pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6267-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! sarcomere organization GO:0045214 23 19 8,000 3,948E-15 9,081E-12 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 9,000 1,206E-14 1,387E-11 ! actomyosin structure organization GO:0031032 43 33 9,000 2,487E-14 1,906E-11 ! myofibril assembly GO:0030239 36 27 8,000 1,907E-13 1,097E-10 GO:0055002|striated muscle cell development, ! response to calcium ion GO:0051592 58 40 9,000 2,181E-13 1,003E-10 ! muscle cell development GO:0055001 38 29 8,000 4,025E-13 1,543E-10 ! response to metal ion GO:0010038 103 70 10,000 3,145E-12 1,033E-09 ! striated muscle cell differentiation GO:0051146 54 38 8,000 6,199E-12 1,782E-09 ! response to inorganic substance GO:0010035 115 75 10,000 6,904E-12 1,764E-09 ! muscle cell differentiation GO:0042692 104 71 8,000 2,312E-09 5,318E-07 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 3,000 1,363E-08 2,85E-06 ! release of cytochrome c from mitochondria GO:0001836 23 14 4,000 3,694E-08 7,08E-06 ! apoptotic mitochondrial changes GO:0008637 29 18 4,000 1,544E-07 2,732E-05 ! regulation of DNA metabolic process GO:0051052 135 85 7,000 1,989E-07 3,267E-05 ! response to gamma radiation GO:0010332 20 12 3,000 1,297E-06 1,989E-04 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 3,000 3,516E-06 5,054E-04 ! positive regulation of neuron apoptosis GO:0043525 29 15 3,000 3,516E-06 4,757E-04 ! apoptotic cell clearance GO:0043277 13 5 2,000 3,793E-06 4,847E-04 ! negative regulation of survival gene product expression GO:0008634 6 5 2,000 3,793E-06 4,592E-04 ! cytokinesis during cell cycle GO:0033205 9 6 2,000 7,546E-06 8,678E-04 ! neuron apoptosis GO:0051402 8 6 2,000 7,546E-06 8,265E-04 ! cell structure disassembly during apoptosis GO:0006921 24 19 3,000 9,76E-06 1,02E-03 ! apoptotic nuclear changes GO:0030262 24 19 3,000 9,76E-06 9,76E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 1,042E-05 9,989E-04 ! B cell lineage commitment GO:0002326 17 7 2,000 1,313E-05 1,208E-03 ! T cell lineage commitment GO:0002360 12 7 2,000 1,313E-05 1,162E-03 ! regulation of protein homodimerization activity GO:0043496 15 7 2,000 1,313E-05 1,119E-03 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 3,000 1,49E-05 1,224E-03 ! cell aging GO:0007569 32 21 3,000 1,49E-05 1,182E-03 ! activation of caspase activity GO:0006919 65 43 4,000 1,498E-05 1,149E-03 ! mitochondrion organization GO:0007005 104 73 5,000 1,561E-05 1,158E-03 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 1,688E-05 1,213E-03 ! regulation of cell-matrix adhesion GO:0001952 51 22 3,000 1,811E-05 1,262E-03 GO:0010810|regulation of cell-substrate adhesion, ! leukocyte homeostasis GO:0001776 33 22 3,000 1,811E-05 1,225E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 2,09E-05 1,374E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 2,09E-05 1,335E-03 ! response to UV GO:0009411 75 46 4,000 2,096E-05 1,303E-03 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 2,18E-05 1,319E-03 ! regulation of neuron apoptosis GO:0043523 77 47 4,000 2,332E-05 1,375E-03 ! positive regulation of caspase activity GO:0043280 72 48 4,000 2,588E-05 1,488E-03 GO:0010952|positive regulation of peptidase activity, ! regulation of DNA replication GO:0006275 75 48 4,000 2,588E-05 1,452E-03 ! mitochondrial membrane organization GO:0007006 39 24 3,000 2,601E-05 1,424E-03 ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 3,079E-05 1,647E-03 ! oocyte differentiation GO:0009994 12 9 2,000 3,119E-05 1,63E-03 GO:0048599|oocyte development, ! positive regulation of cell migration GO:0030335 92 51 4,000 3,489E-05 1,783E-03 ! response to ionizing radiation GO:0010212 47 27 3,000 4,223E-05 2,112E-03 ! response to X-ray GO:0010165 16 10 2,000 4,431E-05 2,169E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 2,000 4,431E-05 2,123E-03 ! cell junction assembly GO:0034329 56 28 3,000 4,899E-05 2,3E-03 ! positive regulation of cell motion GO:0051272 99 56 4,000 5,51E-05 2,535E-03 ! double-strand break repair via homologous recombination GO:0000724 16 11 2,000 6,06E-05 2,733E-03 GO:0000725|recombinational repair, ! focal adhesion formation GO:0048041 24 11 2,000 6,06E-05 2,681E-03 ! T cell homeostasis GO:0043029 20 11 2,000 6,06E-05 2,63E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 6,06E-05 2,581E-03 GO:0042130|negative regulation of T cell proliferation, ! mammary gland development GO:0030879 57 31 3,000 7,402E-05 3,095E-03 ! in utero embryonic development GO:0001701 147 96 5,000 7,41E-05 3,043E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 3,000 8,411E-05 3,394E-03 ! cell junction organization GO:0034330 63 33 3,000 9,517E-05 3,774E-03 ! nucleus organization GO:0006997 49 33 3,000 9,517E-05 3,71E-03 ! cytokinesis GO:0000910 52 33 3,000 9,517E-05 3,648E-03 ! lymphocyte homeostasis GO:0002260 24 13 2,000 1,039E-04 3,919E-03 ! development of primary male sexual characteristics GO:0046546 44 34 3,000 1,073E-04 3,979E-03 ! regulation of caspase activity GO:0043281 97 65 4,000 1,131E-04 4,127E-03 ! regulation of endopeptidase activity GO:0052548 99 67 4,000 1,306E-04 4,695E-03 ! development of primary sexual characteristics GO:0045137 92 68 4,000 1,402E-04 4,961E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 1,636E-04 5,7E-03 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 1,636E-04 5,615E-03 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! defense response to virus GO:0051607 27 15 2,000 1,636E-04 5,533E-03 ! pigmentation GO:0043473 74 38 3,000 1,669E-04 5,563E-03 ! regulation of peptidase activity GO:0052547 106 72 4,000 1,838E-04 6,04E-03 ! male sex differentiation GO:0046661 53 39 3,000 1,849E-04 5,99E-03 ! regulation of protein binding GO:0043393 27 16 2,000 2,002E-04 6,397E-03 ! oogenesis GO:0048477 23 16 2,000 2,002E-04 6,309E-03 ! double-strand break repair GO:0006302 67 40 3,000 2,043E-04 6,35E-03 ! digestion GO:0007586 97 74 4,000 2,092E-04 6,415E-03 ! blood coagulation GO:0007596 116 75 4,000 2,228E-04 6,744E-03 GO:0050817|coagulation, ! cell-substrate junction assembly GO:0007044 39 17 2,000 2,419E-04 7,224E-03 ! mitochondrial transport GO:0006839 60 42 3,000 2,474E-04 7,296E-03 ! cellular component disassembly GO:0022411 64 42 3,000 2,474E-04 7,203E-03 ! gland development GO:0048732 148 77 4,000 2,521E-04 7,249E-03 ! sex differentiation GO:0007548 105 77 4,000 2,521E-04 7,159E-03 ! negative regulation of T cell activation GO:0050868 25 18 2,000 2,887E-04 8,097E-03 ! hemostasis GO:0007599 125 81 4,000 3,194E-04 8,852E-03 ! response to alkaloid GO:0043279 32 19 2,000 3,41E-04 9,336E-03 ! regulation of cell adhesion GO:0030155 159 83 4,000 3,578E-04 9,681E-03 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 3,000 3,833E-04 0,01025086 ! negative regulation of immune system process GO:0002683 73 47 3,000 3,833E-04 0,01013304 ! positive regulation of MAP kinase activity GO:0043406 121 85 4,000 3,995E-04 0,01044243 ! transcription initiation GO:0006352 118 85 4,000 3,995E-04 0,01032509 ! regulation of membrane potential GO:0042391 128 85 4,000 3,995E-04 0,01021037 ! RNA elongation GO:0006354 62 49 3,000 4,502E-04 0,01137859 ! germ cell development GO:0007281 68 49 3,000 4,502E-04 0,01125491 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 4,63E-04 0,01145127 ! reproductive developmental process GO:0003006 127 89 4,000 4,939E-04 0,01208593 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 1,000 5,243E-04 0,01269369 ! blood coagulation, extrinsic pathway GO:0007598 9 5 1,000 5,243E-04 0,01256147 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 5,243E-04 0,01243197 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 5,243E-04 0,01230511 ! epithelial cell proliferation GO:0050673 6 5 1,000 5,243E-04 0,01218082 ! induction of apoptosis by oxidative stress GO:0008631 5 5 1,000 5,243E-04 0,01205901 ! valine metabolic process GO:0006573 8 5 1,000 5,243E-04 0,01193961 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 1,000 5,243E-04 0,01182256 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 5,243E-04 0,01170777 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 5,243E-04 0,0115952 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 5,243E-04 0,01148477 ! centrosome duplication GO:0051298 5 5 1,000 5,243E-04 0,01137642 ! response to UV-C GO:0010225 6 5 1,000 5,243E-04 0,0112701 ! positive regulation of blood coagulation GO:0030194 10 5 1,000 5,243E-04 0,01116575 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 5,243E-04 0,01106331 ! neural plate development GO:0001840 6 5 1,000 5,243E-04 0,01096273 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 1,000 5,243E-04 0,01086397 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 5,243E-04 0,01076697 ! regulation of fibroblast proliferation GO:0048145 35 22 2,000 5,333E-04 0,01085438 ! vasculogenesis GO:0001570 33 22 2,000 5,333E-04 0,01075917 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 2,000 5,333E-04 0,01066561 ! blastocyst development GO:0001824 37 22 2,000 5,333E-04 0,01057367 ! aging GO:0007568 79 52 3,000 5,656E-04 0,0111184 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 6,042E-04 0,0117776 ! positive regulation of cell adhesion GO:0045785 37 23 2,000 6,1E-04 0,01178998 ! myelination GO:0042552 35 23 2,000 6,1E-04 0,01169173 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 6,1E-04 0,0115951 ! negative regulation of DNA replication GO:0008156 35 23 2,000 6,1E-04 0,01150006 ! DNA catabolic process GO:0006308 67 54 3,000 6,533E-04 0,01221604 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 6,934E-04 0,01286203 ! response to toxin GO:0009636 38 24 2,000 6,934E-04 0,01275913 ! neurotransmitter secretion GO:0007269 32 24 2,000 6,934E-04 0,01265787 ! response to light stimulus GO:0009416 153 96 4,000 6,984E-04 0,01264764 ! regulation of helicase activity GO:0051095 11 6 1,000 7,827E-04 0,01406385 ! male meiosis GO:0007140 7 6 1,000 7,827E-04 0,01395483 ! neuron adhesion GO:0007158 9 6 1,000 7,827E-04 0,01384749 ! cGMP-mediated signaling GO:0019934 10 6 1,000 7,827E-04 0,01374178 ! pigment granule organization GO:0048753 11 6 1,000 7,827E-04 0,01363768 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 7,827E-04 0,01353514 ! ER overload response GO:0006983 7 6 1,000 7,827E-04 0,01343413 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 7,827E-04 0,01333462 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 7,827E-04 0,01323657 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! negative regulation of focal adhesion formation GO:0051895 16 6 1,000 7,827E-04 0,01313995 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 7,827E-04 0,01304473 ! neutrophil homeostasis GO:0001780 6 6 1,000 7,827E-04 0,01295089 ! regulation of macrophage activation GO:0043030 11 6 1,000 7,827E-04 0,01285838 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 7,827E-04 0,01276719 ! axonal fasciculation GO:0007413 9 6 1,000 7,827E-04 0,01267728 ! blastocyst growth GO:0001832 15 6 1,000 7,827E-04 0,01258863 ! negative regulation of B cell activation GO:0050869 9 6 1,000 7,827E-04 0,0125012 ! positive regulation of coagulation GO:0050820 11 6 1,000 7,827E-04 0,01241499 ! male gonad development GO:0008584 33 25 2,000 7,838E-04 0,01234741 ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 7,838E-04 0,01226341 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 8,023E-04 0,01246837 ! gonad development GO:0008406 79 57 3,000 8,023E-04 0,01238469 ! regulation of body fluid levels GO:0050878 154 100 4,000 8,404E-04 0,0128866 ! post-embryonic development GO:0009791 42 26 2,000 8,813E-04 0,01342388 ! actin filament organization GO:0007015 95 59 3,000 9,141E-04 0,01383122 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 9,862E-04 0,0148251 ! cell-matrix adhesion GO:0007160 114 61 3,000 1,036E-03 0,01547792 ! homeostasis of number of cells GO:0048872 84 61 3,000 1,036E-03 0,01537806 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,091E-03 0,01607794 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,091E-03 0,01597553 ! pericardium development GO:0060039 8 7 1,000 1,091E-03 0,01587442 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 1,091E-03 0,01577458 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,091E-03 0,01567599 ! lipoprotein transport GO:0042953 9 7 1,000 1,091E-03 0,01557863 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,091E-03 0,01548246 ! organ growth GO:0035265 11 7 1,000 1,091E-03 0,01538748 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 1,091E-03 0,01529365 ! behavioral fear response GO:0001662 13 7 1,000 1,091E-03 0,01520096 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,091E-03 0,01510939 ! response to UV-B GO:0010224 11 7 1,000 1,091E-03 0,01501892 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,091E-03 0,01492952 ! regulation of focal adhesion formation GO:0051893 17 7 1,000 1,091E-03 0,01484118 ! regulation of lipid transport GO:0032368 13 7 1,000 1,091E-03 0,01475388 ! response to tumor cell GO:0002347 12 7 1,000 1,091E-03 0,0146676 ! neuroblast proliferation GO:0007405 13 7 1,000 1,091E-03 0,01458232 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,091E-03 0,01449803 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 1,000 1,091E-03 0,01441471 GO:0002688|regulation of leukocyte chemotaxis, ! trophectodermal cell differentiation GO:0001829 8 7 1,000 1,091E-03 0,01433234 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 1,000 1,091E-03 0,0142509 ! positive regulation of multicellular organism growth GO:0040018 38 28 2,000 1,099E-03 0,01427631 ! ensheathment of neurons GO:0007272 43 28 2,000 1,099E-03 0,01419611 GO:0008366|axon ensheathment, ! response to organic cyclic substance GO:0014070 47 28 2,000 1,099E-03 0,0141168 ! negative regulation of cell growth GO:0030308 106 62 3,000 1,102E-03 0,01407605 ! negative regulation of cell size GO:0045792 108 64 3,000 1,241E-03 0,01576544 ! reproductive structure development GO:0048608 90 65 3,000 1,315E-03 0,01661326 ! negative regulation of cell activation GO:0050866 44 30 2,000 1,347E-03 0,01693118 ! response to heat GO:0009408 41 30 2,000 1,347E-03 0,01683917 ! cell-substrate adhesion GO:0031589 121 66 3,000 1,392E-03 0,01730076 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,447E-03 0,01789348 ! succinate metabolic process GO:0006105 14 8 1,000 1,447E-03 0,01779779 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,447E-03 0,01770312 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,447E-03 0,01760945 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 1,447E-03 0,01751677 ! melanin metabolic process GO:0006582 12 8 1,000 1,447E-03 0,01742506 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,447E-03 0,01733431 ! multicellular organism growth GO:0035264 14 8 1,000 1,447E-03 0,01724449 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,447E-03 0,0171556 ! regulation of mitochondrial membrane potential GO:0051881 11 8 1,000 1,447E-03 0,01706762 ! myeloid cell homeostasis GO:0002262 8 8 1,000 1,447E-03 0,01698054 ! regulation of fibrinolysis GO:0051917 13 8 1,000 1,447E-03 0,01689435 ! negative regulation of organic acid transport GO:0032891 12 8 1,000 1,447E-03 0,01680902 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,447E-03 0,01672456 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 1,000 1,447E-03 0,01664093 ! metanephros development GO:0001656 58 31 2,000 1,484E-03 0,01697581 ! response to drug GO:0042493 108 69 3,000 1,641E-03 0,018688 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 3,000 1,731E-03 0,01961249 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 1,782E-03 0,02008689 ! female gonad development GO:0008585 49 33 2,000 1,782E-03 0,01998891 ! regulation of activated T cell proliferation GO:0046006 15 9 1,000 1,852E-03 0,02067283 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 1,000 1,852E-03 0,02057296 ! T cell selection GO:0045058 18 9 1,000 1,852E-03 0,02047405 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,852E-03 0,02037609 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 14 9 1,000 1,852E-03 0,02027906 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 1,852E-03 0,02018295 ! thymus development GO:0048538 15 9 1,000 1,852E-03 0,02008775 ! spleen development GO:0048536 15 9 1,000 1,852E-03 0,01999344 ! blastocyst formation GO:0001825 12 9 1,000 1,852E-03 0,01990002 ! embryonic placenta development GO:0001892 12 9 1,000 1,852E-03 0,01980746 ! response to nicotine GO:0035094 16 9 1,000 1,852E-03 0,01971576 ! establishment of cell polarity GO:0030010 12 9 1,000 1,852E-03 0,0196249 ! response to hypoxia GO:0001666 132 72 3,000 1,921E-03 0,02026292 ! female gamete generation GO:0007292 43 34 2,000 1,944E-03 0,02041282 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,944E-03 0,02032003 ! response to steroid hormone stimulus GO:0048545 114 73 3,000 2,021E-03 0,0210282 ! regulation of action potential in neuron GO:0019228 54 35 2,000 2,115E-03 0,02190785 ! response to oxygen levels GO:0070482 137 74 3,000 2,124E-03 0,02190715 ! negative regulation of growth GO:0045926 123 75 3,000 2,231E-03 0,02290914 ! response to reactive oxygen species GO:0000302 55 36 2,000 2,295E-03 0,02345564 ! hormone-mediated signaling GO:0009755 49 36 2,000 2,295E-03 0,02335185 ! development of primary female sexual characteristics GO:0046545 52 36 2,000 2,295E-03 0,02324898 GO:0046660|female sex differentiation, ! regulation of B cell proliferation GO:0030888 15 10 1,000 2,303E-03 0,02323585 ! hair follicle morphogenesis GO:0031069 17 10 1,000 2,303E-03 0,02313438 ! sulfate transport GO:0008272 12 10 1,000 2,303E-03 0,0230338 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 2,303E-03 0,02293409 GO:0010812|negative regulation of cell-substrate adhesion, ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 2,303E-03 0,02283523 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 1,000 2,303E-03 0,02273723 ! B cell proliferation GO:0042100 14 10 1,000 2,303E-03 0,02264006 ! phagocytosis, engulfment GO:0006911 20 10 1,000 2,303E-03 0,02254372 ! fear response GO:0042596 16 10 1,000 2,303E-03 0,02244819 ! negative regulation of ossification GO:0030279 19 10 1,000 2,303E-03 0,02235348 ! alpha-beta T cell activation GO:0046631 16 10 1,000 2,303E-03 0,02225955 ! DNA methylation GO:0006306 15 10 1,000 2,303E-03 0,02216642 GO:0006305|DNA alkylation, ! positive regulation of leukocyte migration GO:0002687 23 10 1,000 2,303E-03 0,02207406 ! nitric oxide mediated signal transduction GO:0007263 17 10 1,000 2,303E-03 0,02198246 ! regulation of T cell proliferation GO:0042129 58 38 2,000 2,682E-03 0,02549365 ! phagocytosis GO:0006909 60 38 2,000 2,682E-03 0,02538874 ! mesenchymal cell development GO:0014031 64 38 2,000 2,682E-03 0,02528469 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,802E-03 0,02630237 ! mitotic spindle organization GO:0007052 15 11 1,000 2,802E-03 0,02619545 ! regulation of intracellular pH GO:0051453 17 11 1,000 2,802E-03 0,0260894 ! nitric oxide metabolic process GO:0046209 14 11 1,000 2,802E-03 0,0259842 GO:0006809|nitric oxide biosynthetic process, ! regulation of leukocyte migration GO:0002685 24 11 1,000 2,802E-03 0,02587985 ! male genitalia development GO:0030539 13 11 1,000 2,802E-03 0,02577633 ! digestive tract morphogenesis GO:0048546 15 11 1,000 2,802E-03 0,02567363 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! regulation of organic acid transport GO:0032890 17 11 1,000 2,802E-03 0,02557175 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 2,000 2,89E-03 0,02627724 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 2,89E-03 0,02617379 ! multicellular organismal metabolic process GO:0044236 50 39 2,000 2,89E-03 0,02607115 ! chromatin remodeling GO:0006338 68 39 2,000 2,89E-03 0,02596931 ! developmental growth GO:0048589 62 39 2,000 2,89E-03 0,02586826 ! T cell differentiation GO:0030217 65 40 2,000 3,108E-03 0,02770961 ! B cell differentiation GO:0030183 62 40 2,000 3,108E-03 0,02760263 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 3,346E-03 0,02959971 ! cell-cell junction assembly GO:0007043 18 12 1,000 3,346E-03 0,02948631 ! negative regulation of endothelial cell migration GO:0010596 21 12 1,000 3,346E-03 0,02937376 ! regulation of interleukin-12 production GO:0032655 16 12 1,000 3,346E-03 0,02926208 ! gland morphogenesis GO:0022612 23 12 1,000 3,346E-03 0,02915123 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 1,000 3,346E-03 0,02904123 ! cell cycle arrest GO:0007050 150 86 3,000 3,665E-03 0,03169069 ! interphase of mitotic cell cycle GO:0051329 156 86 3,000 3,665E-03 0,031572 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 2,000 3,821E-03 0,03279353 ! DNA-dependent DNA replication GO:0006261 59 43 2,000 3,821E-03 0,03267162 ! response to insulin stimulus GO:0032868 63 43 2,000 3,821E-03 0,03255061 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 3,821E-03 0,0324305 ! response to hexose stimulus GO:0009746 19 13 1,000 3,936E-03 0,0332784 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 3,936E-03 0,0331565 ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 3,936E-03 