pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6231-IPC-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! phospholipid dephosphorylation GO:0046839 12 5 3,000 9,34E-10 2,282E-06 ! cellular response to hormone stimulus GO:0032870 182 85 7,000 1,174E-09 1,434E-06 ! regulation of cyclin-dependent protein kinase activity GO:0000079 111 57 6,000 1,981E-09 1,613E-06 ! negative regulation of protein kinase B signaling cascade GO:0051898 14 6 3,000 2,794E-09 1,706E-06 ! regulation of protein export from nucleus GO:0046825 10 7 3,000 6,5E-09 3,176E-06 ! organ growth GO:0035265 15 7 3,000 6,5E-09 2,647E-06 ! negative regulation of peptide secretion GO:0002792 10 7 3,000 6,5E-09 2,269E-06 GO:0046676|negative regulation of insulin secretion, ! negative regulation of focal adhesion formation GO:0051895 21 7 3,000 6,5E-09 1,985E-06 ! regulation of focal adhesion formation GO:0051893 23 8 3,000 1,296E-08 3,519E-06 ! regulation of growth hormone secretion GO:0060123 16 8 3,000 1,296E-08 3,167E-06 ! regulation of cell-matrix adhesion GO:0001952 81 23 4,000 2,168E-08 4,814E-06 GO:0010810|regulation of cell-substrate adhesion, ! nerve growth factor receptor signaling pathway GO:0048011 20 9 3,000 2,327E-08 4,736E-06 ! regulation of protein kinase B signaling cascade GO:0051896 27 10 3,000 3,866E-08 7,266E-06 ! insulin receptor signaling pathway GO:0008286 66 27 4,000 5,139E-08 8,967E-06 ! negative regulation of cell-matrix adhesion GO:0001953 37 11 3,000 6,058E-08 9,866E-06 GO:0010812|negative regulation of cell-substrate adhesion, ! epidermal growth factor receptor signaling pathway GO:0007173 69 28 4,000 6,237E-08 9,523E-06 ! positive regulation of MAP kinase activity GO:0043406 174 93 6,000 6,349E-08 9,124E-06 ! negative regulation of secretion GO:0051048 68 35 4,000 2,017E-07 2,738E-05 ! activation of MAPK activity GO:0000187 124 67 5,000 2,028E-07 2,607E-05 ! negative regulation of cell adhesion GO:0007162 94 37 4,000 2,693E-07 3,289E-05 ! regulation of protein stability GO:0031647 77 38 4,000 3,091E-07 3,596E-05 ! cellular response to insulin stimulus GO:0032869 85 38 4,000 3,091E-07 3,433E-05 ! carbohydrate homeostasis GO:0033500 59 39 4,000 3,535E-07 3,755E-05 GO:0042593|glucose homeostasis, ! negative regulation of hormone secretion GO:0046888 26 17 3,000 4,294E-07 4,37E-05 ! endothelial cell migration GO:0043542 31 17 3,000 4,294E-07 4,196E-05 ! platelet-derived growth factor receptor signaling pathway GO:0048008 31 17 3,000 4,294E-07 4,034E-05 ! cardiac muscle tissue development GO:0048738 34 17 3,000 4,294E-07 3,885E-05 ! positive regulation of hormone secretion GO:0046887 35 19 3,000 6,952E-07 6,066E-05 ! inositol metabolic process GO:0006020 33 19 3,000 6,952E-07 5,856E-05 ! response to insulin stimulus GO:0032868 98 47 4,000 9,195E-07 7,488E-05 ! nuclear migration GO:0007097 13 6 2,000 1,016E-06 8,007E-05 ! positive regulation of pseudopodium assembly GO:0031274 15 6 2,000 1,016E-06 7,756E-05 GO:0031272|regulation of pseudopodium assembly, ! regulation of cell adhesion GO:0030155 241 92 5,000 1,342E-06 9,935E-05 ! positive regulation of DNA replication GO:0045740 44 23 3,000 1,57E-06 1,128E-04 ! interphase of mitotic cell cycle GO:0051329 224 98 5,000 1,945E-06 1,358E-04 ! regulation of insulin secretion GO:0050796 42 25 3,000 2,23E-06 1,513E-04 ! peptidyl-tyrosine phosphorylation GO:0018108 55 26 3,000 2,627E-06 1,735E-04 ! regulation of lipid kinase activity GO:0043550 17 8 2,000 2,829E-06 1,819E-04 ! establishment of nucleus localization GO:0040023 18 8 2,000 2,829E-06 1,772E-04 ! lipid modification GO:0030258 112 60 4,000 3,149E-06 1,923E-04 ! peptidyl-tyrosine modification GO:0018212 57 28 3,000 3,578E-06 2,132E-04 ! DNA damage response, signal transduction GO:0042770 136 62 4,000 3,709E-06 2,157E-04 ! regulation of peptide secretion GO:0002791 52 29 3,000 4,138E-06 2,351E-04 ! macrophage differentiation GO:0030225 15 9 2,000 4,232E-06 2,35E-04 ! positive regulation of myeloid leukocyte differentiation GO:0002763 25 9 2,000 4,232E-06 2,298E-04 ! response to peptide hormone stimulus GO:0043434 129 64 4,000 4,344E-06 2,307E-04 ! negative regulation of protein kinase cascade GO:0010741 72 30 3,000 4,761E-06 2,475E-04 ! triglyceride metabolic process GO:0006641 46 33 3,000 7,047E-06 3,587E-04 ! nucleus localization GO:0051647 22 11 2,000 8,268E-06 4,122E-04 ! DNA damage checkpoint GO:0000077 78 35 3,000 8,965E-06 4,38E-04 ! phosphoinositide metabolic process GO:0030384 146 77 4,000 1,083E-05 5,186E-04 ! regulation of cell projection assembly GO:0060491 33 12 2,000 1,099E-05 5,165E-04 ! positive regulation of DNA metabolic process GO:0051054 77 38 3,000 1,253E-05 5,775E-04 ! neutral lipid metabolic process GO:0006638 54 38 3,000 1,253E-05 5,668E-04 GO:0006639|acylglycerol metabolic process, ! DNA integrity checkpoint GO:0031570 82 38 3,000 1,253E-05 5,565E-04 ! glycerol ether metabolic process GO:0006662 57 40 3,000 1,542E-05 6,728E-04 ! regulation of hormone secretion GO:0046883 69 41 3,000 1,704E-05 7,304E-04 ! negative regulation of transport GO:0051051 164 85 4,000 1,755E-05 7,392E-04 ! organic ether metabolic process GO:0018904 59 42 3,000 1,878E-05 7,776E-04 ! regulation of intracellular protein transport GO:0033157 86 42 3,000 1,878E-05 7,647E-04 ! hormone-mediated signaling GO:0009755 84 43 3,000 2,065E-05 8,269E-04 ! regulation of myeloid cell differentiation GO:0045637 105 43 3,000 2,065E-05 8,135E-04 ! regulation of epithelial cell proliferation GO:0050678 122 45 3,000 2,478E-05 9,61E-04 ! polyol metabolic process GO:0019751 77 45 3,000 2,478E-05 9,46E-04 ! regulation of nucleocytoplasmic transport GO:0046822 92 46 3,000 2,706E-05 1,017E-03 ! negative regulation of cell migration GO:0030336 122 46 3,000 2,706E-05 1,002E-03 ! positive regulation of cell cycle GO:0045787 96 48 3,000 3,208E-05 1,17E-03 ! filopodium assembly GO:0046847 42 17 2,000 3,352E-05 1,204E-03 ! positive regulation of nitric oxide biosynthetic process GO:0045429 39 18 2,000 4,011E-05 1,42E-03 ! microspike assembly GO:0030035 46 18 2,000 4,011E-05 1,4E-03 ! negative regulation of epithelial cell proliferation GO:0050680 48 19 2,000 4,75E-05 1,634E-03 ! regulation of multicellular organism growth GO:0040014 90 55 3,000 5,511E-05 1,87E-03 ! negative regulation of cell motion GO:0051271 142 55 3,000 5,511E-05 1,844E-03 ! positive regulation of angiogenesis GO:0045766 50 20 2,000 5,573E-05 1,84E-03 ! positive regulation of myeloid cell differentiation GO:0045639 63 20 2,000 5,573E-05 1,815E-03 ! regulation of DNA replication GO:0006275 105 56 3,000 5,918E-05 1,902E-03 ! regulation of intracellular transport GO:0032386 108 57 3,000 6,346E-05 2,013E-03 ! regulation of nitric oxide biosynthetic process GO:0045428 44 21 2,000 6,484E-05 2,031E-03 ! regulation of myeloid leukocyte differentiation GO:0002761 41 22 2,000 7,487E-05 2,315E-03 ! positive regulation of secretion GO:0051047 110 61 3,000 8,287E-05 2,531E-03 ! regulation of oxidoreductase activity GO:0051341 48 24 2,000 9,787E-05 2,952E-03 ! multicellular organism reproduction GO:0032504 123 65 3,000 1,063E-04 3,166E-03 GO:0048609|reproductive process in a multicellular organism, ! positive regulation of fibroblast proliferation GO:0048146 48 25 2,000 1,109E-04 3,264E-03 ! myeloid leukocyte differentiation GO:0002573 46 25 2,000 1,109E-04 3,226E-03 ! G2/M transition of mitotic cell cycle GO:0000086 45 25 2,000 1,109E-04 3,188E-03 ! interaction with host GO:0051701 66 25 2,000 1,109E-04 3,151E-03 ! cell projection assembly GO:0030031 138 68 3,000 1,267E-04 3,559E-03 ! protein maturation by protein folding GO:0022417 14 5 1,000 1,379E-04 3,829E-03 ! positive regulation of glycolysis GO:0045821 13 5 1,000 1,379E-04 3,786E-03 ! microvillus organization GO:0032528 8 5 1,000 1,379E-04 3,744E-03 GO:0030033|microvillus assembly, ! sister chromatid cohesion GO:0007062 15 5 1,000 1,379E-04 3,703E-03 ! regulation of retinoic acid receptor signaling pathway GO:0048385 12 5 1,000 1,379E-04 3,663E-03 ! regulation of phospholipase A2 activity GO:0032429 15 5 1,000 1,379E-04 3,624E-03 ! sequestering of calcium ion GO:0051208 7 5 1,000 1,379E-04 3,585E-03 ! protein insertion into membrane GO:0051205 17 5 1,000 1,379E-04 3,547E-03 ! positive regulation of cell projection organization GO:0031346 66 27 2,000 1,403E-04 3,57E-03 ! cell cycle checkpoint GO:0000075 145 71 3,000 1,499E-04 3,775E-03 ! regulation of fibroblast proliferation GO:0048145 56 28 2,000 1,567E-04 3,906E-03 ! negative regulation of protein complex assembly GO:0031333 68 30 2,000 1,931E-04 4,765E-03 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 27 6 1,000 2,064E-04 5,043E-03 ! negative regulation of osteoblast differentiation GO:0045668 17 6 1,000 2,064E-04 4,993E-03 ! symbiosis, encompassing mutualism through parasitism GO:0044403 79 34 2,000 2,815E-04 6,743E-03 ! prostate gland development GO:0030850 14 7 1,000 2,883E-04 6,837E-03 ! N-terminal protein amino acid acetylation GO:0006474 14 7 1,000 2,883E-04 6,771E-03 ! glucocorticoid receptor signaling pathway GO:0042921 16 7 1,000 2,883E-04 6,707E-03 GO:0031958|corticosteroid receptor signaling pathway, ! male sex determination GO:0030238 15 7 1,000 2,883E-04 6,644E-03 ! regulation of meiosis GO:0040020 12 7 1,000 2,883E-04 6,582E-03 GO:0051445|regulation of meiotic cell cycle, ! regulation of protein transport GO:0051223 165 87 3,000 3,279E-04 7,418E-03 GO:0070201|regulation of establishment of protein localization, ! regulation of cell cycle process GO:0010564 161 90 3,000 3,732E-04 8,364E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 26 8 1,000 3,834E-04 8,515E-03 ! oligopeptide transport GO:0006857 16 8 1,000 3,834E-04 8,438E-03 ! Schwann cell differentiation GO:0014037 21 8 1,000 3,834E-04 8,363E-03 ! phosphoinositide 3-kinase cascade GO:0014065 29 8 1,000 3,834E-04 8,289E-03 ! regulation of respiratory burst GO:0060263 12 8 1,000 3,834E-04 8,216E-03 ! positive regulation of glucose metabolic process GO:0010907 18 9 1,000 4,917E-04 0,01044625 ! regulation of epidermal growth factor receptor activity GO:0007176 17 9 1,000 4,917E-04 0,0103562 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 20 9 1,000 4,917E-04 0,01026769 ! microtubule bundle formation GO:0001578 22 9 1,000 4,917E-04 0,01018067 ! insulin-like growth factor receptor signaling pathway GO:0048009 22 9 1,000 4,917E-04 0,01009512 ! S phase GO:0051320 10 9 1,000 4,917E-04 0,01001099 GO:0000084|S phase of mitotic cell cycle, ! establishment or maintenance of cell polarity GO:0007163 96 41 2,000 4,92E-04 9,934E-03 ! gliogenesis GO:0042063 91 41 2,000 4,92E-04 9,853E-03 ! regulation of DNA metabolic process GO:0051052 188 97 3,000 4,959E-04 9,85E-03 ! regulation of protein localization GO:0032880 188 97 3,000 4,959E-04 9,771E-03 ! hormone metabolic process GO:0042445 171 100 3,000 5,564E-04 0,01087486 ! regulation of developmental growth GO:0048638 16 10 1,000 6,132E-04 0,01188862 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 21 10 1,000 6,132E-04 0,01179501 ! positive regulation of B cell proliferation GO:0030890 18 10 1,000 6,132E-04 0,01170286 ! positive regulation of survival gene product expression GO:0045885 26 10 1,000 6,132E-04 0,01161214 ! protein heterooligomerization GO:0051291 17 10 1,000 6,132E-04 0,01152282 ! positive regulation of phagocytosis GO:0050766 14 10 1,000 6,132E-04 0,01143486 ! regulation of cellular carbohydrate catabolic process GO:0043471 21 10 1,000 6,132E-04 0,01134823 GO:0043470|regulation of carbohydrate catabolic process, ! induction of apoptosis by intracellular signals GO:0008629 95 45 2,000 6,479E-04 0,01190004 ! G1/S transition of mitotic cell cycle GO:0000082 124 46 2,000 6,912E-04 0,01260085 ! cell growth GO:0016049 90 46 2,000 6,912E-04 0,01250751 ! cortical actin cytoskeleton organization GO:0030866 29 11 1,000 7,476E-04 0,01342912 ! regulation of nitric-oxide synthase activity GO:0050999 28 11 1,000 7,476E-04 0,01333109 ! peptide or protein amino-terminal blocking GO:0018409 22 11 1,000 7,476E-04 0,01323449 ! sequestering of metal ion GO:0051238 15 11 1,000 7,476E-04 0,01313928 ! regulation of embryonic development GO:0045995 35 11 1,000 7,476E-04 0,01304543 ! JAK-STAT cascade GO:0007259 82 48 2,000 7,832E-04 0,01357033 ! positive regulation of cellular catabolic process GO:0031331 34 12 1,000 8,949E-04 0,0153962 ! cortical cytoskeleton organization GO:0030865 30 12 1,000 8,949E-04 0,01528853 ! virus-host interaction GO:0019048 30 12 1,000 8,949E-04 0,01518236 ! regulation of B cell proliferation GO:0030888 22 12 1,000 8,949E-04 0,01507766 ! mitotic spindle organization GO:0007052 23 12 1,000 8,949E-04 0,01497439 ! entry into host cell GO:0030260 34 12 1,000 8,949E-04 0,01487252 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! regulation of phagocytosis GO:0050764 17 12 1,000 8,949E-04 0,01477203 ! cranial nerve development GO:0021545 23 12 1,000 8,949E-04 0,01467289 ! histone acetylation GO:0016573 27 12 1,000 8,949E-04 0,01457507 ! peptidyl-lysine modification GO:0018205 21 12 1,000 8,949E-04 0,01447854 ! localization within membrane GO:0051668 26 12 1,000 8,949E-04 0,01438329 ! regulation of cell projection organization GO:0031344 135 51 2,000 9,353E-04 0,014935 ! cellular carbohydrate catabolic process GO:0044275 17 13 1,000 1,055E-03 0,01673657 ! positive regulation of carbohydrate metabolic process GO:0045913 23 13 1,000 1,055E-03 0,01662859 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! regulation of monooxygenase activity GO:0032768 35 13 1,000 1,055E-03 0,016522 ! regulation of erythrocyte differentiation GO:0045646 47 13 1,000 1,055E-03 0,01641676 ! regulation of angiogenesis GO:0045765 125 54 2,000 1,105E-03 0,01708543 ! regulation of translational initiation GO:0006446 87 54 2,000 1,105E-03 0,01697798 ! response to UV GO:0009411 120 55 2,000 1,166E-03 0,0177967 ! positive regulation of cell migration GO:0030335 137 58 2,000 1,36E-03 0,02063213 ! aging GO:0007568 112 58 2,000 1,36E-03 0,02050477 ! N-terminal protein amino acid modification GO:0031365 30 15 1,000 1,413E-03 0,02118188 ! positive regulation of oxidoreductase activity GO:0051353 22 15 1,000 1,413E-03 0,02105272 ! establishment of organelle localization GO:0051656 122 59 2,000 1,429E-03 0,0211528 ! regulation of glucose metabolic process GO:0010906 28 16 1,000 1,611E-03 0,02371218 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 34 16 1,000 1,611E-03 0,02357019 ! viral reproductive process GO:0022415 132 62 2,000 1,649E-03 0,02397259 ! regulation of protein complex assembly GO:0043254 132 63 2,000 1,726E-03 0,0249543 ! regulation of mitosis GO:0007088 112 63 2,000 1,726E-03 0,02480751 GO:0051783|regulation of nuclear division, ! protein amino acid autophosphorylation GO:0046777 157 64 2,000 1,806E-03 0,02580506 ! regulation of survival gene product expression GO:0045884 38 17 1,000 1,822E-03 0,02587287 ! negative regulation of microtubule depolymerization GO:0007026 50 17 1,000 1,822E-03 0,02572331 GO:0031114|regulation of microtubule depolymerization, ! positive regulation of cell motion GO:0051272 157 65 2,000 1,889E-03 0,02651504 ! regulation of lipid metabolic process GO:0019216 132 66 2,000 1,973E-03 0,02754394 ! centrosome cycle GO:0007098 26 18 1,000 2,044E-03 0,02837586 ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 29 18 1,000 2,044E-03 0,02821555 ! regulation of generation of precursor metabolites and energy GO:0043467 37 18 1,000 2,044E-03 0,02805703 ! nerve development GO:0021675 34 18 1,000 2,044E-03 0,02790029 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 52 18 1,000 2,044E-03 0,02774529 ! myeloid cell differentiation GO:0030099 126 67 2,000 2,06E-03 0,02780352 ! viral reproduction GO:0016032 142 68 2,000 2,149E-03 0,02884842 ! negative regulation of protein kinase activity GO:0006469 144 69 2,000 2,241E-03 0,02991351 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 131 69 2,000 2,241E-03 0,02975093 ! G1 phase of mitotic cell cycle GO:0000080 39 19 1,000 2,279E-03 0,03009755 ! protein export from nucleus GO:0006611 40 19 1,000 2,279E-03 0,02993574 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 30 19 1,000 2,279E-03 0,02977565 ! negative regulation of kinase activity GO:0033673 145 70 2,000 2,335E-03 0,03033918 ! phosphoinositide phosphorylation GO:0046854 40 20 1,000 2,526E-03 0,03265392 ! protein amino acid acetylation GO:0006473 41 20 1,000 2,526E-03 0,03248206 ! regulation of carbohydrate metabolic process GO:0006109 37 20 1,000 2,526E-03 0,032312 GO:0010675|regulation of cellular carbohydrate metabolic process, ! negative regulation of translation GO:0017148 32 20 1,000 2,526E-03 0,0321437 ! negative regulation of transferase activity GO:0051348 155 74 2,000 2,735E-03 0,03461922 ! organelle localization GO:0051640 155 74 2,000 2,735E-03 0,03444077 ! lipid phosphorylation GO:0046834 43 21 1,000 2,785E-03 0,03489517 ! cell aging GO:0007569 48 22 1,000 3,056E-03 0,03809553 ! G1 phase GO:0051318 44 22 1,000 3,056E-03 0,03790215 ! sarcomere organization GO:0045214 32 22 1,000 3,056E-03 0,03771072 ! positive regulation of B cell activation GO:0050871 42 22 1,000 3,056E-03 0,03752122 ! regulation of mitotic metaphase/anaphase transition GO:0030071 44 22 1,000 3,056E-03 0,03733361 ! protein stabilization GO:0050821 41 22 1,000 3,056E-03 0,03714788 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 29 23 1,000 3,339E-03 0,04038545 ! positive regulation of phosphorylation GO:0042327 149 81 2,000 3,532E-03 0,04250548 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 35 24 1,000 3,634E-03 0,04351838 ! positive regulation of cell adhesion GO:0045785 61 24 1,000 3,634E-03 0,0433061 ! regulation of cellular catabolic process GO:0031329 55 24 1,000 3,634E-03 0,04309587 ! calcium-independent cell-cell adhesion GO:0016338 36 24 1,000 3,634E-03 0,04288768 ! positive regulation of epithelial cell proliferation GO:0050679 73 24 1,000 3,634E-03 0,04268149 ! sex determination GO:0007530 48 24 1,000 3,634E-03 0,04247727 ! negative regulation of phosphorylation GO:0042326 52 24 1,000 3,634E-03 0,042275 ! regulation of microtubule polymerization or depolymerization GO:0031110 68 24 1,000 3,634E-03 0,04207464 ! positive regulation of phosphorus metabolic process GO:0010562 156 83 2,000 3,783E-03 0,04359383 GO:0045937|positive regulation of phosphate metabolic process, ! vasculogenesis GO:0001570 49 25 1,000 3,94E-03 0,04519327 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 51 25 1,000 3,94E-03 0,04498209 ! protein tetramerization GO:0051262 57 25 1,000 3,94E-03 0,04477287 ! initiation of viral infection GO:0019059 60 26 1,000 4,258E-03 0,04816154 ! microtubule organizing center organization GO:0031023 42 26 1,000 4,258E-03 0,0479396 GO:0051297|centrosome organization, ! negative regulation of phosphorus metabolic process GO:0010563 56 26 1,000 4,258E-03 0,0477197 GO:0045936|negative regulation of phosphate metabolic process, ! positive regulation of nuclear division GO:0051785 41 26 1,000 4,258E-03 0,0475018 GO:0045840|positive regulation of mitosis, ! regulation of osteoblast differentiation GO:0045667 68 26 1,000 4,258E-03 0,04728588 ! protein amino acid acylation GO:0043543 59 28 1,000 4,929E-03 0,05448144 ! dendrite development GO:0016358 67 28 1,000 4,929E-03 0,05423603 ! fibroblast growth factor receptor signaling pathway GO:0008543 54 29 1,000 5,281E-03 0,05785086 ! somitogenesis GO:0001756 52 29 1,000 5,281E-03 0,05759259 ! negative regulation of neuron differentiation GO:0045665 46 29 1,000 5,281E-03 0,05733663 ! negative regulation of neuron apoptosis GO:0043524 69 29 1,000 5,281E-03 0,05708292 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 58 30 1,000 5,644E-03 0,06074239 ! myofibril assembly GO:0030239 50 30 1,000 5,644E-03 0,06047598 GO:0055002|striated muscle cell development, ! sterol biosynthetic process GO:0016126 56 30 1,000 5,644E-03 0,06021189 ! regulation of B cell activation GO:0050864 55 30 1,000 5,644E-03 0,0599501 ! leukocyte differentiation GO:0002521 232 98 2,000 6,013E-03 0,06359238 ! peptide transport GO:0015833 60 31 1,000 6,019E-03 0,06337729 ! cellular response to extracellular stimulus GO:0031668 52 31 1,000 6,019E-03 0,06310529 ! regulation of microtubule cytoskeleton organization GO:0070507 77 31 1,000 6,019E-03 0,06283561 ! response to heat GO:0009408 54 31 1,000 6,019E-03 0,06256822 ! skeletal muscle tissue development GO:0007519 223 100 2,000 6,358E-03 0,0658187 GO:0060538|skeletal muscle organ development, ! spindle organization GO:0007051 50 32 1,000 6,404E-03 0,06601499 ! muscle cell development GO:0055001 52 32 1,000 6,404E-03 0,06573762 ! peripheral nervous system development GO:0007422 68 32 1,000 6,404E-03 0,06546256 ! positive regulation of catabolic process GO:0009896 72 32 1,000 6,404E-03 0,0651898 ! glial cell differentiation GO:0010001 67 34 1,000 7,208E-03 0,07306965 ! positive regulation of endocytosis GO:0045807 56 35 1,000 7,627E-03 0,07698999 ! calcium-mediated signaling GO:0019722 67 35 1,000 7,627E-03 0,07667316 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 52 36 1,000 8,055E-03 0,08065386 ! antigen processing and presentation of peptide antigen GO:0048002 68 36 1,000 8,055E-03 0,08032466 ! regulation of microtubule-based process GO:0032886 86 37 1,000 8,495E-03 0,08436371 ! actomyosin structure organization GO:0031032 68 37 1,000 8,495E-03 0,08402215 ! cellular component assembly involved in morphogenesis GO:0010927 65 38 1,000 8,945E-03 0,08811758 ! positive regulation of JAK-STAT cascade GO:0046427 55 38 1,000 8,945E-03 0,0877637 ! positive regulation of leukocyte proliferation GO:0070665 70 39 1,000 9,406E-03 0,09191361 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! mismatch repair GO:0006298 58 40 1,000 9,877E-03 0,09613146 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 66 42 1,000 0,01084954 0,10518027 ! positive regulation of transcription factor activity GO:0051091 71 43 1,000 0,01135115 0,10960815 GO:0090047|positive regulation of transcription regulator activity, ! striated muscle cell differentiation GO:0051146 91 43 1,000 0,01135115 0,10917662 ! segmentation GO:0035282 78 43 1,000 0,01135115 0,10874848 ! negative regulation of protein complex disassembly GO:0043242 113 44 1,000 0,01186281 0,11320643 ! regulation of gene-specific transcription GO:0032583 102 46 1,000 0,01291595 0,12277689 ! positive regulation of DNA binding GO:0043388 83 48 1,000 0,01400831 0,1326446 ! regulation of JAK-STAT cascade GO:0046425 76 48 1,000 0,01400831 0,13213246 ! response to calcium ion GO:0051592 94 49 1,000 0,01456901 0,13689261 ! regulation of mast cell proliferation GO:0070666 89 49 1,000 0,01456901 0,13636812 ! regulation of ossification GO:0030278 123 50 1,000 0,01513927 0,14116499 ! viral infectious cycle GO:0019058 104 51 1,000 0,01571902 0,14601354 ! response to temperature stimulus GO:0009266 84 51 1,000 0,01571902 0,14546046 ! positive regulation of binding GO:0051099 88 52 1,000 0,01630818 0,15034298 ! regulation of protein complex disassembly GO:0043244 127 52 1,000 0,01630818 0,14977778 ! histone modification GO:0016570 104 52 1,000 0,01630818 0,14921682 ! positive regulation of growth GO:0045927 96 53 1,000 0,01690668 0,15411576 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 79 53 1,000 0,01690668 0,15354284 ! regulation of leukocyte proliferation GO:0070663 97 53 1,000 0,01690668 0,15297416 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! regulation of neuron apoptosis GO:0043523 117 53 1,000 0,01690668 0,15240968 ! activation of phospholipase C activity GO:0007202 110 54 1,000 0,01751444 0,157308 GO:0010863|positive regulation of phospholipase C activity, ! covalent chromatin modification GO:0016569 115 54 1,000 0,01751444 0,15673178 ! positive regulation of phospholipase activity GO:0010518 111 55 1,000 0,01813138 0,16166042 ! negative regulation of protein ubiquitination GO:0031397 10 5 0,000 0,01857075 0,16497581 ! negative regulation of nucleotide biosynthetic process GO:0030809 11 5 0,000 0,01857075 0,16437807 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! positive regulation of muscle development GO:0048636 15 5 0,000 0,01857075 0,16378465 GO:0045844|positive regulation of striated muscle development, ! positive regulation of interferon-alpha biosynthetic process GO:0045356 7 5 0,000 0,01857075 0,16319549 ! positive regulation of helicase activity GO:0051096 12 5 0,000 0,01857075 0,16261056 ! neuron fate determination GO:0048664 7 5 0,000 0,01857075 0,16202981 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01857075 0,16145319 ! regulation of cGMP biosynthetic process GO:0030826 10 5 0,000 0,01857075 0,16088066 ! hemoglobin biosynthetic process GO:0042541 8 5 0,000 0,01857075 0,16031218 ! polyol transport GO:0015791 12 5 0,000 0,01857075 0,1597477 ! benzene and derivative metabolic process GO:0042537 12 5 0,000 0,01857075 0,15918718 ! response to superoxide GO:0000303 10 5 0,000 0,01857075 0,15863058 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01857075 0,15807786 ! positive regulation of lipid biosynthetic process GO:0046889 11 5 0,000 0,01857075 0,15752898 GO:0045940|positive regulation of steroid metabolic process, ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 10 5 0,000 0,01857075 0,1569839 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! tongue development GO:0043586 8 5 0,000 0,01857075 0,15644257 ! female meiosis GO:0007143 10 5 0,000 0,01857075 0,15590497 ! cell adhesion mediated by integrin GO:0033627 10 5 0,000 0,01857075 0,15537105 ! phenylalanyl-tRNA aminoacylation GO:0006432 7 5 0,000 0,01857075 0,15484077 ! hypothalamus development GO:0021854 9 5 0,000 0,01857075 0,1543141 ! phosphatidic acid metabolic process GO:0046473 6 5 0,000 0,01857075 0,15379101 ! cobalt ion transport GO:0006824 11 5 0,000 0,01857075 0,15327144 ! cellular sodium ion homeostasis GO:0006883 11 5 0,000 0,01857075 0,15275538 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 16 5 0,000 0,01857075 0,15224277 ! nuclear mRNA 3'-splice site recognition GO:0000389 7 5 0,000 0,01857075 0,1517336 ! regulation of cardiac muscle cell proliferation GO:0060043 9 5 0,000 0,01857075 0,15122782 ! embryonic camera-type eye development GO:0031076 12 5 0,000 0,01857075 0,1507254 GO:0048596|embryonic camera-type eye morphogenesis, ! selenocysteine incorporation GO:0001514 12 5 0,000 0,01857075 0,15022631 GO:0006451|translational readthrough, ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01857075 0,14973052 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 7 5 0,000 0,01857075 0,14923798 ! transposition GO:0032196 9 5 0,000 0,01857075 0,14874868 ! 