerebral cortex development GO:0021987 29 15 0,000 0,04700522 0,07931916 ! response to osmotic stress GO:0006970 22 15 0,000 0,04700522 0,07926101 ! vesicle coating GO:0006901 25 15 0,000 0,04700522 0,07920294 ! DNA integration GO:0015074 22 15 0,000 0,04700522 0,07914496 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,04700522 0,07908706 ! peptide secretion GO:0002790 27 15 0,000 0,04700522 0,07902925 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,04700522 0,07897152 ! regulation of vasodilation GO:0042312 24 15 0,000 0,04700522 0,07891388 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,04700522 0,07885632 ! neuron recognition GO:0008038 22 15 0,000 0,04700522 0,07879885 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,04700522 0,07874145 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,04700522 0,07868415 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,04700522 0,07862692 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,04700522 0,07856978 ! biomineral formation GO:0031214 18 15 0,000 0,04700522 0,07851272 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,04700522 0,07845574 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,04700522 0,07839885 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,04700522 0,07834204 ! dopamine metabolic process GO:0042417 30 15 0,000 0,04700522 0,07828531 ! organic cation transport GO:0015695 19 15 0,000 0,04700522 0,07822867 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,04700522 0,0781721 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,04700522 0,07811562 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,04700522 0,07805922 ! defense response to virus GO:0051607 27 15 0,000 0,04700522 0,0780029 ! peptide hormone processing GO:0016486 19 15 0,000 0,04700522 0,07794666 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,04700522 0,0778905 ! protein secretion GO:0009306 27 16 0,000 0,05006057 0,08289367 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,05006057 0,08283404 ! hormone secretion GO:0046879 25 16 0,000 0,05006057 0,08277449 ! bone remodeling GO:0046849 24 16 0,000 0,05006057 0,08271502 ! endothelial cell migration GO:0043542 22 16 0,000 0,05006057 0,08265564 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05006057 0,08259635 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,05006057 0,08253714 ! glial cell development GO:0021782 24 16 0,000 0,05006057 0,08247802 ! patterning of blood vessels GO:0001569 24 16 0,000 0,05006057 0,08241898 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,05006057 0,08236002 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,05006057 0,08230115 ! protein polyubiquitination GO:0000209 26 16 0,000 0,05006057 0,08224236 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,05006057 0,08218366 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,05006057 0,08212504 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,05006057 0,08206651 ! fructose metabolic process GO:0006000 20 16 0,000 0,05006057 0,08200805 ! regulation of protein binding GO:0043393 27 16 0,000 0,05006057 0,08194969 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,05006057 0,0818914 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,05006057 0,0818332 ! protein export from nucleus GO:0006611 24 16 0,000 0,05006057 0,08177508 ! negative regulation of immune response GO:0050777 28 16 0,000 0,05006057 0,08171704 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,05006057 0,08165908 ! DNA replication initiation GO:0006270 25 16 0,000 0,05006057 0,08160121 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,05006057 0,08154342 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,05006057 0,08148571 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,05006057 0,08142808 ! diencephalon development GO:0021536 25 16 0,000 0,05006057 0,08137054 ! oogenesis GO:0048477 23 16 0,000 0,05006057 0,08131307 ! G1 phase GO:0051318 27 16 0,000 0,05006057 0,08125569 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,05006057 0,08119838 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,05006057 0,08114116 ! steroid catabolic process GO:0006706 22 16 0,000 0,05006057 0,08108402 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,05006057 0,08102696 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,05006057 0,08096998 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,05006057 0,08091308 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,05006057 0,08085626 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,05006057 0,08079952 ! sperm-egg recognition GO:0035036 16 16 0,000 0,05006057 0,08074285 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,05006057 0,08068627 ! nerve development GO:0021675 18 16 0,000 0,05006057 0,08062977 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,05006057 0,08057334 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,05006057 0,080517 ! negative regulation of translation GO:0017148 22 16 0,000 0,05006057 0,08046073 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,05310629 0,08529642 ! negative regulation of defense response GO:0031348 19 17 0,000 0,05310629 0,0852369 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,05310629 0,08517746 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,05310629 0,0851181 ! glycerol metabolic process GO:0006071 20 17 0,000 0,05310629 0,08505883 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,05310629 0,08499963 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,05310629 0,08494052 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,05310629 0,0848815 ! signal complex assembly GO:0007172 29 17 0,000 0,05310629 0,08482255 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,05310629 0,08476369 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,05310629 0,08470491 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,05310629 0,0846462 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,05310629 0,08458759 ! memory GO:0007613 25 17 0,000 0,05310629 0,08452905 ! keratinization GO:0031424 17 17 0,000 0,05310629 0,08447059 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,05310629 0,08441221 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,05310629 0,08435392 ! retinoid metabolic process GO:0001523 22 17 0,000 0,05310629 0,0842957 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,05310629 0,08423757 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,05310629 0,08417951 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,05310629 0,08412154 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,05310629 0,08406364 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,05310629 0,08400583 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,05310629 0,08394809 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,05310629 0,08389043 ! membrane budding GO:0006900 29 17 0,000 0,05310629 0,08383286 ! heme metabolic process GO:0042168 27 17 0,000 0,05310629 0,08377536 ! actin filament bundle formation GO:0051017 26 17 0,000 0,05310629 0,08371794 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,05310629 0,0836606 ! body fluid secretion GO:0007589 27 17 0,000 0,05310629 0,08360334 ! stem cell differentiation GO:0048863 36 17 0,000 0,05310629 0,08354615 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,05310629 0,08348905 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,05310629 0,08343202 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,05310629 0,08337507 ! sensory perception of pain GO:0019233 23 17 0,000 0,05310629 0,08331819 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,05310629 0,0832614 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,05310629 0,08320468 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,05310629 0,08314804 ! synaptogenesis GO:0007416 24 17 0,000 0,05310629 0,08309148 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,05310629 0,08303499 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,05310629 0,08297858 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,05310629 0,08292225 ! cell-cell junction organization GO:0045216 25 17 0,000 0,05310629 0,08286599 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,05310629 0,08280981 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,05310629 0,08275371 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,05310629 0,08269768 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,05310629 0,08264173 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,05310629 0,08258585 