pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6252-VanDeVijver-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/vantveer-oligo_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! response to hormone stimulus GO:0009725 102 100 8,000 5,253E-08 9,681E-05 ! response to corticosteroid stimulus GO:0031960 13 13 3,000 2,132E-06 1,965E-03 GO:0051384|response to glucocorticoid stimulus, ! endocrine pancreas development GO:0031018 5 5 2,000 4,271E-06 2,624E-03 ! response to steroid hormone stimulus GO:0048545 35 35 4,000 6,097E-06 2,809E-03 ! focal adhesion formation GO:0048041 7 6 2,000 8,495E-06 3,131E-03 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 7 7 2,000 1,479E-05 4,542E-03 ! oxaloacetate metabolic process GO:0006107 7 7 2,000 1,479E-05 3,893E-03 ! membrane protein ectodomain proteolysis GO:0006509 7 7 2,000 1,479E-05 3,406E-03 GO:0033619|membrane protein proteolysis, ! pancreas development GO:0031016 8 8 2,000 2,353E-05 4,818E-03 ! branched chain family amino acid metabolic process GO:0009081 8 8 2,000 2,353E-05 4,336E-03 ! cellular response to hormone stimulus GO:0032870 48 46 4,000 2,415E-05 4,046E-03 ! positive regulation of protein kinase cascade GO:0010740 79 78 5,000 2,628E-05 4,036E-03 ! gland development GO:0048732 51 49 4,000 3,301E-05 4,68E-03 ! defense response to virus GO:0051607 9 9 2,000 3,51E-05 4,621E-03 ! epidermis morphogenesis GO:0048730 10 10 2,000 4,987E-05 6,127E-03 ! cell-substrate junction assembly GO:0007044 11 10 2,000 4,987E-05 5,744E-03 ! gland morphogenesis GO:0022612 10 10 2,000 4,987E-05 5,407E-03 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 11 11 2,000 6,82E-05 6,983E-03 ! regulation of viral genome replication GO:0045069 11 11 2,000 6,82E-05 6,615E-03 ! regulation of protein localization GO:0032880 58 57 4,000 6,918E-05 6,375E-03 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 12 12 2,000 9,044E-05 7,937E-03 ! positive regulation of multicellular organism growth GO:0040018 12 12 2,000 9,044E-05 7,576E-03 ! positive regulation of JAK-STAT cascade GO:0046427 13 13 2,000 1,169E-04 9,37E-03 ! regulation of viral reproduction GO:0050792 13 13 2,000 1,169E-04 8,979E-03 ! tissue homeostasis GO:0001894 13 13 2,000 1,169E-04 8,62E-03 GO:0048871|multicellular organismal homeostasis, ! regulation of angiogenesis GO:0045765 35 34 3,000 1,227E-04 8,696E-03 ! regulation of protein catabolic process GO:0042176 35 34 3,000 1,227E-04 8,374E-03 ! positive regulation of epithelial cell proliferation GO:0050679 14 14 2,000 1,48E-04 9,742E-03 ! response to organic cyclic substance GO:0014070 15 14 2,000 1,48E-04 9,406E-03 ! positive regulation of inflammatory response GO:0050729 14 14 2,000 1,48E-04 9,093E-03 ! leukocyte homeostasis GO:0001776 15 15 2,000 1,84E-04 0,01093936 ! chromosome segregation GO:0007059 38 38 3,000 1,909E-04 0,01099293 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 16 16 2,000 2,252E-04 0,01257908 ! dicarboxylic acid metabolic process GO:0043648 18 17 2,000 2,72E-04 0,01474477 ! cell junction assembly GO:0034329 18 17 2,000 2,72E-04 0,01432349 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 42 42 3,000 2,829E-04 0,01448355 ! meiosis I GO:0007127 18 18 2,000 3,246E-04 0,01617075 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 45 44 3,000 3,392E-04 0,01645314 ! phosphoinositide-mediated signaling GO:0048015 45 45 3,000 3,702E-04 0,01749548 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 46 45 3,000 3,702E-04 0,0170581 ! regulation of JAK-STAT cascade GO:0046425 19 19 2,000 3,834E-04 0,01723519 ! regulation of protein stability GO:0031647 19 19 2,000 3,834E-04 0,01682483 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 47 46 3,000 4,032E-04 0,01728067 ! positive regulation of ligase activity GO:0051351 47 46 3,000 4,032E-04 0,01688793 ! regulation of catabolic process GO:0009894 48 47 3,000 4,382E-04 0,01794635 ! actin filament organization GO:0007015 50 48 3,000 4,753E-04 0,01904364 ! regulation of ubiquitin-protein ligase activity GO:0051438 49 48 3,000 4,753E-04 0,01863845 ! regulation of anatomical structure morphogenesis GO:0022603 90 86 4,000 4,861E-04 0,01866551 ! regulation of ligase activity GO:0051340 50 49 3,000 5,146E-04 0,01935647 ! regulation of multicellular organism growth GO:0040014 21 21 2,000 5,206E-04 0,01918794 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 21 21 2,000 5,206E-04 0,01881171 ! negative regulation of protein transport GO:0051224 21 21 2,000 5,206E-04 0,01844995 ! regulation of defense response GO:0031347 50 50 3,000 5,562E-04 0,01934148 ! negative regulation of transport GO:0051051 51 50 3,000 5,562E-04 0,01898331 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 50 50 3,000 5,562E-04 0,01863816 ! prostate gland development GO:0030850 5 5 1,000 5,737E-04 0,01888207 ! metencephalon development GO:0022037 5 5 1,000 5,737E-04 0,0185508 ! 2-oxoglutarate metabolic process GO:0006103 5 5 1,000 5,737E-04 0,01823096 ! dopamine receptor signaling pathway GO:0007212 5 5 1,000 5,737E-04 0,01792196 ! amyloid precursor protein catabolic process GO:0042987 5 5 1,000 5,737E-04 0,01762326 ! insulin-like growth factor receptor signaling pathway GO:0048009 5 5 1,000 5,737E-04 0,01733436 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 5 5 1,000 5,737E-04 0,01705477 GO:0033135|regulation of peptidyl-serine phosphorylation, ! tyrosine metabolic process GO:0006570 5 5 1,000 5,737E-04 0,01678406 ! receptor clustering GO:0043113 5 5 1,000 5,737E-04 0,01652181 ! fear response GO:0042596 5 5 1,000 5,737E-04 0,01626763 ! actin cytoskeleton reorganization GO:0031532 5 5 1,000 5,737E-04 0,01602115 ! regulation of vascular endothelial growth factor production GO:0010574 5 5 1,000 5,737E-04 0,01578203 ! response to UV-B GO:0010224 5 5 1,000 5,737E-04 0,01554994 ! regulation of mitochondrial membrane potential GO:0051881 5 5 1,000 5,737E-04 0,01532458 ! positive regulation of interleukin-6 production GO:0032755 5 5 1,000 5,737E-04 0,01510566 ! postreplication repair GO:0006301 5 5 1,000 5,737E-04 0,0148929 ! cellular pigmentation GO:0033059 5 5 1,000 5,737E-04 0,01468605 ! DNA methylation GO:0006306 5 5 1,000 5,737E-04 0,01448487 GO:0006305|DNA alkylation, ! T cell lineage commitment GO:0002360 5 5 1,000 5,737E-04 0,01428913 ! peptidyl-histidine modification GO:0018202 5 5 1,000 5,737E-04 0,01409861 ! positive regulation of leukocyte chemotaxis GO:0002690 5 5 1,000 5,737E-04 0,0139131 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper cell differentiation GO:0045624 5 5 1,000 5,737E-04 0,01373241 GO:0045622|regulation of T-helper cell differentiation, ! oocyte differentiation GO:0009994 5 5 1,000 5,737E-04 0,01355636 GO:0048599|oocyte development, ! regulation of protein homodimerization activity GO:0043496 6 5 1,000 5,737E-04 0,01338476 ! spleen development GO:0048536 5 5 1,000 5,737E-04 0,01321745 ! positive regulation of viral reproduction GO:0048524 5 5 1,000 5,737E-04 0,01305427 ! myeloid cell homeostasis GO:0002262 5 5 1,000 5,737E-04 0,01289507 ! cardiac cell differentiation GO:0035051 6 5 1,000 5,737E-04 0,01273971 ! response to nicotine GO:0035094 5 5 1,000 5,737E-04 0,01258805 ! mitochondrion localization GO:0051646 5 5 1,000 5,737E-04 0,01243995 ! cellular amide metabolic process GO:0043603 22 22 2,000 5,995E-04 0,01284711 ! cell junction organization GO:0034330 23 22 2,000 5,995E-04 0,01269944 ! hormone-mediated signaling GO:0009755 22 22 2,000 5,995E-04 0,01255513 ! regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 52 52 3,000 6,465E-04 0,0133867 ! fatty acid metabolic process GO:0006631 93 92 4,000 6,629E-04 0,01357559 ! response to estrogen stimulus GO:0043627 23 23 2,000 6,857E-04 0,01388664 ! endocrine system development GO:0035270 23 23 2,000 6,857E-04 0,0137357 ! positive regulation of growth GO:0045927 23 23 2,000 6,857E-04 0,013588 ! regulation of protein transport GO:0051223 53 53 3,000 6,953E-04 0,01363163 GO:0070201|regulation of establishment of protein localization, ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 6 6 1,000 8,564E-04 0,01661332 ! regulation of chemokine biosynthetic process GO:0045073 6 6 1,000 8,564E-04 0,01644026 ! L-phenylalanine metabolic process GO:0006558 6 6 1,000 8,564E-04 0,01627078 GO:0006559|L-phenylalanine catabolic process, ! peptidyl-serine phosphorylation GO:0018105 6 6 1,000 8,564E-04 0,01610475 ! negative regulation of ossification GO:0030279 6 6 1,000 8,564E-04 0,01594207 ! phosphoinositide 3-kinase cascade GO:0014065 6 6 1,000 8,564E-04 0,01578265 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 6 6 1,000 8,564E-04 0,01562639 GO:0043372|positive regulation of CD4-positive, alpha beta T cell differentiation, ! protein sumoylation GO:0016925 6 6 1,000 8,564E-04 0,01547319 ! regulation of T-helper 2 type immune response GO:0002828 6 6 1,000 8,564E-04 0,01532296 ! succinate metabolic process GO:0006105 7 6 1,000 8,564E-04 0,01517563 ! positive regulation of transcription factor import into nucleus GO:0042993 6 6 1,000 8,564E-04 0,0150311 ! negative regulation of T cell proliferation GO:0042130 6 6 1,000 8,564E-04 0,0148893 GO:0070667|negative regulation of mast cell proliferation, ! DNA unwinding during replication GO:0006268 6 6 1,000 8,564E-04 0,01475014 ! regulation of T cell differentiation in the thymus GO:0033081 6 6 1,000 8,564E-04 0,01461357 ! salivary gland morphogenesis GO:0007435 6 6 1,000 8,564E-04 0,0144795 ! thymus development GO:0048538 6 6 1,000 8,564E-04 0,01434787 ! regulation of intracellular protein transport GO:0033157 25 25 2,000 8,808E-04 0,01462515 ! regulation of T cell proliferation GO:0042129 25 25 2,000 8,808E-04 0,01449457 ! icosanoid metabolic process GO:0006690 25 25 2,000 8,808E-04 0,0143663 ! regulation of binding GO:0051098 60 57 3,000 9,168E-04 0,01482188 ! positive regulation of defense response GO:0031349 26 26 2,000 9,903E-04 0,0158712 ! regulation of T cell differentiation GO:0045580 26 26 2,000 9,903E-04 0,01573438 ! peptidyl-amino acid modification GO:0018193 61 59 3,000 1,044E-03 0,01645183 ! regulation of nucleocytoplasmic transport GO:0046822 27 27 2,000 1,108E-03 0,01730683 ! proteasomal protein catabolic process GO:0010498 62 61 3,000 1,184E-03 0,01833754 GO:0043161|proteasomal ubiquitin-dependent protein catabolic process, ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 7 7 1,000 1,193E-03 0,01832226 ! regulation of chemokine production GO:0032642 7 7 1,000 1,193E-03 0,01817084 ! double-strand break repair via homologous recombination GO:0000724 7 7 1,000 1,193E-03 0,0180219 GO:0000725|recombinational repair, ! hair follicle morphogenesis GO:0031069 7 7 1,000 1,193E-03 0,01787538 ! amyloid precursor protein metabolic process GO:0042982 7 7 1,000 1,193E-03 0,01773122 ! digestive system development GO:0055123 7 7 1,000 1,193E-03 0,01758937 GO:0048546|digestive tract morphogenesis, GO:0048547|gut morphogenesis, ! regulation of mRNA processing GO:0050684 7 7 1,000 1,193E-03 0,01744977 ! regulation of skeletal muscle fiber development GO:0048742 7 7 1,000 1,193E-03 0,01731237 ! negative regulation of lymphocyte proliferation GO:0050672 7 7 1,000 1,193E-03 0,01717712 GO:0032945|negative regulation of mononuclear cell proliferation, GO:0070664|negative regulation of leukocyte proliferation, ! alpha-beta T cell differentiation GO:0046632 7 7 1,000 1,193E-03 0,01704396 ! response to estradiol stimulus GO:0032355 7 7 1,000 1,193E-03 0,01691286 ! platelet activation GO:0030168 8 7 1,000 1,193E-03 0,01678375 ! response to gamma radiation GO:0010332 8 7 1,000 1,193E-03 0,0166566 ! positive regulation of acute inflammatory response GO:0002675 7 7 1,000 1,193E-03 0,01653136 ! negative regulation of T cell activation GO:0050868 7 7 1,000 1,193E-03 0,01640799 ! unsaturated fatty acid metabolic process GO:0033559 28 28 2,000 1,234E-03 0,01685093 ! regulation of mast cell proliferation GO:0070666 28 28 2,000 1,234E-03 0,01672702 ! phosphoinositide metabolic process GO:0030384 29 29 2,000 1,369E-03 0,01842054 ! regulation of epithelial cell proliferation GO:0050678 29 29 2,000 1,369E-03 0,01828705 ! regulation of lymphocyte proliferation GO:0050670 29 29 2,000 1,369E-03 0,01815549 GO:0032944|regulation of mononuclear cell proliferation, GO:0070663|regulation of leukocyte proliferation, ! positive regulation of protein transport GO:0051222 29 29 2,000 1,369E-03 0,01802581 ! response to UV GO:0009411 29 29 2,000 1,369E-03 0,01789797 ! positive regulation of protein metabolic process GO:0051247 64 64 3,000 1,417E-03 0,0183945 ! response to reactive oxygen species GO:0000302 31 30 2,000 1,513E-03 0,01950229 ! positive regulation of response to external stimulus GO:0032103 30 30 2,000 1,513E-03 0,01936685 ! positive regulation of protein amino acid phosphorylation GO:0001934 30 30 2,000 1,513E-03 0,01923329 ! regulation of ossification GO:0030278 30 30 2,000 1,513E-03 0,01910155 ! regulation of inflammatory response GO:0050727 30 30 2,000 1,513E-03 0,01897161 ! regulation of skeletal muscle tissue development GO:0048641 8 8 1,000 1,583E-03 0,01971019 ! positive regulation of translation GO:0045727 8 8 1,000 1,583E-03 0,0195779 ! negative regulation of bone remodeling GO:0046851 8 8 1,000 1,583E-03 0,01944738 ! T cell selection GO:0045058 8 8 1,000 1,583E-03 0,01931859 ! DNA duplex unwinding GO:0032508 8 8 1,000 1,583E-03 0,0191915 GO:0032392|DNA geometric change, ! phosphagen metabolic process GO:0006599 8 8 1,000 1,583E-03 0,01906606 GO:0006600|creatine metabolic process, ! NAD metabolic process GO:0019674 8 8 1,000 1,583E-03 0,01894226 ! negative regulation of mitotic cell cycle GO:0045930 9 8 1,000 1,583E-03 0,01882005 ! alpha-beta T cell activation GO:0046631 8 8 1,000 1,583E-03 0,01869941 ! salivary gland development GO:0007431 8 8 1,000 1,583E-03 0,0185803 ! T cell homeostasis GO:0043029 8 8 1,000 1,583E-03 0,01846271 ! peptidyl-serine modification GO:0018209 8 8 1,000 1,583E-03 0,01834659 ! regulation of acute inflammatory response GO:0002673 8 8 1,000 1,583E-03 0,01823192 ! positive regulation of leukocyte migration GO:0002687 8 8 1,000 1,583E-03 0,01811868 ! regulation of immunoglobulin production GO:0002637 8 8 1,000 1,583E-03 0,01800684 ! release of cytochrome c from mitochondria GO:0001836 9 8 1,000 1,583E-03 0,01789636 ! peptide hormone secretion GO:0030072 8 8 1,000 1,583E-03 0,01778724 ! cytoplasmic sequestering of protein GO:0051220 8 8 1,000 1,583E-03 0,01767944 ! regulation of intracellular transport GO:0032386 31 31 2,000 1,666E-03 0,01849946 ! regulation of cell size GO:0008361 68 68 3,000 1,776E-03 0,01959778 ! negative regulation of cell growth GO:0030308 32 32 2,000 1,829E-03 0,02006099 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 32 32 2,000 1,829E-03 0,01994229 ! regulation of lymphocyte differentiation GO:0045619 32 32 2,000 1,829E-03 0,01982498 ! regulation of mitotic cell cycle GO:0007346 72 69 3,000 1,874E-03 0,02020231 ! wound healing GO:0042060 74 70 3,000 1,977E-03 0,02118171 ! negative regulation of cell size GO:0045792 33 33 2,000 2,001E-03 0,02131333 ! negative regulation of cell cycle process GO:0010948 9 9 1,000 2,025E-03 0,02144876 ! negative regulation of cytokine biosynthetic process GO:0042036 9 9 1,000 2,025E-03 0,02132619 ! response to alkaloid GO:0043279 10 9 1,000 2,025E-03 0,02120502 ! response to ethanol GO:0045471 9 9 1,000 2,025E-03 0,02108522 ! activation of pro-apoptotic gene products GO:0008633 9 9 1,000 2,025E-03 0,02096676 ! branching involved in ureteric bud morphogenesis GO:0001658 9 9 1,000 2,025E-03 0,02084963 GO:0060675|ureteric bud morphogenesis, ! peptide secretion GO:0002790 9 9 1,000 2,025E-03 0,0207338 ! positive regulation of alpha-beta T cell differentiation GO:0046638 9 9 1,000 2,025E-03 0,02061925 ! ventricular cardiac muscle morphogenesis GO:0055010 9 9 1,000 2,025E-03 0,02050595 ! positive regulation of protein import into nucleus GO:0042307 9 9 1,000 2,025E-03 0,0203939 ! prostaglandin metabolic process GO:0006693 9 9 1,000 2,025E-03 0,02028306 GO:0006692|prostanoid metabolic process, ! T cell differentiation in the thymus GO:0033077 9 9 1,000 2,025E-03 0,02017343 ! negative regulation of tissue remodeling GO:0034104 9 9 1,000 2,025E-03 0,02006497 ! regulation of leukocyte migration GO:0002685 9 9 1,000 2,025E-03 0,01995767 ! aromatic amino acid family catabolic process GO:0009074 9 9 1,000 2,025E-03 0,01985151 ! regulation of bone remodeling GO:0046850 34 34 2,000 2,182E-03 0,02128123 ! response to metal ion GO:0010038 34 34 2,000 2,182E-03 0,02116922 ! secondary metabolic process GO:0019748 34 34 2,000 2,182E-03 0,02105839 ! response to peptide hormone stimulus GO:0043434 36 34 2,000 2,182E-03 0,02094871 ! positive regulation of phosphorylation GO:0042327 35 35 2,000 2,374E-03 0,02267064 ! regulation of tissue remodeling GO:0034103 35 35 2,000 2,374E-03 0,02255378 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 10 10 1,000 2,519E-03 0,02380578 ! positive regulation of anti-apoptosis GO:0045768 10 10 1,000 2,519E-03 0,02368432 GO:0045767|regulation of anti-apoptosis, ! reciprocal meiotic recombination GO:0007131 10 10 1,000 2,519E-03 0,0235641 ! hormone secretion GO:0046879 10 10 1,000 2,519E-03 0,02344508 ! negative regulation of nucleocytoplasmic transport GO:0046823 10 10 1,000 2,519E-03 0,02332727 ! calcium-independent cell-cell adhesion GO:0016338 10 10 1,000 2,519E-03 0,02321063 ! apoptotic mitochondrial changes GO:0008637 11 10 1,000 2,519E-03 0,02309516 ! fat cell differentiation GO:0045444 10 10 1,000 2,519E-03 0,02298083 ! exocrine system development GO:0035272 10 10 1,000 2,519E-03 0,02286762 ! neuromuscular junction development GO:0007528 10 10 1,000 2,519E-03 0,02275552 ! regulation of protein binding GO:0043393 11 10 1,000 2,519E-03 0,02264452 ! regulation of alpha-beta T cell differentiation GO:0046637 10 10 1,000 2,519E-03 0,0225346 ! lymphocyte homeostasis GO:0002260 10 10 1,000 2,519E-03 0,02242573 ! gut development GO:0048565 10 10 1,000 2,519E-03 0,02231792 ! negative regulation of homeostatic process GO:0032845 10 10 1,000 2,519E-03 0,02221113 ! protein stabilization GO:0050821 10 10 1,000 2,519E-03 0,02210537 ! response to oxidative stress GO:0006979 76 75 3,000 2,547E-03 0,02224956 ! response to inorganic substance GO:0010035 36 36 2,000 2,576E-03 0,02239334 ! regulation of mitosis GO:0007088 37 36 2,000 2,576E-03 0,0222882 GO:0051783|regulation of nuclear division, ! positive regulation of cell migration GO:0030335 36 36 2,000 2,576E-03 0,02218405 ! positive regulation of phosphorus metabolic process GO:0010562 36 36 2,000 2,576E-03 0,02208087 GO:0045937|positive regulation of phosphate metabolic process, ! coagulation GO:0050817 39 36 2,000 2,576E-03 0,02197864 GO:0007596|blood coagulation, ! positive regulation of multicellular organismal process GO:0051240 76 76 3,000 2,674E-03 0,02270731 ! regulation of transcription factor activity GO:0051090 38 37 2,000 2,788E-03 0,02357039 GO:0090046|regulation of transcription regulator activity, ! meiosis GO:0007126 37 37 2,000 2,788E-03 0,02346276 GO:0051327|M phase of meiotic cell cycle, ! response to drug GO:0042493 37 37 2,000 2,788E-03 0,02335611 ! negative regulation of growth GO:0045926 37 37 2,000 2,788E-03 0,02325043 ! cell-matrix adhesion GO:0007160 39 38 2,000 3,011E-03 0,02499379 ! urogenital system development GO:0001655 38 38 2,000 3,011E-03 0,02488171 ! meiotic cell cycle GO:0051321 38 38 2,000 3,011E-03 0,02477063 ! phosphatidylinositol metabolic process GO:0046488 11 11 1,000 3,063E-03 0,02509235 ! skin development GO:0043588 11 11 1,000 3,063E-03 0,02498132 ! signal complex assembly GO:0007172 11 11 1,000 3,063E-03 0,02487127 ! positive regulation of nucleocytoplasmic transport GO:0046824 11 11 1,000 3,063E-03 0,02476219 