0,03303549 ! regulation of DNA repair GO:0006282 15 13 1,000 3,936E-03 0,03291536 ! negative regulation of protein import into nucleus GO:0042308 25 13 1,000 3,936E-03 0,0327961 ! genitalia development GO:0048806 15 13 1,000 3,936E-03 0,03267771 ! regulation of cellular pH GO:0030641 20 13 1,000 3,936E-03 0,03256016 ! cellular pigmentation GO:0033059 24 13 1,000 3,936E-03 0,03244346 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 1,000 3,936E-03 0,03232759 ! interphase GO:0051325 159 88 3,000 3,98E-03 0,03257552 ! regulation of action potential GO:0001508 71 44 2,000 4,079E-03 0,03326882 ! negative regulation of cell migration GO:0030336 92 44 2,000 4,079E-03 0,03315126 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 2,000 4,079E-03 0,03303453 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 4,079E-03 0,03291862 ! regulation of neurogenesis GO:0050767 153 89 3,000 4,144E-03 0,03332525 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 4,347E-03 0,0348388 ! response to virus GO:0009615 122 91 3,000 4,486E-03 0,03582253 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 4,57E-03 0,03636648 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 4,57E-03 0,03624108 ! regulation of S phase GO:0033261 18 14 1,000 4,57E-03 0,03611654 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 4,57E-03 0,03599285 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 1,000 4,57E-03 0,03587001 ! epidermis morphogenesis GO:0048730 29 14 1,000 4,57E-03 0,035748 ! cellular response to starvation GO:0009267 21 14 1,000 4,57E-03 0,03562682 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 4,57E-03 0,03550646 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 4,57E-03 0,03538691 ! G1/S transition checkpoint GO:0031575 33 14 1,000 4,57E-03 0,03526816 ! DNA unwinding during replication GO:0006268 21 14 1,000 4,57E-03 0,03515021 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 4,57E-03 0,03503304 ! synaptic transmission, cholinergic GO:0007271 21 14 1,000 4,57E-03 0,03491665 ! cell fate commitment GO:0045165 141 92 3,000 4,663E-03 0,03551562 ! response to estrogen stimulus GO:0043627 74 47 2,000 4,915E-03 0,03731044 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 4,915E-03 0,03718771 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! response to oxidative stress GO:0006979 141 94 3,000 5,033E-03 0,03795343 ! response to temperature stimulus GO:0009266 62 48 2,000 5,215E-03 0,03919928 ! regulation of binding GO:0051098 151 95 3,000 5,225E-03 0,03914432 ! metencephalon development GO:0022037 19 15 1,000 5,247E-03 0,03918488 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 5,247E-03 0,03905806 ! centrosome cycle GO:0007098 16 15 1,000 5,247E-03 0,03893207 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 5,247E-03 0,03880689 ! neuron recognition GO:0008038 22 15 1,000 5,247E-03 0,03868251 ! embryonic hindlimb morphogenesis GO:0035116 25 15 1,000 5,247E-03 0,03855892 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 5,247E-03 0,03843612 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 5,247E-03 0,0383141 ! regulation of angiogenesis GO:0045765 94 49 2,000 5,526E-03 0,04022067 ! ear development GO:0043583 72 50 2,000 5,848E-03 0,04242762 ! positive regulation of growth GO:0045927 67 50 2,000 5,848E-03 0,0422942 ! regulation of multicellular organism growth GO:0040014 65 50 2,000 5,848E-03 0,04216162 ! neural crest cell migration GO:0001755 24 16 1,000 5,968E-03 0,04289775 ! G1 phase GO:0051318 27 16 1,000 5,968E-03 0,04276411 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 5,968E-03 0,04263131 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 6,18E-03 0,04400829 ! negative regulation of cell motion GO:0051271 104 51 2,000 6,18E-03 0,04387247 ! nucleotide-excision repair GO:0006289 64 52 2,000 6,524E-03 0,04617022 ! forelimb morphogenesis GO:0035136 19 17 1,000 6,732E-03 0,04749514 ! regulation of viral genome replication GO:0045069 24 17 1,000 6,732E-03 0,04734989 ! DNA duplex unwinding GO:0032508 25 17 1,000 6,732E-03 0,04720553 GO:0032392|DNA geometric change, ! actin filament bundle formation GO:0051017 26 17 1,000 6,732E-03 0,04706205 ! neuromuscular junction development GO:0007528 23 17 1,000 6,732E-03 0,04691944 ! long-chain fatty acid transport GO:0015909 24 17 1,000 6,732E-03 0,04677769 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 6,732E-03 0,04663679 ! peptidyl-serine modification GO:0018209 27 17 1,000 6,732E-03 0,04649674 ! cell-cell junction organization GO:0045216 25 17 1,000 6,732E-03 0,04635753 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 6,732E-03 0,04621915 ! regulation of neurotransmitter levels GO:0001505 73 53 2,000 6,879E-03 0,04708837 ! kidney development GO:0001822 90 53 2,000 6,879E-03 0,04694864 ! positive regulation of DNA replication GO:0045740 29 18 1,000 7,537E-03 0,05128948 ! positive regulation of translation GO:0045727 28 18 1,000 7,537E-03 0,05113819 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 7,537E-03 0,05098778 ! transcription from RNA polymerase III promoter GO:0006383 32 18 1,000 7,537E-03 0,05083826 ! response to carbohydrate stimulus GO:0009743 24 18 1,000 7,537E-03 0,05068961 ! pigmentation during development GO:0048066 31 18 1,000 7,537E-03 0,05054182 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 7,537E-03 0,0503949 ! peptide cross-linking GO:0018149 31 18 1,000 7,537E-03 0,05024883 ! cellular response to nutrient levels GO:0031669 27 18 1,000 7,537E-03 0,0501036 ! gut development GO:0048565 26 18 1,000 7,537E-03 0,04995921 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 7,537E-03 0,04981565 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 8,012E-03 0,05279985 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 8,384E-03 0,05509455 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 8,384E-03 0,05493758 ! regeneration GO:0031099 32 19 1,000 8,384E-03 0,05478151 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 8,384E-03 0,05462632 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 8,384E-03 0,05447201 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 8,384E-03 0,05431857 ! response to starvation GO:0042594 30 19 1,000 8,384E-03 0,05416599 ! sex determination GO:0007530 29 19 1,000 8,384E-03 0,05401426 ! plasma membrane fusion GO:0045026 23 19 1,000 8,384E-03 0,05386339 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 8,384E-03 0,05371335 ! renal system process GO:0003014 35 19 1,000 8,384E-03 0,05356414 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 8,384E-03 0,05341577 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 8,412E-03 0,05344851 ! multicellular organism reproduction GO:0032504 83 57 2,000 8,412E-03 0,05330127 GO:0048609|reproductive process in a multicellular organism, ! negative regulation of kinase activity GO:0033673 100 58 2,000 8,824E-03 0,05575886 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 2,000 9,248E-03 0,05827643 ! activation of MAPK activity GO:0000187 84 59 2,000 9,248E-03 0,0581172 ! hindlimb morphogenesis GO:0035137 32 20 1,000 9,271E-03 0,05810269 ! response to ethanol GO:0045471 37 20 1,000 9,271E-03 0,05794481 ! multicellular organismal response to stress GO:0033555 32 20 1,000 9,271E-03 0,05778777 ! DNA modification GO:0006304 28 20 1,000 9,271E-03 0,05763159 ! positive regulation of locomotion GO:0040017 35 20 1,000 9,271E-03 0,05747625 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen catabolic process GO:0030574 25 20 1,000 9,271E-03 0,05732174 ! regulation of homeostatic process GO:0032844 105 60 2,000 9,684E-03 0,05971187 ! meiosis GO:0007126 96 61 2,000 0,01013099 0,06230285 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 2,000 0,01013099 0,06213671 ! negative regulation of transferase activity GO:0051348 105 61 2,000 0,01013099 0,06197145 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 0,01019834 0,062218 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 0,01019834 0,0620534 ! regulation of chemotaxis GO:0050920 36 21 1,000 0,01019834 0,06188967 ! ovarian follicle development GO:0001541 30 21 1,000 0,01019834 0,0617268 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01019834 0,06156479 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 0,01019834 0,06140363 ! fatty acid transport GO:0015908 30 21 1,000 0,01019834 0,0612433 ! platelet activation GO:0030168 28 21 1,000 0,01019834 0,06108382 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01019834 0,06092516 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01019834 0,06076732 ! nerve-nerve synaptic transmission GO:0007270 36 21 1,000 0,01019834 0,0606103 ! response to cytokine stimulus GO:0034097 47 21 1,000 0,01019834 0,06045409 ! negative regulation of cytokine production GO:0001818 31 21 1,000 0,01019834 0,06029868 ! neurotransmitter transport GO:0006836 81 62 2,000 0,01059011 0,06245447 ! meiotic cell cycle GO:0051321 97 62 2,000 0,01059011 0,06229474 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01116485 0,06550803 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01116485 0,06534135 ! viral genome replication GO:0019079 29 22 1,000 0,01116485 0,06517551 ! molting cycle process GO:0022404 40 22 1,000 0,01116485 0,0650105 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01116485 0,06484634 ! glutamate signaling pathway GO:0007215 34 22 1,000 0,01116485 0,064683 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01116485 0,06452048 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01116485 0,06435877 GO:0051297|centrosome organization, ! ureteric bud development GO:0001657 32 22 1,000 0,01116485 0,06419787 ! regulation of behavior GO:0050795 38 22 1,000 0,01116485 0,06403778 ! regulation of blood coagulation GO:0030193 34 22 1,000 0,01116485 0,06387848 ! protein tetramerization GO:0051262 39 22 1,000 0,01116485 0,06371997 ! B cell activation GO:0042113 104 65 2,000 0,01203908 0,06853929 ! protein oligomerization GO:0051259 100 65 2,000 0,01203908 0,06837006 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01217007 0,06894375 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01217007 0,06877436 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01217007 0,06860579 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,01217007 0,06843805 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01217007 0,06827113 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01217007 0,06810502 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01217007 0,06793972 ! axon guidance GO:0007411 99 66 2,000 0,0125461 0,06986932 ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,01306521 0,07258452 ! regulation of endothelial cell proliferation GO:0001936 46 24 1,000 0,0132134 0,0732309 ! neural crest cell development GO:0014032 39 24 1,000 0,0132134 0,07305486 GO:0014033|neural crest cell differentiation, ! primary neural tube formation GO:0014020 35 24 1,000 0,0132134 0,07287967 ! negative regulation of cell development GO:0010721 56 24 1,000 0,0132134 0,07270532 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 0,0132134 0,0725318 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01429424 0,07827797 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,01429424 0,07809203 ! leukocyte proliferation GO:0070661 39 25 1,000 0,01429424 0,07790698 GO:0032943|mononuclear cell proliferation, ! positive regulation of phosphorylation GO:0042327 102 70 2,000 0,0146955 0,0799046 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,01526336 0,0827965 ! translational initiation GO:0006413 43 26 1,000 0,01541198 0,08340602 ! regulation of pH GO:0006885 36 26 1,000 0,01541198 0,08321023 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01541198 0,08301536 ! negative regulation of protein modification process GO:0031400 50 26 1,000 0,01541198 0,0828214 ! multicellular organismal catabolic process GO:0044243 32 26 1,000 0,01541198 0,08262834 ! regulation of coagulation GO:0050818 39 26 1,000 0,01541198 0,08243618 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 0,01584348 0,08454755 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of transport GO:0051051 116 73 2,000 0,01643589 0,08750589 ! tube morphogenesis GO:0035239 118 73 2,000 0,01643589 0,08730379 ! regulation of actin filament depolymerization GO:0030834 39 27 1,000 0,01656604 0,0877924 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01656604 0,08759058 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,01656604 0,08738969 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01656604 0,08718971 ! response to nutrient GO:0007584 104 75 2,000 0,01765767 0,09272295 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01775584 0,09302606 ! neural tube formation GO:0001841 41 28 1,000 0,01775584 0,09281464 ! placenta development GO:0001890 37 28 1,000 0,01775584 0,09260417 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01775584 0,09239466 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,0189808 0,09854593 ! ovulation cycle process GO:0022602 41 29 1,000 0,0189808 0,09832398 ! regulation of protein import into nucleus GO:0042306 53 29 1,000 0,0189808 0,09810302 ! tissue homeostasis GO:0001894 42 29 1,000 0,0189808 0,09788306 GO:0048871|multicellular organismal homeostasis, ! collagen metabolic process GO:0032963 40 30 1,000 0,02024035 0,10414498 ! cholesterol transport GO:0030301 46 30 1,000 0,02024035 0,10391251 GO:0015918|sterol transport, ! spindle organization GO:0007051 37 30 1,000 0,02024035 0,10368108 ! ovulation cycle GO:0042698 43 30 1,000 0,02024035 0,10345068 ! hindbrain development GO:0030902 45 30 1,000 0,02024035 0,1032213 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,02024035 0,10299293 ! T cell activation GO:0042110 134 79 2,000 0,0202496 0,10281252 ! DNA damage checkpoint GO:0000077 53 31 1,000 0,02153392 0,10909256 ! xenobiotic metabolic process GO:0006805 44 31 1,000 0,02153392 0,1088528 ! odontogenesis GO:0042476 50 31 1,000 0,02153392 0,10861409 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,02153392 0,10837642 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02153392 0,10813979 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02153392 0,10790419 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,02161992 0,10809961 ! regulation of muscle development GO:0048634 48 32 1,000 0,02286096 0,11405687 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,02286096 0,11381 ! meiosis I GO:0007127 52 32 1,000 0,02286096 0,11356419 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,02286096 0,11331944 ! peripheral nervous system development GO:0007422 53 32 1,000 0,02286096 0,11307574 ! regulation of protein stability GO:0031647 48 32 1,000 0,02286096 0,11283309 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,02376849 0,11706108 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,02422092 0,11903445 ! ear morphogenesis GO:0042471 42 33 1,000 0,02422092 0,11878064 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 1,000 0,02422092 0,11852792 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02422092 0,11827627 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02422092 0,11802568 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,02422092 0,11777616 ! regulation of protein localization GO:0032880 132 85 2,000 0,0245095 0,11892794 ! negative regulation of multicellular organismal process GO:0051241 133 85 2,000 0,0245095 0,11867757 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,02561325 0,12376151 ! establishment or maintenance of cell polarity GO:0007163 61 34 1,000 0,02561325 0,12350205 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 0,02561325 0,12324368 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,02561325 0,12298639 ! neuron migration GO:0001764 46 34 1,000 0,02561325 0,12273016 ! female pregnancy GO:0007565 130 87 2,000 0,02602872 0,12446164 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,02703741 0,1290167 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,02703741 0,12874959 ! Rho protein signal transduction GO:0007266 51 35 1,000 0,02703741 0,12848358 ! pigment metabolic process GO:0042440 61 35 1,000 0,02703741 0,12821866 ! protein homooligomerization GO:0051260 52 35 1,000 0,02703741 0,12795484 ! regulation of T cell activation GO:0050863 128 89 2,000 0,02759748 0,13033718 ! leukocyte differentiation GO:0002521 143 90 2,000 0,02840041 0,1338544 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,02849287 0,13401556 ! negative regulation of binding GO:0051100 58 36 1,000 0,02849287 0,13374206 ! neural tube development GO:0021915 50 36 1,000 0,02849287 0,13346968 ! response to xenobiotic stimulus GO:0009410 50 36 1,000 0,02849287 0,1331984 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,02997911 0,13986196 ! DNA recombination GO:0006310 146 92 2,000 0,0300433 0,1398777 ! monocarboxylic acid transport GO:0015718 62 38 1,000 0,03149559 0,14634316 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,03304181 0,15321809 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,03304181 0,15290981 ! JNK cascade GO:0007254 54 39 1,000 0,03304181 0,15260276 ! synapse organization GO:0050808 55 39 1,000 0,03304181 0,15229694 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 0,03436554 0,15808148 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 1,000 0,03461726 0,15892157 ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,03461726 0,15860499 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03461726 0,15828967 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,03461726 0,15797561 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,03461726 0,15766278 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03608097 0,16400442 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03608097 0,16368094 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03608097 0,16335873 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03608097 0,16303779 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03608097 0,16271811 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03608097 0,16239968 ! sleep GO:0030431 11 5 0,000 0,03608097 0,16208249 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03608097 0,16176654 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03608097 0,16145182 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03608097 0,16113832 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03608097 0,16082604 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03608097 0,16051496 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03608097 0,16020509 ! tongue development GO:0043586 6 5 0,000 0,03608097 0,15989641 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03608097 0,15958891 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03608097 0,1592826 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03608097 0,15897746 ! cobalt ion transport GO:0006824 9 5 0,000 0,03608097 0,15867349 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03608097 0,15837068 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03608097 0,15806902 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03608097 0,15776851 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03608097 0,15746914 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03608097 0,1571709 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03608097 0,15687379 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03608097 0,1565778 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03608097 0,15628293 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03608097 0,15598916 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03608097 0,1556965 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03608097 0,15540494 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03608097 0,15511446 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03608097 0,15482507 ! malate metabolic process GO:0006108 7 5 0,000 0,03608097 0,15453675 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03608097 0,15424951 ! behavioral response to pain GO:0048266 7 5 0,000 0,03608097 0,15396333 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03608097 0,15367821 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03608097 0,15339415 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03608097 0,15311114 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03608097 0,15282916 ! mating behavior GO:0007617 6 5 0,000 0,03608097 0,15254823 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03608097 0,15226832 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03608097 0,15198944 ! rhythmic behavior GO:0007622 12 5 0,000 0,03608097 0,15171158 ! copulation GO:0007620 7 5 0,000 0,03608097 0,15143474 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03608097 0,1511589 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03608097 0,15088406 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03608097 0,15061023 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03608097 0,15033738 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03608097 0,15006553 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03608097 0,14979465 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03608097 