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,05614242 0,08724836 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,05614242 0,08718945 ! positive regulation of translation GO:0045727 28 18 0,000 0,05614242 0,08713062 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,05614242 0,08707187 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,05614242 0,08701319 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,05614242 0,0869546 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,05614242 0,08689608 ! cAMP metabolic process GO:0046058 33 18 0,000 0,05614242 0,08683764 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,05614242 0,08677929 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,05614242 0,08672101 ! axis specification GO:0009798 26 18 0,000 0,05614242 0,0866628 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,05614242 0,08660468 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,05614242 0,08654663 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,05614242 0,08648867 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,05614242 0,08643077 ! glutamine metabolic process GO:0006541 23 18 0,000 0,05614242 0,08637296 ! response to retinoic acid GO:0032526 25 18 0,000 0,05614242 0,08631523 ! pigmentation during development GO:0048066 31 18 0,000 0,05614242 0,08625757 ! central nervous system neuron development GO:0021954 30 18 0,000 0,05614242 0,08619998 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,05614242 0,08614248 ! fucose metabolic process GO:0006004 26 18 0,000 0,05614242 0,08608505 ! response to fungus GO:0009620 19 18 0,000 0,05614242 0,0860277 ! peptide cross-linking GO:0018149 31 18 0,000 0,05614242 0,08597042 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,05614242 0,08591322 ! heart process GO:0003015 27 18 0,000 0,05614242 0,0858561 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,05614242 0,08579905 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,05614242 0,08574208 ! visual learning GO:0008542 35 18 0,000 0,05614242 0,08568519 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,05614242 0,08562837 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,05614242 0,08557162 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,05614242 0,08551495 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,05614242 0,08545836 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,05614242 0,08540184 ! vitamin transport GO:0051180 24 18 0,000 0,05614242 0,08534539 ! hormone transport GO:0009914 27 18 0,000 0,05614242 0,08528902 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,05614242 0,08523272 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,05614242 0,0851765 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,05614242 0,08512035 ! cell-cell recognition GO:0009988 20 18 0,000 0,05614242 0,08506428 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,05614242 0,08500828 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,05614242 0,08495235 ! gut development GO:0048565 26 18 0,000 0,05614242 0,0848965 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,05614242 0,08484072 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,05614242 0,08478501 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,059169 0,08929704 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,059169 0,08923848 ! positive regulation of ossification GO:0045778 30 19 0,000 0,059169 0,08918001 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,059169 0,0891216 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,059169 0,08906328 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,059169 0,08900503 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,059169 0,08894686 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,059169 0,08888876 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,059169 0,08883074 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,059169 0,08877279 ! regeneration GO:0031099 32 19 0,000 0,059169 0,08871492 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,059169 0,08865713 ! response to alkaloid GO:0043279 32 19 0,000 0,059169 0,08859941 ! sensory perception of taste GO:0050909 23 19 0,000 0,059169 0,08854176 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,059169 0,08848419 ! smooth muscle contraction GO:0006939 36 19 0,000 0,059169 0,0884267 ! peroxisome organization GO:0007031 29 19 0,000 0,059169 0,08836928 ! digestive system process GO:0022600 30 19 0,000 0,059169 0,08831193 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,059169 0,08825466 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,059169 0,08819747 ! response to vitamin A GO:0033189 26 19 0,000 0,059169 0,08814034 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,059169 0,08808329 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,059169 0,08802632 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,059169 0,08796942 ! response to starvation GO:0042594 30 19 0,000 0,059169 0,08791259 ! sex determination GO:0007530 29 19 0,000 0,059169 0,08785584 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,059169 0,08779915 ! plasma membrane fusion GO:0045026 23 19 0,000 0,059169 0,08774255 ! cytolysis GO:0019835 20 19 0,000 0,059169 0,08768601 ! renal system process GO:0003014 35 19 0,000 0,059169 0,08762955 ! vasodilation GO:0042311 33 19 0,000 0,059169 0,08757316 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,059169 0,08751684 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,059169 0,0874606 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,059169 0,08740442 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,059169 0,08734832 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,059169 0,0872923 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,059169 0,08723634 ! sarcomere organization GO:0045214 23 19 0,000 0,059169 0,08718045 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,059169 0,08712464 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,059169 0,0870689 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,059169 0,08701323 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,059169 0,08695763 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,059169 0,0869021 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,059169 0,08684664 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,059169 0,08679126 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,059169 0,08673594 ! protein stabilization GO:0050821 26 19 0,000 0,059169 0,08668069 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,06218603 0,09104257 ! iron ion transport GO:0006826 37 20 0,000 0,06218603 0,09098465 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,06218603 0,09092681 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,06218603 0,09086904 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,06218603 0,09081135 ! response to vitamin GO:0033273 29 20 0,000 0,06218603 0,09075373 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,06218603 0,09069618 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,06218603 0,0906387 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,06218603 0,0905813 ! response to ethanol GO:0045471 37 20 0,000 0,06218603 0,09052397 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,06218603 0,09046672 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,06218603 0,09040953 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,06218603 0,09035242 ! chromosome condensation GO:0030261 31 20 0,000 0,06218603 0,09029538 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,06218603 0,09023841 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,06218603 0,09018151 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,06218603 0,09012469 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,06218603 0,09006793 ! pallium development GO:0021543 38 20 0,000 0,06218603 0,09001125 ! DNA modification GO:0006304 28 20 0,000 0,06218603 0,08995464 ! collagen fibril organization GO:0030199 45 20 0,000 0,06218603 0,0898981 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,06218603 0,08984163 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,06218603 0,08978523 ! collagen catabolic process GO:0030574 25 20 0,000 0,06218603 0,08972891 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,06218603 0,08967265 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,06218603 0,08961646 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,06218603 0,08956035 ! alditol metabolic process GO:0019400 24 20 0,000 0,06218603 0,0895043 ! actin filament-based movement