GO:0032388|positive regulation of intracellular transport, ! apoptotic nuclear changes GO:0030262 11 11 1,000 3,063E-03 0,02465406 ! positive regulation of alpha-beta T cell activation GO:0046635 11 11 1,000 3,063E-03 0,02454687 ! cardiac muscle tissue morphogenesis GO:0055008 11 11 1,000 3,063E-03 0,0244406 GO:0060415|muscle tissue morphogenesis, ! oogenesis GO:0048477 11 11 1,000 3,063E-03 0,02433526 ! hindbrain development GO:0030902 11 11 1,000 3,063E-03 0,02423081 ! aromatic amino acid family metabolic process GO:0009072 11 11 1,000 3,063E-03 0,02412726 ! negative regulation of lymphocyte activation GO:0051250 11 11 1,000 3,063E-03 0,02402459 ! neuron projection development GO:0031175 85 80 3,000 3,222E-03 0,0251624 ! hemostasis GO:0007599 42 39 2,000 3,244E-03 0,02522585 ! positive regulation of protein modification process GO:0031401 39 39 2,000 3,244E-03 0,02511986 ! cytokine-mediated signaling pathway GO:0019221 39 39 2,000 3,244E-03 0,02501476 ! positive regulation of cell motion GO:0051272 39 39 2,000 3,244E-03 0,02491053 ! organelle localization GO:0051640 41 40 2,000 3,488E-03 0,02667369 ! positive regulation of protein catabolic process GO:0045732 12 12 1,000 3,658E-03 0,02785785 ! positive regulation of angiogenesis GO:0045766 12 12 1,000 3,658E-03 0,02774321 ! GPI anchor biosynthetic process GO:0006506 12 12 1,000 3,658E-03 0,02762951 GO:0006505|GPI anchor metabolic process, ! glycoprotein catabolic process GO:0006516 13 12 1,000 3,658E-03 0,02751674 ! acute-phase response GO:0006953 12 12 1,000 3,658E-03 0,02740488 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 12 12 1,000 3,658E-03 0,02729393 ! male gonad development GO:0008584 12 12 1,000 3,658E-03 0,02718387 ! regulation of alpha-beta T cell activation GO:0046634 12 12 1,000 3,658E-03 0,0270747 ! renal system process GO:0003014 12 12 1,000 3,658E-03 0,0269664 ! regulation of interleukin-6 production GO:0032675 12 12 1,000 3,658E-03 0,02685896 ! regulation of chromosome organization GO:0033044 12 12 1,000 3,658E-03 0,02675238 ! hormone transport GO:0009914 12 12 1,000 3,658E-03 0,02664664 ! aromatic compound catabolic process GO:0019439 13 12 1,000 3,658E-03 0,02654173 ! regulation of mitotic metaphase/anaphase transition GO:0030071 13 12 1,000 3,658E-03 0,02643765 ! cell-substrate adhesion GO:0031589 43 42 2,000 4,009E-03 0,02886306 ! negative regulation of ligase activity GO:0051352 43 42 2,000 4,009E-03 0,02875075 GO:0051444|negative regulation of ubiquitin-protein ligase activity, GO:0051436|negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ! regulation of cellular localization GO:0060341 86 85 3,000 4,01E-03 0,02864492 ! reproductive structure development GO:0048608 43 43 2,000 4,287E-03 0,03050287 ! mitochondrion organization GO:0007005 44 43 2,000 4,287E-03 0,03038555 ! homeostasis of number of cells GO:0048872 44 43 2,000 4,287E-03 0,03026913 ! positive regulation of smooth muscle cell proliferation GO:0048661 13 13 1,000 4,302E-03 0,03026017 ! negative regulation of hormone secretion GO:0046888 13 13 1,000 4,302E-03 0,03014511 ! regeneration GO:0031099 13 13 1,000 4,302E-03 0,03003092 ! post-embryonic development GO:0009791 14 13 1,000 4,302E-03 0,0299176 ! regulation of innate immune response GO:0045088 13 13 1,000 4,302E-03 0,02980513 ! mitochondrial membrane organization GO:0007006 13 13 1,000 4,302E-03 0,0296935 ! receptor metabolic process GO:0043112 14 13 1,000 4,302E-03 0,0295827 ! actin filament bundle formation GO:0051017 13 13 1,000 4,302E-03 0,02947273 ! negative regulation of protein catabolic process GO:0042177 13 13 1,000 4,302E-03 0,02936357 ! ureteric bud development GO:0001657 13 13 1,000 4,302E-03 0,02925522 ! cell aging GO:0007569 13 13 1,000 4,302E-03 0,02914766 ! coenzyme catabolic process GO:0009109 13 13 1,000 4,302E-03 0,02904089 GO:0046356|acetyl-CoA catabolic process, GO:0006099|tricarboxylic acid cycle, ! nucleotide-excision repair, DNA gap filling GO:0006297 13 13 1,000 4,302E-03 0,02893491 ! positive regulation of locomotion GO:0040017 13 13 1,000 4,302E-03 0,02882969 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, GO:0050920|regulation of chemotaxis, ! negative regulation of intracellular transport GO:0032387 13 13 1,000 4,302E-03 0,02872523 ! negative regulation of leukocyte activation GO:0002695 13 13 1,000 4,302E-03 0,02862153 ! regulation of cell-substrate adhesion GO:0010810 14 13 1,000 4,302E-03 0,02851858 GO:0001952|regulation of cell-matrix adhesion, ! response to cytokine stimulus GO:0034097 13 13 1,000 4,302E-03 0,02841636 ! alkene biosynthetic process GO:0043450 13 13 1,000 4,302E-03 0,02831487 GO:0019370|leukotriene biosynthetic process, ! humoral immune response GO:0006959 44 44 2,000 4,575E-03 0,03000912 ! vitamin metabolic process GO:0006766 44 44 2,000 4,575E-03 0,0299027 ! regulation of DNA binding GO:0051101 47 45 2,000 4,876E-03 0,03175318 ! acetyl-CoA metabolic process GO:0006084 14 14 1,000 4,994E-03 0,03240867 ! hair cycle GO:0042633 14 14 1,000 4,994E-03 0,03229495 GO:0022404|molting cycle process, GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042303|molting cycle, ! response to retinoic acid GO:0032526 14 14 1,000 4,994E-03 0,03218203 GO:0033189|response to vitamin A, ! multicellular organismal response to stress GO:0033555 14 14 1,000 4,994E-03 0,0320699 ! peptide transport GO:0015833 14 14 1,000 4,994E-03 0,03195855 ! regulation of behavior GO:0050795 14 14 1,000 4,994E-03 0,03184796 ! base-excision repair GO:0006284 14 14 1,000 4,994E-03 0,03173814 ! leukotriene metabolic process GO:0006691 14 14 1,000 4,994E-03 0,03162908 ! DNA modification GO:0006304 14 14 1,000 4,994E-03 0,03152076 ! collagen fibril organization GO:0030199 14 14 1,000 4,994E-03 0,03141318 ! positive regulation of osteoblast differentiation GO:0045669 14 14 1,000 4,994E-03 0,03130633 ! response to molecule of bacterial origin GO:0002237 14 14 1,000 4,994E-03 0,03120021 ! DNA replication GO:0006260 91 91 3,000 5,117E-03 0,03185761 ! regulation of membrane potential GO:0042391 46 46 2,000 5,188E-03 0,03219276 ! regulation of blood pressure GO:0008217 48 47 2,000 5,512E-03 0,03408755 ! sex differentiation GO:0007548 47 47 2,000 5,512E-03 0,03397354 ! tissue morphogenesis GO:0048729 94 93 3,000 5,527E-03 0,03395277 ! response to vitamin GO:0033273 15 15 1,000 5,734E-03 0,0351093 ! regulation of transcription factor import into nucleus GO:0042990 15 15 1,000 5,734E-03 0,03499304 ! striated muscle cell differentiation GO:0051146 16 15 1,000 5,734E-03 0,03487755 ! insulin receptor signaling pathway GO:0008286 17 15 1,000 5,734E-03 0,03476282 ! ovarian follicle development GO:0001541 15 15 1,000 5,734E-03 0,03464885 ! antigen processing and presentation of peptide antigen GO:0048002 15 15 1,000 5,734E-03 0,03453562 ! chromosome condensation GO:0030261 15 15 1,000 5,734E-03 0,03442312 ! response to ionizing radiation GO:0010212 16 15 1,000 5,734E-03 0,03431136 ! regulation of production of molecular mediator of immune response GO:0002700 15 15 1,000 5,734E-03 0,03420032 ! nicotinamide metabolic process GO:0006769 15 15 1,000 5,734E-03 0,03409 GO:0046496|nicotinamide nucleotide metabolic process, ! positive regulation of B cell activation GO:0050871 15 15 1,000 5,734E-03 0,03398038 ! cellular alkene metabolic process GO:0043449 15 15 1,000 5,734E-03 0,03387147 ! negative regulation of transcription factor activity GO:0043433 16 15 1,000 5,734E-03 0,03376325 GO:0090048|negative regulation of transcription regulator activity, ! negative regulation of cell activation GO:0050866 15 15 1,000 5,734E-03 0,03365573 ! protein homooligomerization GO:0051260 15 15 1,000 5,734E-03 0,03354888 ! regulation of response to stress GO:0080134 97 94 3,000 5,74E-03 0,03347665 ! regulation of cell cycle process GO:0010564 50 48 2,000 5,847E-03 0,03399651 ! glycerophospholipid metabolic process GO:0006650 49 48 2,000 5,847E-03 0,03388961 ! regulation of cell growth GO:0001558 97 96 3,000 6,183E-03 0,03571904 ! response to nutrient GO:0007584 49 49 2,000 6,195E-03 0,03568087 ! response to bacterium GO:0009617 50 49 2,000 6,195E-03 0,03556972 ! positive regulation of MAP kinase activity GO:0043406 50 49 2,000 6,195E-03 0,03545925 ! negative regulation of adenylate cyclase activity GO:0007194 16 16 1,000 6,521E-03 0,03720835 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! alkaloid metabolic process GO:0009820 16 16 1,000 6,521E-03 0,03709351 ! positive regulation of mitosis GO:0045840 16 16 1,000 6,521E-03 0,03697938 GO:0051785|positive regulation of nuclear division, ! cellular response to reactive oxygen species GO:0034614 16 16 1,000 6,521E-03 0,03686594 ! positive regulation of cell development GO:0010720 16 16 1,000 6,521E-03 0,0367532 ! lymphocyte proliferation GO:0046651 16 16 1,000 6,521E-03 0,03664115 ! positive regulation of MAPKKK cascade GO:0043410 17 16 1,000 6,521E-03 0,03652978 ! cofactor catabolic process GO:0051187 16 16 1,000 6,521E-03 0,03641908 ! positive regulation of catabolic process GO:0009896 16 16 1,000 6,521E-03 0,03630905 ! regulation of DNA metabolic process GO:0051052 51 50 2,000 6,555E-03 0,0363893 ! anatomical structure homeostasis GO:0060249 51 50 2,000 6,555E-03 0,03628003 ! posttranscriptional regulation of gene expression GO:0010608 98 98 3,000 6,647E-03 0,03667993 ! protein modification by small protein conjugation GO:0032446 52 51 2,000 6,927E-03 0,03811104 ! response to other organism GO:0051707 101 100 3,000 7,135E-03 0,03913587 ! regulation of body fluid levels GO:0050878 55 52 2,000 7,312E-03 0,03998789 ! response to light stimulus GO:0009416 53 52 2,000 7,312E-03 0,03986959 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 17 17 1,000 7,354E-03 0,03998199 ! regulation of smooth muscle cell proliferation GO:0048660 17 17 1,000 7,354E-03 0,03986439 ! positive regulation of cell adhesion GO:0045785 17 17 1,000 7,354E-03 0,03974749 ! myelination GO:0042552 17 17 1,000 7,354E-03 0,03963127 ! phosphoinositide biosynthetic process GO:0046489 17 17 1,000 7,354E-03 0,03951573 ! glucose transport GO:0015758 17 17 1,000 7,354E-03 0,03940085 ! development of primary male sexual characteristics GO:0046546 17 17 1,000 7,354E-03 0,03928665 ! response to toxin GO:0009636 18 17 1,000 7,354E-03 0,0391731 ! positive regulation of protein secretion GO:0050714 17 17 1,000 7,354E-03 0,03906021 ! regulation of osteoblast differentiation GO:0045667 17 17 1,000 7,354E-03 0,03894797 ! pyridine nucleotide metabolic process GO:0019362 17 17 1,000 7,354E-03 0,03883637 ! pigmentation GO:0043473 17 17 1,000 7,354E-03 0,03872541 ! regulation of T cell activation GO:0050863 53 53 2,000 7,709E-03 0,04047747 ! protein amino acid dephosphorylation GO:0006470 55 54 2,000 8,118E-03 0,04250679 ! response to virus GO:0009615 54 54 2,000 8,118E-03 0,04238638 ! negative regulation of multicellular organismal process GO:0051241 55 54 2,000 8,118E-03 0,04226664 ! icosanoid biosynthetic process GO:0046456 18 18 1,000 8,233E-03 0,0427418 ! epidermal growth factor receptor signaling pathway GO:0007173 18 18 1,000 8,233E-03 0,04262174 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 18 18 1,000 8,233E-03 0,04250235 ! mononuclear cell proliferation GO:0032943 18 18 1,000 8,233E-03 0,04238363 GO:0070661|leukocyte proliferation, ! hexose transport GO:0008645 18 18 1,000 8,233E-03 0,04226557 GO:0015749|monosaccharide transport, ! negative regulation of DNA binding GO:0043392 19 18 1,000 8,233E-03 0,04214817 ! B cell differentiation GO:0030183 18 18 1,000 8,233E-03 0,04203141 ! ensheathment of neurons GO:0007272 18 18 1,000 8,233E-03 0,04191531 GO:0008366|axon ensheathment, ! negative regulation of catabolic process GO:0009895 18 18 1,000 8,233E-03 0,04179984 ! regulation of cell adhesion GO:0030155 56 55 2,000 8,541E-03 0,04324307 ! protein modification by small protein conjugation or removal GO:0070647 56 55 2,000 8,541E-03 0,04312459 ! reproductive developmental process GO:0003006 56 56 2,000 8,976E-03 0,04519675 ! extracellular structure organization GO:0043062 56 56 2,000 8,976E-03 0,04507359 ! positive regulation of T cell proliferation GO:0042102 19 19 1,000 9,156E-03 0,04585681 ! regulation of striated muscle tissue development GO:0016202 20 19 1,000 9,156E-03 0,04573253 ! multicellular organismal metabolic process GO:0044236 19 19 1,000 9,156E-03 0,04560893 ! peptidyl-tyrosine phosphorylation GO:0018108 20 19 1,000 9,156E-03 0,045486 ! metanephros development GO:0001656 19 19 1,000 9,156E-03 0,04536372 ! cellular response to oxidative stress GO:0034599 19 19 1,000 9,156E-03 0,0452421 ! positive regulation of T cell differentiation GO:0045582 19 19 1,000 9,156E-03 0,04512114 ! peripheral nervous system development GO:0007422 19 19 1,000 9,156E-03 0,04500081 ! response to heat GO:0009408 19 19 1,000 9,156E-03 0,04488113 ! regulation of muscle development GO:0048634 21 20 1,000 0,01012397 0,04949196 ! negative regulation of binding GO:0051100 21 20 1,000 0,01012397 0,04936103 ! nucleus organization GO:0006997 20 20 1,000 0,01012397 0,04923079 ! unsaturated fatty acid biosynthetic process GO:0006636 20 20 1,000 0,01012397 0,04910123 ! peptidyl-tyrosine modification GO:0018212 21 20 1,000 0,01012397 0,04897236 ! female gamete generation GO:0007292 20 20 1,000 0,01012397 0,04884416 ! negative regulation of neuron apoptosis GO:0043524 21 20 1,000 0,01012397 0,04871663 ! regulation of B cell activation GO:0050864 20 20 1,000 0,01012397 0,04858976 ! dephosphorylation GO:0016311 60 59 2,000 0,01035743 0,04958115 ! immune effector process GO:0002252 59 59 2,000 0,01035743 0,04945271 ! protein polymerization GO:0051258 65 60 2,000 0,010844 0,05164208 ! mitotic sister chromatid segregation GO:0000070 21 21 1,000 0,01113485 0,05289054 ! G1/S transition of mitotic cell cycle GO:0000082 21 21 1,000 0,01113485 0,05275457 ! mammary gland development GO:0030879 23 21 1,000 0,01113485 0,05261931 ! protein amino acid lipidation GO:0006497 21 21 1,000 0,01113485 0,05248473 ! Notch signaling pathway GO:0007219 22 21 1,000 0,01113485 0,05235084 ! regulation of protein import into nucleus GO:0042306 21 21 1,000 0,01113485 0,05221763 ! regulation of action potential in neuron GO:0019228 21 21 1,000 0,01113485 0,0520851 ! regulation of proteolysis GO:0030162 21 21 1,000 0,01113485 0,05195324 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 21 21 1,000 0,01113485 0,05182204 ! cellular response to insulin stimulus GO:0032869 23 21 1,000 0,01113485 0,05169151 ! regulation of protein amino acid phosphorylation GO:0001932 62 61 2,000 0,01134365 0,05252851 ! positive regulation of cellular protein metabolic process GO:0032270 61 61 2,000 0,01134365 0,05239686 ! axonogenesis GO:0007409 66 62 2,000 0,01185645 0,0546286 ! regulation of lymphocyte activation GO:0051249 62 62 2,000 0,01185645 0,05449237 ! positive regulation of transcription factor activity GO:0051091 22 22 1,000 0,01218839 0,0558786 GO:0090047|positive regulation of transcription regulator activity, ! positive regulation of DNA metabolic process GO:0051054 23 22 1,000 0,01218839 0,05573994 ! sister chromatid segregation GO:0000819 22 22 1,000 0,01218839 0,05560197 ! odontogenesis GO:0042476 22 22 1,000 0,01218839 0,05546468 ! positive regulation of lymphocyte proliferation GO:0050671 22 22 1,000 0,01218839 0,05532807 GO:0032946|positive regulation of mononuclear cell proliferation, GO:0070665|positive regulation of leukocyte proliferation, GO:0070668|positive regulation of mast cell proliferation, ! maintenance of protein location in cell GO:0032507 23 22 1,000 0,01218839 0,05519213 ! ovulation cycle process GO:0022602 22 22 1,000 0,01218839 0,05505686 ! spindle organization GO:0007051 22 22 1,000 0,01218839 0,05492224 ! cell chemotaxis GO:0060326 23 22 1,000 0,01218839 0,05478829 GO:0030595|leukocyte chemotaxis, ! male sex differentiation GO:0046661 22 22 1,000 0,01218839 0,05465498 ! biopolymer methylation GO:0043414 22 22 1,000 0,01218839 0,05452232 GO:0032259|methylation, ! regulation of adaptive immune response GO:0002819 22 22 1,000 0,01218839 0,05439031 ! positive regulation of lymphocyte differentiation GO:0045621 22 22 1,000 0,01218839 0,05425893 ! aerobic respiration GO:0009060 22 22 1,000 0,01218839 0,05412819 ! cytokinesis GO:0000910 23 22 1,000 0,01218839 0,05399807 ! glucose metabolic process GO:0006006 63 63 2,000 0,01238246 0,05472633 ! glycerolipid metabolic process GO:0046486 65 64 2,000 0,01292173 0,0569731 ! regulation of response to external stimulus GO:0032101 65 64 2,000 0,01292173 0,05683713 ! response to hydrogen peroxide GO:0042542 24 23 1,000 0,01328388 0,05829095 ! regulation of hormone secretion GO:0046883 23 23 1,000 0,01328388 0,05815249 ! lipoprotein biosynthetic process GO:0042158 23 23 1,000 0,01328388 0,05801469 ! female gonad development GO:0008585 23 23 1,000 0,01328388 0,05787754 ! Rho protein signal transduction GO:0007266 24 23 1,000 0,01328388 0,05774103 ! regulation of MAP kinase activity GO:0043405 67 66 2,000 0,01404026 0,06088519 ! mitochondrial transport GO:0006839 24 24 1,000 0,01442066 0,06238797 ! regulation of action potential GO:0001508 24 24 1,000 0,01442066 0,06224186 ! cellular amino acid biosynthetic process GO:0008652 24 24 1,000 0,01442066 0,06209643 ! T cell differentiation GO:0030217 24 24 1,000 0,01442066 0,06195169 ! ovulation cycle GO:0042698 24 24 1,000 0,01442066 0,06180761 ! maintenance of protein location GO:0045185 25 24 1,000 0,01442066 0,06166421 ! oxidoreduction coenzyme metabolic process GO:0006733 24 24 1,000 0,01442066 0,06152147 ! epithelial tube morphogenesis GO:0060562 25 24 1,000 0,01442066 0,06137938 ! cell morphogenesis involved in neuron differentiation GO:0048667 72 67 2,000 0,01461961 0,06208281 GO:0048812|neuron projection morphogenesis, GO:0048858|cell projection morphogenesis, ! striated muscle tissue development GO:0014706 69 67 2,000 0,01461961 0,06194009 ! response to radiation GO:0009314 70 68 2,000 0,0152124 0,06430379 ! negative regulation of secretion GO:0051048 26 25 1,000 0,01559803 0,06578301 ! endosome transport GO:0016197 25 25 1,000 0,01559803 0,06563282 ! development of primary female sexual characteristics GO:0046545 25 25 1,000 0,01559803 0,06548332 GO:0046660|female sex differentiation, ! positive regulation of DNA binding GO:0043388 26 25 1,000 0,01559803 0,06533449 ! generation of a signal involved in cell-cell signaling GO:0003001 27 25 1,000 0,01559803 0,06518634 ! heart morphogenesis GO:0003007 25 25 1,000 0,01559803 0,06503886 ! negative regulation of immune system process GO:0002683 25 25 1,000 0,01559803 0,06489204 ! JAK-STAT cascade GO:0007259 26 25 1,000 0,01559803 0,06474589 ! positive regulation of cytokine production GO:0001819 25 25 1,000 0,01559803 0,0646004 ! response to nutrient levels GO:0031667 69 69 2,000 0,01581867 0,06536729 ! regulation of leukocyte activation GO:0002694 69 69 2,000 0,01581867 0,06522105 ! positive regulation of transport GO:0051050 71 70 2,000 0,01643846 0,06762517 ! cell part morphogenesis GO:0032990 75 70 2,000 0,01643846 0,06747455 ! growth GO:0040007 70 70 2,000 0,01643846 0,06732461 ! muscle tissue development GO:0060537 72 70 2,000 0,01643846 0,06717533 ! carboxylic acid biosynthetic process GO:0046394 70 70 2,000 0,01643846 0,06702671 GO:0016053|organic acid biosynthetic process, ! positive regulation of binding GO:0051099 27 26 1,000 0,01681534 0,06841209 ! glycolysis GO:0006096 26 26 1,000 0,01681534 0,0682614 ! transforming growth factor beta receptor signaling pathway GO:0007179 26 26 1,000 0,01681534 0,06811137 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 26 26 1,000 0,01681534 0,06796201 ! negative regulation of cell migration GO:0030336 26 26 1,000 0,01681534 0,06781329 ! double-strand break repair GO:0006302 27 26 1,000 