2-oxoglutarate metabolic process GO:0006103 10 5 0,000 0,01857075 0,14826257 ! regulation of mitochondrial membrane permeability GO:0046902 15 5 0,000 0,01857075 0,14777963 ! negative chemotaxis GO:0050919 16 5 0,000 0,01857075 0,14729983 ! positive regulation of histone modification GO:0031058 6 5 0,000 0,01857075 0,14682313 ! transcription from mitochondrial promoter GO:0006390 7 5 0,000 0,01857075 0,14634951 ! negative regulation of receptor-mediated endocytosis GO:0048261 6 5 0,000 0,01857075 0,14587893 ! behavioral response to pain GO:0048266 10 5 0,000 0,01857075 0,14541137 ! clathrin coat assembly GO:0048268 15 5 0,000 0,01857075 0,14494679 ! Notch receptor processing GO:0007220 11 5 0,000 0,01857075 0,14448518 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01857075 0,1440265 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! metabotropic glutamate receptor signaling pathway GO:0007216 7 5 0,000 0,01857075 0,14357072 ! micturition GO:0060073 9 5 0,000 0,01857075 0,14311781 ! serotonin receptor signaling pathway GO:0007210 10 5 0,000 0,01857075 0,14266776 ! copulation GO:0007620 9 5 0,000 0,01857075 0,14222052 ! glial cell fate commitment GO:0021781 14 5 0,000 0,01857075 0,14177608 ! bioluminescence GO:0008218 9 5 0,000 0,01857075 0,14133441 ! spermidine metabolic process GO:0008216 7 5 0,000 0,01857075 0,14089549 ! regulation of potassium ion transport GO:0043266 10 5 0,000 0,01857075 0,14045928 ! cell migration involved in gastrulation GO:0042074 7 5 0,000 0,01857075 0,14002576 ! apoptotic cell clearance GO:0043277 23 5 0,000 0,01857075 0,13959491 ! positive regulation of muscle cell differentiation GO:0051149 13 5 0,000 0,01857075 0,13916671 ! smooth muscle cell differentiation GO:0051145 8 5 0,000 0,01857075 0,13874112 ! lipoprotein particle clearance GO:0034381 10 5 0,000 0,01857075 0,13831813 ! grooming behavior GO:0007625 6 5 0,000 0,01857075 0,13789771 ! detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 6 5 0,000 0,01857075 0,13747984 ! fructose 1,6-bisphosphate metabolic process GO:0030388 7 5 0,000 0,01857075 0,13706449 ! regulation of odontogenesis of dentine-containing tooth GO:0042487 12 5 0,000 0,01857075 0,13665165 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01857075 0,13624128 ! response to protozoan GO:0001562 13 5 0,000 0,01857075 0,13583337 ! lymph vessel development GO:0001945 10 5 0,000 0,01857075 0,1354279 ! regulation of activin receptor signaling pathway GO:0032925 15 5 0,000 0,01857075 0,13502484 ! endochondral ossification GO:0001958 17 5 0,000 0,01857075 0,13462417 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 11 5 0,000 0,01857075 0,13422588 ! single strand break repair GO:0000012 8 5 0,000 0,01857075 0,13382993 ! parathyroid gland development GO:0060017 14 5 0,000 0,01857075 0,13343631 ! anagen GO:0042640 7 5 0,000 0,01857075 0,13304501 ! deoxyribonucleoside triphosphate metabolic process GO:0009200 6 5 0,000 0,01857075 0,13265598 ! positive regulation of viral genome replication GO:0045070 9 5 0,000 0,01857075 0,13226923 ! cytokine secretion GO:0050663 15 5 0,000 0,01857075 0,13188473 ! hydrogen peroxide biosynthetic process GO:0050665 8 5 0,000 0,01857075 0,13150245 ! ceramide catabolic process GO:0046514 7 5 0,000 0,01857075 0,13112239 ! skeletal myofibril assembly GO:0014866 12 5 0,000 0,01857075 0,13074452 ! smooth muscle tissue development GO:0048745 32 5 0,000 0,01857075 0,13036881 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 7 5 0,000 0,01857075 0,12999526 ! peptidyl-lysine modification to hypusine GO:0008612 10 5 0,000 0,01857075 0,12962385 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 9 5 0,000 0,01857075 0,12925455 ! cardiac muscle fiber development GO:0048739 12 5 0,000 0,01857075 0,12888735 ! thiamin diphosphate biosynthetic process GO:0009229 5 5 0,000 0,01857075 0,12852223 GO:0042724|thiamin and derivative biosynthetic process, GO:0042357|thiamin diphosphate metabolic process, ! negative regulation of survival gene product expression GO:0008634 9 5 0,000 0,01857075 0,12815917 ! neutrophil mediated immunity GO:0002446 7 5 0,000 0,01857075 0,12779816 ! cellular di-, tri-valent inorganic anion homeostasis GO:0030319 10 5 0,000 0,01857075 0,12743918 GO:0030643|cellular phosphate ion homeostasis, GO:0055062|phosphate ion homeostasis, GO:0055061|di-, tri-valent inorganic anion homeostasis, ! negative regulation of oligodendrocyte differentiation GO:0048715 15 5 0,000 0,01857075 0,1270822 ! negative regulation of RNA splicing GO:0033119 6 5 0,000 0,01857075 0,12672723 ! glycine biosynthetic process GO:0006545 7 5 0,000 0,01857075 0,12637422 ! valine metabolic process GO:0006573 12 5 0,000 0,01857075 0,12602319 ! endoplasmic reticulum organization GO:0007029 12 5 0,000 0,01857075 0,12567409 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 16 5 0,000 0,01857075 0,12532692 ! assembly of spliceosomal tri-snRNP GO:0000244 8 5 0,000 0,01857075 0,12498167 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 7 5 0,000 0,01857075 0,12463832 ! immunoglobulin V(D)J recombination GO:0033152 25 5 0,000 0,01857075 0,12429684 ! polyol catabolic process GO:0046174 9 5 0,000 0,01857075 0,12395723 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 6 5 0,000 0,01857075 0,12361947 ! melanin biosynthetic process from tyrosine GO:0006583 8 5 0,000 0,01857075 0,12328355 ! regulation of cardiac muscle contraction GO:0055117 6 5 0,000 0,01857075 0,12294945 ! muscle cell migration GO:0014812 8 5 0,000 0,01857075 0,12261715 ! mitochondrial fission GO:0000266 8 5 0,000 0,01857075 0,12228665 ! response to tumor necrosis factor GO:0034612 10 5 0,000 0,01857075 0,12195792 ! mRNA transcription GO:0009299 10 5 0,000 0,01857075 0,12163096 ! nerve growth factor processing GO:0032455 9 5 0,000 0,01857075 0,12130574 ! positive regulation of filopodium assembly GO:0051491 16 5 0,000 0,01857075 0,12098226 GO:0051489|regulation of filopodium assembly, ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 8 5 0,000 0,01857075 0,1206605 ! anaerobic glycolysis GO:0019642 6 5 0,000 0,01857075 0,12034044 ! monocyte activation GO:0042117 10 5 0,000 0,01857075 0,12002208 ! regulation of angiotensin levels in blood GO:0002002 9 5 0,000 0,01857075 0,1197054 GO:0060177|regulation of angiotensin metabolic process, ! regulation of response to food GO:0032095 7 5 0,000 0,01857075 0,11939039 ! response to food GO:0032094 6 5 0,000 0,01857075 0,11907703 ! morphogenesis of an epithelial sheet GO:0002011 11 5 0,000 0,01857075 0,11876531 ! positive regulation of transporter activity GO:0032411 8 5 0,000 0,01857075 0,11845521 GO:0032414|positive regulation of ion transmembrane transporter activity, ! regulation of glycogen metabolic process GO:0070873 10 5 0,000 0,01857075 0,11814674 GO:0032881|regulation of polysaccharide metabolic process, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01857075 0,11783986 ! forebrain neuron development GO:0021884 13 5 0,000 0,01857075 0,11753458 ! lipoprotein catabolic process GO:0042159 11 5 0,000 0,01857075 0,11723087 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 10 5 0,000 0,01857075 0,11692873 ! virus-infected cell apoptosis GO:0006926 7 5 0,000 0,01857075 0,11662814 ! substrate-bound cell migration, cell extension GO:0006930 6 5 0,000 0,01857075 0,11632909 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01857075 0,11603158 GO:0009251|glucan catabolic process, ! entrainment of circadian clock GO:0009649 12 5 0,000 0,01857075 0,11573558 ! peptidyl-threonine phosphorylation GO:0018107 20 5 0,000 0,01857075 0,11544109 ! peptidyl-histidine phosphorylation GO:0018106 10 5 0,000 0,01857075 0,11514809 ! lipid glycosylation GO:0030259 7 5 0,000 0,01857075 0,11485657 ! nucleobase transport GO:0015851 6 5 0,000 0,01857075 0,11456653 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01857075 0,11427795 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! establishment of synaptic specificity at neuromuscular junction GO:0007529 8 5 0,000 0,01857075 0,11399082 ! positive regulation of vasoconstriction GO:0045907 10 5 0,000 0,01857075 0,11370513 ! positive regulation of fatty acid metabolic process GO:0045923 14 5 0,000 0,01857075 0,11342087 ! basic amino acid transport GO:0015802 12 5 0,000 0,01857075 0,11313802 ! cellular glucose homeostasis GO:0001678 6 5 0,000 0,01857075 0,11285658 ! heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 13 5 0,000 0,01857075 0,11257654 ! actin nucleation GO:0045010 11 5 0,000 0,01857075 0,11229789 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01857075 0,11202061 ! depurination GO:0045007 5 5 0,000 0,01857075 0,1117447 ! depyrimidination GO:0045008 10 5 0,000 0,01857075 0,11147014 ! regulation of synaptic growth at neuromuscular junction GO:0008582 9 5 0,000 0,01857075 0,11119693 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01857075 0,11092505 ! G2/M transition checkpoint GO:0031576 8 5 0,000 0,01857075 0,1106545 GO:0031572|G2/M transition DNA damage checkpoint, ! homeostasis of number of cells within a tissue GO:0048873 12 5 0,000 0,01857075 0,11038527 ! zinc ion homeostasis GO:0055069 9 5 0,000 0,01857075 0,11011735 GO:0006882|cellular zinc ion homeostasis, ! meiotic chromosome segregation GO:0045132 10 5 0,000 0,01857075 0,10985072 ! nucleoside monophosphate catabolic process GO:0009125 14 5 0,000 0,01857075 0,10958538 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01857075 0,10932132 ! leukemia inhibitory factor signaling pathway GO:0048861 14 5 0,000 0,01857075 0,10905853 ! activated T cell proliferation GO:0050798 16 5 0,000 0,01857075 0,10879699 ! negative regulation of alpha-beta T cell activation GO:0046636 10 5 0,000 0,01857075 0,10853671 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 11 5 0,000 0,01857075 0,10827768 ! DNA damage response, detection of DNA damage GO:0042769 5 5 0,000 0,01857075 0,10801987 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01857075 0,10776329 ! gamma-delta T cell activation GO:0046629 6 5 0,000 0,01857075 0,10750793 ! response to arsenic GO:0046685 11 5 0,000 0,01857075 0,10725377 ! negative regulation of T cell mediated immunity GO:0002710 15 5 0,000 0,01857075 0,10700082 GO:0002707|negative regulation of lymphocyte mediated immunity, ! mast cell degranulation GO:0043303 7 5 0,000 0,01857075 0,10674905 GO:0002448|mast cell mediated immunity, ! regulation of leukocyte degranulation GO:0043300 8 5 0,000 0,01857075 0,10649847 ! L-ascorbic acid metabolic process GO:0019852 10 5 0,000 0,01857075 0,10624906 ! base-excision repair, DNA ligation GO:0006288 6 5 0,000 0,01857075 0,10600081 ! response to mercury ion GO:0046689 8 5 0,000 0,01857075 0,10575372 ! response to cadmium ion GO:0046686 7 5 0,000 0,01857075 0,10550778 ! tetrahydrofolate metabolic process GO:0046653 7 5 0,000 0,01857075 0,10526299 ! UDP-N-acetylgalactosamine metabolic process GO:0019276 5 5 0,000 0,01857075 0,10501932 ! DNA replication, synthesis of RNA primer GO:0006269 8 5 0,000 0,01857075 0,10477678 ! bile acid biosynthetic process GO:0006699 7 5 0,000 0,01857075 0,10453536 ! sphingomyelin catabolic process GO:0006685 7 5 0,000 0,01857075 0,10429505 ! ganglioside catabolic process GO:0006689 12 5 0,000 0,01857075 0,10405584 ! glucosylceramide metabolic process GO:0006678 6 5 0,000 0,01857075 0,10381773 ! decidualization GO:0046697 11 5 0,000 0,01857075 0,1035807 ! platelet activating factor biosynthetic process GO:0006663 7 5 0,000 0,01857075 0,10334475 ! positive regulation of interleukin-4 production GO:0032753 9 5 0,000 0,01857075 0,10310988 GO:0032754|positive regulation of interleukin-5 production, ! protein autoprocessing GO:0016540 8 5 0,000 0,01857075 0,10287607 ! regulation of chondrocyte differentiation GO:0032330 16 5 0,000 0,01857075 0,10264332 ! embryonic cleavage GO:0040016 6 5 0,000 0,01857075 0,10241162 ! peroxisome fission GO:0016559 5 5 0,000 0,01857075 0,10218096 ! histone demethylation GO:0016577 13 5 0,000 0,01857075 0,10195134 ! reproductive behavior in a multicellular organism GO:0033057 17 5 0,000 0,01857075 0,10172275 ! mitotic recombination GO:0006312 9 5 0,000 0,01857075 0,10149518 ! spinal cord association neuron differentiation GO:0021527 9 5 0,000 0,01857075 0,10126863 ! negative regulation of interleukin-6 production GO:0032715 5 5 0,000 0,01857075 0,10104309 ! metaphase plate congression GO:0051310 7 5 0,000 0,01857075 0,10081855 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01857075 0,100595 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 8 5 0,000 0,01857075 0,10037245 ! enteric nervous system development GO:0048484 8 5 0,000 0,01857075 0,10015088 ! indolalkylamine catabolic process GO:0046218 8 5 0,000 0,01857075 0,09993028 GO:0006569|tryptophan catabolic process, GO:0042436|indole derivative catabolic process, ! lymphocyte costimulation GO:0031294 8 5 0,000 0,01857075 0,09971065 GO:0031295|T cell costimulation, ! positive regulation of mast cell activation GO:0033005 12 5 0,000 0,01857075 0,09949199 ! muscle cell proliferation GO:0033002 12 5 0,000 0,01857075 0,09927428 ! skeletal muscle regeneration GO:0043403 8 5 0,000 0,01857075 0,09905753 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 16 5 0,000 0,01857075 0,09884171 ! B cell homeostasis GO:0001782 13 5 0,000 0,01857075 0,09862684 ! positive regulation of Wnt receptor signaling pathway GO:0030177 13 5 0,000 0,01857075 0,0984129 ! coenzyme A biosynthetic process GO:0015937 7 5 0,000 0,01857075 0,09819988 ! metaphase GO:0051323 11 5 0,000 0,01857075 0,09798779 ! melatonin biosynthetic process GO:0030187 7 5 0,000 0,01857075 0,09777661 GO:0030186|melatonin metabolic process, ! positive regulation of blood coagulation GO:0030194 12 5 0,000 0,01857075 0,09756634 ! cellular response to nutrient GO:0031670 8 5 0,000 0,01857075 0,09735697 ! positive regulation of macrophage activation GO:0043032 12 5 0,000 0,01857075 0,09714849 ! regulation of muscle cell apoptosis GO:0010660 7 5 0,000 0,01857075 0,09694091 ! ATP-dependent chromatin remodeling GO:0043044 10 5 0,000 0,01857075 0,09673421 ! regulation of hair follicle development GO:0051797 10 5 0,000 0,01857075 0,0965284 GO:0042634|regulation of hair cycle, ! definitive hemopoiesis GO:0060216 14 5 0,000 0,01857075 0,09632345 ! response to redox state GO:0051775 6 5 0,000 0,01857075 0,09611938 GO:0006980|redox signal response, ! negative regulation of macrophage differentiation GO:0045650 7 5 0,000 0,01857075 0,09591617 ! glucocorticoid biosynthetic process GO:0006704 7 5 0,000 0,01857075 0,09571381 ! regulation of keratinocyte differentiation GO:0045616 6 5 0,000 0,01857075 0,09551231 ! brown fat cell differentiation GO:0050873 7 5 0,000 0,01857075 0,09531165 ! regulation of telomerase activity GO:0051972 7 5 0,000 0,01857075 0,09511184 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01857075 0,09491286 GO:0006681|galactosylceramide metabolic process, ! secretory granule organization GO:0033363 15 5 0,000 0,01857075 0,09471471 ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01857075 0,09451739 GO:0033015|tetrapyrrole catabolic process, ! circadian behavior GO:0048512 15 5 0,000 0,01857075 0,09432089 ! striatum development GO:0021756 14 5 0,000 0,01857075 0,0941252 ! positive regulation of T cell mediated cytotoxicity GO:0001916 15 5 0,000 0,01857075 0,09393032 ! triglyceride biosynthetic process GO:0019432 7 5 0,000 0,01857075 0,09373625 ! glial cell migration GO:0008347 10 5 0,000 0,01857075 0,09354298 ! inner cell mass cell proliferation GO:0001833 5 5 0,000 0,01857075 0,09335051 ! neural plate morphogenesis GO:0001839 7 5 0,000 0,01857075 0,09315882 ! regulation of mitochondrial depolarization GO:0051900 14 5 0,000 0,01857075 0,09296792 ! somatic stem cell maintenance GO:0035019 15 5 0,000 0,01857075 0,09277781 ! T cell activation during immune response GO:0002286 9 5 0,000 0,01857075 0,09258846 ! negative regulation of fibrinolysis GO:0051918 11 5 0,000 0,01857075 0,09239989 ! negative regulation of lipase activity GO:0060192 8 5 0,000 0,01857075 0,09221209 ! innate immune response activating cell surface receptor signaling pathway GO:0002220 7 5 0,000 0,01857075 0,09202504 ! neuroprotection GO:0043526 8 5 0,000 0,01857075 0,09183876 ! positive regulation of blood vessel endothelial cell migration GO:0043536 16 5 0,000 0,01857075 0,09165323 ! regulation of sensory perception GO:0051931 8 5 0,000 0,01857075 0,09146844 GO:0051930|regulation of sensory perception of pain, ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 10 5 0,000 0,01857075 0,0912844 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 14 5 0,000 0,01857075 0,0911011 ! positive regulation of actin filament bundle formation GO:0032233 18 5 0,000 0,01857075 0,09091853 ! negative regulation of actin filament bundle formation GO:0032232 17 5 0,000 0,01857075 0,09073669 GO:0051497|negative regulation of stress fiber formation, ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 17 5 0,000 0,01857075 0,09055558 ! diacylglycerol metabolic process GO:0046339 7 5 0,000 0,01857075 0,09037519 ! release of sequestered calcium ion into cytosol GO:0051209 14 5 0,000 0,01857075 0,09019552 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! inner ear receptor stereocilium organization GO:0060122 12 5 0,000 0,01857075 0,09001656 GO:0060119|inner ear receptor cell development, ! retrograde protein transport, ER to cytosol GO:0030970 8 5 0,000 0,01857075 0,08983831 ! spindle assembly GO:0051225 6 5 0,000 0,01857075 0,08966076 ! ensheathment of axons in the peripheral nervous system GO:0032292 14 5 0,000 0,01857075 0,08948392 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 7 5 0,000 0,01857075 0,08930777 ! protein palmitoylation GO:0018345 12 5 0,000 0,01857075 0,08913231 ! drug metabolic process GO:0017144 7 5 0,000 0,01857075 0,08895754 ! stem cell division GO:0017145 11 5 0,000 0,01857075 0,08878346 GO:0048103|somatic stem cell division, ! phospholipid scrambling GO:0017121 8 5 0,000 0,01857075 0,08861005 ! organ regeneration GO:0031100 7 5 0,000 0,01857075 0,08843732 ! carnitine metabolic process GO:0009437 8 5 0,000 0,01857075 0,08826527 GO:0006577|betaine metabolic process, ! regulation of liquid surface tension GO:0050828 10 5 0,000 0,01857075 0,08809388 ! negative regulation of cytoskeleton organization GO:0051494 139 56 1,000 0,01875742 0,08880694 ! regulation of bone remodeling GO:0046850 143 57 1,000 0,0193925 0,09163611 ! regulation of phospholipase activity GO:0010517 113 57 1,000 0,0193925 0,0914592 ! heart morphogenesis GO:0003007 105 57 1,000 0,0193925 0,09128298 ! regulation of tissue remodeling GO:0034103 146 58 1,000 0,02003652 0,09413313 ! positive regulation of organelle organization GO:0010638 108 58 1,000 0,02003652 0,09395245 ! positive regulation of lipase activity GO:0060193 115 58 1,000 0,02003652 0,09377247 ! maintenance of location GO:0051235 124 58 1,000 0,02003652 0,09359317 ! nuclear export GO:0051168 110 59 1,000 0,02068943 0,09645855 ! regulation of endocytosis GO:0030100 104 60 1,000 0,02135114 0,09935399 ! cytokine-mediated signaling pathway GO:0019221 112 61 1,000 0,02202159 0,10227897 ! regulation of interferon-alpha biosynthetic process GO:0045354 8 6 0,000 0,02224362 0,10311417 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 7 6 0,000 0,02224362 0,10291887 ! negative regulation of S phase of mitotic cell cycle GO:0045749 12 6 0,000 0,02224362 0,10272432 ! positive regulation of cAMP biosynthetic process GO:0030819 13 6 0,000 0,02224362 0,1025305 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 9 6 0,000 0,02224362 0,10233741 ! oligosaccharide biosynthetic process GO:0009312 11 6 0,000 0,02224362 0,10214505 ! regulation of cGMP metabolic process GO:0030823 12 6 0,000 0,02224362 0,10195341 ! positive regulation of actin filament polymerization GO:0030838 11 6 0,000 0,02224362 0,10176248 ! post-embryonic morphogenesis GO:0009886 9 6 0,000 0,02224362 0,10157227 ! response to oxygen radical GO:0000305 11 6 0,000 0,02224362 0,10138277 ! positive regulation of axon extension GO:0045773 13 6 0,000 0,02224362 0,10119398 ! myoblast cell fate commitment GO:0048625 18 6 0,000 0,02224362 0,10100588 ! negative regulation of small GTPase mediated signal transduction GO:0051058 19 6 0,000 0,02224362 0,10081849 GO:0046580|negative regulation of Ras protein signal transduction, ! pyrimidine nucleotide-sugar transport GO:0015781 10 6 0,000 0,02224362 0,10063179 ! regulation of interferon-beta production GO:0032648 8 6 0,000 0,02224362 0,10044578 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 10 6 0,000 0,02224362 0,10026045 ! virion attachment to host cell surface receptor GO:0019062 16 6 0,000 0,02224362 0,10007581 ! forebrain regionalization GO:0021871 9 6 0,000 0,02224362 0,09989185 ! DNA catabolic process, exonucleolytic GO:0000738 8 6 0,000 0,02224362 0,09970856 ! short-chain fatty acid metabolic process GO:0046459 8 6 0,000 0,02224362 0,09952594 ! regulation of alternative nuclear mRNA splicing, via spliceosome GO:0000381 12 6 0,000 0,02224362 0,099344 ! transforming growth factor beta receptor complex assembly GO:0007181 7 6 0,000 0,02224362 0,09916271 ! regulation of respiratory gaseous exchange GO:0043576 9 6 0,000 0,02224362 0,09898209 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 8 6 0,000 0,02224362 0,09880212 ! negative regulation of cell-cell adhesion GO:0022408 13 6 0,000 0,02224362 0,09862281 ! positive regulation of cell-cell adhesion GO:0022409 15 6 0,000 0,02224362 0,09844414 ! neurofilament cytoskeleton organization GO:0060052 12 6 0,000 0,02224362 0,09826612 ! malate metabolic process GO:0006108 13 6 0,000 0,02224362 0,09808875 ! detection of chemical stimulus involved in sensory perception of taste GO:0050912 7 6 0,000 0,02224362 0,09791201 GO:0050907|detection of chemical stimulus involved in sensory perception, ! sensory perception of bitter taste GO:0050913 9 6 0,000 0,02224362 0,09773591 ! posttranscriptional gene silencing by RNA GO:0035194 20 6 0,000 0,02224362 0,09756044 GO:0016441|posttranscriptional gene silencing, ! phototransduction, visible light GO:0007603 10 6 0,000 0,02224362 0,0973856 ! protein refolding GO:0042026 15 6 0,000 0,02224362 0,09721139 ! cerebral cortex radially oriented cell migration GO:0021799 11 6 0,000 0,02224362 0,0970378 ! opsonization GO:0008228 8 6 0,000 0,02224362 0,09686482 ! mating behavior GO:0007617 7 6 0,000 0,02224362 0,09669247 ! erythrocyte maturation GO:0043249 8 6 0,000 0,02224362 0,09652072 ! embryonic hemopoiesis GO:0035162 16 6 0,000 0,02224362 0,09634958 ! protein amino acid dealkylation GO:0008214 15 6 0,000 0,02224362 0,09617905 GO:0006482|protein amino acid demethylation, ! photoreceptor cell development GO:0042461 10 6 0,000 0,02224362 0,09600913 GO:0046530|photoreceptor cell differentiation, ! regulation of smooth muscle cell differentiation GO:0051150 12 6 0,000 0,02224362 0,0958398 ! ovulation from ovarian follicle GO:0001542 8 6 0,000 0,02224362 0,09567107 ! response to interferon-gamma GO:0034341 16 6 0,000 0,02224362 0,09550293 ! toxin metabolic process GO:0009404 11 6 0,000 0,02224362 0,09533538 ! regulation of interleukin-12 biosynthetic process GO:0045075 7 6 0,000 0,02224362 0,09516842 ! traversing start control point of mitotic cell cycle GO:0007089 14 6 0,000 0,02224362 0,09500204 ! spinal cord dorsal/ventral patterning GO:0021513 13 6 0,000 0,02224362 0,09483624 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 13 6 0,000 0,02224362 0,09467102 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, ! cGMP-mediated signaling GO:0019934 14 6 0,000 0,02224362 0,09450637 ! dorsal spinal cord development GO:0021516 10 6 0,000 0,02224362 0,0943423 ! activation of MAPKKK activity GO:0000185 12 6 0,000 0,02224362 0,0941788 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 15 6 0,000 0,02224362 0,09401586 ! thymic T cell selection GO:0045061 16 6 0,000 0,02224362 0,09385348 ! sphingoid catabolic process GO:0046521 8 6 0,000 0,02224362 0,09369166 ! protein lipoylation GO:0009249 10 6 0,000 0,02224362 0,09353041 ! transepithelial chloride transport GO:0030321 12 6 0,000 0,02224362 0,0933697 GO:0070633|transepithelial transport, ! regulation of retroviral genome replication GO:0045091 8 6 0,000 0,02224362 0,09320955 ! regulation of oligodendrocyte differentiation GO:0048713 16 6 0,000 0,02224362 0,09304994 ! regulation of isotype switching to IgG isotypes GO:0048302 11 6 0,000 0,02224362 0,09289088 ! glutamate catabolic process GO:0006538 12 6 0,000 0,02224362 0,09273236 ! mitochondrial respiratory chain complex assembly GO:0033108 11 6 0,000 0,02224362 0,09257439 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 10 6 0,000 0,02224362 0,09241695 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! positive regulation of peptidyl-serine phosphorylation GO:0033138 12 6 0,000 0,02224362 0,09226004 GO:0033135|regulation of peptidyl-serine phosphorylation, ! response to pH GO:0009268 10 6 0,000 0,02224362 0,09210367 ! hyperosmotic response GO:0006972 10 6 0,000 0,02224362 0,09194783 ! L-serine biosynthetic process GO:0006564 7 6 0,000 0,02224362 0,09179251 ! chromatin-mediated maintenance of transcription GO:0048096 17 6 0,000 0,02224362 0,09163772 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 11 6 0,000 0,02224362 0,09148344 ! vascular smooth muscle contraction GO:0014829 13 6 0,000 0,02224362 0,09132969 ! urea metabolic process GO:0019627 7 6 0,000 0,02224362 0,09117645 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 7 6 0,000 0,02224362 0,09102373 ! neutrophil activation GO:0042119 7 6 0,000 0,02224362 0,09087151 ! positive regulation of muscle hypertrophy GO:0014742 10 6 0,000 0,02224362 0,09071981 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! regulation of appetite GO:0032098 10 6 0,000 0,02224362 0,09056861 ! cerebral cortex GABAergic interneuron differentiation GO:0021892 11 6 0,000 0,02224362 0,09041791 ! paraxial mesoderm development GO:0048339 16 6 0,000 0,02224362 0,09026772 ! positive regulation of multicellular organismal metabolic process GO:0044253 8 6 0,000 0,02224362 0,09011802 ! positive regulation of neuroblast proliferation GO:0002052 13 6 0,000 0,02224362 0,08996882 ! neuron apoptosis GO:0051402 15 6 0,000 0,02224362 0,08982011 ! positive regulation of nitric-oxide synthase activity GO:0051000 11 6 0,000 0,02224362 0,08967189 ! T cell mediated immunity GO:0002456 17 6 0,000 0,02224362 0,08952416 ! negative regulation of platelet activation GO:0010544 9 6 0,000 0,02224362 0,08937692 GO:0010543|regulation of platelet activation, ! folic acid transport GO:0015884 14 6 0,000 0,02224362 0,08923016 ! carnitine transport GO:0015879 10 6 0,000 0,02224362 0,08908388 GO:0015838|betaine transport, ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02224362 0,08893808 ! positive regulation of exocytosis GO:0045921 11 6 0,000 0,02224362 0,08879275 ! protein import into mitochondrial inner membrane GO:0045039 9 6 0,000 0,02224362 0,0886479 ! early endosome to late endosome transport GO:0045022 16 6 0,000 0,02224362 0,08850353 ! 