0,14952475 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03608097 0,14925582 ! response to protozoan GO:0001562 9 5 0,000 0,03608097 0,14898786 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03608097 0,14872085 ! lymph vessel development GO:0001945 7 5 0,000 0,03608097 0,1484548 ! endochondral ossification GO:0001958 12 5 0,000 0,03608097 0,14818971 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03608097 0,14792555 ! parathyroid gland development GO:0060017 8 5 0,000 0,03608097 0,14766234 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03608097 0,14740006 ! anagen GO:0042640 6 5 0,000 0,03608097 0,14713872 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03608097 0,14687829 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03608097 0,14661879 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,03608097 0,1463602 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03608097 0,14610253 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03608097 0,14584576 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03608097 0,14558989 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03608097 0,14533491 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03608097 0,14508083 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03608097 0,14482764 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03608097 0,14457532 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03608097 0,14432389 ! ovulation GO:0030728 6 5 0,000 0,03608097 0,14407333 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03608097 0,14382363 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03608097 0,1435748 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,03608097 0,14332683 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03608097 0,14307972 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03608097 0,14283345 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03608097 0,14258803 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03608097 0,14234346 ! polyol catabolic process GO:0046174 7 5 0,000 0,03608097 0,14209972 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03608097 0,14185681 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03608097 0,14161474 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03608097 0,14137348 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03608097 0,14113305 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03608097 0,14089344 ! urea metabolic process GO:0019627 6 5 0,000 0,03608097 0,14065464 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03608097 0,14041664 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03608097 0,14017945 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03608097 0,13994306 ! neutrophil activation GO:0042119 5 5 0,000 0,03608097 0,13970747 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03608097 0,13947266 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03608097 0,13923865 ! response to food GO:0032094 5 5 0,000 0,03608097 0,13900542 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03608097 0,13877297 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03608097 0,13854129 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03608097 0,13831039 ! forebrain neuron development GO:0021884 7 5 0,000 0,03608097 0,13808026 ! melanosome organization GO:0032438 7 5 0,000 0,03608097 0,13785089 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03608097 0,13762228 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03608097 0,13739443 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03608097 0,13716733 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03608097 0,13694098 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03608097 0,13671538 ! nucleoside transport GO:0015858 6 5 0,000 0,03608097 0,13649052 ! nucleoside salvage GO:0043174 7 5 0,000 0,03608097 0,1362664 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03608097 0,13604301 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03608097 0,13582035 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03608097 0,13559842 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03608097 0,13537722 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03608097 0,13515674 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03608097 0,13493697 ! depyrimidination GO:0045008 8 5 0,000 0,03608097 0,13471791 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03608097 0,13449957 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03608097 0,13428193 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03608097 0,134065 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03608097 0,13384877 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03608097 0,13363323 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03608097 0,13341839 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03608097 0,13320423 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03608097 0,13299076 ! monocyte differentiation GO:0030224 8 5 0,000 0,03608097 0,13277798 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03608097 0,13256587 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03608097 0,13235444 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03608097 0,13214369 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03608097 0,1319336 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03608097 0,13172418 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03608097 0,13151543 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03608097 0,13130733 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03608097 0,1310999 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03608097 0,13089312 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03608097 0,13068699 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03608097 0,1304815 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03608097 0,13027667 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03608097 0,13007247 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,03608097 0,12986891 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03608097 0,12966599 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03608097 0,12946371 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03608097 0,12926205 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03608097 0,12906102 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03608097 0,12886061 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03608097 0,12866083 ! neural tube patterning GO:0021532 6 5 0,000 0,03608097 0,12846167 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03608097 0,12826312 ! histone demethylation GO:0016577 9 5 0,000 0,03608097 0,12806518 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03608097 0,12786785 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03608097 0,12767113 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03608097 0,12747502 ! enteric nervous system development GO:0048484 8 5 0,000 0,03608097 0,1272795 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03608097 0,12708459 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03608097 0,12689027 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03608097 0,12669654 ! transcription termination GO:0006353 8 5 0,000 0,03608097 0,12650341 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03608097 0,12631086 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,03608097 0,1261189 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,03608097 0,12592752 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03608097 0,12573672 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03608097 0,1255465 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03608097 0,12535685 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03608097 0,12516778 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03608097 0,12497927 ! apical protein localization GO:0045176 6 5 0,000 0,03608097 0,12479133 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03608097 0,12460396 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03608097 0,12441714 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03608097 0,12423089 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03608097 0,1240452 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03608097 0,12386005 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03608097 0,12367546 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03608097 0,12349142 ! glial cell migration GO:0008347 10 5 0,000 0,03608097 0,12330793 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03608097 0,12312498 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03608097 0,12294257 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03608097 0,1227607 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03608097 0,12257937 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03608097 0,12239858 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03608097 0,12221831 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03608097 0,12203858 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03608097 0,12185938 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03608097 0,1216807 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03608097 0,12150254 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03608097 0,12132491 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03608097 0,12114779 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03608097 0,12097119 ! spindle assembly GO:0051225 5 5 0,000 0,03608097 0,1207951 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03608097 0,12061953 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03608097 0,12044446 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03608097 0,12026991 ! organ regeneration GO:0031100 7 5 0,000 0,03608097 0,12009585 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03608097 0,11992231 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03608097 0,11974926 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03608097 0,11957671 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03608097 0,11940466 GO:0055081|anion homeostasis, ! extracellular structure organization GO:0043062 156 99 2,000 0,03617994 0,11956014 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03622143 0,11952554 ! glucose transport GO:0015758 52 41 1,000 0,03622143 0,1193543 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,03622143 0,11918355 ! biopolymer methylation GO:0043414 62 41 1,000 0,03622143 0,11901329 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,03785383 0,12419945 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,03785383 0,12402253 ! hexose transport GO:0008645 54 42 1,000 0,03785383 0,12384611 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,03785383 0,12367019 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,03785383 0,12349477 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,03951396 0,12872821 ! vesicle organization GO:0016050 79 43 1,000 0,03951396 0,12854613 ! methylation GO:0032259 64 43 1,000 0,03951396 0,12836457 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,04120134 0,13365738 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,04120134 0,13346913 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,04291548 0,13882645 ! cell recognition GO:0008037 58 45 1,000 0,04291548 0,13863147 ! cell maturation GO:0048469 60 45 1,000 0,04291548 0,13843704 ! tRNA transcription GO:0009304 11 6 0,000 0,04314063 0,13896841 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04314063 0,13877405 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04314063 0,13858023 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04314063 0,13838696 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04314063 0,13819422 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04314063 0,13800201 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04314063 0,13781034 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04314063 0,13761921 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04314063 0,1374286 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04314063 0,13723852 ! prostate gland development GO:0030850 9 6 0,000 0,04314063 0,13704896 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04314063 0,13685993 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04314063 0,13667142 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04314063 0,13648342 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04314063 0,13629595 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04314063 0,13610898 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04314063 0,13592253 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04314063 0,13573659 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04314063 0,13555116 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,04314063 0,13536623 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,04314063 0,13518181 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04314063 0,13499789 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04314063 0,13481447 ! signal peptide processing GO:0006465 8 6 0,000 0,04314063 0,13463154 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04314063 0,13444912 ! mRNA stabilization GO:0048255 15 6 0,000 0,04314063 0,13426718 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04314063 0,13408574 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04314063 0,13390479 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04314063 0,13372432 ! opsonization GO:0008228 8 6 0,000 0,04314063 0,13354434 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04314063 0,13336485 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04314063 0,13318584 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04314063 0,1330073 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04314063 0,13282925 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04314063 0,13265167 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04314063 0,13247456 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04314063 0,13229793 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04314063 0,13212177 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04314063 0,13194607 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04314063 0,13177085 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04314063 0,13159608 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04314063 0,13142179 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04314063 0,13124795 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04314063 0,13107457 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04314063 0,13090165 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04314063 0,13072918 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04314063 0,13055717 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04314063 0,13038561 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04314063 0,1302145 ! thymic T cell selection GO:0045061 12 6 0,000 0,04314063 0,13004384 ! protein lipoylation GO:0009249 10 6 0,000 0,04314063 0,12987362 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04314063 0,12970385 ! drug transport GO:0015893 6 6 0,000 0,04314063 0,12953453 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04314063 0,12936564 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04314063 0,1291972 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04314063 0,12902919 ! histidine metabolic process GO:0006547 6 6 0,000 0,04314063 0,12886162 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04314063 0,12869449 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04314063 0,12852778 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04314063 0,12836151 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04314063 0,12819567 ! adenohypophysis development GO:0021984 10 6 0,000 0,04314063 0,12803026 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04314063 0,12786527 ! hyperosmotic response GO:0006972 8 6 0,000 0,04314063 0,12770071 ! microtubule nucleation GO:0007020 10 6 0,000 0,04314063 0,12753657 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04314063 0,12737285 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04314063 0,12720955 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04314063 0,12704667 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04314063 0,1268842 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04314063 0,12672216 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! response to dietary excess GO:0002021 7 6 0,000 0,04314063 0,12656052 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04314063 0,1263993 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04314063 0,12623848 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04314063 0,12607808 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04314063 0,12591808 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04314063 0,12575849 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04314063 0,1255993 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04314063 0,12544052 ! organic alcohol transport GO:0015850 9 6 0,000 0,04314063 0,12528213 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04314063 0,12512415 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04314063 0,12496656 ! male sex determination GO:0030238 9 6 0,000 0,04314063 0,12480937 ! carnitine transport GO:0015879 8 6 0,000 0,04314063 0,12465257 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04314063 0,12449617 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04314063 0,12434016 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04314063 0,12418454 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04314063 0,12402931 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04314063 0,12387447 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04314063 0,12372001 ! parturition GO:0007567 12 6 0,000 0,04314063 0,12356594 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04314063 0,12341225 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04314063 0,12325894 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04314063 0,12310601 ! spindle checkpoint GO:0031577 14 6 0,000 0,04314063 0,12295347 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04314063 0,1228013 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04314063 0,1226495 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04314063 0,12249808 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04314063 0,12234704 ! macrophage differentiation GO:0030225 10 6 0,000 0,04314063 0,12219636 ! astrocyte development GO:0014002 14 6 0,000 0,04314063 0,12204606 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04314063 0,12189613 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04314063 0,12174656 ! interaction with symbiont GO:0051702 8 6 0,000 0,04314063 0,12159736 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04314063 0,12144853 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04314063 0,12130006 ! eating behavior GO:0042755 6 6 0,000 0,04314063 0,12115195 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04314063 0,1210042 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04314063 0,12085682 ! response to copper ion GO:0046688 9 6 0,000 0,04314063 0,12070979 ! DNA topological change GO:0006265 8 6 0,000 0,04314063 0,12056312 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04314063 0,12041681 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04314063 0,12027085 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04314063 0,12012524 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04314063 0,11997999 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04314063 0,11983508 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04314063 0,11969053 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04314063 0,11954632 ! gas homeostasis GO:0033483 11 6 0,000 0,04314063 0,11940246 ! hair follicle maturation GO:0048820 7 6 0,000 0,04314063 0,11925895 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04314063 0,11911578 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04314063 0,11897296 ! Schwann cell development GO:0014044 14 6 0,000 0,04314063 0,11883048 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04314063 0,11868833 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04314063 0,11854653 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04314063 0,11840507 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04314063 0,11826394 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04314063 0,11812315 ! histone ubiquitination GO:0016574 7 6 0,000 0,04314063 0,1179827 ! regulation of meiosis GO:0040020 10 6 0,000 0,04314063 0,11784257 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04314063 0,11770279 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04314063 0,11756333 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04314063 0,1174242 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04314063 0,1172854 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04314063 0,11714693 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04314063 0,11700878 