0,01681534 0,06766523 ! regulation of protein secretion GO:0050708 26 26 1,000 0,01681534 0,06751781 ! germ cell development GO:0007281 27 26 1,000 0,01681534 0,06737103 ! pigment metabolic process GO:0042440 26 26 1,000 0,01681534 0,06722489 ! response to insulin stimulus GO:0032868 28 26 1,000 0,01681534 0,06707938 ! maintenance of location in cell GO:0051651 27 26 1,000 0,01681534 0,0669345 ! synapse organization GO:0050808 26 26 1,000 0,01681534 0,06679025 ! regulation of cell migration GO:0030334 71 71 2,000 0,01707179 0,06766301 ! regulation of cell activation GO:0050865 71 71 2,000 0,01707179 0,06751781 ! response to extracellular stimulus GO:0009991 72 72 2,000 0,01771869 0,06992621 ! cAMP-mediated signaling GO:0019933 27 27 1,000 0,01807192 0,07116785 ! mesenchymal cell development GO:0014031 29 27 1,000 0,01807192 0,0710161 GO:0060485|mesenchyme development, GO:0048762|mesenchymal cell differentiation, ! defense response to bacterium GO:0042742 27 27 1,000 0,01807192 0,070865 ! cell growth GO:0016049 27 27 1,000 0,01807192 0,07071455 ! carbohydrate transport GO:0008643 28 28 1,000 0,01936712 0,07562204 ! protein amino acid autophosphorylation GO:0046777 28 28 1,000 0,01936712 0,07546217 ! developmental growth GO:0048589 28 28 1,000 0,01936712 0,07530296 ! positive regulation of cell cycle GO:0045787 29 29 1,000 0,02070029 0,08031714 ! glycerophospholipid biosynthetic process GO:0046474 30 29 1,000 0,02070029 0,08014841 ! leukocyte migration GO:0050900 30 29 1,000 0,02070029 0,07998038 ! branching morphogenesis of a tube GO:0048754 29 29 1,000 0,02070029 0,07981306 ! antigen processing and presentation GO:0019882 29 29 1,000 0,02070029 0,07964643 ! DNA-dependent DNA replication GO:0006261 29 29 1,000 0,02070029 0,0794805 ! regulation of gene expression, epigenetic GO:0040029 29 29 1,000 0,02070029 0,07931526 ! cell morphogenesis involved in differentiation GO:0000904 82 77 2,000 0,02115752 0,08089896 ! regulation of protein modification process GO:0031399 79 78 2,000 0,02188625 0,08351214 ! regulation of immune response GO:0050776 78 78 2,000 0,02188625 0,08333959 ! response to temperature stimulus GO:0009266 30 30 1,000 0,0220708 0,08386904 ! water-soluble vitamin metabolic process GO:0006767 30 30 1,000 0,0220708 0,08369647 ! vesicle organization GO:0016050 30 30 1,000 0,0220708 0,08352461 ! establishment of organelle localization GO:0051656 31 30 1,000 0,0220708 0,08335345 ! regulation of locomotion GO:0040012 79 79 2,000 0,02262867 0,08528556 ! regulation of cell motion GO:0051270 79 79 2,000 0,02262867 0,0851115 ! skeletal muscle fiber development GO:0048741 31 31 1,000 0,02347801 0,08812622 ! B cell activation GO:0042113 31 31 1,000 0,02347801 0,0879471 ! lipoprotein metabolic process GO:0042157 31 31 1,000 0,02347801 0,08776871 ! aging GO:0007568 32 31 1,000 0,02347801 0,08759104 ! glycerolipid biosynthetic process GO:0045017 32 31 1,000 0,02347801 0,08741409 ! digestion GO:0007586 31 31 1,000 0,02347801 0,08723785 ! regulation of DNA replication GO:0006275 32 31 1,000 0,02347801 0,08706232 ! extracellular matrix organization GO:0030198 31 31 1,000 0,02347801 0,0868875 ! negative regulation of cell motion GO:0051271 31 31 1,000 0,02347801 0,08671337 ! muscle fiber development GO:0048747 32 32 1,000 0,0249213 0,09185991 ! glucose catabolic process GO:0006007 32 32 1,000 0,0249213 0,09167656 ! morphogenesis of a branching structure GO:0001763 32 32 1,000 0,0249213 0,09149393 ! kidney development GO:0001822 32 32 1,000 0,0249213 0,09131204 ! protein maturation by peptide bond cleavage GO:0051605 32 32 1,000 0,0249213 0,09113086 ! maintenance of location GO:0051235 33 32 1,000 0,0249213 0,0909504 ! activation of protein kinase activity GO:0032147 35 33 1,000 0,02640005 0,09615671 ! regulation of actin polymerization or depolymerization GO:0008064 33 33 1,000 0,02640005 0,09596705 ! regulation of neuron differentiation GO:0045664 34 33 1,000 0,02640005 0,09577814 ! regulation of neuron apoptosis GO:0043523 34 33 1,000 0,02640005 0,09558997 ! positive regulation of cell differentiation GO:0045597 87 85 2,000 0,02737048 0,09890942 ! positive regulation of response to stimulus GO:0048584 86 85 2,000 0,02737048 0,09871586 ! regulation of actin filament length GO:0030832 34 34 1,000 0,02791365 0,10047825 ! ear development GO:0043583 34 34 1,000 0,02791365 0,10028239 ! muscle cell differentiation GO:0042692 35 34 1,000 0,02791365 0,10008728 ! positive regulation of protein kinase activity GO:0045860 89 86 2,000 0,02820863 0,10094854 ! organophosphate metabolic process GO:0019637 87 86 2,000 0,02820863 0,10075291 GO:0006644|phospholipid metabolic process, ! hexose metabolic process GO:0019318 87 86 2,000 0,02820863 0,10055803 ! heart development GO:0007507 90 87 2,000 0,02906041 0,10339447 ! acute inflammatory response GO:0002526 35 35 1,000 0,02946151 0,10461957 ! regulation of cyclin-dependent protein kinase activity GO:0000079 35 35 1,000 0,02946151 0,10441838 ! regulation of cellular component size GO:0032535 35 35 1,000 0,02946151 0,10421796 ! regulation of cytokine biosynthetic process GO:0042035 35 35 1,000 0,02946151 0,10401831 ! multicellular organism reproduction GO:0032504 36 35 1,000 0,02946151 0,10381942 GO:0048609|reproductive process in a multicellular organism, ! regulation of immune effector process GO:0002697 35 35 1,000 0,02946151 0,10362129 ! positive regulation of transferase activity GO:0051347 91 88 2,000 0,02992582 0,10505387 GO:0033674|positive regulation of kinase activity, ! chemotaxis GO:0006935 90 89 2,000 0,03080483 0,10793405 GO:0042330|taxis, ! oxygen and reactive oxygen species metabolic process GO:0006800 37 36 1,000 0,03104301 0,10856219 ! female pregnancy GO:0007565 37 36 1,000 0,03104301 0,10835658 ! positive regulation of organelle organization GO:0010638 36 36 1,000 0,03104301 0,10815174 ! gonad development GO:0008406 36 36 1,000 0,03104301 0,10794768 ! regulation of adenylate cyclase activity GO:0045761 37 37 1,000 0,03265758 0,11334826 GO:0031279|regulation of cyclase activity, GO:0051339|regulation of lyase activity, ! cellular amino acid catabolic process GO:0009063 38 37 1,000 0,03265758 0,1131352 ! regulation of Rho protein signal transduction GO:0035023 37 37 1,000 0,03265758 0,11292294 ! positive regulation of secretion GO:0051047 39 38 1,000 0,03430464 0,11839596 ! hexose catabolic process GO:0019320 38 38 1,000 0,03430464 0,11817466 ! axon guidance GO:0007411 39 38 1,000 0,03430464 0,11795418 ! regulation of homeostatic process GO:0032844 38 38 1,000 0,03430464 0,11773453 ! epidermis development GO:0008544 94 94 2,000 0,03540323 0,12127908 ! regulation of cAMP biosynthetic process GO:0030817 39 39 1,000 0,03598359 0,12303852 ! activation of MAPK activity GO:0000187 39 39 1,000 0,03598359 0,12281067 ! fatty acid biosynthetic process GO:0006633 39 39 1,000 0,03598359 0,12258366 ! nucleotide-excision repair GO:0006289 40 39 1,000 0,03598359 0,1223575 ! regulation of MAPKKK cascade GO:0043408 41 39 1,000 0,03598359 0,12213216 ! positive regulation of T cell activation GO:0050870 39 39 1,000 0,03598359 0,12190765 ! lymphocyte differentiation GO:0030098 39 39 1,000 0,03598359 0,12168397 ! protein oligomerization GO:0051259 39 39 1,000 0,03598359 0,1214611 ! regulation of cAMP metabolic process GO:0030814 40 40 1,000 0,03769389 0,12700153 ! intracellular receptor-mediated signaling pathway GO:0030522 40 40 1,000 0,03769389 0,12676977 ! rRNA transcription GO:0009303 5 5 0,000 0,03793942 0,12736311 ! positive regulation of protein ubiquitination GO:0031398 5 5 0,000 0,03793942 0,12713154 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 5 5 0,000 0,03793942 0,12690082 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 5 5 0,000 0,03793942 0,12667092 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! neuron fate specification GO:0048665 5 5 0,000 0,03793942 0,12644186 ! hemoglobin biosynthetic process GO:0042541 5 5 0,000 0,03793942 0,12621363 ! reproductive cellular process GO:0048610 5 5 0,000 0,03793942 0,12598621 ! positive regulation of glucose metabolic process GO:0010907 5 5 0,000 0,03793942 0,12575962 ! negative regulation of blood pressure GO:0045776 6 5 0,000 0,03793942 0,12553384 ! water transport GO:0006833 5 5 0,000 0,03793942 0,12530887 GO:0042044|fluid transport, ! forebrain regionalization GO:0021871 5 5 0,000 0,03793942 0,1250847 ! DNA synthesis during DNA repair GO:0000731 5 5 0,000 0,03793942 0,12486134 ! positive regulation of B cell proliferation GO:0030890 5 5 0,000 0,03793942 0,12463877 ! glycerol metabolic process GO:0006071 5 5 0,000 0,03793942 0,12441699 ! regulation of cellular amine metabolic process GO:0033238 5 5 0,000 0,03793942 0,124196 GO:0042053|regulation of dopamine metabolic process, GO:0042069|regulation of catecholamine metabolic process, ! meiotic prophase I GO:0007128 5 5 0,000 0,03793942 0,1239758 GO:0051324|prophase, ! cell volume homeostasis GO:0006884 5 5 0,000 0,03793942 0,12375637 ! regulation of epidermal growth factor receptor activity GO:0007176 5 5 0,000 0,03793942 0,12353772 GO:0010469|regulation of receptor activity, ! regulation of long-term neuronal synaptic plasticity GO:0048169 5 5 0,000 0,03793942 0,12331984 ! filopodium assembly GO:0046847 7 5 0,000 0,03793942 0,12310273 GO:0030035|microspike assembly, ! CTP metabolic process GO:0046036 5 5 0,000 0,03793942 0,12288638 GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, GO:0006241|CTP biosynthetic process, ! Golgi to endosome transport GO:0006895 5 5 0,000 0,03793942 0,12267079 ! GTP metabolic process GO:0046039 5 5 0,000 0,03793942 0,12245595 ! establishment of tissue polarity GO:0007164 5 5 0,000 0,03793942 0,12224187 ! mRNA stabilization GO:0048255 5 5 0,000 0,03793942 0,12202853 GO:0043489|RNA stabilization, ! positive regulation of cell-cell adhesion GO:0022409 5 5 0,000 0,03793942 0,12181594 ! regulation of neurotransmitter secretion GO:0046928 5 5 0,000 0,03793942 0,12160409 GO:0001956|positive regulation of neurotransmitter secretion, ! neurotransmitter uptake GO:0001504 5 5 0,000 0,03793942 0,12139297 ! social behavior GO:0035176 5 5 0,000 0,03793942 0,12118258 ! macrophage chemotaxis GO:0048246 6 5 0,000 0,03793942 0,12097292 ! memory GO:0007613 5 5 0,000 0,03793942 0,12076399 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 5 5 0,000 0,03793942 0,12055577 ! membrane hyperpolarization GO:0060081 5 5 0,000 0,03793942 0,12034828 ! response to lipid GO:0033993 5 5 0,000 0,03793942 0,12014149 ! erythrocyte maturation GO:0043249 5 5 0,000 0,03793942 0,11993542 ! hippocampus development GO:0021766 6 5 0,000 0,03793942 0,11973005 ! regulation of carbohydrate biosynthetic process GO:0043255 5 5 0,000 0,03793942 0,11952538 ! glucocorticoid metabolic process GO:0008211 5 5 0,000 0,03793942 0,11932142 ! middle ear morphogenesis GO:0042474 5 5 0,000 0,03793942 0,11911814 ! mechanosensory behavior GO:0007638 5 5 0,000 0,03793942 0,11891556 ! heart looping GO:0001947 5 5 0,000 0,03793942 0,11871367 ! negative regulation of endocytosis GO:0045806 5 5 0,000 0,03793942 0,11851246 ! response to interferon-gamma GO:0034341 5 5 0,000 0,03793942 0,11831193 ! pseudouridine synthesis GO:0001522 5 5 0,000 0,03793942 0,11811208 ! pH reduction GO:0045851 5 5 0,000 0,03793942 0,1179129 GO:0051452|intracellular pH reduction, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 5 5 0,000 0,03793942 0,11771439 ! lipopolysaccharide metabolic process GO:0008653 5 5 0,000 0,03793942 0,11751655 ! positive regulation of chemokine biosynthetic process GO:0045080 5 5 0,000 0,03793942 0,11731938 ! sphingoid biosynthetic process GO:0046520 5 5 0,000 0,03793942 0,11712286 GO:0046513|ceramide biosynthetic process, ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 5 5 0,000 0,03793942 0,11692701 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! thymic T cell selection GO:0045061 5 5 0,000 0,03793942 0,1167318 ! photoreceptor cell maintenance GO:0045494 5 5 0,000 0,03793942 0,11653725 ! adrenal gland development GO:0030325 5 5 0,000 0,03793942 0,11634334 ! regulation of cardiac muscle hypertrophy GO:0010611 5 5 0,000 0,03793942 0,11615008 GO:0010612|regulation of cardiac muscle adaptation, GO:0014743|regulation of muscle hypertrophy, GO:0043502|regulation of muscle adaptation, ! melanocyte differentiation GO:0030318 5 5 0,000 0,03793942 0,11595746 GO:0050931|pigment cell differentiation, ! ovulation GO:0030728 5 5 0,000 0,03793942 0,11576548 ! astrocyte differentiation GO:0048708 5 5 0,000 0,03793942 0,11557413 ! mitochondrial respiratory chain complex assembly GO:0033108 5 5 0,000 0,03793942 0,11538341 GO:0032981|mitochondrial respiratory chain complex I assembly, GO:0010257|NADH dehydrogenase complex assembly, ! pituitary gland development GO:0021983 5 5 0,000 0,03793942 0,11519333 ! cytoskeletal anchoring at plasma membrane GO:0007016 6 5 0,000 0,03793942 0,11500386 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 5 5 0,000 0,03793942 0,11481502 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, GO:0009164|nucleoside catabolic process, ! microtubule nucleation GO:0007020 5 5 0,000 0,03793942 0,1146268 ! regulation of interleukin-6 biosynthetic process GO:0045408 5 5 0,000 0,03793942 0,1144392 ! regulation of interleukin-8 biosynthetic process GO:0045414 5 5 0,000 0,03793942 0,1142522 ! indolalkylamine metabolic process GO:0006586 5 5 0,000 0,03793942 0,11406582 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! muscle cell migration GO:0014812 5 5 0,000 0,03793942 0,11388005 ! phasic smooth muscle contraction GO:0014821 5 5 0,000 0,03793942 0,11369488 ! central nervous system neuron axonogenesis GO:0021955 6 5 0,000 0,03793942 0,11351031 GO:0021952|central nervous system projection neuron axonogenesis, ! sister chromatid cohesion GO:0007062 5 5 0,000 0,03793942 0,11332634 ! response to ATP GO:0033198 5 5 0,000 0,03793942 0,11314296 ! regulation of type I interferon production GO:0032479 5 5 0,000 0,03793942 0,11296018 ! regulation of appetite GO:0032098 5 5 0,000 0,03793942 0,11277798 GO:0032095|regulation of response to food, ! vesicle fusion GO:0006906 5 5 0,000 0,03793942 0,11259638 ! paraxial mesoderm development GO:0048339 5 5 0,000 0,03793942 0,11241535 ! regulation of phospholipase A2 activity GO:0032429 5 5 0,000 0,03793942 0,11223491 ! regulation of the force of heart contraction GO:0002026 5 5 0,000 0,03793942 0,11205505 ! maintenance of protein location in nucleus GO:0051457 5 5 0,000 0,03793942 0,11187576 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03793942 0,11169704 ! neurotransmitter biosynthetic process GO:0042136 6 5 0,000 0,03793942 0,1115189 ! lens development in camera-type eye GO:0002088 5 5 0,000 0,03793942 0,11134132 ! retinol metabolic process GO:0042572 5 5 0,000 0,03793942 0,11116431 ! corticosteroid receptor signaling pathway GO:0031958 5 5 0,000 0,03793942 0,11098786 GO:0042921|glucocorticoid receptor signaling pathway, ! temperature homeostasis GO:0001659 5 5 0,000 0,03793942 0,11081196 ! positive regulation of exocytosis GO:0045921 6 5 0,000 0,03793942 0,11063663 ! parturition GO:0007567 5 5 0,000 0,03793942 0,11046185 ! cellular glucose homeostasis GO:0001678 5 5 0,000 0,03793942 0,11028762 ! Schwann cell differentiation GO:0014037 5 5 0,000 0,03793942 0,11011394 ! acyl-CoA metabolic process GO:0006637 5 5 0,000 0,03793942 0,1099408 ! wound healing, spreading of epidermal cells GO:0035313 5 5 0,000 0,03793942 0,10976821 ! protein heterooligomerization GO:0051291 5 5 0,000 0,03793942 0,10959616 ! regulation of gliogenesis GO:0014013 5 5 0,000 0,03793942 0,10942465 GO:0045685|regulation of glial cell differentiation, ! positive regulation of peptide secretion GO:0002793 5 5 0,000 0,03793942 0,10925367 ! oligodendrocyte development GO:0014003 5 5 0,000 0,03793942 0,10908323 ! hyaluronan metabolic process GO:0030212 5 5 0,000 0,03793942 0,10891332 ! activated T cell proliferation GO:0050798 5 5 0,000 0,03793942 0,10874393 ! interaction with symbiont GO:0051702 5 5 0,000 0,03793942 0,10857508 ! cellular extravasation GO:0045123 5 5 0,000 0,03793942 0,10840674 ! positive regulation of axonogenesis GO:0050772 5 5 0,000 0,03793942 0,10823893 ! peptidyl-asparagine modification GO:0018196 5 5 0,000 0,03793942 0,10807164 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! positive regulation of phagocytosis GO:0050766 5 5 0,000 0,03793942 0,10790486 ! regulation of insulin receptor signaling pathway GO:0046626 5 5 0,000 0,03793942 0,1077386 ! antigen processing and presentation of exogenous antigen GO:0019884 5 5 0,000 0,03793942 0,10757285 ! enucleate erythrocyte differentiation GO:0043353 6 5 0,000 0,03793942 0,1074076 ! response to amine stimulus GO:0014075 5 5 0,000 0,03793942 0,10724287 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 5 5 0,000 0,03793942 0,10707864 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 5 5 0,000 0,03793942 0,10691491 ! synaptic vesicle exocytosis GO:0016079 6 5 0,000 0,03793942 0,10675168 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 5 5 0,000 0,03793942 0,10658895 ! glycosylceramide metabolic process GO:0006677 5 5 0,000 0,03793942 0,10642671 ! neuron recognition GO:0008038 5 5 0,000 0,03793942 0,10626497 ! negative regulation of focal adhesion formation GO:0051895 6 5 0,000 0,03793942 0,10610372 ! decidualization GO:0046697 5 5 0,000 0,03793942 0,10594295 ! hair follicle maturation GO:0048820 5 5 0,000 0,03793942 0,10578268 ! phosphatidylinositol biosynthetic process GO:0006661 5 5 0,000 0,03793942 0,10562288 ! purine deoxyribonucleotide metabolic process GO:0009151 5 5 0,000 0,03793942 0,10546357 GO:0009155|purine deoxyribonucleotide catabolic process, ! regulation of interleukin-12 production GO:0032655 5 5 0,000 0,03793942 0,10530474 ! positive regulation of monooxygenase activity GO:0032770 5 5 0,000 0,03793942 0,10514639 ! spinal cord motor neuron differentiation GO:0021522 5 5 0,000 0,03793942 0,10498851 GO:0021517|ventral spinal cord development, ! histone methylation GO:0016571 5 5 0,000 0,03793942 0,10483111 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03793942 0,10467418 ! positive regulation of immunoglobulin mediated immune response GO:0002891 5 5 0,000 0,03793942 0,10451771 GO:0002714|positive regulation of B cell mediated immunity, ! positive regulation of interferon-gamma production GO:0032729 5 5 0,000 0,03793942 0,10436172 ! negative regulation of tumor necrosis factor production GO:0032720 5 5 0,000 0,03793942 0,10420618 ! intracellular cholesterol transport GO:0032367 5 5 0,000 0,03793942 0,10405112 GO:0032366|intracellular sterol transport, ! regulation of mast cell activation GO:0033003 5 5 0,000 0,03793942 0,10389651 ! morphogenesis of a polarized epithelium GO:0001738 5 5 0,000 0,03793942 0,10374236 ! regulation of hormone metabolic process GO:0032350 5 5 0,000 0,03793942 0,10358867 ! regulation of transcription from RNA polymerase III promoter GO:0006359 5 5 0,000 0,03793942 0,10343543 ! regulation of inflammatory response to antigenic stimulus GO:0002861 5 5 0,000 0,03793942 0,10328264 ! sterol catabolic process GO:0016127 5 5 0,000 0,03793942 0,10313031 GO:0006707|cholesterol catabolic process, ! negative regulation of oxidoreductase activity GO:0051354 5 5 0,000 0,03793942 0,10297842 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 5 5 0,000 0,03793942 0,10282698 ! detection of biotic stimulus GO:0009595 5 5 0,000 0,03793942 0,10267599 ! regulation of immune response to tumor cell GO:0002837 5 5 0,000 0,03793942 0,10252544 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of DNA replication initiation GO:0030174 5 5 0,000 0,03793942 0,10237533 ! zymogen activation GO:0031638 5 5 0,000 0,03793942 0,10222566 ! positive regulation of