pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6262-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! negative regulation of phosphorylation GO:0042326 41 23 5,000 1,135E-08 2,611E-05 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 5,000 1,968E-08 2,264E-05 GO:0045936|negative regulation of phosphate metabolic process, ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 3,000 1,749E-06 1,341E-03 ! nuclear migration GO:0007097 10 5 2,000 3,617E-06 2,08E-03 ! cranial nerve morphogenesis GO:0021602 6 5 2,000 3,617E-06 1,664E-03 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 3,617E-06 1,387E-03 GO:0031272|regulation of pseudopodium assembly, ! regulation of intracellular protein transport GO:0033157 59 35 4,000 4,902E-06 1,611E-03 ! signal complex assembly GO:0007172 29 17 3,000 5,694E-06 1,637E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 3,000 5,694E-06 1,455E-03 ! male meiosis GO:0007140 7 6 2,000 7,197E-06 1,655E-03 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 7,197E-06 1,505E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 2,000 7,197E-06 1,379E-03 ! macrophage differentiation GO:0030225 10 6 2,000 7,197E-06 1,273E-03 ! positive regulation of intracellular transport GO:0032388 29 19 3,000 9,169E-06 1,506E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 4,000 9,654E-06 1,48E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 4,000 1,234E-05 1,774E-03 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 1,253E-05 1,695E-03 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 2,000 1,253E-05 1,601E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 1,253E-05 1,517E-03 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 4,000 1,388E-05 1,596E-03 ! gland development GO:0048732 148 77 5,000 1,941E-05 2,126E-03 ! induction of positive chemotaxis GO:0050930 14 8 2,000 1,994E-05 2,085E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,994E-05 1,994E-03 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 3,000 2,445E-05 2,343E-03 ! regulation of intracellular transport GO:0032386 78 49 4,000 2,656E-05 2,444E-03 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 2,000 2,975E-05 2,632E-03 ! nucleus localization GO:0051647 15 9 2,000 2,975E-05 2,534E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 3,235E-05 2,657E-03 ! negative regulation of protein modification process GO:0031400 50 26 3,000 3,401E-05 2,698E-03 ! anterior/posterior pattern formation GO:0009952 124 85 5,000 3,416E-05 2,619E-03 ! interphase of mitotic cell cycle GO:0051329 156 86 5,000 3,651E-05 2,708E-03 ! interphase GO:0051325 159 88 5,000 4,159E-05 2,989E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 4,228E-05 2,947E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 2,000 4,228E-05 2,86E-03 ! cranial nerve development GO:0021545 12 10 2,000 4,228E-05 2,778E-03 ! negative regulation of protein kinase activity GO:0006469 99 57 4,000 5,571E-05 3,559E-03 ! double-strand break repair via homologous recombination GO:0000724 16 11 2,000 5,783E-05 3,595E-03 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 2,000 5,783E-05 3,5E-03 ! regulation of positive chemotaxis GO:0050926 17 11 2,000 5,783E-05 3,41E-03 GO:0050927|positive regulation of positive chemotaxis, ! chondrocyte differentiation GO:0002062 17 11 2,000 5,783E-05 3,325E-03 ! negative regulation of glucose import GO:0046325 14 11 2,000 5,783E-05 3,244E-03 GO:0010829|negative regulation of glucose transport, ! negative regulation of kinase activity GO:0033673 100 58 4,000 6,061E-05 3,319E-03 ! mammary gland development GO:0030879 57 31 3,000 6,962E-05 3,724E-03 ! histone acetylation GO:0016573 23 12 2,000 7,67E-05 4,009E-03 ! peptidyl-lysine modification GO:0018205 18 12 2,000 7,67E-05 3,92E-03 ! microspike assembly GO:0030035 23 12 2,000 7,67E-05 3,835E-03 ! negative regulation of transferase activity GO:0051348 105 61 4,000 7,735E-05 3,785E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 5,000 8,062E-05 3,863E-03 ! androgen receptor signaling pathway GO:0030521 54 33 3,000 8,953E-05 4,203E-03 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 4,000 9,034E-05 4,156E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 2,000 9,918E-05 4,473E-03 ! positive regulation of protein import into nucleus GO:0042307 23 13 2,000 9,918E-05 4,387E-03 ! dorsal/ventral pattern formation GO:0009953 44 34 3,000 1,009E-04 4,379E-03 ! neural tube development GO:0021915 50 36 3,000 1,268E-04 5,399E-03 ! embryonic forelimb morphogenesis GO:0035115 17 15 2,000 1,561E-04 6,529E-03 ! regulation of the force of heart contraction GO:0002026 21 15 2,000 1,561E-04 6,412E-03 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 1,741E-04 7,023E-03 ! negative regulation of transport GO:0051051 116 73 4,000 1,823E-04 7,229E-03 ! protein amino acid acetylation GO:0006473 28 16 2,000 1,911E-04 7,452E-03 ! neutrophil chemotaxis GO:0030593 21 16 2,000 1,911E-04 7,327E-03 ! nerve development GO:0021675 18 16 2,000 1,911E-04 7,207E-03 ! positive regulation of protein transport GO:0051222 55 40 3,000 1,923E-04 7,135E-03 ! regulation of protein transport GO:0051223 114 76 4,000 2,204E-04 8,046E-03 GO:0070201|regulation of establishment of protein localization, ! forelimb morphogenesis GO:0035136 19 17 2,000 2,309E-04 8,298E-03 ! inactivation of MAPK activity GO:0000188 27 17 2,000 2,309E-04 8,17E-03 ! proximal/distal pattern formation GO:0009954 25 17 2,000 2,309E-04 8,046E-03 ! regulation of glucose import GO:0046324 21 18 2,000 2,756E-04 9,461E-03 GO:0010827|regulation of glucose transport, ! regulation of cell projection organization GO:0031344 83 44 3,000 2,794E-04 9,45E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 3,05E-04 0,01016514 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 2,000 3,256E-04 0,01069725 ! embryonic organ morphogenesis GO:0048562 23 19 2,000 3,256E-04 0,01054658 ! response to UV GO:0009411 75 46 3,000 3,321E-04 0,01061025 ! regulation of protein localization GO:0032880 132 85 4,000 3,716E-04 0,0117086 ! positive regulation of locomotion GO:0040017 35 20 2,000 3,81E-04 0,01184221 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! positive regulation of inflammatory response GO:0050729 30 20 2,000 3,81E-04 0,01168431 ! camera-type eye morphogenesis GO:0048593 34 20 2,000 3,81E-04 0,01153057 ! cell cycle arrest GO:0007050 150 86 4,000 3,923E-04 0,01171826 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 4,422E-04 0,01303859 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 4,422E-04 0,01287355 ! protein amino acid acylation GO:0043543 37 21 2,000 4,422E-04 0,01271263 ! regulation of chemotaxis GO:0050920 36 21 2,000 4,422E-04 0,01255568 ! forebrain regionalization GO:0021871 6 5 1,000 5,081E-04 0,01425162 ! embryonic camera-type eye development GO:0031076 8 5 1,000 5,081E-04 0,01407992 GO:0048596|embryonic camera-type eye morphogenesis, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 1,000 5,081E-04 0,0139123 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 5,081E-04 0,01374862 ! microvillus organization GO:0032528 7 5 1,000 5,081E-04 0,01358876 GO:0030033|microvillus assembly, ! early endosome to late endosome transport GO:0045022 11 5 1,000 5,081E-04 0,01343256 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 5,081E-04 0,01327992 ! sodium ion homeostasis GO:0055078 6 5 1,000 5,081E-04 0,01313071 ! centrosome duplication GO:0051298 5 5 1,000 5,081E-04 0,01298481 ! response to UV-C GO:0010225 6 5 1,000 5,081E-04 0,01284212 ! neural tube patterning GO:0021532 6 5 1,000 5,081E-04 0,01270253 ! muscle cell proliferation GO:0033002 8 5 1,000 5,081E-04 0,01256595 ! ectodermal gut morphogenesis GO:0048567 5 5 1,000 5,081E-04 0,01243227 GO:0007439|ectodermal gut development, ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 5,081E-04 0,0123014 GO:0022011|myelination in the peripheral nervous system, ! regulation of behavior GO:0050795 38 22 2,000 5,093E-04 0,01220219 ! cell projection assembly GO:0030031 76 53 3,000 5,733E-04 0,01359376 ! myelination GO:0042552 35 23 2,000 5,826E-04 0,01367403 ! response to light stimulus GO:0009416 153 96 4,000 6,502E-04 0,01510663 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 6,624E-04 0,01523459 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 6,624E-04 0,01508375 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 7,586E-04 0,01710464 ! prostate gland development GO:0030850 9 6 1,000 7,586E-04 0,01693858 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 7,586E-04 0,0167757 ! photoreceptor cell development GO:0042461 10 6 1,000 7,586E-04 0,01661594 GO:0046530|photoreceptor cell differentiation, ! spinal cord dorsal/ventral patterning GO:0021513 6 6 1,000 7,586E-04 0,01645918 ! ER overload response GO:0006983 7 6 1,000 7,586E-04 0,01630536 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 7,586E-04 0,01615438 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! astrocyte development GO:0014002 14 6 1,000 7,586E-04 0,01600618 ! Schwann cell development GO:0014044 14 6 1,000 7,586E-04 0,01586067 ! midbrain development GO:0030901 6 6 1,000 7,586E-04 0,01571778 ! blastocyst growth GO:0001832 15 6 1,000 7,586E-04 0,01557744 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 8,079E-04 0,01644479 ! lung development GO:0030324 94 59 3,000 8,619E-04 0,01738941 ! embryonic limb morphogenesis GO:0030326 86 60 3,000 9,184E-04 0,01836747 GO:0035113|embryonic appendage morphogenesis, ! regulation of heart contraction GO:0008016 91 60 3,000 9,184E-04 0,01820913 ! negative regulation of protein transport GO:0051224 49 27 2,000 9,423E-04 0,01852309 ! meiosis GO:0007126 96 61 3,000 9,774E-04 0,01905088 GO:0051327|M phase of meiotic cell cycle, ! respiratory tube development GO:0030323 99 62 3,000 1,039E-03 0,02008209 ! meiotic cell cycle GO:0051321 97 62 3,000 1,039E-03 0,01991474 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 1,05E-03 0,01995497 ! negative regulation of MAP kinase activity GO:0043407 54 28 2,000 1,05E-03 0,0197914 ! ensheathment of neurons GO:0007272 43 28 2,000 1,05E-03 0,0196305 GO:0008366|axon ensheathment, ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 1,057E-03 0,01960497 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,057E-03 0,01944813 ! cerebral cortex cell migration GO:0021795 11 7 1,000 1,057E-03 0,01929378 ! microtubule bundle formation GO:0001578 8 7 1,000 1,057E-03 0,01914186 ! synaptic transmission, dopaminergic GO:0001963 11 7 1,000 1,057E-03 0,01899232 ! spinal cord patterning GO:0021511 7 7 1,000 1,057E-03 0,01884509 ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 1,057E-03 0,01870013 ! cardiac muscle cell differentiation GO:0055007 12 7 1,000 1,057E-03 0,01855738 ! spinal cord motor neuron differentiation GO:0021522 9 7 1,000 1,057E-03 0,01841679 ! dopamine biosynthetic process GO:0042416 15 7 1,000 1,057E-03 0,01827832 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 3,000 1,103E-03 0,01893806 ! regulation of protein import into nucleus GO:0042306 53 29 2,000 1,165E-03 0,01984482 ! telencephalon development GO:0021537 52 29 2,000 1,165E-03 0,0196989 ! eye morphogenesis GO:0048592 51 29 2,000 1,165E-03 0,01955512 ! appendage morphogenesis GO:0035107 93 64 3,000 1,17E-03 0,01950681 GO:0035108|limb morphogenesis, ! respiratory system development GO:0060541 100 64 3,000 1,17E-03 0,01936647 ! appendage development GO:0048736 94 65 3,000 1,24E-03 0,02037593 GO:0060173|limb development, ! embryonic skeletal system morphogenesis GO:0048704 42 30 2,000 1,287E-03 0,021001 ! hindbrain development GO:0030902 45 30 2,000 1,287E-03 0,02085311 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,403E-03 0,02255992 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,403E-03 0,02240326 ! cell proliferation in forebrain GO:0021846 10 8 1,000 1,403E-03 0,02224875 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 1,403E-03 0,02209636 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,403E-03 0,02194605 ! smoothened signaling pathway GO:0007224 8 8 1,000 1,403E-03 0,02179776 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 1,403E-03 0,02165147 ! astrocyte differentiation GO:0048708 16 8 1,000 1,403E-03 0,02150713 ! embryonic eye morphogenesis GO:0048048 12 8 1,000 1,403E-03 0,0213647 ! multicellular organism growth GO:0035264 14 8 1,000 1,403E-03 0,02122414 ! Schwann cell differentiation GO:0014037 17 8 1,000 1,403E-03 0,02108542 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,403E-03 0,0209485 ! induction of an organ GO:0001759 11 8 1,000 1,403E-03 0,02081335 ! cell fate specification GO:0001708 37 31 2,000 1,418E-03 0,02090545 ! leukocyte chemotaxis GO:0030595 43 31 2,000 1,418E-03 0,0207723 GO:0060326|cell chemotaxis, ! peripheral nervous system development GO:0007422 53 32 2,000 1,556E-03 0,02265694 ! positive regulation of phosphorylation GO:0042327 102 70 3,000 1,634E-03 0,02363443 ! telencephalon cell migration GO:0022029 16 9 1,000 1,795E-03 0,02580158 ! negative regulation of striated muscle development GO:0045843 11 9 1,000 1,795E-03 0,02564132 ! ventral spinal cord development GO:0021517 11 9 1,000 1,795E-03 0,02548304 ! retinoic acid receptor signaling pathway GO:0048384 15 9 1,000 1,795E-03 0,0253267 ! receptor clustering GO:0043113 15 9 1,000 1,795E-03 0,02517227 ! motor axon guidance GO:0008045 14 9 1,000 1,795E-03 0,02501971 ! oocyte differentiation GO:0009994 12 9 1,000 1,795E-03 0,02486899 GO:0048599|oocyte development, ! localization within membrane GO:0051668 15 9 1,000 1,795E-03 0,02472007 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 3,000 1,813E-03 0,0248222 GO:0045937|positive regulation of phosphate metabolic process, ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 1,858E-03 0,02528878 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,858E-03 0,02514003 ! embryonic organ development GO:0048568 45 34 2,000 1,858E-03 0,02499301 ! regulation of action potential in neuron GO:0019228 54 35 2,000 2,022E-03 0,02703514 ! negative regulation of muscle development GO:0048635 12 10 1,000 2,233E-03 0,02968789 ! neuron fate specification GO:0048665 11 10 1,000 2,233E-03 0,02951727 ! regulation of B cell proliferation GO:0030888 15 10 1,000 2,233E-03 0,0293486 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 2,233E-03 0,02918185 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 2,233E-03 0,02901698 ! response to X-ray GO:0010165 16 10 1,000 2,233E-03 0,02885396 ! forebrain cell migration GO:0021885 17 10 1,000 2,233E-03 0,02869277 ! neurotransmitter biosynthetic process GO:0042136 14 10 1,000 2,233E-03 0,02853336 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 2,233E-03 0,02837572 ! embryonic gut development GO:0048566 11 10 1,000 2,233E-03 0,02821981 ! cardiac cell differentiation GO:0035051 16 10 1,000 2,233E-03 0,0280656 ! developmental induction GO:0031128 13 10 1,000 2,233E-03 0,02791307 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 2,233E-03 0,02776219 ! learning GO:0007612 67 37 2,000 2,375E-03 0,02937017 ! pigmentation GO:0043473 74 38 2,000 2,565E-03 0,03155149 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 2,716E-03 0,0332329 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 2,716E-03 0,03305706 ! regulation of mRNA processing GO:0050684 18 11 1,000 2,716E-03 0,03288308 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 2,716E-03 0,03271092 ! digestive tract morphogenesis GO:0048546 15 11 1,000 2,716E-03 0,03254055 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 2,716E-03 0,03237194 GO:0042130|negative regulation of T cell proliferation, ! developmental growth GO:0048589 62 39 2,000 2,765E-03 0,0327755 ! cell growth GO:0016049 61 39 2,000 2,765E-03 0,03260742 ! positive regulation of response to external stimulus GO:0032103 65 40 2,000 2,973E-03 0,03488842 ! double-strand break repair GO:0006302 67 40 2,000 2,973E-03 0,03471132 ! tyrosine metabolic process GO:0006570 14 12 1,000 3,244E-03 0,03768718 ! cell-cell junction assembly GO:0007043 18 12 1,000 3,244E-03 0,0374978 ! autonomic nervous system development GO:0048483 23 12 1,000 3,244E-03 0,03731031 ! response to gamma radiation GO:0010332 20 12 1,000 3,244E-03 0,03712469 ! regulation of DNA metabolic process GO:0051052 135 85 3,000 3,321E-03 0,03781824 ! embryonic skeletal system development GO:0048706 56 42 2,000 3,419E-03 0,03873332 ! Wnt receptor signaling pathway GO:0016055 130 87 3,000 3,611E-03 0,04071589 ! leukocyte migration GO:0050900 60 43 2,000 3,656E-03 0,04101717 ! DNA-dependent DNA replication GO:0006261 59 43 2,000 3,656E-03 0,04081806 ! response to insulin stimulus GO:0032868 63 43 2,000 3,656E-03 0,04062087 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 3,656E-03 0,04042558 ! cell differentiation in spinal cord GO:0021515 16 13 1,000 3,816E-03 0,04199677 ! bone mineralization GO:0030282 15 13 1,000 3,816E-03 0,04179679 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 3,816E-03 0,0415987 ! regulation of action potential GO:0001508 71 44 2,000 3,903E-03 0,0423432 ! induction of apoptosis by extracellular signals GO:0008624 74 44 2,000 3,903E-03 0,0421444 ! regulation of inflammatory response GO:0050727 60 44 2,000 3,903E-03 0,04194747 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 3,903E-03 0,04175236 ! positive regulation of cell cycle GO:0045787 77 45 2,000 4,16E-03 0,04429562 ! positive regulation of defense response GO:0031349 59 45 2,000 4,16E-03 0,0440915 ! histone modification GO:0016570 68 46 2,000 4,427E-03 0,0467068 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 4,431E-03 0,04653918 ! regulation of S phase GO:0033261 18 14 1,000 4,431E-03 0,04632764 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,431E-03 0,04611801 ! limbic system development GO:0021761 25 14 1,000 4,431E-03 0,04591027 ! pituitary gland development GO:0021983 23 14 1,000 4,431E-03 0,0457044 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 4,431E-03 0,04550036 GO:0031114|regulation of microtubule depolymerization, ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 4,431E-03 0,04529814 GO:0060675|ureteric bud morphogenesis, ! DNA unwinding during replication GO:0006268 21 14 1,000 4,431E-03 0,0450977 ! catecholamine biosynthetic process GO:0042423 23 14 1,000 4,431E-03 0,04489903 ! peptidyl-amino acid modification GO:0018193 147 93 3,000 4,583E-03 0,04623357 ! covalent chromatin modification GO:0016569 75 47 2,000 4,704E-03 0,04724759 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 4,704E-03 0,04704216 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of muscle contraction GO:0006937 69 48 2,000 4,992E-03 0,0497011 ! heart morphogenesis GO:0003007 65 48 2,000 4,992E-03 0,04948687 ! regulation of DNA replication GO:0006275 75 48 2,000 4,992E-03 0,04927448 ! lipid phosphorylation GO:0046834 23 15 1,000 5,089E-03 0,05002071 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 5,089E-03 0,04980786 ! centrosome cycle GO:0007098 16 15 1,000 5,089E-03 0,04959681 ! cerebral cortex development GO:0021987 29 15 1,000 5,089E-03 0,04938754 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 5,089E-03 0,04918003 ! biomineral formation GO:0031214 18 15 1,000 5,089E-03 0,04897426 ! dopamine metabolic process GO:0042417 30 15 1,000 5,089E-03 0,0487702 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 5,089E-03 0,04856783 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 5,089E-03 0,04836714 ! cartilage development GO:0051216 70 49 2,000 5,29E-03 0,05006623 ! glial cell development GO:0021782 24 16 1,000 5,789E-03 0,05456624 ! diencephalon development GO:0021536 25 16 1,000 5,789E-03 0,05434352 ! oogenesis GO:0048477 23 16 1,000 5,789E-03 0,05412261 ! G1 phase GO:0051318 27 16 1,000 5,789E-03 0,05390349 ! negative regulation of translation GO:0017148 22 16 1,000 5,789E-03 0,05368614 ! regulation of protein catabolic process GO:0042176 77 51 2,000 5,917E-03 0,05465438 ! establishment of organelle localization GO:0051656 85 52 2,000 6,247E-03 0,05746835 ! memory GO:0007613 25 17 1,000 6,53E-03 0,05983497 ! DNA duplex unwinding GO:0032508 25 17 1,000 6,53E-03 0,05959753 GO:0032392|DNA geometric change, ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 6,53E-03 0,05936197 ! neuromuscular junction development GO:0007528 23 17 1,000 6,53E-03 0,05912826 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 6,53E-03 0,05889638 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 1,000 6,53E-03 0,05866632 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 6,53E-03 0,05843805 ! peptidyl-serine modification GO:0018209 27 17 1,000 6,53E-03 0,05821154 ! cell-cell junction organization GO:0045216 25 17 1,000 6,53E-03 0,05798679 ! skeletal system morphogenesis GO:0048705 78 53 2,000 6,587E-03 0,05826922 ! regulation of protein complex assembly GO:0043254 81 54 2,000 6,938E-03 0,06114126 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 7,312E-03 0,06418573 ! response to retinoic acid GO:0032526 25 18 1,000 7,312E-03 0,06394168 ! somitogenesis GO:0001756 24 18 1,000 7,312E-03 0,06369948 ! gut development GO:0048565 26 18 1,000 7,312E-03 0,0634591 ! negative regulation of T cell activation GO:0050868 25 18 1,000 7,312E-03 0,06322054 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 7,312E-03 0,06298375 ! regulation of lipid metabolic process GO:0019216 84 56 2,000 7,674E-03 0,06585539 ! negative regulation of response to stimulus GO:0048585 80 56 2,000 7,674E-03 0,06561057 ! camera-type eye development GO:0043010 88 57 2,000 8,058E-03 0,06864113 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 8,058E-03 0,06838784 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 8,133E-03 0,06877573 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 8,133E-03 0,0685238 ! reciprocal meiotic recombination GO:0007131 31 19 1,000 8,133E-03 0,06827372 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 8,133E-03 0,06802545 ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 8,133E-03 0,06777898 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 8,133E-03 0,06753429 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 8,133E-03 0,06729136 ! response to vitamin A GO:0033189 26 19 1,000 8,133E-03 0,06705017 ! aromatic amino acid family metabolic process GO:0009072 24 19 1,000 8,133E-03 0,06681071 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 8,133E-03 0,06657295 ! protein stabilization GO:0050821 26 19 1,000 8,133E-03 0,06633687 ! myeloid cell differentiation GO:0030099 85 59 2,000 8,86E-03 0,07200711 ! response to vitamin GO:0033273 29 20 1,000 8,995E-03 0,07284572 ! hindlimb morphogenesis GO:0035137 32 20 1,000 8,995E-03 0,07259012 ! spinal cord development GO:0021510 31 20 1,000 8,995E-03 0,07233631 ! response to ethanol GO:0045471 37 20 1,000 8,995E-03 0,07208427 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 8,995E-03 0,07183397 ! neurotransmitter metabolic process GO:0042133 30 20 1,000 8,995E-03 0,07158541 ! pallium development GO:0021543 38 20 1,000 8,995E-03 0,07133857 ! positive regulation of B cell activation GO:0050871 31 20 1,000 8,995E-03 0,07109342 ! urogenital system development GO:0001655 101 61 2,000 9,707E-03 0,07646183 ! phototransduction GO:0007602 25 21 1,000 9,895E-03 0,0776752 ! dendrite development GO:0016358 35 21 1,000 9,895E-03 0,077411 ! cell aging GO:0007569 32 21 1,000 9,895E-03 0,07714859 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 9,895E-03 0,07688795 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 1,000 9,895E-03 0,07662907 GO:0060415|muscle tissue morphogenesis, ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 9,895E-03 0,07637193 ! nerve-nerve synaptic transmission GO:0007270 36 21 1,000 9,895E-03 0,0761165 ! negative regulation of cell growth GO:0030308 106 62 2,000 0,01014809 0,07780201 ! organelle localization GO:0051640 96 62 2,000 0,01014809 0,07754353 ! regulation of transcription factor activity GO:0051090 97 63 2,000 0,01060033 0,08073095 GO:0090046|regulation of transcription regulator activity, ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01083373 0,08223623 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01083373 0,08196571 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01083373 0,08169697 ! microtubule organizing center organization GO:0031023 28 22 1,000 0,01083373 0,08142999 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 0,01083373 0,08116474 ! ureteric bud development GO:0001657 32 22 1,000 0,01083373 0,08090122 ! blastocyst development GO:0001824 37 22 1,000 0,01083373 0,08063941 ! neural tube closure GO:0001843 33 22 1,000 0,01083373 0,08037928 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! negative regulation of cell size GO:0045792 108 64 2,000 0,01106409 0,08182447 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 0,01106409 0,08156221 ! reproductive structure development GO:0048608 90 65 2,000 0,01153944 0,08479459 ! neuron fate commitment GO:0048663 32 23 1,000 0,01181002 0,08650654 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01181002 0,08623192 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 0,01181002 0,08595903 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 0,01181002 0,08568787 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 0,01181002 0,08541841 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01181002 0,08515064 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01181002 0,08488455 ! negative regulation of catabolic process GO:0009895 34 23 1,000 0,01181002 0,08462011 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 1,000 0,01282345 0,09159605 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! receptor metabolic process GO:0043112 37 24 1,000 0,01282345 0,09131247 ! primary neural tube formation GO:0014020 35 24 1,000 0,01282345 0,09103064 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01282345 0,09075055 ! learning or memory GO:0007611 123 68 2,000 0,01303541 0,09196763 ! calcium-dependent cell-cell adhesion GO:0016339 30 25 1,000 0,01387342 0,09758063 ! detection of light stimulus GO:0009583 30 25 1,000 0,01387342 0,09728313 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01387342 0,09698744 ! eye development GO:0001654 111 70 2,000 0,01409141 0,09821289 ! regulation of catabolic process GO:0009894 106 70 2,000 0,01409141 0,09791617 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 0,01495937 0,10363422 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01495937 0,103323 ! response to hypoxia GO:0001666 132 72 2,000 0,0151947 0,10463414 ! tube morphogenesis GO:0035239 118 73 2,000 0,01576414 0,10823142 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 0,01576414 0,10790931 ! catechol metabolic process GO:0009712 43 27 1,000 0,01608074 0,10974988 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! response to ionizing radiation GO:0010212 47 27 1,000 0,01608074 0,10942517 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01608074 0,10910238 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,01608074 0,10878149 GO:0043433|negative regulation of transcription factor activity, ! response to oxygen levels GO:0070482 137 74 2,000 0,01634549 0,11024818 ! cellular response to hormone stimulus GO:0032870 109 74 2,000 0,01634549 0,10992582 ! negative regulation of growth GO:0045926 123 75 2,000 0,01693877 0,11358358 ! response to nutrient GO:0007584 104 75 2,000 0,01693877 0,11325339 ! phenol metabolic process GO:0018958 44 28 1,000 0,01723697 0,11491312 ! cell junction assembly GO:0034329 56 28 1,000 0,01723697 0,11458101 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,01723697 0,1142508 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01723697 0,11392249 ! neural tube formation GO:0001841 41 28 1,000 0,01723697 0,11359607 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,01723697 0,11327151 ! regulation of B cell activation GO:0050864 42 28 1,000 0,01723697 0,1129488 ! regulation of DNA binding GO:0051101 119 77 2,000 0,01816118 0,1186668 ! sex differentiation GO:0007548 105 77 2,000 0,01816118 0,11833063 ! regulation of axonogenesis GO:0050770 51 29 1,000 0,0184275 0,11972669 ! tissue homeostasis GO:0001894 42 29 1,000 0,0184275 0,11938943 GO:0048871|multicellular organismal homeostasis, ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,01879035 0,12139832 ! embryonic epithelial tube formation GO:0001838 44 30 1,000 0,01965179 0,12660816 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01965179 0,12625451 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01965179 0,12590282 ! response to heat GO:0009408 41 30 1,000 0,01965179 0,12555309 ! forebrain development GO:0030900 131 80 2,000 0,02008468 0,12796332 ! regulation of cell cycle process GO:0010564 122 81 2,000 0,02074986 0,13183611 ! glial cell differentiation GO:0010001 55 31 1,000 0,0209093 0,13248314 ! odontogenesis GO:0042476 50 31 1,000 0,0209093 0,13211918 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,0209093 0,13175721 ! segmentation GO:0035282 41 31 1,000 0,0209093 0,13139721 ! regulation of striated muscle tissue development GO:0016202 47 31 1,000 0,0209093 0,13103918 ! metanephros development GO:0001656 58 31 1,000 0,0209093 0,1306831 ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 0,0209093 0,13032894 ! ossification GO:0001503 134 82 2,000 0,02142705 0,13319521 GO:0060348|bone development, ! regulation of muscle development GO:0048634 48 32 1,000 0,02219949 0,13762485 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,02219949 0,13725489 ! meiosis I GO:0007127 52 32 1,000 0,02219949 0,13688691 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 0,02219949 0,13652091 ! regulation of protein stability GO:0031647 48 32 1,000 0,02219949 0,13615685 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,02219949 0,13579473 ! regulation of defense response GO:0031347 117 84 2,000 0,02281752 0,13920505 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 0,02281752 0,13883678 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,02352183 0,14274463 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,02352183 0,14236899 ! cell junction organization GO:0034330 63 33 1,000 0,02352183 0,14199531 ! female gonad development GO:0008585 49 33 1,000 0,02352183 0,1416236 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,02352183 0,14125382 ! cytokinesis GO:0000910 52 33 1,000 0,02352183 0,14088598 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 0,0235308 0,14057358 ! regulation of membrane potential GO:0042391 128 85 2,000 0,0235308 0,1402094 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02487581 0,14784074 ! regulation of neuron projection development GO:0010975 63 34 1,000 0,02487581 0,1474597 ! neuron migration GO:0001764 46 34 1,000 0,02487581 0,14708063 ! female gamete generation GO:0007292 43 34 1,000 0,02487581 0,1467035 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 0,02487581 0,1463283 ! skeletal muscle tissue development GO:0007519 123 87 2,000 0,0249934 0,14664497 GO:0060538|skeletal muscle organ development, ! maintenance of protein location GO:0045185 65 35 1,000 0,02626091 0,15368978 ! glycogen metabolic process GO:0005977 48 35 1,000 0,02626091 0,1532997 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 0,02626091 0,1529116 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 1,000 0,02626091 0,15252546 ! reproductive developmental process GO:0003006 127 89 2,000 0,02650406 0,15354996 ! leukocyte differentiation GO:0002521 143 90 2,000 0,02727738 0,15763311 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,0276766 0,15953932 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,0276766 0,15914047 ! negative regulation of binding GO:0051100 58 36 1,000 0,0276766 0,15874361 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,0276766 0,15834873 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,0276766 0,1579558 GO:0006073|cellular glucan metabolic process, ! cell fate commitment GO:0045165 141 92 2,000 0,02885996 0,16430176 ! DNA recombination GO:0006310 146 92 2,000 0,02885996 0,16389608 ! gliogenesis GO:0042063 71 38 1,000 0,0305978 0,17333727 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,0305978 0,17291138 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,0305978 0,17248758 ! maintenance of location in cell GO:0051651 69 38 1,000 0,0305978 0,17206585 ! regulation of binding GO:0051098 151 95 2,000 0,03132343 0,1757168 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,0321023 0,17964789 ! morphogenesis of embryonic epithelium GO:0016331 60 39 1,000 0,0321023 0,17921185 ! chromatin remodeling GO:0006338 68 39 1,000 0,0321023 0,17877792 ! synapse organization GO:0050808 55 39 1,000 0,0321023 0,17834609 ! regulation of response to external stimulus GO:0032101 139 96 2,000 0,0321684 0,17828272 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,0321684 0,17785415 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03363541 0,18551906 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,03519666 0,19366583 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,03519666 0,19320362 ! endosome transport GO:0016197 71 41 1,000 0,03519666 0,19274361 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,03519666 0,19228579 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,03519666 0,19183014 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03552534 0,19316376 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03552534 0,19270819 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03552534 0,19225475 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03552534 0,19180345 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03552534 0,19135426 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03552534 0,19090717 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03552534 0,19046217 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03552534 0,19001923 ! sleep GO:0030431 11 5 0,000 0,03552534 0,18957835 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03552534 0,18913952 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03552534 0,1887027 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03552534 0,1882679 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03552534 0,1878351 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03552534 0,18740429 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 6 5 0,000 0,03552534 0,18697545 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03552534 0,18654856 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03552534 0,18612362 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03552534 0,18570061 ! cobalt ion transport GO:0006824 9 5 0,000 0,03552534 0,18527953 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03552534 0,18486034 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03552534 0,18444305 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03552534 0,18402764 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03552534 0,18361409 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03552534 0,1832024 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03552534 0,18279255 ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03552534 0,18238453 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03552534 0,18197833 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03552534 0,18157393 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03552534 0,18117133 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,03552534 0,18077051 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,03552534 0,18037146 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03552534 0,17997416 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03552534 0,17957862 ! malate metabolic process GO:0006108 7 5 0,000 0,03552534 0,1791848 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03552534 0,17879271 ! behavioral response to pain GO:0048266 7 5 0,000 0,03552534 0,17840234 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03552534 0,17801366 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03552534 0,17762668 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03552534 0,17724137 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! mating behavior GO:0007617 6 5 0,000 0,03552534 0,17685773 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03552534 0,17647575 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03552534 0,17609541 ! rhythmic behavior GO:0007622 12 5 0,000 0,03552534 0,17571671 ! copulation GO:0007620 7 5 0,000 0,03552534 0,17533964 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03552534 0,17496418 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,03552534 0,17459032 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03552534 0,17421806 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03552534 0,17384738 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03552534 0,17347828 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03552534 0,17311074 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03552534 0,17274476 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03552534 0,17238032 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03552534 0,17201741 ! response to protozoan GO:0001562 9 5 0,000 0,03552534 0,17165603 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,03552534 0,17129616 ! lymph vessel development GO:0001945 7 5 0,000 0,03552534 0,1709378 ! endochondral ossification GO:0001958 12 5 0,000 0,03552534 0,17058094 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03552534 0,17022556 ! parathyroid gland development GO:0060017 8 5 0,000 0,03552534 0,16987166 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03552534 0,16951923 ! anagen GO:0042640 6 5 0,000 0,03552534 0,16916826 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03552534 0,16881874 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03552534 0,16847066 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03552534 0,16812401 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03552534 0,16777879 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03552534 0,16743498 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03552534 0,16709258 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03552534 0,16675157 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03552534 0,16641196 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03552534 0,16607372 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03552534 0,16573686 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,03552534 0,16540136 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03552534 0,16506721 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03552534 0,16473442 ! ovulation GO:0030728 6 5 0,000 0,03552534 0,16440296 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03552534 0,16407283 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,03552534 0,16374403 ! response to pH GO:0009268 9 5 0,000 0,03552534 0,16341654 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03552534 0,16309036 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03552534 0,16276548 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03552534 0,16244189 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03552534 0,16211958 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03552534 0,16179856 ! polyol catabolic process GO:0046174 7 5 0,000 0,03552534 0,1614788 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03552534 0,1611603 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03552534 0,16084305 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03552534 0,16052705 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03552534 0,1602123 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03552534 0,15989877 ! urea metabolic process GO:0019627 6 5 0,000 0,03552534 0,15958647 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03552534 0,15927538 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03552534 0,15896551 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,03552534 0,15865684 ! neutrophil activation GO:0042119 5 5 0,000 0,03552534 0,15834936 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03552534 0,15804308 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03552534 0,15773797 ! response to food GO:0032094 5 5 0,000 0,03552534 0,15743405 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03552534 0,15713129 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,03552534 0,15682969 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03552534 0,15652925 ! forebrain neuron development GO:0021884 7 5 0,000 0,03552534 0,15622996 ! melanosome organization GO:0032438 7 5 0,000 0,03552534 0,15593181 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03552534 0,1556348 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03552534 0,15533892 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03552534 0,15504416 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03552534 0,15475051 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03552534 0,15445798 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03552534 0,15416655 ! nucleoside transport GO:0015858 6 5 0,000 0,03552534 0,15387622 ! nucleoside salvage GO:0043174 7 5 0,000 0,03552534 0,15358697 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03552534 0,15329882 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03552534 0,15301174 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03552534 0,15272574 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03552534 0,1524408 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03552534 0,15215693 ! depyrimidination GO:0045008 8 5 0,000 0,03552534 0,15187411 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03552534 0,15159234 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03552534 0,15131161 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03552534 0,15103192 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03552534 0,15075327 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03552534 0,15047564 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03552534 0,15019903 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03552534 0,14992343 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03552534 0,14964885 ! monocyte differentiation GO:0030224 8 5 0,000 0,03552534 0,14937527 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03552534 0,14910268 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03552534 0,14883109 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03552534 0,14856049 