pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6220-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! regulation of protein export from nucleus GO:0046825 6 6 4,000 1,144E-12 2,631E-09 ! negative regulation of peptide secretion GO:0002792 6 5 3,000 3,472E-10 3,992E-07 GO:0046676|negative regulation of insulin secretion, ! regulation of lipid kinase activity GO:0043550 12 7 3,000 2,42E-09 1,855E-06 ! organ growth GO:0035265 11 7 3,000 2,42E-09 1,391E-06 ! regulation of growth hormone secretion GO:0060123 11 7 3,000 2,42E-09 1,113E-06 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 3,000 4,828E-09 1,851E-06 ! nucleosome disassembly GO:0006337 12 8 3,000 4,828E-09 1,586E-06 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! positive regulation of MAP kinase activity GO:0043406 121 85 6,000 5,599E-09 1,61E-06 ! regulation of histone modification GO:0031056 11 9 3,000 8,672E-09 2,216E-06 ! regulation of chromosome organization GO:0033044 35 25 4,000 9,708E-09 2,233E-06 ! activation of MAPK activity GO:0000187 84 59 5,000 2,054E-08 4,295E-06 ! DNA damage checkpoint GO:0000077 53 31 4,000 3,063E-08 5,871E-06 ! negative regulation of secretion GO:0051048 49 31 4,000 3,063E-08 5,419E-06 ! carbohydrate homeostasis GO:0033500 39 33 4,000 4,26E-08 6,998E-06 GO:0042593|glucose homeostasis, ! DNA integrity checkpoint GO:0031570 57 34 4,000 4,983E-08 7,64E-06 ! regulation of intracellular protein transport GO:0033157 59 35 4,000 5,8E-08 8,338E-06 ! cellular response to hormone stimulus GO:0032870 109 74 5,000 8,165E-08 1,105E-05 ! negative regulation of hormone secretion GO:0046888 20 15 3,000 9,272E-08 1,185E-05 ! regulation of protein transport GO:0051223 114 76 5,000 9,592E-08 1,161E-05 GO:0070201|regulation of establishment of protein localization, ! regulation of nucleocytoplasmic transport GO:0046822 70 42 4,000 1,496E-07 1,721E-05 ! positive regulation of hormone secretion GO:0046887 24 17 3,000 1,609E-07 1,763E-05 ! cellular macromolecular complex disassembly GO:0034623 29 17 3,000 1,609E-07 1,683E-05 ! regulation of protein localization GO:0032880 132 85 5,000 1,88E-07 1,88E-05 ! nuclear migration GO:0007097 10 5 2,000 2,472E-07 2,369E-05 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 2,472E-07 2,274E-05 GO:0031272|regulation of pseudopodium assembly, ! peptidyl-amino acid modification GO:0018193 147 93 5,000 3,218E-07 2,847E-05 ! regulation of intracellular transport GO:0032386 78 49 4,000 3,302E-07 2,813E-05 ! regulation of multicellular organism growth GO:0040014 65 50 4,000 3,66E-07 3,007E-05 ! regulation of insulin secretion GO:0050796 26 21 3,000 4,012E-07 3,182E-05 ! macromolecular complex disassembly GO:0032984 38 22 3,000 4,893E-07 3,751E-05 ! ER overload response GO:0006983 7 6 2,000 4,933E-07 3,66E-05 ! macrophage differentiation GO:0030225 10 6 2,000 4,933E-07 3,546E-05 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 3,000 5,91E-07 4,119E-05 ! DNA damage response, signal transduction GO:0042770 96 56 4,000 6,511E-07 4,404E-05 ! regulation of peptide secretion GO:0002791 34 25 3,000 8,406E-07 5,524E-05 ! peptidyl-tyrosine modification GO:0018212 37 25 3,000 8,406E-07 5,37E-05 ! establishment of nucleus localization GO:0040023 13 7 2,000 8,615E-07 5,355E-05 ! negative regulation of protein modification process GO:0031400 50 26 3,000 9,912E-07 5,999E-05 ! cell cycle checkpoint GO:0000075 108 64 4,000 1,277E-06 7,528E-05 ! triglyceride metabolic process GO:0006641 34 28 3,000 1,352E-06 7,771E-05 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 2,000 1,376E-06 7,716E-05 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,376E-06 7,533E-05 ! nucleus localization GO:0051647 15 9 2,000 2,059E-06 1,101E-04 ! negative regulation of organelle organization GO:0010639 115 72 4,000 2,301E-06 1,203E-04 ! neutral lipid metabolic process GO:0006638 41 32 3,000 2,353E-06 1,203E-04 GO:0006639|acylglycerol metabolic process, ! negative regulation of transport GO:0051051 116 73 4,000 2,465E-06 1,232E-04 ! regulation of cell projection assembly GO:0060491 20 10 2,000 2,935E-06 1,436E-04 ! glycerol ether metabolic process GO:0006662 44 34 3,000 3,021E-06 1,448E-04 ! regulation of hormone secretion GO:0046883 48 36 3,000 3,821E-06 1,793E-04 ! organic ether metabolic process GO:0018904 46 36 3,000 3,821E-06 1,757E-04 ! hormone-mediated signaling GO:0009755 49 36 3,000 3,821E-06 1,723E-04 ! filopodium assembly GO:0046847 19 11 2,000 4,027E-06 1,781E-04 ! microspike assembly GO:0030035 23 12 2,000 5,359E-06 2,325E-04 ! cellular component disassembly GO:0022411 64 42 3,000 7,165E-06 3,052E-04 ! regulation of cell projection organization GO:0031344 83 44 3,000 8,652E-06 3,618E-04 ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 1,101E-05 4,523E-04 ! positive regulation of secretion GO:0051047 71 51 3,000 1,568E-05 6,328E-04 ! establishment of organelle localization GO:0051656 85 52 3,000 1,695E-05 6,723E-04 ! cell projection assembly GO:0030031 76 53 3,000 1,83E-05 7,133E-04 ! regulation of lipid metabolic process GO:0019216 84 56 3,000 2,28E-05 8,74E-04 ! multicellular organism reproduction GO:0032504 83 57 3,000 2,447E-05 9,225E-04 GO:0048609|reproductive process in a multicellular organism, ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 3,179E-05 1,179E-03 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 3,179E-05 1,16E-03 ! organelle localization GO:0051640 96 62 3,000 3,417E-05 1,228E-03 ! protein tetramerization GO:0051262 39 22 2,000 3,673E-05 1,3E-03 ! myelination GO:0042552 35 23 2,000 4,215E-05 1,469E-03 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 4,215E-05 1,447E-03 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 4,807E-05 1,626E-03 ! insulin receptor signaling pathway GO:0008286 40 24 2,000 4,807E-05 1,602E-03 ! positive regulation of nuclear division GO:0051785 39 25 2,000 5,451E-05 1,791E-03 GO:0045840|positive regulation of mitosis, ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 7,715E-05 2,499E-03 ! ensheathment of neurons GO:0007272 43 28 2,000 7,715E-05 2,465E-03 GO:0008366|axon ensheathment, ! gland development GO:0048732 148 77 3,000 8,022E-05 2,528E-03 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 1,000 8,628E-05 2,682E-03 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 1,000 8,628E-05 2,646E-03 ! cerebral cortex radially oriented cell migration GO:0021799 8 5 1,000 8,628E-05 2,611E-03 ! positive regulation of glycolysis GO:0045821 11 5 1,000 8,628E-05 2,577E-03 ! microvillus organization GO:0032528 7 5 1,000 8,628E-05 2,544E-03 GO:0030033|microvillus assembly, ! regulation of respiratory burst GO:0060263 8 5 1,000 8,628E-05 2,512E-03 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 1,000 8,628E-05 2,481E-03 GO:0022011|myelination in the peripheral nervous system, ! chromatin assembly GO:0031497 102 80 3,000 9,314E-05 2,645E-03 GO:0006334|nucleosome assembly, ! mammary gland development GO:0030879 57 31 2,000 1,052E-04 2,951E-03 ! protein-DNA complex assembly GO:0065004 107 84 3,000 1,126E-04 3,121E-03 ! peripheral nervous system development GO:0007422 53 32 2,000 1,158E-04 3,172E-03 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 1,272E-04 3,441E-03 ! nucleosome organization GO:0034728 114 87 3,000 1,291E-04 3,452E-03 ! regulation of helicase activity GO:0051095 11 6 1,000 1,292E-04 3,415E-03 ! neuron adhesion GO:0007158 9 6 1,000 1,292E-04 3,376E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 1,000 1,292E-04 3,338E-03 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,292E-04 3,301E-03 ! male sex determination GO:0030238 9 6 1,000 1,292E-04 3,265E-03 ! astrocyte development GO:0014002 14 6 1,000 1,292E-04 3,229E-03 ! Schwann cell development GO:0014044 14 6 1,000 1,292E-04 3,195E-03 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,292E-04 3,161E-03 ! axonal fasciculation GO:0007413 9 6 1,000 1,292E-04 3,127E-03 ! establishment or maintenance of cell polarity GO:0007163 61 34 2,000 1,392E-04 3,334E-03 ! cellular response to insulin stimulus GO:0032869 52 34 2,000 1,392E-04 3,3E-03 ! regulation of neurogenesis GO:0050767 153 89 3,000 1,41E-04 3,309E-03 ! leukocyte differentiation GO:0002521 143 90 3,000 1,472E-04 3,42E-03 ! hormone metabolic process GO:0042445 121 90 3,000 1,472E-04 3,386E-03 ! regulation of action potential in neuron GO:0019228 54 35 2,000 1,519E-04 3,459E-03 ! glycogen metabolic process GO:0005977 48 35 2,000 1,519E-04 3,425E-03 ! glucan metabolic process GO:0044042 49 36 2,000 1,654E-04 3,692E-03 GO:0006073|cellular glucan metabolic process, ! cerebral cortex cell migration GO:0021795 11 7 1,000 1,805E-04 3,992E-03 ! regulation of granule cell precursor proliferation GO:0021936 11 7 1,000 1,805E-04 3,954E-03 GO:0021940|positive regulation of granule cell precursor proliferation, ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 1,000 1,805E-04 3,917E-03 ! protein heterooligomerization GO:0051291 10 7 1,000 1,805E-04 3,88E-03 ! G1 DNA damage checkpoint GO:0031571 18 7 1,000 1,805E-04 3,844E-03 ! B cell lineage commitment GO:0002326 17 7 1,000 1,805E-04 3,809E-03 ! transcription from RNA polymerase I promoter GO:0006360 12 7 1,000 1,805E-04 3,774E-03 ! T cell lineage commitment GO:0002360 12 7 1,000 1,805E-04 3,74E-03 ! synaptic vesicle endocytosis GO:0048488 16 7 1,000 1,805E-04 3,707E-03 ! response to tumor cell GO:0002347 12 7 1,000 1,805E-04 3,674E-03 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 3,000 2,127E-04 4,29E-03 ! cell proliferation in forebrain GO:0021846 10 8 1,000 2,402E-04 4,804E-03 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 1,000 2,402E-04 4,763E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 1,000 2,402E-04 4,722E-03 ! astrocyte differentiation GO:0048708 16 8 1,000 2,402E-04 4,682E-03 ! Schwann cell differentiation GO:0014037 17 8 1,000 2,402E-04 4,643E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 2,402E-04 4,604E-03 ! regulation of embryonic development GO:0045995 16 8 1,000 2,402E-04 4,566E-03 ! energy reserve metabolic process GO:0006112 59 41 2,000 2,443E-04 4,606E-03 ! mitochondrial transport GO:0006839 60 42 2,000 2,625E-04 4,909E-03 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 2,816E-04 5,224E-03 ! response to insulin stimulus GO:0032868 63 43 2,000 2,816E-04 5,182E-03 ! regulation of action potential GO:0001508 71 44 2,000 3,016E-04 5,506E-03 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 3,083E-04 5,583E-03 ! regulation of developmental growth GO:0048638 13 9 1,000 3,083E-04 5,539E-03 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 3,083E-04 5,496E-03 ! telencephalon cell migration GO:0022029 16 9 1,000 3,083E-04 5,454E-03 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 1,000 3,083E-04 5,412E-03 GO:0010469|regulation of receptor activity, ! regulation of glycolysis GO:0006110 15 9 1,000 3,083E-04 5,371E-03 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 1,000 3,083E-04 5,331E-03 ! motor axon guidance GO:0008045 14 9 1,000 3,083E-04 5,291E-03 ! positive regulation of cell cycle GO:0045787 77 45 2,000 3,225E-04 5,494E-03 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 3,225E-04 5,454E-03 ! regulation of neuron apoptosis GO:0043523 77 47 2,000 3,67E-04 6,161E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 1,000 3,846E-04 6,41E-03 ! glucan biosynthetic process GO:0009250 13 10 1,000 3,846E-04 6,364E-03 GO:0005978|glycogen biosynthetic process, ! response to X-ray GO:0010165 16 10 1,000 3,846E-04 6,318E-03 ! forebrain cell migration GO:0021885 17 10 1,000 3,846E-04 6,274E-03 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 1,000 3,846E-04 6,229E-03 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 3,846E-04 6,186E-03 GO:0043470|regulation of carbohydrate catabolic process, ! cellular polysaccharide metabolic process GO:0044264 63 48 2,000 3,906E-04 6,239E-03 ! regulation of DNA replication GO:0006275 75 48 2,000 3,906E-04 6,196E-03 ! positive regulation of growth GO:0045927 67 50 2,000 4,408E-04 6,944E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 4,674E-04 7,312E-03 ! positive regulation of cell migration GO:0030335 92 51 2,000 4,674E-04 7,263E-03 ! positive regulation of organelle organization GO:0010638 82 51 2,000 4,674E-04 7,214E-03 ! virus-host interaction GO:0019048 17 11 1,000 4,692E-04 7,194E-03 ! regulation of intracellular pH GO:0051453 17 11 1,000 4,692E-04 7,146E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 4,692E-04 7,099E-03 GO:0042130|negative regulation of T cell proliferation, ! regulation of protein complex assembly GO:0043254 81 54 2,000 5,532E-04 8,316E-03 ! regulation of mitosis GO:0007088 84 54 2,000 5,532E-04 8,262E-03 GO:0051783|regulation of nuclear division, ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 5,619E-04 8,338E-03 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 5,619E-04 8,285E-03 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! histone acetylation GO:0016573 23 12 1,000 5,619E-04 8,232E-03 ! peptidyl-lysine modification GO:0018205 18 12 1,000 5,619E-04 8,18E-03 ! response to gamma radiation GO:0010332 20 12 1,000 5,619E-04 8,128E-03 ! positive regulation of cell motion GO:0051272 99 56 2,000 6,156E-04 8,85E-03 ! response to peptide hormone stimulus GO:0043434 84 57 2,000 6,485E-04 9,264E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 