pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6240-Schmidt-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 3,000 1,717E-08 3,949E-05 GO:0016446|somatic hypermutation of immunoglobulin genes, ! mismatch repair GO:0006298 34 29 4,000 2,463E-07 2,832E-04 ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 3,000 8,638E-07 6,622E-04 ! nuclear migration GO:0007097 10 5 2,000 1,063E-06 6,111E-04 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 1,063E-06 4,889E-04 GO:0031272|regulation of pseudopodium assembly, ! determination of adult lifespan GO:0008340 8 5 2,000 1,063E-06 4,074E-04 ! somatic diversification of immunoglobulins GO:0016445 29 19 3,000 1,819E-06 5,978E-04 ! regulation of helicase activity GO:0051095 11 6 2,000 2,118E-06 6,09E-04 ! male meiosis GO:0007140 7 6 2,000 2,118E-06 5,413E-04 ! regulation of protein export from nucleus GO:0046825 6 6 2,000 2,118E-06 4,872E-04 ! negative regulation of DNA recombination GO:0045910 9 6 2,000 2,118E-06 4,429E-04 ! macrophage differentiation GO:0030225 10 6 2,000 2,118E-06 4,06E-04 ! response to UV GO:0009411 75 46 4,000 2,666E-06 4,717E-04 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 3,000 2,789E-06 4,582E-04 GO:0016444|somatic cell DNA recombination, ! immunoglobulin production GO:0002377 33 21 3,000 2,789E-06 4,276E-04 GO:0002440|production of molecular mediator of immune response, ! regulation of DNA metabolic process GO:0051052 135 85 5,000 3,317E-06 4,768E-04 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 3,694E-06 4,998E-04 ! multicellular organismal aging GO:0010259 11 7 2,000 3,694E-06 4,72E-04 ! establishment of nucleus localization GO:0040023 13 7 2,000 3,694E-06 4,472E-04 ! somatic diversification of immune receptors GO:0002200 35 23 3,000 4,096E-06 4,711E-04 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 4,898E-06 5,364E-04 ! DNA recombination GO:0006310 146 92 5,000 5,265E-06 5,504E-04 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 5,89E-06 5,89E-04 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 5,89E-06 5,644E-04 ! nucleus localization GO:0051647 15 9 2,000 8,804E-06 8,1E-04 ! positive regulation of catabolic process GO:0009896 40 28 3,000 9,3E-06 8,227E-04 ! regulation of cell projection assembly GO:0060491 20 10 2,000 1,253E-05 1,068E-03 ! response to X-ray GO:0010165 16 10 2,000 1,253E-05 1,03E-03 ! negative regulation of DNA metabolic process GO:0051053 48 32 3,000 1,61E-05 1,277E-03 ! filopodium assembly GO:0046847 19 11 2,000 1,717E-05 1,317E-03 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 2,000 1,717E-05 1,274E-03 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! cellular response to insulin stimulus GO:0032869 52 34 3,000 2,061E-05 1,481E-03 ! regulation of catabolic process GO:0009894 106 70 4,000 2,151E-05 1,499E-03 ! positive regulation of cellular catabolic process GO:0031331 22 12 2,000 2,282E-05 1,544E-03 ! immunoglobulin production during immune response GO:0002381 20 12 2,000 2,282E-05 1,5E-03 ! microspike assembly GO:0030035 23 12 2,000 2,282E-05 1,458E-03 ! regulation of intracellular protein transport GO:0033157 59 35 3,000 2,318E-05 1,441E-03 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 2,82E-05 1,707E-03 ! regulation of protein transport GO:0051223 114 76 4,000 3,21E-05 1,893E-03 GO:0070201|regulation of establishment of protein localization, ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 3,973E-05 2,284E-03 ! regulation of survival gene product expression GO:0045884 20 15 2,000 4,67E-05 2,62E-03 ! peptidyl-serine phosphorylation GO:0018105 23 15 2,000 4,67E-05 2,558E-03 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 3,000 4,83E-05 2,584E-03 ! response to insulin stimulus GO:0032868 63 43 3,000 5,306E-05 2,774E-03 ! regulation of protein localization GO:0032880 132 85 4,000 5,51E-05 2,816E-03 ! positive regulation of cell cycle GO:0045787 77 45 3,000 6,36E-05 3,18E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 6,36E-05 3,112E-03 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 2,000 6,932E-05 3,321E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 2,000 6,932E-05 3,254E-03 ! peptidyl-serine modification GO:0018209 27 17 2,000 6,932E-05 3,189E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 8,289E-05 3,738E-03 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 8,471E-05 3,747E-03 ! regulation of intracellular transport GO:0032386 78 49 3,000 8,912E-05 3,868E-03 ! germ cell development GO:0007281 68 49 3,000 8,912E-05 3,796E-03 ! positive regulation of protein catabolic process GO:0045732 23 19 2,000 9,809E-05 4,102E-03 ! positive regulation of intracellular transport GO:0032388 29 19 2,000 9,809E-05 4,029E-03 ! response to light stimulus GO:0009416 153 96 4,000 9,852E-05 3,975E-03 ! regulation of protein catabolic process GO:0042176 77 51 3,000 1,044E-04 4,138E-03 ! aging GO:0007568 79 52 3,000 1,126E-04 4,391E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 2,000 1,15E-04 4,408E-03 ! cell projection assembly GO:0030031 76 53 3,000 1,214E-04 4,577E-03 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 1,337E-04 4,96E-03 ! regulation of DNA recombination GO:0000018 40 21 2,000 1,337E-04 4,881E-03 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 1,337E-04 4,805E-03 ! DNA damage response, signal transduction GO:0042770 96 56 3,000 1,506E-04 5,329E-03 ! blastocyst development GO:0001824 37 22 2,000 1,543E-04 5,376E-03 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 1,614E-04 5,54E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 1,768E-04 5,98E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 2,014E-04 6,712E-03 ! regulation of cellular catabolic process GO:0031329 36 24 2,000 2,014E-04 6,616E-03 ! meiosis GO:0007126 96 61 3,000 2,101E-04 6,807E-03 GO:0051327|M phase of meiotic cell cycle, ! meiotic cell cycle GO:0051321 97 62 3,000 2,238E-04 7,149E-03 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 1,000 2,26E-04 7,121E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 2,26E-04 7,025E-03 ! anagen GO:0042640 6 5 1,000 2,26E-04 6,931E-03 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 2,26E-04 6,84E-03 ! microvillus organization GO:0032528 7 5 1,000 2,26E-04 6,751E-03 GO:0030033|microvillus assembly, ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 1,000 2,26E-04 6,664E-03 ! early endosome to late endosome transport GO:0045022 11 5 1,000 2,26E-04 6,58E-03 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 1,000 2,26E-04 6,498E-03 ! centrosome duplication GO:0051298 5 5 1,000 2,26E-04 6,417E-03 ! response to food GO:0032094 5 5 1,000 2,26E-04 6,339E-03 ! response to UV-C GO:0010225 6 5 1,000 2,26E-04 6,263E-03 ! regulation of respiratory burst GO:0060263 8 5 1,000 2,26E-04 6,188E-03 ! response to ionizing radiation GO:0010212 47 27 2,000 2,88E-04 7,793E-03 ! negative regulation of protein transport GO:0051224 49 27 2,000 2,88E-04 7,702E-03 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 3,214E-04 8,498E-03 ! placenta development GO:0001890 37 28 2,000 3,214E-04 8,401E-03 ! cytokinesis during cell cycle GO:0033205 9 6 1,000 3,38E-04 8,734E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 3,38E-04 8,637E-03 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 1,000 3,38E-04 8,542E-03 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! ER overload response GO:0006983 7 6 1,000 3,38E-04 8,449E-03 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 1,000 3,38E-04 8,358E-03 ! male sex determination GO:0030238 9 6 1,000 3,38E-04 8,269E-03 ! negative regulation of translational initiation GO:0045947 7 6 1,000 3,38E-04 8,182E-03 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 1,000 3,38E-04 8,097E-03 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! hair follicle maturation GO:0048820 7 6 1,000 3,38E-04 8,013E-03 ! blastocyst growth GO:0001832 15 6 1,000 3,38E-04 7,931E-03 ! negative regulation of transport GO:0051051 116 73 3,000 4,195E-04 9,746E-03 ! mitochondrion organization GO:0007005 104 73 3,000 4,195E-04 9,648E-03 ! mammary gland development GO:0030879 57 31 2,000 4,365E-04 9,94E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 1,000 4,717E-04 0,01063531 ! synaptonemal complex assembly GO:0007130 10 7 1,000 4,717E-04 0,01053205 GO:0070193|synaptonemal complex organization, ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 4,717E-04 0,01043078 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 4,717E-04 0,01033144 GO:0021940|positive regulation of granule cell precursor proliferation, ! positive regulation of mitotic cell cycle GO:0045931 11 7 1,000 4,717E-04 0,01023397 ! protein heterooligomerization GO:0051291 10 7 1,000 4,717E-04 0,01013833 ! response to UV-B GO:0010224 11 7 1,000 4,717E-04 0,01004446 ! fibrinolysis GO:0042730 9 7 1,000 4,717E-04 9,952E-03 ! positive regulation of monooxygenase activity GO:0032770 11 7 1,000 4,717E-04 9,862E-03 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 4,717E-04 9,773E-03 ! meiosis I GO:0007127 52 32 2,000 4,8E-04 9,857E-03 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 5,261E-04 0,01070924 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 5,751E-04 0,01160236 ! glycogen metabolic process GO:0005977 48 35 2,000 6,268E-04 0,01253626 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 6,269E-04 0,01243005 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 6,269E-04 0,01232381 ! middle ear morphogenesis GO:0042474 9 8 1,000 6,269E-04 0,01221938 ! multicellular organism growth GO:0035264 14 8 1,000 6,269E-04 0,01211669 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 6,269E-04 0,01201572 ! regulation of telomere maintenance GO:0032204 10 8 1,000 6,269E-04 0,01191642 ! regulation of embryonic development GO:0045995 16 8 1,000 6,269E-04 0,01181874 ! glucan metabolic process GO:0044042 49 36 2,000 6,814E-04 0,01274226 GO:0006073|cellular glucan metabolic process, ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 7,47E-04 0,01385619 ! cell cycle arrest GO:0007050 150 86 3,000 7,806E-04 0,01436354 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 8,035E-04 0,01466721 ! regulation of developmental growth GO:0048638 13 9 1,000 8,035E-04 0,01455172 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 8,035E-04 0,01443803 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 8,035E-04 0,01432611 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 15 9 1,000 8,035E-04 0,01421591 ! receptor clustering GO:0043113 15 9 1,000 8,035E-04 0,01410739 ! motor axon guidance GO:0008045 14 9 1,000 8,035E-04 0,01400052 ! postreplication repair GO:0006301 11 9 1,000 8,035E-04 0,01389525 ! oocyte differentiation GO:0009994 12 9 1,000 8,035E-04 0,01379155 GO:0048599|oocyte development, ! blastocyst formation GO:0001825 12 9 1,000 8,035E-04 0,01368939 ! embryonic placenta development GO:0001892 12 9 1,000 8,035E-04 0,01358874 ! regulation of epithelial cell proliferation GO:0050678 71 39 2,000 8,632E-04 0,01449188 ! developmental growth GO:0048589 62 39 2,000 8,632E-04 0,01438687 ! reproductive developmental process GO:0003006 127 89 3,000 8,878E-04 0,01469052 ! leukocyte differentiation GO:0002521 143 90 3,000 9,257E-04 0,01520863 ! double-strand break repair GO:0006302 67 40 2,000 9,3E-04 0,01516991 ! positive regulation of protein transport GO:0051222 55 40 2,000 9,3E-04 0,01506308 ! energy reserve metabolic process GO:0006112 59 41 2,000 9,999E-04 0,01608292 ! synapsis GO:0007129 13 10 1,000 1,001E-03 0,01599221 GO:0070192|chromosome organization involved in meiosis, ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 1,000 1,001E-03 0,01588192 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 1,000 1,001E-03 0,01577314 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 1,001E-03 0,01566584 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 1,000 1,001E-03 0,01555999 ! glucan biosynthetic process GO:0009250 13 10 1,000 1,001E-03 0,01545556 GO:0005978|glycogen biosynthetic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 1,001E-03 0,01535252 ! DNA methylation GO:0006306 15 10 1,000 1,001E-03 0,01525085 GO:0006305|DNA alkylation, ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 1,001E-03 0,01515052 GO:0043470|regulation of carbohydrate catabolic process, ! cytoplasmic sequestering of protein GO:0051220 14 10 1,000 1,001E-03 0,01505149 ! in utero embryonic development GO:0001701 147 96 3,000 1,178E-03 0,01758752 ! virus-host interaction GO:0019048 17 11 1,000 1,22E-03 0,01810227 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 1,000 1,22E-03 0,01798623 ! double-strand break repair via homologous recombination GO:0000724 16 11 1,000 1,22E-03 0,01787167 GO:0000725|recombinational repair, ! detection of mechanical stimulus GO:0050982 15 11 1,000 1,22E-03 0,01775855 ! dopamine receptor signaling pathway GO:0007212 22 11 1,000 1,22E-03 0,01764686 ! regulation of mRNA processing GO:0050684 18 11 1,000 1,22E-03 0,01753657 ! plasma membrane organization GO:0007009 18 11 1,000 1,22E-03 0,01742765 ! actin cytoskeleton reorganization GO:0031532 21 11 1,000 1,22E-03 0,01732007 ! T cell homeostasis GO:0043029 20 11 1,000 1,22E-03 0,01721381 ! protein-chromophore linkage GO:0018298 13 11 1,000 1,22E-03 0,01710885 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 1,22E-03 0,01700516 GO:0042130|negative regulation of T cell proliferation, ! regulation of cell projection organization GO:0031344 83 44 2,000 1,23E-03 0,01703541 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 1,459E-03 0,02009895 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 1,459E-03 0,01997932 ! peptidyl-lysine modification GO:0018205 18 12 1,000 1,459E-03 0,01986109 ! response to gamma radiation GO:0010332 20 12 1,000 1,459E-03 0,01974427 ! response to estrogen stimulus GO:0043627 74 47 2,000 1,49E-03 0,02003838 ! immunoglobulin mediated immune response GO:0016064 66 48 2,000 1,584E-03 0,02117677 GO:0019724|B cell mediated immunity, ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 1,584E-03 0,02105436 ! regulation of DNA replication GO:0006275 75 48 2,000 1,584E-03 0,02093336 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 1,719E-03 0,0225968 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 1,719E-03 0,02246841 ! positive regulation of protein import into nucleus GO:0042307 23 13 1,000 1,719E-03 0,02234147 ! regulation of monooxygenase activity GO:0032768 26 13 1,000 1,719E-03 0,02221596 ! lymphocyte homeostasis GO:0002260 24 13 1,000 1,719E-03 0,02209184 ! positive regulation of growth GO:0045927 67 50 2,000 1,782E-03 0,02277343 ! establishment of organelle localization GO:0051656 85 52 2,000 1,996E-03 0,02536075 ! regulation of S phase GO:0033261 18 14 1,000 2E-03 0,02527001 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 2E-03 0,02513192 ! activation of MAPKK activity GO:0000186 21 14 1,000 2E-03 0,02499533 ! negative regulation of blood coagulation GO:0030195 19 14 1,000 2E-03 0,02486022 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 2E-03 0,02472656 ! regulation of protein complex assembly GO:0043254 81 54 2,000 2,225E-03 0,02736108 ! lipid phosphorylation GO:0046834 23 15 1,000 2,3E-03 0,02813923 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 2,3E-03 0,02799034 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 2,3E-03 0,02784303 ! centrosome cycle GO:0007098 16 15 1,000 2,3E-03 0,02769725 ! positive regulation of proteolysis GO:0045862 19 15 1,000 2,3E-03 0,02755299 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 2,3E-03 0,02741023 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 2,3E-03 0,02726894 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 2,3E-03 0,0271291 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! regulation of lipid metabolic process GO:0019216 84 56 2,000 2,469E-03 0,02897318 ! developmental maturation GO:0021700 75 57 2,000 2,597E-03 0,03032288 ! gonad development GO:0008406 79 57 2,000 2,597E-03 0,03016974 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 2,62E-03 0,0302869 ! protein amino acid acetylation GO:0006473 28 16 1,000 2,62E-03 0,03013546 ! oogenesis GO:0048477 23 16 1,000 2,62E-03 0,02998554 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 2,62E-03 0,02983709 ! negative regulation of translation GO:0017148 22 16 1,000 2,62E-03 0,02969011 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 2,729E-03 0,0307734 ! activation of MAPK activity GO:0000187 84 59 2,000 2,866E-03 0,03215288 ! myeloid cell differentiation GO:0030099 85 59 2,000 2,866E-03 0,0319968 ! signal complex assembly GO:0007172 29 17 1,000 2,961E-03 0,03289588 ! neuromuscular junction development GO:0007528 23 17 1,000 2,961E-03 0,03273773 ! negative regulation of protein catabolic process GO:0042177 26 17 1,000 2,961E-03 0,03258109 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 2,961E-03 0,03242594 ! negative regulation of coagulation GO:0050819 23 17 1,000 2,961E-03 0,03227226 ! cell-matrix adhesion GO:0007160 114 61 2,000 3,151E-03 0,03418417 ! lymphocyte mediated immunity GO:0002449 88 62 2,000 3,3E-03 0,03563083 ! organelle localization GO:0051640 96 62 2,000 3,3E-03 0,03546433 ! positive regulation of DNA replication GO:0045740 29 18 1,000 3,32E-03 0,03551999 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 1,000 3,32E-03 0,03535554 ! somitogenesis GO:0001756 24 18 1,000 3,32E-03 0,03519261 ! negative regulation of T cell activation GO:0050868 25 18 1,000 3,32E-03 0,03503118 ! regulation of transcription factor activity GO:0051090 97 63 2,000 3,453E-03 0,03626235 GO:0090046|regulation of transcription regulator activity, ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 3,453E-03 0,03609752 ! adaptive immune response GO:0002250 94 64 2,000 3,61E-03 0,03757192 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reciprocal meiotic recombination GO:0007131 31 19 1,000 3,699E-03 0,03832748 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 1,000 3,699E-03 0,03815561 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 3,699E-03 0,03798527 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 3,699E-03 0,03781645 ! response to alkaloid GO:0043279 32 19 1,000 3,699E-03 0,03764912 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 1,000 3,699E-03 0,03748327 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 3,699E-03 0,03731887 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 3,699E-03 0,0371559 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 3,699E-03 0,03699435 ! apoptotic nuclear changes GO:0030262 24 19 1,000 3,699E-03 0,03683421 ! sex determination GO:0007530 29 19 1,000 3,699E-03 0,03667544 ! protein stabilization GO:0050821 26 19 1,000 3,699E-03 0,03651803 ! reproductive structure development GO:0048608 90 65 2,000 3,772E-03 0,03707382 ! B cell activation GO:0042113 104 65 2,000 3,772E-03 0,03691606 ! cell-substrate adhesion GO:0031589 121 66 2,000 3,938E-03 0,03837786 ! DNA modification GO:0006304 28 20 1,000 4,098E-03 0,03976676 ! development of primary sexual characteristics GO:0045137 92 68 2,000 4,283E-03 0,04139228 ! response to drug GO:0042493 108 69 2,000 4,463E-03 0,0429448 ! gluconeogenesis GO:0006094 25 21 1,000 4,515E-03 0,04326845 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 4,515E-03 0,04308891 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 4,515E-03 0,04291086 ! protein amino acid acylation GO:0043543 37 21 1,000 4,515E-03 0,04273427 ! cell aging GO:0007569 32 21 1,000 4,515E-03 0,04255913 ! response to endoplasmic reticulum stress GO:0034976 25 21 1,000 4,515E-03 0,04238542 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 4,835E-03 0,04520236 ! leukocyte mediated immunity GO:0002443 99 71 2,000 4,835E-03 0,04501935 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 4,951E-03 0,04591688 ! molting cycle process GO:0022404 40 22 1,000 4,951E-03 0,04573248 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 1,000 4,951E-03 0,04554955 ! vasculogenesis GO:0001570 33 22 1,000 4,951E-03 0,04536807 ! microtubule organizing center organization GO:0031023 28 22 1,000 4,951E-03 0,04518804 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 4,951E-03 0,04500943 ! leukocyte homeostasis GO:0001776 33 22 1,000 4,951E-03 0,04483223 ! regulation of blood coagulation GO:0030193 34 22 1,000 4,951E-03 0,04465642 ! protein tetramerization GO:0051262 39 22 1,000 4,951E-03 0,04448198 ! response to hypoxia GO:0001666 132 72 2,000 5,028E-03 0,04499399 ! response to steroid hormone stimulus GO:0048545 114 73 2,000 5,225E-03 0,04658016 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 5,406E-03 0,04800452 ! myelination GO:0042552 35 23 1,000 5,406E-03 0,04781988 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 5,406E-03 0,04763667 ! regulation of transcription factor import into nucleus GO:0042990 46 23 1,000 5,406E-03 0,04745485 ! ER-nuclear signaling pathway GO:0006984 27 23 1,000 5,406E-03 0,04727441 ! negative regulation of DNA replication GO:0008156 35 23 1,000 5,406E-03 0,04709534 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 5,406E-03 0,04691762 ! interaction with host GO:0051701 37 23 1,000 5,406E-03 0,04674124 ! cellular response to oxidative stress GO:0034599 33 23 1,000 5,406E-03 0,04656618 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 5,406E-03 0,04639242 ! negative regulation of