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03552534 0,14829087 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03552534 0,14802223 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03552534 0,14775456 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03552534 0,14748785 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03552534 0,14722211 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03552534 0,14695732 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03552534 0,14669348 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03552534 0,14643059 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03552534 0,14616864 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03552534 0,14590763 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03552534 0,14564754 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03552534 0,14538838 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03552534 0,14513014 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03552534 0,14487282 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03552534 0,14461641 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03552534 0,1443609 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03552534 0,1441063 ! histone demethylation GO:0016577 9 5 0,000 0,03552534 0,14385259 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03552534 0,14359977 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03552534 0,14334784 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03552534 0,1430968 ! enteric nervous system development GO:0048484 8 5 0,000 0,03552534 0,14284663 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03552534 0,14259733 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03552534 0,1423489 ! transcription termination GO:0006353 8 5 0,000 0,03552534 0,14210134 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03552534 0,14185464 ! plasminogen activation GO:0031639 5 5 0,000 0,03552534 0,14160879 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,03552534 0,14136379 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03552534 0,14111964 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03552534 0,14087633 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03552534 0,14063386 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03552534 0,14039222 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03552534 0,14015141 ! apical protein localization GO:0045176 6 5 0,000 0,03552534 0,13991142 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03552534 0,13967226 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03552534 0,13943391 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03552534 0,13919637 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03552534 0,13895964 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03552534 0,13872372 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03552534 0,13848859 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03552534 0,13825426 ! glial cell migration GO:0008347 10 5 0,000 0,03552534 0,13802073 ! determination of adult lifespan GO:0008340 8 5 0,000 0,03552534 0,13778798 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03552534 0,13755601 ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03552534 0,13732482 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03552534 0,13709441 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03552534 0,13686477 ! neural plate development GO:0001840 6 5 0,000 0,03552534 0,1366359 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03552534 0,1364078 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03552534 0,13618045 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03552534 0,13595386 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03552534 0,13572802 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03552534 0,13550294 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03552534 0,13527859 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03552534 0,13505499 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03552534 0,13483213 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03552534 0,13461 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03552534 0,1343886 ! spindle assembly GO:0051225 5 5 0,000 0,03552534 0,13416793 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03552534 0,13394798 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03552534 0,13372876 ! organ regeneration GO:0031100 7 5 0,000 0,03552534 0,13351025 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03552534 0,13329245 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03552534 0,13307536 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03552534 0,13285898 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03552534 0,1326433 GO:0055081|anion homeostasis, ! regulation of translation GO:0006417 151 100 2,000 0,03566678 0,13295559 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,03678556 0,13690419 ! positive regulation of binding GO:0051099 59 43 1,000 0,03840164 0,14268785 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,04004444 0,14855195 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,04004444 0,14831274 ! regulation of translational initiation GO:0006446 64 45 1,000 0,04171349 0,15424601 ! cell maturation GO:0048469 60 45 1,000 0,04171349 0,15399842 ! tRNA transcription GO:0009304 11 6 0,000 0,04247869 0,1565721 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04247869 0,15632158 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04247869 0,15607187 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04247869 0,15582295 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04247869 0,15557482 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04247869 0,15532749 ! regulation of helicase activity GO:0051095 11 6 0,000 0,04247869 0,15508094 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04247869 0,15483517 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04247869 0,15459017 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04247869 0,15434596 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04247869 0,15410251 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04247869 0,15385983 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04247869 0,15361791 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04247869 0,15337675 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04247869 0,15313635 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04247869 0,1528967 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04247869 0,1526578 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04247869 0,15241964 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! neuron adhesion GO:0007158 9 6 0,000 0,04247869 0,15218223 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04247869 0,15194555 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04247869 0,15170961 ! signal peptide processing GO:0006465 8 6 0,000 0,04247869 0,1514744 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04247869 0,15123992 ! mRNA stabilization GO:0048255 15 6 0,000 0,04247869 0,15100617 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,04247869 0,15077313 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04247869 0,15054082 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04247869 0,15030922 ! opsonization GO:0008228 8 6 0,000 0,04247869 0,15007833 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04247869 0,14984814 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04247869 0,14961867 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04247869 0,14938989 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04247869 0,14916182 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04247869 0,14893444 ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04247869 0,14870775 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04247869 0,14848175 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04247869 0,14825643 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04247869 0,1480318 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04247869 0,14780785 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04247869 0,14758458 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04247869 0,14736198 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04247869 0,14714005 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04247869 0,14691878 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04247869 0,14669818 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,04247869 0,14647825 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04247869 0,14625897 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04247869 0,14604034 ! thymic T cell selection GO:0045061 12 6 0,000 0,04247869 0,14582237 ! protein lipoylation GO:0009249 10 6 0,000 0,04247869 0,14560505 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04247869 0,14538838 ! pigment granule organization GO:0048753 11 6 0,000 0,04247869 0,14517235 ! drug transport GO:0015893 6 6 0,000 0,04247869 0,14495696 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04247869 0,14474221 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04247869 0,14452809 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04247869 0,14431461 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04247869 0,14410176 ! histidine metabolic process GO:0006547 6 6 0,000 0,04247869 0,14388953 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04247869 0,14367793 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04247869 0,14346695 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04247869 0,14325658 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04247869 0,14304684 ! adenohypophysis development GO:0021984 10 6 0,000 0,04247869 0,1428377 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04247869 0,14262918 ! hyperosmotic response GO:0006972 8 6 0,000 0,04247869 0,14242127 ! microtubule nucleation GO:0007020 10 6 0,000 0,04247869 0,14221396 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04247869 0,14200725 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04247869 0,14180115 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04247869 0,14159564 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04247869 0,14139072 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,04247869 0,1411864 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04247869 0,14098267 ! response to dietary excess GO:0002021 7 6 0,000 0,04247869 0,14077952 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04247869 0,14057696 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04247869 0,14037499 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04247869 0,14017359 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04247869 0,13997277 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04247869 0,13977252 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04247869 0,13957284 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04247869 0,13937374 ! neuron apoptosis GO:0051402 8 6 0,000 0,04247869 0,1391752 ! organic alcohol transport GO:0015850 9 6 0,000 0,04247869 0,13897723 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04247869 0,13877982 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04247869 0,13858296 ! male sex determination GO:0030238 9 6 0,000 0,04247869 0,13838667 ! carnitine transport GO:0015879 8 6 0,000 0,04247869 0,13819093 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04247869 0,13799575 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04247869 0,13780111 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04247869 0,13760703 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,04247869 0,13741349 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04247869 0,13722049 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04247869 0,13702804 ! parturition GO:0007567 12 6 0,000 0,04247869 0,13683612 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04247869 0,13664474 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04247869 0,1364539 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04247869 0,13626358 ! spindle checkpoint GO:0031577 14 6 0,000 0,04247869 0,1360738 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04247869 0,13588455 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04247869 0,13569582 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04247869 0,13550761 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04247869 0,13531993 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04247869 0,13513277 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04247869 0,13494612 ! interaction with symbiont GO:0051702 8 6 0,000 0,04247869 0,13475999 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04247869 0,13457437 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04247869 0,13438926 ! eating behavior GO:0042755 6 6 0,000 0,04247869 0,13420466 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04247869 0,13402056 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04247869 0,13383697 ! response to copper ion GO:0046688 9 6 0,000 0,04247869 0,13365389 ! DNA topological change GO:0006265 8 6 0,000 0,04247869 0,1334713 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04247869 0,13328921 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04247869 0,13310762 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04247869 0,13292652 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,04247869 0,13274591 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04247869 0,13256579 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04247869 0,13238617 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04247869 0,13220702 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04247869 0,13202836 ! gas homeostasis GO:0033483 11 6 0,000 0,04247869 0,13185019 ! hair follicle maturation GO:0048820 7 6 0,000 0,04247869 0,13167249 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04247869 0,13149528 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04247869 0,13131854 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04247869 0,13114227 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04247869 0,13096647 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04247869 0,13079115 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04247869 0,1306163 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04247869 0,13044191 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04247869 0,13026799 ! histone ubiquitination GO:0016574 7 6 0,000 0,04247869 0,13009453 ! regulation of meiosis GO:0040020 10 6 0,000 0,04247869 0,12992153 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,04247869 0,12974899 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04247869 0,12957691 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04247869 0,12940528 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04247869 0,12923411 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04247869 0,1290634 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04247869 0,12889313 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04247869 0,12872331 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04247869 0,12855393 ! receptor internalization GO:0031623 9 6 0,000 0,04247869 0,12838501 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04247869 0,12821652 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04247869 0,12804848 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04247869 0,12788088 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04247869 0,12771371 ! protein deubiquitination GO:0016579 8 6 0,000 0,04247869 0,12754698 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04247869 0,12738069 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04247869 0,12721483 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04247869 0,1270494 ! axonal fasciculation GO:0007413 9 6 0,000 0,04247869 0,1268844 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04247869 0,12671983 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04247869 0,12655569 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04247869 0,12639197 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04247869 0,12622867 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04247869 0,12606579 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04247869 0,12590334 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04247869 0,1257413 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04247869 0,12557968 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04247869 0,12541847 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04247869 0,12525768 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04247869 0,1250973 ! adult feeding behavior GO:0008343 6 6 0,000 0,04247869 0,12493733 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04247869 0,12477777 ! pigment granule transport GO:0051904 12 6 0,000 0,04247869 0,12461861 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04247869 0,12445986 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04247869 0,12430151 ! catecholamine transport GO:0051937 7 6 0,000 0,04247869 0,12414357 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04247869 0,12398603 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04247869 0,12382888 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04247869 0,12367214 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04247869 0,12351579 ! protein prenylation GO:0018342 10 6 0,000 0,04247869 0,12335984 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04247869 0,12320427 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04247869 0,12304911 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04247869 0,12289433 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04247869 0,12273994 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04247869 0,12258593 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04340833 0,12511172 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,04512851 0,12990685 ! endocrine system development GO:0035270 83 47 1,000 0,04512851 0,12974446 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 1,000 0,04512851 0,12958248 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,04512851 0,12942091 ! response to temperature stimulus GO:0009266 62 48 1,000 0,04687359 0,13425809 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,04687359 0,13409111 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,04687359 0,13392453 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,04864312 0,1388079 ! RNA elongation GO:0006354 62 49 1,000 0,04864312 0,1386359 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,04864312 0,13846432 ! germ cell development GO:0007281 68 49 1,000 0,04864312 0,13829316 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,04864312 0,13812243 ! maintenance of location GO:0051235 84 49 1,000 0,04864312 0,13795212 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,04938231 0,13987601 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04938231 0,13970396 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04938231 0,13953233 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04938231 0,13936113 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04938231 0,13919034 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04938231 0,13901997 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04938231 0,13885002 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04938231 0,13868049 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04938231 0,13851136 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04938231 0,13834265 ! reproductive behavior GO:0019098 12 7 0,000 0,04938231 0,13817435 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04938231 0,13800646 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04938231 0,13783898 ! oligopeptide transport GO:0006857 11 7 0,000 0,04938231 0,1376719 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04938231 0,13750523 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04938231 0,13733896 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04938231 0,13717309 ! RNA methylation GO:0001510 11 7 0,000 0,04938231 0,13700762 ! pericardium development GO:0060039 8 7 0,000 0,04938231 0,13684255 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04938231 0,13667788 ! fibril organization GO:0043206 13 7 0,000 0,04938231 0,1365136 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,04938231 0,13634972 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04938231 0,13618623 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,04938231 0,13602314 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04938231 0,13586043 ! lipoprotein transport GO:0042953 9 7 0,000 0,04938231 0,13569811 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04938231 0,13553618 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04938231 0,13537464 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04938231 0,13521347 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04938231 0,1350527 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04938231 0,1348923 ! chemosensory behavior GO:0007635 9 7 0,000 0,04938231 0,13473229 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,04938231 