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04314063 0,11687096 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04314063 0,11673347 ! receptor internalization GO:0031623 9 6 0,000 0,04314063 0,1165963 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04314063 0,11645945 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04314063 0,11632292 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04314063 0,11618671 ! protein deubiquitination GO:0016579 8 6 0,000 0,04314063 0,11605082 GO:0070646|protein modification by small protein removal, ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04314063 0,11591524 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04314063 0,11577999 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04314063 0,11564504 ! midbrain development GO:0030901 6 6 0,000 0,04314063 0,11551042 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04314063 0,1153761 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04314063 0,1152421 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04314063 0,11510841 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04314063 0,11497503 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04314063 0,11484195 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04314063 0,11470919 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04314063 0,11457673 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04314063 0,11444458 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04314063 0,11431273 ! adult feeding behavior GO:0008343 6 6 0,000 0,04314063 0,11418118 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04314063 0,11404994 ! pigment granule transport GO:0051904 12 6 0,000 0,04314063 0,113919 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04314063 0,11378836 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04314063 0,11365802 ! catecholamine transport GO:0051937 7 6 0,000 0,04314063 0,11352797 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04314063 0,11339823 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04314063 0,11326878 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04314063 0,11313962 ! protein prenylation GO:0018342 10 6 0,000 0,04314063 0,11301076 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04314063 0,11288219 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04314063 0,11275392 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04314063 0,11262593 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04314063 0,11249824 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04465591 0,11631778 ! regulation of ossification GO:0030278 71 46 1,000 0,04465591 0,1161862 ! viral infectious cycle GO:0019058 71 47 1,000 0,04642217 0,12064518 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 1,000 0,04821377 0,12515991 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 1,000 0,04821377 0,1250188 ! nuclear export GO:0051168 69 48 1,000 0,04821377 0,12487802 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,04821377 0,12473755 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,04821377 0,12459739 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,05003028 0,12914661 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,05003028 0,12900183 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,05003028 0,12885737 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,05014898 0,12901864 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05014898 0,12887448 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05014898 0,12873065 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05014898 0,12858714 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05014898 0,12844395 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05014898 0,12830107 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05014898 0,12815851 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05014898 0,12801627 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05014898 0,12787435 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,05014898 0,12773274 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05014898 0,12759144 ! reproductive behavior GO:0019098 12 7 0,000 0,05014898 0,12745046 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05014898 0,12730978 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05014898 0,12716942 ! oligopeptide transport GO:0006857 11 7 0,000 0,05014898 0,12702936 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05014898 0,12688962 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05014898 0,12675018 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05014898 0,12661105 ! RNA methylation GO:0001510 11 7 0,000 0,05014898 0,12647222 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05014898 0,12633369 ! fibril organization GO:0043206 13 7 0,000 0,05014898 0,12619547 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05014898 0,12605756 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05014898 0,12591994 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05014898 0,12578262 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05014898 0,1256456 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05014898 0,12550888 ! estrogen metabolic process GO:0008210 14 7 0,000 0,05014898 0,12537246 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05014898 0,12523633 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05014898 0,1251005 ! chemosensory behavior GO:0007635 9 7 0,000 0,05014898 0,12496497 ! microtubule bundle formation GO:0001578 8 7 0,000 0,05014898 0,12482972 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05014898 0,12469477 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05014898 0,12456011 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05014898 0,12442574 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05014898 0,12429166 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05014898 0,12415787 ! reflex GO:0060004 12 7 0,000 0,05014898 0,12402437 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05014898 0,12389115 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,05014898 0,12375822 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05014898 0,12362558 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05014898 0,12349322 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,05014898 0,12336114 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05014898 0,12322934 ! spinal cord patterning GO:0021511 7 7 0,000 0,05014898 0,12309783 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05014898 0,12296659 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05014898 0,12283564 ! adrenal gland development GO:0030325 17 7 0,000 0,05014898 0,12270496 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05014898 0,12257456 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05014898 0,12244444 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05014898 0,12231459 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05014898 0,12218502 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05014898 0,12205573 ! endosome organization GO:0007032 10 7 0,000 0,05014898 0,1219267 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05014898 0,12179795 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05014898 0,12166948 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05014898 0,12154127 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,05014898 0,12141333 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,05014898 0,12128566 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05014898 0,12115826 ! galactose metabolic process GO:0006012 10 7 0,000 0,05014898 0,12103113 ! vesicle fusion GO:0006906 15 7 0,000 0,05014898 0,12090426 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05014898 0,12077766 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05014898 0,12065132 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05014898 0,12052525 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05014898 0,12039944 ! retinol metabolic process GO:0042572 9 7 0,000 0,05014898 0,12027389 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05014898 0,12014861 ! rRNA modification GO:0000154 12 7 0,000 0,05014898 0,12002358 ! protein heterooligomerization GO:0051291 10 7 0,000 0,05014898 0,11989882 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05014898 0,11977431 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05014898 0,11965007 ! intermediate filament organization GO:0045109 11 7 0,000 0,05014898 0,11952608 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05014898 0,11940234 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05014898 0,11927887 ! fibrinolysis GO:0042730 9 7 0,000 0,05014898 0,11915564 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,05014898 0,11903268 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05014898 0,11890996 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05014898 0,1187875 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05014898 0,11866529 ! response to tropane GO:0014073 13 7 0,000 0,05014898 0,11854333 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05014898 0,11842163 ! melanosome localization GO:0032400 10 7 0,000 0,05014898 0,11830017 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05014898 0,11817896 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05014898 0,118058 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05014898 0,11793728 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05014898 0,11781682 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05014898 0,11769659 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05014898 0,11757662 ! mast cell activation GO:0045576 9 7 0,000 0,05014898 0,11745689 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05014898 0,1173374 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05014898 0,11721815 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05014898 0,11709915 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05014898 0,11698039 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05014898 0,11686187 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05014898 0,11674359 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05014898 0,11662554 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05014898 0,11650774 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05014898 0,11639017 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05014898 0,11627285 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05014898 0,11615575 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05014898 0,1160389 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05014898 0,11592227 ! diuresis GO:0030146 12 7 0,000 0,05014898 0,11580589 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05014898 0,11568973 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05014898 0,11557381 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05014898 0,11545812 ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05014898 0,11534266 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05014898 0,11522744 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05014898 0,11511244 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05014898 0,11499767 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05014898 0,11488313 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05014898 0,11476882 ! lymph node development GO:0048535 9 7 0,000 0,05014898 0,11465473 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05014898 0,11454088 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05014898 0,11442724 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05014898 0,11431384 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05014898 0,11420066 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05014898 0,1140877 ! ATP catabolic process GO:0006200 10 7 0,000 0,05014898 0,11397496 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05014898 0,11386245 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05014898 0,11375016 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05014898 0,11363809 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05014898 0,11352624 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05014898 0,11341461 ! muscle adaptation GO:0043500 12 7 0,000 0,05014898 0,11330321 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05014898 0,11319201 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05014898 0,11308104 ! retina homeostasis GO:0001895 9 7 0,000 0,05014898 0,11297029 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,05014898 0,11285975 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05014898 0,11274943 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05014898 0,11263932 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05014898 0,11252943 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05014898 0,11241975 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05014898 0,11231029 ! regulation of actin filament length GO:0030832 72 50 1,000 0,05187122 0,11605428 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05187122 0,1159415 ! membrane fusion GO:0006944 80 50 1,000 0,05187122 0,11582893 ! muscle fiber development GO:0048747 74 51 1,000 0,05373615 0,11987697 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,05373615 0,11976081 ! regulation of cellular component size GO:0032535 74 52 1,000 0,05562464 0,12384963 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,0571064 0,12702585 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,0571064 0,12690312 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,0571064 0,12678063 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,0571064 0,12665837 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,0571064 0,12653635 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,0571064 0,12641456 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,0571064 0,12629301 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,0571064 0,12617169 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,0571064 0,12605061 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,0571064 0,12592975 ! phosphate transport GO:0006817 10 8 0,000 0,0571064 0,12580913 ! N-glycan processing GO:0006491 12 8 0,000 0,0571064 0,12568874 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,0571064 0,12556858 ! UTP metabolic process GO:0046051 8 8 0,000 0,0571064 0,12544864 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,0571064 0,12532894 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,0571064 0,12520947 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,0571064 0,12509022 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,0571064 0,1249712 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,0571064 0,12485241 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,0571064 0,12473384 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,0571064 0,12461549 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,0571064 0,12449738 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,0571064 0,12437948 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,0571064 0,12426181 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,0571064 0,12414436 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,0571064 0,12402713 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,0571064 0,12391012 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,0571064 0,12379334 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,0571064 0,12367677 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,0571064 0,12356042 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,0571064 0,1234443 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,0571064 0,12332839 ! astrocyte differentiation GO:0048708 16 8 0,000 0,0571064 0,12321269 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,0571064 0,12309722 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,0571064 0,12298196 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,0571064 0,12286691 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,0571064 0,12275209 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,0571064 0,12263747 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,0571064 0,12252307 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,0571064 0,12240888 ! macrophage activation GO:0042116 12 8 0,000 0,0571064 0,12229491 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,0571064 0,12218115 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,0571064 0,12206759 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,0571064 0,12195425 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,0571064 0,12184112 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,0571064 0,1217282 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,0571064 0,12161549 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,0571064 0,12150299 ! ruffle organization GO:0031529 11 8 0,000 0,0571064 0,12139069 ! osteoblast development GO:0002076 13 8 0,000 0,0571064 0,12127861 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,0571064 0,12116673 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,0571064 0,12105505 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,0571064 0,12094358 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,0571064 0,12083232 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,0571064 0,12072126 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,0571064 0,1206104 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,0571064 0,12049975 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,0571064 0,1203893 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,0571064 0,12027906 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,0571064 0,12016901 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,0571064 0,12005917 ! oligodendrocyte development GO:0014003 8 8 0,000 0,0571064 0,11994953 ! segment specification GO:0007379 10 8 0,000 0,0571064 0,11984008 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,0571064 0,11973084 ! cellular extravasation GO:0045123 11 8 0,000 0,0571064 0,1196218 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,0571064 0,11951295 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,0571064 0,1194043 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,0571064 0,11929585 ! snRNA metabolic process GO:0016073 10 8 0,000 0,0571064 0,1191876 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,0571064 0,11907954 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,0571064 0,11897168 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,0571064 0,11886401 ! nucleosome disassembly GO:0006337 12 8 0,000 0,0571064 0,11875654 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,0571064 0,11864926 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,0571064 0,11854218 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,0571064 0,11843528 ! icosanoid secretion GO:0032309 12 8 0,000 0,0571064 0,11832859 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,0571064 0,11822208 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,0571064 0,11811577 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,0571064 0,11800964 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,0571064 0,11790371 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,0571064 0,11779796 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,0571064 0,11769241 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,0571064 0,11758705 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,0571064 0,11748187 ! sterol catabolic process GO:0016127 9 8 0,000 0,0571064 0,11737688 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,0571064 0,11727208 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,0571064 0,11716747 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,0571064 0,11706304 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,0571064 0,1169588 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,0571064 0,11685474 ! prophase GO:0051324 11 8 0,000 0,0571064 0,11675087 ! S phase GO:0051320 8 8 0,000 0,0571064 0,11664719 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,0571064 0,11654368 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,0571064 0,11644036 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,0571064 0,11633723 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,0571064 0,11623428 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,0571064 0,1161315 ! hormone catabolic process GO:0042447 13 8 0,000 0,0571064 0,11602891 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,0571064 0,11592651 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,0571064 0,11582428 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,0571064 0,11572223 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,0571064 0,11562036 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,0571064 0,11551867 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,0571064 0,11541716 ! lamellipodium assembly GO:0030032 9 8 0,000 0,0571064 0,11531583 ! regulation of embryonic development GO:0045995 16 8 0,000 0,0571064 0,11521468 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,0571064 