interleukin-1 beta secretion GO:0050718 5 5 0,000 0,03793942 0,10207642 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 5 5 0,000 0,03793942 0,10192762 GO:0002820|negative regulation of adaptive immune response, ! cellular response to nutrient GO:0031670 5 5 0,000 0,03793942 0,10177926 ! peptidyl-lysine modification GO:0018205 5 5 0,000 0,03793942 0,10163132 ! negative regulation of neuroblast proliferation GO:0007406 5 5 0,000 0,03793942 0,10148382 ! nucleosome positioning GO:0016584 5 5 0,000 0,03793942 0,10133674 ! regulation of isotype switching GO:0045191 5 5 0,000 0,03793942 0,10119009 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 5 5 0,000 0,03793942 0,10104386 ! negative regulation of neurological system process GO:0031645 5 5 0,000 0,03793942 0,10089805 ! regulation of myoblast differentiation GO:0045661 5 5 0,000 0,03793942 0,10075266 ! glutathione biosynthetic process GO:0006750 5 5 0,000 0,03793942 0,1006077 ! NADPH regeneration GO:0006740 5 5 0,000 0,03793942 0,10046315 GO:0006098|pentose-phosphate shunt, ! positive regulation of erythrocyte differentiation GO:0045648 5 5 0,000 0,03793942 0,10031901 ! positive regulation of epidermis development GO:0045684 5 5 0,000 0,03793942 0,10017529 ! musculoskeletal movement GO:0050881 5 5 0,000 0,03793942 0,10003197 GO:0050879|multicellular organismal movement, ! neuromuscular process controlling posture GO:0050884 5 5 0,000 0,03793942 0,09988907 ! sarcomere organization GO:0045214 5 5 0,000 0,03793942 0,09974658 ! regulation of epidermal cell differentiation GO:0045604 5 5 0,000 0,03793942 0,09960449 ! activation of NF-kappaB-inducing kinase activity GO:0007250 5 5 0,000 0,03793942 0,0994628 ! negative regulation of glucose transport GO:0010829 5 5 0,000 0,03793942 0,09932152 GO:0046325|negative regulation of glucose import, ! dopamine biosynthetic process GO:0042416 5 5 0,000 0,03793942 0,09918064 ! male genitalia development GO:0030539 5 5 0,000 0,03793942 0,09904015 ! nicotinamide nucleotide biosynthetic process GO:0019359 5 5 0,000 0,03793942 0,09890007 ! quaternary ammonium group transport GO:0015697 5 5 0,000 0,03793942 0,09876038 ! thyroid hormone metabolic process GO:0042403 5 5 0,000 0,03793942 0,09862109 ! leukocyte mediated cytotoxicity GO:0001909 5 5 0,000 0,03793942 0,09848218 ! removal of superoxide radicals GO:0019430 6 5 0,000 0,03793942 0,09834367 ! regulation of fatty acid oxidation GO:0046320 5 5 0,000 0,03793942 0,09820555 ! regulation of Rac protein signal transduction GO:0035020 5 5 0,000 0,03793942 0,09806781 ! ATP catabolic process GO:0006200 5 5 0,000 0,03793942 0,09793046 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03793942 0,0977935 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 5 5 0,000 0,03793942 0,09765691 ! blastocyst formation GO:0001825 5 5 0,000 0,03793942 0,09752071 ! regulation of fibrinolysis GO:0051917 5 5 0,000 0,03793942 0,09738489 ! embryonic gut development GO:0048566 5 5 0,000 0,03793942 0,09724944 ! negative regulation of organic acid transport GO:0032891 5 5 0,000 0,03793942 0,09711437 ! pyrimidine base metabolic process GO:0006206 5 5 0,000 0,03793942 0,09697968 ! activation of innate immune response GO:0002218 5 5 0,000 0,03793942 0,09684536 GO:0002758|innate immune response-activating signal transduction, ! positive regulation of blood vessel endothelial cell migration GO:0043536 5 5 0,000 0,03793942 0,09671141 ! catecholamine transport GO:0051937 5 5 0,000 0,03793942 0,09657783 ! negative regulation of blood vessel endothelial cell migration GO:0043537 5 5 0,000 0,03793942 0,09644462 ! regulation of NF-kappaB import into nucleus GO:0042345 5 5 0,000 0,03793942 0,09631178 ! muscle adaptation GO:0043500 5 5 0,000 0,03793942 0,0961793 ! positive regulation of actin filament bundle formation GO:0032233 5 5 0,000 0,03793942 0,09604718 ! embryonic heart tube development GO:0035050 5 5 0,000 0,03793942 0,09591543 ! positive regulation of homeostatic process GO:0032846 5 5 0,000 0,03793942 0,09578404 ! defense response to fungus GO:0050832 5 5 0,000 0,03793942 0,09565301 ! lysogeny GO:0030069 5 5 0,000 0,03793942 0,09552234 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 5 5 0,000 0,03793942 0,09539202 ! B cell receptor signaling pathway GO:0050853 5 5 0,000 0,03793942 0,09526206 ! positive regulation of smooth muscle contraction GO:0045987 5 5 0,000 0,03793942 0,09513245 ! establishment of cell polarity GO:0030010 5 5 0,000 0,03793942 0,09500319 ! nucleus localization GO:0051647 5 5 0,000 0,03793942 0,09487429 ! regulation of synapse structure and activity GO:0050803 5 5 0,000 0,03793942 0,09474573 ! blood circulation GO:0008015 99 98 2,000 0,03932423 0,09807112 GO:0003013|circulatory system process, ! regulation of nucleotide biosynthetic process GO:0030808 41 41 1,000 0,03943496 0,09821436 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! amine catabolic process GO:0009310 42 41 1,000 0,03943496 0,09808182 ! phospholipid biosynthetic process GO:0008654 42 41 1,000 0,03943496 0,09794963 ! leukocyte mediated immunity GO:0002443 41 41 1,000 0,03943496 0,0978178 ! monosaccharide catabolic process GO:0046365 41 41 1,000 0,03943496 0,09768633 ! anti-apoptosis GO:0006916 100 99 2,000 0,04033786 0,09978882 ! ectoderm development GO:0007398 99 99 2,000 0,04033786 0,09965505 ! regulation of cyclic nucleotide metabolic process GO:0030799 42 42 1,000 0,04120625 0,10166414 ! development of primary sexual characteristics GO:0045137 42 42 1,000 0,04120625 0,10152822 ! protein ubiquitination GO:0016567 43 42 1,000 0,04120625 0,10139267 ! response to protein stimulus GO:0051789 42 42 1,000 0,04120625 0,10125748 ! one-carbon metabolic process GO:0006730 42 42 1,000 0,04120625 0,10112265 ! muscle organ development GO:0007517 102 100 2,000 0,04136475 0,10137664 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 43 43 1,000 0,0430072 0,10526199 ! alcohol catabolic process GO:0046164 43 43 1,000 0,0430072 0,10512238 ! regulation of nucleotide metabolic process GO:0006140 43 43 1,000 0,0430072 0,10498315 ! negative regulation of organelle organization GO:0010639 45 44 1,000 0,04483729 0,10930571 ! positive regulation of lymphocyte activation GO:0051251 44 44 1,000 0,04483729 0,10916132 ! axon extension GO:0048675 7 6 0,000 0,04535603 0,11027858 ! oligosaccharide biosynthetic process GO:0009312 6 6 0,000 0,04535603 0,11013329 ! N-terminal protein amino acid modification GO:0031365 6 6 0,000 0,04535603 0,10998838 GO:0018409|peptide or protein amino-terminal blocking, ! tRNA modification GO:0006400 6 6 0,000 0,04535603 0,10984385 ! somatic diversification of immune receptors via somatic mutation GO:0002566 6 6 0,000 0,04535603 0,10969969 GO:0016446|somatic hypermutation of immunoglobulin genes, ! 'de novo' posttranslational protein folding GO:0051084 6 6 0,000 0,04535603 0,10955592 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 6 6 0,000 0,04535603 0,10941252 ! negative regulation of cellular catabolic process GO:0031330 6 6 0,000 0,04535603 0,1092695 ! virus-host interaction GO:0019048 6 6 0,000 0,04535603 0,10912685 ! regulation of S phase GO:0033261 6 6 0,000 0,04535603 0,10898457 ! myotube differentiation GO:0014902 6 6 0,000 0,04535603 0,10884266 ! regulation of B cell proliferation GO:0030888 6 6 0,000 0,04535603 0,10870113 ! bone remodeling GO:0046849 6 6 0,000 0,04535603 0,10855996 ! N-glycan processing GO:0006491 6 6 0,000 0,04535603 0,10841915 ! regulation of lipid kinase activity GO:0043550 6 6 0,000 0,04535603 0,10827871 ! glycosaminoglycan catabolic process GO:0006027 6 6 0,000 0,04535603 0,10813864 ! negative regulation of JAK-STAT cascade GO:0046426 6 6 0,000 0,04535603 0,10799892 ! retina development in camera-type eye GO:0060041 6 6 0,000 0,04535603 0,10785957 ! RNA methylation GO:0001510 6 6 0,000 0,04535603 0,10772057 ! cartilage condensation GO:0001502 7 6 0,000 0,04535603 0,10758194 ! regulation of activated T cell proliferation GO:0046006 6 6 0,000 0,04535603 0,10744366 ! regulation of positive chemotaxis GO:0050926 6 6 0,000 0,04535603 0,10730573 GO:0050927|positive regulation of positive chemotaxis, ! artery development GO:0060840 6 6 0,000 0,04535603 0,10716816 GO:0048844|artery morphogenesis, ! positive regulation of neurotransmitter transport GO:0051590 6 6 0,000 0,04535603 0,10703094 ! bile acid metabolic process GO:0008206 6 6 0,000 0,04535603 0,10689407 ! androgen metabolic process GO:0008209 6 6 0,000 0,04535603 0,10675756 ! estrogen metabolic process GO:0008210 6 6 0,000 0,04535603 0,10662139 ! limbic system development GO:0021761 7 6 0,000 0,04535603 0,10648556 ! cytoplasmic sequestering of transcription factor GO:0042994 6 6 0,000 0,04535603 0,10635008 ! positive regulation of heart contraction GO:0045823 6 6 0,000 0,04535603 0,10621495 ! positive regulation of gene expression, epigenetic GO:0045815 6 6 0,000 0,04535603 0,10608016 ! pathogenesis GO:0009405 6 6 0,000 0,04535603 0,10594571 ! negative regulation of protein amino acid phosphorylation GO:0001933 6 6 0,000 0,04535603 0,1058116 ! positive regulation of cell growth GO:0030307 6 6 0,000 0,04535603 0,10567783 ! ribonucleoside triphosphate catabolic process GO:0009203 6 6 0,000 0,04535603 0,1055444 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! nerve growth factor receptor signaling pathway GO:0048011 6 6 0,000 0,04535603 0,10541131 ! inositol phosphate-mediated signaling GO:0048016 6 6 0,000 0,04535603 0,10527855 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 6 6 0,000 0,04535603 0,10514612 ! arginine metabolic process GO:0006525 6 6 0,000 0,04535603 0,10501403 GO:0006527|arginine catabolic process, ! regulation of catecholamine secretion GO:0050433 6 6 0,000 0,04535603 0,10488227 ! oligodendrocyte differentiation GO:0048709 6 6 0,000 0,04535603 0,10475083 ! glutamate catabolic process GO:0006538 7 6 0,000 0,04535603 0,10461973 ! telomere maintenance via telomerase GO:0007004 6 6 0,000 0,04535603 0,10448896 GO:0010833|telomere maintenance via telomere lengthening, ! glucan biosynthetic process GO:0009250 6 6 0,000 0,04535603 0,10435851 GO:0005978|glycogen biosynthetic process, ! L-serine metabolic process GO:0006563 6 6 0,000 0,04535603 0,10422839 ! ER overload response GO:0006983 6 6 0,000 0,04535603 0,10409859 ! V(D)J recombination GO:0033151 6 6 0,000 0,04535603 0,10396911 ! vascular smooth muscle contraction GO:0014829 6 6 0,000 0,04535603 0,10383996 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 6 6 0,000 0,04535603 0,10371112 ! negative regulation of endothelial cell migration GO:0010596 6 6 0,000 0,04535603 0,10358261 ! regulation of heart rate GO:0002027 6 6 0,000 0,04535603 0,10345441 ! lipid digestion GO:0044241 6 6 0,000 0,04535603 0,10332653 ! asymmetric protein localization GO:0008105 6 6 0,000 0,04535603 0,10319897 ! retrograde transport, endosome to Golgi GO:0042147 6 6 0,000 0,04535603 0,10307172 ! phagocytosis, engulfment GO:0006911 6 6 0,000 0,04535603 0,10294479 ! Rac protein signal transduction GO:0016601 6 6 0,000 0,04535603 0,10281816 ! regulation of vascular permeability GO:0043114 6 6 0,000 0,04535603 0,10269185 ! regulation of calcium ion transport into cytosol GO:0010522 6 6 0,000 0,04535603 0,10256585 ! ruffle organization GO:0031529 6 6 0,000 0,04535603 0,10244015 ! preassembly of GPI anchor in ER membrane GO:0016254 6 6 0,000 0,04535603 0,10231477 ! retinoic acid metabolic process GO:0042573 6 6 0,000 0,04535603 0,10218969 ! neutral amino acid transport GO:0015804 6 6 0,000 0,04535603 0,10206492 ! L-amino acid transport GO:0015807 6 6 0,000 0,04535603 0,10194045 ! bone mineralization GO:0030282 6 6 0,000 0,04535603 0,10181628 GO:0031214|biomineral formation, ! rRNA modification GO:0000154 6 6 0,000 0,04535603 0,10169242 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 6 6 0,000 0,04535603 0,10156885 GO:0002717|positive regulation of natural killer cell mediated immunity, GO:0002715|regulation of natural killer cell mediated immunity, GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of bone resorption GO:0045124 6 6 0,000 0,04535603 0,10144559 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 7 6 0,000 0,04535603 0,10132263 ! purine base biosynthetic process GO:0009113 6 6 0,000 0,04535603 0,10119996 ! G1 DNA damage checkpoint GO:0031571 6 6 0,000 0,04535603 0,10107759 ! negative regulation of axonogenesis GO:0050771 7 6 0,000 0,04535603 0,10095551 ! regulation of phagocytosis GO:0050764 6 6 0,000 0,04535603 0,10083373 ! regulation of organ growth GO:0046620 6 6 0,000 0,04535603 0,10071225 ! regulation of circadian rhythm GO:0042752 6 6 0,000 0,04535603 0,10059105 ! positive regulation of T cell mediated immunity GO:0002711 6 6 0,000 0,04535603 0,10047015 ! response to dsRNA GO:0043331 6 6 0,000 0,04535603 0,10034954 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 6 6 0,000 0,04535603 0,10022922 GO:0009147|pyrimidine nucleoside triphosphate metabolic process, ! genitalia development GO:0048806 6 6 0,000 0,04535603 0,10010918 ! sphingomyelin metabolic process GO:0006684 6 6 0,000 0,04535603 0,09998943 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 6 6 0,000 0,04535603 0,09986997 ! positive regulation of B cell differentiation GO:0045579 6 6 0,000 0,04535603 0,09975079 ! multicellular organismal aging GO:0010259 6 6 0,000 0,04535603 0,0996319 ! regulation of focal adhesion formation GO:0051893 7 6 0,000 0,04535603 0,09951329 ! respiratory chain complex IV assembly GO:0008535 6 6 0,000 0,04535603 0,09939497 ! erythrocyte development GO:0048821 6 6 0,000 0,04535603 0,09927692 ! renal water homeostasis GO:0003091 6 6 0,000 0,04535603 0,09915915 ! ribosomal large subunit biogenesis GO:0042273 6 6 0,000 0,04535603 0,09904167 ! regulation of Rho GTPase activity GO:0032319 6 6 0,000 0,04535603 0,09892446 ! ribosome assembly GO:0042255 6 6 0,000 0,04535603 0,09880752 ! positive regulation of Ras GTPase activity GO:0032320 6 6 0,000 0,04535603 0,09869087 ! diencephalon development GO:0021536 6 6 0,000 0,04535603 0,09857449 ! fucose catabolic process GO:0019317 6 6 0,000 0,04535603 0,09845838 GO:0042355|L-fucose catabolic process, ! nitric oxide metabolic process GO:0046209 6 6 0,000 0,04535603 0,09834255 GO:0006809|nitric oxide biosynthetic process, ! regulation of lipid transport GO:0032368 6 6 0,000 0,04535603 0,09822699 ! regulation of cell division GO:0051302 6 6 0,000 0,04535603 0,0981117 ! positive regulation of interleukin-1 secretion GO:0050716 6 6 0,000 0,04535603 0,09799668 ! cellular metabolic compound salvage GO:0043094 6 6 0,000 0,04535603 0,09788193 ! neuroblast proliferation GO:0007405 6 6 0,000 0,04535603 0,09776745 ! regulation of interleukin-1 beta secretion GO:0050706 6 6 0,000 0,04535603 0,09765323 ! nitric oxide mediated signal transduction GO:0007263 6 6 0,000 0,04535603 0,09753928 ! regulation of glucose transport GO:0010827 6 6 0,000 0,04535603 0,0974256 GO:0046324|regulation of glucose import, ! intestinal absorption GO:0050892 6 6 0,000 0,04535603 0,09731218 ! methionine biosynthetic process GO:0009086 6 6 0,000 0,04535603 0,09719903 ! glutamine family amino acid biosynthetic process GO:0009084 6 6 0,000 0,04535603 0,09708614 ! serine family amino acid biosynthetic process GO:0009070 6 6 0,000 0,04535603 0,09697351 ! lymph node development GO:0048535 6 6 0,000 0,04535603 0,09686114 ! organic cation transport GO:0015695 6 6 0,000 0,04535603 0,09674903 ! negative regulation of BMP signaling pathway GO:0030514 6 6 0,000 0,04535603 0,09663719 ! regulation of RNA splicing GO:0043484 6 6 0,000 0,04535603 0,0965256 ! regulation of cellular carbohydrate catabolic process GO:0043471 6 6 0,000 0,04535603 0,09641426 GO:0043470|regulation of carbohydrate catabolic process, GO:0006110|regulation of glycolysis, ! positive regulation of JNK cascade GO:0046330 7 6 0,000 0,04535603 0,09630319 ! sperm-egg recognition GO:0035036 7 6 0,000 0,04535603 0,09619237 GO:0007339|binding of sperm to zona pellucida, ! germ cell migration GO:0008354 6 6 0,000 0,04535603 0,0960818 ! establishment or maintenance of apical/basal cell polarity GO:0035088 6 6 0,000 0,04535603 0,09597149 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 6 6 0,000 0,04535603 0,09586143 ! alditol metabolic process GO:0019400 6 6 0,000 0,04535603 0,09575162 ! regulation of synaptic transmission, GABAergic GO:0032228 6 6 0,000 0,04535603 0,09564207 ! regulation of amino acid transport GO:0051955 6 6 0,000 0,04535603 0,09553276 ! maternal placenta development GO:0001893 6 6 0,000 0,04535603 0,09542371 ! regulation of embryonic development GO:0045995 6 6 0,000 0,04535603 0,0953149 ! negative regulation of immune effector process GO:0002698 6 6 0,000 0,04535603 0,09520634 ! localization within membrane GO:0051668 6 6 0,000 0,04535603 0,09509803 ! amine biosynthetic process GO:0009309 46 45 1,000 0,04669596 0,0977962 ! regulation of actin cytoskeleton organization GO:0032956 46 45 1,000 0,04669596 0,09768519 ! protein processing GO:0016485 45 45 1,000 0,04669596 0,09757444 ! regulation of actin filament-based process GO:0032970 47 46 1,000 0,04858269 0,10140192 ! cyclic-nucleotide-mediated signaling GO:0019935 46 46 1,000 0,04858269 0,10128722 ! tube morphogenesis GO:0035239 47 46 1,000 0,04858269 0,10117277 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 47 47 1,000 0,05049696 0,10504051 ! rhythmic process GO:0048511 47 47 1,000 0,05049696 0,10492209 ! DNA recombination GO:0006310 48 48 1,000 0,05243824 0,10883296 ! respiratory burst GO:0045730 7 7 0,000 0,05271654 0,10928749 ! negative regulation of cell projection organization GO:0031345 8 7 0,000 0,05271654 0,1091647 ! positive regulation of blood pressure GO:0045777 7 7 0,000 0,05271654 0,10904218 ! positive regulation of cellular catabolic process GO:0031331 7 7 0,000 0,05271654 0,10891993 ! pteridine and derivative biosynthetic process GO:0042559 7 7 0,000 0,05271654 0,10879796 ! positive regulation of GTPase activity GO:0043547 7 7 0,000 0,05271654 0,10867627 ! SMAD protein nuclear translocation GO:0007184 7 7 0,000 0,05271654 0,10855484 ! cellular protein complex disassembly GO:0043624 8 7 0,000 0,05271654 0,10843369 GO:0043241|protein complex disassembly, ! gene silencing by RNA GO:0031047 7 7 0,000 0,05271654 0,1083128 ! regulation of receptor-mediated endocytosis GO:0048259 7 7 0,000 0,05271654 0,10819218 ! regulation of neurotransmitter transport GO:0051588 7 7 0,000 0,05271654 0,10807184 ! keratinocyte proliferation GO:0043616 7 7 0,000 0,05271654 0,10795176 ! axis specification GO:0009798 7 7 0,000 0,05271654 0,10783194 ! negative regulation of muscle cell differentiation GO:0051148 7 7 0,000 0,05271654 0,1077124 ! visual behavior GO:0007632 7 7 0,000 0,05271654 0,10759311 GO:0008542|visual learning, ! startle response GO:0001964 7 7 0,000 0,05271654 0,1074741 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 8 7 0,000 0,05271654 0,10735534 ! positive regulation of lipid metabolic process GO:0045834 7 7 0,000 0,05271654 0,10723685 ! negative regulation of lipid metabolic process GO:0045833 7 7 0,000 0,05271654 0,10711861 ! regulation of interferon-gamma biosynthetic process GO:0045072 7 7 0,000 0,05271654 0,10700064 ! endothelial cell differentiation GO:0045446 7 7 0,000 0,05271654 0,10688293 ! negative regulation of striated muscle development GO:0045843 7 7 0,000 0,05271654 0,10676547 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 7 7 0,000 0,05271654 0,10664828 ! hemoglobin metabolic process GO:0020027 7 7 0,000 0,05271654 0,10653134 ! regulation of exit from mitosis GO:0007096 7 7 0,000 0,05271654 0,10641466 ! protein targeting to ER GO:0045047 8 7 0,000 0,05271654 0,10629823 ! cell differentiation in spinal cord GO:0021515 7 7 0,000 0,05271654 0,10618206 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 