1,000 6,628E-04 9,411E-03 ! regulation of cellular pH GO:0030641 20 13 1,000 6,628E-04 9,353E-03 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 6,824E-04 9,57E-03 ! myeloid cell differentiation GO:0030099 85 59 2,000 7,175E-04 0,01000092 ! limbic system development GO:0021761 25 14 1,000 7,718E-04 0,01069401 ! activation of MAPKK activity GO:0000186 21 14 1,000 7,718E-04 0,01062997 ! pituitary gland development GO:0021983 23 14 1,000 7,718E-04 0,0105667 ! cellular response to starvation GO:0009267 21 14 1,000 7,718E-04 0,01050417 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 7,718E-04 0,01044238 ! G1/S transition checkpoint GO:0031575 33 14 1,000 7,718E-04 0,01038132 ! release of cytochrome c from mitochondria GO:0001836 23 14 1,000 7,718E-04 0,01032096 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 7,718E-04 0,0102613 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 8,691E-04 0,01148804 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 8,889E-04 0,01168238 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 8,889E-04 0,011616 ! centrosome cycle GO:0007098 16 15 1,000 8,889E-04 0,01155038 ! cerebral cortex development GO:0021987 29 15 1,000 8,889E-04 0,01148549 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 8,889E-04 0,01142132 ! neuron recognition GO:0008038 22 15 1,000 8,889E-04 0,01135787 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 8,889E-04 0,01129512 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 8,889E-04 0,01123306 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! protein oligomerization GO:0051259 100 65 2,000 9,52E-04 0,01196461 ! axon guidance GO:0007411 99 66 2,000 9,952E-04 0,01244018 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 1,014E-03 0,01260558 ! protein amino acid acetylation GO:0006473 28 16 1,000 1,014E-03 0,01253781 ! glial cell development GO:0021782 24 16 1,000 1,014E-03 0,01247076 ! fructose metabolic process GO:0006000 20 16 1,000 1,014E-03 0,01240443 ! diencephalon development GO:0021536 25 16 1,000 1,014E-03 0,01233879 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 1,014E-03 0,01227385 ! regulation of neuron differentiation GO:0045664 107 67 2,000 1,04E-03 0,0125198 ! activation of protein kinase activity GO:0032147 102 69 2,000 1,132E-03 0,01356481 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 1,147E-03 0,0136681 ! neuromuscular junction development GO:0007528 23 17 1,000 1,147E-03 0,01359765 ! peptidyl-serine modification GO:0018209 27 17 1,000 1,147E-03 0,01352792 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 1,000 1,147E-03 0,0134589 ! positive regulation of DNA replication GO:0045740 29 18 1,000 1,288E-03 0,01503576 ! apoptotic mitochondrial changes GO:0008637 29 18 1,000 1,288E-03 0,01495982 ! somitogenesis GO:0001756 24 18 1,000 1,288E-03 0,01488464 ! synaptic vesicle transport GO:0048489 33 18 1,000 1,288E-03 0,01481022 ! cellular response to nutrient levels GO:0031669 27 18 1,000 1,288E-03 0,01473654 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 1,288E-03 0,01466359 ! negative regulation of T cell activation GO:0050868 25 18 1,000 1,288E-03 0,01459135 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 1,288E-03 0,01451982 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 1,437E-03 0,01611818 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 1,437E-03 0,01603994 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 1,437E-03 0,01596245 ! response to starvation GO:0042594 30 19 1,000 1,437E-03 0,01588571 ! sex determination GO:0007530 29 19 1,000 1,437E-03 0,0158097 ! positive regulation of intracellular transport GO:0032388 29 19 1,000 1,437E-03 0,01573441 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 1,593E-03 0,01736676 ! pallium development GO:0021543 38 20 1,000 1,593E-03 0,01728484 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 1,758E-03 0,01897847 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 1,000 1,758E-03 0,01888979 ! protein amino acid acylation GO:0043543 37 21 1,000 1,758E-03 0,01880193 ! cell aging GO:0007569 32 21 1,000 1,758E-03 0,01871488 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 1,758E-03 0,01862864 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 1,758E-03 0,01854319 ! regulation of cell cycle process GO:0010564 122 81 2,000 1,798E-03 0,01888636 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 1,93E-03 0,02017367 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 1,93E-03 0,02008239 ! glutamate signaling pathway GO:0007215 34 22 1,000 1,93E-03 0,01999193 ! microtubule organizing center organization GO:0031023 28 22 1,000 1,93E-03 0,01990228 GO:0051297|centrosome organization, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 1,000 1,93E-03 0,01981343 ! microtubule cytoskeleton organization GO:0000226 120 84 2,000 1,996E-03 0,02040131 ! regulation of membrane potential GO:0042391 128 85 2,000 2,064E-03 0,02101021 ! regulation of DNA metabolic process GO:0051052 135 85 2,000 2,064E-03 0,02091766 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 2,109E-03 0,02127922 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 2,109E-03 0,0211863 ! negative regulation of DNA replication GO:0008156 35 23 1,000 2,109E-03 0,02109418 ! interaction with host GO:0051701 37 23 1,000 2,109E-03 0,02100287 ! cell cycle arrest GO:0007050 150 86 2,000 2,135E-03 0,02116238 ! skeletal muscle tissue development GO:0007519 123 87 2,000 2,206E-03 0,0217786 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 2,000 2,206E-03 0,02168553 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 2,297E-03 0,02247945 ! mitochondrial membrane organization GO:0007006 39 24 1,000 2,297E-03 0,0223842 ! negative regulation of cell development GO:0010721 56 24 1,000 2,297E-03 0,02228975 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 2,297E-03 0,0221961 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 2,297E-03 0,02210323 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 1,000 2,492E-03 0,02387971 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 2,492E-03 0,02378063 ! polysaccharide metabolic process GO:0005976 129 93 2,000 2,667E-03 0,02535179 ! regulation of pH GO:0006885 36 26 1,000 2,694E-03 0,02550181 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 2,694E-03 0,02539729 ! angiogenesis GO:0001525 149 95 2,000 2,833E-03 0,02659918 ! response to ionizing radiation GO:0010212 47 27 1,000 2,904E-03 0,02715444 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 2,904E-03 0,02704451 ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 2,919E-03 0,02706857 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 3,122E-03 0,0288361 ! positive regulation of catabolic process GO:0009896 40 28 1,000 3,122E-03 0,02872075 ! regulation of axonogenesis GO:0050770 51 29 1,000 3,347E-03 0,03066702 ! telencephalon development GO:0021537 52 29 1,000 3,347E-03 0,03054533 ! spindle organization GO:0007051 37 30 1,000 3,579E-03 0,03253595 ! negative regulation of cell activation GO:0050866 44 30 1,000 3,579E-03 0,03240786 ! glial cell differentiation GO:0010001 55 31 1,000 3,819E-03 0,03444159 ! segmentation GO:0035282 41 31 1,000 3,819E-03 0,03430705 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 3,819E-03 0,03417356 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 4,065E-03 0,03624167 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 4,065E-03 0,03610174 ! meiosis I GO:0007127 52 32 1,000 4,065E-03 0,03596289 ! monovalent inorganic cation homeostasis GO:0055067 45 32 1,000 4,065E-03 0,0358251 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 4,065E-03 0,03568836 ! positive regulation of DNA metabolic process GO:0051054 54 33 1,000 4,319E-03 0,03777464 ! sister chromatid segregation GO:0000819 46 33 1,000 4,319E-03 0,03763156 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 4,319E-03 0,03748955 ! cytokinesis GO:0000910 52 33 1,000 4,319E-03 0,03734861 ! regulation of neuron projection development GO:0010975 63 34 1,000 4,581E-03 0,03945935 ! mitotic cell cycle checkpoint GO:0007093 63 34 1,000 4,581E-03 0,03931211 ! neuron migration GO:0001764 46 34 1,000 4,581E-03 0,03916597 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 1,000 4,581E-03 0,03902091 ! polysaccharide biosynthetic process GO:0000271 47 35 1,000 4,849E-03 0,04115497 ! positive regulation of transcription factor activity GO:0051091 49 36 1,000 5,125E-03 0,04333339 GO:0090047|positive regulation of transcription regulator activity, ! learning GO:0007612 67 37 1,000 5,407E-03 0,04555534 ! regulation of protein secretion GO:0050708 51 37 1,000 5,407E-03 0,04538908 ! gliogenesis GO:0042063 71 38 1,000 5,697E-03 0,04764607 ! regulation of T cell proliferation GO:0042129 58 38 1,000 5,697E-03 0,04747344 ! mesenchymal cell development GO:0014031 64 38 1,000 5,697E-03 0,04730206 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 5,993E-03 0,04958552 ! synapse organization GO:0050808 55 39 1,000 5,993E-03 0,04940779 ! induction of apoptosis by intracellular signals GO:0008629 67 40 1,000 6,297E-03 0,05172436 ! T cell differentiation GO:0030217 65 40 1,000 6,297E-03 0,05154029 ! double-strand break repair GO:0006302 67 40 1,000 6,297E-03 0,05135752 ! B cell differentiation GO:0030183 62 40 1,000 6,297E-03 0,05117605 ! JAK-STAT cascade GO:0007259 53 40 1,000 6,297E-03 0,05099585 ! positive regulation of protein transport GO:0051222 55 40 1,000 6,297E-03 0,05081692 ! positive regulation of DNA binding GO:0043388 57 41 1,000 6,607E-03 0,05313537 ! regulation of T cell differentiation GO:0045580 59 41 1,000 6,607E-03 0,05295023 ! branching morphogenesis of a tube GO:0048754 72 42 1,000 6,925E-03 0,05529985 ! positive regulation of binding GO:0051099 59 43 1,000 7,249E-03 0,05768738 ! activation of caspase activity GO:0006919 65 43 1,000 7,249E-03 0,05748846 ! glycolysis GO:0006096 53 44 1,000 7,579E-03 0,05990553 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 7,579E-03 0,05970037 ! cell recognition GO:0008037 58 45 1,000 7,917E-03 0,06214616 ! histone modification GO:0016570 68 46 1,000 8,261E-03 0,06462757 ! response to UV GO:0009411 75 46 1,000 8,261E-03 0,0644085 ! endocrine system development GO:0035270 83 47 1,000 8,612E-03 0,0669171 ! covalent chromatin modification GO:0016569 75 47 1,000 8,612E-03 0,06669179 ! negative regulation of immune system process GO:0002683 73 47 1,000 8,612E-03 0,06646799 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 8,612E-03 0,06624569 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of caspase activity GO:0043280 72 48 1,000 8,969E-03 0,06876531 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 1,000 8,969E-03 0,06853686 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 8,969E-03 0,06830991 ! regulation of angiogenesis GO:0045765 94 49 1,000 9,333E-03 0,07084756 ! morphogenesis of a branching structure GO:0001763 86 49 1,000 9,333E-03 0,07061451 ! skeletal muscle fiber development GO:0048741 73 50 1,000 9,704E-03 0,07317711 ! muscle fiber development GO:0048747 74 51 1,000 0,01008092 0,07577165 ! aging GO:0007568 79 52 1,000 0,01046436 0,07839751 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,01046436 0,07814297 ! glucose catabolic process GO:0006007 66 54 1,000 0,01125039 0,08374079 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,01125039 0,08347066 ! negative regulation of protein kinase activity GO:0006469 99 57 1,000 0,01247672 0,09227155 ! chromosome segregation GO:0007059 83 57 1,000 0,01247672 0,09197581 ! negative regulation of kinase activity GO:0033673 100 58 1,000 0,01289794 0,09477722 ! viral reproductive process GO:0022415 87 58 1,000 0,01289794 0,09447538 ! lung development GO:0030324 94 59 1,000 0,01332533 0,09729606 ! negative regulation of transferase activity GO:0051348 105 61 1,000 0,01419842 0,10334297 ! meiosis GO:0007126 96 61 1,000 0,01419842 0,10301696 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of cell growth GO:0030308 106 62 1,000 0,01464406 0,10591614 ! respiratory tube development GO:0030323 99 62 1,000 0,01464406 0,10558411 ! meiotic cell cycle GO:0051321 97 62 1,000 0,01464406 0,10525416 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01478591 0,10594265 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01478591 0,10561363 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01478591 0,10528666 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01478591 0,1049617 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01478591 0,10463874 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01478591 0,10431776 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01478591 0,10399875 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01478591 0,10368168 ! sleep GO:0030431 11 5 0,000 0,01478591 0,10336654 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01478591 0,1030533 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01478591 0,10274196 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01478591 0,1024325 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01478591 0,1021249 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01478591 0,10181913 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01478591 0,10151519 ! tongue development GO:0043586 6 5 0,000 0,01478591 0,10121307 