catabolic process GO:0009895 34 23 1,000 5,406E-03 0,04621996 ! response to oxygen levels GO:0070482 137 74 2,000 5,427E-03 0,0462316 ! blood coagulation GO:0007596 116 75 2,000 5,634E-03 0,04781575 GO:0050817|coagulation, ! pyruvate metabolic process GO:0006090 29 24 1,000 5,879E-03 0,04971086 ! receptor metabolic process GO:0043112 37 24 1,000 5,879E-03 0,04952877 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 5,879E-03 0,04934801 ! regulation of DNA binding GO:0051101 119 77 2,000 6,062E-03 0,05069628 ! gland development GO:0048732 148 77 2,000 6,062E-03 0,05051259 ! sex differentiation GO:0007548 105 77 2,000 6,062E-03 0,05033024 ! protein ubiquitination GO:0016567 125 77 2,000 6,062E-03 0,05014919 ! carbohydrate biosynthetic process GO:0016051 97 77 2,000 6,062E-03 0,04996945 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 6,37E-03 0,05232685 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 6,37E-03 0,05214063 GO:0045936|negative regulation of phosphate metabolic process, ! male gonad development GO:0008584 33 25 1,000 6,37E-03 0,05195573 ! iron ion homeostasis GO:0055072 39 25 1,000 6,37E-03 0,05177214 ! regulation of chromosome organization GO:0033044 35 25 1,000 6,37E-03 0,05158985 ! response to estradiol stimulus GO:0032355 34 25 1,000 6,37E-03 0,05140883 ! positive regulation of nuclear division GO:0051785 39 25 1,000 6,37E-03 0,05122908 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 6,37E-03 0,05105058 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 6,37E-03 0,05087332 ! oxidative phosphorylation GO:0006119 105 79 2,000 6,508E-03 0,05179379 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 6,88E-03 0,0545629 ! negative regulation of protein modification process GO:0031400 50 26 1,000 6,88E-03 0,0543754 ! regulation of coagulation GO:0050818 39 26 1,000 6,88E-03 0,05418918 ! hemostasis GO:0007599 125 81 2,000 6,974E-03 0,05474176 ! regulation of cell cycle process GO:0010564 122 81 2,000 6,974E-03 0,05455557 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 7,407E-03 0,05774952 ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 7,407E-03 0,05755442 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 7,407E-03 0,05736063 ! response to organic cyclic substance GO:0014070 47 28 1,000 7,952E-03 0,06137486 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 7,952E-03 0,06116959 ! ensheathment of neurons GO:0007272 43 28 1,000 7,952E-03 0,06096569 GO:0008366|axon ensheathment, ! cellular defense response GO:0006968 102 87 2,000 8,487E-03 0,06485231 ! skeletal muscle tissue development GO:0007519 123 87 2,000 8,487E-03 0,06463757 GO:0060538|skeletal muscle organ development, ! regulation of protein import into nucleus GO:0042306 53 29 1,000 8,515E-03 0,06463244 ! hexose biosynthetic process GO:0019319 35 29 1,000 8,515E-03 0,06441983 ! tissue homeostasis GO:0001894 42 29 1,000 8,515E-03 0,06420862 GO:0048871|multicellular organismal homeostasis, ! negative regulation of cell activation GO:0050866 44 30 1,000 9,095E-03 0,06835773 ! response to heat GO:0009408 41 30 1,000 9,095E-03 0,06813507 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 9,311E-03 0,06952796 ! DNA damage checkpoint GO:0000077 53 31 1,000 9,692E-03 0,07213856 ! negative regulation of secretion GO:0051048 49 31 1,000 9,692E-03 0,07190585 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 1,000 9,692E-03 0,07167464 ! maintenance of protein location in cell GO:0032507 60 31 1,000 9,692E-03 0,07144492 ! segmentation GO:0035282 41 31 1,000 9,692E-03 0,07121666 ! response to mechanical stimulus GO:0009612 43 31 1,000 9,692E-03 0,07098985 ! polysaccharide metabolic process GO:0005976 129 93 2,000 0,01017939 0,07432572 ! regulation of synaptic plasticity GO:0048167 52 32 1,000 0,01030577 0,07501035 ! peripheral nervous system development GO:0007422 53 32 1,000 0,01030577 0,07477373 ! regulation of protein stability GO:0031647 48 32 1,000 0,01030577 0,07453859 ! monosaccharide biosynthetic process GO:0046364 38 32 1,000 0,01030577 0,07430493 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,01030577 0,07407272 ! response to oxidative stress GO:0006979 141 94 2,000 0,01047908 0,07508375 ! regulation of binding GO:0051098 151 95 2,000 0,01078385 0,07702753 ! angiogenesis GO:0001525 149 95 2,000 0,01078385 0,07678906 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 1,000 0,01093671 0,07763716 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 0,01093671 0,07739828 ! ear morphogenesis GO:0042471 42 33 1,000 0,01093671 0,07716086 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,01093671 0,0769249 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 1,000 0,01093671 0,07669037 ! female gonad development GO:0008585 49 33 1,000 0,01093671 0,07645727 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,01093671 0,07622558 ! regulation of proteolysis GO:0030162 50 33 1,000 0,01093671 0,07599529 ! cytokinesis GO:0000910 52 33 1,000 0,01093671 0,07576639 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,01109373 0,07662339 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 0,01109373 0,07639398 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,01158432 0,07953411 ! DNA integrity checkpoint GO:0031570 57 34 1,000 0,01158432 0,0792974 ! female gamete generation GO:0007292 43 34 1,000 0,01158432 0,0790621 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 0,01205414 0,08202522 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 0,01224841 0,08310129 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,01224841 0,08285687 ! maintenance of protein location GO:0045185 65 35 1,000 0,01224841 0,08261389 ! regulation of translation GO:0006417 151 100 2,000 0,01238458 0,0832881 ! regulation of body fluid levels GO:0050878 154 100 2,000 0,01238458 0,08304528 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 0,01292882 0,08644267 GO:0090047|positive regulation of transcription regulator activity, ! response to reactive oxygen species GO:0000302 55 36 1,000 0,01292882 0,08619211 ! negative regulation of binding GO:0051100 58 36 1,000 0,01292882 0,085943 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,01292882 0,08569533 GO:0046660|female sex differentiation, ! learning GO:0007612 67 37 1,000 0,01362538 0,09005279 ! regulation of protein secretion GO:0050708 51 37 1,000 0,01362538 0,08979476 ! amino acid activation GO:0043038 52 37 1,000 0,01362538 0,0895382 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,01433792 0,0939522 ! pigmentation GO:0043473 74 38 1,000 0,01433792 0,09368529 ! maintenance of location in cell GO:0051651 69 38 1,000 0,01433792 0,09341989 ! alcohol biosynthetic process GO:0046165 45 38 1,000 0,01433792 0,093156 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,01506629 0,09761256 ! male sex differentiation GO:0046661 53 39 1,000 0,01506629 0,09733836 ! synapse organization GO:0050808 55 39 1,000 0,01506629 0,09706571 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,0158103 0,10157456 ! ATP synthesis coupled electron transport GO:0042773 48 40 1,000 0,0158103 0,10129163 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! B cell differentiation GO:0030183 62 40 1,000 0,0158103 0,10101026 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,0158103 0,10073045 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,01656981 0,10527778 ! glucose transport GO:0015758 52 41 1,000 0,01656981 0,10498776 ! endosome transport GO:0016197 71 41 1,000 0,01656981 0,10469933 ! positive regulation of DNA binding GO:0043388 57 41 1,000 0,01656981 0,10441249 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,01656981 0,10412721 ! biopolymer methylation GO:0043414 62 41 1,000 0,01656981 0,10384348 ! cellular component disassembly GO:0022411 64 42 1,000 0,01734464 0,10840401 ! hexose transport GO:0008645 54 42 1,000 0,01734464 0,10811023 GO:0015749|monosaccharide transport, ! branching morphogenesis of a tube GO:0048754 72 42 1,000 0,01734464 0,10781804 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,01734464 0,10752742 ! positive regulation of binding GO:0051099 59 43 1,000 0,01813464 0,11212278 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 0,01813464 0,11182218 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,01813464 0,11152319 ! activation of caspase activity GO:0006919 65 43 1,000 0,01813464 0,1112258 ! DNA-dependent DNA replication GO:0006261 59 43 1,000 0,01813464 0,11092998 ! methylation GO:0032259 64 43 1,000 0,01813464 0,11063574 ! regulation of action potential GO:0001508 71 44 1,000 0,01893965 0,11524124 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,01893965 0,11493717 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,01893965 0,1146347 ! regulation of translational initiation GO:0006446 64 45 1,000 0,0197595 0,11928307 ! cell maturation GO:0048469 60 45 1,000 0,0197595 0,11897081 ! histone modification GO:0016570 68 46 1,000 0,02059404 0,12367181 ! respiratory electron transport chain GO:0022904 59 47 1,000 0,02144312 0,12843536 ! covalent chromatin modification GO:0016569 75 47 1,000 0,02144312 0,12810176 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,02144312 0,12776989 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,02144312 0,12743974 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 77 47 1,000 0,02144312 0,12711129 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,02230658 0,13188978 GO:0010952|positive regulation of peptidase activity, ! response to temperature stimulus GO:0009266 62 48 1,000 0,02230658 0,1315516 ! heart morphogenesis GO:0003007 65 48 1,000 0,02230658 0,13121515 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,02230658 0,13088042 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,02318426 0,13568394 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 0,02318426 0,13533956 ! integrin-mediated signaling pathway GO:0007229 81 49 1,000 0,02318426 0,13499693 ! maintenance of location GO:0051235 84 49 1,000 0,02318426 0,13465603 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,02379764 0,13787046 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,02379764 0,13752405 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,02379764 0,13717938 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,02379764 0,13683643 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,02379764 0,13649519 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,02379764 0,13615565 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,02379764 0,13581779 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,02379764 0,13548161 ! sleep GO:0030431 11 5 0,000 0,02379764 0,13514709 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,02379764 0,13481421 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,02379764 0,13448298 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,02379764 0,13415336 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,02379764 0,13382536 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,02379764 0,13349895 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,02379764 0,13317414 ! tongue development GO:0043586 6 5 0,000 0,02379764 0,1328509 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,02379764 0,13252923 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,02379764 0,13220911 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,02379764 0,13189053 ! cobalt ion transport GO:0006824 9 5 0,000 0,02379764 0,13157349 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,02379764 0,13125796 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,02379764 0,13094395 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,02379764 0,13063143 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,02379764 0,13032041 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,02379764 0,13001086 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,02379764 0,12970278 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,02379764 0,12939615 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,02379764 0,12909097 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,02379764 0,12878723 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,02379764 0,12848491 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,02379764 0,12818401 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,02379764 0,12788451 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,02379764 0,12758641 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,02379764 0,1272897 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,02379764 0,12699436 ! malate metabolic process GO:0006108 7 5 0,000 0,02379764 0,1267004 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,02379764 0,12640779 ! behavioral response to pain GO:0048266 7 5 0,000 0,02379764 0,12611652 ! clathrin coat assembly GO:0048268 11 5 0,000 0,02379764 0,1258266 ! phototransduction, visible light GO:0007603 6 5 0,000 0,02379764 0,12553801 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,02379764 0,12525073 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,02379764 0,12496477 ! mating behavior GO:0007617 6 5 0,000 0,02379764 0,12468012 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,02379764 0,12439675 ! rhythmic behavior GO:0007622 12 5 0,000 0,02379764 0,12411467 ! copulation GO:0007620 7 5 0,000 0,02379764 0,12383387 ! glial cell fate commitment GO:0021781 12 5 0,000 0,02379764 0,12355434 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,02379764 0,12327606 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,02379764 0,12299904 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,02379764 0,12272325 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,02379764 0,12244871 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,02379764 0,12217538 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,02379764 0,12190328 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,02379764 0,12163238 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,02379764 0,12136269 ! response to protozoan GO:0001562 9 5 0,000 0,02379764 0,12109418 ! lymph vessel development GO:0001945 7 5 0,000 0,02379764 0,12082687 ! endochondral ossification GO:0001958 12 5 0,000 0,02379764 0,12056073 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,02379764 0,12029576 ! parathyroid gland development GO:0060017 8 5 0,000 0,02379764 0,12003195 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,02379764 0,1197693 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,02379764 0,1195078 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,02379764 0,11924743 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,02379764 0,1189882 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,02379764 0,11873009 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,02379764 0,1184731 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,02379764 0,11821722 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,02379764 0,11796244 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,02379764 0,11770876 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,02379764 0,11745616 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,02379764 0,11720465 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,02379764 0,11695421 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,02379764 0,11670484 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,02379764 0,11645653 ! ovulation GO:0030728 6 5 0,000 0,02379764 0,11620928 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,02379764 0,11596307 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,02379764 0,11571791 ! response to pH GO:0009268 9 5 0,000 0,02379764 0,11547378 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,02379764 0,11523068 ! proline biosynthetic process GO:0006561 6 5 0,000 0,02379764 0,11498859 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,02379764 0,11474753 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,02379764 0,11450747 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,02379764 0,11426842 ! polyol catabolic process GO:0046174 7 5 0,000 0,02379764 0,11403036 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,02379764 0,11379329 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,02379764 0,1135572 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,02379764 0,11332209 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,02379764 0,11308796 ! nerve growth factor processing GO:0032455 7 5 0,000 0,02379764 0,11285479 ! urea metabolic process GO:0019627 6 5 0,000 0,02379764 0,11262257 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,02379764 0,11239132 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,02379764 0,11216101 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,02379764 0,11193164 ! neutrophil activation GO:0042119 5 5 0,000 0,02379764 0,11170321 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,02379764 0,11147571 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,02379764 0,11124913 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,02379764 0,11102347 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,02379764 0,11079873 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,02379764 0,11057489 ! forebrain neuron development GO:0021884 7 5 0,000 0,02379764 0,11035196 ! melanosome organization GO:0032438 7 5 0,000 0,02379764 0,11012992 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,02379764 0,10990878 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,02379764 0,10968852 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,02379764 0,10946914 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,02379764 0,10925064 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,02379764 0,10903301 ! nucleoside transport GO:0015858 6 5 0,000 0,02379764 0,10881624 ! nucleoside salvage GO:0043174 7 5 0,000 0,02379764 0,10860034 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,02379764 0,10838529 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,02379764 0,10817109 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,02379764 0,10795773 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,02379764 0,10774522 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,02379764 0,10753354 ! depyrimidination GO:0045008 8 5 0,000 0,02379764 0,10732269 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,02379764 0,10711266 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,02379764 0,10690346 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,02379764 0,10669507 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,02379764 0,10648749 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,02379764 0,10628072 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,02379764 0,10607475 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,02379764 0,10586958 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,02379764 0,1056652 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,02379764 0,1054616 ! monocyte differentiation GO:0030224 8 5 0,000 0,02379764 0,10525879 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,02379764 0,10505676 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,02379764 0,1048555 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,02379764 0,10465501 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,02379764 0,10445529 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,02379764 0,10425633 ! regulation of dendrite development GO:0050773 12 5 0,000 0,02379764 0,10405812 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,02379764 0,10386067 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,02379764 0,10366396 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,02379764 0,103468 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,02379764 0,10327278 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,02379764 0,10307829 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,02379764 0,10288453 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,02379764 0,1026915 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,02379764 0,1024992 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,02379764 0,10230761 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,02379764 0,10211674 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,02379764 0,10192658 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,02379764 0,10173712 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,02379764 0,10154837 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,02379764 0,10136032 ! neural tube patterning GO:0021532 6 5 0,000 0,02379764 0,10117296 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,02379764 0,10098629 ! histone demethylation GO:0016577 9 5 0,000 0,02379764 0,10080032 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,02379764 0,10061502 ! regulation of sterol transport GO:0032371 7 5 0,000 0,02379764 0,10043041 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,02379764 0,10024647 ! enteric nervous system development GO:0048484 8 5 0,000 0,02379764 0,1000632 ! establishment of planar polarity GO:0001736 6 5 0,000 0,02379764 0,0998806 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,02379764 0,09969867 ! muscle cell proliferation GO:0033002 8 5 0,000 0,02379764 0,0995174 ! transcription termination GO:0006353 8 5 0,000 0,02379764 0,09933679 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,02379764 