7 7 0,000 0,05271654 0,10606614 ! endoderm development GO:0007492 7 7 0,000 0,05271654 0,10595047 ! regulation of defense response to virus GO:0050688 7 7 0,000 0,05271654 0,10583506 ! glycolipid biosynthetic process GO:0009247 7 7 0,000 0,05271654 0,10571989 GO:0006688|glycosphingolipid biosynthetic process, ! response to hexose stimulus GO:0009746 7 7 0,000 0,05271654 0,10560498 GO:0034284|response to monosaccharide stimulus, GO:0009749|response to glucose stimulus, ! positive regulation of survival gene product expression GO:0045885 7 7 0,000 0,05271654 0,10549032 ! cardiac muscle tissue development GO:0048738 7 7 0,000 0,05271654 0,1053759 ! nucleotide-sugar metabolic process GO:0009225 7 7 0,000 0,05271654 0,10526174 ! complement activation, alternative pathway GO:0006957 7 7 0,000 0,05271654 0,10514782 ! arachidonic acid secretion GO:0050482 7 7 0,000 0,05271654 0,10503414 GO:0032309|icosanoid secretion, ! polyamine biosynthetic process GO:0006596 7 7 0,000 0,05271654 0,10492071 ! response to X-ray GO:0010165 7 7 0,000 0,05271654 0,10480753 ! regulation of intracellular pH GO:0051453 7 7 0,000 0,05271654 0,10469459 ! UV protection GO:0009650 7 7 0,000 0,05271654 0,1045819 ! DNA integration GO:0015074 7 7 0,000 0,05271654 0,10446944 ! myofibril assembly GO:0030239 7 7 0,000 0,05271654 0,10435723 GO:0055002|striated muscle cell development, ! positive regulation of carbohydrate metabolic process GO:0045913 7 7 0,000 0,05271654 0,10424526 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! positive regulation of muscle contraction GO:0045933 7 7 0,000 0,05271654 0,10413353 ! negative regulation of muscle contraction GO:0045932 7 7 0,000 0,05271654 0,10402204 ! chondroitin sulfate biosynthetic process GO:0030206 7 7 0,000 0,05271654 0,10391078 GO:0030204|chondroitin sulfate metabolic process, ! regulation of exocytosis GO:0017157 8 7 0,000 0,05271654 0,10379977 ! phosphatidylcholine biosynthetic process GO:0006656 7 7 0,000 0,05271654 0,10368899 ! heparan sulfate proteoglycan metabolic process GO:0030201 7 7 0,000 0,05271654 0,10357845 GO:0015012|heparan sulfate proteoglycan biosynthetic process, ! stem cell development GO:0048864 7 7 0,000 0,05271654 0,10346814 GO:0019827|stem cell maintenance, ! negative regulation of myeloid leukocyte differentiation GO:0002762 7 7 0,000 0,05271654 0,10335807 ! NLS-bearing substrate import into nucleus GO:0006607 7 7 0,000 0,05271654 0,10324823 ! axon cargo transport GO:0008088 7 7 0,000 0,05271654 0,10313862 ! eating behavior GO:0042755 7 7 0,000 0,05271654 0,10302925 ! RNA-dependent DNA replication GO:0006278 7 7 0,000 0,05271654 0,10292011 ! purine nucleoside triphosphate catabolic process GO:0009146 7 7 0,000 0,05271654 0,1028112 ! regulation of interleukin-8 production GO:0032677 7 7 0,000 0,05271654 0,10270252 ! purine ribonucleotide catabolic process GO:0009154 7 7 0,000 0,05271654 0,10259407 ! ribosomal small subunit biogenesis GO:0042274 7 7 0,000 0,05271654 0,10248585 ! cranial nerve development GO:0021545 7 7 0,000 0,05271654 0,10237785 ! protein import into peroxisome matrix GO:0016558 7 7 0,000 0,05271654 0,10227009 ! induction of an organ GO:0001759 7 7 0,000 0,05271654 0,10216255 ! leukocyte activation during immune response GO:0002366 7 7 0,000 0,05271654 0,10205523 GO:0002263|cell activation during immune response, ! autonomic nervous system development GO:0048483 7 7 0,000 0,05271654 0,10194814 ! intracellular lipid transport GO:0032365 7 7 0,000 0,05271654 0,10184128 ! detection of chemical stimulus GO:0009593 8 7 0,000 0,05271654 0,10173464 ! negative regulation of cytokine secretion GO:0050710 7 7 0,000 0,05271654 0,10162822 ! regulation of interleukin-1 secretion GO:0050704 7 7 0,000 0,05271654 0,10152203 ! natural killer cell activation GO:0030101 7 7 0,000 0,05271654 0,10141606 ! NADP metabolic process GO:0006739 7 7 0,000 0,05271654 0,1013103 ! neuromuscular synaptic transmission GO:0007274 7 7 0,000 0,05271654 0,10120477 ! synaptic transmission, cholinergic GO:0007271 7 7 0,000 0,05271654 0,10109946 ! ubiquinone metabolic process GO:0006743 7 7 0,000 0,05271654 0,10099437 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, GO:0042375|quinone cofactor metabolic process, ! regulation of macrophage differentiation GO:0045649 8 7 0,000 0,05271654 0,10088949 ! regulation of osteoclast differentiation GO:0045670 7 7 0,000 0,05271654 0,10078484 ! negative regulation of cell-substrate adhesion GO:0010812 8 7 0,000 0,05271654 0,1006804 GO:0001953|negative regulation of cell-matrix adhesion, ! multicellular organismal water homeostasis GO:0050891 7 7 0,000 0,05271654 0,10057617 ! regulation of ATPase activity GO:0043462 7 7 0,000 0,05271654 0,10047216 ! cell-cell recognition GO:0009988 8 7 0,000 0,05271654 0,10036837 ! hormone catabolic process GO:0042447 7 7 0,000 0,05271654 0,10026479 ! dopamine metabolic process GO:0042417 7 7 0,000 0,05271654 0,10016142 ! cAMP biosynthetic process GO:0006171 7 7 0,000 0,05271654 0,10005827 ! oxygen transport GO:0015671 7 7 0,000 0,05271654 0,09995533 ! pyridine nucleotide biosynthetic process GO:0019363 7 7 0,000 0,05271654 0,0998526 ! regulation of mRNA stability GO:0043488 7 7 0,000 0,05271654 0,09975008 ! biogenic amine catabolic process GO:0042402 7 7 0,000 0,05271654 0,09964778 ! regulation of axon extension GO:0030516 7 7 0,000 0,05271654 0,09954568 ! cell killing GO:0001906 7 7 0,000 0,05271654 0,09944379 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 7 0,000 0,05271654 0,09934211 ! adult feeding behavior GO:0008343 7 7 0,000 0,05271654 0,09924064 ! pyrimidine nucleotide catabolic process GO:0006244 7 7 0,000 0,05271654 0,09913937 ! positive regulation of protein polymerization GO:0032273 7 7 0,000 0,05271654 0,09903831 ! T cell receptor signaling pathway GO:0050852 7 7 0,000 0,05271654 0,09893746 ! response to cold GO:0009409 7 7 0,000 0,05271654 0,09883681 ! leukocyte differentiation GO:0002521 50 49 1,000 0,05440602 0,10190071 ! ossification GO:0001503 50 49 1,000 0,05440602 0,10179726 GO:0060348|bone development, ! cell cycle arrest GO:0007050 49 49 1,000 0,05440602 0,10169402 ! skeletal muscle tissue development GO:0007519 50 49 1,000 0,05440602 0,10159099 GO:0060538|skeletal muscle organ development, ! positive regulation of cell activation GO:0050867 49 49 1,000 0,05440602 0,10148816 GO:0002696|positive regulation of leukocyte activation, ! T cell activation GO:0042110 51 50 1,000 0,05639981 0,10510096 ! nitrogen compound catabolic process GO:0044270 51 50 1,000 0,05639981 0,10499479 ! regulation of neurogenesis GO:0050767 51 50 1,000 0,05639981 0,10488885 ! interphase of mitotic cell cycle GO:0051329 52 51 1,000 0,05841909 0,10853466 GO:0051325|interphase, ! protein maturation GO:0051604 51 51 1,000 0,05841909 0,10842536 ! negative regulation of muscle development GO:0048635 8 8 0,000 0,06002136 0,11128709 ! very-long-chain fatty acid metabolic process GO:0000038 8 8 0,000 0,06002136 0,11117524 ! positive regulation of cell killing GO:0031343 8 8 0,000 0,06002136 0,11106362 ! superoxide anion generation GO:0042554 8 8 0,000 0,06002136 0,11095222 ! sulfur amino acid biosynthetic process GO:0000097 8 8 0,000 0,06002136 0,11084105 ! cGMP metabolic process GO:0046068 8 8 0,000 0,06002136 0,11073009 GO:0006182|cGMP biosynthetic process, ! thyroid gland development GO:0030878 8 8 0,000 0,06002136 0,11061936 ! 'de novo' protein folding GO:0006458 8 8 0,000 0,06002136 0,11050886 ! dicarboxylic acid transport GO:0006835 8 8 0,000 0,06002136 0,11039857 ! phosphoinositide phosphorylation GO:0046854 8 8 0,000 0,06002136 0,1102885 ! embryonic hindlimb morphogenesis GO:0035116 8 8 0,000 0,06002136 0,11017865 ! zinc ion transport GO:0006829 8 8 0,000 0,06002136 0,11006902 ! embryonic forelimb morphogenesis GO:0035115 8 8 0,000 0,06002136 0,10995961 ! folic acid and derivative biosynthetic process GO:0009396 8 8 0,000 0,06002136 0,10985041 ! regulation of neuronal synaptic plasticity GO:0048168 8 8 0,000 0,06002136 0,10974143 ! cardiac muscle contraction GO:0060048 8 8 0,000 0,06002136 0,10963267 ! lipid localization GO:0010876 8 8 0,000 0,06002136 0,10952412 GO:0019915|lipid storage, ! response to pain GO:0048265 8 8 0,000 0,06002136 0,10941579 ! response to cAMP GO:0051591 8 8 0,000 0,06002136 0,10930767 ! COPI coating of Golgi vesicle GO:0048205 8 8 0,000 0,06002136 0,10919977 GO:0048200|Golgi transport vesicle coating, ! regulation of excitatory postsynaptic membrane potential GO:0060079 8 8 0,000 0,06002136 0,10909207 ! negative regulation of transcription factor import into nucleus GO:0042992 8 8 0,000 0,06002136 0,1089846 ! negative regulation of ion transport GO:0043271 8 8 0,000 0,06002136 0,10887733 ! regulation of response to extracellular stimulus GO:0032104 8 8 0,000 0,06002136 0,10877027 GO:0032107|regulation of response to nutrient levels, ! adult walking behavior GO:0007628 8 8 0,000 0,06002136 0,10866342 ! sensory perception of taste GO:0050909 8 8 0,000 0,06002136 0,10855679 ! organelle fusion GO:0048284 8 8 0,000 0,06002136 0,10845036 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 8 0,000 0,06002136 0,10834414 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 8 8 0,000 0,06002136 0,10823813 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 8 8 0,000 0,06002136 0,10813232 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 8 8 0,000 0,06002136 0,10802672 ! sperm motility GO:0030317 8 8 0,000 0,06002136 0,10792133 ! regulation of striated muscle contraction GO:0006942 8 8 0,000 0,06002136 0,10781614 ! glycine metabolic process GO:0006544 8 8 0,000 0,06002136 0,10771116 ! ribonucleotide catabolic process GO:0009261 8 8 0,000 0,06002136 0,10760639 ! negative regulation of microtubule depolymerization GO:0007026 8 8 0,000 0,06002136 0,10750181 GO:0031114|regulation of microtubule depolymerization, ! polyamine metabolic process GO:0006595 8 8 0,000 0,06002136 0,10739744 ! Golgi organization GO:0007030 8 8 0,000 0,06002136 0,10729327 ! cell-cell junction assembly GO:0007043 8 8 0,000 0,06002136 0,10718931 ! regulation of stress fiber formation GO:0051492 9 8 0,000 0,06002136 0,10708554 ! positive regulation of endothelial cell migration GO:0010595 8 8 0,000 0,06002136 0,10698198 ! fructose metabolic process GO:0006000 8 8 0,000 0,06002136 0,10687861 ! mannose metabolic process GO:0006013 9 8 0,000 0,06002136 0,10677545 ! sex determination GO:0007530 8 8 0,000 0,06002136 0,10667248 ! plasma membrane fusion GO:0045026 8 8 0,000 0,06002136 0,10656971 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 8 8 0,000 0,06002136 0,10646715 ! response to fungus GO:0009620 8 8 0,000 0,06002136 0,10636477 ! stem cell differentiation GO:0048863 8 8 0,000 0,06002136 0,1062626 ! positive regulation of myeloid leukocyte differentiation GO:0002763 9 8 0,000 0,06002136 0,10616062 ! embryonic digit morphogenesis GO:0042733 8 8 0,000 0,06002136 0,10605883 ! regulation of cytokine production during immune response GO:0002718 8 8 0,000 0,06002136 0,10595725 ! base-excision repair, AP site formation GO:0006285 8 8 0,000 0,06002136 0,10585585 ! regulation of vasodilation GO:0042312 8 8 0,000 0,06002136 0,10575465 ! vasoconstriction GO:0042310 8 8 0,000 0,06002136 0,10565364 ! regulation of T cell mediated immunity GO:0002709 8 8 0,000 0,06002136 0,10555283 ! muscle cell development GO:0055001 8 8 0,000 0,06002136 0,10545221 ! nucleoside triphosphate catabolic process GO:0009143 8 8 0,000 0,06002136 0,10535178 ! regulation of fatty acid metabolic process GO:0019217 8 8 0,000 0,06002136 0,10525154 ! sensory perception of pain GO:0019233 8 8 0,000 0,06002136 0,10515149 ! gastrulation with mouth forming second GO:0001702 8 8 0,000 0,06002136 0,10505163 ! immunoglobulin production during immune response GO:0002381 8 8 0,000 0,06002136 0,10495196 GO:0002208|somatic diversification of immunoglobulins during immune response, GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! mRNA cleavage GO:0006379 8 8 0,000 0,06002136 0,10485248 ! chromatin silencing GO:0006342 8 8 0,000 0,06002136 0,10475319 ! tissue regeneration GO:0042246 8 8 0,000 0,06002136 0,10465408 ! negative regulation of blood coagulation GO:0030195 9 8 0,000 0,06002136 0,10455516 ! peptide biosynthetic process GO:0043043 9 8 0,000 0,06002136 0,10445643 ! water homeostasis GO:0030104 8 8 0,000 0,06002136 0,10435789 ! cofactor transport GO:0051181 8 8 0,000 0,06002136 0,10425953 ! acid secretion GO:0046717 8 8 0,000 0,06002136 0,10416136 ! C21-steroid hormone biosynthetic process GO:0006700 8 8 0,000 0,06002136 0,10406337 ! protein-chromophore linkage GO:0018298 9 8 0,000 0,06002136 0,10396557 ! catecholamine biosynthetic process GO:0042423 8 8 0,000 0,06002136 0,10386795 ! regulation of RNA stability GO:0043487 8 8 0,000 0,06002136 0,10377051 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 8 8 0,000 0,06002136 0,10367326 ! regulation of generation of precursor metabolites and energy GO:0043467 8 8 0,000 0,06002136 0,10357618 ! aromatic compound biosynthetic process GO:0019438 8 8 0,000 0,06002136 0,10347929 ! regulation of organic acid transport GO:0032890 8 8 0,000 0,06002136 0,10338258 ! positive regulation of calcium ion transport GO:0051928 8 8 0,000 0,06002136 0,10328605 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 8 8 0,000 0,06002136 0,10318971 ! regulation of multi-organism process GO:0043900 8 8 0,000 0,06002136 0,10309354 ! positive regulation of amine transport GO:0051954 8 8 0,000 0,06002136 0,10299755 ! developmental induction GO:0031128 8 8 0,000 0,06002136 0,10290173 GO:0045168|cell-cell signaling involved in cell fate specification, ! positive regulation of calcium-mediated signaling GO:0050850 8 8 0,000 0,06002136 0,1028061 ! actin filament polymerization GO:0030041 9 8 0,000 0,06002136 0,10271064 ! peptide hormone processing GO:0016486 8 8 0,000 0,06002136 0,10261537 ! positive regulation of synaptic transmission GO:0050806 8 8 0,000 0,06002136 0,10252026 ! regulation of steroid biosynthetic process GO:0050810 8 8 0,000 0,06002136 0,10242534 ! cholesterol metabolic process GO:0008203 52 52 1,000 0,06046338 0,10308418 ! cell fate commitment GO:0045165 52 52 1,000 0,06046338 0,10298891 ! carbohydrate catabolic process GO:0016052 53 53 1,000 0,06253218 0,10641441 ! response to hypoxia GO:0001666 53 53 1,000 0,06253218 0,10631624 ! response to oxygen levels GO:0070482 55 54 1,000 0,06462501 0,10977317 ! sulfur metabolic process GO:0006790 55 54 1,000 0,06462501 0,10967209 ! microtubule cytoskeleton organization GO:0000226 55 55 1,000 0,0667414 0,11315952 ! lactation GO:0007595 10 9 0,000 0,0672709 0,11395246 ! embryonic pattern specification GO:0009880 10 9 0,000 0,0672709 0,11384782 ! positive regulation of cell size GO:0045793 9 9 0,000 0,0672709 0,11374337 ! positive regulation of cell projection organization GO:0031346 9 9 0,000 0,0672709 0,11363911 ! regulation of membrane protein ectodomain proteolysis GO:0051043 9 9 0,000 0,0672709 0,11353505 ! positive regulation of protein complex assembly GO:0031334 9 9 0,000 0,0672709 0,11343117 ! cortical actin cytoskeleton organization GO:0030866 10 9 0,000 0,0672709 0,11332749 ! regulation of nitric-oxide synthase activity GO:0050999 9 9 0,000 0,0672709 0,11322399 ! viral genome replication GO:0019079 9 9 0,000 0,0672709 0,11312069 ! phospholipid catabolic process GO:0009395 9 9 0,000 0,0672709 0,11301757 ! copper ion transport GO:0006825 9 9 0,000 0,0672709 0,11291464 ! lipid phosphorylation GO:0046834 9 9 0,000 0,0672709 0,1128119 ! aminoglycan catabolic process GO:0006026 9 9 0,000 0,0672709 0,11270934 ! Golgi vesicle budding GO:0048194 9 9 0,000 0,0672709 0,11260697 ! regulation of cell-cell adhesion GO:0022407 9 9 0,000 0,0672709 0,11250479 ! RNA polyadenylation GO:0043631 9 9 0,000 0,0672709 0,11240279 GO:0006378|mRNA polyadenylation, ! gamma-aminobutyric acid signaling pathway GO:0007214 9 9 0,000 0,0672709 0,11230097 ! regulation of postsynaptic membrane potential GO:0060078 9 9 0,000 0,0672709 0,11219934 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 9 9 0,000 0,0672709 0,1120979 ! phospholipid efflux GO:0033700 9 9 0,000 0,0672709 0,11199663 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 9 9 0,000 0,0672709 0,11189555 ! cytokine biosynthetic process GO:0042089 9 9 0,000 0,0672709 0,11179466 GO:0042107|cytokine metabolic process, ! positive regulation of endothelial cell proliferation GO:0001938 9 9 0,000 0,0672709 0,11169394 ! negative regulation of gene expression, epigenetic GO:0045814 9 9 0,000 0,0672709 0,11159341 ! regulation of interleukin-2 biosynthetic process GO:0045076 9 9 0,000 0,0672709 0,11149305 ! platelet-derived growth factor receptor signaling pathway GO:0048008 9 9 0,000 0,0672709 0,11139288 ! pyrimidine ribonucleotide metabolic process GO:0009218 9 9 0,000 0,0672709 0,11129289 ! methionine metabolic process GO:0006555 9 9 0,000 0,0672709 0,11119307 ! glutamine metabolic process GO:0006541 9 9 0,000 0,0672709 0,11109344 ! cerebral cortex development GO:0021987 9 9 0,000 0,0672709 0,11099398 ! response to osmotic stress GO:0006970 9 9 0,000 0,0672709 0,1108947 ! pigmentation during development GO:0048066 9 9 0,000 0,0672709 0,1107956 ! reverse cholesterol transport GO:0043691 9 9 0,000 0,0672709 0,11069667 ! central nervous system neuron development GO:0021954 10 9 0,000 0,0672709 0,11059793 ! pyrimidine ribonucleoside metabolic process GO:0046131 9 9 0,000 0,0672709 0,11049935 ! nucleobase biosynthetic process GO:0046112 9 9 0,000 0,0672709 0,11040096 ! substrate-bound cell migration GO:0006929 9 9 0,000 0,0672709 0,11030273 ! neurotransmitter metabolic process GO:0042133 11 9 0,000 0,0672709 0,11020469 ! negative regulation of caspase activity GO:0043154 9 9 0,000 0,0672709 0,11010682 ! L-glutamate transport GO:0015813 9 9 0,000 0,0672709 0,11000912 GO:0015800|acidic amino acid transport, ! regulation of dephosphorylation GO:0035303 9 9 0,000 0,0672709 0,10991159 ! cotranslational protein targeting to membrane GO:0006613 10 9 0,000 0,0672709 0,10981424 ! behavioral interaction between organisms GO:0051705 9 9 0,000 0,0672709 0,10971706 ! negative regulation of protein import into nucleus GO:0042308 9 9 0,000 0,0672709 0,10962005 ! DNA replication initiation GO:0006270 9 9 0,000 0,0672709 0,10952321 ! regulation of cellular pH GO:0030641 9 9 0,000 0,0672709 0,10942654 ! histone acetylation GO:0016573 9 9 0,000 0,0672709 0,10933005 ! DNA fragmentation involved in apoptosis GO:0006309 9 9 0,000 0,0672709 0,10923372 ! regulation of immunoglobulin mediated immune response GO:0002889 9 9 0,000 0,0672709 0,10913757 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 10 9 0,000 0,0672709 0,10904158 ! positive regulation of oxidoreductase activity GO:0051353 9 9 0,000 0,0672709 0,10894576 ! positive regulation of cytokine secretion GO:0050715 9 9 0,000 0,0672709 0,10885011 ! negative regulation of inflammatory response GO:0050728 9 9 0,000 0,0672709 0,10875463 ! negative regulation of protein secretion GO:0050709 9 9 0,000 0,0672709 0,10865931 ! positive regulation of transmission of nerve impulse GO:0051971 9 9 0,000 0,0672709 0,10856416 ! collagen catabolic process GO:0030574 9 9 0,000 0,0672709 0,10846918 ! purine base metabolic process GO:0006144 9 9 0,000 0,0672709 0,10837437 ! gas transport GO:0015669 9 9 0,000 0,0672709 0,10827972 ! cholesterol efflux GO:0033344 9 9 0,000 0,0672709 0,10818523 ! regulation of leukocyte mediated cytotoxicity GO:0001910 9 9 0,000 0,0672709 0,10809091 ! estrogen receptor signaling pathway GO:0030520 9 9 0,000 0,0672709 0,10799675 ! somatic recombination of immunoglobulin gene segments GO:0016447 9 9 0,000 0,0672709 0,10790276 ! regulation of actin filament bundle formation GO:0032231 10 9 