GO:0030048 34 20 0,000 0,06218603 0,08944833 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,06519357 0,09371575 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,06519357 0,09365722 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,06519357 0,09359876 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,06519357 0,09354037 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,06519357 0,09348205 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,06519357 0,09342381 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,06519357 0,09336563 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,06519357 0,09330753 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,06519357 0,09324951 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,06519357 0,09319155 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,06519357 0,09313367 ! phototransduction GO:0007602 25 21 0,000 0,06519357 0,09307586 ! dendrite development GO:0016358 35 21 0,000 0,06519357 0,09301812 ! visual behavior GO:0007632 39 21 0,000 0,06519357 0,09296045 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,06519357 0,09290285 ! ovarian follicle development GO:0001541 30 21 0,000 0,06519357 0,09284533 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,06519357 0,09278788 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,06519357 0,09273049 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,06519357 0,09267318 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,06519357 0,09261594 ! cell aging GO:0007569 32 21 0,000 0,06519357 0,09255877 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,06519357 0,09250167 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,06519357 0,09244464 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,06519357 0,09238768 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,06519357 0,09233079 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,06519357 0,09227397 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,06519357 0,09221722 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,06519357 0,09216055 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,06519357 0,09210394 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,06519357 0,0920474 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,06519357 0,09199093 ! fatty acid transport GO:0015908 30 21 0,000 0,06519357 0,09193452 ! immunoglobulin production GO:0002377 33 21 0,000 0,06519357 0,09187819 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,06519357 0,09182193 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,06519357 0,09176573 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,06519357 0,09170961 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,06519357 0,09165355 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,06519357 0,09159756 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,06519357 0,09154164 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,06519357 0,09148579 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,06519357 0,09143 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,06519357 0,09137429 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,06519357 0,09131864 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,06519357 0,09126306 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,06519357 0,09120755 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,06519357 0,0911521 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,06519357 0,09109672 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,06819163 0,09522814 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,06819163 0,09517036 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,06819163 0,09511264 ! viral genome replication GO:0019079 29 22 0,000 0,06819163 0,095055 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,06819163 0,09499743 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,06819163 0,09493992 ! leukocyte adhesion GO:0007159 38 22 0,000 0,06819163 0,09488249 ! molting cycle process GO:0022404 40 22 0,000 0,06819163 0,09482512 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,06819163 0,09476782 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,06819163 0,0947106 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,06819163 0,09465344 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,06819163 0,09459635 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,06819163 0,09453933 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,06819163 0,09448238 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,06819163 0,0944255 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,06819163 0,09436868 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,06819163 0,09431194 ! lysosome organization GO:0007040 37 22 0,000 0,06819163 0,09425526 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,06819163 0,09419865 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,06819163 0,09414211 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,06819163 0,09408563 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,06819163 0,09402923 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,06819163 0,09397289 ! membrane depolarization GO:0051899 35 22 0,000 0,06819163 0,09391662 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,06819163 0,09386041 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,06819163 0,09380428 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,06819163 0,09374821 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,06819163 0,0936922 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,06819163 0,09363627 ! blastocyst development GO:0001824 37 22 0,000 0,06819163 0,0935804 ! neural tube closure GO:0001843 33 22 0,000 0,06819163 0,0935246 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,06819163 0,09346886 ! protein tetramerization GO:0051262 39 22 0,000 0,06819163 0,09341319 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,07118025 0,09744915 ! embryonic pattern specification GO:0009880 31 23 0,000 0,07118025 0,09739118 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,07118025 0,09733328 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,07118025 0,09727544 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 0,000 0,07118025 0,09721768 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,07118025 0,09715998 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,07118025 0,09710236 ! vesicle targeting GO:0006903 32 23 0,000 0,07118025 0,0970448 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,07118025 0,09698731 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,07118025 0,09692988 ! osteoblast differentiation GO:0001649 40 23 0,000 0,07118025 0,09687253 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,07118025 0,09681524 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,07118025 0,09675802 ! interaction with host GO:0051701 37 23 0,000 0,07118025 0,09670087 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,07118025 0,09664378 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,07118025 0,09658677 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,07118025 0,09652982 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,07118025 0,09647294 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,07118025 0,09641612 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,07118025 0,09635937 ! cell fate determination GO:0001709 45 23 0,000 0,07118025 0,09630269 ! pentose metabolic process GO:0019321 31 23 0,000 0,07118025 0,09624607 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,07118025 0,09618952 ! spermatid development GO:0007286 33 23 0,000 0,07118025 0,09613304 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,07118025 0,09607663 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,07118025 0,09602028 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,07118025 0,09596399 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,07118025 0,09590777 ! telomere organization GO:0032200 32 23 0,000 0,07118025 0,09585162 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,07118025 0,09579554 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,07118025 0,09573952 ! regulation of amine transport GO:0051952 38 23 0,000 0,07118025 0,09568356 ! liver development GO:0001889 40 23 0,000 0,07118025 0,09562767 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,07415945 0,09957194 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,07415945 0,09951385 ! initiation of viral infection GO:0019059 42 24 0,000 0,07415945 0,09945582 