0,13457265 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04938231 0,1344134 GO:0032107|regulation of response to nutrient levels, ! leukocyte degranulation GO:0043299 10 7 0,000 0,04938231 0,13425451 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04938231 0,13409601 ! reflex GO:0060004 12 7 0,000 0,04938231 0,13393788 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04938231 0,13378012 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04938231 0,13362273 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04938231 0,13346571 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04938231 0,13330906 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04938231 0,13315278 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04938231 0,13299686 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04938231 0,13284131 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04938231 0,13268612 ! adrenal gland development GO:0030325 17 7 0,000 0,04938231 0,13253129 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04938231 0,13237683 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04938231 0,13222272 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04938231 0,13206898 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04938231 0,13191559 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04938231 0,13176255 ! endosome organization GO:0007032 10 7 0,000 0,04938231 0,13160987 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04938231 0,13145755 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04938231 0,13130557 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04938231 0,13115395 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04938231 0,13100267 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04938231 0,13085175 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04938231 0,13070117 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04938231 0,13055094 ! galactose metabolic process GO:0006012 10 7 0,000 0,04938231 0,13040106 ! vesicle fusion GO:0006906 15 7 0,000 0,04938231 0,13025151 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04938231 0,13010231 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04938231 0,12995345 ! organ growth GO:0035265 11 7 0,000 0,04938231 0,12980494 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04938231 0,12965676 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04938231 0,12950892 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04938231 0,12936141 ! retinol metabolic process GO:0042572 9 7 0,000 0,04938231 0,12921424 ! behavioral fear response GO:0001662 13 7 0,000 0,04938231 0,12906741 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04938231 0,12892091 ! rRNA modification GO:0000154 12 7 0,000 0,04938231 0,12877474 ! protein heterooligomerization GO:0051291 10 7 0,000 0,04938231 0,1286289 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04938231 0,12848339 ! response to UV-B GO:0010224 11 7 0,000 0,04938231 0,12833821 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04938231 0,12819336 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04938231 0,12804884 ! intermediate filament organization GO:0045109 11 7 0,000 0,04938231 0,12790464 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04938231 0,12776076 ! fibrinolysis GO:0042730 9 7 0,000 0,04938231 0,12761721 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04938231 0,12747398 ! B cell lineage commitment GO:0002326 17 7 0,000 0,04938231 0,12733108 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04938231 0,12718849 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04938231 0,12704622 ! response to tropane GO:0014073 13 7 0,000 0,04938231 0,12690427 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04938231 0,12676263 ! melanosome localization GO:0032400 10 7 0,000 0,04938231 0,12662131 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04938231 0,12648031 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04938231 0,12633962 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04938231 0,12619924 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04938231 0,12605918 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04938231 0,12591942 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04938231 0,12577998 ! mast cell activation GO:0045576 9 7 0,000 0,04938231 0,12564084 ! multicellular organismal aging GO:0010259 11 7 0,000 0,04938231 0,12550201 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04938231 0,12536349 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04938231 0,12522527 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04938231 0,12508736 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04938231 0,12494975 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04938231 0,12481244 ! T cell lineage commitment GO:0002360 12 7 0,000 0,04938231 0,12467543 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04938231 0,12453873 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04938231 0,12440232 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04938231 0,12426621 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04938231 0,1241304 ! response to tumor cell GO:0002347 12 7 0,000 0,04938231 0,12399489 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04938231 0,12385967 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04938231 0,12372475 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04938231 0,12359012 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04938231 0,12345578 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04938231 0,12332174 ! diuresis GO:0030146 12 7 0,000 0,04938231 0,12318798 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04938231 0,12305452 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04938231 0,12292134 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04938231 0,12278845 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04938231 0,12265585 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04938231 0,12252354 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04938231 0,12239151 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04938231 0,12225976 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04938231 0,1221283 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04938231 0,12199712 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04938231 0,12186622 ! lymph node development GO:0048535 9 7 0,000 0,04938231 0,1217356 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04938231 0,12160527 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04938231 0,12147521 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04938231 0,12134543 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04938231 0,12121592 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04938231 0,12108669 ! ATP catabolic process GO:0006200 10 7 0,000 0,04938231 0,12095774 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04938231 0,12082906 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04938231 0,12070066 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04938231 0,12057253 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04938231 0,12044466 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04938231 0,12031708 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04938231 0,12018976 ! muscle adaptation GO:0043500 12 7 0,000 0,04938231 0,1200627 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04938231 0,11993592 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04938231 0,11980941 ! retina homeostasis GO:0001895 9 7 0,000 0,04938231 0,11968316 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04938231 0,11955718 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04938231 0,11943146 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04938231 0,11930601 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04938231 0,11918082 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04938231 0,11905589 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04938231 0,11893122 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04938231 0,11880682 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,05043667 0,12121665 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,05043667 0,12109011 ! lipid modification GO:0030258 73 50 1,000 0,05043667 0,12096385 ! positive regulation of growth GO:0045927 67 50 1,000 0,05043667 0,12083784 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,05043667 0,1207121 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,05043667 0,12058662 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,0522538 0,12480138 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,0522538 0,12467192 ! positive regulation of cell migration GO:0030335 92 51 1,000 0,0522538 0,12454273 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,0522538 0,1244138 ! aging GO:0007568 79 52 1,000 0,05409409 0,12866225 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,05409409 0,12852934 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,05409409 0,1283967 ! kidney development GO:0001822 90 53 1,000 0,05595711 0,13268181 ! regulation of neurotransmitter levels GO:0001505 73 53 1,000 0,05595711 0,13254517 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05623655 0,13307003 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05623655 0,13293327 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,05623655 0,13279679 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05623655 0,13266058 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05623655 0,13252466 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05623655 0,13238902 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05623655 0,13225365 ! phosphate transport GO:0006817 10 8 0,000 0,05623655 0,13211856 ! N-glycan processing GO:0006491 12 8 0,000 0,05623655 0,13198374 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05623655 0,1318492 ! UTP metabolic process GO:0046051 8 8 0,000 0,05623655 0,13171494 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05623655 0,13158094 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05623655 0,13144722 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05623655 0,13131378 ! succinate metabolic process GO:0006105 14 8 0,000 0,05623655 0,1311806 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05623655 0,13104769 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,05623655 0,13091505 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,05623655 0,13078268 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,05623655 0,13065057 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05623655 0,13051874 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05623655 0,13038717 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05623655 0,13025586 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05623655 0,13012482 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05623655 0,12999404 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05623655 0,12986352 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05623655 0,12973327 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05623655 0,12960328 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05623655 0,12947354 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05623655 0,12934407 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05623655 0,12921485 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05623655 0,1290859 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05623655 0,1289572 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05623655 0,12882875 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05623655 0,12870057 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05623655 0,12857263 ! melanin metabolic process GO:0006582 12 8 0,000 0,05623655 0,12844495 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05623655 0,12831753 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,05623655 0,12819036 ! macrophage activation GO:0042116 12 8 0,000 0,05623655 0,12806343 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05623655 0,12793676 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,05623655 0,12781034 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05623655 0,12768417 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05623655 0,12755825 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05623655 0,12743258 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05623655 0,12730715 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05623655 0,12718198 ! ruffle organization GO:0031529 11 8 0,000 0,05623655 0,12705704 ! osteoblast development GO:0002076 13 8 0,000 0,05623655 0,12693235 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05623655 0,12680791 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05623655 0,12668371 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05623655 0,12655975 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05623655 0,12643604 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05623655 0,12631257 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05623655 0,12618934 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05623655 0,12606634 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05623655 0,12594359 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,05623655 0,12582108 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,05623655 0,1256988 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05623655 0,12557677 ! segment specification GO:0007379 10 8 0,000 0,05623655 0,12545496 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05623655 0,1253334 ! cellular extravasation GO:0045123 11 8 0,000 0,05623655 0,12521207 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05623655 0,12509098 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05623655 0,12497011 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05623655 0,12484949 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05623655 0,12472909 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05623655 0,12460893 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05623655 0,124489 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05623655 0,1243693 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05623655 0,12424983 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05623655 0,12413058 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05623655 0,12401157 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05623655 0,12389279 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05623655 0,12377423 ! icosanoid secretion GO:0032309 12 8 0,000 0,05623655 0,1236559 GO:0050482|arachidonic acid secretion, ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05623655 0,12353779 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05623655 0,12341991 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05623655 0,12330226 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05623655 0,12318483 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,05623655 0,12306762 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05623655 0,12295064 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05623655 0,12283387 ! sterol catabolic process GO:0016127 9 8 0,000 0,05623655 0,12271733 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05623655 0,12260101 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05623655 0,12248491 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05623655 0,12236903 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05623655 0,12225337 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05623655 0,12213793 ! prophase GO:0051324 11 8 0,000 0,05623655 0,12202271 ! S phase GO:0051320 8 8 0,000 0,05623655 0,1219077 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05623655 0,12179291 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05623655 0,12167833 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05623655 0,12156397 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05623655 0,12144983 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05623655 0,1213359 ! hormone catabolic process GO:0042447 13 8 0,000 0,05623655 0,12122218 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05623655 0,12110868 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05623655 0,12099539 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05623655 0,12088231 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05623655 0,12076944 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05623655 0,12065678 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,05623655 0,12054433 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05623655 0,12043209 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05623655 0,12032006 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05623655 0,12020824 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05623655 0,12009663 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05623655 0,11998522 ! lamellipodium assembly GO:0030032 9 8 0,000 0,05623655 0,11987402 ! regulation of embryonic development GO:0045995 16 8 0,000 0,05623655 0,11976303 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05623655 0,11965224 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05623655 0,11954165 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05623655 0,11943127 ! regulation of mitosis GO:0007088 84 54 1,000 0,05784245 0,12272845 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,05784245 0,12261534 ! detection of external stimulus GO:0009581 66 54 1,000 0,05784245 0,12250243 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,05784245 0,12238974 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,06167845 0,13038642 ! positive regulation of cell motion GO:0051272 99 56 1,000 0,06167845 0,13026669 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,06304176 0,1330239 ! regulation of developmental growth GO:0048638 13 9 0,000 0,06304176 0,13290197 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,06304176 0,13278026 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06304176 0,13265878 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06304176 0,13253752 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06304176 0,13241648 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06304176 0,13229566 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06304176 0,13217506 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06304176 0,13205469 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06304176 0,13193453 ! GTP metabolic process GO:0046039 9 9 0,000 0,06304176 0,13181459 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06304176 0,13169486 ! social behavior GO:0035176 14 9 0,000 0,06304176 0,13157536 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06304176 0,13145607 ! artery development GO:0060840 19 9 0,000 0,06304176 0,131337 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06304176 0,13121814 ! regulation of glycolysis GO:0006110 15 9 0,000 0,06304176 0,1310995 ! response to pain GO:0048265 16 9 0,000 0,06304176 0,13098107 ! protein complex disassembly GO:0043241 17 9 0,000 0,06304176 0,13086286 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06304176 0,13074486 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06304176 0,13062707 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06304176 0,13050949 ! lung alveolus development GO:0048286 17 9 0,000 0,06304176 0,13039213 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06304176 0,13027497 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06304176 0,13015803 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06304176 0,1300413 ! protein targeting to ER GO:0045047 19 9 0,000 0,06304176 0,12992477 ! T cell selection GO:0045058 18 9 0,000 0,06304176 0,12980846 ! endoderm development GO:0007492 12 9 0,000 0,06304176 0,12969235 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06304176 0,12957645 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06304176 0,12946076 ! arginine catabolic process GO:0006527 10 9 0,000 0,06304176 0,12934527 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06304176 0,12922999 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06304176 0,12911491 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06304176 0,12900004 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,06304176 0,12888537 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,06304176 0,12877091 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06304176 0,12865665 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06304176 0,12854259 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06304176 0,12842874 ! mannose metabolic process GO:0006013 9 9 0,000 0,06304176 0,12831508 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06304176 0,12820163 ! epithelial cell development GO:0002064 10 9 0,000 0,06304176 0,12808838 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06304176 0,12797533 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06304176 0,12786247 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06304176 0,12774982 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06304176 0,12763736 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06304176 0,12752511 