0,000 0,0672709 0,10780893 ! regulation of blood vessel endothelial cell migration GO:0043535 9 9 0,000 0,0672709 0,10771527 ! regulation of calcium-mediated signaling GO:0050848 9 9 0,000 0,0672709 0,10762177 ! actin filament-based movement GO:0030048 9 9 0,000 0,0672709 0,10752842 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 9 9 0,000 0,0672709 0,10743525 ! regulation of nervous system development GO:0051960 57 56 1,000 0,06888087 0,10991121 ! protein import into nucleus, docking GO:0000059 10 10 0,000 0,07446558 0,11871978 ! regulation of protein ubiquitination GO:0031396 10 10 0,000 0,07446558 0,11861717 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 10 10 0,000 0,07446558 0,11851474 ! regulation of glucose metabolic process GO:0010906 10 10 0,000 0,07446558 0,11841248 ! ER-associated protein catabolic process GO:0030433 10 10 0,000 0,07446558 0,1183104 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of cell killing GO:0031341 10 10 0,000 0,07446558 0,1182085 ! neuron maturation GO:0042551 10 10 0,000 0,07446558 0,11810677 ! pteridine and derivative metabolic process GO:0042558 10 10 0,000 0,07446558 0,11800522 ! cortical cytoskeleton organization GO:0030865 11 10 0,000 0,07446558 0,11790384 ! regulation of lipid biosynthetic process GO:0046890 10 10 0,000 0,07446558 0,11780263 ! glucosamine metabolic process GO:0006041 10 10 0,000 0,07446558 0,1177016 GO:0006044|N-acetylglucosamine metabolic process, ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 10 10 0,000 0,07446558 0,11760074 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! inositol metabolic process GO:0006020 10 10 0,000 0,07446558 0,11750006 ! cAMP metabolic process GO:0046058 10 10 0,000 0,07446558 0,11739955 ! vesicle targeting, to, from or within Golgi GO:0048199 10 10 0,000 0,07446558 0,1172992 ! transcription from RNA polymerase III promoter GO:0006383 10 10 0,000 0,07446558 0,11719903 ! forelimb morphogenesis GO:0035136 10 10 0,000 0,07446558 0,11709903 ! glial cell development GO:0021782 10 10 0,000 0,07446558 0,11699921 ! phototransduction GO:0007602 11 10 0,000 0,07446558 0,11689955 ! auditory receptor cell differentiation GO:0042491 10 10 0,000 0,07446558 0,11680006 ! myoblast differentiation GO:0045445 10 10 0,000 0,07446558 0,11670074 ! centrosome cycle GO:0007098 10 10 0,000 0,07446558 0,11660159 ! inactivation of MAPK activity GO:0000188 10 10 0,000 0,07446558 0,1165026 ! positive regulation of proteolysis GO:0045862 10 10 0,000 0,07446558 0,11640379 ! response to carbohydrate stimulus GO:0009743 10 10 0,000 0,07446558 0,11630514 ! regulation of survival gene product expression GO:0045884 10 10 0,000 0,07446558 0,11620666 ! induction of apoptosis via death domain receptors GO:0008625 10 10 0,000 0,07446558 0,11610835 ! protein polyubiquitination GO:0000209 10 10 0,000 0,07446558 0,1160102 ! glutamate metabolic process GO:0006536 11 10 0,000 0,07446558 0,11591222 ! plasma membrane organization GO:0007009 10 10 0,000 0,07446558 0,1158144 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 10 10 0,000 0,07446558 0,11571675 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! lysosomal transport GO:0007041 10 10 0,000 0,07446558 0,11561927 ! cellular response to unfolded protein GO:0034620 10 10 0,000 0,07446558 0,11552194 GO:0030968|endoplasmic reticulum unfolded protein response, ! central nervous system neuron differentiation GO:0021953 11 10 0,000 0,07446558 0,11542478 ! purine ribonucleoside metabolic process GO:0046128 10 10 0,000 0,07446558 0,11532779 GO:0042278|purine nucleoside metabolic process, ! vesicle coating GO:0006901 10 10 0,000 0,07446558 0,11523096 ! cell structure disassembly during apoptosis GO:0006921 10 10 0,000 0,07446558 0,11513429 ! embryo implantation GO:0007566 11 10 0,000 0,07446558 0,11503778 ! protein targeting to peroxisome GO:0006625 10 10 0,000 0,07446558 0,11494143 ! protein targeting to mitochondrion GO:0006626 10 10 0,000 0,07446558 0,11484525 GO:0070585|protein localization in mitochondrion, ! intermediate filament cytoskeleton organization GO:0045104 10 10 0,000 0,07446558 0,11474922 ! protein export from nucleus GO:0006611 10 10 0,000 0,07446558 0,11465336 ! negative regulation of immune response GO:0050777 10 10 0,000 0,07446558 0,11455765 ! cytolysis GO:0019835 10 10 0,000 0,07446558 0,11446211 ! positive regulation of biomineral formation GO:0070169 10 10 0,000 0,07446558 0,11436672 GO:0030501|positive regulation of bone mineralization, ! mismatch repair GO:0006298 10 10 0,000 0,07446558 0,1142715 ! regulation of B cell differentiation GO:0045577 10 10 0,000 0,07446558 0,11417643 ! histone deacetylation GO:0016575 10 10 0,000 0,07446558 0,11408152 ! mRNA splice site selection GO:0006376 11 10 0,000 0,07446558 0,11398677 ! synaptic vesicle transport GO:0048489 11 10 0,000 0,07446558 0,11389217 ! positive regulation of neurological system process GO:0031646 10 10 0,000 0,07446558 0,11379773 ! sphingolipid biosynthetic process GO:0030148 10 10 0,000 0,07446558 0,11370345 GO:0046467|membrane lipid biosynthetic process, ! sphingolipid catabolic process GO:0030149 10 10 0,000 0,07446558 0,11360933 GO:0046466|membrane lipid catabolic process, ! nerve-nerve synaptic transmission GO:0007270 10 10 0,000 0,07446558 0,11351536 ! regulation of erythrocyte differentiation GO:0045646 10 10 0,000 0,07446558 0,11342154 ! regulation of epidermis development GO:0045682 10 10 0,000 0,07446558 0,11332788 ! folic acid and derivative metabolic process GO:0006760 10 10 0,000 0,07446558 0,11323438 ! negative regulation of neuron differentiation GO:0045665 10 10 0,000 0,07446558 0,11314103 ! aspartate family amino acid biosynthetic process GO:0009067 10 10 0,000 0,07446558 0,11304783 ! regulation of BMP signaling pathway GO:0030510 10 10 0,000 0,07446558 0,11295479 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 10 10 0,000 0,07446558 0,1128619 ! nerve development GO:0021675 10 10 0,000 0,07446558 0,11276916 ! epithelial to mesenchymal transition GO:0001837 10 10 0,000 0,07446558 0,11267657 ! embryonic organ morphogenesis GO:0048562 10 10 0,000 0,07446558 0,11258414 ! positive regulation of neuron apoptosis GO:0043525 10 10 0,000 0,07446558 0,11249186 ! mRNA 3'-end processing GO:0031124 10 10 0,000 0,07446558 0,11239973 ! antigen receptor-mediated signaling pathway GO:0050851 10 10 0,000 0,07446558 0,11230775 ! negative regulation of coagulation GO:0050819 11 10 0,000 0,07446558 0,11221592 ! regulation of cell development GO:0060284 60 59 1,000 0,07543318 0,11358117 ! sterol metabolic process GO:0016125 59 59 1,000 0,07543318 0,11348845 ! cellular aromatic compound metabolic process GO:0006725 60 59 1,000 0,07543318 0,11339588 ! cellular respiration GO:0045333 62 61 1,000 0,07990842 0,12002544 ! carboxylic acid catabolic process GO:0046395 63 61 1,000 0,07990842 0,1199277 GO:0016054|organic acid catabolic process, ! protein secretion GO:0009306 11 11 0,000 0,0816058 0,12237551 ! oligosaccharide metabolic process GO:0009311 11 11 0,000 0,0816058 0,12227601 ! myeloid leukocyte differentiation GO:0002573 12 11 0,000 0,0816058 0,12217668 ! negative regulation of defense response GO:0031348 11 11 0,000 0,0816058 0,12207751 ! G1 phase of mitotic cell cycle GO:0000080 12 11 0,000 0,0816058 0,12197851 ! determination of bilateral symmetry GO:0009855 11 11 0,000 0,0816058 0,12187966 GO:0009799|determination of symmetry, GO:0007368|determination of left/right symmetry, ! positive regulation of hormone secretion GO:0046887 11 11 0,000 0,0816058 0,12178097 ! cellular component assembly involved in morphogenesis GO:0010927 11 11 0,000 0,0816058 0,12168244 ! microtubule-based transport GO:0010970 11 11 0,000 0,0816058 0,12158407 ! endothelial cell migration GO:0043542 11 11 0,000 0,0816058 0,12148586 ! peroxisomal transport GO:0043574 11 11 0,000 0,0816058 0,12138781 ! protein amino acid methylation GO:0006479 11 11 0,000 0,0816058 0,12128992 GO:0008213|protein amino acid alkylation, ! protein amino acid acetylation GO:0006473 11 11 0,000 0,0816058 0,12119218 ! heart contraction GO:0060047 11 11 0,000 0,0816058 0,1210946 GO:0003015|heart process, ! detection of light stimulus involved in sensory perception GO:0050962 12 11 0,000 0,0816058 0,12099718 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! dendrite development GO:0016358 11 11 0,000 0,0816058 0,12089992 ! T cell proliferation GO:0042098 11 11 0,000 0,0816058 0,12080281 ! regulation of transmembrane transporter activity GO:0022898 11 11 0,000 0,0816058 0,12070586 GO:0032412|regulation of ion transmembrane transporter activity, GO:0032409|regulation of transporter activity, ! negative regulation of endothelial cell proliferation GO:0001937 11 11 0,000 0,0816058 0,12060906 ! spinal cord development GO:0021510 11 11 0,000 0,0816058 0,12051242 ! activation of MAPKK activity GO:0000186 12 11 0,000 0,0816058 0,12041593 ! smooth muscle contraction GO:0006939 11 11 0,000 0,0816058 0,1203196 ! cellular response to starvation GO:0009267 11 11 0,000 0,0816058 0,12022342 ! positive regulation of nitric oxide biosynthetic process GO:0045429 11 11 0,000 0,0816058 0,12012739 ! cellular macromolecular complex disassembly GO:0034623 12 11 0,000 0,0816058 0,12003152 ! digestive system process GO:0022600 11 11 0,000 0,0816058 0,1199358 ! mitotic spindle organization GO:0007052 11 11 0,000 0,0816058 0,11984024 ! fucose metabolic process GO:0006004 11 11 0,000 0,0816058 0,11974482 ! membrane budding GO:0006900 11 11 0,000 0,0816058 0,11964956 ! monoamine transport GO:0015844 11 11 0,000 0,0816058 0,11955445 ! regulation of cellular ketone metabolic process GO:0010565 11 11 0,000 0,0816058 0,11945949 ! response to lipopolysaccharide GO:0032496 11 11 0,000 0,0816058 0,11936468 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 11 11 0,000 0,0816058 0,11927002 ! body fluid secretion GO:0007589 11 11 0,000 0,0816058 0,11917551 ! G1/S transition checkpoint GO:0031575 12 11 0,000 0,0816058 0,11908115 ! intermediate filament-based process GO:0045103 11 11 0,000 0,0816058 0,11898694 ! interaction with host GO:0051701 11 11 0,000 0,0816058 0,11889288 ! membrane depolarization GO:0051899 11 11 0,000 0,0816058 0,11879897 ! regulation of interleukin-2 production GO:0032663 11 11 0,000 0,0816058 0,11870521 ! regulation of ARF GTPase activity GO:0032312 11 11 0,000 0,0816058 0,11861159 ! regulation of monooxygenase activity GO:0032768 11 11 0,000 0,0816058 0,11851812 ! negative regulation of angiogenesis GO:0016525 11 11 0,000 0,0816058 0,1184248 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 11 11 0,000 0,0816058 0,11833163 ! regulation of cellular carbohydrate metabolic process GO:0010675 11 11 0,000 0,0816058 0,1182386 GO:0006109|regulation of carbohydrate metabolic process, ! vitamin transport GO:0051180 11 11 0,000 0,0816058 0,11814572 ! muscle maintenance GO:0046716 12 11 0,000 0,0816058 0,11805298 ! vitamin A metabolic process GO:0006776 11 11 0,000 0,0816058 0,11796039 ! steroid catabolic process GO:0006706 11 11 0,000 0,0816058 0,11786794 ! endocrine process GO:0050886 11 11 0,000 0,0816058 0,11777564 GO:0001990|regulation of systemic arterial blood pressure by hormone, ! proximal/distal pattern formation GO:0009954 11 11 0,000 0,0816058 0,11768349 ! somatic diversification of immunoglobulins GO:0016445 11 11 0,000 0,0816058 0,11759148 ! RNA 3'-end processing GO:0031123 11 11 0,000 0,0816058 0,11749961 ! morphogenesis of an epithelium GO:0002009 63 62 1,000 0,08217682 0,11822941 GO:0060429|epithelium development, ! regulation of secretion GO:0051046 65 63 1,000 0,08446516 0,1214269 ! negative regulation of cellular component organization GO:0051129 65 63 1,000 0,08446516 0,12133225 ! regulation of cytoskeleton organization GO:0051493 66 64 1,000 0,08677301 0,12455035 ! translational initiation GO:0006413 12 12 0,000 0,08869197 0,12720569 ! initiation of viral infection GO:0019059 12 12 0,000 0,08869197 0,12710677 ! DNA catabolic process, endonucleolytic GO:0000737 12 12 0,000 0,08869197 0,12700801 ! iron ion transport GO:0006826 13 12 0,000 0,08869197 0,1269094 ! phosphatidylcholine metabolic process GO:0046470 12 12 0,000 0,08869197 0,12681094 ! amino sugar metabolic process GO:0006040 12 12 0,000 0,08869197 0,12671264 ! post-Golgi vesicle-mediated transport GO:0006892 12 12 0,000 0,08869197 0,12661449 ! protein amino acid ADP-ribosylation GO:0006471 12 12 0,000 0,08869197 0,12651649 ! heterophilic cell adhesion GO:0007157 12 12 0,000 0,08869197 0,12641864 ! collagen metabolic process GO:0032963 12 12 0,000 0,08869197 0,12632095 ! hindlimb morphogenesis GO:0035137 12 12 0,000 0,08869197 0,1262234 ! xenobiotic metabolic process GO:0006805 12 12 0,000 0,08869197 0,12612601 ! glutamate signaling pathway GO:0007215 12 12 0,000 0,08869197 0,12602876 ! C21-steroid hormone metabolic process GO:0008207 13 12 0,000 0,08869197 0,12593167 ! regulation of muscle cell differentiation GO:0051147 13 12 0,000 0,08869197 0,12583472 ! cellular response to hydrogen peroxide GO:0070301 12 12 0,000 0,08869197 0,12573793 GO:0042744|hydrogen peroxide catabolic process, ! negative regulation of peptidase activity GO:0010466 12 12 0,000 0,08869197 0,12564128 ! actomyosin structure organization GO:0031032 12 12 0,000 0,08869197 0,12554478 ! microtubule organizing center organization GO:0031023 12 12 0,000 0,08869197 0,12544843 GO:0051297|centrosome organization, ! positive regulation of endocytosis GO:0045807 12 12 0,000 0,08869197 0,12535223 ! retinoid metabolic process GO:0001523 12 12 0,000 0,08869197 0,12525617 GO:0016101|diterpenoid metabolic process, ! mitotic chromosome condensation GO:0007076 12 12 0,000 0,08869197 0,12516026 ! positive regulation of innate immune response GO:0045089 12 12 0,000 0,08869197 0,1250645 ! deoxyribonucleotide catabolic process GO:0009264 12 12 0,000 0,08869197 0,12496889 ! vacuolar transport GO:0007034 12 12 0,000 0,08869197 0,12487342 ! polysaccharide catabolic process GO:0000272 12 12 0,000 0,08869197 0,1247781 ! vesicle docking during exocytosis GO:0006904 12 12 0,000 0,08869197 0,12468292 ! barbed-end actin filament capping GO:0051016 12 12 0,000 0,08869197 0,12458789 GO:0051693|actin filament capping, ! osteoblast differentiation GO:0001649 12 12 0,000 0,08869197 0,124493 ! regulation of insulin secretion GO:0050796 12 12 0,000 0,08869197 0,12439825 ! regulation of tumor necrosis factor production GO:0032680 12 12 0,000 0,08869197 0,12430365 ! regulation of steroid metabolic process GO:0019218 12 12 0,000 0,08869197 0,1242092 ! fibroblast growth factor receptor signaling pathway GO:0008543 12 12 0,000 0,08869197 0,12411489 ! pallium development GO:0021543 13 12 0,000 0,08869197 0,12402072 ! cell fate determination GO:0001709 12 12 0,000 0,08869197 0,12392669 ! somitogenesis GO:0001756 13 12 0,000 0,08869197 0,12383281 ! G1 phase GO:0051318 13 12 0,000 0,08869197 0,12373907 ! regulation of response to biotic stimulus GO:0002831 12 12 0,000 0,08869197 0,12364547 ! positive regulation of adaptive immune response GO:0002821 12 12 0,000 0,08869197 0,12355201 ! detection of light stimulus GO:0009583 13 12 0,000 0,08869197 0,12345869 ! synaptogenesis GO:0007416 12 12 0,000 0,08869197 0,12336551 ! fat-soluble vitamin metabolic process GO:0006775 12 12 0,000 0,08869197 0,12327248 ! neurotransmitter secretion GO:0007269 14 12 0,000 0,08869197 0,12317958 ! heme biosynthetic process GO:0006783 12 12 0,000 0,08869197 0,12308683 ! spermatid differentiation GO:0048515 13 12 0,000 0,08869197 0,12299421 GO:0007286|spermatid development, ! pyrimidine nucleotide biosynthetic process GO:0006221 12 12 0,000 0,08869197 0,12290173 ! neural tube closure GO:0001843 13 12 0,000 0,08869197 0,1228094 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! negative regulation of translation GO:0017148 12 12 0,000 0,08869197 0,1227172 ! regulation of microtubule polymerization or depolymerization GO:0031110 12 12 0,000 0,08869197 0,12262514 ! cellular monovalent inorganic cation homeostasis GO:0030004 12 12 0,000 0,08869197 0,12253321 ! positive regulation of cellular component organization GO:0051130 65 65 1,000 0,08909995 0,12300465 ! regulation of hormone levels GO:0010817 66 65 1,000 0,08909995 0,12291258 ! DNA packaging GO:0006323 66 66 1,000 0,09144557 0,12605398 ! negative regulation of protein metabolic process GO:0051248 66 66 1,000 0,09144557 0,12595977 ! Ras protein signal transduction GO:0007265 69 67 1,000 0,09380944 0,12911934 ! positive regulation of DNA replication GO:0045740 14 13 0,000 0,09572449 0,13165689 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 13 13 0,000 0,09572449 0,13155871 GO:0016444|somatic cell DNA recombination, ! negative regulation of actin filament polymerization GO:0030837 13 13 0,000 0,09572449 0,13146068 ! phenol metabolic process GO:0018958 13 13 0,000 0,09572449 0,1313628 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, GO:0009712|catechol metabolic process, ! G2/M transition of mitotic cell cycle GO:0000086 13 13 0,000 0,09572449 0,13126506 ! gluconeogenesis GO:0006094 13 13 0,000 0,09572449 0,13116746 ! 