5S class rRNA transcription GO:0042791 13 6 0,000 0,02224362 0,08835962 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! DNA damage response, signal transduction resulting in transcription GO:0042772 19 6 0,000 0,02224362 0,08821618 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! neuronal ion channel clustering GO:0045161 15 6 0,000 0,02224362 0,0880732 ! regulation of collagen metabolic process GO:0010712 10 6 0,000 0,02224362 0,08793069 ! sodium ion homeostasis GO:0055078 12 6 0,000 0,02224362 0,08778864 ! establishment of spindle localization GO:0051293 16 6 0,000 0,02224362 0,08764704 GO:0051653|spindle localization, ! deoxyribonucleoside metabolic process GO:0009120 11 6 0,000 0,02224362 0,0875059 ! negative regulation of gliogenesis GO:0014014 18 6 0,000 0,02224362 0,08736522 GO:0045686|negative regulation of glial cell differentiation, ! neural nucleus development GO:0048857 19 6 0,000 0,02224362 0,08722498 ! response to UV-C GO:0010225 14 6 0,000 0,02224362 0,0870852 ! astrocyte development GO:0014002 16 6 0,000 0,02224362 0,08694586 ! protein targeting to lysosome GO:0006622 12 6 0,000 0,02224362 0,08680697 ! purine base biosynthetic process GO:0009113 17 6 0,000 0,02224362 0,08666853 ! interaction with symbiont GO:0051702 14 6 0,000 0,02224362 0,08653052 ! regulation of dendrite development GO:0050773 16 6 0,000 0,02224362 0,08639295 ! peptidyl-arginine modification GO:0018195 13 6 0,000 0,02224362 0,08625582 ! positive regulation of cytokine production during immune response GO:0002720 11 6 0,000 0,02224362 0,08611912 ! response to copper ion GO:0046688 10 6 0,000 0,02224362 0,08598286 ! response to exogenous dsRNA GO:0043330 13 6 0,000 0,02224362 0,08584702 ! enucleate erythrocyte differentiation GO:0043353 14 6 0,000 0,02224362 0,08571162 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02224362 0,08557664 ! regulation of interleukin-5 production GO:0032674 10 6 0,000 0,02224362 0,08544208 ! positive regulation of B cell differentiation GO:0045579 13 6 0,000 0,02224362 0,08530795 ! regulation of dopamine secretion GO:0014059 14 6 0,000 0,02224362 0,08517424 ! nucleoside catabolic process GO:0009164 10 6 0,000 0,02224362 0,08504095 ! hair follicle maturation GO:0048820 8 6 0,000 0,02224362 0,08490807 ! negative regulation of T cell differentiation GO:0045581 14 6 0,000 0,02224362 0,08477561 ! Schwann cell development GO:0014044 15 6 0,000 0,02224362 0,08464356 ! CD4-positive, alpha beta T cell differentiation GO:0043367 11 6 0,000 0,02224362 0,08451192 ! response to pheromone GO:0019236 6 6 0,000 0,02224362 0,08438069 ! purine deoxyribonucleotide catabolic process GO:0009155 6 6 0,000 0,02224362 0,08424987 ! regulation of interleukin-13 production GO:0032656 12 6 0,000 0,02224362 0,08411945 ! regulation of myeloid cell apoptosis GO:0033032 14 6 0,000 0,02224362 0,08398944 ! base conversion or substitution editing GO:0016553 6 6 0,000 0,02224362 0,08385982 ! subpallium development GO:0021544 15 6 0,000 0,02224362 0,08373061 ! neural tube patterning GO:0021532 8 6 0,000 0,02224362 0,08360179 ! negative regulation of multicellular organism growth GO:0040015 9 6 0,000 0,02224362 0,08347337 ! regulation of myeloid leukocyte mediated immunity GO:0002886 9 6 0,000 0,02224362 0,08334535 ! maintenance of organ identity GO:0048496 9 6 0,000 0,02224362 0,08321771 ! G2 phase GO:0051319 16 6 0,000 0,02224362 0,08309047 GO:0000085|G2 phase of mitotic cell cycle, ! indolalkylamine biosynthetic process GO:0046219 8 6 0,000 0,02224362 0,08296361 GO:0042435|indole derivative biosynthetic process, ! tetracycline transport GO:0015904 8 6 0,000 0,02224362 0,08283714 ! oxygen homeostasis GO:0032364 10 6 0,000 0,02224362 0,08271106 ! establishment of planar polarity GO:0001736 7 6 0,000 0,02224362 0,08258536 ! regulation of mast cell activation GO:0033003 13 6 0,000 0,02224362 0,08246004 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 12 6 0,000 0,02224362 0,0823351 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 10 6 0,000 0,02224362 0,08221054 ! negative regulation of oxidoreductase activity GO:0051354 11 6 0,000 0,02224362 0,08208635 ! receptor internalization GO:0031623 11 6 0,000 0,02224362 0,08196254 ! plasminogen activation GO:0031639 9 6 0,000 0,02224362 0,0818391 ! neutrophil homeostasis GO:0001780 11 6 0,000 0,02224362 0,08171604 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02224362 0,08159334 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 14 6 0,000 0,02224362 0,08147101 ! protein deubiquitination GO:0016579 16 6 0,000 0,02224362 0,08134905 ! negative regulation of neuroblast proliferation GO:0007406 25 6 0,000 0,02224362 0,08122745 ! protein destabilization GO:0031648 9 6 0,000 0,02224362 0,08110622 ! regulation of hydrogen peroxide metabolic process GO:0010310 7 6 0,000 0,02224362 0,08098534 ! positive regulation of T-helper 1 cell differentiation GO:0045627 9 6 0,000 0,02224362 0,08086483 ! regulation of viral transcription GO:0046782 11 6 0,000 0,02224362 0,08074467 ! progesterone metabolic process GO:0042448 12 6 0,000 0,02224362 0,08062487 ! negative regulation of axon extension GO:0030517 24 6 0,000 0,02224362 0,08050543 ! activation of Ras GTPase activity GO:0032856 13 6 0,000 0,02224362 0,08038634 GO:0032862|activation of Rho GTPase activity, ! removal of superoxide radicals GO:0019430 12 6 0,000 0,02224362 0,0802676 ! triglyceride catabolic process GO:0019433 10 6 0,000 0,02224362 0,08014921 ! determination of adult lifespan GO:0008340 17 6 0,000 0,02224362 0,08003117 ! ectodermal gut morphogenesis GO:0048567 16 6 0,000 0,02224362 0,07991348 GO:0007439|ectodermal gut development, ! cerebellar cortex formation GO:0021697 8 6 0,000 0,02224362 0,07979613 ! neural plate development GO:0001840 9 6 0,000 0,02224362 0,07967913 ! catecholamine transport GO:0051937 9 6 0,000 0,02224362 0,07956247 ! negative regulation of NF-kappaB import into nucleus GO:0042347 15 6 0,000 0,02224362 0,07944615 ! sensory cilium assembly GO:0035058 10 6 0,000 0,02224362 0,07933017 ! organ or tissue specific immune response GO:0002251 8 6 0,000 0,02224362 0,07921453 ! cytoplasmic microtubule organization GO:0031122 18 6 0,000 0,02224362 0,07909922 ! maternal placenta development GO:0001893 12 6 0,000 0,02224362 0,07898425 ! regulation of T cell receptor signaling pathway GO:0050856 11 6 0,000 0,02224362 0,07886962 ! negative regulation of smooth muscle contraction GO:0045986 12 6 0,000 0,02224362 0,07875531 ! negative regulation of B cell activation GO:0050869 14 6 0,000 0,02224362 0,07864134 ! metallo-sulfur cluster assembly GO:0031163 6 6 0,000 0,02224362 0,0785277 GO:0016226|iron-sulfur cluster assembly, ! negative regulation of synaptic transmission GO:0050805 14 6 0,000 0,02224362 0,07841438 ! positive regulation of coagulation GO:0050820 13 6 0,000 0,02224362 0,07830139 ! cellular anion homeostasis GO:0030002 11 6 0,000 0,02224362 0,07818873 GO:0055081|anion homeostasis, ! regulation of homeostatic process GO:0032844 148 62 1,000 0,02270069 0,07968072 ! integrin-mediated signaling pathway GO:0007229 160 64 1,000 0,02408457 0,08441695 ! steroid hormone receptor signaling pathway GO:0030518 146 66 1,000 0,02550221 0,08925775 ! tRNA transcription GO:0009304 17 7 0,000 0,02590285 0,09053027 ! positive regulation of MHC class II biosynthetic process GO:0045348 13 7 0,000 0,02590285 0,09040094 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 14 7 0,000 0,02590285 0,09027198 ! behavioral response to cocaine GO:0048148 14 7 0,000 0,02590285 0,09014339 ! regulation of helicase activity GO:0051095 16 7 0,000 0,02590285 0,09001516 ! cytokinesis during cell cycle GO:0033205 14 7 0,000 0,02590285 0,0898873 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 13 7 0,000 0,02590285 0,0897598 ! sleep GO:0030431 16 7 0,000 0,02590285 0,08963266 ! tumor necrosis factor-mediated signaling pathway GO:0033209 10 7 0,000 0,02590285 0,08950588 ! chaperone mediated protein folding requiring cofactor GO:0051085 12 7 0,000 0,02590285 0,08937946 ! negative regulation of cellular catabolic process GO:0031330 12 7 0,000 0,02590285 0,08925339 ! nucleotide-sugar transport GO:0015780 11 7 0,000 0,02590285 0,08912769 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02590285 0,08900233 GO:0070193|synaptonemal complex organization, ! forebrain neuron differentiation GO:0021879 16 7 0,000 0,02590285 0,08887733 ! regulation of lipid catabolic process GO:0050994 17 7 0,000 0,02590285 0,08875267 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02590285 0,08862837 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! platelet activating factor metabolic process GO:0046469 12 7 0,000 0,02590285 0,08850441 ! N-acetylglucosamine catabolic process GO:0006046 10 7 0,000 0,02590285 0,08838081 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! Golgi to plasma membrane transport GO:0006893 14 7 0,000 0,02590285 0,08825754 ! SMAD protein complex assembly GO:0007183 13 7 0,000 0,02590285 0,08813462 ! glycolipid transport GO:0046836 11 7 0,000 0,02590285 0,08801204 ! protein amino acid sulfation GO:0006477 10 7 0,000 0,02590285 0,0878898 GO:0051923|sulfation, ! neuron adhesion GO:0007158 14 7 0,000 0,02590285 0,0877679 ! negative regulation of JAK-STAT cascade GO:0046426 17 7 0,000 0,02590285 0,08764634 ! establishment of tissue polarity GO:0007164 8 7 0,000 0,02590285 0,08752511 ! nucleotide-excision repair, DNA incision GO:0033683 11 7 0,000 0,02590285 0,08740422 ! mRNA stabilization GO:0048255 18 7 0,000 0,02590285 0,08728366 GO:0043489|RNA stabilization, ! pericardium development GO:0060039 16 7 0,000 0,02590285 0,08716344 ! fibril organization GO:0043206 17 7 0,000 0,02590285 0,08704354 ! oxaloacetate metabolic process GO:0006107 13 7 0,000 0,02590285 0,08692398 ! regulation of gluconeogenesis GO:0006111 8 7 0,000 0,02590285 0,08680474 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 15 7 0,000 0,02590285 0,08668583 ! positive regulation of neurotransmitter transport GO:0051590 16 7 0,000 0,02590285 0,08656725 ! lipoprotein transport GO:0042953 14 7 0,000 0,02590285 0,08644898 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 10 7 0,000 0,02590285 0,08633105 ! rhythmic behavior GO:0007622 17 7 0,000 0,02590285 0,08621343 ! regulation of dopamine metabolic process GO:0042053 12 7 0,000 0,02590285 0,08609613 GO:0042069|regulation of catecholamine metabolic process, ! neuron remodeling GO:0016322 16 7 0,000 0,02590285 0,08597915 ! sensory perception of temperature stimulus GO:0050951 12 7 0,000 0,02590285 0,08586249 ! glucocorticoid metabolic process GO:0008211 11 7 0,000 0,02590285 0,08574615 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 14 7 0,000 0,02590285 0,08563012 ! regulation of odontogenesis GO:0042481 14 7 0,000 0,02590285 0,0855144 ! synaptic transmission, dopaminergic GO:0001963 12 7 0,000 0,02590285 0,085399 ! amyloid precursor protein catabolic process GO:0042987 15 7 0,000 0,02590285 0,0852839 ! mechanosensory behavior GO:0007638 16 7 0,000 0,02590285 0,08516912 ! DNA ligation during DNA repair GO:0051103 12 7 0,000 0,02590285 0,08505465 ! positive regulation of isotype switching GO:0045830 17 7 0,000 0,02590285 0,08494048 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 11 7 0,000 0,02590285 0,08482662 ! negative regulation of viral genome replication GO:0045071 9 7 0,000 0,02590285 0,08471306 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02590285 0,08459981 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02590285 0,08448686 ! spinal cord patterning GO:0021511 14 7 0,000 0,02590285 0,08437421 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 22 7 0,000 0,02590285 0,08426186 ! dermatan sulfate proteoglycan metabolic process GO:0050655 16 7 0,000 0,02590285 0,08414981 ! regulation of transcriptional preinitiation complex assembly GO:0045898 12 7 0,000 0,02590285 0,08403806 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 13 7 0,000 0,02590285 0,0839266 ! adrenal gland development GO:0030325 17 7 0,000 0,02590285 0,08381544 ! cysteine metabolic process GO:0006534 13 7 0,000 0,02590285 0,08370457 ! induction of apoptosis by oxidative stress GO:0008631 9 7 0,000 0,02590285 0,083594 ! ovulation GO:0030728 10 7 0,000 0,02590285 0,08348372 ! adenohypophysis development GO:0021984 11 7 0,000 0,02590285 0,08337372 ! deoxyribonucleotide biosynthetic process GO:0009263 13 7 0,000 0,02590285 0,08326402 ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 12 7 0,000 0,02590285 0,08315461 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 21 7 0,000 0,02590285 0,08304548 ! microtubule nucleation GO:0007020 21 7 0,000 0,02590285 0,08293664 ! proline biosynthetic process GO:0006561 10 7 0,000 0,02590285 0,08282808 ! tryptophan metabolic process GO:0006568 11 7 0,000 0,02590285 0,08271981 ! thyroid hormone generation GO:0006590 13 7 0,000 0,02590285 0,08261182 ! regulation of granule cell precursor proliferation GO:0021936 12 7 0,000 0,02590285 0,08250412 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 13 7 0,000 0,02590285 0,08239669 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02590285 0,08228954 ! peptidoglycan metabolic process GO:0000270 7 7 0,000 0,02590285 0,08218267 GO:0009253|peptidoglycan catabolic process, ! positive regulation of activated T cell proliferation GO:0042104 15 7 0,000 0,02590285 0,08207608 ! galactose metabolic process GO:0006012 13 7 0,000 0,02590285 0,08196976 ! vesicle fusion GO:0006906 20 7 0,000 0,02590285 0,08186372 ! response to dietary excess GO:0002021 8 7 0,000 0,02590285 0,08175795 ! maintenance of protein location in nucleus GO:0051457 19 7 0,000 0,02590285 0,08165246 ! intracellular pH reduction GO:0051452 13 7 0,000 0,02590285 0,08154724 GO:0045851|pH reduction, ! glycerol ether catabolic process GO:0044269 12 7 0,000 0,02590285 0,08144229 GO:0046464|acylglycerol catabolic process, ! melanosome organization GO:0032438 10 7 0,000 0,02590285 0,0813376 ! nucleoside transport GO:0015858 11 7 0,000 0,02590285 0,08123319 ! nucleoside salvage GO:0043174 11 7 0,000 0,02590285 0,08112905 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 16 7 0,000 0,02590285 0,08102517 ! antigen processing and presentation of endogenous peptide antigen GO:0002483 17 7 0,000 0,02590285 0,08092156 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! negative regulation of DNA recombination GO:0045910 16 7 0,000 0,02590285 0,08081821 ! parturition GO:0007567 16 7 0,000 0,02590285 0,08071512 ! positive regulation of mitotic cell cycle GO:0045931 14 7 0,000 0,02590285 0,0806123 ! rRNA modification GO:0000154 14 7 0,000 0,02590285 0,08050974 ! regulation of chromatin assembly or disassembly GO:0001672 14 7 0,000 0,02590285 0,08040744 ! spindle checkpoint GO:0031577 16 7 0,000 0,02590285 0,0803054 ! wound healing, spreading of epidermal cells GO:0035313 16 7 0,000 0,02590285 0,08020362 ! regulation of cholesterol biosynthetic process GO:0045540 14 7 0,000 0,02590285 0,0801021 ! monocyte differentiation GO:0030224 16 7 0,000 0,02590285 0,08000083 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 15 7 0,000 0,02590285 0,07989982 ! centrosome duplication GO:0051298 14 7 0,000 0,02590285 0,07979906 ! hyaluronan metabolic process GO:0030212 9 7 0,000 0,02590285 0,07969856 ! G1 DNA damage checkpoint GO:0031571 20 7 0,000 0,02590285 0,07959831 ! anterograde axon cargo transport GO:0008089 18 7 0,000 0,02590285 0,07949831 ! fibrinolysis GO:0042730 11 7 0,000 0,02590285 0,07939857 ! negative regulation of insulin receptor signaling pathway GO:0046627 16 7 0,000 0,02590285 0,07929907 ! skeletal muscle contraction GO:0003009 8 7 0,000 0,02590285 0,07919982 ! eating behavior GO:0042755 8 7 0,000 0,02590285 0,07910082 ! B cell lineage commitment GO:0002326 21 7 0,000 0,02590285 0,07900207 ! antigen processing and presentation of exogenous antigen GO:0019884 10 7 0,000 0,02590285 0,07890356 ! positive regulation of systemic arterial blood pressure GO:0003084 11 7 0,000 0,02590285 0,0788053 ! negative regulation of interferon-gamma production GO:0032689 13 7 0,000 0,02590285 0,07870728 ! negative regulation of systemic arterial blood pressure GO:0003085 19 7 0,000 0,02590285 0,07860951 ! respiratory chain complex IV assembly GO:0008535 14 7 0,000 0,02590285 0,07851198 ! cranial nerve morphogenesis GO:0021602 12 7 0,000 0,02590285 0,07841469 ! phosphatidylinositol biosynthetic process GO:0006661 19 7 0,000 0,02590285 0,07831764 ! purine deoxyribonucleotide metabolic process GO:0009151 8 7 0,000 0,02590285 0,07822084 ! regulation of interleukin-1 beta production GO:0032651 11 7 0,000 0,02590285 0,07812427 ! regulation of interleukin-10 production GO:0032653 13 7 0,000 0,02590285 0,07802794 ! positive regulation of tumor necrosis factor production GO:0032760 10 7 0,000 0,02590285 0,07793184 ! positive regulation of monooxygenase activity GO:0032770 12 7 0,000 0,02590285 0,07783599 ! cell differentiation in hindbrain GO:0021533 10 7 0,000 0,02590285 0,07774036 ! histone ubiquitination GO:0016574 9 7 0,000 0,02590285 0,07764498 ! transcription from RNA polymerase I promoter GO:0006360 14 7 0,000 0,02590285 0,07754982 ! T cell lineage commitment GO:0002360 16 7 0,000 0,02590285 0,0774549 ! positive regulation of immunoglobulin mediated immune response GO:0002891 16 7 0,000 0,02590285 0,07736022 GO:0002714|positive regulation of B cell mediated immunity, ! regulation of lipid transport GO:0032368 14 7 0,000 0,02590285 0,07726576 ! membrane to membrane docking GO:0022614 14 7 0,000 0,02590285 0,07717153 ! transcription termination GO:0006353 14 7 0,000 0,02590285 0,07707754 ! coenzyme A metabolic process GO:0015936 12 7 0,000 0,02590285 0,07698377 ! anaphase GO:0051322 18 7 0,000 0,02590285 0,07689023 GO:0000090|mitotic anaphase, ! peptidyl-histidine modification GO:0018202 17 7 0,000 0,02590285 0,07679691 ! axonal fasciculation GO:0007413 19 7 0,000 0,02590285 0,07670383 ! negative regulation of nuclear division GO:0051784 15 7 0,000 0,02590285 0,07661096 GO:0045839|negative regulation of mitosis, ! lipopolysaccharide-mediated signaling pathway GO:0031663 16 7 0,000 0,02590285 0,07651833 ! energy coupled proton transport, against electrochemical gradient GO:0015988 13 7 0,000 0,02590285 0,07642591 GO:0015991|ATP hydrolysis coupled proton transport, ! peptidyl-threonine modification GO:0018210 26 7 0,000 0,02590285 0,07633372 ! diuresis GO:0030146 12 7 0,000 0,02590285 0,07624175 GO:0030147|natriuresis, ! regulation of myoblast differentiation GO:0045661 16 7 0,000 0,02590285 0,07615001 ! thiamin metabolic process GO:0006772 7 7 0,000 0,02590285 0,07605848 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02590285 0,07596717 ! antibiotic transport GO:0042891 9 7 0,000 0,02590285 0,07587609 ! regulation of epidermal cell differentiation GO:0045604 8 7 0,000 0,02590285 0,07578522 ! tetrahydrobiopterin biosynthetic process GO:0006729 9 7 0,000 0,02590285 0,07569457 ! positive regulation of T-helper 2 cell differentiation GO:0045630 13 7 0,000 0,02590285 0,07560413 ! regulation of T-helper 1 cell differentiation GO:0045625 10 7 0,000 0,02590285 0,07551391 ! negative regulation of transmission of nerve impulse GO:0051970 15 7 0,000 0,02590285 0,07542391 ! melanin biosynthetic process GO:0042438 10 7 0,000 0,02590285 0,07533411 ! aspartate family amino acid catabolic process GO:0009068 10 7 0,000 0,02590285 0,07524454 ! dopamine biosynthetic process GO:0042416 18 7 0,000 0,02590285 0,07515517 ! regulation of protein homodimerization activity GO:0043496 18 7 0,000 0,02590285 0,07506602 ! regulation of oxygen and reactive oxygen species metabolic process GO:0080010 13 7 0,000 0,02590285 0,07497708 ! nonprotein amino acid metabolic process GO:0019794 15 7 0,000 0,02590285 0,07488835 ! regulation of T cell mediated cytotoxicity GO:0001914 19 7 0,000 0,02590285 0,07479983 ! endosome to lysosome transport GO:0008333 12 7 0,000 0,02590285 0,07471152 ! protein modification by small protein removal GO:0070646 19 7 0,000 0,02590285 0,07462342 ! lymphocyte activation during immune response GO:0002285 11 7 0,000 0,02590285 0,07453552 ! positive regulation of fibrinolysis GO:0051919 12 7 0,000 0,02590285 0,07444783 ! negative regulation of telomere maintenance GO:0032205 13 7 0,000 0,02590285 0,07436035 ! toll-like receptor signaling pathway GO:0002224 10 7 0,000 0,02590285 0,07427307 ! regulation of synaptic transmission, dopaminergic GO:0032225 11 7 0,000 0,02590285 0,074186 ! muscle adaptation GO:0043500 13 7 0,000 0,02590285 0,07409913 ! embryonic heart tube development GO:0035050 14 7 0,000 0,02590285 0,07401246 ! retina homeostasis GO:0001895 12 7 0,000 0,02590285 0,073926 ! negative regulation of nucleotide metabolic process GO:0045980 13 7 0,000 0,02590285 0,07383974 ! protein amino acid prenylation GO:0018346 19 7 0,000 0,02590285 0,07375368 ! positive regulation of microtubule polymerization GO:0031116 15 7 0,000 0,02590285 0,07366782 ! defense response to Gram-negative bacterium GO:0050829 10 7 0,000 0,02590285 0,07358216 ! negative regulation of cell growth GO:0030308 142 67 1,000 0,02622352 0,07440656 ! chromosome segregation GO:0007059 127 67 1,000 0,02622352 0,07432024 ! regulation of lipase activity GO:0060191 137 68 1,000 0,02695304 0,07629928 ! negative regulation of cell size GO:0045792 144 69 1,000 0,02769072 0,0782968 ! lung development GO:0030324 165 69 1,000 0,02769072 0,07820628 ! urogenital system development GO:0001655 149 69 1,000 0,02769072 0,07811597 ! intracellular receptor-mediated signaling pathway GO:0030522 156 71 1,000 0,02919026 0,08225123 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 17 8 0,000 0,02954848 0,08316468 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 18 8 0,000 0,02954848 0,08306898 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 18 8 0,000 0,02954848 0,0829735 ! somatic diversification of immune receptors via somatic mutation GO:0002566 12 8 0,000 0,02954848 0,08287823 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 17 8 0,000 0,02954848 0,08278319 ! regulation of interferon-alpha production GO:0032647 11 8 0,000 0,02954848 0,08268836 ! generation of neurons in the forebrain GO:0021872 18 8 0,000 0,02954848 0,08259376 ! male meiosis GO:0007140 9 8 0,000 0,02954848 0,08249936 ! glycerol-3-phosphate metabolic process GO:0006072 15 8 0,000 0,02954848 0,08240518 ! neutral lipid biosynthetic process GO:0046460 12 8 0,000 0,02954848 0,08231122 GO:0046463|acylglycerol biosynthetic process, ! regulation of cellular amine metabolic process GO:0033238 13 8 0,000 0,02954848 0,08221747 ! meiotic prophase I GO:0007128 14 8 0,000 0,02954848 0,08212394 ! response to zinc ion GO:0010043 12 8 0,000 0,02954848 0,08203062 ! carbohydrate phosphorylation GO:0046835 11 8 0,000 0,02954848 0,08193751 ! actin-myosin filament sliding GO:0033275 13 8 0,000 0,02954848 0,08184461 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! protein thiol-disulfide exchange GO:0006467 10 8 0,000 0,02954848 0,08175192 ! receptor guanylyl cyclase signaling pathway GO:0007168 10 8 0,000 0,02954848 0,08165944 ! signal peptide processing GO:0006465 12 8 0,000 0,02954848 0,08156717 ! prostaglandin biosynthetic process GO:0001516 15 8 0,000 0,02954848 0,0814751 GO:0046457|prostanoid biosynthetic process, ! neurotransmitter uptake GO:0001504 18 8 0,000 0,02954848 0,08138325 ! macrophage chemotaxis GO:0048246 12 8 0,000 0,02954848 0,0812916 ! succinate metabolic process GO:0006105 17 8 0,000 0,02954848 0,08120016 ! tachykinin receptor signaling pathway GO:0007217 12 8 0,000 0,02954848 0,08110892 ! membrane hyperpolarization GO:0060081 11 8 0,000 0,02954848 0,08101789 ! detection of mechanical stimulus involved in sensory perception GO:0050974 18 8 0,000 0,02954848 0,08092707 ! estrogen metabolic process GO:0008210 17 8 0,000 0,02954848 0,08083644 ! negative regulation of muscle cell differentiation GO:0051148 17 8 0,000 0,02954848 0,08074602 ! T-helper 1 type immune response GO:0042088 12 8 0,000 0,02954848 0,0806558 ! regulation of response to extracellular stimulus GO:0032104 14 8 