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06304176 0,12741305 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06304176 0,12730118 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,06304176 0,12718951 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06304176 0,12707804 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06304176 0,12696677 ! DNA ligation GO:0006266 14 9 0,000 0,06304176 0,12685568 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06304176 0,1267448 ! response to amine stimulus GO:0014075 13 9 0,000 0,06304176 0,1266341 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06304176 0,1265236 ! erythrocyte development GO:0048821 11 9 0,000 0,06304176 0,12641329 ! renal water homeostasis GO:0003091 14 9 0,000 0,06304176 0,12630318 ! postreplication repair GO:0006301 11 9 0,000 0,06304176 0,12619325 ! mRNA cleavage GO:0006379 13 9 0,000 0,06304176 0,12608352 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06304176 0,12597398 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06304176 0,12586462 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06304176 0,12575546 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06304176 0,12564649 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06304176 0,1255377 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06304176 0,12542911 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06304176 0,1253207 ! acid secretion GO:0046717 14 9 0,000 0,06304176 0,12521247 ! musculoskeletal movement GO:0050881 11 9 0,000 0,06304176 0,12510444 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06304176 0,12499659 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06304176 0,12488893 ! purine base metabolic process GO:0006144 18 9 0,000 0,06304176 0,12478145 ! thymus development GO:0048538 15 9 0,000 0,06304176 0,12467416 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06304176 0,12456705 ! spleen development GO:0048536 15 9 0,000 0,06304176 0,12446013 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,06304176 0,12435338 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06304176 0,12424683 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06304176 0,12414045 ! detection of calcium ion GO:0005513 13 9 0,000 0,06304176 0,12403426 ! blastocyst formation GO:0001825 12 9 0,000 0,06304176 0,12392824 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,06304176 0,12382241 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06304176 0,12371676 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06304176 0,12361129 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,06304176 0,123506 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06304176 0,12340089 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06304176 0,12329596 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06304176 0,1231912 ! prepulse inhibition GO:0060134 14 9 0,000 0,06304176 0,12308663 ! embryonic placenta development GO:0001892 12 9 0,000 0,06304176 0,12298223 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06304176 0,12287801 ! insulin secretion GO:0030073 17 9 0,000 0,06304176 0,12277396 ! sequestering of metal ion GO:0051238 11 9 0,000 0,06304176 0,12267009 ! response to nicotine GO:0035094 16 9 0,000 0,06304176 0,1225664 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06304176 0,12246288 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06304176 0,12235953 ! developmental maturation GO:0021700 75 57 1,000 0,06362829 0,12339381 ! gonad development GO:0008406 79 57 1,000 0,06362829 0,12328985 ! actin filament organization GO:0007015 95 59 1,000 0,06758966 0,13085539 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,0696004 0,13463493 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,0696004 0,13452179 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06979828 0,13479097 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06979828 0,13467789 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,06979828 0,134565 ! thyroid gland development GO:0030878 19 10 0,000 0,06979828 0,1344523 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06979828 0,13433979 ! synapsis GO:0007129 13 10 0,000 0,06979828 0,13422747 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06979828 0,13411533 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,06979828 0,13400338 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06979828 0,13389162 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,06979828 0,13378004 ! sulfate transport GO:0008272 12 10 0,000 0,06979828 0,13366865 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06979828 0,13355745 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,06979828 0,13344643 ! phospholipid efflux GO:0033700 16 10 0,000 0,06979828 0,13333559 ! hippocampus development GO:0021766 19 10 0,000 0,06979828 0,13322494 ! blood vessel remodeling GO:0001974 21 10 0,000 0,06979828 0,13311447 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,06979828 0,13300418 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06979828 0,13289408 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,06979828 0,13278416 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06979828 0,13267442 ! pathogenesis GO:0009405 13 10 0,000 0,06979828 0,13256486 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06979828 0,13245549 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06979828 0,13234629 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06979828 0,13223727 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,06979828 0,13212844 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06979828 0,13201978 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06979828 0,1319113 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,06979828 0,131803 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06979828 0,13169487 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06979828 0,13158693 ! B cell proliferation GO:0042100 14 10 0,000 0,06979828 0,13147916 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,06979828 0,13137156 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06979828 0,13126415 ! lipid digestion GO:0044241 15 10 0,000 0,06979828 0,1311569 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06979828 0,13104984 ! UV protection GO:0009650 14 10 0,000 0,06979828 0,13094294 ! entry into host cell GO:0030260 20 10 0,000 0,06979828 0,13083623 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,06979828 0,13072968 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06979828 0,13062331 ! negative regulation of ossification GO:0030279 19 10 0,000 0,06979828 0,13051711 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,06979828 0,13041109 ! regulation of bone resorption GO:0045124 24 10 0,000 0,06979828 0,13030524 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,06979828 0,13019955 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06979828 0,13009404 ! regulation of organ growth GO:0046620 11 10 0,000 0,06979828 0,1299887 ! response to dsRNA GO:0043331 18 10 0,000 0,06979828 0,12988354 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06979828 0,12977854 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06979828 0,12967371 ! embryonic axis specification GO:0000578 12 10 0,000 0,06979828 0,12956905 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06979828 0,12946456 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,06979828 0,12936023 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06979828 0,12925608 ! fucose catabolic process GO:0019317 16 10 0,000 0,06979828 0,12915209 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,06979828 0,12904827 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06979828 0,12894462 ! protein sumoylation GO:0016925 12 10 0,000 0,06979828 0,12884113 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06979828 0,12873781 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06979828 0,12863466 ! zymogen activation GO:0031638 14 10 0,000 0,06979828 0,12853167 ! salivary gland development GO:0007431 22 10 0,000 0,06979828 0,12842884 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06979828 0,12832618 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06979828 0,12822368 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06979828 0,12812135 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06979828 0,12801918 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,06979828 0,12791717 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,06979828 0,12781533 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06979828 0,12771364 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06979828 0,12761212 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06979828 0,12751076 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,06979828 0,12740956 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06979828 0,12730853 ! detection of bacterium GO:0016045 10 10 0,000 0,06979828 0,12720765 ! activation of innate immune response GO:0002218 10 10 0,000 0,06979828 0,12710693 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06979828 0,12700637 ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,06979828 0,12690597 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06979828 0,12680573 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06979828 0,12670564 ! cell-matrix adhesion GO:0007160 114 61 1,000 0,07163068 0,12992946 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 1,000 0,07163068 0,12982707 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 1,000 0,0736801 0,1334364 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,07574829 0,137074 ! regulation of lipase activity GO:0060191 109 63 1,000 0,07574829 0,13696624 ! rRNA transcription GO:0009303 17 11 0,000 0,07650647 0,1382285 ! respiratory burst GO:0045730 14 11 0,000 0,07650647 0,13812 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07650647 0,13801167 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07650647 0,13790351 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,07650647 0,13779552 ! virus-host interaction GO:0019048 17 11 0,000 0,07650647 0,1376877 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07650647 0,13758004 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07650647 0,13747256 ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,07650647 0,13736524 ! mating GO:0007618 14 11 0,000 0,07650647 0,13725809 ! T cell proliferation GO:0042098 20 11 0,000 0,07650647 0,13715111 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07650647 0,1370443 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,07650647 0,13693765 ! bone resorption GO:0045453 16 11 0,000 0,07650647 0,13683116 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07650647 0,13672485 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07650647 0,13661869 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07650647 0,13651271 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07650647 0,13640688 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07650647 0,13630122 ! syncytium formation GO:0006949 15 11 0,000 0,07650647 0,13619573 ! plasma membrane organization GO:0007009 18 11 0,000 0,07650647 0,13609039 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07650647 0,13598522 ! focal adhesion formation GO:0048041 24 11 0,000 0,07650647 0,13588021 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07650647 0,13577537 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07650647 0,13567068 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,07650647 0,13556616 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07650647 0,1354618 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07650647 0,1353576 ! adult heart development GO:0007512 11 11 0,000 0,07650647 0,13525356 ! temperature homeostasis GO:0001659 16 11 0,000 0,07650647 0,13514968 ! L-glutamate transport GO:0015813 16 11 0,000 0,07650647 0,13504595 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07650647 0,13494239 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07650647 0,13483899 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07650647 0,13473574 ! stem cell development GO:0048864 29 11 0,000 0,07650647 0,13463265 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07650647 0,13452972 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07650647 0,13442695 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,07650647 0,13432433 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,07650647 0,13422187 ! vasoconstriction GO:0042310 15 11 0,000 0,07650647 0,13411957 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,07650647 0,13401742 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,07650647 0,13391543 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07650647 0,13381359 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07650647 0,13371191 ! ribosome assembly GO:0042255 13 11 0,000 0,07650647 0,13361038 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07650647 0,13350901 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07650647 0,13340779 ! chromatin silencing GO:0006342 19 11 0,000 0,07650647 0,13330672 ! nucleosome positioning GO:0016584 13 11 0,000 0,07650647 0,13320581 ! T cell homeostasis GO:0043029 20 11 0,000 0,07650647 0,13310505 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07650647 0,13300444 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,07650647 0,13290399 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07650647 0,13280368 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07650647 0,13270353 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07650647 0,13260352 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07650647 0,13250367 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07650647 0,13240397 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,07650647 0,13230442 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,07650647 0,13220502 ! male genitalia development GO:0030539 13 11 0,000 0,07650647 0,13210576 ! cholesterol efflux GO:0033344 19 11 0,000 0,07650647 0,13200666 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07650647 0,1319077 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07650647 0,1318089 ! germ cell migration GO:0008354 18 11 0,000 0,07650647 0,13171024 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07650647 0,13161173 ! defense response to fungus GO:0050832 12 11 0,000 0,07650647 0,13151336 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07650647 0,13141514 ! lysogeny GO:0030069 18 11 0,000 0,07650647 0,13131707 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07650647 0,13121915 ! acrosome reaction GO:0007340 13 11 0,000 0,07650647 0,13112137 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07650647 0,13102374 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 1,000 0,07993949 0,13680121 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 1,000 0,07993949 0,1366995 ! protein oligomerization GO:0051259 100 65 1,000 0,07993949 0,13659794 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,08206177 0,14012033 ! axon guidance GO:0007411 99 66 1,000 0,08206177 0,14001638 ! lactation GO:0007595 20 12 0,000 0,08316666 0,14179638 ! reproductive cellular process GO:0048610 14 12 0,000 0,08316666 0,14169134 ! tRNA modification GO:0006400 14 12 0,000 0,08316666 0,14158647 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,08316666 0,14148174 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,08316666 0,14137717 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,08316666 0,14127276 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,08316666 0,1411685 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,08316666 0,14106439 ! non-recombinational repair GO:0000726 19 12 0,000 0,08316666 0,14096044 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,08316666 0,14085664 ! peroxisomal transport GO:0043574 21 12 0,000 0,08316666 0,14075299 ! cartilage condensation GO:0001502 18 12 0,000 0,08316666 0,1406495 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,08316666 0,14054615 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,08316666 0,14044296 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,08316666 0,14033992 ! heart looping GO:0001947 15 12 0,000 0,08316666 0,14023703 ! palate development GO:0060021 15 12 0,000 0,08316666 0,1401343 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,08316666 0,14003171 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,08316666 0,13992927 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,08316666 0,13982698 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,08316666 0,13972485 ! arginine metabolic process GO:0006525 13 12 0,000 0,08316666 0,13962286 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,08316666 0,13952102 ! methionine metabolic process GO:0006555 13 12 0,000 0,08316666 0,13941933 ! Golgi organization GO:0007030 18 12 0,000 0,08316666 0,13931778 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,08316666 0,13921639 ! monoamine transport GO:0015844 13 12 0,000 0,08316666 0,13911514 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,08316666 0,13901404 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,08316666 0,13891308 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,08316666 0,13881227 ! L-amino acid transport GO:0015807 20 12 0,000 0,08316666 0,13871161 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,08316666 0,1386111 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,08316666 0,13851073 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,08316666 0,1384105 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,08316666 0,13831042 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,08316666 0,13821049 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,08316666 0,1381107 ! cerebellum development GO:0021549 13 12 0,000 0,08316666 0,13801105 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,08316666 0,13791155 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,08316666 0,13781219 ! histone methylation GO:0016571 15 12 0,000 0,08316666 0,13771297 ! gland morphogenesis GO:0022612 23 12 0,000 0,08316666 0,1376139 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,08316666 0,13751496 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,08316666 0,13741617 ! regulation of epidermis development GO:0045682 17 12 0,000 0,08316666 0,13731753 ! intestinal absorption GO:0050892 19 12 0,000 0,08316666 0,13721902 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,08316666 0,13712066 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,08316666 0,13702243 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,08316666 0,13692435 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,08316666 0,13682641 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,08316666 0,1367286 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,08316666 0,13663094 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,08316666 0,13653342 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,08316666 0,13643603 ! response to cold GO:0009409 14 12 0,000 0,08316666 0,13633878 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,08420136 0,13793671 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,08635791 0,14136882 ! response to drug GO:0042493 108 69 1,000 0,08853105 0,1448232 ! positive regulation of ligase activity GO:0051351 99 69 1,000 0,08853105 0,14472027 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,08977919 0,14665635 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08977919 0,14655227 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08977919 0,14644833 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,08977919 0,14634454 ! water transport GO:0006833 17 13 0,000 0,08977919 0,1462409 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08977919 0,1461374 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08977919 0,14603405 ! lipid localization GO:0010876 24 13 0,000 0,08977919 0,14593085 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08977919 0,14582779 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,08977919 0,14572487 ! organelle fusion GO:0048284 28 13 0,000 0,08977919 0,14562211 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,08977919 0,14551948 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,08977919 0,14541701 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08977919 0,14531467 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08977919 0,14521248 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,08977919 0,14511043 ! glutamate metabolic process GO:0006536 18 13 0,000 0,08977919 0,14500853 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08977919 0,14490677 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,08977919 0,14480515 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,08977919 0,14470368 ! NAD metabolic process GO:0019674 21 13 0,000 0,08977919 0,14460234 ! exocrine system development GO:0035272 27 13 0,000 0,08977919 0,14450115 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,08977919 0,1444001 ! regulation of exocytosis GO:0017157 17 13 0,000 0,08977919 0,14429919 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08977919 0,14419843 