2'-deoxyribonucleotide metabolic process GO:0009394 13 13 0,000 0,09572449 0,13107001 GO:0019692|deoxyribose phosphate metabolic process, ! intra-Golgi vesicle-mediated transport GO:0006891 13 13 0,000 0,09572449 0,13097271 ! glycosaminoglycan biosynthetic process GO:0006024 13 13 0,000 0,09572449 0,13087554 ! keratinization GO:0031424 13 13 0,000 0,09572449 0,13077853 ! negative regulation of protein modification process GO:0031400 13 13 0,000 0,09572449 0,13068166 ! patterning of blood vessels GO:0001569 13 13 0,000 0,09572449 0,13058493 ! vasculogenesis GO:0001570 13 13 0,000 0,09572449 0,13048834 ! regulation of DNA recombination GO:0000018 13 13 0,000 0,09572449 0,1303919 ! regulation of nitric oxide biosynthetic process GO:0045428 13 13 0,000 0,09572449 0,13029559 ! negative regulation of DNA replication GO:0008156 13 13 0,000 0,09572449 0,13019943 ! multicellular organismal macromolecule metabolic process GO:0044259 13 13 0,000 0,09572449 0,13010342 ! multicellular organismal catabolic process GO:0044243 13 13 0,000 0,09572449 0,13000754 ! autophagy GO:0006914 13 13 0,000 0,09572449 0,12991181 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 13 13 0,000 0,09572449 0,12981621 ! regulation of endothelial cell migration GO:0010594 13 13 0,000 0,09572449 0,12972076 ! response to endoplasmic reticulum stress GO:0034976 13 13 0,000 0,09572449 0,12962545 ! negative regulation of protein kinase cascade GO:0010741 13 13 0,000 0,09572449 0,12953027 ! purine nucleoside monophosphate metabolic process GO:0009126 13 13 0,000 0,09572449 0,12943524 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of peptide secretion GO:0002791 13 13 0,000 0,09572449 0,12934035 ! nucleobase metabolic process GO:0009112 13 13 0,000 0,09572449 0,12924559 ! regulation of axonogenesis GO:0050770 14 13 0,000 0,09572449 0,12915098 ! positive regulation of neurogenesis GO:0050769 13 13 0,000 0,09572449 0,1290565 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 14 13 0,000 0,09572449 0,12896216 ! vasodilation GO:0042311 14 13 0,000 0,09572449 0,12886796 ! positive regulation of leukocyte mediated immunity GO:0002705 13 13 0,000 0,09572449 0,12877389 GO:0002708|positive regulation of lymphocyte mediated immunity, ! negative regulation of phosphorylation GO:0042326 13 13 0,000 0,09572449 0,12867997 ! glycosphingolipid metabolic process GO:0006687 13 13 0,000 0,09572449 0,12858618 GO:0006664|glycolipid metabolic process, ! neural crest cell migration GO:0001755 14 13 0,000 0,09572449 0,12849252 ! neutrophil chemotaxis GO:0030593 14 13 0,000 0,09572449 0,12839901 ! long-chain fatty acid transport GO:0015909 13 13 0,000 0,09572449 0,12830562 ! immunoglobulin production GO:0002377 13 13 0,000 0,09572449 0,12821238 GO:0002440|production of molecular mediator of immune response, ! negative regulation of Wnt receptor signaling pathway GO:0030178 13 13 0,000 0,09572449 0,12811927 ! cell-cell junction organization GO:0045216 13 13 0,000 0,09572449 0,12802629 ! negative regulation of myeloid cell differentiation GO:0045638 13 13 0,000 0,09572449 0,12793345 ! activation of JUN kinase activity GO:0007257 13 13 0,000 0,09572449 0,12784075 ! terpenoid metabolic process GO:0006721 13 13 0,000 0,09572449 0,12774818 ! purine nucleotide catabolic process GO:0006195 13 13 0,000 0,09572449 0,12765574 ! porphyrin biosynthetic process GO:0006779 13 13 0,000 0,09572449 0,12756344 GO:0033014|tetrapyrrole biosynthetic process, ! negative regulation of cytokine production GO:0001818 13 13 0,000 0,09572449 0,12747127 ! camera-type eye morphogenesis GO:0048593 13 13 0,000 0,09572449 0,12737923 ! pyrimidine nucleoside metabolic process GO:0006213 13 13 0,000 0,09572449 0,12728733 ! blastocyst development GO:0001824 13 13 0,000 0,09572449 0,12719555 ! telomere organization GO:0032200 13 13 0,000 0,09572449 0,12710392 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 13 13 0,000 0,09572449 0,12701241 ! regulation of amine transport GO:0051952 13 13 0,000 0,09572449 0,12692103 ! inner ear receptor cell differentiation GO:0060113 13 13 0,000 0,09572449 0,12682979 ! protein tetramerization GO:0051262 13 13 0,000 0,09572449 0,12673867 ! regulation of translation GO:0006417 69 69 1,000 0,09859035 0,13043935 ! sensory perception of sound GO:0007605 71 69 1,000 0,09859035 0,13034578 GO:0050954|sensory perception of mechanical stimulus, ! neuron fate commitment GO:0048663 14 14 0,000 0,10270375 0,13568675 ! sulfur amino acid metabolic process GO:0000096 14 14 0,000 0,10270375 0,13558955 ! regulation of interferon-gamma production GO:0032649 14 14 0,000 0,10270375 0,1354925 ! pyruvate metabolic process GO:0006090 14 14 0,000 0,10270375 0,13539558 ! cellular aldehyde metabolic process GO:0006081 14 14 0,000 0,10270375 0,1352988 ! cellular iron ion homeostasis GO:0006879 14 14 0,000 0,10270375 0,13520215 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 14 14 0,000 0,10270375 0,13510565 ! protein amino acid acylation GO:0043543 14 14 0,000 0,10270375 0,13500928 ! regulation of neuron projection development GO:0010975 15 14 0,000 0,10270375 0,13491306 ! protein amino acid deacetylation GO:0006476 14 14 0,000 0,10270375 0,13481696 ! aminoglycan biosynthetic process GO:0006023 14 14 0,000 0,10270375 0,13472101 ! vesicle docking GO:0048278 14 14 0,000 0,10270375 0,13462519 ! superoxide metabolic process GO:0006801 15 14 0,000 0,10270375 0,13452951 ! macromolecular complex disassembly GO:0032984 15 14 0,000 0,10270375 0,13443396 ! calcium-dependent cell-cell adhesion GO:0016339 14 14 0,000 0,10270375 0,13433855 ! mechanoreceptor differentiation GO:0042490 14 14 0,000 0,10270375 0,13424327 ! isoprenoid biosynthetic process GO:0008299 14 14 0,000 0,10270375 0,13414813 ! negative regulation of epithelial cell proliferation GO:0050680 14 14 0,000 0,10270375 0,13405313 ! immune response-activating cell surface receptor signaling pathway GO:0002429 14 14 0,000 0,10270375 0,13395826 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 14 14 0,000 0,10270375 0,13386352 ! actin polymerization or depolymerization GO:0008154 15 14 0,000 0,10270375 0,13376892 ! D-ribose metabolic process GO:0006014 14 14 0,000 0,10270375 0,13367445 ! negative regulation of phosphorus metabolic process GO:0010563 14 14 0,000 0,10270375 0,13358011 GO:0045936|negative regulation of phosphate metabolic process, ! primary neural tube formation GO:0014020 15 14 0,000 0,10270375 0,13348591 ! peptide cross-linking GO:0018149 14 14 0,000 0,10270375 0,13339184 ! vitamin biosynthetic process GO:0009110 14 14 0,000 0,10270375 0,1332979 ! regulation of vasoconstriction GO:0019229 14 14 0,000 0,10270375 0,13320409 ! formation of primary germ layer GO:0001704 14 14 0,000 0,10270375 0,13311042 GO:0001707|mesoderm formation, ! proteoglycan biosynthetic process GO:0030166 14 14 0,000 0,10270375 0,13301688 ! regulation of blood coagulation GO:0030193 15 14 0,000 0,10270375 0,13292347 ! group transfer coenzyme metabolic process GO:0006752 14 14 0,000 0,10270375 0,13283019 ! neuromuscular process controlling balance GO:0050885 14 14 0,000 0,10270375 0,13273704 ! aspartate family amino acid metabolic process GO:0009066 14 14 0,000 0,10270375 0,13264402 ! negative regulation of protein polymerization GO:0032272 14 14 0,000 0,10270375 0,13255113 ! calcium ion homeostasis GO:0055074 71 71 1,000 0,10343947 0,13340724 GO:0006874|cellular calcium ion homeostasis, ! secretion by cell GO:0032940 75 72 1,000 0,10588864 0,13647046 ! sensory organ development GO:0007423 72 72 1,000 0,10588864 0,1363751 ! regulation of cytokine production GO:0001817 72 72 1,000 0,10588864 0,13627986 ! protein import into nucleus, translocation GO:0000060 15 15 0,000 0,10963016 0,14099678 ! positive regulation of fibroblast proliferation GO:0048146 15 15 0,000 0,10963016 0,14089845 ! negative regulation of actin filament depolymerization GO:0030835 15 15 0,000 0,10963016 0,14080027 ! positive regulation of ossification GO:0045778 15 15 0,000 0,10963016 0,14070222 GO:0046852|positive regulation of bone remodeling, GO:0034105|positive regulation of tissue remodeling, ! negative regulation of protein complex assembly GO:0031333 15 15 0,000 0,10963016 0,1406043 ! protein amino acid O-linked glycosylation GO:0006493 15 15 0,000 0,10963016 0,14050652 ! cellular polysaccharide biosynthetic process GO:0033692 15 15 0,000 0,10963016 0,14040888 ! proteoglycan metabolic process GO:0006029 15 15 0,000 0,10963016 0,14031138 ! odontogenesis of dentine-containing tooth GO:0042475 15 15 0,000 0,10963016 0,14021401 ! detection of stimulus involved in sensory perception GO:0050906 16 15 0,000 0,10963016 0,14011677 ! regulation of smooth muscle contraction GO:0006940 15 15 0,000 0,10963016 0,14001967 ! deoxyribonucleotide metabolic process GO:0009262 15 15 0,000 0,10963016 0,1399227 ! complement activation, classical pathway GO:0006958 15 15 0,000 0,10963016 0,13982587 ! ER-nuclear signaling pathway GO:0006984 15 15 0,000 0,10963016 0,13972917 ! heme metabolic process GO:0042168 15 15 0,000 0,10963016 0,13963261 ! mesoderm morphogenesis GO:0048332 15 15 0,000 0,10963016 0,13953618 ! response to starvation GO:0042594 15 15 0,000 0,10963016 0,13943988 ! response to mechanical stimulus GO:0009612 15 15 0,000 0,10963016 0,13934371 ! hydrogen peroxide metabolic process GO:0042743 15 15 0,000 0,10963016 0,13924768 ! regulation of biomineral formation GO:0070167 15 15 0,000 0,10963016 0,13915178 GO:0030500|regulation of bone mineralization, ! cyclic nucleotide biosynthetic process GO:0009190 15 15 0,000 0,10963016 0,13905601 ! cholesterol biosynthetic process GO:0006695 15 15 0,000 0,10963016 0,13896037 ! phospholipid transport GO:0015914 15 15 0,000 0,10963016 0,13886487 ! regulation of cytokine secretion GO:0050707 15 15 0,000 0,10963016 0,13876949 ! glutathione metabolic process GO:0006749 16 15 0,000 0,10963016 0,13867425 ! positive regulation of myeloid cell differentiation GO:0045639 16 15 0,000 0,10963016 0,13857914 ! somatic diversification of immune receptors GO:0002200 15 15 0,000 0,10963016 0,13848416 ! positive regulation of immune effector process GO:0002699 15 15 0,000 0,10963016 0,1383893 ! electron transport chain GO:0022900 75 74 1,000 0,11083426 0,13981351 ! coenzyme metabolic process GO:0006732 75 74 1,000 0,11083426 0,13971788 ! regulation of synaptic plasticity GO:0048167 16 16 0,000 0,1165041 0,1467649 ! spliceosomal snRNP biogenesis GO:0000387 16 16 0,000 0,1165041 0,14666465 ! learning GO:0007612 16 16 0,000 0,1165041 0,14656454 ! circadian rhythm GO:0007623 16 16 0,000 0,1165041 0,14646457 ! inner ear morphogenesis GO:0042472 16 16 0,000 0,1165041 0,14636473 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 16 16 0,000 0,1165041 0,14626502 ! vacuole organization GO:0007033 16 16 0,000 0,1165041 0,14616546 ! positive regulation of cytoskeleton organization GO:0051495 16 16 0,000 0,1165041 0,14606602 ! vesicle targeting GO:0006903 17 16 0,000 0,1165041 0,14596673 ! segmentation GO:0035282 17 16 0,000 0,1165041 0,14586756 ! fatty acid beta-oxidation GO:0006635 16 16 0,000 0,1165041 0,14576854 ! triglyceride metabolic process GO:0006641 16 16 0,000 0,1165041 0,14566964 ! iron ion homeostasis GO:0055072 16 16 0,000 0,1165041 0,14557088 ! regulation of myeloid leukocyte differentiation GO:0002761 17 16 0,000 0,1165041 0,14547226 ! regulation of systemic arterial blood pressure GO:0003073 17 16 0,000 0,1165041 0,14537377 ! cell fate specification GO:0001708 16 16 0,000 0,1165041 0,14527541 ! pentose metabolic process GO:0019321 16 16 0,000 0,1165041 0,14517718 ! fatty acid transport GO:0015908 16 16 0,000 0,1165041 0,14507909 ! cellular response to nutrient levels GO:0031669 16 16 0,000 0,1165041 0,14498113 ! regulation of microtubule cytoskeleton organization GO:0070507 16 16 0,000 0,1165041 0,1448833 ! ethanolamine and derivative metabolic process GO:0042439 17 16 0,000 0,1165041 0,14478561 ! polyol metabolic process GO:0019751 16 16 0,000 0,1165041 0,14468804 ! serine family amino acid metabolic process GO:0009069 16 16 0,000 0,1165041 0,14459061 ! glutamine family amino acid catabolic process GO:0009065 17 16 0,000 0,1165041 0,14449331 ! porphyrin metabolic process GO:0006778 16 16 0,000 0,1165041 0,14439614 GO:0033013|tetrapyrrole metabolic process, ! embryonic epithelial tube formation GO:0001838 17 16 0,000 0,1165041 0,1442991 GO:0001841|neural tube formation, ! regulation of JUN kinase activity GO:0043506 17 16 0,000 0,1165041 0,14420219 GO:0043507|positive regulation of JUN kinase activity, ! regulation of cell morphogenesis involved in differentiation GO:0010769 17 16 0,000 0,1165041 0,14410541 ! response to xenobiotic stimulus GO:0009410 16 16 0,000 0,1165041 0,14400876 ! regulation of coagulation GO:0050818 17 16 0,000 0,1165041 0,14391224 ! cellular metal ion homeostasis GO:0006875 77 77 1,000 0,11836532 0,14611338 ! microtubule-based movement GO:0007018 82 78 1,000 0,12090424 0,1491476 ! metal ion homeostasis GO:0055065 78 78 1,000 0,12090424 0,14904783 ! regulation of fibroblast proliferation GO:0048145 17 17 0,000 0,12332596 0,15193165 ! regulation of actin filament depolymerization GO:0030834 17 17 0,000 0,12332596 0,15183016 ! regulation of transmembrane transport GO:0034762 17 17 0,000 0,12332596 0,15172881 ! nucleotide-excision repair, DNA damage removal GO:0000718 18 17 0,000 0,12332596 0,15162759 ! leukocyte adhesion GO:0007159 17 17 0,000 0,12332596 0,1515265 ! sensory perception of smell GO:0007608 17 17 0,000 0,12332596 0,15142555 ! tissue remodeling GO:0048771 17 17 0,000 0,12332596 0,15132474 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 17 17 0,000 0,12332596 0,15122405 ! embryonic skeletal system morphogenesis GO:0048704 17 17 0,000 0,12332596 0,15112351 ! cellular carbohydrate biosynthetic process GO:0034637 17 17 0,000 0,12332596 0,15102309 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 17 17 0,000 0,12332596 0,15092281 ! neural crest cell development GO:0014032 19 17 0,000 0,12332596 0,15082266 GO:0014033|neural crest cell differentiation, ! negative regulation of cell development GO:0010721 18 17 0,000 0,12332596 0,15072265 GO:0050768|negative regulation of neurogenesis, ! immune response-activating signal transduction GO:0002757 17 17 0,000 0,12332596 0,15062276 GO:0002764|immune response-regulating signal transduction, ! cell recognition GO:0008037 18 17 0,000 0,12332596 0,15052301 ! regulation of oxidoreductase activity GO:0051341 17 17 0,000 0,12332596 0,1504234 ! myeloid leukocyte activation GO:0002274 18 17 0,000 0,12332596 0,15032391 ! adult locomotory behavior GO:0008344 17 17 0,000 0,12332596 0,15022456 ! embryonic organ development GO:0048568 17 17 0,000 0,12332596 0,15012533 ! regulation of calcium ion transport GO:0051924 17 17 0,000 0,12332596 0,15002624 ! liver development GO:0001889 17 17 0,000 0,12332596 0,14992728 ! gene silencing GO:0016458 17 17 0,000 0,12332596 0,14982845 ! MAPKKK cascade GO:0000165 82 81 1,000 0,12860174 0,15613506 ! tube development GO:0035295 83 81 1,000 0,12860174 0,15603227 ! lymphocyte activation GO:0046649 82 81 1,000 0,12860174 0,15592962 ! mRNA export from nucleus GO:0006406 18 18 0,000 0,13009614 0,15763786 ! regulation of cell projection organization GO:0031344 19 18 0,000 0,13009614 0,15753429 ! regulation of cellular catabolic process GO:0031329 18 18 0,000 0,13009614 0,15743085 ! regulation of metal ion transport GO:0010959 18 18 0,000 0,13009614 0,15732755 ! membrane docking GO:0022406 18 18 0,000 0,13009614 0,15722439 ! response to calcium ion GO:0051592 18 18 0,000 0,13009614 0,15712136 ! negative regulation of response to external stimulus GO:0032102 18 18 0,000 0,13009614 0,15701846 ! cholesterol homeostasis GO:0042632 18 18 0,000 0,13009614 0,1569157 GO:0055092|sterol homeostasis, ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 18 18 0,000 0,13009614 0,15681307 ! striated muscle contraction GO:0006941 18 18 0,000 0,13009614 0,15671058 ! neutral lipid metabolic process GO:0006638 18 18 0,000 0,13009614 0,15660822 GO:0006639|acylglycerol metabolic process, ! ceramide metabolic process GO:0006672 18 18 0,000 0,13009614 0,156506 GO:0046519|sphingoid metabolic process, ! ribonucleoside monophosphate metabolic process GO:0009161 18 18 0,000 0,13009614 0,15640391 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! telencephalon development GO:0021537 19 18 0,000 0,13009614 0,15630195 ! hexose biosynthetic process GO:0019319 18 18 0,000 0,13009614 0,15620012 ! negative regulation of MAP kinase activity GO:0043407 18 18 0,000 0,13009614 0,15609843 ! cellular response to extracellular stimulus GO:0031668 18 18 0,000 0,13009614 0,15599687 ! BMP signaling pathway GO:0030509 18 18 0,000 0,13009614 0,15589544 ! regulation of microtubule-based process GO:0032886 18 18 0,000 0,13009614 0,15579414 ! symbiosis, encompassing mutualism through parasitism GO:0044403 18 18 0,000 0,13009614 0,15569298 ! establishment of vesicle localization GO:0051650 19 18 0,000 0,13009614 0,15559195 ! cellular amino acid derivative metabolic process GO:0006575 87 84 1,000 0,13641313 0,16304111 ! DNA damage checkpoint GO:0000077 19 19 0,000 0,13681501 0,16341547 ! activation of adenylate cyclase activity GO:0007190 19 19 0,000 0,13681501 0,16330963 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 19 19 0,000 0,13681501 0,16320393 GO:0006956|complement activation, ! negative regulation of DNA metabolic process GO:0051053 19 19 0,000 0,13681501 0,16309836 ! glial cell differentiation GO:0010001 19 19 0,000 0,13681501 0,16299294 ! regulation of pH GO:0006885 19 19 0,000 0,13681501 0,16288764 ! feeding behavior GO:0007631 19 19 0,000 0,13681501 0,16278249 ! regulation of endothelial cell proliferation GO:0001936 19 19 0,000 0,13681501 0,16267746 ! peroxisome organization GO:0007031 19 19 0,000 0,13681501 0,16257258 ! ribonucleoside metabolic process GO:0009119 19 19 0,000 0,13681501 0,16246783 ! regulation of lymphocyte mediated immunity GO:0002706 19 19 0,000 0,13681501 0,16236321 ! nuclear-transcribed mRNA catabolic process GO:0000956 19 19 0,000 0,13681501 0,16225873 ! hormone biosynthetic process GO:0042446 19 19 0,000 0,13681501 0,16215439 ! biogenic amine biosynthetic process GO:0042401 20 19 0,000 0,13681501 0,16205017 ! dorsal/ventral pattern formation GO:0009953 19 19 0,000 0,13681501 0,1619461 ! eye morphogenesis GO:0048592 19 19 0,000 0,13681501 0,16184215 ! regulation of cell shape GO:0008360 21 19 0,000 0,13681501 0,16173834 ! placenta development GO:0001890 19 19 0,000 0,13681501 0,16163466 ! vesicle localization GO:0051648 20 19 0,000 0,13681501 0,16153112 ! nitrogen compound biosynthetic process GO:0044271 86 85 1,000 0,13904066 0,16405374 ! negative regulation of cell adhesion GO:0007162 21 20 0,000 0,14348296 0,16918689 ! establishment or maintenance of cell polarity GO:0007163 21 20 0,000 0,14348296 0,16907871 ! organic ether metabolic process GO:0018904 20 20 0,000 0,14348296 0,16897067 GO:0006662|glycerol ether metabolic process, ! cytoskeleton-dependent intracellular transport GO:0030705 20 20 0,000 0,14348296 0,16886277 ! neural tube development GO:0021915 21 20 0,000 0,14348296 0,16875501 ! phagocytosis GO:0006909 21 20 0,000 0,14348296 0,16864739 ! positive regulation of gene-specific transcription GO:0043193 20 20 0,000 0,14348296 0,1685399 ! protein targeting to membrane GO:0006612 22 20 0,000 0,14348296 0,16843255 ! cyclic nucleotide metabolic process GO:0009187 20 20 0,000 0,14348296 0,16832534 ! chromatin remodeling GO:0006338 20 20 0,000 0,14348296 0,16821826 ! detection of abiotic stimulus GO:0009582 21 20 0,000 0,14348296 0,16811132 ! lipid oxidation GO:0034440 20 20 0,000 0,14348296 0,16800451 GO:0019395|fatty acid oxidation, ! monosaccharide biosynthetic process GO:0046364 20 20 0,000 0,14348296 0,16789784 ! RNA modification GO:0009451 20 20 0,000 0,14348296 0,16779131 ! single fertilization GO:0007338 21 20 0,000 0,14348296 0,16768491 ! male gamete generation GO:0048232 90 88 1,000 0,14698993 0,17167455 GO:0007283|spermatogenesis, ! cellular di-, tri-valent inorganic cation homeostasis GO:0030005 89 89 1,000 0,14966085 0,17468331 ! mRNA catabolic process GO:0006402 21 21 0,000 0,15010037 0,17508543 ! positive regulation of adenylate cyclase activity GO:0045762 21 21 0,000 0,15010037 0,17497469 GO:0051349|positive regulation of lyase activity, GO:0031281|positive regulation of cyclase activity, ! receptor-mediated endocytosis GO:0006898 21 21 0,000 0,15010037 0,17486408 ! morphogenesis of embryonic epithelium GO:0016331 22 21 0,000 0,15010037 0,17475362 ! ear morphogenesis GO:0042471 21 21 0,000 0,15010037 0,1746433 ! organic anion transport GO:0015711 21 21 0,000 0,15010037 0,17453311 ! cholesterol transport GO:0030301 21 21 0,000 0,15010037 0,17442306 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 22 21 0,000 0,15010037 0,17431316 ! regulation of Rab protein signal transduction GO:0032483 21 21 0,000 0,15010037 0,17420339 GO:0032313|regulation of Rab GTPase activity, ! DNA integrity checkpoint GO:0031570 21 21 0,000 0,15010037 0,17409376 ! regulation of leukocyte mediated immunity GO:0002703 21 21 0,000 0,15010037 0,17398426 ! negative regulation of hydrolase activity GO:0051346 21 21 0,000 0,15010037 0,17387491 ! regulation of Ras protein signal transduction GO:0046578 90 90 1,000 0,15234184 0,17636056 ! brain development GO:0007420 91 90 1,000 0,15234184 0,17624985 ! negative regulation of cell cycle GO:0045786 92 91 1,000 0,15503258 0,17925035 ! di-, tri-valent inorganic cation homeostasis GO:0055066 91 91 1,000 0,15503258 0,17913796 ! RNA export from nucleus GO:0006405 22 22 0,000 0,15666761 0,18091378 ! regulation of ion transport GO:0043269 22 22 0,000 0,15666761 0,1808005 ! embryonic skeletal system development GO:0048706 22 22 0,000 0,15666761 0,18068736 ! pigment biosynthetic process GO:0046148 22 22 0,000 0,15666761 0,18057436 ! respiratory gaseous exchange GO:0007585 22 22 0,000 0,15666761 0,1804615 ! erythrocyte differentiation GO:0030218 23 22 0,000 0,15666761 0,18034878 ! sterol biosynthetic process GO:0016126 22 22 0,000 0,15666761 0,1802362 ! detection of external stimulus GO:0009581 23 22 0,000 0,15666761 0,18012377 ! neuron migration GO:0001764 22 22 0,000 0,15666761 0,18001147 ! regulation of Wnt receptor signaling pathway GO:0030111 23 22 0,000 0,15666761 0,17989931 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 22 22 0,000 0,15666761 