0,1151137 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,0571064 0,1150129 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,0571064 0,11491228 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,05753623 0,11567599 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,05753623 0,11557496 ! single fertilization GO:0007338 59 53 1,000 0,05753623 0,11547411 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,0594705 0,1192521 ! detection of external stimulus GO:0009581 66 54 1,000 0,0594705 0,11914822 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,0594705 0,11904452 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,06340536 0,12681072 ! negative regulation of response to stimulus GO:0048585 80 56 1,000 0,06340536 0,12670055 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06401326 0,12780425 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06401326 0,12769341 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06401326 0,12758275 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06401326 0,12747229 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06401326 0,12736202 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06401326 0,12725194 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06401326 0,12714205 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06401326 0,12703235 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06401326 0,12692284 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06401326 0,12681352 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06401326 0,12670439 ! GTP metabolic process GO:0046039 9 9 0,000 0,06401326 0,12659544 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06401326 0,12648668 ! social behavior GO:0035176 14 9 0,000 0,06401326 0,12637811 ! artery development GO:0060840 19 9 0,000 0,06401326 0,12626972 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06401326 0,12616152 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06401326 0,12605351 ! response to pain GO:0048265 16 9 0,000 0,06401326 0,12594568 ! protein complex disassembly GO:0043241 17 9 0,000 0,06401326 0,12583803 GO:0043624|cellular protein complex disassembly, ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06401326 0,12573057 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06401326 0,12562329 ! lung alveolus development GO:0048286 17 9 0,000 0,06401326 0,1255162 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06401326 0,12540928 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06401326 0,12530255 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06401326 0,125196 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06401326 0,12508963 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06401326 0,12498344 ! protein targeting to ER GO:0045047 19 9 0,000 0,06401326 0,12487744 ! endoderm development GO:0007492 12 9 0,000 0,06401326 0,12477161 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06401326 0,12466596 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06401326 0,12456049 ! arginine catabolic process GO:0006527 10 9 0,000 0,06401326 0,1244552 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06401326 0,12435008 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06401326 0,12424515 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06401326 0,12414039 ! V(D)J recombination GO:0033151 12 9 0,000 0,06401326 0,1240358 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06401326 0,12393139 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06401326 0,12382716 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06401326 0,12372311 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06401326 0,12361922 ! mannose metabolic process GO:0006013 9 9 0,000 0,06401326 0,12351552 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06401326 0,12341198 ! receptor clustering GO:0043113 15 9 0,000 0,06401326 0,12330862 ! epithelial cell development GO:0002064 10 9 0,000 0,06401326 0,12320544 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06401326 0,12310242 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06401326 0,12299958 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06401326 0,12289691 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06401326 0,12279441 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06401326 0,12269208 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06401326 0,12258992 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06401326 0,12248793 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,06401326 0,12238612 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06401326 0,12228447 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06401326 0,12218298 ! DNA ligation GO:0006266 14 9 0,000 0,06401326 0,12208167 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06401326 0,12198053 ! response to amine stimulus GO:0014075 13 9 0,000 0,06401326 0,12187955 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06401326 0,12177874 ! erythrocyte development GO:0048821 11 9 0,000 0,06401326 0,1216781 ! renal water homeostasis GO:0003091 14 9 0,000 0,06401326 0,12157762 ! postreplication repair GO:0006301 11 9 0,000 0,06401326 0,12147731 ! mRNA cleavage GO:0006379 13 9 0,000 0,06401326 0,12137716 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06401326 0,12127718 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06401326 0,12117736 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06401326 0,12107771 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06401326 0,12097822 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06401326 0,1208789 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06401326 0,12077973 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06401326 0,12068074 ! acid secretion GO:0046717 14 9 0,000 0,06401326 0,1205819 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06401326 0,12048322 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06401326 0,12038471 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06401326 0,12028635 ! purine base metabolic process GO:0006144 18 9 0,000 0,06401326 0,12018816 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06401326 0,12009013 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06401326 0,11999226 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06401326 0,11989454 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06401326 0,11979699 ! detection of calcium ion GO:0005513 13 9 0,000 0,06401326 0,11969959 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06401326 0,11960235 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06401326 0,11950527 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06401326 0,11940835 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06401326 0,11931159 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06401326 0,11921498 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06401326 0,11911853 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06401326 0,11902223 ! prepulse inhibition GO:0060134 14 9 0,000 0,06401326 0,11892609 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06401326 0,1188301 ! insulin secretion GO:0030073 17 9 0,000 0,06401326 0,11873427 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06401326 0,1186386 ! nucleus localization GO:0051647 15 9 0,000 0,06401326 0,11854307 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06401326 0,1184477 ! localization within membrane GO:0051668 15 9 0,000 0,06401326 0,11835249 ! carbohydrate transport GO:0008643 74 57 1,000 0,06540511 0,12082871 ! camera-type eye development GO:0043010 88 57 1,000 0,06540511 0,12073174 ! secondary metabolic process GO:0019748 84 57 1,000 0,06540511 0,12063492 ! developmental maturation GO:0021700 75 57 1,000 0,06540511 0,12053826 ! viral reproductive process GO:0022415 87 58 1,000 0,06742585 0,12416289 ! lung development GO:0030324 94 59 1,000 0,06946717 0,12781958 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,07086991 0,1302964 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,07086991 0,13019233 ! neuron fate specification GO:0048665 11 10 0,000 0,07086991 0,13008843 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,07086991 0,12998469 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,07086991 0,12988112 ! thyroid gland development GO:0030878 19 10 0,000 0,07086991 0,12977771 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,07086991 0,12967446 ! synapsis GO:0007129 13 10 0,000 0,07086991 0,12957138 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,07086991 0,12946847 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,07086991 0,12936571 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,07086991 0,12926312 GO:0007520|myoblast fusion, ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,07086991 0,1291607 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,07086991 0,12905843 ! androgen metabolic process GO:0008209 13 10 0,000 0,07086991 0,12895633 ! phospholipid efflux GO:0033700 16 10 0,000 0,07086991 0,12885439 ! hippocampus development GO:0021766 19 10 0,000 0,07086991 0,12875261 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,07086991 0,12865099 ! blood vessel remodeling GO:0001974 21 10 0,000 0,07086991 0,12854953 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,07086991 0,12844823 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,07086991 0,12834709 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,07086991 0,12824611 ! pathogenesis GO:0009405 13 10 0,000 0,07086991 0,12814528 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,07086991 0,12804462 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,07086991 0,12794411 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,07086991 0,12784376 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,07086991 0,12774357 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,07086991 0,12764354 ! melanocyte differentiation GO:0030318 15 10 0,000 0,07086991 0,12754366 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,07086991 0,12744394 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,07086991 0,12734437 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,07086991 0,12724496 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,07086991 0,12714571 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,07086991 0,12704661 ! forebrain cell migration GO:0021885 17 10 0,000 0,07086991 0,12694766 ! lipid digestion GO:0044241 15 10 0,000 0,07086991 0,12684887 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,07086991 0,12675023 ! UV protection GO:0009650 14 10 0,000 0,07086991 0,12665175 ! entry into host cell GO:0030260 20 10 0,000 0,07086991 0,12655342 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,07086991 0,12645524 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,07086991 0,12635721 ! regulation of bone resorption GO:0045124 24 10 0,000 0,07086991 0,12625933 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,07086991 0,12616161 ! regulation of organ growth GO:0046620 11 10 0,000 0,07086991 0,12606404 ! response to dsRNA GO:0043331 18 10 0,000 0,07086991 0,12596661 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,07086991 0,12586934 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,07086991 0,12577222 ! embryonic axis specification GO:0000578 12 10 0,000 0,07086991 0,12567525 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,07086991 0,12557843 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,07086991 0,12548175 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,07086991 0,12538523 ! cranial nerve development GO:0021545 12 10 0,000 0,07086991 0,12528885 ! fucose catabolic process GO:0019317 16 10 0,000 0,07086991 0,12519263 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,07086991 0,12509655 ! protein sumoylation GO:0016925 12 10 0,000 0,07086991 0,12500061 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,07086991 0,12490483 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,07086991 0,12480919 ! zymogen activation GO:0031638 14 10 0,000 0,07086991 0,1247137 ! salivary gland development GO:0007431 22 10 0,000 0,07086991 0,12461835 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,07086991 0,12452315 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,07086991 0,12442809 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,07086991 0,12433318 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,07086991 0,12423841 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,07086991 0,12414379 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,07086991 0,12404931 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,07086991 0,12395498 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,07086991 0,12386079 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,07086991 0,12376674 ! detection of bacterium GO:0016045 10 10 0,000 0,07086991 0,12367284 ! embryonic gut development GO:0048566 11 10 0,000 0,07086991 0,12357907 ! activation of innate immune response GO:0002218 10 10 0,000 0,07086991 0,12348545 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,07086991 0,12339198 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,07086991 0,12329864 ! developmental induction GO:0031128 13 10 0,000 0,07086991 0,12320544 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,07086991 0,12311239 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,07086991 0,12301947 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,07086991 0,1229267 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,07086991 0,12283406 ! embryonic limb morphogenesis GO:0030326 86 60 1,000 0,07152866 0,12388248 GO:0035113|embryonic appendage morphogenesis, ! fertilization GO:0009566 68 60 1,000 0,07152866 0,12378926 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,07360994 0,12729539 ! extracellular matrix organization GO:0030198 103 61 1,000 0,07360994 0,12719975 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,07360994 0,12710425 ! respiratory tube development GO:0030323 99 62 1,000 0,0757106 0,13063345 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,0757106 0,13053552 ! rRNA transcription GO:0009303 17 11 0,000 0,07767673 0,13382507 ! respiratory burst GO:0045730 14 11 0,000 0,07767673 0,1337249 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07767673 0,13362489 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07767673 0,13352502 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07767673 0,1334253 ! virus-host interaction GO:0019048 17 11 0,000 0,07767673 0,13332572 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,07767673 0,1332263 ! filopodium assembly GO:0046847 19 11 0,000 0,07767673 0,13312703 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07767673 0,1330279 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07767673 0,13292892 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,07767673 0,13283009 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,07767673 0,13273141 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,07767673 0,13263287 ! T cell proliferation GO:0042098 20 11 0,000 0,07767673 0,13253447 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07767673 0,13243623 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,07767673 0,13233813 ! bone resorption GO:0045453 16 11 0,000 0,07767673 0,13224017 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07767673 0,13214236 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07767673 0,13204469 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07767673 0,13194717 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,07767673 0,13184979 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07767673 0,13175256 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07767673 0,13165547 ! syncytium formation GO:0006949 15 11 0,000 0,07767673 0,13155852 ! plasma membrane organization GO:0007009 18 11 0,000 0,07767673 0,13146172 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07767673 0,13136505 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07767673 0,13126853 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07767673 0,13117215 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07767673 0,13107591 ! adult heart development GO:0007512 11 11 0,000 0,07767673 0,13097982 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,07767673 0,13088386 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,07767673 0,13078805 ! temperature homeostasis GO:0001659 16 11 0,000 0,07767673 0,13069237 ! L-glutamate transport GO:0015813 16 11 0,000 0,07767673 0,13059684 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07767673 0,13050144 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07767673 0,13040618 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07767673 0,13031107 ! stem cell development GO:0048864 29 11 0,000 0,07767673 0,13021609 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07767673 0,13012125 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07767673 0,13002654 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07767673 0,12993198 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,07767673 0,12983755 ! vasoconstriction GO:0042310 15 11 0,000 0,07767673 0,12974326 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,07767673 0,12964911 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07767673 0,12955509 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07767673 0,12946121 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07767673 0,12936747 ! ribosome assembly GO:0042255 13 11 0,000 0,07767673 0,12927386 ! histone deacetylation GO:0016575 13 11 0,000 0,07767673 0,12918038 ! chromatin silencing GO:0006342 19 11 0,000 0,07767673 0,12908705 ! nucleosome positioning GO:0016584 13 11 0,000 0,07767673 0,12899384 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07767673 0,12890077 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07767673 0,12880784 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07767673 0,12871504 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07767673 0,12862237 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07767673 0,12852984 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07767673 0,12843743 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07767673 0,12834517 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07767673 0,12825303 ! cholesterol efflux GO:0033344 19 11 0,000 0,07767673 0,12816103 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07767673 0,12806916 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07767673 0,12797741 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,07767673 0,12788581 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,07767673 0,12779433 ! defense response to fungus GO:0050832 12 11 0,000 0,07767673 0,12770298 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07767673 0,12761177 ! lysogeny GO:0030069 18 11 0,000 0,07767673 0,12752068 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07767673 0,12742972 ! acrosome reaction GO:0007340 13 11 0,000 0,07767673 0,1273389 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07767673 0,1272482 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,07783026 0,12740896 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,07783026 0,12731834 ! viral reproduction GO:0016032 92 63 1,000 0,07783026 0,12722785 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,07996852 0,1306304 ! appendage morphogenesis GO:0035107 93 64 1,000 0,07996852 0,13053768 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,07996852 0,1304451 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 1,000 0,07996852 0,13035266 ! respiratory system development GO:0060541 100 64 1,000 0,07996852 0,13026034 ! appendage development GO:0048736 94 65 1,000 0,08212501 0,13367836 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,08212501 0,13358382 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,08212501 0,13348942 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,08429935 0,13692691 ! lactation GO:0007595 20 12 0,000 0,08443406 0,13704893 ! reproductive cellular process GO:0048610 14 12 0,000 0,08443406 0,13695228 ! tRNA modification GO:0006400 14 12 0,000 0,08443406 0,13685577 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08443406 0,13675939 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08443406 0,13666315 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,08443406 0,13656705 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08443406 0,13647107 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08443406 0,13637524 ! non-recombinational repair GO:0000726 19 12 0,000 0,08443406 0,13627954 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08443406 0,13618397 ! peroxisomal transport GO:0043574 21 12 0,000 0,08443406 0,13608853 ! cartilage condensation GO:0001502 18 12 0,000 0,08443406 0,13599323 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08443406 0,13589807 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08443406 0,13580303 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08443406 0,13570813 ! heart looping GO:0001947 15 12 0,000 0,08443406 0,13561337 ! palate development