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08977919 0,1440978 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08977919 0,14399731 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08977919 0,14389697 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,08977919 0,14379676 ! genitalia development GO:0048806 15 13 0,000 0,08977919 0,14369669 ! regulation of cellular pH GO:0030641 20 13 0,000 0,08977919 0,14359676 ! cellular pigmentation GO:0033059 24 13 0,000 0,08977919 0,14349698 ! tissue regeneration GO:0042246 21 13 0,000 0,08977919 0,14339732 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,08977919 0,14329781 ! cofactor transport GO:0051181 19 13 0,000 0,08977919 0,14319844 ! NADP metabolic process GO:0006739 18 13 0,000 0,08977919 0,1430992 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08977919 0,1430001 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,08977919 0,14290114 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08977919 0,14280231 ! gas transport GO:0015669 18 13 0,000 0,08977919 0,14270363 ! regulation of RNA stability GO:0043487 28 13 0,000 0,08977919 0,14260507 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08977919 0,14250666 ! regulation of axon extension GO:0030516 23 13 0,000 0,08977919 0,14240838 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,08977919 0,14231023 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,08977919 0,14221222 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08977919 0,14211435 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08977919 0,14201661 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08977919 0,141919 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08977919 0,14182153 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 1,000 0,09072046 0,14321005 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,09292577 0,14659072 ! muscle cell differentiation GO:0042692 104 71 1,000 0,09292577 0,14649025 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 1,000 0,09292577 0,14638991 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,09514666 0,14978598 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,09634441 0,15156782 ! superoxide anion generation GO:0042554 18 14 0,000 0,09634441 0,15146422 ! neuron maturation GO:0042551 21 14 0,000 0,09634441 0,15136076 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,09634441 0,15125744 ! myotube differentiation GO:0014902 21 14 0,000 0,09634441 0,15115426 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,09634441 0,15105123 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,09634441 0,15094833 ! inositol metabolic process GO:0006020 20 14 0,000 0,09634441 0,15084558 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,09634441 0,15074296 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,09634441 0,15064048 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,09634441 0,15053815 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,09634441 0,15043595 ! gene silencing by RNA GO:0031047 20 14 0,000 0,09634441 0,15033389 ! response to cAMP GO:0051591 19 14 0,000 0,09634441 0,15023197 ! startle response GO:0001964 21 14 0,000 0,09634441 0,15013018 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,09634441 0,15002854 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,09634441 0,14992703 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,09634441 0,14982566 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,09634441 0,14972443 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,09634441 0,14962333 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,09634441 0,14952237 ! glycine metabolic process GO:0006544 22 14 0,000 0,09634441 0,14942155 ! cellular response to starvation GO:0009267 21 14 0,000 0,09634441 0,14932086 ! lysosomal transport GO:0007041 20 14 0,000 0,09634441 0,1492203 ! regulation of heart rate GO:0002027 23 14 0,000 0,09634441 0,14911989 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,09634441 0,1490196 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,09634441 0,14891946 ! embryo implantation GO:0007566 27 14 0,000 0,09634441 0,14881944 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,09634441 0,14871957 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,09634441 0,14861982 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,09634441 0,14852021 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,09634441 0,14842073 ! axon cargo transport GO:0008088 27 14 0,000 0,09634441 0,14832139 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,09634441 0,14822218 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,09634441 0,1481231 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,09634441 0,14802415 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,09634441 0,14792534 ! mRNA splice site selection GO:0006376 26 14 0,000 0,09634441 0,14782665 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,09634441 0,1477281 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,09634441 0,14762968 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,09634441 0,14753139 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,09634441 0,14743324 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,09634441 0,14733521 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,09634441 0,14723731 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,09634441 0,14713954 ! muscle maintenance GO:0046716 19 14 0,000 0,09634441 0,14704191 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,09634441 0,1469444 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,09634441 0,14684702 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,09634441 0,14674977 ! cell killing GO:0001906 20 14 0,000 0,09634441 0,14665265 ! release of cytochrome c from mitochondria GO:0001836 23 14 0,000 0,09634441 0,14655566 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,09634441 0,14645879 ! cilium assembly GO:0042384 20 14 0,000 0,09634441 0,14636206 ! peptide hormone secretion GO:0030072 23 14 0,000 0,09634441 0,14626545 ! protein import into nucleus GO:0006606 118 74 1,000 0,09963382 0,15115949 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,09963382 0,15105985 ! regulation of ligase activity GO:0051340 114 75 1,000 0,10189944 0,15439309 ! nuclear import GO:0051170 121 75 1,000 0,10189944 0,15429145 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,10286265 0,15564744 ! positive regulation of cell size GO:0045793 20 15 0,000 0,10286265 0,1555451 ! metencephalon development GO:0022037 19 15 0,000 0,10286265 0,15544291 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,10286265 0,15534084 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,10286265 0,15523891 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,10286265 0,15513712 ! skin development GO:0043588 25 15 0,000 0,10286265 0,15503545 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,10286265 0,15493392 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,10286265 0,15483253 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,10286265 0,15473126 ! bile acid metabolic process GO:0008206 22 15 0,000 0,10286265 0,15463013 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,10286265 0,15452913 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,10286265 0,15442827 ! adult walking behavior GO:0007628 25 15 0,000 0,10286265 0,15432753 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,10286265 0,15422692 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,10286265 0,15412645 ! myoblast differentiation GO:0045445 27 15 0,000 0,10286265 0,15402611 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,10286265 0,1539259 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,10286265 0,15382581 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,10286265 0,15372586 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,10286265 0,15362604 ! response to osmotic stress GO:0006970 22 15 0,000 0,10286265 0,15352635 ! vesicle coating GO:0006901 25 15 0,000 0,10286265 0,15342679 ! DNA integration GO:0015074 22 15 0,000 0,10286265 0,15332735 ! peptide secretion GO:0002790 27 15 0,000 0,10286265 0,15322805 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,10286265 0,15312887 ! regulation of vasodilation GO:0042312 24 15 0,000 0,10286265 0,15302982 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,10286265 0,1529309 ! neuron recognition GO:0008038 22 15 0,000 0,10286265 0,15283211 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,10286265 0,15273344 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,10286265 0,1526349 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,10286265 0,15253649 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,10286265 0,15243821 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,10286265 0,15234005 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,10286265 0,15224202 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,10286265 0,15214412 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,10286265 0,15204634 ! organic cation transport GO:0015695 19 15 0,000 0,10286265 0,15194869 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,10286265 0,15185116 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,10286265 0,15175375 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,10286265 0,15165648 ! defense response to virus GO:0051607 27 15 0,000 0,10286265 0,15155932 ! peptide hormone processing GO:0016486 19 15 0,000 0,10286265 0,15146229 ! amine biosynthetic process GO:0009309 97 76 1,000 0,10417932 0,1533029 ! response to unfolded protein GO:0006986 99 76 1,000 0,10417932 0,15320488 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,10417932 0,15310698 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,10647313 0,15637816 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,10647313 0,15627837 ! protein ubiquitination GO:0016567 125 77 1,000 0,10647313 0,1561787 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,10878057 0,15946164 ! protein secretion GO:0009306 27 16 0,000 0,10933425 0,16017119 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,10933425 0,16006923 ! hormone secretion GO:0046879 25 16 0,000 0,10933425 0,15996741 ! bone remodeling GO:0046849 24 16 0,000 0,10933425 0,15986571 ! endothelial cell migration GO:0043542 22 16 0,000 0,10933425 0,15976415 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,10933425 0,15966271 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10933425 0,1595614 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,10933425 0,15946022 ! patterning of blood vessels GO:0001569 24 16 0,000 0,10933425 0,15935917 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,10933425 0,15925824 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,10933425 0,15915745 ! protein polyubiquitination GO:0000209 26 16 0,000 0,10933425 0,15905678 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,10933425 0,15895624 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,10933425 0,15885582 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,10933425 0,15875553 ! fructose metabolic process GO:0006000 20 16 0,000 0,10933425 0,15865537 ! regulation of protein binding GO:0043393 27 16 0,000 0,10933425 0,15855534 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,10933425 0,15845543 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,10933425 0,15835565 ! protein export from nucleus GO:0006611 24 16 0,000 0,10933425 0,15825599 ! negative regulation of immune response GO:0050777 28 16 0,000 0,10933425 0,15815646 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,10933425 0,15805705 ! DNA replication initiation GO:0006270 25 16 0,000 0,10933425 0,15795777 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,10933425 0,15785861 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,10933425 0,15775958 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,10933425 0,15766067 ! neural crest cell migration GO:0001755 24 16 0,000 0,10933425 0,15756188 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,10933425 0,15746322 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,10933425 0,15736468 ! steroid catabolic process GO:0006706 22 16 0,000 0,10933425 0,15726627 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,10933425 0,15716798 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,10933425 0,15706981 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,10933425 0,15697176 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,10933425 0,15687384 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,10933425 0,15677604 ! sperm-egg recognition GO:0035036 16 16 0,000 0,10933425 0,15667836 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,10933425 0,1565808 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,10933425 0,15648336 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,10933425 0,15638605 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,11110133 0,15881483 ! regulation of lyase activity GO:0051339 133 79 1,000 0,11110133 0,15871618 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 1,000 0,11343509 0,16194954 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 1,000 0,11343509 0,16184907 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,11575952 0,16506318 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,11575952 0,16496091 ! negative regulation of defense response GO:0031348 19 17 0,000 0,11575952 0,16485876 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,11575952 0,16475675 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,11575952 0,16465486 ! glycerol metabolic process GO:0006071 20 17 0,000 0,11575952 0,16455309 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,11575952 0,16445145 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,11575952 0,16434994 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,11575952 0,16424855 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,11575952 0,16414729 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,11575952 0,16404615 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,11575952 0,16394514 ! keratinization GO:0031424 17 17 0,000 0,11575952 0,16384425 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,11575952 0,16374348 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,11575952 0,16364284 ! retinoid metabolic process GO:0001523 22 17 0,000 0,11575952 0,16354232 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,11575952 0,16344193 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,11575952 0,16334166 ! vacuolar transport GO:0007034 24 17 0,000 0,11575952 0,16324151 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,11575952 0,16314148 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,11575952 0,16304158 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,11575952 0,1629418 ! membrane budding GO:0006900 29 17 0,000 0,11575952 0,16284214 ! heme metabolic process GO:0042168 27 17 0,000 0,11575952 0,16274261 ! actin filament bundle formation GO:0051017 26 17 0,000 0,11575952 0,16264319 ! body fluid secretion GO:0007589 27 17 0,000 0,11575952 0,1625439 ! stem cell differentiation GO:0048863 36 17 0,000 0,11575952 0,16244472 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,11575952 0,16234567 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,11575952 0,16224674 ! sensory perception of pain GO:0019233 23 17 0,000 0,11575952 0,16214793 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,11575952 0,16204924 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,11575952 0,16195067 ! synaptogenesis GO:0007416 24 17 0,000 0,11575952 0,16185222 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,11575952 0,16175389 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,11575952 0,16165568 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,11575952 0,16155759 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,11575952 0,16145961 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,11575952 0,16136176 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,11575952 0,16126402 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,11575952 0,16116641 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,11578155 0,16109956 ! response to protein stimulus GO:0051789 111 81 1,000 0,11578155 0,16100216 ! vitamin metabolic process GO:0006766 103 81 1,000 0,11578155 0,16090487 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,11578155 0,16080771 GO:0002696|positive regulation of leukocyte activation, ! detection of stimulus GO:0051606 108 82 1,000 0,11814041 0,16398488 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,12051138 0,16717501 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 1,000 0,12051138 0,16707425 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,12051138 0,1669736 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,12213881 0,16912659 ! positive regulation of translation GO:0045727 28 18 0,000 0,12213881 0,16902483 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,12213881 0,16892319 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,12213881 0,16882168 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,12213881 0,16872028 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,12213881 0,16861901 ! cAMP metabolic process GO:0046058 33 18 0,000 0,12213881 0,16851786 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,12213881 0,16841683 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,12213881 0,16831592 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,12213881 0,16821513 ! axis specification GO:0009798 26 18 0,000 0,12213881 0,16811446 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,12213881 0,16801392 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,12213881 0,16791349 ! pancreas development GO:0031016 26 18 0,000 0,12213881 0,16781318 ! apoptotic mitochondrial changes GO:0008637 29 18 0,000 0,12213881 0,167713 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,12213881 0,16761293 ! glutamine metabolic process GO:0006541 23 18 0,000 0,12213881 0,16751298 ! pigmentation during development GO:0048066 31 18 0,000 0,12213881 0,16741315 ! central nervous system neuron development GO:0021954 30 18 0,000 0,12213881 0,16731344 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,12213881 0,16721385 ! fucose metabolic process GO:0006004 26 18 0,000 0,12213881 0,16711438 ! response to fungus GO:0009620 19 18 0,000 0,12213881 0,16701502 ! peptide cross-linking GO:0018149 31 18 0,000 0,12213881 0,16691579 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,12213881 0,16681667 ! heart process GO:0003015 27 18 0,000 0,12213881 0,16671767 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,12213881 0,16661878 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,12213881 0,16652002 ! visual learning GO:0008542 35 18 0,000 0,12213881 0,16642137 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,12213881 0,16632284 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,12213881 0,16622442 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,12213881 0,16612612 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,12213881 0,16602794 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,12213881 0,16592987 ! vitamin transport GO:0051180 24 18 0,000 0,12213881 0,16583192 ! hormone transport GO:0009914 27 18 0,000 0,12213881 0,16573408 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,12213881 0,16563636 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,12213881 0,16553876 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,12213881 0,16544127 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,12213881 0,16534389 ! cell-cell recognition GO:0009988 20 18 0,000 0,12213881 0,16524663 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,12213881 0,16514948 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,12213881 0,16505245 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,12213881 0,16495553 ! sterol metabolic process GO:0016125 120 84 1,000 0,12289416 0,16587826 ! transcription initiation GO:0006352 118 85 1,000 0,12528845 0,16901082 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,12769399 0,17215485 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,12847244 0,17310288 ! positive regulation of ossification GO:0045778 30 19 0,000 0,12847244 0,17300153 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,12847244 0,1729003 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,12847244 0,17279919 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,12847244 0,1726982 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,12847244 0,17259732 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,12847244 0,17249657 ! regeneration GO:0031099 32 19 0,000 0,12847244 0,17239593 ! response to alkaloid GO:0043279 32 19 0,000 0,12847244 0,1722954 ! sensory perception of taste GO:0050909 23 19 0,000 0,12847244 0,172195 ! smooth muscle contraction GO:0006939 36 19 0,000 0,12847244 0,17209471 ! peroxisome organization GO:0007031 29 19 0,000 0,12847244 0,17199454 ! digestive system process GO:0022600 30 19 0,000 0,12847244 0,17189448 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,12847244 0,17179455 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,12847244 0,17169472 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,12847244 0,17159502 