0,1797873 ! fatty acid catabolic process GO:0009062 23 22 0,000 0,15666761 0,17967542 ! cytokine production GO:0001816 22 22 0,000 0,15666761 0,17956368 ! pyrimidine nucleotide metabolic process GO:0006220 22 22 0,000 0,15666761 0,17945208 ! energy derivation by oxidation of organic compounds GO:0015980 94 92 1,000 0,15773279 0,18055996 ! positive regulation of immune system process GO:0002684 92 92 1,000 0,15773279 0,18044788 ! blood vessel development GO:0001568 95 94 1,000 0,1631604 0,18654132 ! cofactor metabolic process GO:0051186 95 94 1,000 0,1631604 0,18642567 ! epithelial cell differentiation GO:0030855 23 23 0,000 0,16318505 0,18633832 ! viral infectious cycle GO:0019058 23 23 0,000 0,16318505 0,18622294 ! negative regulation of protein complex disassembly GO:0043242 23 23 0,000 0,16318505 0,1861077 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 23 23 0,000 0,16318505 0,18599261 ! mitotic cell cycle checkpoint GO:0007093 24 23 0,000 0,16318505 0,18587765 ! induction of apoptosis by extracellular signals GO:0008624 23 23 0,000 0,16318505 0,18576284 ! regulation of ARF protein signal transduction GO:0032012 23 23 0,000 0,16318505 0,18564818 ! monovalent inorganic cation homeostasis GO:0055067 23 23 0,000 0,16318505 0,18553365 ! lipid homeostasis GO:0055088 23 23 0,000 0,16318505 0,18541926 ! calcium-mediated signaling GO:0019722 23 23 0,000 0,16318505 0,18530502 ! regulation of JNK cascade GO:0046328 25 23 0,000 0,16318505 0,18519091 ! cell projection assembly GO:0030031 25 23 0,000 0,16318505 0,18507695 ! vasculature development GO:0001944 97 96 1,000 0,16862232 0,19112604 ! gliogenesis GO:0042063 24 24 0,000 0,16965307 0,19217615 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 26 24 0,000 0,16965307 0,19205811 ! glucose homeostasis GO:0042593 24 24 0,000 0,16965307 0,19194021 GO:0033500|carbohydrate homeostasis, ! heterocycle biosynthetic process GO:0018130 24 24 0,000 0,16965307 0,19182245 ! nucleotide catabolic process GO:0009166 24 24 0,000 0,16965307 0,19170484 ! erythrocyte homeostasis GO:0034101 25 24 0,000 0,16965307 0,19158738 ! fertilization GO:0009566 25 24 0,000 0,16965307 0,19147006 ! androgen receptor signaling pathway GO:0030521 24 24 0,000 0,16965307 0,19135288 ! glucan metabolic process GO:0044042 25 24 0,000 0,16965307 0,19123584 GO:0006073|cellular glucan metabolic process, GO:0005977|glycogen metabolic process, ! endocytosis GO:0006897 99 98 1,000 0,17411631 0,19614692 GO:0010324|membrane invagination, ! glycoprotein metabolic process GO:0009100 99 98 1,000 0,17411631 0,1960271 ! regulation of actin filament polymerization GO:0030833 25 25 0,000 0,17607203 0,1981079 ! protein amino acid N-linked glycosylation GO:0006487 25 25 0,000 0,17607203 0,19798703 ! regulation of gene-specific transcription GO:0032583 25 25 0,000 0,17607203 0,19786631 ! sensory perception of chemical stimulus GO:0007606 25 25 0,000 0,17607203 0,19774573 ! cellular component disassembly GO:0022411 26 25 0,000 0,17607203 0,1976253 ! alcohol biosynthetic process GO:0046165 25 25 0,000 0,17607203 0,19750502 ! polysaccharide biosynthetic process GO:0000271 25 25 0,000 0,17607203 0,19738488 ! excretion GO:0007588 25 25 0,000 0,17607203 0,19726489 ! gastrulation GO:0007369 25 25 0,000 0,17607203 0,19714504 ! regulation of endocytosis GO:0030100 25 25 0,000 0,17607203 0,19702534 ! negative regulation of transcription from RNA polymerase II promoter GO:0000122 103 100 1,000 0,17964013 0,2008961 ! hemopoiesis GO:0030097 104 100 1,000 0,17964013 0,20077427 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 26 26 0,000 0,18244229 0,20378251 ! induction of apoptosis by intracellular signals GO:0008629 26 26 0,000 0,18244229 0,20365908 ! cellular defense response GO:0006968 26 26 0,000 0,18244229 0,2035358 ! positive regulation of cytokine biosynthetic process GO:0042108 26 26 0,000 0,18244229 0,20341267 ! regulation of blood vessel size GO:0050880 27 26 0,000 0,18244229 0,20328969 GO:0035150|regulation of tube size, ! chloride transport GO:0006821 27 27 0,000 0,18876423 0,21020693 ! regulation of neurotransmitter levels GO:0001505 31 27 0,000 0,18876423 0,21008 ! energy reserve metabolic process GO:0006112 28 27 0,000 0,18876423 0,20995321 ! learning or memory GO:0007611 28 27 0,000 0,18876423 0,20982658 ! monocarboxylic acid transport GO:0015718 27 27 0,000 0,18876423 0,20970011 ! peptide metabolic process GO:0006518 29 27 0,000 0,18876423 0,20957378 ! activation of caspase activity GO:0006919 27 27 0,000 0,18876423 0,20944761 ! inner ear development GO:0048839 27 27 0,000 0,18876423 0,20932159 ! isoprenoid metabolic process GO:0006720 27 27 0,000 0,18876423 0,20919572 ! glutamine family amino acid metabolic process GO:0009064 28 27 0,000 0,18876423 0,20907 ! tRNA aminoacylation for protein translation GO:0006418 28 28 0,000 0,1950382 0,21588913 GO:0043038|amino acid activation, GO:0043039|tRNA aminoacylation, ! stress-activated protein kinase signaling pathway GO:0031098 28 28 0,000 0,1950382 0,21575954 GO:0007254|JNK cascade, ! neuromuscular process GO:0050905 28 28 0,000 0,1950382 0,21563011 ! regulation of muscle contraction GO:0006937 28 28 0,000 0,1950382 0,21550084 ! sulfur compound biosynthetic process GO:0044272 28 28 0,000 0,1950382 0,21537172 ! keratinocyte differentiation GO:0030216 28 28 0,000 0,1950382 0,21524275 ! histone modification GO:0016570 28 28 0,000 0,1950382 0,21511394 ! cartilage development GO:0051216 29 28 0,000 0,1950382 0,21498529 ! viral reproductive process GO:0022415 29 29 0,000 0,20126455 0,22171582 ! tRNA processing GO:0008033 29 29 0,000 0,20126455 0,22158337 ! covalent chromatin modification GO:0016569 29 29 0,000 0,20126455 0,22145108 ! adult behavior GO:0030534 30 29 0,000 0,20126455 0,22131895 ! regulation of protein polymerization GO:0032271 29 29 0,000 0,20126455 0,22118698 ! transition metal ion transport GO:0000041 31 30 0,000 0,20744365 0,22784186 ! RNA catabolic process GO:0006401 30 30 0,000 0,20744365 0,22770616 ! ER to Golgi vesicle-mediated transport GO:0006888 30 30 0,000 0,20744365 0,22757062 ! positive regulation of peptidase activity GO:0010952 30 30 0,000 0,20744365 0,22743524 GO:0043280|positive regulation of caspase activity, ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 30 30 0,000 0,20744365 0,22730002 ! neuropeptide signaling pathway GO:0007218 30 30 0,000 0,20744365 0,22716497 ! activation of phospholipase C activity GO:0007202 30 30 0,000 0,20744365 0,22703007 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein complex disassembly GO:0043244 30 30 0,000 0,20744365 0,22689533 ! skeletal system morphogenesis GO:0048705 31 30 0,000 0,20744365 0,22676076 ! vascular process in circulatory system GO:0003018 31 30 0,000 0,20744365 0,22662634 ! immunoglobulin mediated immune response GO:0016064 30 30 0,000 0,20744365 0,22649208 GO:0019724|B cell mediated immunity, ! cellular amino acid derivative biosynthetic process GO:0042398 31 30 0,000 0,20744365 0,22635799 ! regulation of translational initiation GO:0006446 31 31 0,000 0,21357583 0,2329114 ! membrane fusion GO:0006944 31 31 0,000 0,21357583 0,23277366 ! negative regulation of cytoskeleton organization GO:0051494 32 31 0,000 0,21357583 0,23263609 ! positive regulation of phospholipase activity GO:0010518 31 31 0,000 0,21357583 0,23249868 ! ion transmembrane transport GO:0034220 31 31 0,000 0,21357583 0,23236143 GO:0015985|energy coupled proton transport, down electrochemical gradient, GO:0015986|ATP synthesis coupled proton transport, ! nucleoside metabolic process GO:0009116 31 31 0,000 0,21357583 0,23222434 ! regulation of heart contraction GO:0008016 31 31 0,000 0,21357583 0,23208742 ! sphingolipid metabolic process GO:0006665 31 31 0,000 0,21357583 0,23195065 ! camera-type eye development GO:0043010 31 31 0,000 0,21357583 0,23181405 ! ribonucleoprotein complex assembly GO:0022618 32 31 0,000 0,21357583 0,23167761 ! epidermal cell differentiation GO:0009913 31 31 0,000 0,21357583 0,23154133 ! regulation of myeloid cell differentiation GO:0045637 32 31 0,000 0,21357583 0,23140521 ! cell redox homeostasis GO:0045454 32 32 0,000 0,21966146 0,23785903 ! lipid modification GO:0030258 32 32 0,000 0,21966146 0,23771936 ! regulation of phospholipase activity GO:0010517 32 32 0,000 0,21966146 0,23757986 ! glycosaminoglycan metabolic process GO:0030203 34 32 0,000 0,21966146 0,23744051 ! regulation of vesicle-mediated transport GO:0060627 33 32 0,000 0,21966146 0,23730133 ! cell maturation GO:0048469 32 32 0,000 0,21966146 0,23716232 ! nuclear export GO:0051168 32 32 0,000 0,21966146 0,23702346 ! positive regulation of lipase activity GO:0060193 32 32 0,000 0,21966146 0,23688477 ! regulation of cellular response to stress GO:0080135 35 33 0,000 0,22570088 0,2432554 ! amino acid transport GO:0006865 33 33 0,000 0,22570088 0,24311322 ! regulation of protein complex assembly GO:0043254 33 33 0,000 0,22570088 0,24297122 ! membrane lipid metabolic process GO:0006643 33 33 0,000 0,22570088 0,24282938 ! regulation of synaptic transmission GO:0050804 33 33 0,000 0,22570088 0,24268771 ! cellular polysaccharide metabolic process GO:0044264 35 34 0,000 0,23169444 0,24898708 ! coenzyme biosynthetic process GO:0009108 34 34 0,000 0,23169444 0,24884198 ! nucleoside monophosphate biosynthetic process GO:0009124 34 34 0,000 0,23169444 0,24869706 ! regulation of lipid metabolic process GO:0019216 34 34 0,000 0,23169444 0,2485523 ! negative regulation of response to stimulus GO:0048585 34 34 0,000 0,23169444 0,2484077 ! viral reproduction GO:0016032 34 34 0,000 0,23169444 0,24826328 ! detection of stimulus GO:0051606 36 34 0,000 0,23169444 0,24811903 ! mesoderm development GO:0007498 35 35 0,000 0,23764246 0,25434092 ! regulation of cell morphogenesis GO:0022604 38 35 0,000 0,23764246 0,2541933 ! inorganic anion transport GO:0015698 35 35 0,000 0,23764246 0,25404586 ! hydrogen transport GO:0006818 36 36 0,000 0,2435453 0,26020521 GO:0015992|proton transport, ! aminoglycan metabolic process GO:0006022 38 36 0,000 0,2435453 0,26005446 ! embryonic limb morphogenesis GO:0030326 36 36 0,000 0,2435453 0,25990388 GO:0035113|embryonic appendage morphogenesis, ! RNA elongation from RNA polymerase II promoter GO:0006368 36 36 0,000 0,2435453 0,25975347 ! heterocycle catabolic process GO:0046700 36 36 0,000 0,2435453 0,25960324 ! integrin-mediated signaling pathway GO:0007229 36 36 0,000 0,2435453 0,25945318 ! regulation of transmission of nerve impulse GO:0051969 36 36 0,000 0,2435453 0,25930329 ! regulation of lipase activity GO:0060191 36 36 0,000 0,2435453 0,25915358 ! activation of immune response GO:0002253 36 36 0,000 0,2435453 0,25900404 ! negative regulation of protein kinase activity GO:0006469 37 37 0,000 0,2494033 0,2650809 ! lung development GO:0030324 38 37 0,000 0,2494033 0,26492811 ! lymphocyte mediated immunity GO:0002449 37 37 0,000 0,2494033 0,2647755 ! eye development GO:0001654 37 37 0,000 0,2494033 0,26462307 ! DNA damage response, signal transduction GO:0042770 37 37 0,000 0,2494033 0,26447081 ! ATP synthesis coupled electron transport GO:0042773 37 37 0,000 0,2494033 0,26431873 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! adaptive immune response GO:0002250 37 37 0,000 0,2494033 0,26416682 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! neurotransmitter transport GO:0006836 40 38 0,000 0,25521677 0,27016916 ! cellular hormone metabolic process GO:0034754 39 38 0,000 0,25521677 0,27001407 ! exocytosis GO:0006887 40 38 0,000 0,25521677 0,26985916 ! negative regulation of kinase activity GO:0033673 38 38 0,000 0,25521677 0,26970442 ! RNA elongation GO:0006354 38 38 0,000 0,25521677 0,26954986 ! regulation of neurological system process GO:0031644 38 38 0,000 0,25521677 0,26939548 ! steroid hormone receptor signaling pathway GO:0030518 38 38 0,000 0,25521677 0,26924128 ! respiratory tube development GO:0030323 40 39 0,000 0,26098607 0,27517009 ! response to unfolded protein GO:0006986 39 39 0,000 0,26098607 0,27501276 ! nucleoside monophosphate metabolic process GO:0009123 39 39 0,000 0,26098607 0,27485561 ! intracellular protein transmembrane transport GO:0065002 39 39 0,000 0,26098607 0,27469864 ! respiratory system development GO:0060541 40 39 0,000 0,26098607 0,27454185 ! developmental maturation GO:0021700 39 39 0,000 0,26098607 0,27438524 ! limb development GO:0060173 39 39 0,000 0,26098607 0,2742288 GO:0048736|appendage development, GO:0035107|appendage morphogenesis, ! DNA catabolic process GO:0006308 41 40 0,000 0,26671151 0,28008508 ! negative regulation of transferase activity GO:0051348 40 40 0,000 0,26671151 0,27992557 ! myeloid cell differentiation GO:0030099 42 40 0,000 0,26671151 0,27976625 ! cell cycle checkpoint GO:0000075 42 41 0,000 0,27239342 0,28556375 ! elevation of cytosolic calcium ion concentration GO:0007204 41 41 0,000 0,27239342 0,28540141 ! regulation of caspase activity GO:0043281 41 41 0,000 0,27239342 0,28523925 ! regulation of Ras GTPase activity GO:0032318 41 41 0,000 0,27239342 0,28507727 ! respiratory electron transport chain GO:0022904 43 42 0,000 0,27803213 0,29081341 ! regulation of endopeptidase activity GO:0052548 42 42 0,000 0,27803213 0,29064845 ! cytosolic calcium ion homeostasis GO:0051480 42 42 0,000 0,27803213 0,29048369 ! forebrain development GO:0030900 43 42 0,000 0,27803213 0,29031911 ! mRNA transport GO:0051028 44 44 0,000 0,28918124 0,30178993 ! protein import into nucleus GO:0006606 44 44 0,000 0,28918124 0,30161914 ! homophilic cell adhesion GO:0007156 45 45 0,000 0,29469227 0,30719335 ! steroid biosynthetic process GO:0006694 46 45 0,000 0,29469227 0,3070197 ! nuclear import GO:0051170 45 45 0,000 0,29469227 0,30684624 ! Wnt receptor signaling pathway GO:0016055 46 45 0,000 0,29469227 0,30667298 ! regulation of peptidase activity GO:0052547 46 46 0,000 0,30016137 0,31218815 ! transcription initiation from RNA polymerase II promoter GO:0006367 46 46 0,000 0,30016137 0,31201207 ! amine transport GO:0015837 47 47 0,000 0,30558885 0,31747478 ! calcium ion transport GO:0006816 48 48 0,000 0,31097504 0,32288845 ! protein localization in nucleus GO:0034504 48 48 0,000 0,31097504 0,32270664 ! cellular lipid catabolic process GO:0044242 50 49 0,000 0,31632023 0,32806875 ! divalent metal ion transport GO:0070838 49 49 0,000 0,31632023 0,32788424 ! cofactor biosynthetic process GO:0051188 49 49 0,000 0,31632023 0,32769993 ! chromatin assembly GO:0031497 50 50 0,000 0,32162472 0,33300807 GO:0006334|nucleosome assembly, ! RNA transport GO:0050658 50 50 0,000 0,32162472 0,33282109 GO:0050657|nucleic acid transport, GO:0051236|establishment of RNA localization, ! transcription initiation GO:0006352 50 50 0,000 0,32162472 0,33263432 ! anterior/posterior pattern formation GO:0009952 51 50 0,000 0,32162472 0,33244777 ! biogenic amine metabolic process GO:0006576 52 51 0,000 0,32688884 0,33769962 ! positive regulation of immune response GO:0050778 51 51 0,000 0,32688884 0,33751043 ! rRNA metabolic process GO:0016072 51 51 0,000 0,32688884 0,33732146 GO:0006364|rRNA processing, ! protein-DNA complex assembly GO:0065004 51 51 0,000 0,32688884 0,3371327 ! ATP biosynthetic process GO:0006754 51 51 0,000 0,32688884 0,33694414 ! RNA localization GO:0006403 52 52 0,000 0,33211287 0,34213751 ! regulation of GTPase activity GO:0043087 53 52 0,000 0,33211287 0,34194637 ! sodium ion transport GO:0006814 53 53 0,000 0,33729711 0,34709021 ! tRNA metabolic process GO:0006399 53 53 0,000 0,33729711 0,34689652 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 53 53 0,000 0,33729711 0,34670305 ! carbohydrate biosynthetic process GO:0016051 53 53 0,000 0,33729711 0,3465098 ! hormone metabolic process GO:0042445 55 54 0,000 0,34244187 0,35159909 ! nucleosome organization GO:0034728 55 55 0,000 0,34754743 0,35664249 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 55 55 0,000 0,34754743 0,35644403 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! in utero embryonic development GO:0001701 55 55 0,000 0,34754743 0,35624578 ! ribonucleoside triphosphate biosynthetic process GO:0009201 56 56 0,000 0,35261409 0,36123834 ! ATP metabolic process GO:0046034 57 57 0,000 0,35764215 0,36618582 ! nucleoside triphosphate biosynthetic process GO:0009142 57 57 0,000 0,35764215 0,3659825 ! innate immune response GO:0045087 58 58 0,000 0,36263189 0,37088267 ! carboxylic acid transport GO:0046942 59 59 0,000 0,36758359 0,37573852 GO:0015849|organic acid transport, ! protein localization in organelle GO:0033365 59 59 0,000 0,36758359 0,37553024 ! potassium ion transport GO:0006813 60 60 0,000 0,37249754 0,38033959 ! negative regulation of cellular protein metabolic process GO:0032269 60 60 0,000 0,37249754 0,380129 ! lipid transport GO:0006869 62 62 0,000 0,38221332 0,38982798 ! purine ribonucleoside triphosphate metabolic process GO:0009205 62 62 0,000 0,38221332 0,38961237 ! regulation of cellular component biogenesis GO:0044087 63 62 0,000 0,38221332 0,38939699 ! protein import GO:0017038 62 62 0,000 0,38221332 0,38918185 ! di-, tri-valent inorganic cation transport GO:0015674 63 62 0,000 0,38221332 0,38896696 ! ribonucleoside triphosphate metabolic process GO:0009199 63 63 0,000 0,38701571 0,39363684 ! purine nucleoside triphosphate metabolic process GO:0009144 63 63 0,000 0,38701571 0,39341973 ! angiogenesis GO:0001525 65 64 0,000 0,39178147 0,39804479 ! anion transport GO:0006820 65 65 0,000 0,39651087 0,40262784 ! protein amino acid glycosylation GO:0006486 66 66 0,000 0,40120418 0,40716922 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! nucleoside triphosphate metabolic process GO:0009141 66 66 0,000 0,40120418 0,40694513 ! polysaccharide metabolic process GO:0005976 69 66 0,000 0,40120418 0,40672129 ! Golgi vesicle transport GO:0048193 67 67 0,000 0,40586168 0,41121664 ! muscle contraction GO:0006936 67 67 0,000 0,40586168 0,4109907 ! negative regulation of cell differentiation GO:0045596 68 67 0,000 0,40586168 0,410765 ! purine ribonucleotide biosynthetic process GO:0009152 68 68 0,000 0,41048363 0,41521478 ! chromatin assembly or disassembly GO:0006333 68 68 0,000 0,41048363 0,41498701 ! regionalization GO:0003002 70 69 0,000 0,41507029 0,41939394 ! translational elongation GO:0006414 71 71 0,000 0,42413883 0,42832212 ! oxidative phosphorylation GO:0006119 71 71 0,000 0,42413883 0,42808755 ! ribosome biogenesis GO:0042254 71 71 0,000 0,42413883 0,42785324 ! negative regulation of signal transduction GO:0009968 71 71 0,000 0,42413883 0,42761918 ! muscle system process GO:0003012 72 72 0,000 0,42862123 0,43190209 ! positive regulation of hydrolase activity GO:0051345 72 72 0,000 0,42862123 0,43166608 ! ribonucleotide biosynthetic process GO:0009260 75 75 0,000 0,44186402 0,44475991 ! purine ribonucleotide metabolic process GO:0009150 75 75 0,000 0,44186402 0,44451714 ! negative regulation of cell communication GO:0010648 76 76 0,000 0,44621101 0,44864533 ! nuclear transport GO:0051169 79 79 0,000 0,45905361 0,46130633 GO:0006913|nucleocytoplasmic transport, ! glycoprotein biosynthetic process GO:0009101 80 80 0,000 0,46326919 0,46528889 ! lipid catabolic process GO:0016042 82 81 0,000 0,46745253 0,46923476 ! ribonucleotide metabolic process GO:0009259 83 83 0,000 0,47572347 0,47727728 ! ncRNA processing GO:0034470 83 83 0,000 0,47572347 0,47701761 ! blood vessel morphogenesis GO:0048514 84 83 0,000 0,47572347 0,47675822 ! purine nucleotide biosynthetic process GO:0006164 88 88 0,000 0,49585339 0,49666185 ! visual perception GO:0007601 93 92 0,000 0,51140958 0,51196516 GO:0050953|sensory perception of light stimulus, ! pattern specification process GO:0007389 96 94 0,000 0,51901008 0,51929185 ! regulation of system process GO:0044057 98 98 0,000 0,53386471 0,53386471