0,09915683 ! plasminogen activation GO:0031639 5 5 0,000 0,02379764 0,09897752 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,02379764 0,09879886 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,02379764 0,09862085 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,02379764 0,09844347 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,02379764 0,09826673 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,02379764 0,09809063 ! apical protein localization GO:0045176 6 5 0,000 0,02379764 0,09791515 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,02379764 0,09774031 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,02379764 0,09756608 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,02379764 0,09739248 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,02379764 0,09721949 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,02379764 0,09704711 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,02379764 0,09687535 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,02379764 0,09670419 ! glial cell migration GO:0008347 10 5 0,000 0,02379764 0,09653364 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,02379764 0,09636368 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,02379764 0,09619433 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,02379764 0,09602556 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,02379764 0,09585739 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,02379764 0,09568981 ! neural plate development GO:0001840 6 5 0,000 0,02379764 0,09552281 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,02379764 0,0953564 ! regulation of sensory perception GO:0051931 6 5 0,000 0,02379764 0,09519056 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,02379764 0,0950253 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,02379764 0,09486061 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,02379764 0,09469649 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,02379764 0,09453294 ! sensory cilium assembly GO:0035058 6 5 0,000 0,02379764 0,09436995 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,02379764 0,09420752 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,02379764 0,09404565 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,02379764 0,09388434 ! spindle assembly GO:0051225 5 5 0,000 0,02379764 0,09372358 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,02379764 0,09356337 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,02379764 0,09340371 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,02379764 0,09324458 ! organ regeneration GO:0031100 7 5 0,000 0,02379764 0,09308601 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,02379764 0,09292796 ! carnitine metabolic process GO:0009437 5 5 0,000 0,02379764 0,09277046 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,02379764 0,09261349 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,02379764 0,09245705 GO:0055081|anion homeostasis, ! ear development GO:0043583 72 50 1,000 0,024076 0,09338079 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,024076 0,09322359 ! lipid modification GO:0030258 73 50 1,000 0,024076 0,09306691 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,024076 0,09291076 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 0,02498167 0,0962443 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,02498167 0,09608336 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,02498167 0,09592295 ! positive regulation of cell migration GO:0030335 92 51 1,000 0,02498167 0,09576308 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,02498167 0,09560374 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,02590111 0,09895772 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,02590111 0,09879361 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,02683416 0,10218307 ! regulation of mitosis GO:0007088 84 54 1,000 0,02778068 0,10561252 GO:0051783|regulation of nuclear division, ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,02778068 0,10543824 ! DNA catabolic process GO:0006308 67 54 1,000 0,02778068 0,10526454 ! detection of external stimulus GO:0009581 66 54 1,000 0,02778068 0,1050914 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,02778068 0,10491884 ! tRNA transcription GO:0009304 11 6 0,000 0,02848958 0,10741972 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02848958 0,10724391 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02848958 0,10706867 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02848958 0,10689401 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02848958 0,10671992 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02848958 0,10654639 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02848958 0,10637342 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02848958 0,10620102 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02848958 0,10602917 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02848958 0,10585788 ! prostate gland development GO:0030850 9 6 0,000 0,02848958 0,10568714 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02848958 0,10551695 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02848958 0,10534731 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02848958 0,10517822 GO:0021872|generation of neurons in the forebrain, ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02848958 0,10500966 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02848958 0,10484165 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02848958 0,10467417 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02848958 0,10450722 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02848958 0,10434081 ! neuron adhesion GO:0007158 9 6 0,000 0,02848958 0,10417493 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02848958 0,10400957 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02848958 0,10384474 ! signal peptide processing GO:0006465 8 6 0,000 0,02848958 0,10368042 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02848958 0,10351663 ! mRNA stabilization GO:0048255 15 6 0,000 0,02848958 0,10335336 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02848958 0,1031906 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02848958 0,10302835 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02848958 0,10286661 ! opsonization GO:0008228 8 6 0,000 0,02848958 0,10270537 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02848958 0,10254465 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02848958 0,10238442 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02848958 0,10222469 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02848958 0,10206546 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02848958 0,10190673 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02848958 0,10174849 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02848958 0,10159074 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02848958 0,10143348 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02848958 0,10127671 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02848958 0,10112041 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02848958 0,1009646 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02848958 0,10080927 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02848958 0,10065442 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02848958 0,10050004 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02848958 0,10034614 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02848958 0,1001927 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02848958 0,10003974 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02848958 0,09988724 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02848958 0,0997352 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02848958 0,09958363 ! thymic T cell selection GO:0045061 12 6 0,000 0,02848958 0,09943252 ! protein lipoylation GO:0009249 10 6 0,000 0,02848958 0,09928186 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02848958 0,09913166 ! pigment granule organization GO:0048753 11 6 0,000 0,02848958 0,09898192 ! drug transport GO:0015893 6 6 0,000 0,02848958 0,09883262 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02848958 0,09868378 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,02848958 0,09853538 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02848958 0,09838743 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02848958 0,09823992 ! histidine metabolic process GO:0006547 6 6 0,000 0,02848958 0,09809286 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02848958 0,09794623 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02848958 0,09780004 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02848958 0,09765429 ! adenohypophysis development GO:0021984 10 6 0,000 0,02848958 0,09750897 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02848958 0,09736408 ! hyperosmotic response GO:0006972 8 6 0,000 0,02848958 0,09721963 ! microtubule nucleation GO:0007020 10 6 0,000 0,02848958 0,0970756 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02848958 0,09693199 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02848958 0,09678882 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02848958 0,09664606 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02848958 0,09650372 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02848958 0,09636181 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02848958 0,09622031 ! response to dietary excess GO:0002021 7 6 0,000 0,02848958 0,09607922 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02848958 0,09593855 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02848958 0,09579829 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02848958 0,09565844 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02848958 0,09551899 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02848958 0,09537995 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02848958 0,09524132 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02848958 0,09510309 ! neuron apoptosis GO:0051402 8 6 0,000 0,02848958 0,09496526 ! organic alcohol transport GO:0015850 9 6 0,000 0,02848958 0,09482783 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02848958 0,09469079 ! carnitine transport GO:0015879 8 6 0,000 0,02848958 0,09455415 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02848958 0,09441791 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02848958 0,09428206 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02848958 0,09414659 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02848958 0,09401152 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02848958 0,09387683 ! parturition GO:0007567 12 6 0,000 0,02848958 0,09374253 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02848958 0,09360861 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02848958 0,09347508 ! spindle checkpoint GO:0031577 14 6 0,000 0,02848958 0,09334192 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02848958 0,09320914 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02848958 0,09307674 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02848958 0,09294472 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02848958 0,09281307 ! astrocyte development GO:0014002 14 6 0,000 0,02848958 0,09268179 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02848958 0,09255089 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02848958 0,09242035 ! interaction with symbiont GO:0051702 8 6 0,000 0,02848958 0,09229018 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02848958 0,09216038 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02848958 0,09203094 ! eating behavior GO:0042755 6 6 0,000 0,02848958 0,09190186 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02848958 0,09177315 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02848958 0,09164479 ! response to copper ion GO:0046688 9 6 0,000 0,02848958 0,0915168 ! DNA topological change GO:0006265 8 6 0,000 0,02848958 0,09138916 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,02848958 0,09126188 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02848958 0,09113495 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,02848958 0,09100837 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02848958 0,09088215 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02848958 0,09075627 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02848958 0,09063074 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02848958 0,09050556 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02848958 0,09038073 ! gas homeostasis GO:0033483 11 6 0,000 0,02848958 0,09025624 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02848958 0,09013209 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02848958 0,09000828 ! Schwann cell development GO:0014044 14 6 0,000 0,02848958 0,08988481 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02848958 0,08976168 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02848958 0,08963889 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02848958 0,08951643 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02848958 0,08939431 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02848958 0,08927252 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02848958 0,08915106 ! histone ubiquitination GO:0016574 7 6 0,000 0,02848958 0,08902993 ! regulation of meiosis GO:0040020 10 6 0,000 0,02848958 0,08890913 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02848958 0,08878866 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02848958 0,08866851 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02848958 0,08854869 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02848958 0,08842919 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02848958 0,08831001 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02848958 0,08819116 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02848958 0,08807262 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02848958 0,0879544 ! receptor internalization GO:0031623 9 6 0,000 0,02848958 0,0878365 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02848958 0,08771891 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02848958 0,08760164 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02848958 0,08748468 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02848958 0,08736804 ! protein deubiquitination GO:0016579 8 6 0,000 0,02848958 0,0872517 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02848958 0,08713568 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,02848958 0,08701996 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02848958 0,08690455 ! axonal fasciculation GO:0007413 9 6 0,000 0,02848958 0,08678944 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02848958 0,08667464 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02848958 0,08656014 ! midbrain development GO:0030901 6 6 0,000 0,02848958 0,08644595 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02848958 0,08633205 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02848958 0,08621846 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02848958 0,08610516 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02848958 0,08599216 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,02848958 0,08587946 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02848958 0,08576705 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02848958 0,08565494 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02848958 0,08554312 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02848958 0,08543159 ! adult feeding behavior GO:0008343 6 6 0,000 0,02848958 0,08532035 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02848958 0,0852094 ! pigment granule transport GO:0051904 12 6 0,000 0,02848958 0,08509874 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02848958 0,08498836 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02848958 0,08487827 ! catecholamine transport GO:0051937 7 6 0,000 0,02848958 0,08476847 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02848958 0,08465895 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02848958 0,08454971 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02848958 0,08444076 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02848958 0,08433208 ! protein prenylation GO:0018342 10 6 0,000 0,02848958 0,08422369 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02848958 0,08411557 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02848958 0,08400773 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02848958 0,08390016 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02848958 0,08379288 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02848958 0,08368586 ! positive regulation of cell motion GO:0051272 99 56 1,000 0,02971355 0,08716985 ! carbohydrate transport GO:0008643 74 57 1,000 0,0306996 0,08994786 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,0306996 0,08983342 GO:0048609|reproductive process in a multicellular organism, ! viral reproductive process GO:0022415 87 58 1,000 0,03169853 0,09263865 ! lung development GO:0030324 94 59 1,000 0,0327102 0,09547394 ! actin filament organization GO:0007015 95 59 1,000 0,0327102 0,09535294 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,03315923 0,09653954 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,03315923 0,09641749 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,03315923 0,09629575 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,03315923 0,09617432 ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,03315923 0,09605319 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,03315923 0,09593237 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,03315923 0,09581185 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,03315923 0,09569163 ! reproductive behavior GO:0019098 12 7 0,000 0,03315923 0,09557172 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,03315923 0,09545211 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,03315923 0,09533279 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,03315923 0,09521377 ! oligopeptide transport GO:0006857 11 7 0,000 0,03315923 0,09509505 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,03315923 0,09497663 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,03315923 0,0948585 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,03315923 0,09474066 ! RNA methylation GO:0001510 11 7 0,000 0,03315923 0,09462312 ! pericardium development GO:0060039 8 7 0,000 0,03315923 0,09450586 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,03315923 0,0943889 ! fibril organization GO:0043206 13 7 0,000 0,03315923 0,09427223 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,03315923 0,09415584 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,03315923 0,09403974 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,03315923 0,09392393 ! lipoprotein transport GO:0042953 9 7 0,000 0,03315923 0,0938084 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,03315923 0,09369316 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,03315923 0,0935782 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,03315923 0,09346352 ! estrogen metabolic process GO:0008210 14 7 0,000 0,03315923 0,09334912 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,03315923 0,093235 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,03315923 0,09312116 ! chemosensory behavior GO:0007635 9 7 0,000 0,03315923 0,0930076 ! microtubule bundle formation GO:0001578 8 7 0,000 0,03315923 0,09289432 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,03315923 0,09278131 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,03315923 0,09266857 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,03315923 0,09255611 ! leukocyte degranulation GO:0043299 10 7 0,000 0,03315923 0,09244392 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,03315923 0,092332 ! reflex GO:0060004 12 7 0,000 0,03315923 0,09222035 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,03315923 0,09210898 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,03315923 0,09199787 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,03315923 0,09188703 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,03315923 0,09177645 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,03315923 0,09166615 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,03315923 0,0915561 ! spinal cord patterning GO:0021511 7 7 0,000 0,03315923 0,09144632 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,03315923 0,09133681 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,03315923 0,09122755 ! adrenal gland development GO:0030325 17 7 0,000 0,03315923 0,09111856 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,03315923 0,09100982 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,03315923 0,09090135 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,03315923 0,09079313 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,03315923 0,09068518 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,03315923 0,09057747 ! endosome organization GO:0007032 10 7 0,000 0,03315923 0,09047003 ! thyroid hormone generation GO:0006590 11 7 0,000 0,03315923 0,09036284 