GO:0060021 15 12 0,000 0,08443406 0,13551873 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08443406 0,13542423 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08443406 0,13532985 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08443406 0,13523561 ! arginine metabolic process GO:0006525 13 12 0,000 0,08443406 0,1351415 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08443406 0,13504752 ! methionine metabolic process GO:0006555 13 12 0,000 0,08443406 0,13495368 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,08443406 0,13485996 ! Golgi organization GO:0007030 18 12 0,000 0,08443406 0,13476637 ! monoamine transport GO:0015844 13 12 0,000 0,08443406 0,13467291 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08443406 0,13457958 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,08443406 0,13448638 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08443406 0,13439331 ! L-amino acid transport GO:0015807 20 12 0,000 0,08443406 0,13430037 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08443406 0,13420756 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08443406 0,13411488 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08443406 0,13402232 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08443406 0,13392989 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08443406 0,13383759 ! cerebellum development GO:0021549 13 12 0,000 0,08443406 0,13374541 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08443406 0,13365336 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08443406 0,13356144 ! histone acetylation GO:0016573 23 12 0,000 0,08443406 0,13346965 ! histone methylation GO:0016571 15 12 0,000 0,08443406 0,13337798 ! autonomic nervous system development GO:0048483 23 12 0,000 0,08443406 0,13328644 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08443406 0,13319502 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,08443406 0,13310373 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08443406 0,13301256 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08443406 0,13292152 ! intestinal absorption GO:0050892 19 12 0,000 0,08443406 0,1328306 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08443406 0,13273981 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08443406 0,13264914 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08443406 0,13255859 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08443406 0,13246817 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08443406 0,13237787 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08443406 0,1322877 ! microspike assembly GO:0030035 23 12 0,000 0,08443406 0,13219764 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08443406 0,13210771 ! response to cold GO:0009409 14 12 0,000 0,08443406 0,13201791 ! learning or memory GO:0007611 123 68 1,000 0,0887001 0,13859391 ! rhythmic process GO:0048511 105 68 1,000 0,0887001 0,13849982 ! inorganic anion transport GO:0015698 93 68 1,000 0,0887001 0,13840586 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,09092578 0,14178257 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,09092578 0,14168651 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,09114227 0,14192771 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,09114227 0,14183168 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,09114227 0,14173578 ! cGMP metabolic process GO:0046068 16 13 0,000 0,09114227 0,14164002 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,09114227 0,14154438 ! water transport GO:0006833 17 13 0,000 0,09114227 0,14144887 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,09114227 0,14135349 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,09114227 0,14125824 ! lipid localization GO:0010876 24 13 0,000 0,09114227 0,14116311 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,09114227 0,14106812 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,09114227 0,14097325 ! organelle fusion GO:0048284 28 13 0,000 0,09114227 0,14087851 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,09114227 0,1407839 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,09114227 0,14068941 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,09114227 0,14059505 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,09114227 0,14050082 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,09114227 0,14040671 ! glutamate metabolic process GO:0006536 18 13 0,000 0,09114227 0,14031273 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,09114227 0,14021888 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,09114227 0,14012515 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,09114227 0,14003155 ! NAD metabolic process GO:0019674 21 13 0,000 0,09114227 0,13993807 ! exocrine system development GO:0035272 27 13 0,000 0,09114227 0,13984471 ! bone mineralization GO:0030282 15 13 0,000 0,09114227 0,13975148 ! regulation of exocytosis GO:0017157 17 13 0,000 0,09114227 0,13965838 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,09114227 0,1395654 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,09114227 0,13947254 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,09114227 0,1393798 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,09114227 0,13928719 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,09114227 0,1391947 ! tissue regeneration GO:0042246 21 13 0,000 0,09114227 0,13910234 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,09114227 0,1390101 ! cofactor transport GO:0051181 19 13 0,000 0,09114227 0,13891797 ! NADP metabolic process GO:0006739 18 13 0,000 0,09114227 0,13882598 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,09114227 0,1387341 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,09114227 0,13864234 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,09114227 0,13855071 ! gas transport GO:0015669 18 13 0,000 0,09114227 0,1384592 ! regulation of RNA stability GO:0043487 28 13 0,000 0,09114227 0,1383678 ! heme biosynthetic process GO:0006783 20 13 0,000 0,09114227 0,13827653 ! regulation of axon extension GO:0030516 23 13 0,000 0,09114227 0,13818538 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,09114227 0,13809435 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,09114227 0,13800344 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,09114227 0,13791265 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,09114227 0,13782197 ! humoral immune response GO:0006959 86 70 1,000 0,09316785 0,14079241 ! eye development GO:0001654 111 70 1,000 0,09316785 0,14069997 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,09542595 0,14401554 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,09542595 0,1439211 ! superoxide anion generation GO:0042554 18 14 0,000 0,09780171 0,14740756 ! neuron maturation GO:0042551 21 14 0,000 0,09780171 0,14731103 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09780171 0,14721462 ! myotube differentiation GO:0014902 21 14 0,000 0,09780171 0,14711834 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,09780171 0,14702218 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09780171 0,14692615 ! inositol metabolic process GO:0006020 20 14 0,000 0,09780171 0,14683025 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09780171 0,14673447 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09780171 0,14663881 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09780171 0,14654328 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09780171 0,14644788 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09780171 0,1463526 ! response to cAMP GO:0051591 19 14 0,000 0,09780171 0,14625744 ! limbic system development GO:0021761 25 14 0,000 0,09780171 0,1461624 ! startle response GO:0001964 21 14 0,000 0,09780171 0,14606749 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09780171 0,14597271 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,09780171 0,14587804 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09780171 0,1457835 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09780171 0,14568908 ! glycine metabolic process GO:0006544 22 14 0,000 0,09780171 0,14559478 ! pituitary gland development GO:0021983 23 14 0,000 0,09780171 0,14550061 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,09780171 0,14540655 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,09780171 0,14531262 ! regulation of heart rate GO:0002027 23 14 0,000 0,09780171 0,14521881 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09780171 0,14512512 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09780171 0,14503155 ! embryo implantation GO:0007566 27 14 0,000 0,09780171 0,14493811 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09780171 0,14484478 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09780171 0,14475157 ! axon cargo transport GO:0008088 27 14 0,000 0,09780171 0,14465848 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09780171 0,14456551 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09780171 0,14447267 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09780171 0,14437994 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09780171 0,14428733 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09780171 0,14419483 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09780171 0,14410246 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09780171 0,1440102 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09780171 0,14391807 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09780171 0,14382605 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,09780171 0,14373415 ! muscle maintenance GO:0046716 19 14 0,000 0,09780171 0,14364236 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09780171 0,1435507 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09780171 0,14345915 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09780171 0,14336771 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,09780171 0,14327639 ! cell killing GO:0001906 20 14 0,000 0,09780171 0,14318519 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,09780171 0,14309411 ! cilium assembly GO:0042384 20 14 0,000 0,09780171 0,14300314 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09780171 0,14291229 ! protein import into nucleus GO:0006606 118 74 1,000 0,10229297 0,14938022 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10441274 0,152379 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10441274 0,15228237 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10441274 0,15218587 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10441274 0,15208948 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,10441274 0,15199323 ! skin development GO:0043588 25 15 0,000 0,10441274 0,15189709 ! lipid phosphorylation GO:0046834 23 15 0,000 0,10441274 0,15180107 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10441274 0,15170518 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10441274 0,1516094 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10441274 0,15151375 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10441274 0,15141822 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10441274 0,15132281 ! adult walking behavior GO:0007628 25 15 0,000 0,10441274 0,15122752 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10441274 0,15113235 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10441274 0,15103729 ! myoblast differentiation GO:0045445 27 15 0,000 0,10441274 0,15094236 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10441274 0,15084755 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10441274 0,15075285 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10441274 0,15065828 ! cerebral cortex development GO:0021987 29 15 0,000 0,10441274 0,15056382 ! response to osmotic stress GO:0006970 22 15 0,000 0,10441274 0,15046948 ! vesicle coating GO:0006901 25 15 0,000 0,10441274 0,15037526 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,10441274 0,15028116 ! DNA integration GO:0015074 22 15 0,000 0,10441274 0,15018718 ! peptide secretion GO:0002790 27 15 0,000 0,10441274 0,15009331 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10441274 0,14999956 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10441274 0,14990593 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10441274 0,14981241 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10441274 0,14971901 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,10441274 0,14962573 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10441274 0,14953256 ! biomineral formation GO:0031214 18 15 0,000 0,10441274 0,14943951 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10441274 0,14934658 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10441274 0,14925376 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10441274 0,14916105 ! dopamine metabolic process GO:0042417 30 15 0,000 0,10441274 0,14906846 ! organic cation transport GO:0015695 19 15 0,000 0,10441274 0,14897599 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10441274 0,14888363 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10441274 0,14879139 ! peptide hormone processing GO:0016486 19 15 0,000 0,10441274 0,14869925 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,10441274 0,14860724 ! regulation of ligase activity GO:0051340 114 75 1,000 0,10461175 0,14879841 ! nuclear import GO:0051170 121 75 1,000 0,10461175 0,14870644 ! regulation of protein transport GO:0051223 114 76 1,000 0,10694485 0,15192906 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 1,000 0,10929194 0,15516757 ! protein ubiquitination GO:0016567 125 77 1,000 0,10929194 0,15507185 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,10929194 0,15497624 ! protein secretion GO:0009306 27 16 0,000 0,11097569 0,15726685 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,11097569 0,15717001 ! hormone secretion GO:0046879 25 16 0,000 0,11097569 0,15707329 ! bone remodeling GO:0046849 24 16 0,000 0,11097569 0,15697669 ! endothelial cell migration GO:0043542 22 16 0,000 0,11097569 0,15688021 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,11097569 0,15678384 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,11097569 0,1566876 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,11097569 0,15659147 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,11097569 0,15649546 ! glial cell development GO:0021782 24 16 0,000 0,11097569 0,15639957 ! patterning of blood vessels GO:0001569 24 16 0,000 0,11097569 0,1563038 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,11097569 0,15620814 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,11097569 0,1561126 ! protein polyubiquitination GO:0000209 26 16 0,000 0,11097569 0,15601717 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,11097569 0,15592187 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,11097569 0,15582668 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,11097569 0,1557316 ! fructose metabolic process GO:0006000 20 16 0,000 0,11097569 0,15563664 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,11097569 0,1555418 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,11097569 0,15544708 ! protein export from nucleus GO:0006611 24 16 0,000 0,11097569 0,15535246 ! negative regulation of immune response GO:0050777 28 16 0,000 0,11097569 0,15525797 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,11097569 0,15516359 ! DNA replication initiation GO:0006270 25 16 0,000 0,11097569 0,15506932 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,11097569 0,15497517 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,11097569 0,15488113 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,11097569 0,1547872 ! diencephalon development GO:0021536 25 16 0,000 0,11097569 0,15469339 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,11097569 0,1545997 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,11097569 0,15450611 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,11097569 0,15441264 ! steroid catabolic process GO:0006706 22 16 0,000 0,11097569 0,15431929 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,11097569 0,15422604 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,11097569 0,15413291 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,11097569 0,15403989 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,11097569 0,15394698 ! sperm-egg recognition GO:0035036 16 16 0,000 0,11097569 0,15385419 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,11097569 0,1537615 ! nerve development GO:0021675 18 16 0,000 0,11097569 0,15366893 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,11097569 0,15357647 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,11097569 0,15348412 ! negative regulation of translation GO:0017148 22 16 0,000 0,11097569 0,15339189 ! positive regulation of protein modification process GO:0031401 107 78 1,000 0,1116527 0,15423496 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,11641394 0,16071553 GO:0010498|proteasomal protein catabolic process, ! forebrain development GO:0030900 131 80 1,000 0,11641394 0,16061912 ! protein localization in nucleus GO:0034504 133 80 1,000 0,11641394 0,16052282 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11749093 0,16191081 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11749093 0,16181386 ! negative regulation of defense response GO:0031348 19 17 0,000 0,11749093 0,16171702 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,11749093 0,1616203 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11749093 0,16152369 ! glycerol metabolic process GO:0006071 20 17 0,000 0,11749093 0,1614272 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11749093 0,16133083 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,11749093 0,16123457 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11749093 0,16113843 ! signal complex assembly GO:0007172 29 17 0,000 0,11749093 0,1610424 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,11749093 0,16094648 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,11749093 0,16085068 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,11749093 0,16075499 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11749093 0,16065942 ! memory GO:0007613 25 17 0,000 0,11749093 0,16056396 ! keratinization GO:0031424 17 17 0,000 0,11749093 0,16046861 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11749093 0,16037338 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11749093 0,16027826 ! retinoid metabolic process GO:0001523 22 17 0,000 0,11749093 0,16018325 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,11749093 0,16008835 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,11749093 0,15999357 ! vacuolar transport GO:0007034 24 17 0,000 0,11749093 0,1598989 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,11749093 0,15980434 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,11749093 0,15970989 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,11749093 0,15961556 ! membrane budding GO:0006900 29 17 0,000 0,11749093 0,15952133 ! heme metabolic process GO:0042168 27 17 0,000 0,11749093 0,15942722 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,11749093 0,15933322 ! body fluid secretion GO:0007589 27 17 0,000 0,11749093 0,15923933 ! stem cell differentiation GO:0048863 36 17 0,000 0,11749093 0,15914555 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,11749093 0,15905188 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,11749093 0,15895832 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11749093 0,15886487 ! sensory perception of pain GO:0019233 23 17 0,000 0,11749093 0,15877153 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11749093 0,1586783 GO:0002712|regulation of B cell mediated immunity, ! synaptogenesis GO:0007416 24 17 0,000 0,11749093 0,15858518 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11749093 0,15849216 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,11749093 0,15839926 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,11749093 0,15830647 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,11749093 0,15821378 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,11749093 0,15812121 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,11749093 0,15802874 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,11749093 0,15793638 ! response to protein stimulus GO:0051789 111 81 1,000 0,11881379 0,15962133 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,11881379 0,15952815 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 1,000 0,12122604 0,16267205 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,12395879 0,16624211 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12395879 0,16614523 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12395879 0,16604847 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,12395879 0,16595181 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12395879 0,16585527 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12395879 0,16575885 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12395879 0,16566253 ! axis specification GO:0009798 26 18 0,000 0,12395879 0,16556633 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12395879 0,16547024 