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,07415945 0,09939787 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,07415945 0,09933998 ! superoxide metabolic process GO:0006801 32 24 0,000 0,07415945 0,09928215 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,07415945 0,0992244 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! insulin receptor signaling pathway GO:0008286 40 24 0,000 0,07415945 0,09916671 ! fat cell differentiation GO:0045444 37 24 0,000 0,07415945 0,09910909 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,07415945 0,09905153 ! sperm motility GO:0030317 27 24 0,000 0,07415945 0,09899404 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,07415945 0,09893662 ! vacuole organization GO:0007033 39 24 0,000 0,07415945 0,09887927 ! receptor metabolic process GO:0043112 37 24 0,000 0,07415945 0,09882198 ! response to toxin GO:0009636 38 24 0,000 0,07415945 0,09876476 ! primary neural tube formation GO:0014020 35 24 0,000 0,07415945 0,0987076 ! negative regulation of cell development GO:0010721 56 24 0,000 0,07415945 0,09865051 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,07415945 0,09859349 ! base-excision repair GO:0006284 31 24 0,000 0,07415945 0,09853653 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,07415945 0,09847964 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,07415945 0,09842282 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,07415945 0,09836605 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,07415945 0,09830936 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,07415945 0,09825273 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,07712927 0,10212857 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,07712927 0,1020698 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,07712927 0,10201111 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,07712927 0,10195248 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,07712927 0,10189392 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,07712927 0,10183543 ! peptide transport GO:0015833 43 25 0,000 0,07712927 0,101777 ! male gonad development GO:0008584 33 25 0,000 0,07712927 0,10171865 ! iron ion homeostasis GO:0055072 39 25 0,000 0,07712927 0,10166035 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,07712927 0,10160213 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,07712927 0,10154397 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,07712927 0,10148588 ! phospholipid transport GO:0015914 35 25 0,000 0,07712927 0,10142785 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,07712927 0,1013699 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,07712927 0,101312 ! detection of light stimulus GO:0009583 30 25 0,000 0,07712927 0,10125418 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,07712927 0,10119642 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,07712927 0,10113872 ! leukocyte proliferation GO:0070661 39 25 0,000 0,07712927 0,10108109 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,08008973 0,10490113 ! translational initiation GO:0006413 43 26 0,000 0,08008973 0,10484142 ! regulation of pH GO:0006885 36 26 0,000 0,08008973 0,10478178 ! circadian rhythm GO:0007623 42 26 0,000 0,08008973 0,10472222 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,08008973 0,10466271 ! post-embryonic development GO:0009791 42 26 0,000 0,08008973 0,10460328 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,08008973 0,10454391 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,08008973 0,10448462 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,08008973 0,10442538 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,08008973 0,10436622 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,08008973 0,10430712 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,08008973 0,10424809 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,08008973 0,10418913 ! regulation of coagulation GO:0050818 39 26 0,000 0,08008973 0,10413023 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,08304086 0,10790621 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,08304086 0,10784528 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,08304086 0,10778441 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,08304086 0,10772362 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,08304086 0,1076629 ! catechol metabolic process GO:0009712 43 27 0,000 0,08304086 0,10760224 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,08304086 0,10754166 ! acute-phase response GO:0006953 42 27 0,000 0,08304086 0,10748114 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,08304086 0,10742069 ! myofibril assembly GO:0030239 36 27 0,000 0,08304086 0,10736031 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,08304086 0,10729999 ! response to ionizing radiation GO:0010212 47 27 0,000 0,08304086 0,10723974 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,08304086 0,10717956 ! natural killer cell activation GO:0030101 35 27 0,000 0,08304086 0,10711945 ! lipid oxidation GO:0034440 38 27 0,000 0,08304086 0,10705941 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,08304086 0,10699943 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,08304086 0,10693952 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,08304086 0,10687968 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,08304086 0,1068199 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,08304086 0,10676019 ! gene silencing GO:0016458 41 27 0,000 0,08304086 0,10670055 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,0859827 0,11041887 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,0859827 0,11035726 ! phenol metabolic process GO:0018958 44 28 0,000 0,0859827 0,11029571 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,0859827 0,11023423 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,0859827 0,11017281 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,0859827 0,11011147 ! cell junction assembly GO:0034329 56 28 0,000 0,0859827 0,1100502 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,0859827 0,10998899 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,0859827 0,10992785 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,0859827 0,10986678 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,0859827 0,10980578 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,0859827 0,10974484 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,0859827 0,10968397 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,0859827 0,10962317 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,0859827 0,10956244 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,0859827 0,10950177 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,0859827 0,10944117 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,0859827 0,10938064 ! mesoderm formation GO:0001707 46 28 0,000 0,0859827 0,10932018 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,0859827 0,10925978 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,0859827 0,10919945 ! BMP signaling pathway GO:0030509 40 28 0,000 0,0859827 0,10913918 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,0859827 0,10907899 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,0859827 0,10901885 ! neural tube formation GO:0001841 41 28 0,000 0,0859827 0,10895879 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,0859827 0,10889879 ! placenta development GO:0001890 37 28 0,000 0,0859827 0,10883886 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,08891526 0,11248905 ! regulation of innate immune response GO:0045088 38 29 0,000 0,08891526 0,11242721 ! ovulation cycle process GO:0022602 41 29 0,000 0,08891526 0,11236544 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,08891526 0,11230373 ! protein targeting to membrane GO:0006612 53 29 0,000 0,08891526 0,1122421 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,08891526 0,11218053 ! mismatch repair GO:0006298 34 29 0,000 0,08891526 0,11211902 ! muscle cell development GO:0055001 38 29 0,000 0,08891526 0,11205759 ! formation of primary germ layer GO:0001704 48 29 0,000 0,08891526 0,11199622 ! telencephalon development GO:0021537 52 29 0,000 0,08891526 0,11193492 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,08891526 0,11187369 ! eye morphogenesis GO:0048592 51 29 0,000 0,08891526 0,11181252 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,08891526 0,11175142 ! tissue homeostasis GO:0001894 42 29 0,000 0,08891526 0,11169039 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,09183858 