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,03315923 0,0902559 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,03315923 0,09014921 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,03315923 0,09004278 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,03315923 0,0899366 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,03315923 0,08983066 ! galactose metabolic process GO:0006012 10 7 0,000 0,03315923 0,08972498 ! vesicle fusion GO:0006906 15 7 0,000 0,03315923 0,08961954 ! intracellular pH reduction GO:0051452 10 7 0,000 0,03315923 0,08951436 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,03315923 0,08940942 ! organ growth GO:0035265 11 7 0,000 0,03315923 0,08930472 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,03315923 0,08920027 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,03315923 0,08909607 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,03315923 0,0889921 ! retinol metabolic process GO:0042572 9 7 0,000 0,03315923 0,08888838 ! behavioral fear response GO:0001662 13 7 0,000 0,03315923 0,0887849 GO:0002209|behavioral defense response, ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,03315923 0,08868167 ! rRNA modification GO:0000154 12 7 0,000 0,03315923 0,08857867 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,03315923 0,08847591 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,03315923 0,08837339 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,03315923 0,0882711 ! intermediate filament organization GO:0045109 11 7 0,000 0,03315923 0,08816906 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,03315923 0,08806724 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,03315923 0,08796567 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,03315923 0,08786432 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,03315923 0,08776321 ! B cell lineage commitment GO:0002326 17 7 0,000 0,03315923 0,08766234 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,03315923 0,08756169 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,03315923 0,08746128 ! response to tropane GO:0014073 13 7 0,000 0,03315923 0,08736109 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,03315923 0,08726114 ! melanosome localization GO:0032400 10 7 0,000 0,03315923 0,08716141 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,03315923 0,08706191 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,03315923 0,08696264 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,03315923 0,08686359 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,03315923 0,08676477 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,03315923 0,08666617 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,03315923 0,0865678 ! mast cell activation GO:0045576 9 7 0,000 0,03315923 0,08646965 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,03315923 0,08637172 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,03315923 0,08627402 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,03315923 0,08617653 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,03315923 0,08607927 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,03315923 0,08598222 ! T cell lineage commitment GO:0002360 12 7 0,000 0,03315923 0,0858854 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,03315923 0,08578879 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,03315923 0,0856924 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,03315923 0,08559622 ! regulation of lipid transport GO:0032368 13 7 0,000 0,03315923 0,08550026 ! response to tumor cell GO:0002347 12 7 0,000 0,03315923 0,08540452 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,03315923 0,08530899 ! neuroblast proliferation GO:0007405 13 7 0,000 0,03315923 0,08521367 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,03315923 0,08511856 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,03315923 0,08502367 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,03315923 0,08492899 ! diuresis GO:0030146 12 7 0,000 0,03315923 0,08483452 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,03315923 0,08474026 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,03315923 0,08464621 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,03315923 0,08455236 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,03315923 0,08445873 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,03315923 0,0843653 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,03315923 0,08427208 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,03315923 0,08417906 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,03315923 0,08408625 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,03315923 0,08399365 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,03315923 0,08390125 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,03315923 0,08380905 ! lymph node development GO:0048535 9 7 0,000 0,03315923 0,08371705 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,03315923 0,08362526 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,03315923 0,08353366 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,03315923 0,08344227 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,03315923 0,08335107 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,03315923 0,08326008 ! ATP catabolic process GO:0006200 10 7 0,000 0,03315923 0,08316928 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,03315923 0,08307868 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,03315923 0,08298828 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,03315923 0,08289808 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,03315923 0,08280807 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,03315923 0,08271826 ! muscle adaptation GO:0043500 12 7 0,000 0,03315923 0,08262864 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,03315923 0,08253921 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,03315923 0,08244998 ! retina homeostasis GO:0001895 9 7 0,000 0,03315923 0,08236094 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,03315923 0,0822721 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,03315923 0,08218344 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,03315923 0,08209498 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,03315923 0,0820067 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,03315923 0,08191862 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,03315923 0,08183072 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,03315923 0,08174301 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 1,000 0,03373448 0,08307205 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,03373448 0,08298321 ! regulation of homeostatic process GO:0032844 105 60 1,000 0,03373448 0,08289455 ! homeostasis of number of cells GO:0048872 84 61 1,000 0,03477121 0,08535089 ! respiratory tube development GO:0030323 99 62 1,000 0,03582026 0,08783219 ! cAMP-mediated signaling GO:0019933 97 63 1,000 0,03688149 0,09033804 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,03688149 0,09024194 ! viral reproduction GO:0016032 92 63 1,000 0,03688149 0,09014604 ! regulation of lipase activity GO:0060191 109 63 1,000 0,03688149 0,09005034 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,03780671 0,09221148 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,03780671 0,0921138 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,03780671 0,09201632 ! axon extension GO:0048675 11 8 0,000 0,03780671 0,09191905 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,03780671 0,09182199 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,03780671 0,09172513 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,03780671 0,09162848 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,03780671 0,09153203 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,03780671 0,09143578 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,03780671 0,09133973 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,03780671 0,09124389 ! phosphate transport GO:0006817 10 8 0,000 0,03780671 0,09114824 ! N-glycan processing GO:0006491 12 8 0,000 0,03780671 0,0910528 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,03780671 0,09095756 ! UTP metabolic process GO:0046051 8 8 0,000 0,03780671 0,09086251 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,03780671 0,09076767 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,03780671 0,09067302 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,03780671 0,09057857 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,03780671 0,09048431 ! succinate metabolic process GO:0006105 14 8 0,000 0,03780671 0,09039025 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,03780671 0,09029639 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,03780671 0,09020272 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,03780671 0,09010925 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,03780671 0,09001597 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,03780671 0,08992288 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,03780671 0,08982998 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,03780671 0,08973728 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,03780671 0,08964477 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,03780671 0,08955245 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,03780671 0,08946031 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,03780671 0,08936837 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,03780671 0,08927662 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,03780671 0,08918505 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,03780671 0,08909367 ! astrocyte differentiation GO:0048708 16 8 0,000 0,03780671 0,08900248 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,03780671 0,08891148 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,03780671 0,08882066 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,03780671 0,08873003 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,03780671 0,08863958 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,03780671 0,08854931 ! melanin metabolic process GO:0006582 12 8 0,000 0,03780671 0,08845923 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,03780671 0,08836933 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,03780671 0,08827962 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,03780671 0,08819009 ! macrophage activation GO:0042116 12 8 0,000 0,03780671 0,08810073 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,03780671 0,08801156 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,03780671 0,08792257 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,03780671 0,08783376 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,03780671 0,08774513 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,03780671 0,08765668 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,03780671 0,0875684 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,03780671 0,08748031 ! ruffle organization GO:0031529 11 8 0,000 0,03780671 0,08739239 ! osteoblast development GO:0002076 13 8 0,000 0,03780671 0,08730464 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,03780671 0,08721708 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,03780671 0,08712968 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,03780671 0,08704247 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,03780671 0,08695543 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,03780671 0,08686856 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,03780671 0,08678186 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,03780671 0,08669534 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,03780671 0,08660899 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,03780671 0,08652281 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,03780671 0,0864368 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,03780671 0,08635097 ! oligodendrocyte development GO:0014003 8 8 0,000 0,03780671 0,0862653 ! segment specification GO:0007379 10 8 0,000 0,03780671 0,08617981 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,03780671 0,08609448 ! cellular extravasation GO:0045123 11 8 0,000 0,03780671 0,08600932 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,03780671 0,08592433 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,03780671 0,08583951 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,03780671 0,08575486 ! snRNA metabolic process GO:0016073 10 8 0,000 0,03780671 0,08567037 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,03780671 0,08558605 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,03780671 0,08550189 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,03780671 0,0854179 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,03780671 0,08533408 ! nucleosome disassembly GO:0006337 12 8 0,000 0,03780671 0,08525042 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,03780671 0,08516692 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,03780671 0,08508359 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,03780671 0,08500042 ! icosanoid secretion GO:0032309 12 8 0,000 0,03780671 0,08491741 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,03780671 0,08483456 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,03780671 0,08475188 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,03780671 0,08466935 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,03780671 0,08458699 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,03780671 0,08450479 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,03780671 0,08442274 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,03780671 0,08434086 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,03780671 0,08425913 ! sterol catabolic process GO:0016127 9 8 0,000 0,03780671 0,08417757 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,03780671 0,08409616 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,03780671 0,0840149 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,03780671 0,08393381 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,03780671 0,08385287 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,03780671 0,08377209 ! prophase GO:0051324 11 8 0,000 0,03780671 0,08369146 ! S phase GO:0051320 8 8 0,000 0,03780671 0,08361099 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,03780671 0,08353067 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,03780671 0,0834505 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,03780671 0,08337049 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,03780671 0,08329064 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,03780671 0,08321093 ! hormone catabolic process GO:0042447 13 8 0,000 0,03780671 0,08313138 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,03780671 0,08305198 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,03780671 0,08297273 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,03780671 0,08289364 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,03780671 0,08281469 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,03780671 0,08273589 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,03780671 0,08265725 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,03780671 0,08257875 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,03780671 0,0825004 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,03780671 0,0824222 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,03780671 0,08234415 ! lamellipodium assembly GO:0030032 9 8 0,000 0,03780671 0,08226625 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,03780671 0,08218849 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,03780671 0,08211088 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,03780671 0,08203342 ! cell cycle checkpoint GO:0000075 108 64 1,000 0,03795475 0,08227704 ! negative regulation of cell size GO:0045792 108 64 1,000 0,03795475 0,08219956 ! respiratory system development GO:0060541 100 64 1,000 0,03795475 0,08212224 ! regulation of caspase activity GO:0043281 97 65 1,000 0,03903993 0,08439082 ! protein oligomerization GO:0051259 100 65 1,000 0,03903993 0,08431158 ! axon guidance GO:0007411 99 66 1,000 0,04013686 0,08659924 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,04124543 0,08890768 ! learning or memory GO:0007611 123 68 1,000 0,0423655 0,09123657 ! telencephalon cell migration GO:0022029 16 9 0,000 0,04243211 0,09129452 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,04243211 0,0912092 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,04243211 0,09112404 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,04243211 0,09103903 ! CTP metabolic process GO:0046036 9 9 0,000 0,04243211 0,09095419 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,04243211 0,0908695 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,04243211 0,09078497 ! GTP metabolic process GO:0046039 9 9 0,000 0,04243211 0,0907006 ! elastic fiber assembly GO:0048251 13 9 0,000 0,04243211 0,09061638 ! social behavior GO:0035176 14 9 0,000 0,04243211 0,09053232 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,04243211 0,09044842 ! artery development GO:0060840 19 9 0,000 0,04243211 0,09036467 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,04243211 0,09028108 ! response to pain GO:0048265 16 9 0,000 0,04243211 0,09019764 ! protein complex disassembly GO:0043241 17 9 0,000 0,04243211 0,09011435 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,04243211 0,09003122 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,04243211 0,08994824 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,04243211 0,08986542 ! lung alveolus development GO:0048286 17 9 0,000 0,04243211 0,08978275 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,04243211 0,08970022 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,04243211 0,08961786 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,04243211 0,08953564 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,04243211 0,08945357 ! ventral spinal cord development GO:0021517 11 9 0,000 0,04243211 0,08937165 ! protein targeting to ER GO:0045047 19 9 0,000 0,04243211 0,08928989 ! T cell selection GO:0045058 18 9 0,000 0,04243211 0,08920827 ! endoderm development GO:0007492 12 9 0,000 0,04243211 0,0891268 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,04243211 0,08904548 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,04243211 0,08896431 ! arginine catabolic process GO:0006527 10 9 0,000 0,04243211 0,08888328 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,04243211 0,08880241 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,04243211 0,08872168 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,04243211 0,08864109 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,04243211 0,08856066 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,04243211 0,08848037 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,04243211 0,08840022 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,04243211 0,08832022 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,04243211 0,08824037 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,04243211 0,08816065 ! mannose metabolic process GO:0006013 9 9 0,000 0,04243211 0,08808109 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,04243211 0,08800166 ! epithelial cell development GO:0002064 10 9 0,000 0,04243211 0,08792238 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,04243211 0,08784324 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,04243211 0,08776425 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,04243211 0,0876854 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,04243211 0,08760668 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,04243211 0,08752811 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,04243211 0,08744968 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,04243211 0,08737139 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,04243211 0,08729324 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,04243211 0,08721523 ! blastoderm segmentation GO:0007350 11 9 0,000 0,04243211 0,08713736 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,04243211 0,08705963 ! DNA ligation GO:0006266 14 9 0,000 0,04243211 0,08698204 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,04243211 0,08690458 ! response to amine stimulus GO:0014075 13 9 0,000 0,04243211 0,08682726 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,04243211 0,08675008 ! erythrocyte development GO:0048821 11 9 0,000 0,04243211 0,08667304 ! renal water homeostasis GO:0003091 14 9 0,000 0,04243211 0,08659614 ! mRNA cleavage GO:0006379 13 9 0,000 0,04243211 0,08651937 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,04243211 0,08644273 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,04243211 0,08636623 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,04243211 0,08628987 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,04243211 0,08621364 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,04243211 0,08613755 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,04243211 0,08606159 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,04243211 0,08598577 ! acid secretion GO:0046717 14 9 0,000 0,04243211 0,08591007 ! musculoskeletal movement GO:0050881 11 9 