0,000 0,02954848 0,08056578 GO:0032107|regulation of response to nutrient levels, ! chaperone-mediated protein complex assembly GO:0051131 13 8 0,000 0,02954848 0,08047597 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02954848 0,08038635 ! reflex GO:0060004 17 8 0,000 0,02954848 0,08029693 ! endothelial cell differentiation GO:0045446 17 8 0,000 0,02954848 0,08020771 ! glycerolipid catabolic process GO:0046503 14 8 0,000 0,02954848 0,08011869 ! hemoglobin metabolic process GO:0020027 14 8 0,000 0,02954848 0,08002987 ! inositol phosphate-mediated signaling GO:0048016 11 8 0,000 0,02954848 0,07994124 ! pigment granule organization GO:0048753 17 8 0,000 0,02954848 0,07985281 ! activation of caspase activity by cytochrome c GO:0008635 14 8 0,000 0,02954848 0,07976458 ! regulation of defense response to virus by host GO:0050691 9 8 0,000 0,02954848 0,07967654 ! regulation of defense response to virus by virus GO:0050690 22 8 0,000 0,02954848 0,07958869 ! astrocyte differentiation GO:0048708 19 8 0,000 0,02954848 0,07950104 ! histidine catabolic process GO:0006548 10 8 0,000 0,02954848 0,07941358 GO:0009077|histidine family amino acid catabolic process, ! outer mitochondrial membrane organization GO:0007008 16 8 0,000 0,02954848 0,07932631 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! inner mitochondrial membrane organization GO:0007007 15 8 0,000 0,02954848 0,07923923 ! L-phenylalanine metabolic process GO:0006558 12 8 0,000 0,02954848 0,07915235 GO:0006559|L-phenylalanine catabolic process, ! ER overload response GO:0006983 13 8 0,000 0,02954848 0,07906565 ! regulation of interleukin-6 biosynthetic process GO:0045408 13 8 0,000 0,02954848 0,07897915 ! regulation of pigmentation during development GO:0048070 25 8 0,000 0,02954848 0,07889283 ! melanin metabolic process GO:0006582 17 8 0,000 0,02954848 0,07880671 ! tetrahydrobiopterin metabolic process GO:0046146 11 8 0,000 0,02954848 0,07872077 ! embryonic eye morphogenesis GO:0048048 16 8 0,000 0,02954848 0,07863501 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 13 8 0,000 0,02954848 0,07854945 ! positive regulation of endothelial cell migration GO:0010595 19 8 0,000 0,02954848 0,07846407 ! macrophage activation GO:0042116 13 8 0,000 0,02954848 0,07837887 ! regulation of muscle hypertrophy GO:0014743 12 8 0,000 0,02954848 0,07829386 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 17 8 0,000 0,02954848 0,07820904 ! positive regulation of insulin secretion GO:0032024 17 8 0,000 0,02954848 0,0781244 ! cerebral cortex neuron differentiation GO:0021895 16 8 0,000 0,02954848 0,07803994 ! purine salvage GO:0043101 12 8 0,000 0,02954848 0,07795566 ! synaptic transmission, glutamatergic GO:0035249 24 8 0,000 0,02954848 0,07787157 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02954848 0,07778765 ! regulation of multicellular organismal metabolic process GO:0044246 12 8 0,000 0,02954848 0,07770392 ! osteoblast development GO:0002076 17 8 0,000 0,02954848 0,07762037 ! positive regulation of vasodilation GO:0045909 14 8 0,000 0,02954848 0,07753699 ! negative regulation of translational initiation GO:0045947 12 8 0,000 0,02954848 0,0774538 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 23 8 0,000 0,02954848 0,07737078 ! lipopolysaccharide biosynthetic process GO:0009103 9 8 0,000 0,02954848 0,07728795 ! response to UV-B GO:0010224 17 8 0,000 0,02954848 0,07720529 ! protein targeting to vacuole GO:0006623 14 8 0,000 0,02954848 0,0771228 ! protein retention in ER lumen GO:0006621 14 8 0,000 0,02954848 0,07704049 ! intermediate filament organization GO:0045109 12 8 0,000 0,02954848 0,07695836 ! cardiac muscle cell differentiation GO:0055007 31 8 0,000 0,02954848 0,0768764 ! cellular extravasation GO:0045123 13 8 0,000 0,02954848 0,07679462 ! cardiac muscle cell development GO:0055013 14 8 0,000 0,02954848 0,07671301 ! response to antibiotic GO:0046677 11 8 0,000 0,02954848 0,07663157 ! transcription-coupled nucleotide-excision repair GO:0006283 14 8 0,000 0,02954848 0,07655031 ! positive regulation of production of molecular mediator of immune response GO:0002702 31 8 0,000 0,02954848 0,07646922 ! DNA topological change GO:0006265 12 8 0,000 0,02954848 0,0763883 ! response to tropane GO:0014073 15 8 0,000 0,02954848 0,07630755 GO:0042220|response to cocaine, ! regulation of T cell differentiation in the thymus GO:0033081 14 8 0,000 0,02954848 0,07622697 ! melanosome transport GO:0032402 13 8 0,000 0,02954848 0,07614656 ! regulation of interleukin-4 production GO:0032673 18 8 0,000 0,02954848 0,07606632 ! glycosylceramide metabolic process GO:0006677 10 8 0,000 0,02954848 0,07598625 ! mast cell activation GO:0045576 14 8 0,000 0,02954848 0,07590635 ! multicellular organismal aging GO:0010259 20 8 0,000 0,02954848 0,07582662 ! gas homeostasis GO:0033483 14 8 0,000 0,02954848 0,07574705 ! dendrite morphogenesis GO:0048813 14 8 0,000 0,02954848 0,07566765 ! phosphatidylserine metabolic process GO:0006658 9 8 0,000 0,02954848 0,07558842 ! regulation of interleukin-1 production GO:0032652 14 8 0,000 0,02954848 0,07550935 ! nucleosome disassembly GO:0006337 14 8 0,000 0,02954848 0,07543045 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 11 8 0,000 0,02954848 0,07535171 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of interferon-gamma production GO:0032729 12 8 0,000 0,02954848 0,07527314 ! establishment of chromosome localization GO:0051303 14 8 0,000 0,02954848 0,07519473 GO:0050000|chromosome localization, ! mitochondrion morphogenesis GO:0070584 15 8 0,000 0,02954848 0,07511648 ! intracellular lipid transport GO:0032365 16 8 0,000 0,02954848 0,0750384 ! response to tumor cell GO:0002347 16 8 0,000 0,02954848 0,07496048 ! regulation of immune response to tumor cell GO:0002837 15 8 0,000 0,02954848 0,07488272 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 17 8 0,000 0,02954848 0,07480512 ! positive regulation of erythrocyte differentiation GO:0045648 30 8 0,000 0,02954848 0,07472768 ! positive regulation of epidermis development GO:0045684 13 8 0,000 0,02954848 0,07465041 ! positive regulation of leukocyte chemotaxis GO:0002690 18 8 0,000 0,02954848 0,07457329 GO:0002688|regulation of leukocyte chemotaxis, ! regulation of synaptic transmission, glutamatergic GO:0051966 18 8 0,000 0,02954848 0,07449633 ! hormone catabolic process GO:0042447 17 8 0,000 0,02954848 0,07441953 ! glycolipid catabolic process GO:0019377 16 8 0,000 0,02954848 0,07434289 GO:0046479|glycosphingolipid catabolic process, ! lymph node development GO:0048535 11 8 0,000 0,02954848 0,0742664 ! positive regulation of ATPase activity GO:0032781 13 8 0,000 0,02954848 0,07419007 ! negative regulation of viral reproduction GO:0048525 10 8 0,000 0,02954848 0,0741139 ! positive regulation of glucose import GO:0046326 8 8 0,000 0,02954848 0,07403789 GO:0010828|positive regulation of glucose transport, ! myeloid cell homeostasis GO:0002262 15 8 0,000 0,02954848 0,07396203 ! adult feeding behavior GO:0008343 10 8 0,000 0,02954848 0,07388633 ! regulation of Rac protein signal transduction GO:0035020 18 8 0,000 0,02954848 0,07381078 ! ATP catabolic process GO:0006200 11 8 0,000 0,02954848 0,07373539 ! blastocyst growth GO:0001832 19 8 0,000 0,02954848 0,07366014 ! trophectodermal cell differentiation GO:0001829 13 8 0,000 0,02954848 0,07358506 ! negative regulation of organic acid transport GO:0032891 13 8 0,000 0,02954848 0,07351012 ! pattern recognition receptor signaling pathway GO:0002221 13 8 0,000 0,02954848 0,07343534 ! negative regulation of calcium ion transport GO:0051926 13 8 0,000 0,02954848 0,07336071 ! regulation of synaptic transmission, GABAergic GO:0032228 17 8 0,000 0,02954848 0,07328624 ! negative regulation of blood vessel endothelial cell migration GO:0043537 22 8 0,000 0,02954848 0,07321191 ! positive regulation of NF-kappaB import into nucleus GO:0042346 15 8 0,000 0,02954848 0,07313773 ! pyrimidine nucleotide catabolic process GO:0006244 16 8 0,000 0,02954848 0,07306371 ! amino sugar catabolic process GO:0046348 11 8 0,000 0,02954848 0,07298983 GO:0006043|glucosamine catabolic process, ! B cell receptor signaling pathway GO:0050853 22 8 0,000 0,02954848 0,0729161 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 18 8 0,000 0,02954848 0,07284252 ! positive regulation of smooth muscle contraction GO:0045987 15 8 0,000 0,02954848 0,07276909 ! behavioral response to nicotine GO:0035095 12 8 0,000 0,02954848 0,07269581 ! negative regulation of DNA replication initiation GO:0032297 10 8 0,000 0,02954848 0,07262268 GO:0000076|DNA replication checkpoint, ! protein prenylation GO:0018342 21 8 0,000 0,02954848 0,07254969 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 18 8 0,000 0,02954848 0,07247685 ! NAD biosynthetic process GO:0009435 17 8 0,000 0,02954848 0,07240415 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 17 8 0,000 0,02954848 0,07233161 ! regulation of microtubule polymerization GO:0031113 17 8 0,000 0,02954848 0,0722592 ! respiratory tube development GO:0030323 171 72 1,000 0,02995199 0,0731727 ! positive regulation of protein amino acid phosphorylation GO:0001934 123 74 1,000 0,03149899 0,07687516 ! respiratory system development GO:0060541 175 74 1,000 0,03149899 0,07679844 ! regulation of transcription factor activity GO:0051090 137 75 1,000 0,03228414 0,07863425 GO:0090046|regulation of transcription regulator activity, ! reproductive structure development GO:0048608 131 75 1,000 0,03228414 0,07855592 ! cell-matrix adhesion GO:0007160 181 76 1,000 0,03307695 0,08040497 ! axon extension GO:0048675 16 9 0,000 0,03318058 0,08057668 ! 'de novo' posttranslational protein folding GO:0051084 15 9 0,000 0,03318058 0,08049667 ! regulation of epithelial cell differentiation GO:0030856 18 9 0,000 0,03318058 0,08041681 ! pentose-phosphate shunt GO:0006098 16 9 0,000 0,03318058 0,08033711 GO:0006740|NADPH regeneration, ! DNA synthesis during DNA repair GO:0000731 18 9 0,000 0,03318058 0,08025757 ! cell proliferation in forebrain GO:0021846 18 9 0,000 0,03318058 0,08017818 ! neutral lipid catabolic process GO:0046461 14 9 0,000 0,03318058 0,08009896 ! reproductive behavior GO:0019098 22 9 0,000 0,03318058 0,08001989 ! cellular copper ion homeostasis GO:0006878 12 9 0,000 0,03318058 0,07994097 ! Golgi to endosome transport GO:0006895 25 9 0,000 0,03318058 0,07986221 ! UTP metabolic process GO:0046051 10 9 0,000 0,03318058 0,07978361 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! RNA methylation GO:0001510 16 9 0,000 0,03318058 0,07970516 ! induction of positive chemotaxis GO:0050930 17 9 0,000 0,03318058 0,07962686 ! regulation of activated T cell proliferation GO:0046006 19 9 0,000 0,03318058 0,07954872 ! artery development GO:0060840 25 9 0,000 0,03318058 0,07947073 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 14 9 0,000 0,03318058 0,07939289 ! cerebral cortex cell migration GO:0021795 18 9 0,000 0,03318058 0,07931521 ! equilibrioception GO:0050957 20 9 0,000 0,03318058 0,07923768 ! cytoplasmic sequestering of transcription factor GO:0042994 15 9 0,000 0,03318058 0,0791603 ! chemosensory behavior GO:0007635 21 9 0,000 0,03318058 0,07908307 ! middle ear morphogenesis GO:0042474 14 9 0,000 0,03318058 0,07900599 ! amyloid precursor protein metabolic process GO:0042982 18 9 0,000 0,03318058 0,07892906 ! leukocyte degranulation GO:0043299 16 9 0,000 0,03318058 0,07885228 ! ganglioside metabolic process GO:0001573 22 9 0,000 0,03318058 0,07877565 ! negative regulation of endocytosis GO:0045806 12 9 0,000 0,03318058 0,07869917 ! positive regulation of gene expression, epigenetic GO:0045815 22 9 0,000 0,03318058 0,07862284 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 16 9 0,000 0,03318058 0,07854665 ! ribonucleoside triphosphate catabolic process GO:0009203 12 9 0,000 0,03318058 0,07847061 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! lipopolysaccharide metabolic process GO:0008653 10 9 0,000 0,03318058 0,07839472 ! glycerol ether biosynthetic process GO:0046504 14 9 0,000 0,03318058 0,07831898 ! protein targeting to ER GO:0045047 25 9 0,000 0,03318058 0,07824338 ! ceramide biosynthetic process GO:0046513 20 9 0,000 0,03318058 0,07816793 ! T cell selection GO:0045058 27 9 0,000 0,03318058 0,07809263 ! embryonic cranial skeleton morphogenesis GO:0048701 20 9 0,000 0,03318058 0,07801746 ! glycine catabolic process GO:0006546 15 9 0,000 0,03318058 0,07794245 ! cytoskeletal anchoring at plasma membrane GO:0007016 31 9 0,000 0,03318058 0,07786757 ! endosome organization GO:0007032 20 9 0,000 0,03318058 0,07779285 ! regulation of phosphoprotein phosphatase activity GO:0043666 24 9 0,000 0,03318058 0,07771826 ! retinoic acid receptor signaling pathway GO:0048384 16 9 0,000 0,03318058 0,07764382 ! regulation of type I interferon production GO:0032479 12 9 0,000 0,03318058 0,07756952 ! mannose metabolic process GO:0006013 13 9 0,000 0,03318058 0,07749536 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 25 9 0,000 0,03318058 0,07742134 ! retrograde transport, endosome to Golgi GO:0042147 29 9 0,000 0,03318058 0,07734747 ! positive regulation of mesenchymal cell proliferation GO:0002053 34 9 0,000 0,03318058 0,07727373 ! Rac protein signal transduction GO:0016601 20 9 0,000 0,03318058 0,07720014 ! receptor clustering GO:0043113 20 9 0,000 0,03318058 0,07712668 ! neurotransmitter catabolic process GO:0042135 18 9 0,000 0,03318058 0,07705337 ! positive regulation of calcium ion transport into cytosol GO:0010524 12 9 0,000 0,03318058 0,07698019 ! retinol metabolic process GO:0042572 20 9 0,000 0,03318058 0,07690716 ! negative regulation of muscle contraction GO:0045932 16 9 0,000 0,03318058 0,07683426 ! determination of anterior/posterior axis, embryo GO:0008595 17 9 0,000 0,03318058 0,0767615 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 24 9 0,000 0,03318058 0,07668888 ! oligodendrocyte development GO:0014003 11 9 0,000 0,03318058 0,07661639 ! peptidyl-asparagine modification GO:0018196 15 9 0,000 0,03318058 0,07654405 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! regulation of circadian rhythm GO:0042752 20 9 0,000 0,03318058 0,07647183 ! thiamin and derivative metabolic process GO:0042723 10 9 0,000 0,03318058 0,07639976 ! response to amine stimulus GO:0014075 13 9 0,000 0,03318058 0,07632782 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! establishment of melanosome localization GO:0032401 14 9 0,000 0,03318058 0,07625602 ! nucleoside diphosphate metabolic process GO:0009132 17 9 0,000 0,03318058 0,07618435 ! erythrocyte development GO:0048821 17 9 0,000 0,03318058 0,07611281 ! nucleoside bisphosphate metabolic process GO:0033865 18 9 0,000 0,03318058 0,07604141 ! regulation of mitochondrial membrane potential GO:0051881 19 9 0,000 0,03318058 0,07597015 ! renal water homeostasis GO:0003091 15 9 0,000 0,03318058 0,07589901 ! postreplication repair GO:0006301 25 9 0,000 0,03318058 0,07582801 ! protein import into peroxisome matrix GO:0016558 20 9 0,000 0,03318058 0,07575714 ! icosanoid secretion GO:0032309 15 9 0,000 0,03318058 0,07568641 GO:0050482|arachidonic acid secretion, ! cerebellum morphogenesis GO:0021587 14 9 0,000 0,03318058 0,07561581 GO:0021696|cerebellar cortex morphogenesis, ! regulation of cell division GO:0051302 17 9 0,000 0,03318058 0,07554534 ! retinal ganglion cell axon guidance GO:0031290 14 9 0,000 0,03318058 0,075475 ! morphogenesis of a polarized epithelium GO:0001738 12 9 0,000 0,03318058 0,07540479 ! regulation of transcription from RNA polymerase III promoter GO:0006359 13 9 0,000 0,03318058 0,07533471 ! sterol catabolic process GO:0016127 14 9 0,000 0,03318058 0,07526476 GO:0006707|cholesterol catabolic process, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 15 9 0,000 0,03318058 0,07519494 ! negative regulation of cytokine secretion GO:0050710 16 9 0,000 0,03318058 0,07512525 ! regulation of T-helper 1 type immune response GO:0002825 12 9 0,000 0,03318058 0,07505569 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 9 0,000 0,03318058 0,07498626 GO:0002820|negative regulation of adaptive immune response, ! regulation of macrophage activation GO:0043030 17 9 0,000 0,03318058 0,07491695 ! regulation of macrophage differentiation GO:0045649 16 9 0,000 0,03318058 0,07484778 ! neuromuscular process controlling posture GO:0050884 15 9 0,000 0,03318058 0,07477873 ! negative regulation of lymphocyte differentiation GO:0045620 20 9 0,000 0,03318058 0,07470981 ! branched chain family amino acid catabolic process GO:0009083 19 9 0,000 0,03318058 0,07464102 ! regulation of synaptogenesis GO:0051963 15 9 0,000 0,03318058 0,07457235 ! purine base metabolic process GO:0006144 25 9 0,000 0,03318058 0,07450381 ! pigment granule transport GO:0051904 17 9 0,000 0,03318058 0,07443539 ! regulation of telomere maintenance GO:0032204 17 9 0,000 0,03318058 0,07436711 ! pyrimidine base metabolic process GO:0006206 22 9 0,000 0,03318058 0,07429894 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 10 9 0,000 0,03318058 0,0742309 ! regulation of muscle adaptation GO:0043502 14 9 0,000 0,03318058 0,07416299 ! regulation of amino acid transport GO:0051955 12 9 0,000 0,03318058 0,0740952 ! fusion of sperm to egg plasma membrane GO:0007342 12 9 0,000 0,03318058 0,07402753 ! mitochondrion localization GO:0051646 18 9 0,000 0,03318058 0,07395999 ! regulation of vesicle-mediated transport GO:0060627 136 77 1,000 0,03387737 0,07544432 ! regulation of catabolic process GO:0009894 173 77 1,000 0,03387737 0,07537561 ! antigen processing and presentation GO:0019882 117 78 1,000 0,03468533 0,07710306 ! positive regulation of lymphocyte activation GO:0051251 142 78 1,000 0,03468533 0,07703296 ! steroid biosynthetic process GO:0006694 146 79 1,000 0,03550076 0,07877234 ! protein oligomerization GO:0051259 149 79 1,000 0,03550076 0,07870086 ! negative regulation of organelle organization GO:0010639 181 80 1,000 0,03632359 0,08045197 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 22 10 0,000 0,03679918 0,08143151 ! autophagic vacuole formation GO:0000045 17 10 0,000 0,03679918 0,08135782 ! negative regulation of blood pressure GO:0045776 26 10 0,000 0,03679918 0,08128426 ! negative regulation of lipid biosynthetic process GO:0051055 15 10 0,000 0,03679918 0,08121083 ! associative learning GO:0008306 21 10 0,000 0,03679918 0,08113753 ! regulation of phosphatase activity GO:0010921 28 10 0,000 0,03679918 0,08106437 ! phosphate transport GO:0006817 24 10 0,000 0,03679918 0,08099134 ! cell volume homeostasis GO:0006884 17 10 0,000 0,03679918 0,08091844 ! regulation of long-term neuronal synaptic plasticity GO:0048169 32 10 0,000 0,03679918 0,08084567 ! CTP metabolic process GO:0046036 11 10 0,000 0,03679918 0,08077303 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! SMAD protein nuclear translocation GO:0007184 21 10 0,000 0,03679918 0,08070053 ! regulation of smooth muscle cell migration GO:0014910 27 10 0,000 0,03679918 0,08062815 ! GTP metabolic process GO:0046039 11 10 0,000 0,03679918 0,0805559 ! syncytium formation by plasma membrane fusion GO:0000768 18 10 0,000 0,03679918 0,08048378 GO:0007520|myoblast fusion, ! elastic fiber assembly GO:0048251 17 10 0,000 0,03679918 0,0804118 ! social behavior GO:0035176 29 10 0,000 0,03679918 0,08033993 ! COPI coating of Golgi vesicle GO:0048205 23 10 0,000 0,03679918 0,0802682 GO:0048200|Golgi transport vesicle coating, ! smoothened signaling pathway GO:0007224 18 10 0,000 0,03679918 0,0801966 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 22 10 0,000 0,03679918 0,08012512 ! androgen metabolic process GO:0008209 17 10 0,000 0,03679918 0,08005377 ! phospholipid efflux GO:0033700 19 10 0,000 0,03679918 0,07998255 ! regulation of carbohydrate biosynthetic process GO:0043255 16 10 0,000 0,03679918 0,07991146 ! bile acid and bile salt transport GO:0015721 15 10 0,000 0,03679918 0,07984049 ! regulation of mesenchymal cell proliferation GO:0010464 36 10 0,000 0,03679918 0,07976964 ! positive regulation of heart contraction GO:0045823 17 10 0,000 0,03679918 0,07969892 ! lung alveolus development GO:0048286 26 10 0,000 0,03679918 0,07962833 ! pathogenesis GO:0009405 17 10 0,000 0,03679918 0,07955786 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03679918 0,07948752 ! negative regulation of striated muscle development GO:0045843 26 10 0,000 0,03679918 0,0794173 ! sphingoid biosynthetic process GO:0046520 22 10 0,000 0,03679918 0,07934721 ! regulation of S phase of mitotic cell cycle GO:0007090 18 10 0,000 0,03679918 0,07927724 ! endoderm development GO:0007492 18 10 0,000 0,03679918 0,07920739 ! arginine catabolic process GO:0006527 17 10 0,000 0,03679918 0,07913766 ! myeloid leukocyte mediated immunity GO:0002444 14 10 0,000 0,03679918 0,07906806 ! proline metabolic process GO:0006560 13 10 0,000 0,03679918 0,07899858 ! glucan biosynthetic process GO:0009250 14 10 0,000 0,03679918 0,07892922 GO:0005978|glycogen biosynthetic process, ! phosphagen metabolic process GO:0006599 17 10 0,000 0,03679918 0,07885999 GO:0006600|creatine metabolic process, ! polyamine biosynthetic process GO:0006596 13 10 0,000 0,03679918 0,07879087 ! V(D)J recombination GO:0033151 34 10 0,000 0,03679918 0,07872188 ! reverse cholesterol transport GO:0043691 19 10 0,000 0,03679918 0,07865301 ! central nervous system neuron axonogenesis GO:0021955 23 10 0,000 0,03679918 0,07858425 GO:0021952|central nervous system projection neuron axonogenesis, ! regulation of stress fiber formation GO:0051492 34 10 0,000 0,03679918 0,07851562 ! B cell proliferation GO:0042100 19 10 0,000 0,03679918 0,07844711 ! nucleobase biosynthetic process GO:0046112 26 10 0,000 0,03679918 0,07837872 ! regulation of sodium ion transport GO:0002028 26 10 0,000 0,03679918 0,07831044 ! multicellular organism growth GO:0035264 19 10 0,000 0,03679918 0,07824229 ! phagocytosis, engulfment GO:0006911 33 10 0,000 0,03679918 0,07817425 ! neurotransmitter biosynthetic process GO:0042136 18 10 0,000 0,03679918 0,07810633 ! ruffle organization GO:0031529 17 10 0,000 0,03679918 0,07803853 ! epithelial cell development GO:0002064 21 10 0,000 0,03679918 0,07797085 ! lens development in camera-type eye GO:0002088 17 10 0,000 0,03679918 0,07790328 ! retinoic acid metabolic process GO:0042573 14 10 0,000 0,03679918 0,07783583 ! intestinal cholesterol absorption GO:0030299 19 10 0,000 0,03679918 0,0777685 ! positive regulation of translational initiation GO:0045948 12 10 0,000 0,03679918 0,07770129 ! positive regulation vascular endothelial growth factor production GO:0010575 25 10 0,000 0,03679918 0,07763419 ! chondroitin sulfate biosynthetic process GO:0030206 22 10 0,000 0,03679918 0,0775672 GO:0030204|chondroitin sulfate metabolic process, ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 25 10 0,000 0,03679918 0,07750033 ! motor axon guidance GO:0008045 22 10 0,000 0,03679918 0,07743358 ! copper ion homeostasis GO:0055070 13 10 0,000 0,03679918 0,07736694 ! regulation of bone resorption GO:0045124 25 10 0,000 0,03679918 0,07730042 ! regulation of gliogenesis GO:0014013 23 10 0,000 0,03679918 0,07723401 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 23 10 0,000 0,03679918 0,07716771 ! alpha-beta T cell differentiation GO:0046632 24 10 0,000 0,03679918 0,07710153 ! segment specification GO:0007379 15 10 0,000 0,03679918 0,07703546 ! regulation of insulin receptor signaling pathway GO:0046626 22 10 0,000 0,03679918 0,07696951 ! blastoderm segmentation GO:0007350 19 10 0,000 0,03679918 0,07690367 ! base-excision repair, AP site formation GO:0006285 15 10 0,000 0,03679918 0,07683794 ! response to dsRNA GO:0043331 23 10 0,000 0,03679918 0,07677232 ! DNA ligation GO:0006266 18 10 0,000 0,03679918 0,07670681 ! regulation of fat cell differentiation GO:0045598 18 10 0,000 0,03679918 0,07664142 ! purine nucleoside triphosphate catabolic process GO:0009146 13 10 0,000 0,03679918 0,07657614 ! melanosome localization GO:0032400 16 10 0,000 0,03679918 0,07651097 ! glycosphingolipid biosynthetic process GO:0006688 16 10 0,000 0,03679918 0,07644591 ! regulation of B cell differentiation GO:0045577 24 10 0,000 0,03679918 0,07638096 ! positive regulation of interleukin-6 production GO:0032755 14 10 0,000 0,03679918 0,07631612 ! spinal cord motor neuron differentiation GO:0021522 19 10 0,000 0,03679918 0,07625139 ! induction of an organ GO:0001759 17 10 0,000 0,03679918 0,07618677 ! leukocyte activation during immune response GO:0002366 15 10 0,000 0,03679918 0,07612226 GO:0002263|cell activation during immune response, ! mRNA cleavage GO:0006379 18 10 0,000 0,03679918 0,07605786 ! protein sumoylation GO:0016925 17 10 0,000 0,03679918 0,07599356 ! synaptic vesicle endocytosis GO:0048488 23 10 0,000 0,03679918 0,07592938 ! hindbrain morphogenesis GO:0021575 19 10 0,000 0,03679918 0,07586531 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03679918 0,07580134 ! regulation of DNA replication initiation GO:0030174 14 10 0,000 0,03679918 0,07573748 ! positive regulation of interleukin-1 beta secretion GO:0050718 15 10 0,000 0,03679918 0,07567373 ! salivary gland development GO:0007431 28 10 0,000 0,03679918 0,07561008 ! ubiquinone metabolic process GO:0006743 17 10 0,000 0,03679918 0,07554654 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of acute inflammatory response GO:0002675 18 10 0,000 0,03679918 0,07548311 ! midbrain development GO:0030901 14 10 0,000 0,03679918 0,07541979 ! musculoskeletal movement GO:0050881 16 10 0,000 0,03679918 0,07535657 GO:0050879|multicellular organismal movement, ! multicellular organismal water homeostasis GO:0050891 16 10 0,000 0,03679918 0,07529346 ! methionine biosynthetic process GO:0009086 21 10 0,000 0,03679918 0,07523045 ! serine family amino acid catabolic process GO:0009071 18 10 0,000 0,03679918 0,07516755 ! nicotinamide nucleotide biosynthetic process GO:0019359 20 10 0,000 0,03679918 0,07510475 ! quaternary ammonium group