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12395879 0,16537426 ! pancreas development GO:0031016 26 18 0,000 0,12395879 0,16527839 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12395879 0,16518263 ! response to retinoic acid GO:0032526 25 18 0,000 0,12395879 0,16508698 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12395879 0,16499144 ! fucose metabolic process GO:0006004 26 18 0,000 0,12395879 0,16489602 ! response to fungus GO:0009620 19 18 0,000 0,12395879 0,1648007 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12395879 0,1647055 ! heart process GO:0003015 27 18 0,000 0,12395879 0,1646104 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12395879 0,16451542 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,12395879 0,16442054 ! visual learning GO:0008542 35 18 0,000 0,12395879 0,16432577 ! somitogenesis GO:0001756 24 18 0,000 0,12395879 0,16423112 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12395879 0,16413657 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12395879 0,16404213 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12395879 0,1639478 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12395879 0,16385357 ! vitamin transport GO:0051180 24 18 0,000 0,12395879 0,16375946 ! hormone transport GO:0009914 27 18 0,000 0,12395879 0,16366545 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,12395879 0,16357155 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12395879 0,16347776 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12395879 0,16338408 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12395879 0,1632905 ! cell-cell recognition GO:0009988 20 18 0,000 0,12395879 0,16319703 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12395879 0,16310367 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12395879 0,16301042 ! regulation of glucose import GO:0046324 21 18 0,000 0,12395879 0,16291727 GO:0010827|regulation of glucose transport, ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,12395879 0,16282422 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,13037961 0,17116045 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,13037961 0,17106281 ! positive regulation of ossification GO:0045778 30 19 0,000 0,13037961 0,17096529 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,13037961 0,17086787 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,13037961 0,17077057 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,13037961 0,17067337 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,13037961 0,17057629 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,13037961 0,17047931 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,13037961 0,17038245 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,13037961 0,1702857 ! sensory perception of taste GO:0050909 23 19 0,000 0,13037961 0,17018905 ! smooth muscle contraction GO:0006939 36 19 0,000 0,13037961 0,17009252 ! peroxisome organization GO:0007031 29 19 0,000 0,13037961 0,1699961 ! digestive system process GO:0022600 30 19 0,000 0,13037961 0,16989978 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,13037961 0,16980357 ! response to vitamin A GO:0033189 26 19 0,000 0,13037961 0,16970748 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,13037961 0,16961149 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,13037961 0,16951561 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,13037961 0,16941984 ! cytolysis GO:0019835 20 19 0,000 0,13037961 0,16932417 ! vasodilation GO:0042311 33 19 0,000 0,13037961 0,16922862 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,13037961 0,16913317 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,13037961 0,16903783 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,13037961 0,1689426 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,13037961 0,16884747 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,13037961 0,16875245 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,13037961 0,16865754 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,13037961 0,16856274 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,13037961 0,16846804 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,13037961 0,16837345 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,13037961 0,16827896 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,13037961 0,16818458 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,13037961 0,16809031 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,13037961 0,16799614 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,13037961 0,16790208 ! protein stabilization GO:0050821 26 19 0,000 0,13037961 0,16780812 ! cellular defense response GO:0006968 102 87 1,000 0,13346276 0,17168029 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,13346276 0,17158433 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,13346276 0,17148847 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,13594313 0,174578 ! protein processing GO:0016485 114 88 1,000 0,13594313 0,17448058 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13675374 0,17542309 ! iron ion transport GO:0006826 37 20 0,000 0,13675374 0,17532531 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13675374 0,17522764 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13675374 0,17513007 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,13675374 0,17503261 ! response to vitamin GO:0033273 29 20 0,000 0,13675374 0,17493527 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13675374 0,17483803 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13675374 0,17474089 ! spinal cord development GO:0021510 31 20 0,000 0,13675374 0,17464387 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,13675374 0,17454695 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13675374 0,17445014 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,13675374 0,17435344 ! chromosome condensation GO:0030261 31 20 0,000 0,13675374 0,17425685 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13675374 0,17416036 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,13675374 0,17406398 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13675374 0,1739677 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13675374 0,17387154 ! pallium development GO:0021543 38 20 0,000 0,13675374 0,17377547 ! collagen fibril organization GO:0030199 45 20 0,000 0,13675374 0,17367952 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,13675374 0,17358367 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,13675374 0,17348793 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13675374 0,17339229 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,13675374 0,17329675 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,13675374 0,17320133 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,13675374 0,173106 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13675374 0,17301079 ! alditol metabolic process GO:0019400 24 20 0,000 0,13675374 0,17291567 ! actin filament-based movement GO:0030048 34 20 0,000 0,13675374 0,17282066 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,1409346 0,17800636 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,14308151 0,18061881 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,14308151 0,18051974 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,14308151 0,18042077 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14308151 0,18032191 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14308151 0,18022315 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,14308151 0,18012451 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14308151 0,18002597 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14308151 0,17992754 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14308151 0,17982922 ! protein amino acid acylation GO:0043543 37 21 0,000 0,14308151 0,17973101 ! vesicle docking GO:0048278 27 21 0,000 0,14308151 0,1796329 ! phototransduction GO:0007602 25 21 0,000 0,14308151 0,1795349 ! dendrite development GO:0016358 35 21 0,000 0,14308151 0,17943701 ! visual behavior GO:0007632 39 21 0,000 0,14308151 0,17933923 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,14308151 0,17924155 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14308151 0,17914397 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14308151 0,17904651 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14308151 0,17894915 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,14308151 0,17885189 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14308151 0,17875474 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,14308151 0,1786577 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,14308151 0,17856076 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14308151 0,17846393 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14308151 0,1783672 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,14308151 0,17827057 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14308151 0,17817405 ! immunoglobulin production GO:0002377 33 21 0,000 0,14308151 0,17807764 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14308151 0,17798133 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,14308151 0,17788512 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,14308151 0,17778902 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,14308151 0,17769302 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14308151 0,17759713 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14308151 0,17750134 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14308151 0,17740565 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14308151 0,17731006 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14308151 0,17721458 ! sulfur metabolic process GO:0006790 118 92 1,000 0,14596518 0,18068886 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,14849445 0,18372094 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,14936326 0,1846965 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,14936326 0,18459726 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,14936326 0,18449812 ! leukocyte adhesion GO:0007159 38 22 0,000 0,14936326 0,18439908 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,14936326 0,18430016 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,14936326 0,18420134 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,14936326 0,18410262 ! lysosome organization GO:0007040 37 22 0,000 0,14936326 0,18400401 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,14936326 0,18390551 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,14936326 0,18380711 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,14936326 0,18370882 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,14936326 0,18361063 ! membrane depolarization GO:0051899 35 22 0,000 0,14936326 0,18351255 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,14936326 0,18341457 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,14936326 0,1833167 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,14936326 0,18321893 ! neural tube closure GO:0001843 33 22 0,000 0,14936326 0,18312127 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,14936326 0,18302371 ! angiogenesis GO:0001525 149 95 1,000 0,15357963 0,18809007 ! carboxylic acid transport GO:0046942 147 95 1,000 0,15357963 0,18798997 GO:0015849|organic acid transport, ! neuron fate commitment GO:0048663 32 23 0,000 0,15559931 0,19036086 ! embryonic pattern specification GO:0009880 31 23 0,000 0,15559931 0,19025966 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15559931 0,19015857 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,15559931 0,19005758 ! vesicle targeting GO:0006903 32 23 0,000 0,15559931 0,1899567 ! osteoblast differentiation GO:0001649 40 23 0,000 0,15559931 0,18985593 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15559931 0,18975526 ! interaction with host GO:0051701 37 23 0,000 0,15559931 0,1896547 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,15559931 0,18955425 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,15559931 0,1894539 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,15559931 0,18935366 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,15559931 0,18925353 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15559931 0,1891535 ! cell fate determination GO:0001709 45 23 0,000 0,15559931 0,18905358 ! pentose metabolic process GO:0019321 31 23 0,000 0,15559931 0,18895376 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15559931 0,18885405 ! spermatid development GO:0007286 33 23 0,000 0,15559931 0,18875444 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,15559931 0,18865494 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,15559931 0,18855554 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15559931 0,18845625 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,15559931 0,18835706 ! telomere organization GO:0032200 32 23 0,000 0,15559931 0,18825798 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,15559931 0,188159 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,15559931 0,18806013 ! regulation of amine transport GO:0051952 38 23 0,000 0,15559931 0,18796135 ! liver development GO:0001889 40 23 0,000 0,15559931 0,18786269 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,15613501 0,18841056 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,15613501 0,18831176 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,15613501 0,18821307 ! protein maturation GO:0051604 129 96 1,000 0,15613501 0,18811448 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,16179 0,19482566 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,16179 0,19472371 ! initiation of viral infection GO:0019059 42 24 0,000 0,16179 0,19462187 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,16179 0,19452013 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,16179 0,1944185 ! superoxide metabolic process GO:0006801 32 24 0,000 0,16179 0,19431698 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,16179 0,19421556 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! fat cell differentiation GO:0045444 37 24 0,000 0,16179 0,19411425 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,16179 0,19401304 ! sperm motility GO:0030317 27 24 0,000 0,16179 0,19391194 ! vacuole organization GO:0007033 39 24 0,000 0,16179 0,19381094 ! receptor metabolic process GO:0043112 37 24 0,000 0,16179 0,19371005 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,16179 0,19360927 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,16179 0,19350859 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,16179 0,19340801 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,16179 0,19330754 ! glutathione metabolic process GO:0006749 29 24 0,000 0,16179 0,19320717 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,16179 0,19310691 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,16179 0,19300675 ! protein import GO:0017038 156 99 1,000 0,16384926 0,195362 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 1,000 0,16384926 0,19526077 ! regulation of translation GO:0006417 151 100 1,000 0,16643587 0,19824055 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,16643587 0,19813794 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,16643587 0,19803544 ! protein localization in organelle GO:0033365 161 100 1,000 0,16643587 0,19793304 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,16793566 0,19961345 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,16793566 0,19951034 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,16793566 0,19940734 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,16793566 0,19930445 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,16793566 0,19920166 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,16793566 0,19909898 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,16793566 0,1989964 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,16793566 0,19889393 ! peptide transport GO:0015833 43 25 0,000 0,16793566 0,19879157 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,16793566 0,19868931 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,16793566 0,19858716 ! phospholipid transport GO:0015914 35 25 0,000 0,16793566 0,19848511 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,16793566 0,19838316 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,16793566 0,19828133 ! detection of light stimulus GO:0009583 30 25 0,000 0,16793566 0,19817959 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,16793566 0,19807796 GO:0045840|positive regulation of mitosis, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,17403661 0,20516873 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,17403661 0,20506363 ! circadian rhythm GO:0007623 42 26 0,000 0,17403661 0,20495863 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,17403661 0,20485374 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,17403661 0,20474895 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,17403661 0,20464427 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,17403661 0,2045397 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,17403661 0,20443524 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,17403661 0,20433088 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,17403661 0,20422663 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,18009317 0,21122605 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,18009317 0,21111839 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,18009317 0,21101084 ! membrane docking GO:0022406 39 27 0,000 0,18009317 0,21090341 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,18009317 0,21079608 ! catechol metabolic process GO:0009712 43 27 0,000 0,18009317 0,21068885 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,18009317 0,21058174 ! acute-phase response GO:0006953 42 27 0,000 0,18009317 0,21047474 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,18009317 0,21036785 ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,18009317 0,21026106 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,18009317 0,21015438 ! natural killer cell activation GO:0030101 35 27 0,000 0,18009317 0,21004781 ! lipid oxidation GO:0034440 38 27 0,000 0,18009317 0,20994135 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,18009317 0,209835 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,18009317 0,20972875 ! gene silencing GO:0016458 41 27 0,000 0,18009317 0,20962262 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,18610566 0,21651139 ! phenol metabolic process GO:0018958 44 28 0,000 0,18610566 0,21640193 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,18610566 0,21629258 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,18610566 0,21618335 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,18610566 0,21607422 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,18610566 0,2159652 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,18610566 0,21585629 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,18610566 0,21574749 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,18610566 0,2156388 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,18610566 0,21553022 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,18610566 0,21542175 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,18610566 0,21531339 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,18610566 0,21520514 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,18610566 0,215097 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,18610566 0,21498896 ! mesoderm formation GO:0001707 46 28 0,000 0,18610566 0,21488104 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,18610566 0,21477322 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,18610566 0,21466551 ! BMP signaling pathway GO:0030509 40 28 0,000 0,18610566 0,21455791 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,18610566 0,21445041 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,18610566 0,21434303 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,18610566 0,21423575 ! regulation of innate immune response GO:0045088 38 29 0,000 0,19207441 0,22099607 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,19207441 0,22088557 ! protein targeting to membrane GO:0006612 53 29 0,000 0,19207441 0,22077518 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,19207441 0,2206649 ! mismatch repair GO:0006298 34 29 0,000 0,19207441 0,22055474 ! formation of primary germ layer GO:0001704 48 29 0,000 0,19207441 0,22044468 ! telencephalon development GO:0021537 52 29 0,000 0,19207441 0,22033473 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,19207441 0,22022489 ! eye morphogenesis GO:0048592 51 29 0,000 0,19207441 0,22011517 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,19207441 0,22000555 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,19799972 0,22667962 ! organic anion transport GO:0015711 51 30 0,000 0,19799972 0,22656684 ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,19799972 0,22645418 ! spliceosome assembly GO:0000245 49 30 0,000 0,19799972 0,22634163 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,19799972 