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,12847244 0,17149543 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,12847244 0,17139595 ! response to starvation GO:0042594 30 19 0,000 0,12847244 0,17129659 ! sex determination GO:0007530 29 19 0,000 0,12847244 0,17119734 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,12847244 0,17109822 ! plasma membrane fusion GO:0045026 23 19 0,000 0,12847244 0,1709992 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,12847244 0,1709003 ! cytolysis GO:0019835 20 19 0,000 0,12847244 0,17080151 ! renal system process GO:0003014 35 19 0,000 0,12847244 0,17070284 ! vasodilation GO:0042311 33 19 0,000 0,12847244 0,17060428 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,12847244 0,17050584 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,12847244 0,17040751 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,12847244 0,17030929 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,12847244 0,17021119 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,12847244 0,17011319 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,12847244 0,17001531 ! sarcomere organization GO:0045214 23 19 0,000 0,12847244 0,16991755 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,12847244 0,1698199 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,12847244 0,16972235 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,12847244 0,16962492 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,12847244 0,16952761 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,12847244 0,1694304 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,13253763 0,17469143 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,13476074 0,17751987 ! iron ion transport GO:0006826 37 20 0,000 0,13476074 0,17741826 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,13476074 0,17731676 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,13476074 0,17721538 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,13476074 0,17711411 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,13476074 0,17701296 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,13476074 0,17691193 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,13476074 0,17681101 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,13476074 0,1767102 ! chromosome condensation GO:0030261 31 20 0,000 0,13476074 0,17660951 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,13476074 0,17650894 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,13476074 0,17640848 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,13476074 0,17630813 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,13476074 0,1762079 ! DNA modification GO:0006304 28 20 0,000 0,13476074 0,17610778 ! collagen fibril organization GO:0030199 45 20 0,000 0,13476074 0,17600778 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,13476074 0,17590788 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,13476074 0,17580811 ! collagen catabolic process GO:0030574 25 20 0,000 0,13476074 0,17570844 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,13476074 0,17560889 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,13476074 0,17550945 ! alditol metabolic process GO:0019400 24 20 0,000 0,13476074 0,17541013 ! actin filament-based movement GO:0030048 34 20 0,000 0,13476074 0,17531091 ! regulation of neurogenesis GO:0050767 153 89 1,000 0,13497518 0,17549063 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,13497518 0,17539148 ! regulation of T cell activation GO:0050863 128 89 1,000 0,13497518 0,17529244 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,13742286 0,17837053 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,14100402 0,18291553 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,14100402 0,18281242 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,14100402 0,18270943 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,14100402 0,18260655 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,14100402 0,18250379 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,14100402 0,18240114 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,14100402 0,18229861 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,14100402 0,1821962 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,14100402 0,1820939 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,14100402 0,18199171 ! vesicle docking GO:0048278 27 21 0,000 0,14100402 0,18188964 ! visual behavior GO:0007632 39 21 0,000 0,14100402 0,18178769 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,14100402 0,18168585 ! ovarian follicle development GO:0001541 30 21 0,000 0,14100402 0,18158412 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,14100402 0,1814825 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,14100402 0,181381 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,14100402 0,18127962 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,14100402 0,18117834 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,14100402 0,18107718 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,14100402 0,18097614 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,14100402 0,1808752 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,14100402 0,18077438 ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,14100402 0,18067367 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,14100402 0,18057307 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,14100402 0,18047259 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,14100402 0,18037221 ! fatty acid transport GO:0015908 30 21 0,000 0,14100402 0,18027195 ! immunoglobulin production GO:0002377 33 21 0,000 0,14100402 0,1801718 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,14100402 0,18007176 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,14100402 0,17997183 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,14100402 0,17987201 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,14100402 0,1797723 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,14100402 0,17967271 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,14100402 0,17957322 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,14100402 0,17947384 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,14100402 0,17937458 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,14100402 0,17927542 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,14100402 0,17917637 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,14100402 0,17907744 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,14100402 0,17897861 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,14100402 0,17887989 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,14234751 0,18048472 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,14234751 0,18038528 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,14482396 0,18342241 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,14482396 0,18332147 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,1472026 0,18622991 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,1472026 0,18612753 ! viral genome replication GO:0019079 29 22 0,000 0,1472026 0,18602526 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,1472026 0,18592311 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,1472026 0,18582107 ! leukocyte adhesion GO:0007159 38 22 0,000 0,1472026 0,18571913 ! molting cycle process GO:0022404 40 22 0,000 0,1472026 0,18561731 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,1472026 0,18551561 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,1472026 0,18541401 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,1472026 0,18531252 ! vasculogenesis GO:0001570 33 22 0,000 0,1472026 0,18521115 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,1472026 0,18510989 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,1472026 0,18500873 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,1472026 0,18490769 ! lysosome organization GO:0007040 37 22 0,000 0,1472026 0,18480676 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,1472026 0,18470594 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,1472026 0,18460522 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,1472026 0,18450462 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,1472026 0,18440413 ! membrane depolarization GO:0051899 35 22 0,000 0,1472026 0,18430375 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,1472026 0,18420347 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,1472026 0,18410331 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,1472026 0,18400325 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,1472026 0,1839033 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,1472026 0,18380346 ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,1472026 0,18370373 ! protein tetramerization GO:0051262 39 22 0,000 0,1472026 0,18360411 ! response to oxidative stress GO:0006979 141 94 1,000 0,14730947 0,18363782 ! angiogenesis GO:0001525 149 95 1,000 0,14980379 0,18664611 ! in utero embryonic development GO:0001701 147 96 1,000 0,15230668 0,1896618 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,15230668 0,18955917 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,15335681 0,19076293 ! embryonic pattern specification GO:0009880 31 23 0,000 0,15335681 0,19065982 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,15335681 0,19055681 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,15335681 0,19045392 ! vesicle targeting GO:0006903 32 23 0,000 0,15335681 0,19035114 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,15335681 0,19024847 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,15335681 0,19014591 ! osteoblast differentiation GO:0001649 40 23 0,000 0,15335681 0,19004346 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,15335681 0,18994112 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,15335681 0,18983889 ! interaction with host GO:0051701 37 23 0,000 0,15335681 0,18973677 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,15335681 0,18963476 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,15335681 0,18953286 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,15335681 0,18943107 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,15335681 0,18932939 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,15335681 0,18922782 ! cell fate determination GO:0001709 45 23 0,000 0,15335681 0,18912636 ! pentose metabolic process GO:0019321 31 23 0,000 0,15335681 0,18902501 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,15335681 0,18892376 ! spermatid development GO:0007286 33 23 0,000 0,15335681 0,18882262 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,15335681 0,18872159 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,15335681 0,18862067 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,15335681 0,18851986 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,15335681 0,18841916 ! telomere organization GO:0032200 32 23 0,000 0,15335681 0,18831856 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,15335681 0,18821807 ! regulation of amine transport GO:0051952 38 23 0,000 0,15335681 0,18811769 ! liver development GO:0001889 40 23 0,000 0,15335681 0,18801741 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,15481786 0,18970756 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,15946695 0,19530032 ! initiation of viral infection GO:0019059 42 24 0,000 0,15946695 0,19519638 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,15946695 0,19509255 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,15946695 0,19498883 ! superoxide metabolic process GO:0006801 32 24 0,000 0,15946695 0,19488523 ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,15946695 0,19478173 ! fat cell differentiation GO:0045444 37 24 0,000 0,15946695 0,19467834 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,15946695 0,19457506 ! sperm motility GO:0030317 27 24 0,000 0,15946695 0,1944719 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,15946695 0,19436884 ! vacuole organization GO:0007033 39 24 0,000 0,15946695 0,19426589 ! neural crest cell development GO:0014032 39 24 0,000 0,15946695 0,19416305 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,15946695 0,19406032 ! negative regulation of cell development GO:0010721 56 24 0,000 0,15946695 0,19395769 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,15946695 0,19385518 ! base-excision repair GO:0006284 31 24 0,000 0,15946695 0,19375277 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,15946695 0,19365047 GO:0002708|positive regulation of lymphocyte mediated immunity, ! glutathione metabolic process GO:0006749 29 24 0,000 0,15946695 0,19354828 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,15946695 0,1934462 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,15946695 0,19334423 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,15946695 0,19324236 ! extracellular structure organization GO:0043062 156 99 1,000 0,15986418 0,1936217 ! protein import GO:0017038 156 99 1,000 0,15986418 0,19351979 ! homophilic cell adhesion GO:0007156 149 100 1,000 0,16239882 0,19648463 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,16239882 0,19638132 ! protein localization in organelle GO:0033365 161 100 1,000 0,16239882 0,19627813 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,16553335 0,19996151 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,16553335 0,19985654 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,16553335 0,19975168 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,16553335 0,19964694 GO:0006479|protein amino acid methylation, ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,16553335 0,1995423 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,16553335 0,19943777 ! peptide transport GO:0015833 43 25 0,000 0,16553335 0,19933336 ! male gonad development GO:0008584 33 25 0,000 0,16553335 0,19922905 ! iron ion homeostasis GO:0055072 39 25 0,000 0,16553335 0,19912485 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,16553335 0,19902076 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,16553335 0,19891678 ! regulation of chromosome organization GO:0033044 35 25 0,000 0,16553335 0,1988129 ! phospholipid transport GO:0015914 35 25 0,000 0,16553335 0,19870914 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,16553335 0,19860548 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,16553335 0,19850193 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,16553335 0,19839849 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,16553335 0,19829516 ! leukocyte proliferation GO:0070661 39 25 0,000 0,16553335 0,19819194 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,17155631 0,20529631 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,17155631 0,20518956 ! translational initiation GO:0006413 43 26 0,000 0,17155631 0,20508291 ! regulation of pH GO:0006885 36 26 0,000 0,17155631 0,20497637 ! circadian rhythm GO:0007623 42 26 0,000 0,17155631 0,20486995 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,17155631 0,20476363 ! post-embryonic development GO:0009791 42 26 0,000 0,17155631 0,20465743 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,17155631 0,20455133 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,17155631 0,20444535 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,17155631 0,20433947 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,17155631 0,2042337 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,17155631 0,20412805 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,17155631 0,2040225 ! regulation of coagulation GO:0050818 39 26 0,000 0,17155631 0,20391706 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,17753614 0,21091587 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,17753614 0,21080698 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,17753614 0,21069821 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,17753614 0,21058954 ! membrane docking GO:0022406 39 27 0,000 0,17753614 0,21048099 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,17753614 0,21037255 ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,17753614 0,21026422 ! acute-phase response GO:0006953 42 27 0,000 0,17753614 0,21015601 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,17753614 0,2100479 ! myofibril assembly GO:0030239 36 27 0,000 0,17753614 0,20993991 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,17753614 0,20983203 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,17753614 0,20972425 ! natural killer cell activation GO:0030101 35 27 0,000 0,17753614 0,20961659 ! lipid oxidation GO:0034440 38 27 0,000 0,17753614 0,20950904 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,17753614 0,2094016 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,17753614 0,20929427 ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,17753614 0,20918705 ! gene silencing GO:0016458 41 27 0,000 0,17753614 0,20907994 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,18347315 0,21596123 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,18347315 0,21585076 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,18347315 0,21574041 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,18347315 0,21563017 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,18347315 0,21552004 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,18347315 0,21541002 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,18347315 0,21530012 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,18347315 0,21519033 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,18347315 0,21508065 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,18347315 0,21497108 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,18347315 0,21486163 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,18347315 0,21475228 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,18347315 0,21464305 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,18347315 0,21453393 ! mesoderm formation GO:0001707 46 28 0,000 0,18347315 0,21442492 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,18347315 0,21431602 ! BMP signaling pathway GO:0030509 40 28 0,000 0,18347315 0,21420723 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,18347315 0,21409855 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,18347315 0,21398998 ! placenta development GO:0001890 37 28 0,000 0,18347315 0,21388152 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,18936763 0,22064111 ! regulation of innate immune response GO:0045088 38 29 0,000 0,18936763 0,2205294 ! ovulation cycle process GO:0022602 41 29 0,000 0,18936763 0,22041779 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,18936763 0,2203063 ! protein targeting to membrane GO:0006612 53 29 0,000 0,18936763 0,22019492 ! mismatch repair GO:0006298 34 29 0,000 0,18936763 0,22008366 ! muscle cell development GO:0055001 38 29 0,000 0,18936763 0,2199725 ! formation of primary germ layer GO:0001704 48 29 0,000 0,18936763 0,21986146 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,18936763 0,21975053 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,18936763 0,21963972 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,19521991 0,2263134 ! collagen metabolic process GO:0032963 40 30 0,000 0,19521991 0,22619939 ! organic anion transport GO:0015711 51 30 0,000 0,19521991 0,22608549 ! cholesterol transport GO:0030301 46 30 0,000 0,19521991 0,22597171 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,19521991 0,22585804 ! spindle organization GO:0007051 37 30 0,000 0,19521991 0,22574449 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,19521991 0,22563105 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,19521991 0,22551772 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,19521991 0,22540451 ! ceramide metabolic process GO:0006672 43 30 0,000 0,19521991 0,22529141 ! ovulation cycle GO:0042698 43 30 0,000 0,19521991 0,22517843 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,19521991 0,22506555 ! adult locomotory behavior GO:0008344 47 30 0,000 0,19521991 0,2249528 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,19521991 0,22484015 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,19521991 0,22472762 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,20103026 0,23130045 ! negative regulation of secretion GO:0051048 49 31 0,000 0,20103026 0,2311848 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,20103026 0,23106926 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,20103026 0,23095384 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,20103026 0,23083854 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,20103026 0,23072335 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,20103026 0,23060828 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,20103026 0,23049332 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,20103026 0,23037847 ! RNA modification GO:0009451 40 31 0,000 0,20103026 0,23026374 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,20679899 0,23675345 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,20679899 0,23663566 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,20679899 0,23651799 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,20679899 0,23640044 