transport GO:0015697 22 10 0,000 0,03679918 0,07504206 ! thyroid hormone metabolic process GO:0042403 16 10 0,000 0,03679918 0,07497947 ! negative regulation of BMP signaling pathway GO:0030514 19 10 0,000 0,03679918 0,07491699 ! positive regulation of viral reproduction GO:0048524 19 10 0,000 0,03679918 0,07485461 ! detection of calcium ion GO:0005513 24 10 0,000 0,03679918 0,07479234 ! establishment of pigment granule localization GO:0051905 18 10 0,000 0,03679918 0,07473016 ! blastocyst formation GO:0001825 18 10 0,000 0,03679918 0,0746681 ! regulation of fibrinolysis GO:0051917 20 10 0,000 0,03679918 0,07460613 ! cerebellar cortex development GO:0021695 16 10 0,000 0,03679918 0,07454427 ! natural killer cell mediated immunity GO:0002228 19 10 0,000 0,03679918 0,07448251 GO:0042267|natural killer cell mediated cytotoxicity, ! positive regulation of amine transport GO:0051954 17 10 0,000 0,03679918 0,07442085 ! response to nicotine GO:0035094 20 10 0,000 0,03679918 0,07435929 ! negative regulation of immune effector process GO:0002698 23 10 0,000 0,03679918 0,07429784 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 20 10 0,000 0,03679918 0,07423649 ! meiosis GO:0007126 143 81 1,000 0,03715375 0,07488995 GO:0051327|M phase of meiotic cell cycle, ! muscle cell differentiation GO:0042692 178 81 1,000 0,03715375 0,07482821 ! response to hypoxia GO:0001666 178 81 1,000 0,03715375 0,07476657 ! cell-substrate adhesion GO:0031589 189 82 1,000 0,03799119 0,07638888 ! meiotic cell cycle GO:0051321 144 82 1,000 0,03799119 0,07632606 ! response to oxygen levels GO:0070482 183 83 1,000 0,03883584 0,07795888 ! response to metal ion GO:0010038 158 84 1,000 0,03968763 0,07960335 ! negative regulation of muscle development GO:0048635 27 11 0,000 0,04040433 0,0809744 ! respiratory burst GO:0045730 17 11 0,000 0,04040433 0,08090802 ! very-long-chain fatty acid metabolic process GO:0000038 22 11 0,000 0,04040433 0,08084176 ! neuron fate specification GO:0048665 18 11 0,000 0,04040433 0,08077561 ! telencephalon cell migration GO:0022029 23 11 0,000 0,04040433 0,08070956 ! thyroid gland development GO:0030878 26 11 0,000 0,04040433 0,08064362 ! synapsis GO:0007129 14 11 0,000 0,04040433 0,08057779 GO:0070192|chromosome organization involved in meiosis, ! N-glycan processing GO:0006491 24 11 0,000 0,04040433 0,08051206 ! Golgi vesicle budding GO:0048194 26 11 0,000 0,04040433 0,08044645 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 27 11 0,000 0,04040433 0,08038094 ! response to pain GO:0048265 27 11 0,000 0,04040433 0,08031553 ! detection of mechanical stimulus GO:0050982 22 11 0,000 0,04040433 0,08025024 ! keratinocyte proliferation GO:0043616 19 11 0,000 0,04040433 0,08018504 ! blood vessel remodeling GO:0001974 30 11 0,000 0,04040433 0,08011996 ! positive regulation of endothelial cell proliferation GO:0001938 23 11 0,000 0,04040433 0,08005498 ! bone resorption GO:0045453 16 11 0,000 0,04040433 0,07999011 ! positive regulation of interferon-gamma biosynthetic process GO:0045078 15 11 0,000 0,04040433 0,07992534 ! negative regulation of proteolysis GO:0045861 25 11 0,000 0,04040433 0,07986067 ! regulation of catecholamine secretion GO:0050433 20 11 0,000 0,04040433 0,07979611 ! melanocyte differentiation GO:0030318 20 11 0,000 0,04040433 0,07973166 GO:0050931|pigment cell differentiation, ! histidine metabolic process GO:0006547 22 11 0,000 0,04040433 0,0796673 GO:0009075|histidine family amino acid metabolic process, ! syncytium formation GO:0006949 20 11 0,000 0,04040433 0,07960306 ! telomere maintenance via telomerase GO:0007004 24 11 0,000 0,04040433 0,07953891 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 21 11 0,000 0,04040433 0,07947487 ! regulation of intracellular pH GO:0051453 21 11 0,000 0,04040433 0,07941093 ! substrate-bound cell migration GO:0006929 14 11 0,000 0,04040433 0,0793471 ! UV protection GO:0009650 20 11 0,000 0,04040433 0,07928337 ! adult heart development GO:0007512 16 11 0,000 0,04040433 0,07921973 ! chondrocyte differentiation GO:0002062 27 11 0,000 0,04040433 0,07915621 ! regulation of lipoprotein lipase activity GO:0051004 23 11 0,000 0,04040433 0,07909278 ! macroautophagy GO:0016236 19 11 0,000 0,04040433 0,07902946 ! temperature homeostasis GO:0001659 18 11 0,000 0,04040433 0,07896623 ! behavioral fear response GO:0001662 27 11 0,000 0,04040433 0,07890311 GO:0002209|behavioral defense response, ! positive regulation of muscle contraction GO:0045933 19 11 0,000 0,04040433 0,07884009 ! negative regulation of ossification GO:0030279 27 11 0,000 0,04040433 0,07877717 ! regulation of vascular endothelial growth factor production GO:0010574 26 11 0,000 0,04040433 0,07871435 ! regulation of smoothened signaling pathway GO:0008589 27 11 0,000 0,04040433 0,07865163 ! positive regulation of peptide secretion GO:0002793 24 11 0,000 0,04040433 0,078589 ! alpha-beta T cell activation GO:0046631 26 11 0,000 0,04040433 0,07852648 ! negative regulation of axonogenesis GO:0050771 37 11 0,000 0,04040433 0,07846406 ! regulation of organ growth GO:0046620 14 11 0,000 0,04040433 0,07840174 ! pigment granule localization GO:0051875 20 11 0,000 0,04040433 0,07833952 ! positive regulation of T cell mediated immunity GO:0002711 26 11 0,000 0,04040433 0,07827739 ! vasoconstriction GO:0042310 20 11 0,000 0,04040433 0,07821536 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 12 11 0,000 0,04040433 0,07815344 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 20 11 0,000 0,04040433 0,07809161 ! embryonic axis specification GO:0000578 19 11 0,000 0,04040433 0,07802987 ! sphingomyelin metabolic process GO:0006684 18 11 0,000 0,04040433 0,07796824 ! purine ribonucleotide catabolic process GO:0009154 17 11 0,000 0,04040433 0,0779067 ! positive regulation of Rho GTPase activity GO:0032321 31 11 0,000 0,04040433 0,07784526 ! nitric oxide metabolic process GO:0046209 17 11 0,000 0,04040433 0,07778392 GO:0006809|nitric oxide biosynthetic process, ! DNA methylation GO:0006306 19 11 0,000 0,04040433 0,07772267 GO:0006305|DNA alkylation, ! negative regulation of tumor necrosis factor production GO:0032720 16 11 0,000 0,04040433 0,07766152 ! positive regulation of interleukin-1 secretion GO:0050716 16 11 0,000 0,04040433 0,07760046 ! cellular metabolic compound salvage GO:0043094 16 11 0,000 0,04040433 0,0775395 ! prophase GO:0051324 17 11 0,000 0,04040433 0,07747864 ! neuroblast proliferation GO:0007405 25 11 0,000 0,04040433 0,07741787 ! nucleosome positioning GO:0016584 15 11 0,000 0,04040433 0,0773572 ! regulation of isotype switching GO:0045191 24 11 0,000 0,04040433 0,07729662 ! regulation of interleukin-1 beta secretion GO:0050706 17 11 0,000 0,04040433 0,07723614 ! negative regulation of neurological system process GO:0031645 21 11 0,000 0,04040433 0,07717575 ! apical protein localization GO:0045176 18 11 0,000 0,04040433 0,07711546 ! acid secretion GO:0046717 20 11 0,000 0,04040433 0,07705526 ! regulation of osteoclast differentiation GO:0045670 17 11 0,000 0,04040433 0,07699516 ! positive regulation of neuron differentiation GO:0045666 22 11 0,000 0,04040433 0,07693514 ! positive regulation of leukocyte migration GO:0002687 28 11 0,000 0,04040433 0,07687523 ! nitric oxide mediated signal transduction GO:0007263 26 11 0,000 0,04040433 0,0768154 ! regulation of T-helper 2 cell differentiation GO:0045628 21 11 0,000 0,04040433 0,07675567 ! somatic diversification of immunoglobulins during immune response GO:0002208 23 11 0,000 0,04040433 0,07669603 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! thymus development GO:0048538 29 11 0,000 0,04040433 0,07663648 ! cholesterol efflux GO:0033344 21 11 0,000 0,04040433 0,07657703 ! positive regulation of JNK cascade GO:0046330 23 11 0,000 0,04040433 0,07651767 ! oocyte development GO:0048599 20 11 0,000 0,04040433 0,0764584 ! negative regulation of glucose import GO:0046325 18 11 0,000 0,04040433 0,07639922 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 26 11 0,000 0,04040433 0,07634013 ! embryonic gut development GO:0048566 19 11 0,000 0,04040433 0,07628114 ! regulation of organic acid transport GO:0032890 19 11 0,000 0,04040433 0,07622223 ! establishment or maintenance of apical/basal cell polarity GO:0035088 24 11 0,000 0,04040433 0,07616342 ! activation of innate immune response GO:0002218 16 11 0,000 0,04040433 0,0761047 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 37 11 0,000 0,04040433 0,07604606 ! cardiac cell differentiation GO:0035051 36 11 0,000 0,04040433 0,07598752 ! lysogeny GO:0030069 22 11 0,000 0,04040433 0,07592907 GO:0019047|provirus integration, ! prepulse inhibition GO:0060134 18 11 0,000 0,04040433 0,07587071 ! T cell receptor signaling pathway GO:0050852 29 11 0,000 0,04040433 0,07581243 ! negative regulation of growth GO:0045926 168 85 1,000 0,04054649 0,07602079 ! regulation of neuron differentiation GO:0045664 187 85 1,000 0,04054649 0,07596249 ! positive regulation of cell activation GO:0050867 161 86 1,000 0,04141237 0,07752524 GO:0002696|positive regulation of leukocyte activation, ! regulation of membrane protein ectodomain proteolysis GO:0051043 25 12 0,000 0,0439961 0,08229898 ! positive regulation of blood pressure GO:0045777 18 12 0,000 0,0439961 0,08223602 ! regulation of positive chemotaxis GO:0050926 22 12 0,000 0,0439961 0,08217315 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 17 12 0,000 0,0439961 0,08211037 ! protein complex disassembly GO:0043241 28 12 0,000 0,0439961 0,08204769 GO:0043624|cellular protein complex disassembly, ! dopamine receptor signaling pathway GO:0007212 28 12 0,000 0,0439961 0,08198511 ! hippocampus development GO:0021766 29 12 0,000 0,0439961 0,08192262 ! positive regulation of transcription factor import into nucleus GO:0042993 25 12 0,000 0,0439961 0,08186022 ! cytokine biosynthetic process GO:0042089 23 12 0,000 0,0439961 0,08179793 ! T cell proliferation GO:0042098 32 12 0,000 0,0439961 0,08173572 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 27 12 0,000 0,0439961 0,08167361 ! regulation of exit from mitosis GO:0007096 19 12 0,000 0,0439961 0,0816116 ! ventral spinal cord development GO:0021517 25 12 0,000 0,0439961 0,08154968 ! glycolipid biosynthetic process GO:0009247 18 12 0,000 0,0439961 0,08148785 ! drug transport GO:0015893 16 12 0,000 0,0439961 0,08142612 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 23 12 0,000 0,0439961 0,08136448 ! oligodendrocyte differentiation GO:0048709 17 12 0,000 0,0439961 0,08130293 ! tyrosine metabolic process GO:0006570 19 12 0,000 0,0439961 0,08124148 ! polyamine metabolic process GO:0006595 18 12 0,000 0,0439961 0,08118012 ! focal adhesion formation GO:0048041 37 12 0,000 0,0439961 0,08111885 ! negative regulation of endothelial cell migration GO:0010596 26 12 0,000 0,0439961 0,08105767 ! regulation of Cdc42 protein signal transduction GO:0032489 27 12 0,000 0,0439961 0,08099659 GO:0043088|regulation of Cdc42 GTPase activity, ! forebrain cell migration GO:0021885 24 12 0,000 0,0439961 0,0809356 ! lipid digestion GO:0044241 21 12 0,000 0,0439961 0,0808747 ! regulation of calcium ion transport into cytosol GO:0010522 17 12 0,000 0,0439961 0,08081389 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,0439961 0,08075317 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 25 12 0,000 0,0439961 0,08069255 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 20 12 0,000 0,0439961 0,08063201 ! acyl-CoA metabolic process GO:0006637 21 12 0,000 0,0439961 0,08057157 ! protein targeting to peroxisome GO:0006625 27 12 0,000 0,0439961 0,08051122 ! negative regulation of myeloid leukocyte differentiation GO:0002762 17 12 0,000 0,0439961 0,08045095 ! snRNA metabolic process GO:0016073 30 12 0,000 0,0439961 0,08039078 GO:0016180|snRNA processing, ! synaptic vesicle exocytosis GO:0016079 22 12 0,000 0,0439961 0,0803307 ! regulation of interleukin-8 production GO:0032677 22 12 0,000 0,0439961 0,08027071 ! regulation of interleukin-12 production GO:0032655 19 12 0,000 0,0439961 0,0802108 ! fucose catabolic process GO:0019317 25 12 0,000 0,0439961 0,08015099 GO:0042355|L-fucose catabolic process, ! immunoglobulin production during immune response GO:0002381 24 12 0,000 0,0439961 0,08009126 ! mRNA polyadenylation GO:0006378 24 12 0,000 0,0439961 0,08003163 ! autonomic nervous system development GO:0048483 24 12 0,000 0,0439961 0,07997208 ! regulation of hormone metabolic process GO:0032350 28 12 0,000 0,0439961 0,07991262 ! zymogen activation GO:0031638 18 12 0,000 0,0439961 0,07985325 ! T cell homeostasis GO:0043029 28 12 0,000 0,0439961 0,07979397 ! regulation of interleukin-1 secretion GO:0050704 18 12 0,000 0,0439961 0,07973477 ! glutathione biosynthetic process GO:0006750 15 12 0,000 0,0439961 0,07967567 ! regulation of leukocyte migration GO:0002685 29 12 0,000 0,0439961 0,07961665 ! oocyte differentiation GO:0009994 21 12 0,000 0,0439961 0,07955772 ! leukocyte mediated cytotoxicity GO:0001909 28 12 0,000 0,0439961 0,07949887 ! quinone cofactor metabolic process GO:0042375 20 12 0,000 0,0439961 0,07944011 ! negative regulation of mast cell proliferation GO:0070667 24 12 0,000 0,0439961 0,07938144 GO:0042130|negative regulation of T cell proliferation, ! regulation of blood vessel endothelial cell migration GO:0043535 38 12 0,000 0,0439961 0,07932286 ! defense response to Gram-positive bacterium GO:0050830 14 12 0,000 0,0439961 0,07926436 ! defense response to fungus GO:0050832 15 12 0,000 0,0439961 0,07920595 ! developmental induction GO:0031128 22 12 0,000 0,0439961 0,07914762 GO:0045168|cell-cell signaling involved in cell fate specification, ! embryonic placenta development GO:0001892 21 12 0,000 0,0439961 0,07908938 ! lamellipodium assembly GO:0030032 24 12 0,000 0,0439961 0,07903123 ! response to cold GO:0009409 17 12 0,000 0,0439961 0,07897316 ! establishment of cell polarity GO:0030010 21 12 0,000 0,0439961 0,07891518 ! regulation of synapse organization GO:0050807 18 12 0,000 0,0439961 0,07885728 ! regulation of DNA binding GO:0051101 167 89 1,000 0,04405146 0,07889863 ! response to inorganic substance GO:0010035 173 90 1,000 0,04494477 0,08043961 ! positive regulation of protein modification process GO:0031401 156 90 1,000 0,04494477 0,08038072 ! response to unfolded protein GO:0006986 139 90 1,000 0,04494477 0,08032192 ! ossification GO:0001503 205 91 1,000 0,04584477 0,08187045 ! gland development GO:0048732 220 91 1,000 0,04584477 0,08181064 ! bone development GO:0060348 206 92 1,000 0,04675141 0,08336766 ! negative regulation of cell projection organization GO:0031345 42 13 0,000 0,04757452 0,08477357 ! cGMP metabolic process GO:0046068 18 13 0,000 0,04757452 0,08471178 GO:0006182|cGMP biosynthetic process, ! 'de novo' protein folding GO:0006458 26 13 0,000 0,04757452 0,08465008 ! regulation of chemokine production GO:0032642 18 13 0,000 0,04757452 0,08458847 ! double-strand break repair via homologous recombination GO:0000724 19 13 0,000 0,04757452 0,08452695 GO:0000725|recombinational repair, ! folic acid and derivative biosynthetic process GO:0009396 25 13 0,000 0,04757452 0,08446552 ! peroxisomal transport GO:0043574 28 13 0,000 0,04757452 0,08440418 ! glycosaminoglycan catabolic process GO:0006027 15 13 0,000 0,04757452 0,08434293 ! cartilage condensation GO:0001502 22 13 0,000 0,04757452 0,08428177 ! negative regulation of transcription factor import into nucleus GO:0042992 31 13 0,000 0,04757452 0,0842207 ! organelle fusion GO:0048284 36 13 0,000 0,04757452 0,08415971 ! positive regulation of lipid metabolic process GO:0045834 30 13 0,000 0,04757452 0,08409881 ! negative regulation of lipid metabolic process GO:0045833 20 13 0,000 0,04757452 0,08403801 ! pseudouridine synthesis GO:0001522 19 13 0,000 0,04757452 0,08397728 ! endocrine pancreas development GO:0031018 25 13 0,000 0,04757452 0,08391665 ! positive regulation of cell growth GO:0030307 24 13 0,000 0,04757452 0,0838561 ! regulation of interferon-gamma biosynthetic process GO:0045072 19 13 0,000 0,04757452 0,08379565 ! two-component signal transduction system (phosphorelay) GO:0000160 22 13 0,000 0,04757452 0,08373527 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 27 13 0,000 0,04757452 0,08367499 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 28 13 0,000 0,04757452 0,08361479 ! regulation of skeletal muscle fiber development GO:0048742 32 13 0,000 0,04757452 0,08355468 ! methionine metabolic process GO:0006555 31 13 0,000 0,04757452 0,08349466 ! plasma membrane organization GO:0007009 27 13 0,000 0,04757452 0,08343472 ! ribonucleotide catabolic process GO:0009261 21 13 0,000 0,04757452 0,08337486 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 31 13 0,000 0,04757452 0,0833151 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! Golgi organization GO:0007030 25 13 0,000 0,04757452 0,08325542 ! indolalkylamine metabolic process GO:0006586 19 13 0,000 0,04757452 0,08319582 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! response to X-ray GO:0010165 28 13 0,000 0,04757452 0,08313631 ! cytokine metabolic process GO:0042107 24 13 0,000 0,04757452 0,08307688 ! exocrine system development GO:0035272 34 13 0,000 0,04757452 0,08301754 ! asymmetric protein localization GO:0008105 24 13 0,000 0,04757452 0,08295829 ! membrane protein proteolysis GO:0033619 33 13 0,000 0,04757452 0,08289912 GO:0006509|membrane protein ectodomain proteolysis, ! monoamine transport GO:0015844 21 13 0,000 0,04757452 0,08284003 ! L-glutamate transport GO:0015813 30 13 0,000 0,04757452 0,08278103 GO:0015800|acidic amino acid transport, ! negative regulation of mitotic cell cycle GO:0045930 35 13 0,000 0,04757452 0,08272211 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 30 13 0,000 0,04757452 0,08266327 ! protein homotetramerization GO:0051289 24 13 0,000 0,04757452 0,08260452 ! regulation of cytokine production during immune response GO:0002718 25 13 0,000 0,04757452 0,08254585 ! regulation of natural killer cell mediated immunity GO:0002715 28 13 0,000 0,04757452 0,08248727 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 23 13 0,000 0,04757452 0,08242877 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 15 13 0,000 0,04757452 0,08237035 ! nucleoside triphosphate catabolic process GO:0009143 22 13 0,000 0,04757452 0,08231201 ! ribosomal large subunit biogenesis GO:0042273 13 13 0,000 0,04757452 0,08225376 ! gastrulation with mouth forming second GO:0001702 29 13 0,000 0,04757452 0,08219559 ! histone methylation GO:0016571 29 13 0,000 0,04757452 0,0821375 ! chromatin silencing GO:0006342 29 13 0,000 0,04757452 0,08207949 ! gland morphogenesis GO:0022612 31 13 0,000 0,04757452 0,08202157 ! regulation of acute inflammatory response GO:0002673 24 13 0,000 0,04757452 0,08196372 ! regulation of epidermis development GO:0045682 19 13 0,000 0,04757452 0,08190596 ! positive regulation of T-helper cell differentiation GO:0045624 22 13 0,000 0,04757452 0,08184828 ! aromatic amino acid family catabolic process GO:0009074 20 13 0,000 0,04757452 0,08179068 ! pyridine nucleotide biosynthetic process GO:0019363 24 13 0,000 0,04757452 0,08173317 ! spleen development GO:0048536 24 13 0,000 0,04757452 0,08167573 ! regulation of mRNA stability GO:0043488 32 13 0,000 0,04757452 0,08161837 ! digestive tract morphogenesis GO:0048546 31 13 0,000 0,04757452 0,0815611 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 24 13 0,000 0,04757452 0,0815039 ! anterior/posterior axis specification GO:0009948 22 13 0,000 0,04757452 0,08144678 ! regulation of RNA splicing GO:0043484 22 13 0,000 0,04757452 0,08138975 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 34 13 0,000 0,04757452 0,08133279 ! regulation of fatty acid oxidation GO:0046320 34 13 0,000 0,04757452 0,08127592 ! positive regulation of homeostatic process GO:0032846 23 13 0,000 0,04757452 0,08121912 ! mRNA 3'-end processing GO:0031124 25 13 0,000 0,04757452 0,0811624 ! insulin secretion GO:0030073 24 13 0,000 0,04757452 0,08110576 ! positive regulation of calcium-mediated signaling GO:0050850 28 13 0,000 0,04757452 0,08104921 ! cytoplasmic sequestering of protein GO:0051220 25 13 0,000 0,04757452 0,08099273 ! acrosome reaction GO:0007340 19 13 0,000 0,04757452 0,08093632 ! regulation of synapse structure and activity GO:0050803 19 13 0,000 0,04757452 0,08088 ! regulation of steroid biosynthetic process GO:0050810 20 13 0,000 0,04757452 0,08082376 ! sterol metabolic process GO:0016125 166 94 1,000 0,04858436 0,08248199 ! sex differentiation GO:0007548 171 96 1,000 0,05044312 0,08557816 ! response to protein stimulus GO:0051789 158 96 1,000 0,05044312 0,08551877 ! rRNA transcription GO:0009303 28 14 0,000 0,05113965 0,08663951 ! positive regulation of small GTPase mediated signal transduction GO:0051057 27 14 0,000 0,05113965 0,08657947 GO:0046579|positive regulation of Ras protein signal transduction, ! regulation of S phase GO:0033261 26 14 0,000 0,05113965 0,08651951 ! water transport GO:0006833 21 14 0,000 0,05113965 0,08645963 GO:0042044|fluid transport, ! myotube differentiation GO:0014902 26 14 0,000 0,05113965 0,08639984 ! non-recombinational repair GO:0000726 29 14 0,000 0,05113965 0,08634013 GO:0006303|double-strand break repair via nonhomologous end joining, ! vesicle targeting, to, from or within Golgi GO:0048199 29 14 0,000 0,05113965 0,0862805 ! retina development in camera-type eye GO:0060041 28 14 0,000 0,05113965 0,08622096 ! hair follicle morphogenesis GO:0031069 27 14 0,000 0,05113965 0,0861615 ! RNA polyadenylation GO:0043631 32 14 0,000 0,05113965 0,08610212 ! lipid localization GO:0010876 32 14 0,000 0,05113965 0,08604282 GO:0019915|lipid storage, ! palate development GO:0060021 32 14 0,000 0,05113965 0,0859836 ! negative regulation of protein amino acid phosphorylation GO:0001933 36 14 0,000 0,05113965 0,08592446 ! regulated secretory pathway GO:0045055 24 14 0,000 0,05113965 0,08586541 ! chondroitin sulfate proteoglycan metabolic process GO:0050654 29 14 0,000 0,05113965 0,08580644 ! nucleotide-sugar metabolic process GO:0009225 21 14 0,000 0,05113965 0,08574754 ! arginine metabolic process GO:0006525 21 14 0,000 0,05113965 0,08568873 ! deoxyribonucleotide catabolic process GO:0009264 21 14 0,000 0,05113965 0,08563 ! cell-cell junction assembly GO:0007043 32 14 0,000 0,05113965 0,08557135 ! regulation of heart rate GO:0002027 25 14 0,000 0,05113965 0,08551278 ! fear response GO:0042596 34 14 0,000 0,05113965 0,08545429 ! organic alcohol transport GO:0015850 29 14 0,000 0,05113965 0,08539588 ! negative regulation of caspase activity GO:0043154 23 14 0,000 0,05113965 0,08533755 ! branching involved in ureteric bud morphogenesis GO:0001658 31 14 0,000 0,05113965 0,0852793 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 30 14 0,000 0,05113965 0,08522113 ! neutral amino acid transport GO:0015804 28 14 0,000 0,05113965 0,08516303 ! bone mineralization GO:0030282 18 14 0,000 0,05113965 0,08510502 ! cotranslational protein targeting to membrane GO:0006613 26 14 0,000 0,05113965 0,08504709 ! negative regulation of protein import into nucleus GO:0042308 33 14 0,000 0,05113965 0,08498923 ! RNA-dependent DNA replication GO:0006278 28 14 0,000 0,05113965 0,08493146 ! T cell differentiation in the thymus GO:0033077 37 14 0,000 0,05113965 0,08487376 ! cell wall macromolecule catabolic process GO:0016998 16 14 0,000 0,05113965 0,08481614 ! regulation of cellular pH GO:0030641 27 14 0,000 0,05113965 0,0847586 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 23 14 0,000 0,05113965 0,08470113 ! ribosome assembly GO:0042255 18 14 0,000 0,05113965 0,08464375 ! cerebellum development GO:0021549 23 14 0,000 0,05113965 0,08458644 ! positive regulation of Ras GTPase activity GO:0032320 42 14 0,000 0,05113965 0,08452921 ! regulation of T-helper 2 type immune response GO:0002828 25 14 0,000 0,05113965 0,08447206 ! negative regulation of protein secretion GO:0050709 30 14 0,000 0,05113965 0,08441498 ! response to gamma radiation GO:0010332 30 14 0,000 0,05113965 0,08435798 ! positive regulation of bone mineralization GO:0030501 32 14 0,000 0,05113965 0,08430106 ! NADP metabolic process GO:0006739 24 14 0,000 0,05113965 0,08424421 ! serine family amino acid biosynthetic process GO:0009070 19 14 0,000 0,05113965 0,08418745 ! oxygen transport GO:0015671 22 14 0,000 0,05113965 0,08413075 ! catecholamine biosynthetic process GO:0042423 30 14 0,000 0,05113965 0,08407414 ! male genitalia development GO:0030539 26 14 0,000 0,05113965 0,0840176 ! regulation of RNA stability GO:0043487 33 14 0,000 0,05113965 0,08396114 ! regulation of axon extension GO:0030516 43 14 0,000 0,05113965 0,08390475 ! release of cytochrome c from mitochondria GO:0001836 31 14 0,000 0,05113965 0,08384844 ! regulation of calcium-mediated signaling GO:0050848 29 14 0,000 0,05113965 0,0837922 ! positive regulation of protein polymerization GO:0032273 27 14 0,000 0,05113965 0,08373604 ! regulation of skeletal muscle tissue development GO:0048641 35 15 0,000 0,05469154 0,08949191 ! lactation GO:0007595 30 15 0,000 0,05469154 0,08943201 ! reproductive cellular process GO:0048610 22 15 0,000 0,05469154 0,08937219 ! ER-associated protein catabolic process GO:0030433 24 15 0,000 0,05469154 0,08931245 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! tRNA modification GO:0006400 24 15 0,000 0,05469154 0,08925279 ! superoxide anion generation GO:0042554 22 15 0,000 0,05469154 0,08919321 ! pteridine and derivative biosynthetic process GO:0042559 20 15 0,000 0,05469154 0,0891337 ! negative regulation of bone remodeling GO:0046851 34 15 0,000 0,05469154 0,08907428 ! phospholipid catabolic process GO:0009395 27 15 0,000 0,05469154 0,08901494 ! copper ion transport GO:0006825 22 15 0,000 0,05469154 0,08895567 ! positive regulation of GTPase activity GO:0043547 43 15 0,000 0,05469154 0,08889649 ! cardiac muscle contraction GO:0060048 28 15 0,000 0,05469154 0,08883738 ! regulation of