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01478591 0,10091273 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01478591 0,10061417 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01478591 0,10031738 ! cobalt ion transport GO:0006824 9 5 0,000 0,01478591 0,10002232 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01478591 0,099729 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01478591 0,0994374 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01478591 0,09914749 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01478591 0,09885927 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01478591 0,09857273 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01478591 0,09828783 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01478591 0,09800458 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01478591 0,09772296 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01478591 0,09744295 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01478591 0,09716454 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01478591 0,09688772 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01478591 0,09661247 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01478591 0,09633878 ! malate metabolic process GO:0006108 7 5 0,000 0,01478591 0,09606664 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01478591 0,09579603 ! behavioral response to pain GO:0048266 7 5 0,000 0,01478591 0,09552694 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01478591 0,09525936 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01478591 0,09499327 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01478591 0,09472866 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! mating behavior GO:0007617 6 5 0,000 0,01478591 0,09446553 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01478591 0,09420385 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01478591 0,09394362 ! rhythmic behavior GO:0007622 12 5 0,000 0,01478591 0,09368482 ! copulation GO:0007620 7 5 0,000 0,01478591 0,09342745 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01478591 0,09317148 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01478591 0,09291691 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01478591 0,09266373 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01478591 0,09241193 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01478591 0,09216149 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01478591 0,09191241 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01478591 0,09166466 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01478591 0,09141825 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01478591 0,09117316 ! response to protozoan GO:0001562 9 5 0,000 0,01478591 0,09092939 ! lymph vessel development GO:0001945 7 5 0,000 0,01478591 0,09068691 ! endochondral ossification GO:0001958 12 5 0,000 0,01478591 0,09044572 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01478591 0,09020581 ! parathyroid gland development GO:0060017 8 5 0,000 0,01478591 0,08996717 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01478591 0,08972979 ! anagen GO:0042640 6 5 0,000 0,01478591 0,08949366 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01478591 0,08925877 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01478591 0,08902511 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01478591 0,08879266 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01478591 0,08856143 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01478591 0,0883314 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01478591 0,08810257 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01478591 0,08787491 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01478591 0,08764843 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,01478591 0,08742311 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01478591 0,08719895 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01478591 0,08697593 ! negative regulation of survival gene product expression GO:0008634 6 5 0,000 0,01478591 0,08675406 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01478591 0,08653331 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01478591 0,08631368 ! ovulation GO:0030728 6 5 0,000 0,01478591 0,08609517 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01478591 0,08587775 GO:0033135|regulation of peptidyl-serine phosphorylation, ! valine metabolic process GO:0006573 8 5 0,000 0,01478591 0,08566144 ! response to pH GO:0009268 9 5 0,000 0,01478591 0,08544621 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01478591 0,08523206 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01478591 0,08501898 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01478591 0,08480696 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01478591 0,084596 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01478591 0,08438608 ! polyol catabolic process GO:0046174 7 5 0,000 0,01478591 0,0841772 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01478591 0,08396936 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01478591 0,08376254 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01478591 0,08355673 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01478591 0,08335194 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01478591 0,08314814 ! urea metabolic process GO:0019627 6 5 0,000 0,01478591 0,08294534 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01478591 0,08274353 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01478591 0,08254269 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01478591 0,08234283 ! neutrophil activation GO:0042119 5 5 0,000 0,01478591 0,08214394 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01478591 0,081946 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01478591 0,08174902 ! response to food GO:0032094 5 5 0,000 0,01478591 0,08155297 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01478591 0,08135787 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01478591 0,0811637 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01478591 0,08097045 ! forebrain neuron development GO:0021884 7 5 0,000 0,01478591 0,08077812 ! melanosome organization GO:0032438 7 5 0,000 0,01478591 0,08058671 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01478591 0,08039619 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01478591 0,08020658 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01478591 0,08001786 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01478591 0,07983002 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01478591 0,07964307 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01478591 0,07945699 ! nucleoside transport GO:0015858 6 5 0,000 0,01478591 0,07927177 ! nucleoside salvage GO:0043174 7 5 0,000 0,01478591 0,07908742 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01478591 0,07890392 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01478591 0,07872127 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01478591 0,07853947 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01478591 0,0783585 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01478591 0,07817837 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01478591 0,07799906 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01478591 0,07782057 ! depyrimidination GO:0045008 8 5 0,000 0,01478591 0,0776429 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01478591 0,07746604 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01478591 0,07728998 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01478591 0,07711472 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01478591 0,07694025 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01478591 0,07676657 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01478591 0,07659367 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01478591 0,07642155 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01478591 0,0762502 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01478591 0,07607962 ! monocyte differentiation GO:0030224 8 5 0,000 0,01478591 0,0759098 ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01478591 0,07574074 ! centrosome duplication GO:0051298 5 5 0,000 0,01478591 0,07557242 ! response to UV-C GO:0010225 6 5 0,000 0,01478591 0,07540486 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01478591 0,07523803 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01478591 0,07507194 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01478591 0,07490659 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01478591 0,07474196 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01478591 0,07457805 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01478591 0,07441486 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01478591 0,07425238 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,01478591 0,07409061 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01478591 0,07392954 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01478591 0,07376918 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01478591 0,0736095 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01478591 0,07345052 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01478591 0,07329222 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01478591 0,0731346 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01478591 0,07297766 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01478591 0,07282139 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01478591 0,07266579 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01478591 0,07251085 ! neural tube patterning GO:0021532 6 5 0,000 0,01478591 0,07235657 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01478591 0,07220295 ! histone demethylation GO:0016577 9 5 0,000 0,01478591 0,07204998 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01478591 0,07189765 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01478591 0,07174597 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01478591 0,07159493 ! enteric nervous system development GO:0048484 8 5 0,000 0,01478591 0,07144452 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01478591 0,07129474 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01478591 0,07114559 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01478591 0,07099706 ! transcription termination GO:0006353 8 5 0,000 0,01478591 0,07084915 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01478591 0,07070185 ! plasminogen activation GO:0031639 5 5 0,000 0,01478591 0,07055517 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01478591 0,07040909 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01478591 0,07026362 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01478591 0,07011874 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01478591 0,06997447 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01478591 0,06983078 ! apical protein localization GO:0045176 6 5 0,000 0,01478591 0,06968768 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01478591 0,06954517 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01478591 0,06940325 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01478591 0,06926189 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01478591 0,06912112 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01478591 0,06898091 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01478591 0,06884128 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01478591 0,0687022 ! glial cell migration GO:0008347 10 5 0,000 0,01478591 0,06856369 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01478591 0,06842573 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01478591 0,06828833 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01478591 0,06815148 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01478591 0,06801518 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01478591 0,06787942 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01478591 0,0677442 ! neural plate development GO:0001840 6 5 0,000 0,01478591 0,06760952 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01478591 0,06747538 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01478591 0,06734176 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01478591 0,06720868 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01478591 0,06707611 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01478591 0,06694408 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01478591 0,06681255 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01478591 0,06668155 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01478591 0,06655106 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01478591 0,06642107 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01478591 0,0662916 ! spindle assembly GO:0051225 5 5 0,000 0,01478591 0,06616263 ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01478591 0,06603416 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01478591 0,06590618 ! organ regeneration GO:0031100 7 5 0,000 0,01478591 0,0657787 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01478591 0,06565172 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01478591 0,06552522 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01478591 