0,000 0,04243211 0,08583452 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,04243211 0,08575909 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,04243211 0,0856838 ! purine base metabolic process GO:0006144 18 9 0,000 0,04243211 0,08560864 ! thymus development GO:0048538 15 9 0,000 0,04243211 0,08553361 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,04243211 0,08545871 ! spleen development GO:0048536 15 9 0,000 0,04243211 0,08538394 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,04243211 0,0853093 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,04243211 0,0852348 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,04243211 0,08516042 ! detection of calcium ion GO:0005513 13 9 0,000 0,04243211 0,08508618 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,04243211 0,08501206 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,04243211 0,08493807 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,04243211 0,08486421 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,04243211 0,08479048 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,04243211 0,08471688 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,04243211 0,0846434 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,04243211 0,08457006 ! prepulse inhibition GO:0060134 14 9 0,000 0,04243211 0,08449684 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,04243211 0,08442374 ! insulin secretion GO:0030073 17 9 0,000 0,04243211 0,08435077 ! sequestering of metal ion GO:0051238 11 9 0,000 0,04243211 0,08427793 ! response to nicotine GO:0035094 16 9 0,000 0,04243211 0,08420522 ! establishment of cell polarity GO:0030010 12 9 0,000 0,04243211 0,08413262 ! regulation of synapse organization GO:0050807 12 9 0,000 0,04243211 0,08406016 ! localization within membrane GO:0051668 15 9 0,000 0,04243211 0,08398782 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,04349693 0,08602145 ! eye development GO:0001654 111 70 1,000 0,0446396 0,08820539 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,0446396 0,08812968 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,04579336 0,09032996 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,0469581 0,0925481 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,0469581 0,09246886 GO:0045937|positive regulation of phosphate metabolic process, ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,0469581 0,09238976 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,04703553 0,09246302 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,04703553 0,09238406 ! neuron fate specification GO:0048665 11 10 0,000 0,04703553 0,09230523 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,04703553 0,09222654 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,04703553 0,09214798 ! thyroid gland development GO:0030878 19 10 0,000 0,04703553 0,09206956 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,04703553 0,09199127 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,04703553 0,09191311 ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,04703553 0,09183508 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,04703553 0,09175719 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,04703553 0,09167943 ! sulfate transport GO:0008272 12 10 0,000 0,04703553 0,0916018 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,04703553 0,09152431 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,04703553 0,09144694 ! phospholipid efflux GO:0033700 16 10 0,000 0,04703553 0,0913697 ! hippocampus development GO:0021766 19 10 0,000 0,04703553 0,0912926 ! blood vessel remodeling GO:0001974 21 10 0,000 0,04703553 0,09121562 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,04703553 0,09113878 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,04703553 0,09106206 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,04703553 0,09098548 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,04703553 0,09090902 ! pathogenesis GO:0009405 13 10 0,000 0,04703553 0,09083269 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,04703553 0,09075648 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,04703553 0,09068041 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,04703553 0,09060446 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,04703553 0,09052864 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,04703553 0,09045295 ! melanocyte differentiation GO:0030318 15 10 0,000 0,04703553 0,09037739 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,04703553 0,09030194 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,04703553 0,09022663 ! B cell proliferation GO:0042100 14 10 0,000 0,04703553 0,09015144 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,04703553 0,09007638 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,04703553 0,09000144 ! forebrain cell migration GO:0021885 17 10 0,000 0,04703553 0,08992662 ! lipid digestion GO:0044241 15 10 0,000 0,04703553 0,08985194 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,04703553 0,08977737 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,04703553 0,08970293 ! UV protection GO:0009650 14 10 0,000 0,04703553 0,08962861 ! entry into host cell GO:0030260 20 10 0,000 0,04703553 0,08955441 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,04703553 0,08948034 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,04703553 0,08940639 ! negative regulation of ossification GO:0030279 19 10 0,000 0,04703553 0,08933256 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,04703553 0,08925885 ! regulation of bone resorption GO:0045124 24 10 0,000 0,04703553 0,08918527 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,04703553 0,0891118 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,04703553 0,08903846 ! regulation of organ growth GO:0046620 11 10 0,000 0,04703553 0,08896524 ! response to dsRNA GO:0043331 18 10 0,000 0,04703553 0,08889214 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,04703553 0,08881915 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,04703553 0,08874629 ! embryonic axis specification GO:0000578 12 10 0,000 0,04703553 0,08867355 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,04703553 0,08860093 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,04703553 0,08852842 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,04703553 0,08845603 ! cranial nerve development GO:0021545 12 10 0,000 0,04703553 0,08838377 ! fucose catabolic process GO:0019317 16 10 0,000 0,04703553 0,08831162 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,04703553 0,08823958 ! protein sumoylation GO:0016925 12 10 0,000 0,04703553 0,08816767 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,04703553 0,08809587 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,04703553 0,08802419 ! zymogen activation GO:0031638 14 10 0,000 0,04703553 0,08795263 ! salivary gland development GO:0007431 22 10 0,000 0,04703553 0,08788118 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,04703553 0,08780985 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,04703553 0,08773863 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,04703553 0,08766753 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,04703553 0,08759654 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,04703553 0,08752567 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,04703553 0,08745492 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,04703553 0,08738427 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,04703553 0,08731374 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,04703553 0,08724333 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,04703553 0,08717303 ! detection of bacterium GO:0016045 10 10 0,000 0,04703553 0,08710284 ! embryonic gut development GO:0048566 11 10 0,000 0,04703553 0,08703277 ! activation of innate immune response GO:0002218 10 10 0,000 0,04703553 0,08696281 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,04703553 0,08689296 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,04703553 0,08682322 ! developmental induction GO:0031128 13 10 0,000 0,04703553 0,08675359 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,04703553 0,08668408 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,04703553 0,08661468 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,04703553 0,08654538 ! tube morphogenesis GO:0035239 118 73 1,000 0,04813368 0,08849517 ! protein import into nucleus GO:0006606 118 74 1,000 0,04931997 0,09060378 ! response to nutrient GO:0007584 104 75 1,000 0,05051685 0,09272845 ! nuclear import GO:0051170 121 75 1,000 0,05051685 0,09265451 ! rRNA transcription GO:0009303 17 11 0,000 0,05161709 0,09459707 ! respiratory burst GO:0045730 14 11 0,000 0,05161709 0,09452175 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,05161709 0,09444655 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,05161709 0,09437148 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,05161709 0,09429652 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,05161709 0,09422168 ! RNA polyadenylation GO:0043631 19 11 0,000 0,05161709 0,09414696 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,05161709 0,09407236 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,05161709 0,09399788 ! T cell proliferation GO:0042098 20 11 0,000 0,05161709 0,09392351 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,05161709 0,09384926 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,05161709 0,09377513 ! bone resorption GO:0045453 16 11 0,000 0,05161709 0,09370112 ! regulated secretory pathway GO:0045055 14 11 0,000 0,05161709 0,09362722 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,05161709 0,09355344 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,05161709 0,09347978 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,05161709 0,09340623 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,05161709 0,0933328 ! syncytium formation GO:0006949 15 11 0,000 0,05161709 0,09325948 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,05161709 0,09318628 ! focal adhesion formation GO:0048041 24 11 0,000 0,05161709 0,09311319 ! mitotic spindle organization GO:0007052 15 11 0,000 0,05161709 0,09304022 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,05161709 0,09296736 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,05161709 0,09289461 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,05161709 0,09282198 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,05161709 0,09274947 ! adult heart development GO:0007512 11 11 0,000 0,05161709 0,09267706 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,05161709 0,09260477 ! temperature homeostasis GO:0001659 16 11 0,000 0,05161709 0,09253259 ! L-glutamate transport GO:0015813 16 11 0,000 0,05161709 0,09246053 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,05161709 0,09238857 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,05161709 0,09231673 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,05161709 0,092245 ! stem cell development GO:0048864 29 11 0,000 0,05161709 0,09217338 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,05161709 0,09210188 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,05161709 0,09203048 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,05161709 0,09195919 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,05161709 0,09188802 ! vasoconstriction GO:0042310 15 11 0,000 0,05161709 0,09181695 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,05161709 0,091746 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,05161709 0,09167515 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,05161709 0,09160441 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,05161709 0,09153378 ! ribosome assembly GO:0042255 13 11 0,000 0,05161709 0,09146326 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,05161709 0,09139285 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,05161709 0,09132255 ! chromatin silencing GO:0006342 19 11 0,000 0,05161709 0,09125236 ! nucleosome positioning GO:0016584 13 11 0,000 0,05161709 0,09118227 ! regulation of isotype switching GO:0045191 19 11 0,000 0,05161709 0,09111229 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,05161709 0,09104242 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,05161709 0,09097266 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,05161709 0,090903 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,05161709 0,09083345 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,05161709 0,090764 ! oxygen transport GO:0015671 15 11 0,000 0,05161709 0,09069467 ! male genitalia development GO:0030539 13 11 0,000 0,05161709 0,09062543 ! cholesterol efflux GO:0033344 19 11 0,000 0,05161709 0,09055631 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,05161709 0,09048728 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,05161709 0,09041837 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,05161709 0,09034956 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,05161709 0,09028085 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,05161709 0,09021225 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,05161709 0,09014375 ! defense response to fungus GO:0050832 12 11 0,000 0,05161709 0,09007535 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,05161709 0,09000706 ! lysogeny GO:0030069 18 11 0,000 0,05161709 0,08993888 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,05161709 0,08987079 ! acrosome reaction GO:0007340 13 11 0,000 0,05161709 0,08980281 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,05161709 0,08973493 ! tRNA metabolic process GO:0006399 95 76 1,000 0,05172418 0,08985319 ! regulation of adenylate cyclase activity GO:0045761 131 77 1,000 0,05294186 0,09189907 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,05294186 0,09182977 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,05294186 0,09176056 ! regulation of cyclase activity GO:0031279 132 78 1,000 0,05416974 0,09381807 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,0554077 0,09588993 ! cellular respiration GO:0045333 107 79 1,000 0,0554077 0,09581783 ! regulation of lyase activity GO:0051339 133 79 1,000 0,0554077 0,09574584 ! lactation GO:0007595 20 12 0,000 0,05617689 0,09700214 ! reproductive cellular process GO:0048610 14 12 0,000 0,05617689 0,09692937 ! tRNA modification GO:0006400 14 12 0,000 0,05617689 0,0968567 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,05617689 0,09678415 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,05617689 0,09671171 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,05617689 0,09663937 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,05617689 0,09656715 ! non-recombinational repair GO:0000726 19 12 0,000 0,05617689 0,09649503 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,05617689 0,09642302 ! peroxisomal transport GO:0043574 21 12 0,000 0,05617689 0,09635111 ! cartilage condensation GO:0001502 18 12 0,000 0,05617689 0,09627932 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,05617689 0,09620763 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,05617689 0,09613604 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,05617689 0,09606457 ! heart looping GO:0001947 15 12 0,000 0,05617689 0,0959932 ! palate development GO:0060021 15 12 0,000 0,05617689 0,09592193 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,05617689 0,09585077 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,05617689 0,09577972 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,05617689 0,09570877 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,05617689 0,09563793 ! arginine metabolic process GO:0006525 13 12 0,000 0,05617689 0,09556719 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,05617689 0,09549656 ! methionine metabolic process GO:0006555 13 12 0,000 0,05617689 0,09542603 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,05617689 0,0953556 ! Golgi organization GO:0007030 18 12 0,000 0,05617689 0,09528528 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,05617689 0,09521507 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,05617689 0,09514495 ! monoamine transport GO:0015844 13 12 0,000 0,05617689 0,09507494 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,05617689 0,09500503 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,05617689 0,09493523 ! L-amino acid transport GO:0015807 20 12 0,000 0,05617689 0,09486552 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,05617689 0,09479592 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,05617689 0,09472643 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,05617689 0,09465703 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,05617689 0,09458773 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,05617689 0,09451854 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,05617689 0,09444945 ! cerebellum development GO:0021549 13 12 0,000 0,05617689 0,09438046 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,05617689 0,09431157 ! histone methylation GO:0016571 15 12 0,000 0,05617689 0,09424277 ! autonomic nervous system development GO:0048483 23 12 0,000 0,05617689 0,09417408 ! gland morphogenesis GO:0022612 23 12 0,000 0,05617689 0,09410549 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,05617689 0,094037 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,05617689 0,09396861 ! regulation of epidermis development GO:0045682 17 12 0,000 0,05617689 0,09390032 ! intestinal absorption GO:0050892 19 12 0,000 0,05617689 0,09383213 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,05617689 0,09376404 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,05617689 0,09369604 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,05617689 0,09362815 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,05617689 0,09356035 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,05617689 0,09349265 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,05617689 0,09342505 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,05617689 0,09335755 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,05617689 0,09329014 ! response to cold GO:0009409 14 12 0,000 0,05617689 0,09322283 ! protein localization in nucleus GO:0034504 133 80 1,000 0,05665563 0,0939495 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,05791341 0,09596602 ! regulation of neurological system process GO:0031644 122 81 1,000 0,05791341 0,09589693 ! detection of stimulus GO:0051606 108 82 1,000 0,0591809 0,09792523 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,06045799 0,09996649 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of cell adhesion GO:0030155 159 83 1,000 0,06045799 0,09989468 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,06071502 0,10024734 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,06071502 0,10017543 ! cGMP metabolic process GO:0046068 16 13 0,000 0,06071502 0,10010362 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,06071502 0,10003191 ! water transport GO:0006833 17 13 0,000 0,06071502 0,0999603 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,06071502 0,0998888 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,06071502 0,0998174 ! lipid localization GO:0010876 24 13 0,000 0,06071502 0,0997461 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,06071502 0,09967491 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,06071502 0,09960381 ! organelle fusion GO:0048284 28 13 0,000 0,06071502 0,09953282 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,06071502 0,09946193 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,06071502 0,09939113 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,06071502 0,09932044 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,06071502 0,09924985 ! response to hexose stimulus GO:0009746 19 13 0,000 0,06071502 0,09917936 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,06071502 0,09910897 ! glutamate metabolic process GO:0006536 18 13 0,000 0,06071502 0,09903868 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,06071502 0,09896849 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,06071502 0,0988984 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,06071502 0,09882841 ! NAD metabolic process GO:0019674 21 13 0,000 0,06071502 0,09875852 ! exocrine system development GO:0035272 27 13 0,000 0,06071502 0,09868872 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,06071502 0,09861903 ! bone mineralization GO:0030282 15 13 0,000 0,06071502 0,09854943 ! regulation of exocytosis GO:0017157 17 13 0,000 0,06071502 0,09847993 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,06071502 0,09841053 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,06071502 0,09834123 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,06071502 0,09827202 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,06071502 0,09820291 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,06071502 0,0981339 ! genitalia development GO:0048806 15 13 0,000 0,06071502 0,09806499 ! regulation of cellular pH GO:0030641 20 13 0,000 0,06071502 0,09799617 ! cellular pigmentation GO:0033059 24 13 0,000 0,06071502 0,09792745 ! tissue regeneration GO:0042246 21 13 0,000 0,06071502 0,09785883 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,06071502 0,0977903 ! cofactor transport GO:0051181 19 13 0,000 