0,11529953 ! collagen metabolic process GO:0032963 40 30 0,000 0,09183858 0,11523663 ! organic anion transport GO:0015711 51 30 0,000 0,09183858 0,11517379 ! cholesterol transport GO:0030301 46 30 0,000 0,09183858 0,11511103 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,09183858 0,11504833 ! spliceosome assembly GO:0000245 49 30 0,000 0,09183858 0,1149857 ! spindle organization GO:0007051 37 30 0,000 0,09183858 0,11492314 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,09183858 0,11486065 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,09183858 0,11479823 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,09183858 0,11473587 ! ceramide metabolic process GO:0006672 43 30 0,000 0,09183858 0,11467358 ! ovulation cycle GO:0042698 43 30 0,000 0,09183858 0,11461136 ! hindbrain development GO:0030902 45 30 0,000 0,09183858 0,11454921 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,09183858 0,11448712 ! adult locomotory behavior GO:0008344 47 30 0,000 0,09183858 0,1144251 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,09183858 0,11436315 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,09183858 0,11430127 ! response to heat GO:0009408 41 30 0,000 0,09183858 0,11423945 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,09183858 0,1141777 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,09183858 0,11411601 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,09475269 0,11767343 ! negative regulation of secretion GO:0051048 49 31 0,000 0,09475269 0,11760993 ! glial cell differentiation GO:0010001 55 31 0,000 0,09475269 0,11754649 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,09475269 0,11748312 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,09475269 0,11741982 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,09475269 0,11735659 ! odontogenesis GO:0042476 50 31 0,000 0,09475269 0,11729343 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,09475269 0,11723033 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,09475269 0,11716731 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,09475269 0,11710435 ! metanephros development GO:0001656 58 31 0,000 0,09475269 0,11704146 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,09475269 0,11697863 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,09475269 0,11691588 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,09475269 0,11685319 ! cell fate specification GO:0001708 37 31 0,000 0,09475269 0,11679056 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,09475269 0,11672801 ! RNA modification GO:0009451 40 31 0,000 0,09475269 0,11666552 ! regulation of muscle development GO:0048634 48 32 0,000 0,09765762 0,12017791 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,09765762 0,12011365 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,09765762 0,12004945 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,09765762 0,11998532 ! meiosis I GO:0007127 52 32 0,000 0,09765762 0,11992126 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,09765762 0,11985727 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,09765762 0,11979334 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,09765762 0,11972949 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,09765762 0,1196657 ! regulation of protein stability GO:0031647 48 32 0,000 0,09765762 0,11960198 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,09765762 0,11953833 ! cytokine production GO:0001816 44 32 0,000 0,09765762 0,11947474 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,09765762 0,11941123 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,09765762 0,11934778 ! vesicle localization GO:0051648 47 32 0,000 0,09765762 0,1192844 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,10055339 0,12275626 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,10055339 0,12269113 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,10055339 0,12262608 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,10055339 0,1225611 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,10055339 0,12249618 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,10055339 0,12243133 ! sister chromatid segregation GO:0000819 46 33 0,000 0,10055339 0,12236655 ! ear morphogenesis GO:0042471 42 33 0,000 0,10055339 0,12230184 ! actomyosin structure organization GO:0031032 43 33 0,000 0,10055339 0,1222372 ! cell junction organization GO:0034330 63 33 0,000 0,10055339 0,12217263 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,10055339 0,12210813 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,10055339 0,12204369 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,10055339 0,12197932 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,10055339 0,12191502 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,10055339 0,12185078 ! female gonad development GO:0008585 49 33 0,000 0,10055339 0,12178662 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,10055339 0,12172252 ! positive regulation of cell development GO:0010720 54 33 0,000 0,10055339 0,12165849 ! lipid homeostasis GO:0055088 55 33 0,000 0,10055339 0,12159453 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,10055339 0,12153063 ! regulation of proteolysis GO:0030162 50 33 0,000 0,10055339 0,1214668 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,10055339 0,12140304 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,10055339 0,12133934 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,10055339 0,12127572 ! cytokinesis GO:0000910 52 33 0,000 0,10055339 0,12121215 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,10055339 0,12114866 ! mRNA catabolic process GO:0006402 48 34 0,000 0,10344003 0,12456129 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,10344003 0,12449611 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,10344003 0,124431 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,10344003 0,12436595 ! feeding behavior GO:0007631 45 34 0,000 0,10344003 0,12430097 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,10344003 0,12423607 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,10344003 0,12417122 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,10344003 0,12410645 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,10344003 0,12404174 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,10344003 0,12397711 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,10344003 0,12391253 ! female gamete generation GO:0007292 43 34 0,000 0,10344003 0,12384803 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,10344003 0,12378359 ! polyol metabolic process GO:0019751 44 34 0,000 0,10344003 0,12371922 ! aerobic respiration GO:0009060 47 34 0,000 0,10344003 0,12365492 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,10344003 0,12359068 ! cellular response to insulin stimulus GO:0032869 52 34 0,000 0,10344003 0,12352651 ! embryonic organ development GO:0048568 45 34 0,000 0,10344003 0,12346241 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,10344003 0,12339837 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,10631757 0,12676538 ! Notch signaling pathway GO:0007219 56 35 0,000 0,10631757 0,1266997 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,10631757 0,12663408 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,10631757 0,12656854 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,10631757 0,12650306 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,10631757 0,12643765 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,10631757 0,12637231 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,10631757 0,12630703 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,10631757 0,12624182 ! glycogen metabolic process GO:0005977 48 35 0,000 0,10631757 0,12617668 ! pigment metabolic process GO:0042440 61 35 0,000 0,10631757 0,12611161 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,10918604 0,12944737 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,10918604 0,12938068 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,10918604 0,12931406 ! negative regulation of binding GO:0051100 58 36 0,000 0,10918604 0,1292475 ! organic ether metabolic process GO:0018904 46 36 0,000 0,10918604 0,12918102 ! neural tube development GO:0021915 50 36 0,000 0,10918604 0,1291146 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,10918604 0,12904825 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,10918604 0,12898197 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,10918604 0,12891576 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,10918604 