0,06539921 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01478591 0,06527369 GO:0055081|anion homeostasis, ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,0150957 0,0665136 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 1,000 0,0150957 0,06638642 ! viral reproduction GO:0016032 92 63 1,000 0,0150957 0,06625973 ! negative regulation of cell size GO:0045792 108 64 1,000 0,0155533 0,06813827 ! hexose catabolic process GO:0019320 82 64 1,000 0,0155533 0,06800873 ! respiratory system development GO:0060541 100 64 1,000 0,0155533 0,06787968 ! regulation of caspase activity GO:0043281 97 65 1,000 0,01601684 0,06977031 ! B cell activation GO:0042113 104 65 1,000 0,01601684 0,06963841 ! regulation of endopeptidase activity GO:0052548 99 67 1,000 0,01696154 0,07360668 ! learning or memory GO:0007611 123 68 1,000 0,01744264 0,0755519 ! tRNA transcription GO:0009304 11 6 0,000 0,01771725 0,07659715 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,01771725 0,07645344 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,01771725 0,07631027 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,01771725 0,07616764 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,01771725 0,07602553 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,01771725 0,07588396 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,01771725 0,07574291 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,01771725 0,07560239 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,01771725 0,07546238 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,01771725 0,07532289 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,01771725 0,07518392 ! prostate gland development GO:0030850 9 6 0,000 0,01771725 0,07504546 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,01771725 0,07490751 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,01771725 0,07477007 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,01771725 0,07463312 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,01771725 0,07449668 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,01771725 0,07436074 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,01771725 0,07422529 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,01771725 0,07409034 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,01771725 0,07395587 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,01771725 0,07382189 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,01771725 0,0736884 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,01771725 0,07355539 ! signal peptide processing GO:0006465 8 6 0,000 0,01771725 0,07342286 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,01771725 0,0732908 ! mRNA stabilization GO:0048255 15 6 0,000 0,01771725 0,07315922 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,01771725 0,07302811 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,01771725 0,07289747 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,01771725 0,0727673 ! opsonization GO:0008228 8 6 0,000 0,01771725 0,07263759 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,01771725 0,07250834 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,01771725 0,07237955 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,01771725 0,07225122 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,01771725 0,07212334 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,01771725 0,07199591 ! photoreceptor cell development GO:0042461 10 6 0,000 0,01771725 0,07186893 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,01771725 0,0717424 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,01771725 0,07161632 ! mechanosensory behavior GO:0007638 8 6 0,000 0,01771725 0,07149068 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,01771725 0,07136547 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,01771725 0,07124071 ! response to interferon-gamma GO:0034341 12 6 0,000 0,01771725 0,07111638 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,01771725 0,07099248 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,01771725 0,07086902 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,01771725 0,07074598 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,01771725 0,07062337 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,01771725 0,07050119 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,01771725 0,07037942 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,01771725 0,07025808 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,01771725 0,07013715 ! thymic T cell selection GO:0045061 12 6 0,000 0,01771725 0,07001664 ! protein lipoylation GO:0009249 10 6 0,000 0,01771725 0,06989655 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,01771725 0,06977686 ! pigment granule organization GO:0048753 11 6 0,000 0,01771725 0,06965758 ! drug transport GO:0015893 6 6 0,000 0,01771725 0,06953871 ! cysteine metabolic process GO:0006534 7 6 0,000 0,01771725 0,06942025 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,01771725 0,06930219 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,01771725 0,06918453 ! histidine metabolic process GO:0006547 6 6 0,000 0,01771725 0,06906726 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,01771725 0,0689504 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,01771725 0,06883393 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,01771725 0,06871785 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,01771725 0,06860216 ! adenohypophysis development GO:0021984 10 6 0,000 0,01771725 0,06848687 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,01771725 0,06837196 ! hyperosmotic response GO:0006972 8 6 0,000 0,01771725 0,06825743 ! microtubule nucleation GO:0007020 10 6 0,000 0,01771725 0,06814329 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,01771725 0,06802953 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,01771725 0,06791614 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,01771725 0,06780314 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,01771725 0,06769051 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,01771725 0,06757825 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,01771725 0,06746637 ! response to dietary excess GO:0002021 7 6 0,000 0,01771725 0,06735485 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,01771725 0,06724371 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,01771725 0,06713293 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,01771725 0,06702251 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,01771725 0,06691246 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,01771725 0,06680276 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,01771725 0,06669343 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,01771725 0,06658445 ! neuron apoptosis GO:0051402 8 6 0,000 0,01771725 0,06647583 ! organic alcohol transport GO:0015850 9 6 0,000 0,01771725 0,06636757 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,01771725 0,06625965 ! T cell mediated immunity GO:0002456 12 6 0,000 0,01771725 0,06615209 ! carnitine transport GO:0015879 8 6 0,000 0,01771725 0,06604487 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,01771725 0,065938 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,01771725 0,06583148 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,01771725 0,0657253 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,01771725 0,06561946 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,01771725 0,06551396 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,01771725 0,06540881 ! parturition GO:0007567 12 6 0,000 0,01771725 0,06530398 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,01771725 0,0651995 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,01771725 0,06509534 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,01771725 0,06499152 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,01771725 0,06488803 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,01771725 0,06478487 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,01771725 0,06468204 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,01771725 0,06457953 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,01771725 0,06447735 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,01771725 0,06437549 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,01771725 0,06427395 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,01771725 0,06417273 ! interaction with symbiont GO:0051702 8 6 0,000 0,01771725 0,06407183 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,01771725 0,06397125 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,01771725 0,06387098 ! eating behavior GO:0042755 6 6 0,000 0,01771725 0,06377103 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,01771725 0,06367138 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,01771725 0,06357205 ! response to copper ion GO:0046688 9 6 0,000 0,01771725 0,06347303 ! DNA topological change GO:0006265 8 6 0,000 0,01771725 0,06337432 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,01771725 0,06327591 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,01771725 0,06317781 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,01771725 0,06308001 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,01771725 0,06298251 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,01771725 0,06288532 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,01771725 0,06278842 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,01771725 0,06269182 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,01771725 0,06259552 ! gas homeostasis GO:0033483 11 6 0,000 0,01771725 0,06249952 ! hair follicle maturation GO:0048820 7 6 0,000 0,01771725 0,06240381 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,01771725 0,06230839 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,01771725 0,06221326 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,01771725 0,06211842 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,01771725 0,06202388 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,01771725 0,06192961 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,01771725 0,06183564 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,01771725 0,06174195 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,01771725 0,06164854 ! histone ubiquitination GO:0016574 7 6 0,000 0,01771725 0,06155542 ! regulation of meiosis GO:0040020 10 6 0,000 0,01771725 0,06146257 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,01771725 0,06137001 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,01771725 0,06127772 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,01771725 0,06118571 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,01771725 0,06109398 ! membrane to membrane docking GO:0022614 12 6 0,000 0,01771725 0,06100252 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,01771725 0,06091134 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,01771725 0,06082043 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,01771725 0,06072979 ! receptor internalization GO:0031623 9 6 0,000 0,01771725 0,06063941 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,01771725 0,06054931 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,01771725 0,06045947 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,01771725 0,06036991 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,01771725 0,0602806 ! protein deubiquitination GO:0016579 8 6 0,000 0,01771725 0,06019156 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,01771725 0,06010278 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,01771725 0,06001426 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,01771725 0,05992601 ! thiamin metabolic process GO:0006772 6 6 0,000 0,01771725 0,05983801 ! midbrain development GO:0030901 6 6 0,000 0,01771725 0,05975027 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,01771725 0,05966279 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,01771725 0,05957556 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,01771725 0,05948859 ! progesterone metabolic process GO:0042448 8 6 0,000 0,01771725 0,05940187 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,01771725 0,05931541 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,01771725 0,05922919 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,01771725 0,05914323 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,01771725 0,05905752 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,01771725 0,05897205 ! adult feeding behavior GO:0008343 6 6 0,000 0,01771725 0,05888683 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,01771725 0,05880186 ! blastocyst growth GO:0001832 15 6 0,000 0,01771725 0,05871713 ! pigment granule transport GO:0051904 12 6 0,000 0,01771725 0,05863264 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,01771725 0,0585484 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,01771725 0,0584644 ! catecholamine transport GO:0051937 7 6 0,000 0,01771725 0,05838064 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,01771725 0,05829712 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,01771725 0,05821384 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,01771725 0,05813079 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,01771725 0,05804799 ! protein prenylation GO:0018342 10 6 0,000 0,01771725 0,05796541 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,01771725 0,05788308 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,01771725 0,05780097 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,01771725 0,0577191 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,01771725 0,05763746 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,01771725 0,05755605 ! response to drug GO:0042493 108 69 1,000 0,01792951 0,05816343 ! positive regulation of phosphorylation GO:0042327 102 70 1,000 0,01842212 0,0596773 ! regulation of catabolic process GO:0009894 106 70 1,000 0,01842212 0,05959337 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,01892044 0,06111941 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,01892044 0,06103369 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,01892044 0,06094821 ! regulation of peptidase activity GO:0052547 106 72 1,000 0,01942443 0,06248418 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 1,000 0,01942443 0,06239691 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 1,000 0,01942443 0,06230989 ! tube morphogenesis GO:0035239 118 73 1,000 0,01993405 0,06385558 ! mitochondrion organization GO:0007005 104 73 1,000 0,01993405 0,06376677 ! response to oxygen levels GO:0070482 137 74 1,000 0,02044926 0,06532402 ! protein import into nucleus GO:0006606 118 74 1,000 0,02044926 0,06523342 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,02064005 0,06575084 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02064005 0,0656599 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02064005 0,06556921 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02064005 0,06547877 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02064005 0,06538858 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02064005 0,06529863 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02064005 0,06520894 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02064005 0,06511949 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02064005 0,06503028 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02064005 0,06494132 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02064005 0,0648526 ! reproductive behavior GO:0019098 12 7 0,000 0,02064005 0,06476413 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02064005 0,06467589 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02064005 0,0645879 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,02064005 0,06450014 ! oligopeptide transport GO:0006857 11 7 0,000 0,02064005 0,06441263 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02064005 0,06432535 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02064005 0,0642383 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02064005 0,06415149 ! RNA methylation GO:0001510 11 7 0,000 0,02064005 0,06406492 ! pericardium development GO:0060039 8 7 0,000 0,02064005 0,06397858 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02064005 0,06389247 ! fibril organization GO:0043206 13 7 0,000 0,02064005 0,06380659 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02064005 0,06372095 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02064005 0,06363553 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 0,000 0,02064005 0,06355034 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02064005 0,06346538 ! lipoprotein transport GO:0042953 9 7 0,000 0,02064005 0,06338065 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02064005 0,06329614 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02064005 0,06321186 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02064005 0,0631278 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02064005 0,06304397 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02064005 0,06296035 ! chemosensory behavior GO:0007635 9 7 0,000 0,02064005 0,06287696 ! microtubule bundle formation GO:0001578 8 7 0,000 0,02064005 0,06279379 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02064005 0,06271084 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02064005 0,06262811 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02064005 0,06254559 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02064005 0,0624633 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02064005 0,06238122 ! reflex GO:0060004 12 7 0,000 0,02064005 0,06229935 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02064005 0,0622177 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02064005 0,06213626 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02064005 0,06205504 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02064005 0,06197403 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02064005 0,06189323 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02064005 0,06181264 ! spinal cord patterning GO:0021511 7 7 0,000 0,02064005 0,06173226 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02064005 0,06165209 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02064005 0,06157212 ! adrenal gland development GO:0030325 17 7 0,000 0,02064005 0,06149237 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02064005 0,06141282 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02064005 0,06133347 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02064005 0,06125433 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02064005 0,06117539 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02064005 0,06109666 ! endosome organization GO:0007032 10 7 0,000 0,02064005 0,06101813 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02064005 0,0609398 ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02064005 0,06086167 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02064005 0,06078375 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02064005 0,06070602 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02064005 0,06062849 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02064005 0,06055116 ! galactose metabolic process GO:0006012 10 7 0,000 0,02064005 0,06047402 ! vesicle fusion GO:0006906 15 7 0,000 0,02064005 0,06039708 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02064005 0,06032034 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,02064005 0,06024379 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02064005 0,06016743 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02064005 0,06009127 ! retinol metabolic process GO:0042572 9 7 0,000 0,02064005 0,0600153 ! behavioral fear response GO:0001662 13 7 0,000 0,02064005 0,05993953 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,02064005 0,05986394 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02064005 0,05978855 ! rRNA modification GO:0000154 12 7 0,000 0,02064005 0,05971334 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02064005 0,05963832 ! response to UV-B GO:0010224 11 7 0,000 0,02064005 0,0595635 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02064005 0,05948885 ! intermediate filament organization GO:0045109 11 7 0,000 0,02064005 0,0594144 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02064005 0,05934013 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02064005 0,05926605 ! fibrinolysis GO:0042730 9 7 0,000 0,02064005 0,05919215 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,02064005 0,05911844 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02064005 0,05904491 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02064005 0,05897156 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02064005 0,05889839 ! response to tropane GO:0014073 13 7 0,000 0,02064005 0,05882541 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02064005 0,05875261 ! melanosome localization GO:0032400 10 7 0,000 0,02064005 0,05867998 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02064005 0,05860754 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02064005 0,05853527 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02064005 0,05846318 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02064005 0,05839127 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02064005 0,05831954 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02064005 0,05824798 ! mast cell activation GO:0045576 9 7 0,000 0,02064005 0,0581766 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02064005 0,05810539 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02064005 0,05803436 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02064005 0,0579635 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02064005 0,05789281 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02064005 0,0578223 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02064005 0,05775195 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02064005 0,05768178 GO:0002714|positive regulation of B cell mediated immunity, ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02064005 0,05761178 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02064005 0,05754195 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02064005 0,05747228 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02064005 0,05740279 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,02064005 0,05733346 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02064005 0,0572643 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02064005 0,05719531 ! diuresis GO:0030146 12 7 0,000 0,02064005 0,05712648 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02064005 0,05705782 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02064005 0,05698932 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02064005 0,05692099 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02064005 0,05685282 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02064005 0,05678482 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02064005 0,05671697 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02064005 0,05664929 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02064005 0,05658177 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02064005 0,05651441 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02064005 0,05644721 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02064005 0,05638017 ! lymph node development GO:0048535 9 7 0,000 0,02064005 0,05631329 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02064005 0,05624657 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02064005 0,05618001 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02064005 0,0561136 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02064005 0,05604735 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02064005 0,05598126 ! ATP catabolic process GO:0006200 10 7 0,000 0,02064005 0,05591532 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,02064005 0,05584954 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02064005 0,05578391 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02064005 0,05571843 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02064005 0,05565311 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02064005 0,05558795 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02064005 0,05552293 ! muscle adaptation GO:0043500 12 7 0,000 0,02064005 0,05545807 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02064005 0,05539336 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02064005 0,0553288 ! retina homeostasis GO:0001895 9 7 0,000 0,02064005 0,05526438 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02064005 0,05520012 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,02064005 0,05513601 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02064005 0,05507205 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02064005 0,05500823 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02064005 0,05494457 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02064005 0,05488105 ! negative regulation of growth GO:0045926 123 75 1,000 0,02097003 0,05569407 ! nuclear import GO:0051170 121 75 1,000 0,02097003 0,05562983 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,02149632 0,05696029 ! regulation of DNA binding GO:0051101 119 77 1,000 0,02202809 0,0583022 ! carbohydrate biosynthetic process GO:0016051 97 77 1,000 0,02202809 0,05823519 ! T cell activation GO:0042110 134 79 1,000 0,02310796 0,06101986 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02355431 0,06212719 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02355431 0,06205602 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,02355431 0,06198502 ! axon extension GO:0048675 11 8 0,000 0,02355431 0,06191418 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02355431 0,0618435 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02355431 0,06177298 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02355431 0,06170263 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02355431 0,06163243 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02355431 0,06156239 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,02355431 0,06149252 ! phosphate transport GO:0006817 10 8 0,000 0,02355431 0,0614228 ! N-glycan processing GO:0006491 12 8 0,000 0,02355431 0,06135324 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02355431 0,06128383 ! UTP metabolic process GO:0046051 8 8 0,000 0,02355431 0,06121458 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02355431 