0,06071502 0,09772186 ! NADP metabolic process GO:0006739 18 13 0,000 0,06071502 0,09765353 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,06071502 0,09758529 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,06071502 0,09751714 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,06071502 0,09744909 ! gas transport GO:0015669 18 13 0,000 0,06071502 0,09738113 ! regulation of RNA stability GO:0043487 28 13 0,000 0,06071502 0,09731327 ! heme biosynthetic process GO:0006783 20 13 0,000 0,06071502 0,0972455 ! regulation of axon extension GO:0030516 23 13 0,000 0,06071502 0,09717783 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,06071502 0,09711025 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,06071502 0,09704277 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,06071502 0,09697538 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,06071502 0,09690808 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,06071502 0,09684088 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,06174457 0,09841477 ! transcription initiation GO:0006352 118 85 1,000 0,06304051 0,10041079 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,06304051 0,1003413 ! regulation of membrane potential GO:0042391 128 85 1,000 0,06304051 0,10027191 ! negative regulation of multicellular organismal process GO:0051241 133 85 1,000 0,06304051 0,10020261 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,0643457 0,10220657 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,0643457 0,10213603 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,06523159 0,10347079 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,06523159 0,10339948 ! superoxide anion generation GO:0042554 18 14 0,000 0,06523159 0,10332827 ! neuron maturation GO:0042551 21 14 0,000 0,06523159 0,10325716 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,06523159 0,10318614 ! myotube differentiation GO:0014902 21 14 0,000 0,06523159 0,10311523 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,06523159 0,1030444 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,06523159 0,10297368 ! inositol metabolic process GO:0006020 20 14 0,000 0,06523159 0,10290305 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,06523159 0,10283252 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,06523159 0,10276209 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,06523159 0,10269175 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,06523159 0,10262151 ! gene silencing by RNA GO:0031047 20 14 0,000 0,06523159 0,10255137 ! response to cAMP GO:0051591 19 14 0,000 0,06523159 0,10248132 ! limbic system development GO:0021761 25 14 0,000 0,06523159 0,10241137 ! startle response GO:0001964 21 14 0,000 0,06523159 0,10234151 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,06523159 0,10227175 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,06523159 0,10220208 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,06523159 0,10213251 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,06523159 0,10206303 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,06523159 0,10199365 ! glycine metabolic process GO:0006544 22 14 0,000 0,06523159 0,10192436 ! pituitary gland development GO:0021983 23 14 0,000 0,06523159 0,10185516 ! cellular response to starvation GO:0009267 21 14 0,000 0,06523159 0,10178606 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,06523159 0,10171705 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,06523159 0,10164814 ! regulation of heart rate GO:0002027 23 14 0,000 0,06523159 0,10157932 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,06523159 0,10151059 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,06523159 0,10144196 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,06523159 0,10137341 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,06523159 0,10130496 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,06523159 0,10123661 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,06523159 0,10116834 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,06523159 0,10110017 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,06523159 0,10103209 ! axon cargo transport GO:0008088 27 14 0,000 0,06523159 0,1009641 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,06523159 0,1008962 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,06523159 0,1008284 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,06523159 0,10076068 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,06523159 0,10069306 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,06523159 0,10062552 ! mRNA splice site selection GO:0006376 26 14 0,000 0,06523159 0,10055808 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,06523159 0,10049073 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,06523159 0,10042346 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,06523159 0,10035629 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,06523159 0,10028921 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,06523159 0,10022221 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,06523159 0,10015531 ! muscle maintenance GO:0046716 19 14 0,000 0,06523159 0,10008849 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,06523159 0,10002177 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,06523159 0,09995513 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,06523159 0,09988858 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,06523159 0,09982212 ! cell killing GO:0001906 20 14 0,000 0,06523159 0,09975575 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,06523159 0,09968947 ! cilium assembly GO:0042384 20 14 0,000 0,06523159 0,09962328 ! peptide hormone secretion GO:0030072 23 14 0,000 0,06523159 0,09955717 ! female pregnancy GO:0007565 130 87 1,000 0,06566002 0,10014459 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,06566002 0,10007822 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,06698335 0,10202762 ! interphase GO:0051325 159 88 1,000 0,06698335 0,1019601 ! protein processing GO:0016485 114 88 1,000 0,06698335 0,10189266 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,06831558 0,10385052 ! regulation of T cell activation GO:0050863 128 89 1,000 0,06831558 0,10378193 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,0697267 0,10585571 ! positive regulation of cell size GO:0045793 20 15 0,000 0,0697267 0,10578588 ! metencephalon development GO:0022037 19 15 0,000 0,0697267 0,10571615 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,0697267 0,10564651 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,0697267 0,10557696 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,0697267 0,1055075 ! skin development GO:0043588 25 15 0,000 0,0697267 0,10543813 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,0697267 0,10536886 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,0697267 0,10529967 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,0697267 0,10523058 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,0697267 0,10516157 ! bile acid metabolic process GO:0008206 22 15 0,000 0,0697267 0,10509266 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,0697267 0,10502384 ! adult walking behavior GO:0007628 25 15 0,000 0,0697267 0,10495511 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,0697267 0,10488646 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,0697267 0,10481791 ! myoblast differentiation GO:0045445 27 15 0,000 0,0697267 0,10474945 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,0697267 0,10468107 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,0697267 0,10461279 ! cerebral cortex development GO:0021987 29 15 0,000 0,0697267 0,10454459 ! response to osmotic stress GO:0006970 22 15 0,000 0,0697267 0,10447648 ! vesicle coating GO:0006901 25 15 0,000 0,0697267 0,10440846 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,0697267 0,10434053 ! DNA integration GO:0015074 22 15 0,000 0,0697267 0,10427269 ! peptide secretion GO:0002790 27 15 0,000 0,0697267 0,10420494 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,0697267 0,10413727 ! regulation of vasodilation GO:0042312 24 15 0,000 0,0697267 0,1040697 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,0697267 0,10400221 ! neuron recognition GO:0008038 22 15 0,000 0,0697267 0,1039348 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,0697267 0,10386749 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,0697267 0,10380026 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,0697267 0,10373312 ! biomineral formation GO:0031214 18 15 0,000 0,0697267 0,10366606 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,0697267 0,1035991 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,0697267 0,10353222 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,0697267 0,10346542 ! dopamine metabolic process GO:0042417 30 15 0,000 0,0697267 0,10339871 ! organic cation transport GO:0015695 19 15 0,000 0,0697267 0,10333209 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,0697267 0,10326555 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,0697267 0,1031991 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,0697267 0,10313273 ! defense response to virus GO:0051607 27 15 0,000 0,0697267 0,10306645 ! peptide hormone processing GO:0016486 19 15 0,000 0,0697267 0,10300026 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,0697267 0,10293415 ! response to virus GO:0009615 122 91 1,000 0,0710063 0,10475592 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,07236455 0,10669133 ! glycerophospholipid metabolic process GO:0006650 130 92 1,000 0,07236455 0,10662298 ! protein secretion GO:0009306 27 16 0,000 0,07420044 0,10925802 ! hormone secretion GO:0046879 25 16 0,000 0,07420044 0,10918811 ! bone remodeling GO:0046849 24 16 0,000 0,07420044 0,1091183 ! endothelial cell migration GO:0043542 22 16 0,000 0,07420044 0,10904858 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,07420044 0,10897894 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,07420044 0,10890939 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,07420044 0,10883994 ! glial cell development GO:0021782 24 16 0,000 0,07420044 0,10877057 ! patterning of blood vessels GO:0001569 24 16 0,000 0,07420044 0,10870129 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,07420044 0,1086321 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,07420044 0,10856299 ! protein polyubiquitination GO:0000209 26 16 0,000 0,07420044 0,10849397 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,07420044 0,10842505 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,07420044 0,1083562 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,07420044 0,10828745 ! fructose metabolic process GO:0006000 20 16 0,000 0,07420044 0,10821878 ! regulation of protein binding GO:0043393 27 16 0,000 0,07420044 0,1081502 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,07420044 0,10808171 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,07420044 0,1080133 ! protein export from nucleus GO:0006611 24 16 0,000 0,07420044 0,10794499 ! negative regulation of immune response GO:0050777 28 16 0,000 0,07420044 0,10787675 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,07420044 0,1078086 ! DNA replication initiation GO:0006270 25 16 0,000 0,07420044 0,10774054 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,07420044 0,10767257 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,07420044 0,10760468 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,07420044 0,10753688 ! diencephalon development GO:0021536 25 16 0,000 0,07420044 0,10746916 ! neural crest cell migration GO:0001755 24 16 0,000 0,07420044 0,10740152 ! G1 phase GO:0051318 27 16 0,000 0,07420044 0,10733398 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,07420044 0,10726651 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,07420044 0,10719913 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,07420044 0,10713184 ! steroid catabolic process GO:0006706 22 16 0,000 0,07420044 0,10706463 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,07420044 0,10699751 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,07420044 0,10693046 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,07420044 0,10686351 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,07420044 0,10679663 ! sperm-egg recognition GO:0035036 16 16 0,000 0,07420044 0,10672984 GO:0007339|binding of sperm to zona pellucida, ! nerve development GO:0021675 18 16 0,000 0,07420044 0,10666314 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,07420044 0,10659652 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,07420044 0,10652998 ! electron transport chain GO:0022900 123 94 1,000 0,07510631 0,10776326 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,07788099 0,11167473 ! protein maturation GO:0051604 129 96 1,000 0,07788099 0,11160515 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,07865293 0,11264119 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,07865293 0,11257109 ! negative regulation of defense response GO:0031348 19 17 0,000 0,07865293 0,11250109 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,07865293 0,11243117 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,07865293 0,11236133 ! glycerol metabolic process GO:0006071 20 17 0,000 0,07865293 0,11229159 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,07865293 0,11222193 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,07865293 0,11215235 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,07865293 0,11208287 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,07865293 0,11201346 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,07865293 0,11194415 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,07865293 0,11187492 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,07865293 0,11180578 ! memory GO:0007613 25 17 0,000 0,07865293 0,11173672 ! keratinization GO:0031424 17 17 0,000 0,07865293 0,11166774 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,07865293 0,11159886 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,07865293 0,11153005 ! retinoid metabolic process GO:0001523 22 17 0,000 0,07865293 0,11146133 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,07865293 0,1113927 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,07865293 0,11132415 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,07865293 0,11125569 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,07865293 0,1111873 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,07865293 0,11111901 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,07865293 0,11105079 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,07865293 0,11098267 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,07865293 0,11091462 ! membrane budding GO:0006900 29 17 0,000 0,07865293 0,11084666 ! heme metabolic process GO:0042168 27 17 0,000 0,07865293 0,11077878 ! actin filament bundle formation GO:0051017 26 17 0,000 0,07865293 0,11071098 ! body fluid secretion GO:0007589 27 17 0,000 0,07865293 0,11064327 ! stem cell differentiation GO:0048863 36 17 0,000 0,07865293 0,11057564 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,07865293 0,11050809 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,07865293 0,11044063 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,07865293 0,11037324 ! sensory perception of pain GO:0019233 23 17 0,000 0,07865293 0,11030594 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,07865293 0,11023872 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,07865293 0,11017159 ! synaptogenesis GO:0007416 24 17 0,000 0,07865293 0,11010453 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,07865293 0,11003756 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,07865293 0,10997067 ! cell-cell junction organization GO:0045216 25 17 0,000 0,07865293 0,10990385 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,07865293 0,10983713 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,07865293 0,10977048 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,07865293 0,10970391 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,07865293 0,10963742 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,07865293 0,10957101 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,0792804 0,11037829 ! extracellular structure organization GO:0043062 156 99 1,000 0,08210285 0,11423869 ! protein import GO:0017038 156 99 1,000 0,08210285 0,11416963 ! positive regulation of translation GO:0045727 28 18 0,000 0,08308426 0,11546453 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,08308426 0,11539481 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,08308426 0,11532517 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,08308426 0,11525561 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,08308426 0,11518614 ! cAMP metabolic process GO:0046058 33 18 0,000 0,08308426 0,11511675 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,08308426 0,11504744 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,08308426 0,11497822 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,08308426 0,11490908 ! axis specification GO:0009798 26 18 0,000 0,08308426 0,11484002 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,08308426 0,11477105 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,08308426 0,11470216 ! pancreas development GO:0031016 26 18 0,000 0,08308426 0,11463335 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,08308426 0,11456463 ! glutamine metabolic process GO:0006541 23 18 0,000 0,08308426 0,11449599 ! response to retinoic acid GO:0032526 25 18 0,000 0,08308426 0,11442743 ! pigmentation during development GO:0048066 31 18 0,000 0,08308426 0,11435895 ! central nervous system neuron development GO:0021954 30 18 0,000 0,08308426 0,11429055 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,08308426 0,11422224 ! fucose metabolic process GO:0006004 26 18 0,000 0,08308426 0,114154 ! response to fungus GO:0009620 19 18 0,000 0,08308426 0,11408585 ! peptide cross-linking GO:0018149 31 18 0,000 0,08308426 0,11401778 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,08308426 0,11394979 ! heart process GO:0003015 27 18 0,000 0,08308426 0,11388188 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,08308426 0,11381406 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,08308426 0,11374631 ! visual learning GO:0008542 35 18 0,000 0,08308426 0,11367864 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,08308426 0,11361106 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,08308426 0,11354355 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,08308426 0,11347613 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,08308426 0,11340878 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,08308426 0,11334152 ! vitamin transport GO:0051180 24 18 0,000 0,08308426 0,11327433 ! hormone transport GO:0009914 27 18 0,000 0,08308426 0,11320723 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,08308426 0,1131402 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,08308426 0,11307325 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,08308426 0,11300639 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,08308426 0,1129396 ! cell-cell recognition GO:0009988 20 18 0,000 0,08308426 0,11287289 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,08308426 0,11280626 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,08308426 0,11273971 ! regulation of glucose import GO:0046324 21 18 0,000 0,08308426 0,11267323 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,08308426 0,11260684 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,08308426 0,11254052 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,08308426 0,11247428 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,08352567 0,11300532 ! protein localization in organelle GO:0033365 161 100 1,000 0,08352567 0,11293889 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,08749453 0,11823585 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,08749453 0,11816642 ! positive regulation of ossification GO:0045778 30 19 0,000 0,08749453 0,11809708 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,08749453 0,11802781 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,08749453 0,11795863 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,08749453 0,11788952 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,08749453 0,1178205 ! regeneration GO:0031099 32 19 0,000 0,08749453 0,11775156 ! sensory perception of taste GO:0050909 23 19 0,000 0,08749453 0,1176827 ! smooth muscle contraction GO:0006939 36 19 0,000 0,08749453 0,11761392 ! peroxisome organization GO:0007031 29 19 0,000 0,08749453 0,11754522 ! digestive system process GO:0022600 30 19 0,000 0,08749453 0,1174766 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,08749453 0,11740806 ! response to vitamin A GO:0033189 26 19 0,000 0,08749453 0,1173396 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,08749453 0,11727122 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,08749453 0,11720292 ! response to starvation GO:0042594 30 19 0,000 0,08749453 0,1171347 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,08749453 0,11706656 ! plasma membrane fusion GO:0045026 23 19 0,000 0,08749453 0,1169985 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,08749453 