cell-cell adhesion GO:0022407 35 15 0,000 0,05469154 0,08877835 ! sulfate transport GO:0008272 27 15 0,000 0,05469154 0,0887194 ! response to cAMP GO:0051591 25 15 0,000 0,05469154 0,08866053 ! regulation of excitatory postsynaptic membrane potential GO:0060079 33 15 0,000 0,05469154 0,08860174 ! negative regulation of cytokine biosynthetic process GO:0042036 25 15 0,000 0,05469154 0,08854302 ! regulation of mRNA processing GO:0050684 26 15 0,000 0,05469154 0,08848439 ! response to hexose stimulus GO:0009746 25 15 0,000 0,05469154 0,08842583 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! pyrimidine ribonucleotide biosynthetic process GO:0009220 24 15 0,000 0,05469154 0,08836734 ! glycoprotein catabolic process GO:0006516 33 15 0,000 0,05469154 0,08830894 ! vesicle coating GO:0006901 38 15 0,000 0,05469154 0,08825061 ! regulation of the force of heart contraction GO:0002026 31 15 0,000 0,05469154 0,08819236 ! actin cytoskeleton reorganization GO:0031532 38 15 0,000 0,05469154 0,08813418 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 30 15 0,000 0,05469154 0,08807609 ! regulation of exocytosis GO:0017157 26 15 0,000 0,05469154 0,08801806 ! heparan sulfate proteoglycan metabolic process GO:0030201 35 15 0,000 0,05469154 0,08796012 ! G1/S transition checkpoint GO:0031575 37 15 0,000 0,05469154 0,08790225 ! intermediate filament cytoskeleton organization GO:0045104 34 15 0,000 0,05469154 0,08784446 ! positive regulation of axonogenesis GO:0050772 33 15 0,000 0,05469154 0,08778674 ! positive regulation of biomineral formation GO:0070169 33 15 0,000 0,05469154 0,0877291 ! regulation of vasodilation GO:0042312 27 15 0,000 0,05469154 0,08767154 ! regulation of T cell mediated immunity GO:0002709 36 15 0,000 0,05469154 0,08761405 ! histone deacetylation GO:0016575 24 15 0,000 0,05469154 0,08755663 ! water homeostasis GO:0030104 28 15 0,000 0,05469154 0,08749929 ! cofactor transport GO:0051181 30 15 0,000 0,05469154 0,08744203 ! synaptic transmission, cholinergic GO:0007271 24 15 0,000 0,05469154 0,08738484 ! muscle maintenance GO:0046716 26 15 0,000 0,05469154 0,08732773 ! protein-chromophore linkage GO:0018298 25 15 0,000 0,05469154 0,08727069 ! intestinal absorption GO:0050892 31 15 0,000 0,05469154 0,08721372 ! dopamine metabolic process GO:0042417 35 15 0,000 0,05469154 0,08715683 ! cAMP biosynthetic process GO:0006171 25 15 0,000 0,05469154 0,08710001 ! heme biosynthetic process GO:0006783 33 15 0,000 0,05469154 0,08704327 ! cell killing GO:0001906 32 15 0,000 0,05469154 0,0869866 ! lymphocyte homeostasis GO:0002260 33 15 0,000 0,05469154 0,08693001 ! epithelial to mesenchymal transition GO:0001837 30 15 0,000 0,05469154 0,08687349 ! positive regulation of calcium ion transport GO:0051928 21 15 0,000 0,05469154 0,08681704 ! L-fucose metabolic process GO:0042354 33 15 0,000 0,05469154 0,08676066 ! regulation of NF-kappaB import into nucleus GO:0042345 32 15 0,000 0,05469154 0,08670436 ! actin filament polymerization GO:0030041 27 15 0,000 0,05469154 0,08664813 ! cell wall macromolecule metabolic process GO:0044036 17 15 0,000 0,05469154 0,08659198 ! regulation of protein ubiquitination GO:0031396 28 16 0,000 0,05823022 0,092135 ! positive regulation of cell size GO:0045793 29 16 0,000 0,05823022 0,09207536 ! sulfur amino acid biosynthetic process GO:0000097 31 16 0,000 0,05823022 0,09201581 ! dicarboxylic acid transport GO:0006835 47 16 0,000 0,05823022 0,09195633 ! embryonic hindlimb morphogenesis GO:0035116 36 16 0,000 0,05823022 0,09189692 ! bone remodeling GO:0046849 28 16 0,000 0,05823022 0,0918376 ! negative regulation of nucleocytoplasmic transport GO:0046823 35 16 0,000 0,05823022 0,09177835 ! heterophilic cell adhesion GO:0007157 43 16 0,000 0,05823022 0,09171917 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05823022 0,09166007 ! regulation of neurotransmitter secretion GO:0046928 35 16 0,000 0,05823022 0,09160105 ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 23 16 0,000 0,05823022 0,09154211 ! positive regulation of ion transport GO:0043270 23 16 0,000 0,05823022 0,09148324 ! startle response GO:0001964 28 16 0,000 0,05823022 0,09142444 ! regulation of transmembrane transporter activity GO:0022898 27 16 0,000 0,05823022 0,09136573 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! isoprenoid biosynthetic process GO:0008299 34 16 0,000 0,05823022 0,09130708 ! regulation of interleukin-2 biosynthetic process GO:0045076 32 16 0,000 0,05823022 0,09124852 ! pyrimidine ribonucleotide metabolic process GO:0009218 27 16 0,000 0,05823022 0,09119002 ! protein polyubiquitination GO:0000209 41 16 0,000 0,05823022 0,09113161 ! glutamate metabolic process GO:0006536 25 16 0,000 0,05823022 0,09107326 ! pituitary gland development GO:0021983 30 16 0,000 0,05823022 0,09101499 ! response to osmotic stress GO:0006970 27 16 0,000 0,05823022 0,0909568 ! lysosomal transport GO:0007041 31 16 0,000 0,05823022 0,09089868 ! fructose metabolic process GO:0006000 25 16 0,000 0,05823022 0,09084064 ! L-amino acid transport GO:0015807 33 16 0,000 0,05823022 0,09078266 ! stem cell development GO:0048864 46 16 0,000 0,05823022 0,09072477 GO:0019827|stem cell maintenance, ! purine nucleoside monophosphate metabolic process GO:0009126 27 16 0,000 0,05823022 0,09066694 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! regulation of dephosphorylation GO:0035303 43 16 0,000 0,05823022 0,09060919 ! intermediate filament-based process GO:0045103 36 16 0,000 0,05823022 0,09055152 ! NLS-bearing substrate import into nucleus GO:0006607 49 16 0,000 0,05823022 0,09049392 ! negative regulation of immune response GO:0050777 38 16 0,000 0,05823022 0,09043639 ! axon cargo transport GO:0008088 46 16 0,000 0,05823022 0,09037893 ! embryonic digit morphogenesis GO:0042733 36 16 0,000 0,05823022 0,09032155 ! nucleotide-excision repair, DNA gap filling GO:0006297 25 16 0,000 0,05823022 0,09026424 ! positive regulation of protein import into nucleus GO:0042307 34 16 0,000 0,05823022 0,090207 ! DNA replication initiation GO:0006270 28 16 0,000 0,05823022 0,09014983 ! neuron recognition GO:0008038 40 16 0,000 0,05823022 0,09009274 ! mRNA splice site selection GO:0006376 44 16 0,000 0,05823022 0,09003572 ! tissue regeneration GO:0042246 27 16 0,000 0,05823022 0,08997877 ! positive regulation of cytokine secretion GO:0050715 29 16 0,000 0,05823022 0,08992189 ! negative regulation of inflammatory response GO:0050728 24 16 0,000 0,05823022 0,08986509 ! negative regulation of tissue remodeling GO:0034104 37 16 0,000 0,05823022 0,08980836 ! biomineral formation GO:0031214 22 16 0,000 0,05823022 0,08975169 ! neuromuscular synaptic transmission GO:0007274 34 16 0,000 0,05823022 0,0896951 ! C21-steroid hormone biosynthetic process GO:0006700 26 16 0,000 0,05823022 0,08963859 ! regulation of T-helper cell differentiation GO:0045622 30 16 0,000 0,05823022 0,08958214 ! glutamine family amino acid biosynthetic process GO:0009084 19 16 0,000 0,05823022 0,08952576 ! regulation of ATPase activity GO:0043462 26 16 0,000 0,05823022 0,08946946 ! aspartate family amino acid biosynthetic process GO:0009067 30 16 0,000 0,05823022 0,08941322 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 34 16 0,000 0,05823022 0,08935706 ! negative regulation of leukocyte proliferation GO:0070664 32 16 0,000 0,05823022 0,08930096 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 32 16 0,000 0,05823022 0,08924494 ! peptide hormone processing GO:0016486 27 16 0,000 0,05823022 0,08918899 ! positive regulation of cell killing GO:0031343 36 17 0,000 0,06175576 0,09452966 ! metencephalon development GO:0022037 32 17 0,000 0,06175576 0,09447046 ! negative regulation of cell cycle process GO:0010948 35 17 0,000 0,06175576 0,09441135 ! embryonic forelimb morphogenesis GO:0035115 31 17 0,000 0,06175576 0,0943523 ! signal complex assembly GO:0007172 47 17 0,000 0,06175576 0,09429333 ! gene silencing by RNA GO:0031047 38 17 0,000 0,06175576 0,09423443 ! positive regulation of receptor-mediated endocytosis GO:0048260 24 17 0,000 0,06175576 0,09417561 ! glial cell development GO:0021782 28 17 0,000 0,06175576 0,09411686 ! regulation of muscle cell differentiation GO:0051147 36 17 0,000 0,06175576 0,09405819 ! auditory receptor cell differentiation GO:0042491 36 17 0,000 0,06175576 0,09399958 ! negative regulation of peptidase activity GO:0010466 28 17 0,000 0,06175576 0,09394105 ! negative regulation of endothelial cell proliferation GO:0001937 38 17 0,000 0,06175576 0,09388259 ! negative regulation of gene expression, epigenetic GO:0045814 40 17 0,000 0,06175576 0,09382421 ! myoblast differentiation GO:0045445 50 17 0,000 0,06175576 0,0937659 ! activation of MAPKK activity GO:0000186 43 17 0,000 0,06175576 0,09370766 ! induction of apoptosis via death domain receptors GO:0008625 23 17 0,000 0,06175576 0,09364949 ! regulation of striated muscle contraction GO:0006942 23 17 0,000 0,06175576 0,0935914 ! complement activation, alternative pathway GO:0006957 19 17 0,000 0,06175576 0,09353337 ! NAD metabolic process GO:0019674 33 17 0,000 0,06175576 0,09347542 ! membrane budding GO:0006900 42 17 0,000 0,06175576 0,09341754 ! preassembly of GPI anchor in ER membrane GO:0016254 29 17 0,000 0,06175576 0,09335973 ! regulation of protein binding GO:0043393 33 17 0,000 0,06175576 0,093302 ! nucleobase metabolic process GO:0009112 43 17 0,000 0,06175576 0,09324433 ! DNA unwinding during replication GO:0006268 26 17 0,000 0,06175576 0,09318674 ! genitalia development GO:0048806 32 17 0,000 0,06175576 0,09312922 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 31 17 0,000 0,06175576 0,09307176 ! DNA fragmentation involved in apoptosis GO:0006309 27 17 0,000 0,06175576 0,09301438 ! regulation of immunoglobulin mediated immune response GO:0002889 35 17 0,000 0,06175576 0,09295707 GO:0002712|regulation of B cell mediated immunity, ! cellular amino acid derivative catabolic process GO:0042219 30 17 0,000 0,06175576 0,09289983 ! neutrophil chemotaxis GO:0030593 29 17 0,000 0,06175576 0,09284266 ! negative regulation of blood coagulation GO:0030195 25 17 0,000 0,06175576 0,09278557 ! steroid catabolic process GO:0006706 34 17 0,000 0,06175576 0,09272854 ! activation of NF-kappaB-inducing kinase activity GO:0007250 30 17 0,000 0,06175576 0,09267158 ! branched chain family amino acid metabolic process GO:0009081 37 17 0,000 0,06175576 0,09261469 ! gas transport GO:0015669 26 17 0,000 0,06175576 0,09255787 ! organic cation transport GO:0015695 32 17 0,000 0,06175576 0,09250112 ! negative regulation of homeostatic process GO:0032845 36 17 0,000 0,06175576 0,09244444 ! RNA 3'-end processing GO:0031123 37 17 0,000 0,06175576 0,09238783 ! antigen receptor-mediated signaling pathway GO:0050851 40 17 0,000 0,06175576 0,09233129 ! positive regulation of protein complex assembly GO:0031334 34 18 0,000 0,0652682 0,09752307 ! positive regulation of anti-apoptosis GO:0045768 47 18 0,000 0,0652682 0,09746346 ! phosphatidylcholine metabolic process GO:0046470 26 18 0,000 0,0652682 0,09740392 ! limbic system development GO:0021761 40 18 0,000 0,0652682 0,09734446 ! regulation of systemic arterial blood pressure by hormone GO:0001990 28 18 0,000 0,0652682 0,09728507 GO:0050886|endocrine process, ! negative regulation of ion transport GO:0043271 25 18 0,000 0,0652682 0,09722575 ! adult walking behavior GO:0007628 36 18 0,000 0,0652682 0,0971665 ! patterning of blood vessels GO:0001569 43 18 0,000 0,0652682 0,09710732 ! heart looping GO:0001947 34 18 0,000 0,0652682 0,09704822 ! ciliary or flagellar motility GO:0001539 32 18 0,000 0,0652682 0,09698919 ! regulation of viral genome replication GO:0045069 30 18 0,000 0,0652682 0,09693023 ! positive regulation of proteolysis GO:0045862 36 18 0,000 0,0652682 0,09687134 ! regulation of defense response to virus GO:0050688 35 18 0,000 0,0652682 0,09681252 ! epidermis morphogenesis GO:0048730 43 18 0,000 0,0652682 0,09675378 ! glycine metabolic process GO:0006544 30 18 0,000 0,0652682 0,0966951 ! glutamine metabolic process GO:0006541 29 18 0,000 0,0652682 0,0966365 ! response to retinoic acid GO:0032526 31 18 0,000 0,0652682 0,09657797 ! cell-substrate junction assembly GO:0007044 56 18 0,000 0,0652682 0,09651951 ! pyrimidine ribonucleoside metabolic process GO:0046131 26 18 0,000 0,0652682 0,09646111 ! DNA integration GO:0015074 32 18 0,000 0,0652682 0,09640279 ! negative regulation of protein catabolic process GO:0042177 42 18 0,000 0,0652682 0,09634455 ! positive regulation of alpha-beta T cell differentiation GO:0046638 31 18 0,000 0,0652682 0,09628637 ! ventricular cardiac muscle morphogenesis GO:0055010 30 18 0,000 0,0652682 0,09622826 ! neural crest cell migration GO:0001755 41 18 0,000 0,0652682 0,09617022 ! long-chain fatty acid transport GO:0015909 32 18 0,000 0,0652682 0,09611225 ! sphingolipid catabolic process GO:0030149 32 18 0,000 0,0652682 0,09605435 GO:0046466|membrane lipid catabolic process, ! regulation of immunoglobulin production GO:0002637 49 18 0,000 0,0652682 0,09599652 ! porphyrin biosynthetic process GO:0006779 37 18 0,000 0,0652682 0,09593876 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 33 18 0,000 0,0652682 0,09588107 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 36 18 0,000 0,0652682 0,09582345 ! aromatic compound biosynthetic process GO:0019438 26 18 0,000 0,0652682 0,0957659 ! detection of bacterium GO:0016045 22 18 0,000 0,0652682 0,09570842 ! defense response to virus GO:0051607 43 18 0,000 0,0652682 0,095651 ! positive regulation of synaptic transmission GO:0050806 35 18 0,000 0,0652682 0,09559366 ! oligosaccharide metabolic process GO:0009311 38 19 0,000 0,06876759 0,10065862 ! positive regulation of translation GO:0045727 31 19 0,000 0,06876759 0,10059834 ! negative regulation of defense response GO:0031348 27 19 0,000 0,06876759 0,10053814 ! neuron maturation GO:0042551 46 19 0,000 0,06876759 0,10047801 ! regulation of lipid biosynthetic process GO:0046890 28 19 0,000 0,06876759 0,10041795 ! 2'-deoxyribonucleotide metabolic process GO:0009394 31 19 0,000 0,06876759 0,10035796 GO:0019692|deoxyribose phosphate metabolic process, ! regulation of neuronal synaptic plasticity GO:0048168 51 19 0,000 0,06876759 0,10029805 ! protein amino acid ADP-ribosylation GO:0006471 37 19 0,000 0,06876759 0,10023821 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 28 19 0,000 0,06876759 0,10017843 ! memory GO:0007613 34 19 0,000 0,06876759 0,10011873 ! regulation of postsynaptic membrane potential GO:0060078 38 19 0,000 0,06876759 0,1000591 ! cellular response to hydrogen peroxide GO:0070301 25 19 0,000 0,06876759 0,09999954 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 37 19 0,000 0,06876759 0,09994005 ! cell differentiation in spinal cord GO:0021515 37 19 0,000 0,06876759 0,09988064 ! cerebral cortex development GO:0021987 40 19 0,000 0,06876759 0,09982129 ! pigmentation during development GO:0048066 42 19 0,000 0,06876759 0,09976201 ! response to vitamin A GO:0033189 32 19 0,000 0,06876759 0,09970281 ! heme metabolic process GO:0042168 40 19 0,000 0,06876759 0,09964367 ! neuromuscular junction development GO:0007528 43 19 0,000 0,06876759 0,09958461 ! response to lipopolysaccharide GO:0032496 34 19 0,000 0,06876759 0,09952561 ! regulation of endothelial cell migration GO:0010594 45 19 0,000 0,06876759 0,09946669 ! response to fungus GO:0009620 26 19 0,000 0,06876759 0,09940783 ! peptide cross-linking GO:0018149 39 19 0,000 0,06876759 0,09934904 ! heart process GO:0003015 32 19 0,000 0,06876759 0,09929033 GO:0060047|heart contraction, ! regulation of steroid metabolic process GO:0019218 35 19 0,000 0,06876759 0,09923168 ! visual learning GO:0008542 38 19 0,000 0,06876759 0,0991731 ! cellular pigmentation GO:0033059 37 19 0,000 0,06876759 0,09911459 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 35 19 0,000 0,06876759 0,09905615 ! peptide biosynthetic process GO:0043043 26 19 0,000 0,06876759 0,09899778 ! vitamin transport GO:0051180 31 19 0,000 0,06876759 0,09893948 ! folic acid and derivative metabolic process GO:0006760 39 19 0,000 0,06876759 0,09888124 ! positive regulation of transmission of nerve impulse GO:0051971 36 19 0,000 0,06876759 0,09882308 ! proximal/distal pattern formation GO:0009954 33 19 0,000 0,06876759 0,09876498 ! somatic recombination of immunoglobulin gene segments GO:0016447 52 19 0,000 0,06876759 0,09870695 ! embryonic organ morphogenesis GO:0048562 34 19 0,000 0,06876759 0,09864899 ! cilium assembly GO:0042384 38 19 0,000 0,06876759 0,0985911 ! peptide hormone secretion GO:0030072 32 19 0,000 0,06876759 0,09853327 ! protein secretion GO:0009306 45 20 0,000 0,07225398 0,10346804 ! protein import into nucleus, docking GO:0000059 42 20 0,000 0,07225398 0,10340743 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 32 20 0,000 0,07225398 0,10334688 ! positive regulation of ossification GO:0045778 50 20 0,000 0,07225398 0,10328641 ! skin development GO:0043588 42 20 0,000 0,07225398 0,10322601 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 40 20 0,000 0,07225398 0,10316568 ! protein amino acid deacetylation GO:0006476 34 20 0,000 0,07225398 0,10310542 ! positive regulation of nucleocytoplasmic transport GO:0046824 40 20 0,000 0,07225398 0,10304523 ! aminoglycan catabolic process GO:0006026 25 20 0,000 0,07225398 0,10298511 ! response to vitamin GO:0033273 36 20 0,000 0,07225398 0,10292506 ! transcription from RNA polymerase III promoter GO:0006383 46 20 0,000 0,07225398 0,10286508 ! forelimb morphogenesis GO:0035136 35 20 0,000 0,07225398 0,10280517 ! bile acid metabolic process GO:0008206 34 20 0,000 0,07225398 0,10274533 ! response to alkaloid GO:0043279 38 20 0,000 0,07225398 0,10268556 ! retinoid metabolic process GO:0001523 34 20 0,000 0,07225398 0,10262586 GO:0016101|diterpenoid metabolic process, ! pancreas development GO:0031016 40 20 0,000 0,07225398 0,10256623 ! apoptotic mitochondrial changes GO:0008637 42 20 0,000 0,07225398 0,10250666 ! response to carbohydrate stimulus GO:0009743 33 20 0,000 0,07225398 0,10244717 ! DNA duplex unwinding GO:0032508 30 20 0,000 0,07225398 0,10238775 GO:0032392|DNA geometric change, ! cellular response to unfolded protein GO:0034620 35 20 0,000 0,07225398 0,10232839 GO:0030968|endoplasmic reticulum unfolded protein response, ! peptidyl-serine phosphorylation GO:0018105 44 20 0,000 0,07225398 0,10226911 ! actin filament bundle formation GO:0051017 47 20 0,000 0,07225398 0,10220989 ! body fluid secretion GO:0007589 33 20 0,000 0,07225398 0,10215074 ! fatty acid beta-oxidation GO:0006635 36 20 0,000 0,07225398 0,10209166 ! peptide secretion GO:0002790 38 20 0,000 0,07225398 0,10203265 ! behavioral interaction between organisms GO:0051705 47 20 0,000 0,07225398 0,1019737 ! regulation of fatty acid metabolic process GO:0019217 45 20 0,000 0,07225398 0,10191482 ! regulation of interleukin-2 production GO:0032663 39 20 0,000 0,07225398 0,10185602 ! protein localization in mitochondrion GO:0070585 39 20 0,000 0,07225398 0,10179728 GO:0006626|protein targeting to mitochondrion, ! positive regulation of neurological system process GO:0031646 39 20 0,000 0,07225398 0,1017386 ! cell-cell junction organization GO:0045216 43 20 0,000 0,07225398 0,10168 ! negative regulation of myeloid cell differentiation GO:0045638 32 20 0,000 0,07225398 0,10162146 ! purine nucleotide catabolic process GO:0006195 32 20 0,000 0,07225398 0,10156299 ! regulation of leukocyte mediated cytotoxicity GO:0001910 44 20 0,000 0,07225398 0,10150459 ! estrogen receptor signaling pathway GO:0030520 45 20 0,000 0,07225398 0,10144625 ! regulation of glucose import GO:0046324 30 20 0,000 0,07225398 0,10138798 GO:0010827|regulation of glucose transport, ! aromatic compound catabolic process GO:0019439 31 20 0,000 0,07225398 0,10132978 ! negative regulation of T cell activation GO:0050868 41 20 0,000 0,07225398 0,10127164 ! binding of sperm to zona pellucida GO:0007339 22 20 0,000 0,07225398 0,10121358 ! negative regulation of coagulation GO:0050819 30 20 0,000 0,07225398 0,10115557 ! regulation of cell killing GO:0031341 46 21 0,000 0,07572741 0,10595766 ! phosphatidylinositol metabolic process GO:0046488 47 21 0,000 0,07572741 0,10589701 ! hormone secretion GO:0046879 39 21 0,000 0,07572741 0,10583643 ! cAMP metabolic process GO:0046058 41 21 0,000 0,07572741 0,10577591 ! regulation of neurotransmitter transport GO:0051588 44 21 0,000 0,07572741 0,10571547 ! gamma-aminobutyric acid signaling pathway GO:0007214 31 21 0,000 0,07572741 0,1056551 ! C21-steroid hormone metabolic process GO:0008207 38 21 0,000 0,07572741 0,10559479 ! ovarian follicle development GO:0001541 39 21 0,000 0,07572741 0,10553455 ! smooth muscle contraction GO:0006939 48 21 0,000 0,07572741 0,10547439 ! cellular macromolecular complex disassembly GO:0034623 44 21 0,000 0,07572741 0,10541429 ! cell structure disassembly during apoptosis GO:0006921 32 21 0,000 0,07572741 0,10535426 ! neurotransmitter metabolic process GO:0042133 39 21 0,000 0,07572741 0,10529429 ! plasma membrane fusion GO:0045026 33 21 0,000 0,07572741 0,1052344 ! positive regulation of alpha-beta T cell activation GO:0046635 38 21 0,000 0,07572741 0,10517457 ! prostaglandin metabolic process GO:0006693 43 21 0,000 0,07572741 0,10511481 GO:0006692|prostanoid metabolic process, ! regulation of vasoconstriction GO:0019229 40 21 0,000 0,07572741 0,10505512 ! sensory perception of pain GO:0019233 33 21 0,000 0,07572741 0,1049955 ! ribosomal small subunit biogenesis GO:0042274 25 21 0,000 0,07572741 0,10493595 ! diencephalon development GO:0021536 36 21 0,000 0,07572741 0,10487646 ! collagen fibril organization GO:0030199 62 21 0,000 0,07572741 0,10481704 ! negative regulation of angiogenesis GO:0016525 49 21 0,000 0,07572741 0,10475769 ! negative regulation of intracellular transport GO:0032387 44 21 0,000 0,07572741 0,1046984 ! positive regulation of inflammatory response GO:0050729 41 21 0,000 0,07572741 0,10463918 ! vitamin A metabolic process GO:0006776 35 21 0,000 0,07572741 0,10458003 ! positive regulation of osteoblast differentiation GO:0045669 52 21 0,000 0,07572741 0,10452094 ! collagen catabolic process GO:0030574 29 21 0,000 0,07572741 0,10446193 ! leukotriene biosynthetic process GO:0019370 42 21 0,000 0,07572741 0,10440298 GO:0043450|alkene biosynthetic process, ! camera-type eye morphogenesis GO:0048593 47 21 0,000 0,07572741 0,10434409 ! sperm-egg recognition GO:0035036 23 21 0,000 0,07572741 0,10428527 ! actin filament-based movement GO:0030048 47 21 0,000 0,07572741 0,10422652 ! cellular monovalent inorganic cation homeostasis GO:0030004 42 21 0,000 0,07572741 0,10416783 ! positive regulation of protein catabolic process GO:0045732 44 22 0,000 0,07918794 0,10886671 ! pteridine and derivative metabolic process GO:0042558 32 22 0,000 0,07918794 0,10880548 ! reciprocal meiotic recombination GO:0007131 44 22 0,000 0,07918794 0,10874432 ! cellular aldehyde metabolic process GO:0006081 35 22 0,000 0,07918794 0,10868322 ! positive regulation of bone remodeling GO:0046852 54 22 0,000 0,07918794 0,1086222 GO:0034105|positive regulation of tissue remodeling, ! intra-Golgi vesicle-mediated transport GO:0006891 48 22 0,000 0,07918794 0,10856124 ! microtubule-based transport GO:0010970 59 22 0,000 0,07918794 0,10850036 ! hindlimb morphogenesis GO:0035137 47 22 0,000 0,07918794 0,10843954 ! glutamate signaling pathway GO:0007215 48 22 0,000 0,07918794 0,10837879 ! inactivation of MAPK activity GO:0000188 45 22 0,000 0,07918794 0,10831811 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 56 22 0,000 0,07918794 0,10825749 ! cellular response to starvation GO:0009267 37 22 0,000 0,07918794 0,10819694 ! vacuolar transport GO:0007034 41 22 0,000 0,07918794 0,10813647 ! central nervous system neuron development GO:0021954 47 22 0,000 0,07918794 0,10807605 ! fucose metabolic process GO:0006004 44 22 0,000 0,07918794 0,10801571 ! actin polymerization or depolymerization GO:0008154 52 22 0,000 0,07918794 0,10795543 ! D-ribose metabolic process GO:0006014 36 22 0,000 0,07918794 0,10789522 ! apoptotic nuclear changes GO:0030262 34 22 0,000 0,07918794 0,10783508 ! ureteric bud development GO:0001657 50 22 0,000 0,07918794 0,10777501 ! stem cell differentiation GO:0048863 57 22 0,000 0,07918794 0,107715 ! regulation of alpha-beta T cell differentiation GO:0046637 41 22 0,000 0,07918794 0,10765506 ! cytolysis GO:0019835 27 22 0,000 0,07918794 0,10759518 ! renal system process GO:0003014 42 22 0,000 0,07918794 0,10753537 ! vasodilation GO:0042311 40 22 0,000 0,07918794 0,10747563 ! cholesterol biosynthetic process GO:0006695 39 22 0,000 0,07918794 0,10741596 ! positive regulation of locomotion GO:0040017 44 22 0,000 0,07918794 0,10735635 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! detection of chemical stimulus GO:0009593 42 22 0,000 0,07918794 0,1072968 ! positive regulation of adaptive immune response GO:0002821 42 22 0,000 0,07918794 0,10723733 ! positive regulation of intracellular transport GO:0032388 42 22 0,000 0,07918794 0,10717791 ! response to glucocorticoid stimulus GO:0051384 42 22 0,000 0,07918794 0,10711857 ! peptidyl-serine modification GO:0018209 50 22 0,000 0,07918794 0,10705929 ! regulation of cytokine secretion GO:0050707 41 22 0,000 0,07918794 0,10700008 ! sphingolipid biosynthetic process GO:0030148 45 22 0,000 0,07918794 0,10694093 ! response to cytokine stimulus GO:0034097 69 22 0,000 0,07918794 0,10688184 ! activation of JUN kinase activity GO:0007257 47 22 0,000 0,07918794 0,10682283 ! terpenoid metabolic process GO:0006721 40 22 0,000 0,07918794 0,10676387 ! somatic diversification of immunoglobulins GO:0016445 55 22 0,000 0,07918794 0,10670498 ! gut development GO:0048565 44 22 0,000 0,07918794 0,10664616 ! pyrimidine nucleotide biosynthetic process GO:0006221 37 22 0,000 0,07918794 0,1065874 ! inner ear receptor cell differentiation GO:0060113 42 22 0,000 0,07918794 