0,22622919 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,19799972 0,22611686 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,19799972 0,22600464 ! ceramide metabolic process GO:0006672 43 30 0,000 0,19799972 0,22589254 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,19799972 0,22578054 ! adult locomotory behavior GO:0008344 47 30 0,000 0,19799972 0,22566866 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,19799972 0,22555689 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,19799972 0,22544523 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,19799972 0,22533367 ! negative regulation of secretion GO:0051048 49 31 0,000 0,20388191 0,23191316 ! glial cell differentiation GO:0010001 55 31 0,000 0,20388191 0,23179852 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,20388191 0,23168399 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,20388191 0,23156958 ! segmentation GO:0035282 41 31 0,000 0,20388191 0,23145528 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,20388191 0,2313411 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,20388191 0,23122702 ! cell fate specification GO:0001708 37 31 0,000 0,20388191 0,23111306 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,20388191 0,23099921 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,20388191 0,23088548 ! RNA modification GO:0009451 40 31 0,000 0,20388191 0,23077185 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,2097213 0,23726463 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,2097213 0,23714798 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,2097213 0,23703144 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,2097213 0,23691502 GO:0006639|acylglycerol metabolic process, ! calcium-mediated signaling GO:0019722 50 32 0,000 0,2097213 0,23679872 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,2097213 0,23668253 ! cytokine production GO:0001816 44 32 0,000 0,2097213 0,23656645 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,2097213 0,23645048 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,2097213 0,23633463 ! vesicle localization GO:0051648 47 32 0,000 0,2097213 0,2362189 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,21551819 0,24262938 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,21551819 0,24251068 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,21551819 0,24239209 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,21551819 0,24227362 ! sister chromatid segregation GO:0000819 46 33 0,000 0,21551819 0,24215526 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,21551819 0,24203702 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,21551819 0,2419189 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,21551819 0,24180089 GO:0042593|glucose homeostasis, ! lipid homeostasis GO:0055088 55 33 0,000 0,21551819 0,241683 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,21551819 0,24156522 ! regulation of proteolysis GO:0030162 50 33 0,000 0,21551819 0,24144755 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,21551819 0,24133 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,21551819 0,24121257 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,21551819 0,24109525 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,22127288 0,24741255 ! mRNA catabolic process GO:0006402 48 34 0,000 0,22127288 0,24729233 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,22127288 0,24717223 ! feeding behavior GO:0007631 45 34 0,000 0,22127288 0,24705224 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,22127288 0,24693237 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,22127288 0,24681262 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,22127288 0,24669298 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,22127288 0,24657346 ! polyol metabolic process GO:0019751 44 34 0,000 0,22127288 0,24645406 ! aerobic respiration GO:0009060 47 34 0,000 0,22127288 0,24633476 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,22127288 0,24621559 ! embryonic organ development GO:0048568 45 34 0,000 0,22127288 0,24609653 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,22127288 0,24597759 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,22698569 0,25220632 ! Notch signaling pathway GO:0007219 56 35 0,000 0,22698569 0,25208454 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,22698569 0,25196288 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,22698569 0,25184133 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,22698569 0,2517199 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,22698569 0,25159859 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,22698569 0,2514774 ! glycogen metabolic process GO:0005977 48 35 0,000 0,22698569 0,25135632 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,22698569 0,25123536 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,23265691 0,2573886 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 0,000 0,23265691 0,25726485 ! organic ether metabolic process GO:0018904 46 36 0,000 0,23265691 0,25714123 ! tissue remodeling GO:0048771 62 36 0,000 0,23265691 0,25701772 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,23265691 0,25689433 ! glucan metabolic process GO:0044042 49 36 0,000 0,23265691 0,25677106 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,23828685 0,2628584 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,23828685 0,26273239 ! learning GO:0007612 67 37 0,000 0,23828685 0,2626065 ! ion transmembrane transport GO:0034220 56 37 0,000 0,23828685 0,26248073 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,23828685 0,26235508 ! regulation of protein secretion GO:0050708 51 37 0,000 0,23828685 0,26222955 ! amino acid activation GO:0043038 52 37 0,000 0,23828685 0,26210414 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,23828685 0,26197885 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,2438758 0,26799539 ! gliogenesis GO:0042063 71 38 0,000 0,2438758 0,26786741 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,2438758 0,26773955 ! maintenance of location in cell GO:0051651 69 38 0,000 0,2438758 0,26761181 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,24942407 0,27356955 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,24942407 0,27343916 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,24942407 0,27330889 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,24942407 0,27317874 ! cell growth GO:0016049 61 39 0,000 0,24942407 0,27304872 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,25493193 0,2789455 ! regulation of tube size GO:0035150 60 40 0,000 0,25493193 0,27881286 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,25493193 0,27868034 ! peptide metabolic process GO:0006518 56 40 0,000 0,25493193 0,27854795 ! inner ear development GO:0048839 57 40 0,000 0,25493193 0,27841569 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,25493193 0,27828355 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,25493193 0,27815154 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,25493193 0,27801965 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,2603997 0,28384801 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,2603997 0,28371355 ! endosome transport GO:0016197 71 41 0,000 0,2603997 0,28357921 ! striated muscle contraction GO:0006941 62 41 0,000 0,2603997 0,28344501 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,2603997 0,28331093 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,2603997 0,28317697 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,2603997 0,28304315 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,26582764 0,2888066 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,26582764 0,28867025 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,26582764 0,28853402 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,26582764 0,28839791 ! excretion GO:0007588 63 42 0,000 0,26582764 0,28826194 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,26582764 0,2881261 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,26582764 0,28799038 ! regulation of cell shape GO:0008360 78 42 0,000 0,26582764 0,28785479 ! positive regulation of binding GO:0051099 59 43 0,000 0,27121606 0,2935515 ! leukocyte migration GO:0050900 60 43 0,000 0,27121606 0,29341343 ! neuromuscular process GO:0050905 79 43 0,000 0,27121606 0,29327548 ! tRNA processing GO:0008033 49 43 0,000 0,27121606 0,29313766 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,27121606 0,29299998 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,27656524 0,29863853 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,27656524 0,29849839 ! glycolysis GO:0006096 53 44 0,000 0,27656524 0,29835838 ! regulation of ion transport GO:0043269 57 44 0,000 0,27656524 0,2982185 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,27656524 0,29807875 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,27656524 0,29793914 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,27656524 0,29779965 ! RNA catabolic process GO:0006401 64 45 0,000 0,28187547 0,30337556 ! positive regulation of defense response GO:0031349 59 45 0,000 0,28187547 0,30323366 ! regulation of translational initiation GO:0006446 64 45 0,000 0,28187547 0,3030919 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,28187547 0,30295027 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,28187547 0,30280877 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,28714701 0,30832779 ! cell redox homeostasis GO:0045454 63 46 0,000 0,28714701 0,30818391 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,28714701 0,30804017 ! histone modification GO:0016570 68 46 0,000 0,28714701 0,30789656 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,28714701 0,30775309 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,29238016 0,31321582 ! endocrine system development GO:0035270 83 47 0,000 0,29238016 0,31307 ! covalent chromatin modification GO:0016569 75 47 0,000 0,29238016 0,31292432 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,29238016 0,31277878 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,29238016 0,31263336 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,29238016 0,31248809 ! chloride transport GO:0006821 67 48 0,000 0,29757519 0,31789268 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,29757519 0,3177451 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,29757519 0,31759765 ! gastrulation GO:0007369 73 48 0,000 0,29757519 0,31745034 ! heart morphogenesis GO:0003007 65 48 0,000 0,29757519 0,31730317 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,29757519 0,31715613 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,29757519 0,31700923 ! regulation of endocytosis GO:0030100 63 48 0,000 0,29757519 0,31686247 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,30273238 0,32220475 ! sensory perception of smell GO:0007608 61 49 0,000 0,30273238 0,32205572 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,30273238 0,32190683 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,30273238 0,32175807 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,30273238 0,32160945 ! cartilage development GO:0051216 70 49 0,000 0,30273238 0,32146097 ! maintenance of location GO:0051235 84 49 0,000 0,30273238 0,32131263 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,30785199 0,32659575 ! lipid modification GO:0030258 73 50 0,000 0,30785199 0,32644517 ! proton transport GO:0015992 75 50 0,000 0,30785199 0,32629474 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,30785199 0,32614444 ! positive regulation of secretion GO:0051047 71 51 0,000 0,31293431 0,33137611 ! hydrogen transport GO:0006818 77 51 0,000 0,31293431 0,33122361 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,31293431 0,33107125 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,31293431 0,33091904 ! adult behavior GO:0030534 80 51 0,000 0,31293431 0,33076696 ! transition metal ion transport GO:0000041 74 52 0,000 0,31797959 0,33594537 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,31797959 0,33579112 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,31797959 0,33563702 ! establishment of organelle localization GO:0051656 85 52 0,000 0,31797959 0,33548306 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,32298812 0,34061104 ! cell projection assembly GO:0030031 76 53 0,000 0,32298812 0,34045494 ! amino acid transport GO:0006865 84 54 0,000 0,32796015 0,34553749 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,32796015 0,34537928 ! regulation of mitosis GO:0007088 84 54 0,000 0,32796015 0,34522121 GO:0051783|regulation of nuclear division, ! glucose catabolic process GO:0006007 66 54 0,000 0,32796015 0,34506329 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,32796015 0,34490551 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,32796015 0,34474787 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,32796015 0,34459038 ! exocytosis GO:0006887 74 55 0,000 0,33289595 0,34961675 ! mesoderm development GO:0007498 76 55 0,000 0,33289595 0,34945718 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,33289595 0,34929776 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,33289595 0,34913848 ! chromosome segregation GO:0007059 83 57 0,000 0,3426599 0,35921503 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,3426599 0,35905137 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,3426599 0,35888787 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,34748857 0,36377956 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,34748857 0,36361406 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,34748857 0,3634487 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,35228204 0,36829486 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,35228204 0,36812753 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,35704057 0,37293066 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,35704057 0,37276138 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,35704057 0,37259225 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,35704057 0,37242327 ! regulation of heart contraction GO:0008016 91 60 0,000 0,35704057 0,37225445 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,35704057 0,37208578 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,36176441 0,37683793 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,36176441 0,37666734 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,36176441 0,3764969 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,36645382 0,38120479 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,36645382 0,38103245 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,36645382 0,38086027 ! organelle localization GO:0051640 96 62 0,000 0,36645382 0,38068825 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,37110904 0,38535024 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,37110904 0,38517635 ! regulation of lipase activity GO:0060191 109 63 0,000 0,37110904 0,38500261 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,37573032 0,38962116 ! hexose catabolic process GO:0019320 82 64 0,000 0,37573032 0,38944557 ! adaptive immune response GO:0002250 94 64 0,000 0,37573032 0,38927015 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! defense response to bacterium GO:0042742 73 65 0,000 0,3803179 0,39384564 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,3803179 0,39366839 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,3803179 0,39349131 ! activation of immune response GO:0002253 83 65 0,000 0,3803179 0,39331438 ! antigen processing and presentation GO:0019882 96 66 0,000 0,38487203 0,39784525 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,38487203 0,39766652 ! regulation of immune effector process GO:0002697 101 66 0,000 0,38487203 0,39748795 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,38939295 0,40197657 ! acute inflammatory response GO:0002526 92 68 0,000 0,39388091 0,40642714 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,39388091 0,40624488 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,39388091 0,40606279 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,39388091 0,40588086 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,39833613 0,410288 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,40275886 0,41465773 ! amine transport GO:0015837 101 70 0,000 0,40275886 0,4144722 ! regulation of catabolic process GO:0009894 106 70 0,000 0,40275886 0,41428684 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,40714933 0,41861576 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,40714933 0,41842871 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,40714933 0,41824183 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,41150777 0,4225303 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,41150777 0,42234176 ! regulation of blood pressure GO:0008217 107 73 0,000 0,41583443 0,42659196 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,41583443 0,42640177 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,42012951 0,43061403 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,42012951 0,43042222 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,42439327 0,43459685 ! amine biosynthetic process GO:0009309 97 76 0,000 0,42862591 0,43873591 ! tRNA metabolic process GO:0006399 95 76 0,000 0,42862591 0,43854075 ! response to unfolded protein GO:0006986 99 76 0,000 0,42862591 0,43834575 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,42862591 0,43815093 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,43282768 0,44224951 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,43282768 0,44205313 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,43282768 0,44185693 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,43282768 0,44166089 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,43699878 0,44571938 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,43699878 0,4455218 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,44113945 0,44954396 ! cellular respiration GO:0045333 107 79 0,000 0,44113945 0,44934487 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,44113945 0,44914596 ! regulation of lyase activity GO:0051339 133 79 0,000 0,44113945 0,44894722 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,44113945 0,44874866 ! chromatin assembly GO:0031497 102 80 0,000 0,44524989 0,45272978 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,44524989 0,45252972 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,44524989 0,45232984 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,44933035 0,45627364 ! mRNA transport GO:0051028 121 81 0,000 0,44933035 0,45607228 ! regulation of neurological system process GO:0031644 122 81 0,000 0,44933035 0,45587111 ! vitamin metabolic process GO:0006766 103 81 0,000 0,44933035 0,4556701 ! ossification GO:0001503 134 82 0,000 0,45338102 0,45957529 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,45740212 0,46344708 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,45740212 0,46324301 ! regulation of defense response GO:0031347 117 84 0,000 0,46139388 0,46708007 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,46139388 0,46687458 ! sterol metabolic process GO:0016125 120 84 0,000 0,46139388 0,46666927 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,46535649 0,4704703 ! rRNA metabolic process GO:0016072 107 85 0,000 0,46535649 0,47026359 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,46535649 0,47005706 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,46929018 0,47382239 ! nucleosome organization GO:0034728 114 87 0,000 0,47319515 0,47755544 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,47319515 0,47734598 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,47707161 0,48104546 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,47707161 0,48083466 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,47707161 0,48062405 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,48091977 0,48428873 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,48091977 0,48407679 ! hormone metabolic process GO:0042445 121 90 0,000 0,48473982 0,48770848 ! RNA localization GO:0006403 135 91 0,000 0,48853199 0,49130895 ! ATP metabolic process GO:0046034 137 91 0,000 0,48853199 0,49109422 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,49229646 0,49466223 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,49229646 0,49444622 ! positive regulation of immune response GO:0050778 121 92 0,000 0,49229646 0,4942304 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,49603344 0,49776479 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,49603344 0,49754771 ! electron transport chain GO:0022900 123 94 0,000 0,49974312 0,50105021 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,5070814 0,50818616 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,51071039 0,51160013 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,51788903 0,51856542 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,52143906 0,52189288 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,52143906 0,52166587 ! divalent metal ion transport GO:0070838 171 100 0,000 0,52143906 0,52143906