0,11693052 ! cytolysis GO:0019835 20 19 0,000 0,08749453 0,11686261 ! renal system process GO:0003014 35 19 0,000 0,08749453 0,11679479 ! vasodilation GO:0042311 33 19 0,000 0,08749453 0,11672704 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,08749453 0,11665937 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,08749453 0,11659178 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,08749453 0,11652427 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,08749453 0,11645684 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,08749453 0,11638948 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,08749453 0,11632221 ! sarcomere organization GO:0045214 23 19 0,000 0,08749453 0,11625501 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,08749453 0,11618789 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,08749453 0,11612084 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,08749453 0,11605387 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,08749453 0,11598698 GO:0043450|alkene biosynthetic process, ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,08749453 0,11592017 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,08749453 0,11585344 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,08749453 0,11578678 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,09188384 0,12152549 ! iron ion transport GO:0006826 37 20 0,000 0,09188384 0,12145564 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,09188384 0,12138588 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,09188384 0,1213162 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,09188384 0,1212466 ! response to vitamin GO:0033273 29 20 0,000 0,09188384 0,12117708 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,09188384 0,12110763 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,09188384 0,12103827 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,09188384 0,12096899 ! spinal cord development GO:0021510 31 20 0,000 0,09188384 0,12089978 ! response to ethanol GO:0045471 37 20 0,000 0,09188384 0,12083066 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,09188384 0,12076161 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,09188384 0,12069265 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,09188384 0,12062376 ! chromosome condensation GO:0030261 31 20 0,000 0,09188384 0,12055495 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,09188384 0,12048622 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,09188384 0,12041756 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,09188384 0,12034899 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,09188384 0,12028049 ! pallium development GO:0021543 38 20 0,000 0,09188384 0,12021207 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,09188384 0,12014373 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,09188384 0,12007547 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,09188384 0,12000728 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,09188384 0,11993917 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,09188384 0,11987114 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,09188384 0,11980319 ! collagen catabolic process GO:0030574 25 20 0,000 0,09188384 0,11973531 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,09188384 0,11966751 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,09188384 0,11959979 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,09188384 0,11953214 ! alditol metabolic process GO:0019400 24 20 0,000 0,09188384 0,11946457 ! actin filament-based movement GO:0030048 34 20 0,000 0,09188384 0,11939707 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,09625228 0,12500296 ! regulation of cell killing GO:0031341 34 21 0,000 0,09625228 0,12493242 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,09625228 0,12486195 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,09625228 0,12479157 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,09625228 0,12472126 GO:0009799|determination of symmetry, ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,09625228 0,12465104 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,09625228 0,12458089 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,09625228 0,12451082 ! vesicle docking GO:0048278 27 21 0,000 0,09625228 0,12444083 ! phototransduction GO:0007602 25 21 0,000 0,09625228 0,12437092 ! dendrite development GO:0016358 35 21 0,000 0,09625228 0,12430109 ! visual behavior GO:0007632 39 21 0,000 0,09625228 0,12423134 ! ovarian follicle development GO:0001541 30 21 0,000 0,09625228 0,12416166 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,09625228 0,12409206 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,09625228 0,12402254 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,09625228 0,1239531 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,09625228 0,12388374 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,09625228 0,12381445 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,09625228 0,12374524 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,09625228 0,12367611 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,09625228 0,12360706 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,09625228 0,12353808 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,09625228 0,12346918 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,09625228 0,12340036 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,09625228 0,12333161 ! fatty acid transport GO:0015908 30 21 0,000 0,09625228 0,12326294 ! platelet activation GO:0030168 28 21 0,000 0,09625228 0,12319435 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,09625228 0,12312583 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,09625228 0,12305739 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,09625228 0,12298902 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,09625228 0,12292073 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,09625228 0,12285252 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,09625228 0,12278438 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,09625228 0,12271632 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,09625228 0,12264833 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,09625228 0,12258042 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,09625228 0,12251259 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,09625228 0,12244482 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,09625228 0,12237714 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,09625228 0,12230953 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,09625228 0,12224199 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,10059996 0,1276931 ! regulation of fibroblast proliferation GO:0048145 35 22 0,000 0,10059996 0,12762267 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,10059996 0,12755232 ! viral genome replication GO:0019079 29 22 0,000 0,10059996 0,12748204 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,10059996 0,12741184 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,10059996 0,12734172 ! leukocyte adhesion GO:0007159 38 22 0,000 0,10059996 0,12727167 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,10059996 0,12720171 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,10059996 0,12713181 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,10059996 0,127062 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,10059996 0,12699226 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,10059996 0,1269226 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,10059996 0,12685302 ! lysosome organization GO:0007040 37 22 0,000 0,10059996 0,12678351 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,10059996 0,12671408 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,10059996 0,12664472 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,10059996 0,12657544 ! regulation of behavior GO:0050795 38 22 0,000 0,10059996 0,12650623 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,10059996 0,1264371 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,10059996 0,12636805 ! membrane depolarization GO:0051899 35 22 0,000 0,10059996 0,12629907 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,10059996 0,12623017 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,10059996 0,12616134 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,10059996 0,12609259 ! neural tube closure GO:0001843 33 22 0,000 0,10059996 0,12602391 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,10059996 0,12595531 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,10492697 0,13130143 ! neuron fate commitment GO:0048663 32 23 0,000 0,10492697 0,13123003 ! embryonic pattern specification GO:0009880 31 23 0,000 0,10492697 0,13115871 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,10492697 0,13108747 ! vesicle targeting GO:0006903 32 23 0,000 0,10492697 0,1310163 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,10492697 0,13094521 ! osteoblast differentiation GO:0001649 40 23 0,000 0,10492697 0,1308742 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,10492697 0,13080327 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,10492697 0,13073241 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,10492697 0,13066163 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,10492697 0,13059092 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,10492697 0,1305203 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,10492697 0,13044974 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,10492697 0,13037927 ! cell fate determination GO:0001709 45 23 0,000 0,10492697 0,13030887 ! pentose metabolic process GO:0019321 31 23 0,000 0,10492697 0,13023855 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,10492697 0,1301683 ! spermatid development GO:0007286 33 23 0,000 0,10492697 0,13009813 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,10492697 0,13002803 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,10492697 0,12995801 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,10492697 0,12988807 ! telomere organization GO:0032200 32 23 0,000 0,10492697 0,1298182 GO:0000723|telomere maintenance, ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,10492697 0,1297484 ! regulation of amine transport GO:0051952 38 23 0,000 0,10492697 0,12967868 ! liver development GO:0001889 40 23 0,000 0,10492697 0,12960904 ! initiation of viral infection GO:0019059 42 24 0,000 0,10923341 0,13485606 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,10923341 0,13478371 ! superoxide metabolic process GO:0006801 32 24 0,000 0,10923341 0,13471144 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,10923341 0,13463925 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,10923341 0,13456713 ! fat cell differentiation GO:0045444 37 24 0,000 0,10923341 0,1344951 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,10923341 0,13442313 ! sperm motility GO:0030317 27 24 0,000 0,10923341 0,13435125 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,10923341 0,13427944 ! vacuole organization GO:0007033 39 24 0,000 0,10923341 0,13420771 ! neural crest cell development GO:0014032 39 24 0,000 0,10923341 0,13413606 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,10923341 0,13406448 ! primary neural tube formation GO:0014020 35 24 0,000 0,10923341 0,13399298 ! negative regulation of cell development GO:0010721 56 24 0,000 0,10923341 0,13392156 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,10923341 0,13385021 ! base-excision repair GO:0006284 31 24 0,000 0,10923341 0,13377893 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,10923341 0,13370774 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,10923341 0,13363662 ! glutathione metabolic process GO:0006749 29 24 0,000 0,10923341 0,13356557 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,10923341 0,1334946 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,10923341 0,13342371 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,10923341 0,13335289 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,11351937 0,1385117 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,11351937 0,13843826 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,11351937 0,1383649 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,11351937 0,13829161 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,11351937 0,1382184 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,11351937 0,13814527 ! peptide transport GO:0015833 43 25 0,000 0,11351937 0,13807222 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,11351937 0,13799924 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,11351937 0,13792634 ! phospholipid transport GO:0015914 35 25 0,000 0,11351937 0,13785352 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,11351937 0,13778077 ! detection of light stimulus GO:0009583 30 25 0,000 0,11351937 0,1377081 ! leukocyte proliferation GO:0070661 39 25 0,000 0,11351937 0,13763551 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,11778496 0,14273204 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,11778496 0,14265688 ! translational initiation GO:0006413 43 26 0,000 0,11778496 0,1425818 ! regulation of pH GO:0006885 36 26 0,000 0,11778496 0,14250679 ! circadian rhythm GO:0007623 42 26 0,000 0,11778496 0,14243187 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,11778496 0,14235702 ! post-embryonic development GO:0009791 42 26 0,000 0,11778496 0,14228225 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,11778496 0,14220757 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,11778496 0,14213296 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,11778496 0,14205842 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,11778496 0,14198397 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,11778496 0,14190959 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,11778496 0,14183529 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,11778496 0,14176107 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,12203027 0,14679373 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,12203027 0,146717 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,12203027 0,14664034 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,12203027 0,14656377 ! membrane docking GO:0022406 39 27 0,000 0,12203027 0,14648727 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,12203027 0,14641086 ! catechol metabolic process GO:0009712 43 27 0,000 0,12203027 0,14633452 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,12203027 0,14625827 ! acute-phase response GO:0006953 42 27 0,000 0,12203027 0,14618209 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,12203027 0,14610599 ! myofibril assembly GO:0030239 36 27 0,000 0,12203027 0,14602998 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,12203027 0,14595404 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,12203027 0,14587818 ! natural killer cell activation GO:0030101 35 27 0,000 0,12203027 0,1458024 ! lipid oxidation GO:0034440 38 27 0,000 0,12203027 0,1457267 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,12203027 0,14565107 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,12203027 0,14557553 ! gene silencing GO:0016458 41 27 0,000 0,12203027 0,14550006 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,12625539 0,15045979 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,12625539 0,15038187 ! phenol metabolic process GO:0018958 44 28 0,000 0,12625539 0,15030403 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,12625539 0,15022628 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,12625539 0,1501486 ! cell junction assembly GO:0034329 56 28 0,000 0,12625539 0,150071 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,12625539 0,14999349 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,12625539 0,14991605 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,12625539 0,14983869 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,12625539 0,14976142 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,12625539 0,14968422 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,12625539 0,1496071 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,12625539 0,14953007 GO:0002764|immune response-regulating signal transduction, ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,12625539 0,14945311 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,12625539 0,14937623 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,12625539 0,14929943 ! mesoderm formation GO:0001707 46 28 0,000 0,12625539 0,14922271 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,12625539 0,14914607 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,12625539 0,1490695 ! BMP signaling pathway GO:0030509 40 28 0,000 0,12625539 0,14899302 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,12625539 0,14891661 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,12625539 0,14884028 ! neural tube formation GO:0001841 41 28 0,000 0,12625539 0,14876403 ! regulation of B cell activation GO:0050864 42 28 0,000 0,12625539 0,14868786 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,13046041 0,15356139 ! regulation of innate immune response GO:0045088 38 29 0,000 0,13046041 0,15348284 ! ovulation cycle process GO:0022602 41 29 0,000 0,13046041 0,15340437 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,13046041 0,15332599 ! protein targeting to membrane GO:0006612 53 29 0,000 0,13046041 0,15324768 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,13046041 0,15316945 ! muscle cell development GO:0055001 38 29 0,000 0,13046041 0,1530913 ! formation of primary germ layer GO:0001704 48 29 0,000 0,13046041 0,15301323 ! telencephalon development GO:0021537 52 29 0,000 0,13046041 0,15293525 ! eye morphogenesis GO:0048592 51 29 0,000 0,13046041 0,15285734 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,13046041 0,15277951 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,13464544 0,15760027 ! collagen metabolic process GO:0032963 40 30 0,000 0,13464544 0,1575201 ! organic anion transport GO:0015711 51 30 0,000 0,13464544 0,15744002 ! cholesterol transport GO:0030301 46 30 0,000 0,13464544 0,15736002 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,13464544 0,1572801 ! spliceosome assembly GO:0000245 49 30 0,000 0,13464544 0,15720027 ! spindle organization GO:0007051 37 30 0,000 0,13464544 0,15712051 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,13464544 0,15704083 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,13464544 0,15696124 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,13464544 0,15688172 ! ceramide metabolic process GO:0006672 43 30 0,000 0,13464544 0,15680229 ! ovulation cycle GO:0042698 43 30 0,000 0,13464544 0,15672294 ! hindbrain development GO:0030902 45 30 0,000 0,13464544 0,15664366 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,13464544 0,15656447 ! adult locomotory behavior GO:0008344 47 30 0,000 0,13464544 0,15648536 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,13464544 0,15640632 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,13464544 0,15632737 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,13464544 0,1562485 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,13464544 0,1561697 ! glial cell differentiation GO:0010001 55 31 0,000 0,13881057 0,16091951 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,13881057 0,16083844 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,13881057 0,16075746 ! odontogenesis GO:0042476 50 31 0,000 0,13881057 0,16067655 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,13881057 0,16059573 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,13881057 0,16051499 ! metanephros development GO:0001656 58 31 0,000 0,13881057 0,16043433 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,13881057 0,16035375 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,13881057 0,16027325 ! cell fate specification GO:0001708 37 31 0,000 0,13881057 0,16019283 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,13881057 0,16011249 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,13881057 0,16003224 ! RNA modification GO:0009451 40 31 0,000 0,13881057 0,15995206 ! regulation of muscle development GO:0048634 48 32 0,000 0,14295589 0,16464624 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,14295589 0,16456383 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,14295589 0,16448151 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,14295589 0,16439927 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,14295589 0,16431711 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,14295589 0,16423503 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,14295589 0,16415304 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,14295589 0,16407113 ! cytokine production GO:0001816 44 32 0,000 0,14295589 0,1639893 ! vesicle localization GO:0051648 47 32 0,000 0,14295589 0,16390755 ! RNA export from nucleus GO:0006405 44 33 0,000 0,14708149 0,16855377 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,14708149 0,16846983 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,14708149 0,16838597 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,14708149 0,1683022 ! sister chromatid segregation GO:0000819 46 33 0,000 0,14708149 