0,10652871 ! regulation of anti-apoptosis GO:0045767 62 23 0,000 0,08263561 0,11110555 ! sulfur amino acid metabolic process GO:0000096 48 23 0,000 0,08263561 0,11104444 ! gluconeogenesis GO:0006094 38 23 0,000 0,08263561 0,11098339 ! glycerol metabolic process GO:0006071 40 23 0,000 0,08263561 0,11092241 ! viral genome replication GO:0019079 44 23 0,000 0,08263561 0,1108615 ! nucleotide-excision repair, DNA damage removal GO:0000718 36 23 0,000 0,08263561 0,11080065 ! glucosamine metabolic process GO:0006041 31 23 0,000 0,08263561 0,11073987 GO:0006044|N-acetylglucosamine metabolic process, ! regulation of chemotaxis GO:0050920 45 23 0,000 0,08263561 0,11067916 ! regulation of receptor-mediated endocytosis GO:0048259 32 23 0,000 0,08263561 0,11061851 ! regeneration GO:0031099 42 23 0,000 0,08263561 0,11055793 ! axis specification GO:0009798 43 23 0,000 0,08263561 0,11049742 ! visual behavior GO:0007632 46 23 0,000 0,08263561 0,11043697 ! regulation of DNA recombination GO:0000018 51 23 0,000 0,08263561 0,11037659 ! response to ethanol GO:0045471 47 23 0,000 0,08263561 0,11031628 ! photoreceptor cell maintenance GO:0045494 41 23 0,000 0,08263561 0,11025603 ! activation of pro-apoptotic gene products GO:0008633 51 23 0,000 0,08263561 0,11019584 ! deoxyribonucleotide metabolic process GO:0009262 37 23 0,000 0,08263561 0,11013573 ! peroxisome organization GO:0007031 43 23 0,000 0,08263561 0,11007567 ! lysosome organization GO:0007040 47 23 0,000 0,08263561 0,11001569 ! cellular response to reactive oxygen species GO:0034614 35 23 0,000 0,08263561 0,10995577 ! vesicle targeting GO:0006903 49 23 0,000 0,08263561 0,10989591 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 49 23 0,000 0,08263561 0,10983612 ! cardiac muscle tissue morphogenesis GO:0055008 37 23 0,000 0,08263561 0,10977639 GO:0060415|muscle tissue morphogenesis, ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 40 23 0,000 0,08263561 0,10971673 ! regulation of interleukin-6 production GO:0032675 31 23 0,000 0,08263561 0,10965713 ! regulation of Rho GTPase activity GO:0032319 56 23 0,000 0,08263561 0,1095976 ! DNA modification GO:0006304 36 23 0,000 0,08263561 0,10953814 ! fatty acid transport GO:0015908 47 23 0,000 0,08263561 0,10947873 ! negative regulation of Wnt receptor signaling pathway GO:0030178 44 23 0,000 0,08263561 0,1094194 ! regulation of bone mineralization GO:0030500 54 23 0,000 0,08263561 0,10936012 ! nerve-nerve synaptic transmission GO:0007270 59 23 0,000 0,08263561 0,10930091 ! hormone transport GO:0009914 41 23 0,000 0,08263561 0,10924177 ! cell-cell recognition GO:0009988 28 23 0,000 0,08263561 0,10918269 ! negative regulation of cytokine production GO:0001818 41 23 0,000 0,08263561 0,10912367 ! acetyl-CoA catabolic process GO:0046356 37 23 0,000 0,08263561 0,10906471 GO:0006099|tricarboxylic acid cycle, ! response to molecule of bacterial origin GO:0002237 40 23 0,000 0,08263561 0,10900582 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 61 24 0,000 0,08607046 0,11347552 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 38 24 0,000 0,08607046 0,11341431 ! membrane lipid biosynthetic process GO:0046467 47 24 0,000 0,08607046 0,11335317 ! protein amino acid O-linked glycosylation GO:0006493 45 24 0,000 0,08607046 0,1132921 ! post-Golgi vesicle-mediated transport GO:0006892 62 24 0,000 0,08607046 0,11323109 ! glycosaminoglycan biosynthetic process GO:0006024 51 24 0,000 0,08607046 0,11317015 ! mechanoreceptor differentiation GO:0042490 48 24 0,000 0,08607046 0,11310927 ! immune response-activating cell surface receptor signaling pathway GO:0002429 49 24 0,000 0,08607046 0,11304846 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! central nervous system neuron differentiation GO:0021953 51 24 0,000 0,08607046 0,11298771 ! purine ribonucleoside metabolic process GO:0046128 38 24 0,000 0,08607046 0,11292703 GO:0042278|purine nucleoside metabolic process, ! positive regulation of cytoskeleton organization GO:0051495 52 24 0,000 0,08607046 0,11286642 ! response to corticosteroid stimulus GO:0031960 46 24 0,000 0,08607046 0,11280587 ! barbed-end actin filament capping GO:0051016 58 24 0,000 0,08607046 0,11274538 GO:0051693|actin filament capping, ! regulation of viral reproduction GO:0050792 41 24 0,000 0,08607046 0,11268496 ! positive regulation of leukocyte mediated immunity GO:0002705 47 24 0,000 0,08607046 0,1126246 GO:0002708|positive regulation of lymphocyte mediated immunity, ! leukotriene metabolic process GO:0006691 47 24 0,000 0,08607046 0,11256431 ! glycosphingolipid metabolic process GO:0006687 44 24 0,000 0,08607046 0,11250408 ! regulation of tumor necrosis factor production GO:0032680 37 24 0,000 0,08607046 0,11244392 ! membrane depolarization GO:0051899 45 24 0,000 0,08607046 0,11238382 ! pallium development GO:0021543 56 24 0,000 0,08607046 0,11232379 ! oogenesis GO:0048477 44 24 0,000 0,08607046 0,11226382 ! synaptic vesicle transport GO:0048489 52 24 0,000 0,08607046 0,11220391 ! detection of biotic stimulus GO:0009595 34 24 0,000 0,08607046 0,11214407 ! platelet activation GO:0030168 41 24 0,000 0,08607046 0,11208429 ! aromatic amino acid family metabolic process GO:0009072 37 24 0,000 0,08607046 0,11202458 ! glutamine family amino acid catabolic process GO:0009065 45 24 0,000 0,08607046 0,11196493 ! aspartate family amino acid metabolic process GO:0009066 47 24 0,000 0,08607046 0,11190534 ! porphyrin metabolic process GO:0006778 50 24 0,000 0,08607046 0,11184582 GO:0033013|tetrapyrrole metabolic process, ! pyrimidine nucleoside metabolic process GO:0006213 34 24 0,000 0,08607046 0,11178636 ! negative regulation of catabolic process GO:0009895 52 24 0,000 0,08607046 0,11172696 ! regulation of amine transport GO:0051952 41 24 0,000 0,08607046 0,11166762 ! protein import into nucleus, translocation GO:0000060 51 25 0,000 0,08949255 0,11604581 ! regulation of transmembrane transport GO:0034762 39 25 0,000 0,08949255 0,11598424 ! leukocyte adhesion GO:0007159 55 25 0,000 0,08949255 0,11592275 ! dicarboxylic acid metabolic process GO:0043648 48 25 0,000 0,08949255 0,11586131 ! phototransduction GO:0007602 37 25 0,000 0,08949255 0,11579995 ! keratinization GO:0031424 37 25 0,000 0,08949255 0,11573864 ! vacuole organization GO:0007033 49 25 0,000 0,08949255 0,11567741 ! polysaccharide catabolic process GO:0000272 30 25 0,000 0,08949255 0,11561623 ! negative regulation of DNA replication GO:0008156 45 25 0,000 0,08949255 0,11555513 ! receptor metabolic process GO:0043112 53 25 0,000 0,08949255 0,11549408 ! chromosome condensation GO:0030261 48 25 0,000 0,08949255 0,1154331 ! regulation of behavior GO:0050795 48 25 0,000 0,08949255 0,11537219 ! regulation of alpha-beta T cell activation GO:0046634 48 25 0,000 0,08949255 0,11531134 ! lymphocyte proliferation GO:0046651 55 25 0,000 0,08949255 0,11525055 ! regulation of biomineral formation GO:0070167 56 25 0,000 0,08949255 0,11518983 ! immunoglobulin production GO:0002377 62 25 0,000 0,08949255 0,11512917 GO:0002440|production of molecular mediator of immune response, ! positive regulation of protein secretion GO:0050714 41 25 0,000 0,08949255 0,11506858 ! leukocyte homeostasis GO:0001776 50 25 0,000 0,08949255 0,11500805 ! cellular alkene metabolic process GO:0043449 48 25 0,000 0,08949255 0,11494758 ! liver development GO:0001889 55 25 0,000 0,08949255 0,11488718 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 36 26 0,000 0,09290192 0,11920136 ! myelination GO:0042552 50 26 0,000 0,09290192 0,11913879 ! pyruvate metabolic process GO:0006090 43 26 0,000 0,09290192 0,11907628 ! aminoglycan biosynthetic process GO:0006023 53 26 0,000 0,09290192 0,11901384 ! molting cycle process GO:0022404 52 26 0,000 0,09290192 0,11895147 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! macromolecular complex disassembly GO:0032984 54 26 0,000 0,09290192 0,11888915 ! protein amino acid alkylation GO:0008213 59 26 0,000 0,09290192 0,11882691 GO:0006479|protein amino acid methylation, ! regulation of transcription factor import into nucleus GO:0042990 58 26 0,000 0,09290192 0,11876473 ! spinal cord development GO:0021510 54 26 0,000 0,09290192 0,11870261 ! regulation of smooth muscle contraction GO:0006940 48 26 0,000 0,09290192 0,11864056 ! multicellular organismal response to stress GO:0033555 61 26 0,000 0,09290192 0,11857858 ! digestive system process GO:0022600 49 26 0,000 0,09290192 0,11851666 ! vesicle docking during exocytosis GO:0006904 49 26 0,000 0,09290192 0,1184548 ! regulation of cellular ketone metabolic process GO:0010565 51 26 0,000 0,09290192 0,11839301 ! osteoblast differentiation GO:0001649 63 26 0,000 0,09290192 0,11833128 ! response to endoplasmic reticulum stress GO:0034976 46 26 0,000 0,09290192 0,11826962 ! neural crest cell development GO:0014032 59 26 0,000 0,09290192 0,11820802 GO:0014033|neural crest cell differentiation, ! coenzyme catabolic process GO:0009109 42 26 0,000 0,09290192 0,11814648 ! negative regulation of cell development GO:0010721 83 26 0,000 0,09290192 0,11808501 GO:0050768|negative regulation of neurogenesis, ! hydrogen peroxide metabolic process GO:0042743 35 26 0,000 0,09290192 0,11802361 ! ribonucleoside monophosphate metabolic process GO:0009161 45 26 0,000 0,09290192 0,11796226 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! pentose metabolic process GO:0019321 43 26 0,000 0,09290192 0,11790099 ! response to estradiol stimulus GO:0032355 43 26 0,000 0,09290192 0,11783977 ! positive regulation of MAPKKK cascade GO:0043410 50 26 0,000 0,09290192 0,11777862 ! regulation of blood coagulation GO:0030193 46 26 0,000 0,09290192 0,11771753 ! somatic diversification of immune receptors GO:0002200 63 26 0,000 0,09290192 0,1176565 ! blastocyst development GO:0001824 50 26 0,000 0,09290192 0,11759554 ! telomere organization GO:0032200 46 26 0,000 0,09290192 0,11753464 GO:0000723|telomere maintenance, ! water-soluble vitamin biosynthetic process GO:0042364 44 26 0,000 0,09290192 0,11747381 ! neural tube closure GO:0001843 58 26 0,000 0,09290192 0,11741303 GO:0060606|tube closure, ! alditol metabolic process GO:0019400 44 26 0,000 0,09290192 0,11735232 ! positive regulation of JUN kinase activity GO:0043507 59 26 0,000 0,09290192 0,11729168 ! regulation of multi-organism process GO:0043900 45 26 0,000 0,09290192 0,11723109 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 31 27 0,000 0,09629862 0,12145459 ! embryonic pattern specification GO:0009880 49 27 0,000 0,09629862 0,12139192 ! negative regulation of actin filament depolymerization GO:0030835 63 27 0,000 0,09629862 0,12132931 ! negative regulation of actin filament polymerization GO:0030837 61 27 0,000 0,09629862 0,12126677 ! regulation of interferon-gamma production GO:0032649 43 27 0,000 0,09629862 0,1212043 ! acetyl-CoA metabolic process GO:0006084 41 27 0,000 0,09629862 0,12114188 ! iron ion transport GO:0006826 65 27 0,000 0,09629862 0,12107954 ! cellular polysaccharide biosynthetic process GO:0033692 41 27 0,000 0,09629862 0,12101725 ! superoxide metabolic process GO:0006801 41 27 0,000 0,09629862 0,12095503 ! tube lumen formation GO:0035148 59 27 0,000 0,09629862 0,12089288 ! odontogenesis of dentine-containing tooth GO:0042475 54 27 0,000 0,09629862 0,12083078 ! regulation of endothelial cell proliferation GO:0001936 60 27 0,000 0,09629862 0,12076876 ! mitochondrial membrane organization GO:0007006 60 27 0,000 0,09629862 0,12070679 ! multicellular organismal catabolic process GO:0044243 38 27 0,000 0,09629862 0,12064489 ! response to starvation GO:0042594 47 27 0,000 0,09629862 0,12058305 ! response to toxin GO:0009636 49 27 0,000 0,09629862 0,12052128 ! cellular response to oxidative stress GO:0034599 43 27 0,000 0,09629862 0,12045957 ! regulation of chromosome organization GO:0033044 49 27 0,000 0,09629862 0,12039792 ! cellular response to nutrient levels GO:0031669 45 27 0,000 0,09629862 0,12033634 ! fat-soluble vitamin metabolic process GO:0006775 42 27 0,000 0,09629862 0,12027482 ! leukocyte proliferation GO:0070661 59 27 0,000 0,09629862 0,12021336 GO:0032943|mononuclear cell proliferation, ! negative regulation of lymphocyte activation GO:0051250 55 27 0,000 0,09629862 0,12015196 ! neuron fate commitment GO:0048663 52 28 0,000 0,0996827 0,12431079 ! spliceosomal snRNP biogenesis GO:0000387 40 28 0,000 0,0996827 0,12424737 ! vesicle docking GO:0048278 55 28 0,000 0,0996827 0,12418401 ! circadian rhythm GO:0007623 56 28 0,000 0,0996827 0,12412071 ! negative regulation of protein modification process GO:0031400 66 28 0,000 0,0996827 0,12405748 ! fat cell differentiation GO:0045444 57 28 0,000 0,0996827 0,12399432 ! positive regulation of innate immune response GO:0045089 49 28 0,000 0,0996827 0,12393122 ! sperm motility GO:0030317 37 28 0,000 0,0996827 0,12386818 ! vitamin biosynthetic process GO:0009110 48 28 0,000 0,0996827 0,12380521 ! base-excision repair GO:0006284 41 28 0,000 0,0996827 0,1237423 ! cyclic nucleotide biosynthetic process GO:0009190 43 28 0,000 0,0996827 0,12367945 ! regulation of systemic arterial blood pressure GO:0003073 55 28 0,000 0,0996827 0,12361667 ! positive regulation of T cell differentiation GO:0045582 48 28 0,000 0,0996827 0,12355395 ! glycolipid metabolic process GO:0006664 50 28 0,000 0,0996827 0,1234913 ! proteoglycan biosynthetic process GO:0030166 62 28 0,000 0,0996827 0,12342871 ! regulation of response to biotic stimulus GO:0002831 52 28 0,000 0,0996827 0,12336618 ! glutathione metabolic process GO:0006749 42 28 0,000 0,0996827 0,12330372 ! group transfer coenzyme metabolic process GO:0006752 53 28 0,000 0,0996827 0,12324132 ! lipid oxidation GO:0034440 48 28 0,000 0,0996827 0,12317898 GO:0019395|fatty acid oxidation, ! regulation of JUN kinase activity GO:0043506 67 28 0,000 0,0996827 0,1231167 ! negative regulation of protein polymerization GO:0032272 63 28 0,000 0,0996827 0,12305449 ! positive regulation of smooth muscle cell proliferation GO:0048661 46 29 0,000 0,1030542 0,12715223 ! translational initiation GO:0006413 66 29 0,000 0,1030542 0,12708804 ! cellular iron ion homeostasis GO:0006879 57 29 0,000 0,1030542 0,12702392 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 57 29 0,000 0,1030542 0,12695987 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! catechol metabolic process GO:0009712 55 29 0,000 0,1030542 0,12689587 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! ER-nuclear signaling pathway GO:0006984 52 29 0,000 0,1030542 0,12683195 ! autophagy GO:0006914 47 29 0,000 0,1030542 0,12676808 ! respiratory gaseous exchange GO:0007585 61 29 0,000 0,1030542 0,12670429 ! primary neural tube formation GO:0014020 61 29 0,000 0,1030542 0,12664055 ! regulation of production of molecular mediator of immune response GO:0002700 69 29 0,000 0,1030542 0,12657688 ! response to organic cyclic substance GO:0014070 58 29 0,000 0,1030542 0,12651327 ! synaptogenesis GO:0007416 46 29 0,000 0,1030542 0,12644973 ! neuromuscular process controlling balance GO:0050885 67 29 0,000 0,1030542 0,12638625 ! ethanolamine and derivative metabolic process GO:0042439 48 29 0,000 0,1030542 0,12632284 ! regulation of actin filament depolymerization GO:0030834 67 30 0,000 0,10641317 0,13037481 ! phenol metabolic process GO:0018958 56 30 0,000 0,10641317 0,13030946 ! icosanoid biosynthetic process GO:0046456 60 30 0,000 0,10641317 0,13024418 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 56 30 0,000 0,10641317 0,13017896 ! detection of light stimulus involved in sensory perception GO:0050962 42 30 0,000 0,10641317 0,1301138 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! sensory perception of taste GO:0050909 41 30 0,000 0,10641317 0,13004871 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 50 30 0,000 0,10641317 0,12998369 ! acute-phase response GO:0006953 50 30 0,000 0,10641317 0,12991873 ! complement activation, classical pathway GO:0006958 51 30 0,000 0,10641317 0,12985383 ! immune response-activating signal transduction GO:0002757 58 30 0,000 0,10641317 0,129789 GO:0002764|immune response-regulating signal transduction, ! determination of left/right symmetry GO:0007368 53 30 0,000 0,10641317 0,12972424 ! cell fate determination GO:0001709 64 30 0,000 0,10641317 0,12965954 ! positive regulation of multicellular organism growth GO:0040018 55 30 0,000 0,10641317 0,1295949 ! phospholipid transport GO:0015914 65 30 0,000 0,10641317 0,12953033 ! nicotinamide metabolic process GO:0006769 56 30 0,000 0,10641317 0,12946582 GO:0046496|nicotinamide nucleotide metabolic process, ! neurotransmitter secretion GO:0007269 55 30 0,000 0,10641317 0,12940138 ! negative regulation of transcription regulator activity GO:0090048 57 30 0,000 0,10641317 0,129337 GO:0043433|negative regulation of transcription factor activity, ! tissue homeostasis GO:0001894 50 30 0,000 0,10641317 0,12927269 GO:0048871|multicellular organismal homeostasis, ! regulation of coagulation GO:0050818 52 30 0,000 0,10641317 0,12920844 ! alkaloid metabolic process GO:0009820 57 31 0,000 0,10975966 0,13320558 ! determination of bilateral symmetry GO:0009855 55 31 0,000 0,10975966 0,13313944 GO:0009799|determination of symmetry, ! zinc ion transport GO:0006829 54 31 0,000 0,10975966 0,13307337 ! amino sugar metabolic process GO:0006040 41 31 0,000 0,10975966 0,13300736 ! cell junction assembly GO:0034329 85 31 0,000 0,10975966 0,13294142 ! regulation of innate immune response GO:0045088 57 31 0,000 0,10975966 0,13287554 ! ovulation cycle process GO:0022602 55 31 0,000 0,10975966 0,13280973 ! male gonad development GO:0008584 56 31 0,000 0,10975966 0,13274398 ! iron ion homeostasis GO:0055072 60 31 0,000 0,10975966 0,1326783 ! erythrocyte differentiation GO:0030218 62 31 0,000 0,10975966 0,13261268 ! detection of light stimulus GO:0009583 44 31 0,000 0,10975966 0,13254713 ! natural killer cell activation GO:0030101 50 31 0,000 0,10975966 0,13248164 ! ensheathment of neurons GO:0007272 64 31 0,000 0,10975966 0,13241622 GO:0008366|axon ensheathment, ! cofactor catabolic process GO:0051187 54 31 0,000 0,10975966 0,13235086 ! negative regulation of leukocyte activation GO:0002695 60 31 0,000 0,10975966 0,13228556 ! fatty acid catabolic process GO:0009062 54 31 0,000 0,10975966 0,13222033 ! eye morphogenesis GO:0048592 65 31 0,000 0,10975966 0,13215517 ! positive regulation of immune effector process GO:0002699 78 31 0,000 0,10975966 0,13209007 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 54 32 0,000 0,1130937 0,13603541 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 50 32 0,000 0,1130937 0,13596846 ! collagen metabolic process GO:0032963 49 32 0,000 0,1130937 0,13590158 ! cellular carbohydrate biosynthetic process GO:0034637 47 32 0,000 0,1130937 0,13583476 ! positive regulation of T cell proliferation GO:0042102 60 32 0,000 0,1130937 0,13576802 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 54 32 0,000 0,1130937 0,13570133 ! metanephros development GO:0001656 81 32 0,000 0,1130937 0,13563471 ! response to mechanical stimulus GO:0009612 60 32 0,000 0,1130937 0,13556816 ! regulation of protein import into nucleus GO:0042306 69 32 0,000 0,1130937 0,13550167 ! mesoderm formation GO:0001707 73 32 0,000 0,1130937 0,13543525 ! hexose biosynthetic process GO:0019319 53 32 0,000 0,1130937 0,13536889 ! ovulation cycle GO:0042698 57 32 0,000 0,1130937 0,1353026 ! BMP signaling pathway GO:0030509 71 32 0,000 0,1130937 0,13523637 ! hindbrain development GO:0030902 65 32 0,000 0,1130937 0,13517021 ! positive regulation of lymphocyte differentiation GO:0045621 56 32 0,000 0,1130937 0,13510411 ! myeloid leukocyte activation GO:0002274 53 32 0,000 0,1130937 0,13503808 ! gene silencing GO:0016458 71 32 0,000 0,1130937 0,13497211 ! regulation of pH GO:0006885 56 33 0,000 0,11641535 0,13886851 ! negative regulation of response to external stimulus GO:0032102 50 33 0,000 0,11641535 0,13880074 ! cholesterol homeostasis GO:0042632 60 33 0,000 0,11641535 0,13873303 GO:0055092|sterol homeostasis, ! pigment biosynthetic process GO:0046148 73 33 0,000 0,11641535 0,13866539 ! positive regulation of gene-specific transcription GO:0043193 70 33 0,000 0,11641535 0,13859781 ! unsaturated fatty acid biosynthetic process GO:0006636 65 33 0,000 0,11641535 0,1385303 ! response to ionizing radiation GO:0010212 74 33 0,000 0,11641535 0,13846286 ! regulation of axonogenesis GO:0050770 86 33 0,000 0,11641535 0,13839548 ! positive regulation of neurogenesis GO:0050769 72 33 0,000 0,11641535 0,13832817 ! leukocyte chemotaxis GO:0030595 55 33 0,000 0,11641535 0,13826092 GO:0060326|cell chemotaxis, ! pyridine nucleotide metabolic process GO:0019362 60 33 0,000 0,11641535 0,13819374 ! regulation of calcium ion transport GO:0051924 60 33 0,000 0,11641535 0,13812662 ! negative regulation of protein transport GO:0051224 74 33 0,000 0,11641535 0,13805957 ! establishment of vesicle localization GO:0051650 67 33 0,000 0,11641535 0,13799258 ! response to hydrogen peroxide GO:0042542 56 34 0,000 0,11972466 0,14184643 ! post-embryonic development GO:0009791 76 34 0,000 0,11972466 0,14177768 ! inner ear morphogenesis GO:0042472 51 34 0,000 0,11972466 0,14170898 ! cholesterol transport GO:0030301 62 34 0,000 0,11972466 0,14164036 ! GPI anchor biosynthetic process GO:0006506 58 34 0,000 0,11972466 0,1415718 ! spliceosome assembly GO:0000245 75 34 0,000 0,11972466 0,14150331 ! nuclear-transcribed mRNA catabolic process GO:0000956 57 34 0,000 0,11972466 0,14143489 ! regulation of ARF GTPase activity GO:0032312 73 34 0,000 0,11972466 0,14136653 ! formation of primary germ layer GO:0001704 76 34 0,000 0,11972466 0,14129823 ! cell fate specification GO:0001708 56 34 0,000 0,11972466 0,14123001 ! negative regulation of MAP kinase activity GO:0043407 78 34 0,000 0,11972466 0,14116185 ! serine family amino acid metabolic process GO:0009069 56 34 0,000 0,11972466 0,14109375 ! adult locomotory behavior GO:0008344 62 34 0,000 0,11972466 0,14102572 ! mRNA export from nucleus GO:0006406 53 35 0,000 0,12302166 0,14483948 ! negative regulation of DNA metabolic process GO:0051053 65 35 0,000 0,12302166 0,14476971 ! regulation of synaptic plasticity GO:0048167 78 35 0,000 0,12302166 0,14470001 ! proteoglycan metabolic process GO:0006029 75 35 0,000 0,12302166 0,14463038 ! membrane docking GO:0022406 69 35 0,000 0,12302166 0,14456081 ! GPI anchor metabolic process GO:0006505 61 35 0,000 0,12302166 0,14449131 ! regulation of striated muscle tissue development GO:0016202 81 35 0,000 0,12302166 0,14442188 ! multicellular organismal macromolecule metabolic process GO:0044259 54 35 0,000 0,12302166 0,14435251 ! mesoderm morphogenesis GO:0048332 80 35 0,000 0,12302166 0,14428321 ! ceramide metabolic process GO:0006672 72 35 0,000 0,12302166 0,14421398 ! telencephalon development GO:0021537 81 35 0,000 0,12302166 0,14414481 ! sterol transport GO:0015918 63 35 0,000 0,12302166 0,14407571 ! biogenic amine biosynthetic process GO:0042401 65 35 0,000 0,12302166 0,14400667 ! placenta development GO:0001890 53 35 0,000 0,12302166 0,1439377 ! vesicle localization GO:0051648 70 35 0,000 0,12302166 0,1438688 ! regulation of muscle development GO:0048634 82 36 0,000 0,12630641 0,1476395 ! mitotic sister chromatid segregation GO:0000070 63 36 0,000 0,12630641 0,1475689 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 54 36 0,000 0,12630641 0,14749836 ! negative regulation of DNA binding GO:0043392 67 36 0,000 0,12630641 0,14742789 ! positive regulation of cell development GO:0010720 85 36 0,000 0,12630641 0,14735748 ! protein targeting to membrane GO:0006612 75 36 0,000 0,12630641 0,14728714 ! regulation of proteolysis GO:0030162 77 36 0,000 0,12630641 0,14721687 ! negative regulation of hydrolase activity GO:0051346 66 36 0,000 0,12630641 0,14714667 ! aerobic respiration GO:0009060 56 36 0,000 0,12630641 0,14707653 ! cytokine production GO:0001816 68 36 0,000 0,12630641 0,14700646 ! embryonic organ development GO:0048568 67 36 0,000 0,12630641 0,14693646 ! pyrimidine nucleotide metabolic process GO:0006220 63 36 0,000 0,12630641 0,14686652 ! monosaccharide biosynthetic process GO:0046364 57 36 0,000 0,12630641 0,14679665 ! negative regulation of adenylate cyclase activity GO:0007194 64 37 0,000 0,12957895 0,15052847 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! regulation of smooth muscle cell proliferation GO:0048660 64 37 0,000 0,12957895 0,15045693 ! xenobiotic metabolic process GO:0006805 55 37 0,000 0,12957895 0,15038545 ! sister chromatid segregation GO:0000819 65 37 0,000 0,12957895 0,15031404 ! odontogenesis GO:0042476 74 37 0,000 0,12957895 0,1502427 ! cell junction organization GO:0034330 96 37 0,000 0,12957895 0,15017143 ! tissue remodeling GO:0048771 78 37 0,000 0,12957895 0,15010022 ! maintenance of protein location in cell GO:0032507 89 37 0,000 0,12957895 0,15002909 ! female gonad development GO:0008585 71 37 0,000 0,12957895 0,14995802 ! hormone biosynthetic process GO:0042446 62 37 0,000 0,12957895 0,14988701 ! androgen receptor signaling pathway GO:0030521 81 37 0,000 0,12957895 0,14981608 ! negative regulation of cell activation GO:0050866 69 37 0,000 0,12957895 0,14974521 ! meiosis I GO:0007127 74 38 0,000 0,13283932 0,15344041 ! organic anion transport GO:0015711 82 38 0,000 0,13283932 0,15336789 ! sphingoid metabolic process GO:0046519 78 38 0,000 0,13283932 0,15329545 ! embryonic skeletal system morphogenesis GO:0048704 68 38 0,000 0,13283932 0,15322307 ! cyclic nucleotide metabolic process GO:0009187 69 38 0,000 0,13283932 0,15315076 ! regulation of Wnt receptor signaling pathway GO:0030111 78 38 0,000 0,13283932 0,15307852 ! spermatid development GO:0007286 69 38 0,000 0,13283932 0,15300635 ! glycogen metabolic process GO:0005977 63 38 0,000 0,13283932 0,15293424 ! pigment metabolic process GO:0042440 87 38 0,000 0,13283932 0,1528622 ! neural tube formation GO:0001841 79 38 0,000 0,13283932 0,15279024 ! regulation of neuron projection