0,12884961 ! glucan metabolic process GO:0044042 49 36 0,000 0,10918604 0,12878354 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,11204547 0,13208846 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,11204547 0,13202079 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,11204547 0,13195319 ! learning GO:0007612 67 37 0,000 0,11204547 0,13188566 ! ion transmembrane transport GO:0034220 56 37 0,000 0,11204547 0,1318182 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,11204547 0,13175081 ! regulation of protein secretion GO:0050708 51 37 0,000 0,11204547 0,13168348 ! amino acid activation GO:0043038 52 37 0,000 0,11204547 0,13161623 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,11204547 0,13154905 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,11489588 0,1348268 ! gliogenesis GO:0042063 71 38 0,000 0,11489588 0,13475805 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,11489588 0,13468936 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,11489588 0,13462075 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,11489588 0,1345522 ! phagocytosis GO:0006909 60 38 0,000 0,11489588 0,13448373 ! pigmentation GO:0043473 74 38 0,000 0,11489588 0,13441533 ! maintenance of location in cell GO:0051651 69 38 0,000 0,11489588 0,13434699 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,11773731 0,1375995 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,11773731 0,13752961 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,11773731 0,1374598 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,11773731 0,13739006 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,11773731 0,13732039 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,11773731 0,13725079 ! male sex differentiation GO:0046661 53 39 0,000 0,11773731 0,13718126 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,11773731 0,1371118 ! chromatin remodeling GO:0006338 68 39 0,000 0,11773731 0,13704241 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,11773731 0,1369731 ! JNK cascade GO:0007254 54 39 0,000 0,11773731 0,13690385 ! developmental growth GO:0048589 62 39 0,000 0,11773731 0,13683467 ! cell growth GO:0016049 61 39 0,000 0,11773731 0,13676556 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,12056977 0,1399851 ! response to calcium ion GO:0051592 58 40 0,000 0,12056977 0,13991447 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,12056977 0,13984391 ! regulation of tube size GO:0035150 60 40 0,000 0,12056977 0,13977343 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,12056977 0,13970301 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,12056977 0,13963267 ! peptide metabolic process GO:0006518 56 40 0,000 0,12056977 0,1395624 ! inner ear development GO:0048839 57 40 0,000 0,12056977 0,13949219 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,12056977 0,13942206 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,12056977 0,139352 ! double-strand break repair GO:0006302 67 40 0,000 0,12056977 0,13928201 ! B cell differentiation GO:0030183 62 40 0,000 0,12056977 0,13921209 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,12056977 0,13914224 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,12056977 0,13907246 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,12056977 0,13900275 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,12339331 0,14218668 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,12339331 0,14211548 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,12339331 0,14204435 ! glucose transport GO:0015758 52 41 0,000 0,12339331 0,14197329 ! endosome transport GO:0016197 71 41 0,000 0,12339331 0,14190231 ! striated muscle contraction GO:0006941 62 41 0,000 0,12339331 0,14183139 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,12339331 0,14176055 ! biopolymer methylation GO:0043414 62 41 0,000 0,12339331 0,14168977 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,12339331 0,14161907 ! mitochondrial transport GO:0006839 60 42 0,000 0,12620794 0,14477719 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,12620794 0,14470502 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,12620794 0,14463292 ! cellular component disassembly GO:0022411 64 42 0,000 0,12620794 0,14456089 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,12620794 0,14448893 ! hexose transport GO:0008645 54 42 0,000 0,12620794 0,14441705 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,12620794 0,14434523 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,12620794 0,14427349 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,12620794 0,14420182 ! excretion GO:0007588 63 42 0,000 0,12620794 0,14413022 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,12620794 0,14405869 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,12620794 0,14398723 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,12620794 0,14391585 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,12901369 0,14704237 ! neuromuscular process GO:0050905 79 43 0,000 0,12901369 0,14696954 ! activation of caspase activity GO:0006919 65 43 0,000 0,12901369 0,14689678 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,12901369 0,1468241 ! tRNA processing GO:0008033 49 43 0,000 0,12901369 0,14675148 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,12901369 0,14667894 ! vesicle organization GO:0016050 79 43 0,000 0,12901369 0,14660647 ! response to insulin stimulus GO:0032868 63 43 0,000 0,12901369 0,14653407 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,12901369 0,14646175 ! methylation GO:0032259 64 43 0,000 0,12901369 0,14638949 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,1318106 0,14948934 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,1318106 0,14941566 ! glycolysis GO:0006096 53 44 0,000 0,1318106 0,14934206 ! regulation of ion transport GO:0043269 57 44 0,000 0,1318106 0,14926853 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,1318106 0,14919507 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,1318106 0,14912168 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,1318106 0,14904837 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,1318106 0,14897513 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,1318106 0,14890195 ! RNA catabolic process GO:0006401 64 45 0,000 0,13459868 0,15197691 ! regulation of translational initiation GO:0006446 64 45 0,000 0,13459868 0,15190234 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,13459868 0,15182784 ! cell recognition GO:0008037 58 45 0,000 0,13459868 0,15175342 ! cell maturation GO:0048469 60 45 0,000 0,13459868 0,15167907 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,13737797 0,15473523 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,13737797 0,15465949 ! cell redox homeostasis GO:0045454 63 46 0,000 0,13737797 0,15458383 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,13737797 0,15450823 ! regulation of ossification GO:0030278 71 46 0,000 0,13737797 0,15443272 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,13737797 0,15435727 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,1401485 0,15739333 ! viral infectious cycle GO:0019058 71 47 0,000 0,1401485 0,15731652 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,1401485 0,15723978 ! endocrine system development GO:0035270 83 47 0,000 0,1401485 0,15716311 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,1401485 0,15708652 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,1401485 0,15701001 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,1401485 0,15693356 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,1401485 0,1568572 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,1401485 0,15678091 ! chloride transport GO:0006821 67 48 0,000 0,14291028 0,15979273 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,14291028 0,15971508 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 0,000 0,14291028 0,15963751 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,14291028 0,15956002 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,14291028 0,1594826 ! gastrulation GO:0007369 73 48 0,000 0,14291028 0,15940526 ! regulation of DNA replication GO:0006275 75 48 0,000 0,14291028 0,15932799 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,14291028 0,1592508 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,14291028 0,15917368 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,14291028 0,15909663 ! regulation of endocytosis GO:0030100 63 48 0,000 0,14291028 0,15901966 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,14291028 