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,20679899 0,236283 GO:0006639|acylglycerol metabolic process, ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,20679899 0,23616568 ! cytokine production GO:0001816 44 32 0,000 0,20679899 0,23604848 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,20679899 0,23593139 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,20679899 0,23581442 ! vesicle localization GO:0051648 47 32 0,000 0,20679899 0,23569756 ! RNA export from nucleus GO:0006405 44 33 0,000 0,2125264 0,24210536 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,2125264 0,24198551 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,2125264 0,24186577 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,2125264 0,24174616 ! sister chromatid segregation GO:0000819 46 33 0,000 0,2125264 0,24162666 ! ear morphogenesis GO:0042471 42 33 0,000 0,2125264 0,24150728 ! actomyosin structure organization GO:0031032 43 33 0,000 0,2125264 0,24138802 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,2125264 0,24126887 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,2125264 0,24114984 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,2125264 0,24103093 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 0,000 0,2125264 0,24091214 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,2125264 0,24079346 ! positive regulation of cell development GO:0010720 54 33 0,000 0,2125264 0,2406749 ! lipid homeostasis GO:0055088 55 33 0,000 0,2125264 0,24055646 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,2125264 0,24043814 ! regulation of proteolysis GO:0030162 50 33 0,000 0,2125264 0,24031993 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,2125264 0,24020183 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,2125264 0,24008386 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,2125264 0,23996599 ! mRNA catabolic process GO:0006402 48 34 0,000 0,21821279 0,24626566 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,21821279 0,24614488 ! feeding behavior GO:0007631 45 34 0,000 0,21821279 0,24602422 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,21821279 0,24590368 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,21821279 0,24578326 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,21821279 0,24566295 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,21821279 0,24554276 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,21821279 0,24542269 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,21821279 0,24530274 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,21821279 0,24518291 ! polyol metabolic process GO:0019751 44 34 0,000 0,21821279 0,24506319 ! aerobic respiration GO:0009060 47 34 0,000 0,21821279 0,24494359 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,22385843 0,25115824 ! Notch signaling pathway GO:0007219 56 35 0,000 0,22385843 0,25103578 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,22385843 0,25091344 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,22385843 0,25079123 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,22385843 0,25066913 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,22385843 0,25054715 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,22385843 0,25042529 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,22385843 0,25030354 ! pigment metabolic process GO:0042440 61 35 0,000 0,22385843 0,25018192 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,22946362 0,25632168 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,22946362 0,25619725 ! organic ether metabolic process GO:0018904 46 36 0,000 0,22946362 0,25607294 ! tissue remodeling GO:0048771 62 36 0,000 0,22946362 0,25594876 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,22946362 0,25582469 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,22946362 0,25570074 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,22946362 0,25557692 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,23502866 0,26164856 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,23502866 0,26152197 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,23502866 0,26139551 ! ion transmembrane transport GO:0034220 56 37 0,000 0,23502866 0,26126917 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,23502866 0,26114295 ! regulation of protein secretion GO:0050708 51 37 0,000 0,23502866 0,26101686 ! amino acid activation GO:0043038 52 37 0,000 0,23502866 0,26089089 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,23502866 0,26076503 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,24055382 0,26676653 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,24055382 0,26663797 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,24055382 0,26650953 ! phagocytosis GO:0006909 60 38 0,000 0,24055382 0,26638121 ! mesenchymal cell development GO:0014031 64 38 0,000 0,24055382 0,26625302 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,24603938 0,27219364 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,24603938 0,27206278 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,24603938 0,27193204 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,24603938 0,27180143 ! male sex differentiation GO:0046661 53 39 0,000 0,24603938 0,27167095 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,24603938 0,27154059 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,24603938 0,27141035 ! JNK cascade GO:0007254 54 39 0,000 0,24603938 0,27128024 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,25148564 0,27715236 ! response to calcium ion GO:0051592 58 40 0,000 0,25148564 0,27701962 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,25148564 0,27688701 ! regulation of tube size GO:0035150 60 40 0,000 0,25148564 0,27675453 GO:0050880|regulation of blood vessel size, ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,25148564 0,27662218 ! peptide metabolic process GO:0006518 56 40 0,000 0,25148564 0,27648995 ! inner ear development GO:0048839 57 40 0,000 0,25148564 0,27635785 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,25148564 0,27622587 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,25148564 0,27609402 ! B cell differentiation GO:0030183 62 40 0,000 0,25148564 0,2759623 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,25148564 0,2758307 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,25148564 0,27569922 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,25148564 0,27556788 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,25689286 0,28135885 ! glucose transport GO:0015758 52 41 0,000 0,25689286 0,28122493 ! striated muscle contraction GO:0006941 62 41 0,000 0,25689286 0,28109115 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,25689286 0,28095748 ! biopolymer methylation GO:0043414 62 41 0,000 0,25689286 0,28082395 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,25689286 0,28069054 ! mitochondrial transport GO:0006839 60 42 0,000 0,26226133 0,28642026 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,26226133 0,28628432 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,26226133 0,28614852 ! cellular component disassembly GO:0022411 64 42 0,000 0,26226133 0,28601284 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,26226133 0,28587728 ! hexose transport GO:0008645 54 42 0,000 0,26226133 0,28574186 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,26226133 0,28560657 ! excretion GO:0007588 63 42 0,000 0,26226133 0,2854714 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,26226133 0,28533636 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,26226133 0,28520145 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,26226133 0,28506667 ! regulation of cell shape GO:0008360 78 42 0,000 0,26226133 0,28493201 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,26759133 0,29058548 ! neuromuscular process GO:0050905 79 43 0,000 0,26759133 0,29044835 ! activation of caspase activity GO:0006919 65 43 0,000 0,26759133 0,29031135 ! tRNA processing GO:0008033 49 43 0,000 0,26759133 0,29017447 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,26759133 0,29003773 ! vesicle organization GO:0016050 79 43 0,000 0,26759133 0,28990111 ! methylation GO:0032259 64 43 0,000 0,26759133 0,28976462 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,27288312 0,29535584 ! glycolysis GO:0006096 53 44 0,000 0,27288312 0,29521692 ! regulation of ion transport GO:0043269 57 44 0,000 0,27288312 0,29507812 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,27288312 0,29493946 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,27288312 0,29480092 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,27288312 0,29466252 ! RNA catabolic process GO:0006401 64 45 0,000 0,27813697 0,30019476 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,27813697 0,30005396 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,27813697 0,29991328 ! cell recognition GO:0008037 58 45 0,000 0,27813697 0,29977274 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,28335316 0,30525165 ! cell redox homeostasis GO:0045454 63 46 0,000 0,28335316 0,30510874 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,28335316 0,30496597 ! regulation of ossification GO:0030278 71 46 0,000 0,28335316 0,30482333 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,28335316 0,30468082 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,28853196 0,31010444 ! viral infectious cycle GO:0019058 71 47 0,000 0,28853196 0,3099596 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,28853196 0,3098149 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,28853196 0,30967033 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,28853196 0,30952589 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,28853196 0,30938159 ! chloride transport GO:0006821 67 48 0,000 0,29367363 0,31474806 ! positive regulation of caspase activity GO:0043280 72 48 0,000 0,29367363 0,31460146 GO:0010952|positive regulation of peptidase activity, ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,29367363 0,314455 ! gastrulation GO:0007369 73 48 0,000 0,29367363 0,31430867 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,29367363 0,31416248 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,29367363 0,31401643 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,29367363 0,31387051 ! regulation of endocytosis GO:0030100 63 48 0,000 0,29367363 0,31372473 ! nuclear export GO:0051168 69 48 0,000 0,29367363 0,31357908 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,29367363 0,31343357 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,29877843 0,31873395 ! sensory perception of smell GO:0007608 61 49 0,000 0,29877843 0,31858618 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,29877843 0,31843855 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,29877843 0,31829105 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,29877843 0,3181437 ! regulation of actin filament length GO:0030832 72 50 0,000 0,30384663 0,32339067 ! ear development GO:0043583 72 50 0,000 0,30384663 0,32324109 ! membrane fusion GO:0006944 80 50 0,000 0,30384663 0,32309165 ! proton transport GO:0015992 75 50 0,000 0,30384663 0,32294235 ! positive regulation of secretion GO:0051047 71 51 0,000 0,30887849 0,32813881 ! hydrogen transport GO:0006818 77 51 0,000 0,30887849 0,32798731 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,30887849 0,32783596 ! adult behavior GO:0030534 80 51 0,000 0,30887849 0,32768474 ! transition metal ion transport GO:0000041 74 52 0,000 0,31387426 0,33283116 ! regulation of cellular component size GO:0032535 74 52 0,000 0,31387426 0,33267778 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,31387426 0,33252455 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,3188342 0,3376237 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,3188342 0,33746832 ! single fertilization GO:0007338 59 53 0,000 0,3188342 0,33731309 ! amino acid transport GO:0006865 84 54 0,000 0,32375858 0,34236539 ! glucose catabolic process GO:0006007 66 54 0,000 0,32375858 0,34220805 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,32375858 0,34205086 ! DNA catabolic process GO:0006308 67 54 0,000 0,32375858 0,34189381 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,32375858 0,34173691 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,32375858 0,34158015 ! exocytosis GO:0006887 74 55 0,000 0,32864763 0,34657934 ! mesoderm development GO:0007498 76 55 0,000 0,32864763 0,34642051 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,32864763 0,34626182 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,32864763 0,34610327 ! carbohydrate transport GO:0008643 74 57 0,000 0,33832078 0,35612714 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,33832078 0,35596422 GO:0048609|reproductive process in a multicellular organism, ! chromosome segregation GO:0007059 83 57 0,000 0,33832078 0,35580146 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,33832078 0,35563885 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,33832078 0,35547638 ! secondary metabolic process GO:0019748 84 57 0,000 0,33832078 0,35531406 ! viral reproductive process GO:0022415 87 58 0,000 0,34310538 0,36017452 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,34310538 0,3600102 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,34310538 0,35984604 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,34785565 0,3646618 ! activation of MAPK activity GO:0000187 84 59 0,000 0,34785565 0,36449567 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,34785565 0,36432969 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,35257184 0,36910115 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,35257184 0,36893322 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,35257184 0,36876545 ! fertilization GO:0009566 68 60 0,000 0,35257184 0,36859783 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,35257184 0,36843036 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,35725419 0,37315379 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,35725419 0,3729844 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,35725419 0,37281517 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,35725419 0,37264609 ! extracellular matrix organization GO:0030198 103 61 0,000 0,35725419 0,37247717 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,35725419 0,3723084 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! amine catabolic process GO:0009310 90 62 0,000 0,36190295 0,37698224 ! neurotransmitter transport GO:0006836 81 62 0,000 0,36190295 0,37681158 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,36190295 0,37664108 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,36190295 0,37647073 ! viral reproduction GO:0016032 92 63 0,000 0,36651834 0,38109954 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,37110062 0,38568976 ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,37110062 0,38551555 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,37110062 0,3853415 ! hexose catabolic process GO:0019320 82 64 0,000 0,37110062 0,38516761 ! adaptive immune response GO:0002250 94 64 0,000 0,37110062 0,38499388 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! regulation of caspase activity GO:0043281 97 65 0,000 0,37565001 0,38953789 ! B cell activation GO:0042113 104 65 0,000 0,37565001 0,38936234 ! defense response to bacterium GO:0042742 73 65 0,000 0,37565001 0,38918695 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,37565001 0,38901172 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,37565001 0,38883665 ! activation of immune response GO:0002253 83 65 0,000 0,37565001 0,38866173 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,38016676 0,39315807 ! antigen processing and presentation GO:0019882 96 66 0,000 0,38016676 0,39298137 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,38016676 0,39280482 ! regulation of immune effector process GO:0002697 101 66 0,000 0,38016676 0,39262844 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,38465108 0,39708146 ! regulation of endopeptidase activity GO:0052548 99 67 0,000 0,38465108 0,39690331 ! acute inflammatory response GO:0002526 92 68 0,000 0,38910322 0,40131722 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,38910322 0,40113734 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,38910322 0,40095762 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,38910322 0,40077806 ! rhythmic process GO:0048511 105 68 0,000 0,38910322 0,40059866 ! inorganic anion transport GO:0015698 93 68 0,000 0,38910322 0,40041942 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,3935234 0,40478704 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,3935234 0,40460608 ! response to metal ion GO:0010038 103 70 0,000 0,39791184 0,40893532 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,39791184 0,40875268 ! humoral immune response GO:0006959 86 70 0,000 0,39791184 0,4085702 ! amine transport GO:0015837 101 70 0,000 0,39791184 0,40838788 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,40226879 0,41267538 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,40226879 0,4124914 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,40226879 0,41230758 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,40226879 0,41212393 ! regulation of peptidase activity GO:0052547 106 72 0,000 0,40659445 0,4163701 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,40659445 0,4161848 ! regulation of blood pressure GO:0008217 107 73 0,000 0,41088906 0,42039361 ! mitochondrion organization GO:0007005 104 73 0,000 0,41088906 0,42020669 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,41088906 0,42001993 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,41515283 0,42418992 ! digestion GO:0007586 97 74 0,000 0,41515283 0,42400156 ! blood coagulation GO:0007596 116 75 0,000 0,41938598 0,42813482 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,41938598 0,42794488 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,41938598 0,4277551 ! tRNA metabolic process GO:0006399 95 76 0,000 0,42358874 0,43185022 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,42776131 0,43591095 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,42776131 0,4357179 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,42776131 0,43552502 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,43190392 0,43954824 ! cellular respiration GO:0045333 107 79 0,000 0,43601677 0,44353763 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,43601677 0,44334155 ! T cell activation GO:0042110 134 79 0,000 0,43601677 0,44314564 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,43601677 0,4429499 ! chromatin assembly GO:0031497 102 80 0,000 0,44010009 0,44690075 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,44010009 0,44670353 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,44010009 0,44650648 ! hemostasis GO:0007599 125 81 0,000 0,44415407 0,45042079 ! mRNA transport GO:0051028 121 81 0,000 0,44415407 0,45022228 ! regulation of neurological system process GO:0031644 122 81 0,000 0,44415407 0,45002394 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,45614211 0,46196691 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,46008084 0,46575085 ! rRNA metabolic process GO:0016072 107 85 0,000 0,46008084 0,46554595 GO:0006364|rRNA processing, ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,46008084 0,46534122 ! nucleosome organization GO:0034728 114 87 0,000 0,46787361 0,47301508 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,46787361 0,47280725 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,46787361 0,47259961 ! female pregnancy GO:0007565 130 87 0,000 0,46787361 0,47239215 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,47172805 0,47607482 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,47172805 0,47586601 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,47172805 0,47565739 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,47172805 0,47544895 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,47555479 0,47909593 ! hormone metabolic process GO:0042445 121 90 0,000 0,47935402 0,48271202 ! RNA localization GO:0006403 135 91 0,000 0,48312595 0,48629746 ! ATP metabolic process GO:0046034 137 91 0,000 0,48312595 0,48608473 ! response to virus GO:0009615 122 91 0,000 0,48312595 0,48587219 ! positive regulation of immune response GO:0050778 121 92 0,000 0,48687077 0,48942429 ! sulfur metabolic process GO:0006790 118 92 0,000 0,48687077 0,48921047 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,49058867 0,49273098 ! electron transport chain GO:0022900 123 94 0,000 0,49427984 0,49622158 ! carboxylic acid transport GO:0046942 147 95 0,000 0,49794448 0,49968251 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,50158277 0,50311399 ! protein maturation GO:0051604 129 96 0,000 0,50158277 0,50289467 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,50519491 0,50629555 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,51234145 0,51323403 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,51587622 0,51654998 ! divalent metal ion transport GO:0070838 171 100 0,000 0,51587622 0,5163252 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,51587622 0,51610061 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,51587622 0,51587622