development GO:0010975 102 39 0,000 0,13608757 0,15645268 ! regulation of metal ion transport GO:0010959 71 39 0,000 0,13608757 0,15637908 ! negative regulation of binding GO:0051100 71 39 0,000 0,13608757 0,15630556 ! mitotic cell cycle checkpoint GO:0007093 76 39 0,000 0,13608757 0,15623211 ! regulation of lymphocyte mediated immunity GO:0002706 79 39 0,000 0,13608757 0,15615873 ! nucleotide catabolic process GO:0009166 70 39 0,000 0,13608757 0,15608542 ! erythrocyte homeostasis GO:0034101 75 39 0,000 0,13608757 0,15601217 ! isoprenoid metabolic process GO:0006720 70 39 0,000 0,13608757 0,15593899 ! regulation of cell morphogenesis involved in differentiation GO:0010769 101 39 0,000 0,13608757 0,15586589 ! glucan metabolic process GO:0044042 64 39 0,000 0,13608757 0,15579285 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 62 40 0,000 0,13932374 0,15942291 GO:0006956|complement activation, ! mammary gland development GO:0030879 93 40 0,000 0,13932374 0,15934827 ! ER to Golgi vesicle-mediated transport GO:0006888 91 40 0,000 0,13932374 0,1592737 ! learning GO:0007612 82 40 0,000 0,13932374 0,15919921 ! development of primary female sexual characteristics GO:0046545 80 40 0,000 0,13932374 0,15912478 GO:0046660|female sex differentiation, ! nucleus organization GO:0006997 73 40 0,000 0,13932374 0,15905042 ! lipid homeostasis GO:0055088 75 40 0,000 0,13932374 0,15897614 ! regulation of action potential in neuron GO:0019228 80 40 0,000 0,13932374 0,15890192 ! Rho protein signal transduction GO:0007266 88 40 0,000 0,13932374 0,15882777 ! RNA export from nucleus GO:0006405 61 41 0,000 0,14254789 0,16242747 ! mRNA catabolic process GO:0006402 79 41 0,000 0,14254789 0,16235174 ! phosphoinositide biosynthetic process GO:0046489 77 41 0,000 0,14254789 0,16227609 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 75 41 0,000 0,14254789 0,16220051 ! cellular amide metabolic process GO:0043603 73 41 0,000 0,14254789 0,16212499 ! feeding behavior GO:0007631 69 41 0,000 0,14254789 0,16204955 ! multicellular organismal metabolic process GO:0044236 64 41 0,000 0,14254789 0,16197418 ! mesenchymal cell development GO:0014031 94 41 0,000 0,14254789 0,16189888 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! monovalent inorganic cation homeostasis GO:0055067 72 41 0,000 0,14254789 0,16182365 ! energy coupled proton transport, down electrochemical gradient GO:0015985 75 41 0,000 0,14254789 0,16174848 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 95 41 0,000 0,14254789 0,16167339 ! spermatid differentiation GO:0048515 73 41 0,000 0,14254789 0,16159837 ! embryonic epithelial tube formation GO:0001838 85 41 0,000 0,14254789 0,16152342 ! RNA modification GO:0009451 64 41 0,000 0,14254789 0,16144853 ! ear morphogenesis GO:0042471 64 42 0,000 0,14576004 0,16501009 ! alcohol biosynthetic process GO:0046165 65 42 0,000 0,14576004 0,16493366 ! T cell differentiation GO:0030217 93 42 0,000 0,14576004 0,16485731 ! ribonucleoside metabolic process GO:0009119 64 42 0,000 0,14576004 0,16478102 ! regulation of leukocyte mediated immunity GO:0002703 84 42 0,000 0,14576004 0,1647048 ! regulation of T cell differentiation GO:0045580 78 42 0,000 0,14576004 0,16462865 ! regulation of protein secretion GO:0050708 77 42 0,000 0,14576004 0,16455258 ! dorsal/ventral pattern formation GO:0009953 75 42 0,000 0,14576004 0,16447657 ! cytokinesis GO:0000910 84 42 0,000 0,14576004 0,16440064 ! response to xenobiotic stimulus GO:0009410 63 42 0,000 0,14576004 0,16432477 ! epithelial cell differentiation GO:0030855 83 43 0,000 0,14896025 0,16785512 ! transforming growth factor beta receptor signaling pathway GO:0007179 82 43 0,000 0,14896025 0,16777773 ! protein amino acid N-linked glycosylation GO:0006487 71 43 0,000 0,14896025 0,16770041 ! regulation of tube size GO:0035150 76 43 0,000 0,14896025 0,16762317 GO:0050880|regulation of blood vessel size, ! calcium-dependent cell-cell adhesion GO:0016339 56 43 0,000 0,14896025 0,16754599 ! glucose transport GO:0015758 66 43 0,000 0,14896025 0,16746889 ! monocarboxylic acid transport GO:0015718 93 43 0,000 0,14896025 0,16739186 ! cytoskeleton-dependent intracellular transport GO:0030705 106 43 0,000 0,14896025 0,1673149 ! development of primary male sexual characteristics GO:0046546 80 43 0,000 0,14896025 0,167238 ! regulation of T cell proliferation GO:0042129 80 43 0,000 0,14896025 0,16716118 ! ion transmembrane transport GO:0034220 79 43 0,000 0,14896025 0,16708443 ! neuron migration GO:0001764 85 43 0,000 0,14896025 0,16700775 ! response to reactive oxygen species GO:0000302 75 44 0,000 0,15214857 0,1705041 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 92 44 0,000 0,15214857 0,17042593 ! energy reserve metabolic process GO:0006112 76 44 0,000 0,15214857 0,17034782 ! positive regulation of response to external stimulus GO:0032103 88 44 0,000 0,15214857 0,17026979 ! hexose transport GO:0008645 68 44 0,000 0,15214857 0,17019182 GO:0015749|monosaccharide transport, ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 105 44 0,000 0,15214857 0,17011393 ! striated muscle contraction GO:0006941 85 44 0,000 0,15214857 0,17003611 ! phagocytosis GO:0006909 105 44 0,000 0,15214857 0,16995837 ! heterocycle biosynthetic process GO:0018130 76 44 0,000 0,15214857 0,16988069 ! double-strand break repair GO:0006302 85 44 0,000 0,15214857 0,16980308 ! receptor-mediated endocytosis GO:0006898 98 45 0,000 0,15532502 0,17326896 ! branching morphogenesis of a tube GO:0048754 102 45 0,000 0,15532502 0,17318988 ! ATP synthesis coupled electron transport GO:0042773 69 45 0,000 0,15532502 0,17311087 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! keratinocyte differentiation GO:0030216 81 45 0,000 0,15532502 0,17303193 ! biopolymer methylation GO:0043414 91 45 0,000 0,15532502 0,17295307 ! B cell differentiation GO:0030183 124 45 0,000 0,15532502 0,17287427 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 85 45 0,000 0,15532502 0,17279555 ! female gamete generation GO:0007292 71 45 0,000 0,15532502 0,1727169 ! oxidoreduction coenzyme metabolic process GO:0006733 79 45 0,000 0,15532502 0,17263832 ! developmental growth GO:0048589 88 45 0,000 0,15532502 0,17255981 ! maintenance of location in cell GO:0051651 101 45 0,000 0,15532502 0,17248138 ! activation of adenylate cyclase activity GO:0007190 94 46 0,000 0,15848967 0,17591561 ! regulation of actin filament polymerization GO:0030833 99 46 0,000 0,15848967 0,17583572 ! glycolysis GO:0006096 71 46 0,000 0,15848967 0,17575591 ! leukocyte migration GO:0050900 75 46 0,000 0,15848967 0,17567616 ! polysaccharide biosynthetic process GO:0000271 79 46 0,000 0,15848967 0,17559649 ! positive regulation of cytokine biosynthetic process GO:0042108 76 46 0,000 0,15848967 0,17551689 ! pigmentation GO:0043473 103 46 0,000 0,15848967 0,17543736 ! positive regulation of protein transport GO:0051222 80 46 0,000 0,15848967 0,17535791 ! neural tube development GO:0021915 91 47 0,000 0,16164255 0,17876539 ! regulation of JNK cascade GO:0046328 104 47 0,000 0,16164255 0,1786845 ! positive regulation of defense response GO:0031349 88 48 0,000 0,1647837 0,18207444 ! positive regulation of adenylate cyclase activity GO:0045762 104 48 0,000 0,1647837 0,18199213 ! mitochondrial transport GO:0006839 94 48 0,000 0,1647837 0,18190989 ! cellular component disassembly GO:0022411 89 48 0,000 0,1647837 0,18182772 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 108 48 0,000 0,1647837 0,18174564 ! endosome transport GO:0016197 127 48 0,000 0,1647837 0,18166362 ! vascular process in circulatory system GO:0003018 85 48 0,000 0,1647837 0,18158168 ! male sex differentiation GO:0046661 93 48 0,000 0,1647837 0,18149981 ! icosanoid metabolic process GO:0006690 92 48 0,000 0,1647837 0,18141802 ! regulation of inflammatory response GO:0050727 84 48 0,000 0,1647837 0,1813363 ! regulation of adaptive immune response GO:0002819 92 48 0,000 0,1647837 0,18125465 ! methylation GO:0032259 97 48 0,000 0,1647837 0,18117308 ! detection of stimulus involved in sensory perception GO:0050906 75 49 0,000 0,16791317 0,18453076 ! positive regulation of cyclase activity GO:0031281 106 49 0,000 0,16791317 0,18444779 ! regulation of lymphocyte differentiation GO:0045619 92 49 0,000 0,16791317 0,18436489 ! JNK cascade GO:0007254 106 49 0,000 0,16791317 0,18428207 ! protein homooligomerization GO:0051260 84 49 0,000 0,16791317 0,18419932 ! regulation of action potential GO:0001508 102 50 0,000 0,17103101 0,18753535 ! regulation of ion transport GO:0043269 86 50 0,000 0,17103101 0,18745121 ! induction of apoptosis by extracellular signals GO:0008624 99 50 0,000 0,17103101 0,18736715 ! endocrine system development GO:0035270 109 50 0,000 0,17103101 0,18728317 ! regulation of ARF protein signal transduction GO:0032012 115 50 0,000 0,17103101 0,18719926 ! activation of caspase activity GO:0006919 95 50 0,000 0,17103101 0,18711543 ! immunoglobulin mediated immune response GO:0016064 89 50 0,000 0,17103101 0,18703167 GO:0019724|B cell mediated immunity, ! regulation of gene expression, epigenetic GO:0040029 116 50 0,000 0,17103101 0,18694799 ! positive regulation of lyase activity GO:0051349 107 50 0,000 0,17103101 0,18686438 ! epidermal cell differentiation GO:0009913 87 50 0,000 0,17103101 0,18678085 ! positive regulation of cytokine production GO:0001819 94 50 0,000 0,17103101 0,18669739 ! stress-activated protein kinase signaling pathway GO:0031098 113 51 0,000 0,17413725 0,19000326 ! peptide metabolic process GO:0006518 80 51 0,000 0,17413725 0,18991844 ! detection of abiotic stimulus GO:0009582 80 51 0,000 0,17413725 0,18983369 ! negative regulation of immune system process GO:0002683 101 51 0,000 0,17413725 0,18974902 ! response to estrogen stimulus GO:0043627 98 52 0,000 0,17723194 0,19303505 ! Notch signaling pathway GO:0007219 111 52 0,000 0,17723194 0,19294903 ! morphogenesis of embryonic epithelium GO:0016331 106 52 0,000 0,17723194 0,19286308 ! cellular amino acid biosynthetic process GO:0008652 80 52 0,000 0,17723194 0,19277721 ! unsaturated fatty acid metabolic process GO:0033559 98 52 0,000 0,17723194 0,19269142 ! excretion GO:0007588 87 52 0,000 0,17723194 0,1926057 ! DNA-dependent DNA replication GO:0006261 82 52 0,000 0,17723194 0,19252006 ! RNA elongation from RNA polymerase II promoter GO:0006368 82 52 0,000 0,17723194 0,1924345 ! ribonucleoprotein complex assembly GO:0022618 104 52 0,000 0,17723194 0,19234901 ! morphogenesis of a branching structure GO:0001763 116 52 0,000 0,17723194 0,1922636 ! amino acid activation GO:0043038 98 52 0,000 0,17723194 0,19217826 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! respiratory electron transport chain GO:0022904 83 53 0,000 0,18031511 0,1954347 ! inner ear development GO:0048839 89 53 0,000 0,18031511 0,19534804 ! chromatin remodeling GO:0006338 122 53 0,000 0,18031511 0,19526145 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 90 53 0,000 0,18031511 0,19517493 ! vesicle organization GO:0016050 127 53 0,000 0,18031511 0,1950885 ! cartilage development GO:0051216 99 53 0,000 0,18031511 0,19500214 ! synapse organization GO:0050808 102 53 0,000 0,18031511 0,19491585 ! protein amino acid lipidation GO:0006497 109 54 0,000 0,18338683 0,19814861 ! neuromuscular process GO:0050905 107 54 0,000 0,18338683 0,19806101 ! embryonic skeletal system development GO:0048706 101 54 0,000 0,18338683 0,19797349 ! regulation of muscle contraction GO:0006937 94 54 0,000 0,18338683 0,19788605 ! membrane fusion GO:0006944 122 54 0,000 0,18338683 0,19779868 ! generation of a signal involved in cell-cell signaling GO:0003001 107 54 0,000 0,18338683 0,19771139 ! glutamine family amino acid metabolic process GO:0009064 85 54 0,000 0,18338683 0,19762418 ! regulation of cell shape GO:0008360 142 54 0,000 0,18338683 0,19753704 ! epithelial tube morphogenesis GO:0060562 114 54 0,000 0,18338683 0,19744998 ! RNA catabolic process GO:0006401 103 55 0,000 0,18644711 0,20065652 ! nucleoside monophosphate biosynthetic process GO:0009124 91 55 0,000 0,18644711 0,20056816 ! regulation of actin polymerization or depolymerization GO:0008064 111 55 0,000 0,18644711 0,20047988 ! cell recognition GO:0008037 98 55 0,000 0,18644711 0,20039168 ! cell maturation GO:0048469 107 55 0,000 0,18644711 0,20030356 ! regulation of protein polymerization GO:0032271 117 55 0,000 0,18644711 0,20021551 ! skeletal muscle fiber development GO:0048741 130 56 0,000 0,18949601 0,20340016 ! glucose catabolic process GO:0006007 88 56 0,000 0,18949601 0,20331083 ! regulation of protein catabolic process GO:0042176 126 56 0,000 0,18949601 0,20322158 ! RNA elongation GO:0006354 90 56 0,000 0,18949601 0,20313241 ! chloride transport GO:0006821 102 57 0,000 0,19253358 0,20629804 ! positive regulation of caspase activity GO:0043280 108 57 0,000 0,19253358 0,2062076 GO:0010952|positive regulation of peptidase activity, ! muscle fiber development GO:0048747 131 57 0,000 0,19253358 0,20611723 ! nucleotide-excision repair GO:0006289 91 57 0,000 0,19253358 0,20602695 ! regulation of actin filament length GO:0030832 118 58 0,000 0,19555984 0,20917368 ! cellular polysaccharide metabolic process GO:0044264 93 58 0,000 0,19555984 0,20908214 ! sulfur compound biosynthetic process GO:0044272 108 58 0,000 0,19555984 0,20899068 ! lipoprotein biosynthetic process GO:0042158 115 58 0,000 0,19555984 0,2088993 ! gastrulation GO:0007369 122 58 0,000 0,19555984 0,208808 ! cellular amino acid derivative biosynthetic process GO:0042398 100 58 0,000 0,19555984 0,20871677 ! regulation of neurotransmitter levels GO:0001505 113 60 0,000 0,20157864 0,21504656 ! DNA catabolic process GO:0006308 94 60 0,000 0,20157864 0,21495269 ! heterocycle catabolic process GO:0046700 100 60 0,000 0,20157864 0,21485891 ! adult behavior GO:0030534 104 60 0,000 0,20157864 0,21476521 ! kidney development GO:0001822 133 60 0,000 0,20157864 0,21467159 ! regulation of cellular component size GO:0032535 125 61 0,000 0,20457126 0,21776365 ! regulation of Rab protein signal transduction GO:0032483 109 61 0,000 0,20457126 0,21766881 GO:0032313|regulation of Rab GTPase activity, ! glycosaminoglycan metabolic process GO:0030203 108 61 0,000 0,20457126 0,21757405 ! regulation of heart contraction GO:0008016 123 61 0,000 0,20457126 0,21747937 ! camera-type eye development GO:0043010 126 61 0,000 0,20457126 0,21738477 ! proton transport GO:0015992 117 61 0,000 0,20457126 0,21729025 ! negative regulation of response to stimulus GO:0048585 106 61 0,000 0,20457126 0,21719582 ! nucleoside metabolic process GO:0009116 91 62 0,000 0,20755274 0,22026557 ! tRNA processing GO:0008033 102 62 0,000 0,20755274 0,22016993 ! mesoderm development GO:0007498 128 63 0,000 0,21052314 0,22322397 ! skeletal system morphogenesis GO:0048705 118 63 0,000 0,21052314 0,22312712 ! water-soluble vitamin metabolic process GO:0006767 107 63 0,000 0,21052314 0,22303036 ! hydrogen transport GO:0006818 121 64 0,000 0,21348248 0,22606749 ! glycerophospholipid biosynthetic process GO:0046474 116 64 0,000 0,21348248 0,22596954 ! oxygen and reactive oxygen species metabolic process GO:0006800 99 65 0,000 0,21643081 0,22899111 ! lymphocyte mediated immunity GO:0002449 122 65 0,000 0,21643081 0,22889198 ! nucleoside monophosphate metabolic process GO:0009123 117 65 0,000 0,21643081 0,22879293 ! sphingolipid metabolic process GO:0006665 122 65 0,000 0,21643081 0,22869397 ! ear development GO:0043583 114 66 0,000 0,21936817 0,23169756 ! regulation of cytokine biosynthetic process GO:0042035 108 66 0,000 0,21936817 0,23159743 ! gonad development GO:0008406 115 66 0,000 0,21936817 0,23149739 ! embryonic limb morphogenesis GO:0030326 139 67 0,000 0,22229461 0,23448434 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 113 67 0,000 0,22229461 0,23438314 ! fatty acid biosynthetic process GO:0006633 139 67 0,000 0,22229461 0,23428202 ! secondary metabolic process GO:0019748 125 67 0,000 0,22229461 0,23418099 ! regulation of cellular response to stress GO:0080135 142 68 0,000 0,22521015 0,23715017 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 116 68 0,000 0,22521015 0,237048 ! hexose catabolic process GO:0019320 113 68 0,000 0,22521015 0,23694591 ! extracellular matrix organization GO:0030198 146 68 0,000 0,22521015 0,23684391 ! negative regulation of ligase activity GO:0051352 116 68 0,000 0,22521015 0,236742 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! detection of external stimulus GO:0009581 102 68 0,000 0,22521015 0,23664017 ! positive regulation of T cell activation GO:0050870 124 68 0,000 0,22521015 0,23653844 ! adaptive immune response GO:0002250 126 68 0,000 0,22521015 0,23643679 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 114 68 0,000 0,22521015 0,23633523 ! cellular hormone metabolic process GO:0034754 120 69 0,000 0,22811485 0,23928063 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 116 69 0,000 0,22811485 0,23917793 ! homeostasis of number of cells GO:0048872 131 69 0,000 0,22811485 0,23907532 ! cellular amino acid catabolic process GO:0009063 120 69 0,000 0,22811485 0,2389728 ! developmental maturation GO:0021700 128 69 0,000 0,22811485 0,23887037 ! single fertilization GO:0007338 83 69 0,000 0,22811485 0,23876803 ! cell redox homeostasis GO:0045454 114 70 0,000 0,23100874 0,24169351 ! germ cell development GO:0007281 133 70 0,000 0,23100874 0,24159005 ! activation of immune response GO:0002253 120 70 0,000 0,23100874 0,24148667 ! protein maturation by peptide bond cleavage GO:0051605 118 70 0,000 0,23100874 0,24138338 ! aminoglycan metabolic process GO:0006022 121 71 0,000 0,23389186 0,2442915 ! cAMP-mediated signaling GO:0019933 124 71 0,000 0,23389186 0,2441871 ! appendage morphogenesis GO:0035107 150 72 0,000 0,23676425 0,24708034 GO:0035108|limb morphogenesis, ! carbohydrate transport GO:0008643 114 72 0,000 0,23676425 0,24697484 ! actin filament organization GO:0007015 167 72 0,000 0,23676425 0,24686943 ! B cell activation GO:0042113 179 72 0,000 0,23676425 0,24676411 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 119 72 0,000 0,23676425 0,24665888 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 123 72 0,000 0,23676425 0,24655374 ! coenzyme biosynthetic process GO:0009108 119 72 0,000 0,23676425 0,24644869 ! membrane lipid metabolic process GO:0006643 132 72 0,000 0,23676425 0,24634373 ! regulation of MAPKKK cascade GO:0043408 157 72 0,000 0,23676425 0,24623886 ! appendage development GO:0048736 151 73 0,000 0,23962596 0,24910903 GO:0060173|limb development, ! humoral immune response GO:0006959 115 73 0,000 0,23962596 0,24900307 ! glycerolipid biosynthetic process GO:0045017 130 73 0,000 0,23962596 0,2488972 ! regulation of immune effector process GO:0002697 156 73 0,000 0,23962596 0,24879142 ! acute inflammatory response GO:0002526 118 74 0,000 0,24247701 0,25164458 ! amino acid transport GO:0006865 148 74 0,000 0,24247701 0,25153772 ! regulation of caspase activity GO:0043281 136 74 0,000 0,24247701 0,25143096 ! transition metal ion transport GO:0000041 143 75 0,000 0,24531746 0,25426837 ! phosphoinositide-mediated signaling GO:0048015 141 75 0,000 0,24531746 0,25416054 ! leukocyte mediated immunity GO:0002443 136 75 0,000 0,24531746 0,2540528 ! eye development GO:0001654 155 75 0,000 0,24531746 0,25394515 ! axon guidance GO:0007411 162 75 0,000 0,24531746 0,25383759 ! rhythmic process GO:0048511 142 75 0,000 0,24531746 0,25373012 ! regulation of actin cytoskeleton organization GO:0032956 167 76 0,000 0,24814733 0,25654842 ! learning or memory GO:0007611 161 76 0,000 0,24814733 0,2564399 ! elevation of cytosolic calcium ion concentration GO:0007204 147 76 0,000 0,24814733 0,25633147 ! regulation of blood pressure GO:0008217 134 76 0,000 0,24814733 0,25622313 ! lymphocyte differentiation GO:0030098 193 76 0,000 0,24814733 0,25611488 ! amine catabolic process GO:0009310 136 77 0,000 0,25096667 0,25891536 ! neurotransmitter transport GO:0006836 142 77 0,000 0,25096667 0,25880607 ! regulation of endopeptidase activity GO:0052548 141 77 0,000 0,25096667 0,25869687 ! cytosolic calcium ion homeostasis GO:0051480 149 77 0,000 0,25096667 0,25858776 ! positive regulation of ligase activity GO:0051351 130 77 0,000 0,25096667 0,25847874 ! monosaccharide catabolic process GO:0046365 125 77 0,000 0,25096667 0,25836982 ! lipoprotein metabolic process GO:0042157 147 78 0,000 0,25377552 0,26115147 ! fertilization GO:0009566 99 78 0,000 0,25377552 0,26104151 ! blood coagulation GO:0007596 151 79 0,000 0,25657391 0,26380895 GO:0050817|coagulation, ! regulation of actin filament-based process GO:0032970 170 79 0,000 0,25657391 0,26369797 ! regulation of ubiquitin-protein ligase activity GO:0051438 136 79 0,000 0,25657391 0,26358708 ! response to steroid hormone stimulus GO:0048545 147 79 0,000 0,25657391 0,26347628 ! regulation of synaptic transmission GO:0050804 159 79 0,000 0,25657391 0,26336558 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 169 80 0,000 0,25936189 0,26611554 ! activation of protein kinase activity GO:0032147 170 80 0,000 0,25936189 0,26600382 ! development of primary sexual characteristics GO:0045137 143 80 0,000 0,25936189 0,2658922 ! transcription initiation from RNA polymerase II promoter GO:0006367 136 81 0,000 0,26213949 0,26862701 ! regulation of peptidase activity GO:0052547 150 82 0,000 0,26490676 0,27134893 ! protein import into nucleus GO:0006606 174 82 0,000 0,26490676 0,27123521 ! regulation of adenylate cyclase activity GO:0045761 165 83 0,000 0,26766372 0,27394322 ! exocytosis GO:0006887 153 83 0,000 0,26766372 0,2738285 ! response to drug GO:0042493 149 83 0,000 0,26766372 0,27371388 ! cellular lipid catabolic process GO:0044242 150 83 0,000 0,26766372 0,27359936 ! intracellular protein transmembrane transport GO:0065002 165 83 0,000 0,26766372 0,27348493 ! nuclear import GO:0051170 177 83 0,000 0,26766372 0,2733706 ! inorganic anion transport GO:0015698 156 83 0,000 0,26766372 0,27325636 ! T cell activation GO:0042110 189 84 0,000 0,27041042 0,27594514 ! response to nutrient GO:0007584 135 84 0,000 0,27041042 0,27582992 ! digestion GO:0007586 130 84 0,000 0,27041042 0,2757148 ! regulation of ligase activity GO:0051340 147 84 0,000 0,27041042 0,27559977 ! hemostasis GO:0007599 165 85 0,000 0,2731469 0,27827267 ! cholesterol metabolic process GO:0008203 148 85 0,000 0,2731469 0,27815668 ! regulation of cyclase activity GO:0031279 168 85 0,000 0,2731469 0,27804078 ! regulation of transmission of nerve impulse GO:0051969 167 85 0,000 0,2731469 0,27792497 ! regulation of cAMP biosynthetic process GO:0030817 173 86 0,000 0,27587318 0,28058209 ! regulation of lyase activity GO:0051339 169 86 0,000 0,27587318 0,28046533 ! neuropeptide signaling pathway GO:0007218 125 87 0,000 0,27858932 0,28310887 ! mitochondrion organization GO:0007005 159 87 0,000 0,27858932 0,28299115 ! alcohol catabolic process GO:0046164 142 87 0,000 0,27858932 0,28287353 ! nucleosome assembly GO:0006334 126 87 0,000 0,27858932 0,28275601 ! cellular respiration GO:0045333 143 88 0,000 0,28129535 0,28538395 ! amine biosynthetic process GO:0009309 146 88 0,000 0,28129535 0,28526548 ! sensory perception of smell GO:0007608 117 88 0,000 0,28129535 0,28514711 ! chromatin assembly GO:0031497 128 88 0,000 0,28129535 0,28502884 ! one-carbon metabolic process GO:0006730 167 88 0,000 0,28129535 0,28491067 ! regulation of cAMP metabolic process GO:0030814 182 89 0,000 0,2839913 0,28752207 ! tube morphogenesis GO:0035239 194 89 0,000 0,2839913 0,28740296 ! cellular defense response GO:0006968 123 89 0,000 0,2839913 0,28728396 ! protein localization in nucleus GO:0034504 192 89 0,000 0,2839913 0,28716505 ! regulation of neurological system process GO:0031644 175 89 0,000 0,2839913 0,28704624 ! oxidative phosphorylation GO:0006119 152 90 0,000 0,28667722 0,28964121 ! regulation of nucleotide biosynthetic process GO:0030808 183 91 0,000 0,28935314 0,29222394 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! defense response to bacterium GO:0042742 112 91 0,000 0,28935314 0,29210319 ! protein-DNA complex assembly GO:0065004 134 92 0,000 0,29201909 0,29467271 ! regulation of cell morphogenesis GO:0022604 243 93 0,000 0,29467512 0,2972301 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 165 93 0,000 0,29467512 0,29710743 GO:0010498|proteasomal protein catabolic process, ! amine transport GO:0015837 181 93 0,000 0,29467512 0,29698486 ! vitamin metabolic process GO:0006766 153 93 0,000 0,29467512 0,29686239 ! nitrogen compound catabolic process GO:0044270 167 94 0,000 0,29732125 0,29940471 ! female pregnancy GO:0007565 166 94 0,000 0,29732125 0,29928134 ! carbohydrate biosynthetic process GO:0016051 158 94 0,000 0,29732125 0,29915808 ! regulation of membrane potential GO:0042391 179 94 0,000 0,29732125 0,29903492 ! regulation of defense response GO:0031347 171 95 0,000 0,29995754 0,30156225 ! nucleosome organization GO:0034728 143 95 0,000 0,29995754 0,3014382 ! phospholipid biosynthetic process GO:0008654 188 95 0,000 0,29995754 0,30131425 ! regulation of cyclic nucleotide metabolic process GO:0030799 194 95 0,000 0,29995754 0,30119041 ! ATP biosynthetic process GO:0006754 197 95 0,000 0,29995754 0,30106667 ! cofactor biosynthetic process GO:0051188 161 95 0,000 0,29995754 0,30094302 ! negative regulation of multicellular organismal process GO:0051241 174 95 0,000 0,29995754 0,30081948 ! regulation of T cell activation GO:0050863 175 96 0,000 0,302584 0,30332898 ! biogenic amine metabolic process GO:0006576 162 97 0,000 0,30520069 0,30582662 ! transcription initiation GO:0006352 171 97 0,000 0,30520069 0,30570123 ! forebrain development GO:0030900 210 98 0,000 0,30780763 0,30818609 ! regulation of nucleotide metabolic process GO:0006140 197 98 0,000 0,30780763 0,30805983 ! mRNA transport GO:0051028 185 100 0,000 0,31299243 0,3131206 ! positive regulation of immune response GO:0050778 175 100 0,000 0,31299243 0,31299243