0,15894277 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,14566335 0,16192639 ! sensory perception of smell GO:0007608 61 49 0,000 0,14566335 0,16184817 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,14566335 0,16177002 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,14566335 0,16169194 ! RNA elongation GO:0006354 62 49 0,000 0,14566335 0,16161394 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,14566335 0,16153602 ! germ cell development GO:0007281 68 49 0,000 0,14566335 0,16145817 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,14566335 0,1613804 ! maintenance of location GO:0051235 84 49 0,000 0,14566335 0,1613027 ! regulation of actin filament length GO:0030832 72 50 0,000 0,14840773 0,16426265 ! ear development GO:0043583 72 50 0,000 0,14840773 0,16418364 ! membrane fusion GO:0006944 80 50 0,000 0,14840773 0,16410471 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,14840773 0,16402585 ! lipid modification GO:0030258 73 50 0,000 0,14840773 0,16394706 ! positive regulation of growth GO:0045927 67 50 0,000 0,14840773 0,16386836 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,14840773 0,16378972 ! proton transport GO:0015992 75 50 0,000 0,14840773 0,16371117 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,14840773 0,16363269 ! positive regulation of secretion GO:0051047 71 51 0,000 0,15114346 0,16656922 ! hydrogen transport GO:0006818 77 51 0,000 0,15114346 0,16648944 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,15114346 0,16640974 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,15114346 0,16633012 ! adult behavior GO:0030534 80 51 0,000 0,15114346 0,16625058 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,15114346 0,16617111 ! transition metal ion transport GO:0000041 74 52 0,000 0,15387055 0,16908852 ! regulation of cellular component size GO:0032535 74 52 0,000 0,15387055 0,16900777 ! aging GO:0007568 79 52 0,000 0,15387055 0,1689271 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,15387055 0,1688465 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,15387055 0,16876598 ! establishment of organelle localization GO:0051656 85 52 0,000 0,15387055 0,16868554 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,15658904 0,17158399 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,15658904 0,17150228 ! kidney development GO:0001822 90 53 0,000 0,15658904 0,17142065 ! single fertilization GO:0007338 59 53 0,000 0,15658904 0,1713391 ! cell projection assembly GO:0030031 76 53 0,000 0,15658904 0,17125763 ! amino acid transport GO:0006865 84 54 0,000 0,15929895 0,17413859 ! regulation of mitosis GO:0007088 84 54 0,000 0,15929895 0,17405586 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,15929895 0,17397321 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,15929895 0,17389064 ! DNA catabolic process GO:0006308 67 54 0,000 0,15929895 0,17380815 ! detection of external stimulus GO:0009581 66 54 0,000 0,15929895 0,17372574 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,15929895 0,17364341 ! mesoderm development GO:0007498 76 55 0,000 0,16200031 0,17650436 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,16200031 0,17642079 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,16200031 0,1763373 ! DNA damage response, signal transduction GO:0042770 96 56 0,000 0,16469314 0,17918364 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,16469314 0,17909892 ! carbohydrate transport GO:0008643 74 57 0,000 0,16737747 0,18193204 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,16737747 0,1818461 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,16737747 0,18176024 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,16737747 0,18167446 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,16737747 0,18158877 ! camera-type eye development GO:0043010 88 57 0,000 0,16737747 0,18150315 ! secondary metabolic process GO:0019748 84 57 0,000 0,16737747 0,18141762 ! response to peptide hormone stimulus GO:0043434 84 57 0,000 0,16737747 0,18133217 ! developmental maturation GO:0021700 75 57 0,000 0,16737747 0,18124679 ! gonad development GO:0008406 79 57 0,000 0,16737747 0,1811615 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,17005333 0,18397115 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,17005333 0,18388466 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,17005333 0,18379824 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,17272075 0,18659357 ! activation of MAPK activity GO:0000187 84 59 0,000 0,17272075 0,18650597 ! actin filament organization GO:0007015 95 59 0,000 0,17272075 0,18641845 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,17272075 0,18633101 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,17272075 0,18624365 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,17537974 0,18902221 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,17537974 0,18893368 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,17537974 0,18884522 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,17537974 0,18875686 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,17537974 0,18866857 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,17537974 0,18858036 ! fertilization GO:0009566 68 60 0,000 0,17537974 0,18849224 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,17803034 0,19125165 ! meiosis GO:0007126 96 61 0,000 0,17803034 0,19116236 GO:0051327|M phase of meiotic cell cycle, ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,17803034 0,19107316 ! urogenital system development GO:0001655 101 61 0,000 0,17803034 0,19098404 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,17803034 0,190895 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,17803034 0,19080605 ! extracellular matrix organization GO:0030198 103 61 0,000 0,17803034 0,19071718 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,17803034 0,19062839 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,17803034 0,19053968 ! amine catabolic process GO:0009310 90 62 0,000 0,18067257 0,19327763 ! neurotransmitter transport GO:0006836 81 62 0,000 0,18067257 0,19318778 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,18067257 0,19309801 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,18067257 0,19300832 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,18067257 0,19291871 ! meiotic cell cycle GO:0051321 97 62 0,000 0,18067257 0,19282919 ! organelle localization GO:0051640 96 62 0,000 0,18067257 0,19273975 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,18330646 0,1954589 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,18330646 0,19536833 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,18593203 0,19807488 ! appendage morphogenesis GO:0035107 93 64 0,000 0,18593203 0,19798318 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,18593203 0,19789156 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,18593203 0,19780003 ! hexose catabolic process GO:0019320 82 64 0,000 0,18593203 0,19770858 ! reproductive structure development GO:0048608 90 65 0,000 0,18854931 0,20039899 ! appendage development GO:0048736 94 65 0,000 0,18854931 0,20030643 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,18854931 0,20021395 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,18854931 0,20012156 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,18854931 0,20002925 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,18854931 0,19993703 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,18854931 0,19984489 ! activation of immune response GO:0002253 83 65 0,000 0,18854931 0,19975284 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,19115833 0,20242364 ! antigen processing and presentation GO:0019882 96 66 0,000 0,19115833 0,20233049 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,19115833 0,20223742 ! regulation of immune effector process GO:0002697 101 66 0,000 0,19115833 0,20214444 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,1937591 0,20480052 ! acute inflammatory response GO:0002526 92 68 0,000 0,19635167 0,20744549 ! learning or memory GO:0007611 123 68 0,000 0,19635167 0,20735025 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,19635167 0,20725509 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,19635167 0,20716002 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,19635167 0,20706503 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,19635167 0,20697014 ! rhythmic process GO:0048511 105 68 0,000 0,19635167 0,20687533 ! inorganic anion transport GO:0015698 93 