0,06114549 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02355431 0,06107656 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,02355431 0,06100778 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02355431 0,06093915 ! succinate metabolic process GO:0006105 14 8 0,000 0,02355431 0,06087068 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02355431 0,06080237 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02355431 0,0607342 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 0,000 0,02355431 0,06066619 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,02355431 0,06059833 ! middle ear morphogenesis GO:0042474 9 8 0,000 0,02355431 0,06053062 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02355431 0,06046307 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02355431 0,06039566 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02355431 0,0603284 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02355431 0,0602613 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02355431 0,06019434 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02355431 0,06012753 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02355431 0,06006087 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02355431 0,05999436 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02355431 0,05992799 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02355431 0,05986178 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02355431 0,0597957 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02355431 0,05972978 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02355431 0,05966399 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,02355431 0,05959836 ! melanin metabolic process GO:0006582 12 8 0,000 0,02355431 0,05953287 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02355431 0,05946752 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02355431 0,05940231 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,02355431 0,05933725 ! macrophage activation GO:0042116 12 8 0,000 0,02355431 0,05927233 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02355431 0,05920755 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02355431 0,05914291 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,02355431 0,05907842 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02355431 0,05901406 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02355431 0,05894984 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02355431 0,05888577 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02355431 0,05882183 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02355431 0,05875803 ! ruffle organization GO:0031529 11 8 0,000 0,02355431 0,05869437 ! osteoblast development GO:0002076 13 8 0,000 0,02355431 0,05863085 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02355431 0,05856747 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02355431 0,05850422 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02355431 0,05844111 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02355431 0,05837813 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02355431 0,05831529 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02355431 0,05825259 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02355431 0,05819002 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02355431 0,05812758 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02355431 0,05806528 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02355431 0,05800311 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02355431 0,05794108 ! segment specification GO:0007379 10 8 0,000 0,02355431 0,05787917 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,02355431 0,0578174 ! cellular extravasation GO:0045123 11 8 0,000 0,02355431 0,05775576 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02355431 0,05769426 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,02355431 0,05763288 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02355431 0,05757163 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02355431 0,05751052 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02355431 0,05744953 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02355431 0,05738867 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02355431 0,05732794 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02355431 0,05726734 ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02355431 0,05720687 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02355431 0,05714653 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02355431 0,05708631 ! icosanoid secretion GO:0032309 12 8 0,000 0,02355431 0,05702622 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,02355431 0,05696625 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02355431 0,05690642 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02355431 0,0568467 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02355431 0,05678711 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02355431 0,05672765 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02355431 0,05666831 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02355431 0,0566091 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02355431 0,05655001 ! sterol catabolic process GO:0016127 9 8 0,000 0,02355431 0,05649104 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02355431 0,0564322 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02355431 0,05637347 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02355431 0,05631487 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02355431 0,05625639 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02355431 0,05619804 ! prophase GO:0051324 11 8 0,000 0,02355431 0,0561398 ! S phase GO:0051320 8 8 0,000 0,02355431 0,05608168 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02355431 0,05602369 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02355431 0,05596581 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02355431 0,05590806 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02355431 0,05585042 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02355431 0,0557929 ! hormone catabolic process GO:0042447 13 8 0,000 0,02355431 0,0557355 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02355431 0,05567822 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02355431 0,05562105 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02355431 0,05556401 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02355431 0,05550708 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02355431 0,05545026 ! regulation of telomere maintenance GO:0032204 10 8 0,000 0,02355431 0,05539357 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02355431 0,05533698 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02355431 0,05528052 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02355431 0,05522417 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02355431 0,05516793 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02355431 0,05511181 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02355431 0,0550558 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02355431 0,05499991 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02355431 0,05494413 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02355431 0,05488846 ! alcohol catabolic process GO:0046164 104 80 1,000 0,02365597 0,05506957 ! protein localization in nucleus GO:0034504 133 80 1,000 0,02365597 0,05501389 ! forebrain development GO:0030900 131 80 1,000 0,02365597 0,05495832 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,02533193 0,05879258 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,02646006 0,06134894 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,02646006 0,06128716 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,02646006 0,0612255 ! CTP metabolic process GO:0046036 9 9 0,000 0,02646006 0,06116397 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,02646006 0,06110256 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,02646006 0,06104127 ! GTP metabolic process GO:0046039 9 9 0,000 0,02646006 0,06098011 ! elastic fiber assembly GO:0048251 13 9 0,000 0,02646006 0,06091906 ! social behavior GO:0035176 14 9 0,000 0,02646006 0,06085815 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,02646006 0,06079735 ! artery development GO:0060840 19 9 0,000 0,02646006 0,06073667 GO:0048844|artery morphogenesis, ! response to pain GO:0048265 16 9 0,000 0,02646006 0,06067612 ! protein complex disassembly GO:0043241 17 9 0,000 0,02646006 0,06061568 GO:0043624|cellular protein complex disassembly, ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,02646006 0,06055537 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,02646006 0,06049517 ! lung alveolus development GO:0048286 17 9 0,000 0,02646006 0,0604351 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,02646006 0,06037514 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,02646006 0,06031531 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,02646006 0,06025559 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,02646006 0,06019599 ! ventral spinal cord development GO:0021517 11 9 0,000 0,02646006 0,06013651 ! protein targeting to ER GO:0045047 19 9 0,000 0,02646006 0,06007714 ! T cell selection GO:0045058 18 9 0,000 0,02646006 0,0600179 ! endoderm development GO:0007492 12 9 0,000 0,02646006 0,05995876 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,02646006 0,05989975 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,02646006 0,05984085 ! arginine catabolic process GO:0006527 10 9 0,000 0,02646006 0,05978207 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,02646006 0,0597234 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,02646006 0,05966485 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,02646006 0,05960641 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,02646006 0,05954809 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,02646006 0,05948988 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,02646006 0,05943178 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,02646006 0,0593738 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,02646006 0,05931593 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,02646006 0,05925817 ! mannose metabolic process GO:0006013 9 9 0,000 0,02646006 0,05920053 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,02646006 0,059143 ! receptor clustering GO:0043113 15 9 0,000 0,02646006 0,05908558 ! epithelial cell development GO:0002064 10 9 0,000 0,02646006 0,05902827 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,02646006 0,05897107 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,02646006 0,05891398 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,02646006 0,05885701 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,02646006 0,05880014 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,02646006 0,05874338 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,02646006 0,05868674 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,02646006 0,0586302 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,02646006 0,05857377 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,02646006 0,05851745 ! blastoderm segmentation GO:0007350 11 9 0,000 0,02646006 0,05846123 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,02646006 0,05840513 ! DNA ligation GO:0006266 14 9 0,000 0,02646006 0,05834913 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,02646006 0,05829324 ! response to amine stimulus GO:0014075 13 9 0,000 0,02646006 0,05823746 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,02646006 0,05818178 ! erythrocyte development GO:0048821 11 9 0,000 0,02646006 0,05812621 ! renal water homeostasis GO:0003091 14 9 0,000 0,02646006 0,05807075 ! postreplication repair GO:0006301 11 9 0,000 0,02646006 0,05801539 ! mRNA cleavage GO:0006379 13 9 0,000 0,02646006 0,05796014 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,02646006 0,05790499 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,02646006 0,05784995 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,02646006 0,05779501 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,02646006 0,05774018 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,02646006 0,05768545 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,02646006 0,05763082 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,02646006 0,0575763 ! acid secretion GO:0046717 14 9 0,000 0,02646006 0,05752188 ! musculoskeletal movement GO:0050881 11 9 0,000 0,02646006 0,05746756 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,02646006 0,05741334 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,02646006 0,05735923 ! purine base metabolic process GO:0006144 18 9 0,000 0,02646006 0,05730522 ! oocyte differentiation GO:0009994 12 9 0,000 0,02646006 0,05725131 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,02646006 0,05719751 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,02646006 0,0571438 ! spleen development GO:0048536 15 9 0,000 0,02646006 0,05709019 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,02646006 0,05703669 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,02646006 0,05698328 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,02646006 