0,16821851 ! actomyosin structure organization GO:0031032 43 33 0,000 0,14708149 0,1681349 ! cell junction organization GO:0034330 63 33 0,000 0,14708149 0,16805137 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,14708149 0,16796793 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,14708149 0,16788457 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,14708149 0,1678013 ! positive regulation of cell development GO:0010720 54 33 0,000 0,14708149 0,1677181 ! lipid homeostasis GO:0055088 55 33 0,000 0,14708149 0,16763499 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,14708149 0,16755197 ! negative regulation of hydrolase activity GO:0051346 50 33 0,000 0,14708149 0,16746902 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,14708149 0,16738615 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,14708149 0,16730337 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,15118746 0,17188886 ! mRNA catabolic process GO:0006402 48 34 0,000 0,15118746 0,17180393 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,15118746 0,17171909 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,15118746 0,17163433 ! feeding behavior GO:0007631 45 34 0,000 0,15118746 0,17154966 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,15118746 0,17146507 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,15118746 0,17138056 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,15118746 0,17129614 ! neuron migration GO:0001764 46 34 0,000 0,15118746 0,1712118 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,15118746 0,17112754 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,15118746 0,17104336 ! polyol metabolic process GO:0019751 44 34 0,000 0,15118746 0,17095927 ! aerobic respiration GO:0009060 47 34 0,000 0,15118746 0,17087526 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,15118746 0,17079134 ! embryonic organ development GO:0048568 45 34 0,000 0,15118746 0,17070749 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,15118746 0,17062373 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,1552739 0,17514957 ! Notch signaling pathway GO:0007219 56 35 0,000 0,1552739 0,17506371 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,1552739 0,17497794 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,1552739 0,17489225 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,1552739 0,17480665 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,1552739 0,17472112 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,1552739 0,17463569 ! pigment metabolic process GO:0042440 61 35 0,000 0,1552739 0,17455033 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,1552739 0,17446506 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,1552739 0,17437987 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,15934091 0,17885997 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,15934091 0,17877272 ! organic ether metabolic process GO:0018904 46 36 0,000 0,15934091 0,17868556 ! tissue remodeling GO:0048771 62 36 0,000 0,15934091 0,17859848 ! neural tube development GO:0021915 50 36 0,000 0,15934091 0,17851149 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,15934091 0,17842458 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,15934091 0,17833775 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,15934091 0,17825101 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,16338856 0,18269017 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,16338856 0,1826014 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,16338856 0,18251272 ! ion transmembrane transport GO:0034220 56 37 0,000 0,16338856 0,18242412 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,16338856 0,18233561 ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,16338856 0,18224718 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,16741696 0,18665002 ! gliogenesis GO:0042063 71 38 0,000 0,16741696 0,18655959 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,16741696 0,18646925 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,16741696 0,18637899 ! phagocytosis GO:0006909 60 38 0,000 0,16741696 0,18628882 ! mesenchymal cell development GO:0014031 64 38 0,000 0,16741696 0,18619874 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,17142618 0,1905656 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,17142618 0,19047354 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,17142618 0,19038157 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,17142618 0,19028968 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,17142618 0,19019789 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,17142618 0,19010618 ! chromatin remodeling GO:0006338 68 39 0,000 0,17142618 0,19001456 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,17142618 0,18992304 ! JNK cascade GO:0007254 54 39 0,000 0,17142618 0,18983159 ! cell growth GO:0016049 61 39 0,000 0,17142618 0,18974024 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,17541633 0,19406328 ! response to calcium ion GO:0051592 58 40 0,000 0,17541633 0,19396998 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,17541633 0,19387677 ! regulation of tube size GO:0035150 60 40 0,000 0,17541633 0,19378365 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,17541633 0,19369062 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,17541633 0,19359768 ! peptide metabolic process GO:0006518 56 40 0,000 0,17541633 0,19350483 ! inner ear development GO:0048839 57 40 0,000 0,17541633 0,19341207 ! T cell differentiation GO:0030217 65 40 0,000 0,17541633 0,19331939 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,17541633 0,1932268 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,17541633 0,19313431 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,1793875 0,19741208 ! striated muscle contraction GO:0006941 62 41 0,000 0,1793875 0,19731767 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,1793875 0,19722335 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,1793875 0,19712912 ! mitochondrial transport GO:0006839 60 42 0,000 0,18333976 0,20137605 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,18333976 0,20127993 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,18333976 0,2011839 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,18333976 0,20108796 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,18333976 0,20099211 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,18333976 0,20089636 ! excretion GO:0007588 63 42 0,000 0,18333976 0,20080069 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,18333976 0,20070512 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,18333976 0,20060964 ! regulation of cell shape GO:0008360 78 42 0,000 0,18333976 0,20051424 ! leukocyte migration GO:0050900 60 43 0,000 0,18727322 0,20471882 ! neuromuscular process GO:0050905 79 43 0,000 0,18727322 0,20462157 ! tRNA processing GO:0008033 49 43 0,000 0,18727322 0,20452441 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,18727322 0,20442734 ! vesicle organization GO:0016050 79 43 0,000 0,18727322 0,20433036 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,18727322 0,20423348 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,19118795 0,20840393 ! glycolysis GO:0006096 53 44 0,000 0,19118795 0,20830521 ! regulation of ion transport GO:0043269 57 44 0,000 0,19118795 0,20820658 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,19118795 0,20810804 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,19118795 0,2080096 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,19118795 0,20791125 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,19118795 0,20781299 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,19118795 0,20771483 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,19118795 0,20761676 ! RNA catabolic process GO:0006401 64 45 0,000 0,19508405 0,21174767 ! positive regulation of defense response GO:0031349 59 45 0,000 0,19508405 0,21164779 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,19508405 0,21154801 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,19508405 0,21144831 ! cell recognition GO:0008037 58 45 0,000 0,19508405 0,21134871 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,19896161 0,21544807 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,19896161 0,21534668 ! cell redox homeostasis GO:0045454 63 46 0,000 0,19896161 0,21524539 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,19896161 0,21514419 ! regulation of ossification GO:0030278 71 46 0,000 0,19896161 0,21504309 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,19896161 0,21494209 ! viral infectious cycle GO:0019058 71 47 0,000 0,20282071 0,21900827 ! endocrine system development GO:0035270 83 47 0,000 0,20282071 0,2189055 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,20282071 0,21880283 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,20282071 0,21870025 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,20282071 0,21859776 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,20282071 0,21849537 ! chloride transport GO:0006821 67 48 0,000 0,20666143 0,2225287 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,20666143 0,22242456 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,20666143 0,22232053 ! gastrulation GO:0007369 73 48 0,000 0,20666143 0,22221659 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,20666143 0,22211275 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,20666143 0,22200901 ! regulation of endocytosis GO:0030100 63 48 0,000 0,20666143 0,22190537 ! nuclear export GO:0051168 69 48 0,000 0,20666143 0,22180182 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,20666143 0,22169836 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,21048387 0,22569366 ! sensory perception of smell GO:0007608 61 49 0,000 0,21048387 0,22558849 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,21048387 0,22548342 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,21048387 0,22537845 ! RNA elongation GO:0006354 62 49 0,000 0,21048387 0,22527357 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,21048387 0,22516879 ! cartilage development GO:0051216 70 49 0,000 0,21048387 0,22506411 ! regulation of actin filament length GO:0030832 72 50 0,000 0,21428812 0,2290254 ! membrane fusion GO:0006944 80 50 0,000 0,21428812 0,22891903 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,21428812 0,22881275 ! proton transport GO:0015992 75 50 0,000 0,21428812 0,22870657 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,21428812 0,22860049 ! positive regulation of secretion GO:0051047 71 51 0,000 0,21807424 0,23253165 ! hydrogen transport GO:0006818 77 51 0,000 0,21807424 0,23242389 ! adult behavior GO:0030534 80 51 0,000 0,21807424 0,23231624 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,21807424 0,23220869 ! transition metal ion transport GO:0000041 74 52 0,000 0,22184235 0,2361117 ! regulation of cellular component size GO:0032535 74 52 0,000 0,22184235 0,23600249 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,22184235 0,23589339 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,2255925 0,23977022 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,2255925 0,23965947 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,2255925 0,23954883 ! kidney development GO:0001822 90 53 0,000 0,2255925 0,23943828 ! single fertilization GO:0007338 59 53 0,000 0,2255925 0,23932784 ! amino acid transport GO:0006865 84 54 0,000 0,2293248 0,24317522 ! glucose catabolic process GO:0006007 66 54 0,000 0,2293248 0,24306315 ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,2293248 0,24295119 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,2293248 0,24283934 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,2293248 0,24272759 ! exocytosis GO:0006887 74 55 0,000 0,23303932 0,24654574 ! mesoderm development GO:0007498 76 55 0,000 0,23303932 0,24643239 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,23303932 0,24631914 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,23303932 0,24620599 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,23673616 0,24999686 ! negative regulation of protein kinase activity GO:0006469 99 57 0,000 0,24041538 0,25376566 ! chromosome segregation GO:0007059 83 57 0,000 0,24041538 0,25364926 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,24041538 0,25353296 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,24041538 0,25341676 ! camera-type eye development GO:0043010 88 57 0,000 0,24041538 0,25330068 ! secondary metabolic process GO:0019748 84 57 0,000 0,24041538 0,2531847 ! negative regulation of kinase activity GO:0033673 100 58 0,000 0,24407708 0,25692324 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,24407708 0,25680571 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,24407708 0,25668829 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,24772134 0,26040177 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,24772134 0,26028281 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,25134823 0,26397303 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,25134823 0,26385255 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,25134823 0,26373218 ! regulation of heart contraction GO:0008016 91 60 0,000 0,25134823 0,26361192 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,25134823 0,26349177 ! fertilization GO:0009566 68 60 0,000 0,25134823 0,26337172 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,25495785 0,26703236 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,25495785 0,26691081 ! urogenital system development GO:0001655 101 61 0,000 0,25495785 0,26678938 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,25495785 0,26666806 ! extracellular matrix organization GO:0030198 103 61 0,000 0,25495785 0,26654684 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,25495785 0,26642574 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! negative regulation of transferase activity GO:0051348 105 61 0,000 0,25495785 0,26630475 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,25495785 0,26618387 ! amine catabolic process GO:0009310 90 62 0,000 0,25855027 0,26981199 ! neurotransmitter transport GO:0006836 81 62 0,000 0,25855027 0,26968962 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,25855027 0,26956737 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,25855027 0,26944523 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,25855027 0,2693232 ! appendage morphogenesis GO:0035107 93 64 0,000 0,26568384 0,27662871 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,26568384 0,27650354 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,26568384 0,27637848 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,26568384 0,27625354 ! hexose catabolic process GO:0019320 82 64 0,000 0,26568384 0,27612871 ! appendage development GO:0048736 94 65 0,000 0,26922515 0,27968286 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,26922515 0,27955659 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,26922515 0,27943044 ! defense response to bacterium GO:0042742 73 65 0,000 0,26922515 0,2793044 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,26922515 0,27917847 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,26922515 0,27905266 ! activation of immune response GO:0002253 83 65 0,000 0,26922515 0,27892696 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,27274959 0,28245117 ! antigen processing and presentation GO:0019882 96 66 0,000 0,27274959 0,28232405 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,27274959 0,28219705 ! regulation of immune effector process GO:0002697 101 66 0,000 0,27274959 0,28207016 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,27625722 0,28556927 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,27625722 0,28544098 ! acute inflammatory response GO:0002526 92 68 0,000 0,27974815 0,28891816 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,27974815 0,28878848 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,27974815 0,28865892 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,27974815 0,28852948 ! rhythmic process GO:0048511 105 68 0,000 0,27974815 0,28840015 ! inorganic anion transport GO:0015698 93 68 0,000 0,27974815 0,28827094 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,28322243 0,29172037 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,28322243 0,29158979 ! response to metal ion GO:0010038 103 70 0,000 0,28668015 0,2950176 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,28668015 0,29488566 ! humoral immune response GO:0006959 86 70 0,000 0,28668015 0,29475384 ! amine transport GO:0015837 101 70 0,000 0,28668015 0,29462214 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,28668015 0,29449055 ! muscle cell differentiation GO:0042692 104 71 0,000 0,29012139 0,2978925 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,29012139 0,29775957 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,29012139 0,29762676 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,29012139 0,29749407 ! negative regulation of organelle organization GO:0010639 115 72 0,000 0,29354623 0,3008718 ! regulation of blood pressure GO:0008217 107 73 0,000 0,29695473 0,30422979 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,29695473 0,30409434 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,30034699 0,30743128 ! digestion GO:0007586 97 74 0,000 0,30034699 0,30729452 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,30034699 0,30715788 ! response to inorganic substance GO:0010035 115 75 0,000 0,30372307 0,31047247 ! negative regulation of growth GO:0045926 123 75 0,000 0,30372307 0,31033455 ! regulation of ligase activity GO:0051340 114 75 0,000 0,30372307 0,31019674 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,30372307 0,31005906 ! amine biosynthetic process GO:0009309 97 76 0,000 0,30708306 0,31335006 ! response to unfolded protein GO:0006986 99 76 0,000 0,30708306 0,3132111 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,30708306 0,31307227 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,31042702 0,31634123 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,31375504 0,31959105 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,31375504 0,31944957 ! T cell activation GO:0042110 134 79 0,000 0,31706718 0,32267899 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,31706718 0,32253628 ! chromatin assembly GO:0031497 102 80 0,000 0,32036353 0,32574541 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,32036353 0,32560147 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,32036353 0,32545765 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,32036353 0,32531396 ! forebrain development GO:0030900 131 80 0,000 0,32036353 0,3251704 ! mRNA transport GO:0051028 121 81 0,000 0,32364416 0,32835534 ! response to protein stimulus GO:0051789 111 81 0,000 0,32364416 0,32821057 ! vitamin metabolic process GO:0006766 103 81 0,000 0,32364416 0,32806592 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,32364416 0,32792139 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,32690914 0,33108367 GO:0060348|bone development, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,33015854 0,3342274 ! regulation of defense response GO:0031347 117 84 0,000 0,33339244 0,33735267 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,33339244 0,33720432 ! sterol metabolic process GO:0016125 120 84 0,000 0,33339244 0,3370561 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,33661092 0,34016042 ! rRNA metabolic process GO:0016072 107 85 0,000 0,33661092 0,34001103 GO:0006364|rRNA processing, ! nucleosome organization GO:0034728 114 87 0,000 0,34300188 0,34631445 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,34300188 0,34616249 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,3461745 0,34921112 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,3461745 0,34905803 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,3461745 0,34890507 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! regulation of neurogenesis GO:0050767 153 89 0,000 0,34933199 0,35193324 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,34933199 0,35177915 ! hormone metabolic process GO:0042445 121 90 0,000 0,35247441 0,35478825 ! RNA localization GO:0006403 135 91 0,000 0,35560184 0,35777962 ! ATP metabolic process GO:0046034 137 91 0,000 0,35560184 0,35762318 ! cell fate commitment GO:0045165 141 92 0,000 0,35871433 0,3605957 ! positive regulation of immune response GO:0050778 121 92 0,000 0,35871433 0,36043817 ! sulfur metabolic process GO:0006790 118 92 0,000 0,35871433 0,36028077 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,36181197 0,36323332 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,36181197 0,36307484 ! carboxylic acid transport GO:0046942 147 95 0,000 0,36796297 0,36908628 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,37101647 0,37198687 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,37405538 0,37487032 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,38008976 0,38075194 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,38308536 0,38358569 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,38308536 0,38341877 ! divalent metal ion transport GO:0070838 171 100 0,000 0,38308536 0,38325199 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,38308536 0,38308536