68 0,000 0,19635167 0,2067806 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,19893604 0,20940636 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,19893604 0,20931057 ! response to drug GO:0042493 108 69 0,000 0,19893604 0,20921486 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,19893604 0,20911924 ! response to metal ion GO:0010038 103 70 0,000 0,20151225 0,21173056 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,20151225 0,21163387 ! humoral immune response GO:0006959 86 70 0,000 0,20151225 0,21153728 ! eye development GO:0001654 111 70 0,000 0,20151225 0,21144078 ! amine transport GO:0015837 101 70 0,000 0,20151225 0,21134436 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,20151225 0,21124803 ! regulation of catabolic process GO:0009894 106 70 0,000 0,20151225 0,21115179 ! muscle cell differentiation GO:0042692 104 71 0,000 0,20408033 0,21374534 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,20408033 0,21364805 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,20408033 0,21355084 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,20408033 0,21345373 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,20408033 0,21335671 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,20408033 0,21325977 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,20664029 0,21583682 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,20664029 0,21573884 ! regulation of blood pressure GO:0008217 107 73 0,000 0,20919217 0,21830398 ! tube morphogenesis GO:0035239 118 73 0,000 0,20919217 0,21820498 ! mitochondrion organization GO:0007005 104 73 0,000 0,20919217 0,21810607 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,20919217 0,21800724 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,20919217 0,21790851 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,21173598 0,22045847 ! digestion GO:0007586 97 74 0,000 0,21173598 0,22035871 ! protein import into nucleus GO:0006606 118 74 0,000 0,21173598 0,22025905 ! cellular response to hormone stimulus GO:0032870 109 74 0,000 0,21173598 0,22015947 ! blood coagulation GO:0007596 116 75 0,000 0,21427175 0,22269545 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,21427175 0,22259487 ! response to nutrient GO:0007584 104 75 0,000 0,21427175 0,22249437 ! regulation of ligase activity GO:0051340 114 75 0,000 0,21427175 0,22239397 ! nuclear import GO:0051170 121 75 0,000 0,21427175 0,22229366 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,21427175 0,22219343 ! amine biosynthetic process GO:0009309 97 76 0,000 0,21679952 0,22471334 ! tRNA metabolic process GO:0006399 95 76 0,000 0,21679952 0,22461211 ! response to unfolded protein GO:0006986 99 76 0,000 0,21679952 0,22451098 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,21931929 0,22701817 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,21931929 0,22691605 ! sex differentiation GO:0007548 105 77 0,000 0,21931929 0,22681402 ! protein ubiquitination GO:0016567 125 77 0,000 0,21931929 0,22671208 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,21931929 0,22661023 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,21931929 0,22650848 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,22183111 0,2289998 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,22183111 0,22889706 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,22433498 0,23137689 ! cellular respiration GO:0045333 107 79 0,000 0,22433498 0,23127318 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,22433498 0,23116956 ! T cell activation GO:0042110 134 79 0,000 0,22433498 0,23106604 ! regulation of lyase activity GO:0051339 133 79 0,000 0,22433498 0,23096261 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,22433498 0,23085927 ! alcohol catabolic process GO:0046164 104 80 0,000 0,22683095 0,23332343 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,22683095 0,23321912 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,22683095 0,23311491 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,22683095 0,2330108 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,22931902 0,2354615 ! hemostasis GO:0007599 125 81 0,000 0,22931902 0,23535643 ! mRNA transport GO:0051028 121 81 0,000 0,22931902 0,23525145 ! regulation of cell cycle process GO:0010564 122 81 0,000 0,22931902 0,23514657 ! response to protein stimulus GO:0051789 111 81 0,000 0,22931902 0,23504178 ! regulation of neurological system process GO:0031644 122 81 0,000 0,22931902 0,23493708 ! vitamin metabolic process GO:0006766 103 81 0,000 0,22931902 0,23483248 ! detection of stimulus GO:0051606 108 82 0,000 0,23179923 0,23726668 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,2342716 0,2396907 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,2342716 0,23958412 ! microtubule cytoskeleton organization GO:0000226 120 84 0,000 0,23673616 0,24199696 ! sterol metabolic process GO:0016125 120 84 0,000 0,23673616 0,24188945 ! regulation of DNA metabolic process GO:0051052 135 85 0,000 0,23919292 0,24429117 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,23919292 0,24418274 ! rRNA metabolic process GO:0016072 107 85 0,000 0,23919292 0,24407441 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,23919292 0,24396617 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,24164192 0,24635479 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,24408317 0,2487334 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,24408317 0,24862325 ! female pregnancy GO:0007565 130 87 0,000 0,24408317 0,24851319 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,24408317 0,24840323 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,24651671 0,25076887 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,24651671 0,25065801 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,24651671 0,25054725 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,24651671 0,25043658 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,24651671 0,25032602 ! reproductive developmental process GO:0003006 127 89 0,000 0,24894255 0,25267778 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,24894255 0,25256632 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,24894255 0,25245496 ! leukocyte differentiation GO:0002521 143 90 0,000 0,25136072 0,25479491 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,25136072 0,25468266 ! hormone metabolic process GO:0042445 121 90 0,000 0,25136072 0,25457052 ! RNA localization GO:0006403 135 91 0,000 0,25377124 0,2568987 ! ATP metabolic process GO:0046034 137 91 0,000 0,25377124 0,25678568 ! response to virus GO:0009615 122 91 0,000 0,25377124 0,25667276 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,25617414 0,25898924 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,25617414 0,25887545 ! positive regulation of immune response GO:0050778 121 92 0,000 0,25617414 0,25876175 ! DNA recombination GO:0006310 146 92 0,000 0,25617414 0,25864816 ! sulfur metabolic process GO:0006790 118 92 0,000 0,25617414 0,25853467 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,25856944 0,26083759 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,25856944 0,26072324 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,25856944 0,26060898 ! electron transport chain GO:0022900 123 94 0,000 0,26095716 0,26290033 ! response to oxidative stress GO:0006979 141 94 0,000 0,26095716 0,26278523 ! carboxylic acid transport GO:0046942 147 95 0,000 0,26333733 0,26506602 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,26570997 0,26733724 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,26570997 0,26722035 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,26570997 0,26710355 ! protein maturation GO:0051604 129 96 0,000 0,26570997 0,26698686 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,2680751 0,26924574 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,2680751 0,26912822 ! calcium ion transport GO:0006816 167 99 0,000 0,27278295 0,27373507 ! protein import GO:0017038 156 99 0,000 0,27278295 0,27361569 ! regulation of translation GO:0006417 151 100 0,000 0,27512571 0,27584531 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,27512571 0,27572511 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,27512571 0,27560502 ! divalent metal ion transport GO:0070838 171 100 0,000 0,27512571 0,27548504 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,27512571 0,27536516 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,27512571 0,27524538 ! protein localization in organelle GO:0033365 161 100 0,000 0,27512571 0,27512571