0,05692998 ! detection of calcium ion GO:0005513 13 9 0,000 0,02646006 0,05687677 ! blastocyst formation GO:0001825 12 9 0,000 0,02646006 0,05682367 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,02646006 0,05677066 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,02646006 0,05671775 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,02646006 0,05666494 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,02646006 0,05661223 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,02646006 0,05655961 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,02646006 0,0565071 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,02646006 0,05645468 ! prepulse inhibition GO:0060134 14 9 0,000 0,02646006 0,05640236 ! embryonic placenta development GO:0001892 12 9 0,000 0,02646006 0,05635013 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,02646006 0,05629801 ! insulin secretion GO:0030073 17 9 0,000 0,02646006 0,05624598 ! sequestering of metal ion GO:0051238 11 9 0,000 0,02646006 0,05619404 ! response to nicotine GO:0035094 16 9 0,000 0,02646006 0,0561422 ! establishment of cell polarity GO:0030010 12 9 0,000 0,02646006 0,05609046 ! regulation of synapse organization GO:0050807 12 9 0,000 0,02646006 0,05603881 ! localization within membrane GO:0051668 15 9 0,000 0,02646006 0,05598725 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,02647548 0,0559684 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,02705503 0,05714102 ! interphase GO:0051325 159 88 1,000 0,02822948 0,05956679 ! reproductive developmental process GO:0003006 127 89 1,000 0,02882432 0,06076621 ! regulation of T cell activation GO:0050863 128 89 1,000 0,02882432 0,06071056 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,02935734 0,06177665 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,02935734 0,06172018 ! neuron fate specification GO:0048665 11 10 0,000 0,02935734 0,06166381 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,02935734 0,06160755 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,02935734 0,06155139 ! thyroid gland development GO:0030878 19 10 0,000 0,02935734 0,06149533 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,02935734 0,06143938 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,02935734 0,06138352 ! synapsis GO:0007129 13 10 0,000 0,02935734 0,06132777 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,02935734 0,06127212 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,02935734 0,06121657 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,02935734 0,06116112 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,02935734 0,06110577 ! sulfate transport GO:0008272 12 10 0,000 0,02935734 0,06105052 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,02935734 0,06099537 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,02935734 0,06094032 ! phospholipid efflux GO:0033700 16 10 0,000 0,02935734 0,06088537 ! hippocampus development GO:0021766 19 10 0,000 0,02935734 0,06083052 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,02935734 0,06077577 ! blood vessel remodeling GO:0001974 21 10 0,000 0,02935734 0,06072111 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,02935734 0,06066656 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,02935734 0,0606121 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,02935734 0,06055774 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,02935734 0,06050347 ! pathogenesis GO:0009405 13 10 0,000 0,02935734 0,06044931 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,02935734 0,06039524 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,02935734 0,06034127 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,02935734 0,06028739 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,02935734 0,06023361 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,02935734 0,06017993 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,02935734 0,06012634 ! melanocyte differentiation GO:0030318 15 10 0,000 0,02935734 0,06007284 GO:0050931|pigment cell differentiation, ! polyamine metabolic process GO:0006595 14 10 0,000 0,02935734 0,06001945 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,02935734 0,05996614 ! B cell proliferation GO:0042100 14 10 0,000 0,02935734 0,05991293 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,02935734 0,05985982 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,02935734 0,0598068 ! lipid digestion GO:0044241 15 10 0,000 0,02935734 0,05975387 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,02935734 0,05970104 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,02935734 0,0596483 ! UV protection GO:0009650 14 10 0,000 0,02935734 0,05959565 ! entry into host cell GO:0030260 20 10 0,000 0,02935734 0,0595431 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,02935734 0,05949064 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,02935734 0,05943827 ! negative regulation of ossification GO:0030279 19 10 0,000 0,02935734 0,059386 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,02935734 0,05933381 ! regulation of bone resorption GO:0045124 24 10 0,000 0,02935734 0,05928172 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,02935734 0,05922972 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,02935734 0,05917781 ! regulation of organ growth GO:0046620 11 10 0,000 0,02935734 0,05912599 ! response to dsRNA GO:0043331 18 10 0,000 0,02935734 0,05907426 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,02935734 0,05902262 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,02935734 0,05897107 ! embryonic axis specification GO:0000578 12 10 0,000 0,02935734 0,05891961 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,02935734 0,05886824 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,02935734 0,05881697 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,02935734 0,05876578 ! cranial nerve development GO:0021545 12 10 0,000 0,02935734 0,05871468 ! fucose catabolic process GO:0019317 16 10 0,000 0,02935734 0,05866366 GO:0042355|L-fucose catabolic process, ! DNA methylation GO:0006306 15 10 0,000 0,02935734 0,05861274 GO:0006305|DNA alkylation, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,02935734 0,05856191 ! protein sumoylation GO:0016925 12 10 0,000 0,02935734 0,05851116 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,02935734 0,0584605 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,02935734 0,05840993 ! zymogen activation GO:0031638 14 10 0,000 0,02935734 0,05835944 ! salivary gland development GO:0007431 22 10 0,000 0,02935734 0,05830905 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,02935734 0,05825874 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,02935734 0,05820851 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,02935734 0,05815838 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,02935734 0,05810833 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,02935734 0,05805836 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,02935734 0,05800849 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,02935734 0,05795869 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,02935734 0,05790899 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,02935734 0,05785936 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,02935734 0,05780983 ! detection of bacterium GO:0016045 10 10 0,000 0,02935734 0,05776037 ! embryonic gut development GO:0048566 11 10 0,000 0,02935734 0,05771101 ! activation of innate immune response GO:0002218 10 10 0,000 0,02935734 0,05766172 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,02935734 0,05761252 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,02935734 0,05756341 ! developmental induction GO:0031128 13 10 0,000 0,02935734 0,05751438 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,02935734 0,05746543 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,02935734 0,05741656 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,02935734 0,05736778 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,02935734 0,05731908 ! response to virus GO:0009615 122 91 1,000 0,03002906 0,05858085 ! cell fate commitment GO:0045165 141 92 1,000 0,03063888 0,05971986 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,03125364 0,06086653 ! rRNA transcription GO:0009303 17 11 0,000 0,03224616 0,06274633 ! respiratory burst GO:0045730 14 11 0,000 0,03224616 0,06269329 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,03224616 0,06264034 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,03224616 0,06258747 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,03224616 0,0625347 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,03224616 0,06248202 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,03224616 0,06242943 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,03224616 0,06237692 ! RNA polyadenylation GO:0043631 19 11 0,000 0,03224616 0,0623245 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,03224616 0,06227217 GO:0050927|positive regulation of positive chemotaxis, ! detection of mechanical stimulus GO:0050982 15 11 0,000 0,03224616 0,06221993 ! mating GO:0007618 14 11 0,000 0,03224616 0,06216778 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,03224616 0,06211571 ! T cell proliferation GO:0042098 20 11 0,000 0,03224616 0,06206373 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,03224616 0,06201184 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,03224616 0,06196003 ! bone resorption GO:0045453 16 11 0,000 0,03224616 0,06190831 ! regulated secretory pathway GO:0045055 14 11 0,000 0,03224616 0,06185668 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,03224616 0,06180513 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,03224616 0,06175367 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,03224616 0,06170229 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,03224616 0,061651 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,03224616 0,0615998 ! syncytium formation GO:0006949 15 11 0,000 0,03224616 0,06154868 ! plasma membrane organization GO:0007009 18 11 0,000 0,03224616 0,06149764 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,03224616 0,06144669 ! focal adhesion formation GO:0048041 24 11 0,000 0,03224616 0,06139583 ! mitotic spindle organization GO:0007052 15 11 0,000 0,03224616 0,06134504 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,03224616 0,06129434 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,03224616 0,06124373 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,03224616 0,0611932 ! adult heart development GO:0007512 11 11 0,000 0,03224616 0,06114275 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,03224616 0,06109239 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,03224616 0,0610421 ! temperature homeostasis GO:0001659 16 11 0,000 0,03224616 0,06099191 ! L-glutamate transport GO:0015813 16 11 0,000 0,03224616 0,06094179 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,03224616 0,06089175 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,03224616 0,0608418 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,03224616 0,06079193 ! stem cell development GO:0048864 29 11 0,000 0,03224616 0,06074214 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,03224616 0,06069244 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,03224616 0,06064281 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,03224616 0,06059327 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,03224616 0,0605438 ! vasoconstriction GO:0042310 15 11 0,000 0,03224616 0,06049442 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,03224616 0,06044512 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,03224616 0,06039589 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,03224616 0,06034675 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,03224616 0,06029769 ! ribosome assembly GO:0042255 13 11 0,000 0,03224616 0,06024871 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,03224616 0,0601998 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,03224616 0,06015098 ! chromatin silencing GO:0006342 19 11 0,000 0,03224616 0,06010223 ! nucleosome positioning GO:0016584 13 11 0,000 0,03224616 0,06005357 ! T cell homeostasis GO:0043029 20 11 0,000 0,03224616 0,06000498 ! regulation of isotype switching GO:0045191 19 11 0,000 0,03224616 0,05995647 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,03224616 0,05990804 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,03224616 0,05985969 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,03224616 0,05981142 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,03224616 0,05976322 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,03224616 0,0597151 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,03224616 0,05966706 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,03224616 0,0596191 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,03224616 0,05957121 ! male genitalia development GO:0030539 13 11 0,000 0,03224616 0,0595234 ! cholesterol efflux GO:0033344 19 11 0,000 0,03224616 0,05947567 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,03224616 0,05942801 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,03224616 0,05938043 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,03224616 0,05933293 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,03224616 0,0592855 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,03224616 0,05923814 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,03224616 0,05919087 ! defense response to fungus GO:0050832 12 11 0,000 0,03224616 0,05914367 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,03224616 0,05909654 ! lysogeny GO:0030069 18 11 0,000 0,03224616 0,05904949 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,03224616 0,05900251 ! acrosome reaction GO:0007340 13 11 0,000 0,03224616 0,05895561 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,03224616 0,05890878 ! regulation of binding GO:0051098 151 95 1,000 0,03249781 0,05932139 ! in utero embryonic development GO:0001701 147 96 1,000 0,03312715 0,06042224 ! response to light stimulus GO:0009416 153 96 1,000 0,03312715 0,06037436 ! extracellular structure organization GO:0043062 156 99 1,000 0,03504382 0,06381693 ! protein import GO:0017038 156 99 1,000 0,03504382 0,06376644 ! lactation GO:0007595 20 12 0,000 0,03512654 0,06386644 ! reproductive cellular process GO:0048610 14 12 0,000 0,03512654 0,06381599 ! tRNA modification GO:0006400 14 12 0,000 0,03512654 0,06376562 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,03512654 0,06371533 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,03512654 0,06366512 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,03512654 0,06361499 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,03512654 0,06356494 ! non-recombinational repair GO:0000726 19 12 0,000 0,03512654 0,06351497 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,03512654 0,06346508 ! peroxisomal transport GO:0043574 21 12 0,000 0,03512654 0,06341526 ! cartilage condensation GO:0001502 18 12 0,000 0,03512654 0,06336552 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,03512654 0,06331586 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,03512654 0,06326628 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,03512654 0,06321678 ! heart looping GO:0001947 15 12 0,000 0,03512654 0,06316735 ! palate development GO:0060021 15 12 0,000 0,03512654 0,063118 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,03512654 0,06306873 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,03512654 0,06301953 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,03512654 0,06297041 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,03512654 0,06292137 ! arginine metabolic process GO:0006525 13 12 0,000 0,03512654 0,06287241 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,03512654 0,06282352 ! methionine metabolic process GO:0006555 13 12 0,000 0,03512654 0,0627747 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,03512654 0,06272596 ! Golgi organization GO:0007030 18 12 0,000 0,03512654 0,0626773 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,03512654 0,06262871 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,03512654 0,0625802 ! monoamine transport GO:0015844 13 12 0,000 0,03512654 0,06253177 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,03512654 0,0624834 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,03512654 0,06243512 ! L-amino acid transport GO:0015807 20 12 0,000 0,03512654 0,0623869 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,03512654 0,06233877 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,03512654 0,0622907 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,03512654 0,06224271 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,03512654 0,0621948 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,03512654 0,06214696 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,03512654 0,06209919 ! cerebellum development GO:0021549 13 12 0,000 0,03512654 0,06205149 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,03512654 0,06200387 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,03512654 0,06195632 ! histone methylation GO:0016571 15 12 0,000 0,03512654 0,06190884 ! autonomic nervous system development GO:0048483 23 12 0,000 0,03512654 0,06186144 ! gland morphogenesis GO:0022612 23 12 0,000 0,03512654 0,06181411 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,03512654 0,06176685 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,03512654 0,06171967 ! regulation of epidermis development GO:0045682 17 12 0,000 0,03512654 0,06167255 ! intestinal absorption GO:0050892 19 12 0,000 0,03512654 0,06162551 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,03512654 0,06157854 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,03512654 0,06153164 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,03512654 0,06148481 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,03512654 0,06143805 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,03512654 0,06139137 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,03512654 0,06134475 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,03512654 0,06129821 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,03512654 0,06125174 ! response to cold GO:0009409 14 12 0,000 0,03512654 0,06120533 ! protein localization in organelle GO:0033365 161 100 1,000 0,03569215 0,06214379 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,03799852 0,06610937 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,03799852 0,0660594 ! cGMP metabolic process GO:0046068 16 13 0,000 0,03799852 0,06600951 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,03799852 0,06595969 ! water transport GO:0006833 17 13 0,000 0,03799852 0,06590994 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,03799852 0,06586028 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,03799852 0,06581068 ! lipid localization GO:0010876 24 13 0,000 0,03799852 0,06576116 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,03799852 0,06571172 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,03799852 0,06566235 ! organelle fusion GO:0048284 28 13 0,000 0,03799852 0,06561305 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,03799852 0,06556383 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,03799852 0,06551468 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,03799852 0,06546561 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,03799852 0,06541661 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,03799852 0,06536768 ! response to hexose stimulus GO:0009746 19 13 0,000 0,03799852 0,06531882 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,03799852 0,06527004 ! glutamate metabolic process GO:0006536 18 13 0,000 0,03799852 0,06522133 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,03799852 0,0651727 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,03799852 0,06512413 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,03799852 0,06507564 ! NAD metabolic process GO:0019674 21 13 0,000 0,03799852 0,06502722 ! exocrine system development GO:0035272 27 13 0,000 0,03799852 0,06497887 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,03799852 0,0649306 ! bone mineralization GO:0030282 15 13 0,000 0,03799852 0,0648824 ! regulation of exocytosis GO:0017157 17 13 0,000 0,03799852 0,06483426 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,03799852 0,0647862 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,03799852 0,06473821 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,03799852 0,06469029 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,03799852 0,06464245 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,03799852 0,06459467 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,03799852 0,06454696 ! genitalia development GO:0048806 15 13 0,000 0,03799852 0,06449933 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,03799852 0,06445176 ! cellular pigmentation GO:0033059 24 13 0,000 0,03799852 0,06440426 ! tissue regeneration GO:0042246 21 13 0,000 0,03799852 0,06435684 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,03799852 0,06430948 ! cofactor transport GO:0051181 19 13 0,000 0,03799852 0,0642622 ! NADP metabolic process GO:0006739 18 13 0,000 0,03799852 0,06421498 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,03799852 0,06416783 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,03799852 0,06412075 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,03799852 0,06407374 ! gas transport GO:0015669 18 13 0,000 0,03799852 0,0640268 ! regulation of RNA stability GO:0043487 28 13 0,000 0,03799852 0,06397993 ! heme biosynthetic process GO:0006783 20 13 0,000 0,03799852 0,06393313 ! regulation of axon extension GO:0030516 23 13 0,000 0,03799852 0,06388639 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,03799852 0,06383973 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,03799852 0,06379313 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,03799852 0,0637466 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,03799852 0,06370014 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,03799852 0,06365374 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,03799852 0,06360741 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,04086211 0,06835116 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,04086211 0,06830149 ! superoxide anion generation GO:0042554 18 14 0,000 0,04086211 0,06825189 ! neuron maturation GO:0042551 21 14 0,000 0,04086211 0,06820236 ! regulation of S phase GO:0033261 18 14 0,000 0,04086211 0,0681529 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,04086211 0,06810351 ! myotube differentiation GO:0014902 21 14 0,000 0,04086211 0,0680542 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,04086211 0,06800495 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,04086211 0,06795578 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,04086211 0,06790668 ! inositol metabolic process GO:0006020 20 14 0,000 0,04086211 0,06785765 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,04086211 0,06780869 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,04086211 0,0677598 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,04086211 0,06771098 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,04086211 0,06766224 ! gene silencing by RNA GO:0031047 20 14 0,000 0,04086211 0,06761356 ! response to cAMP GO:0051591 19 14 0,000 0,04086211 0,06756495 ! startle response GO:0001964 21 14 0,000 0,04086211 0,06751641 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,04086211 0,06746794 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,04086211 0,06741955 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,04086211 0,06737122 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,04086211 0,06732296 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,04086211 0,06727476 ! glycine metabolic process GO:0006544 22 14 0,000 0,04086211 0,06722664 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,04086211 0,06717859 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,04086211 0,0671306 ! regulation of heart rate GO:0002027 23 14 0,000 0,04086211 0,06708269 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,04086211 0,06703484 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,04086211 0,06698706 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,04086211 0,06693935 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,04086211 0,06689171 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,04086211 0,06684413 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,04086211 0,06679662 ! axon cargo transport GO:0008088 27 14 0,000 0,04086211 0,06674918 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,04086211 0,06670181 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,04086211 0,0666545 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,04086211 0,06660726 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,04086211 0,06656009 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,04086211 0,06651298 ! mRNA splice site selection GO:0006376 26 14 0,000 0,04086211 0,06646595 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,04086211 0,06641897 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,04086211 0,06637207 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,04086211 0,06632523 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,04086211 0,06627845 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,04086211 0,06623175 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,04086211 0,0661851 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,04086211 0,06613853 ! muscle maintenance GO:0046716 19 14 0,000 0,04086211 0,06609202 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,04086211 0,06604557 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,04086211 0,06599919 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,04086211 0,06595287 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,04086211 0,06590662 ! cell killing GO:0001906 20 14 0,000 0,04086211 0,06586044 ! cilium assembly GO:0042384 20 14 0,000 0,04086211 0,06581432 ! peptide hormone secretion GO:0030072 23 14 0,000 0,04086211 0,06576826 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,04371734 0,0703146 ! positive regulation of cell size GO:0045793 20 15 0,000 0,04371734 0,07026546 ! metencephalon development GO:0022037 19 15 0,000 0,04371734 0,07021639 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,04371734 0,0701674 ! skin development GO:0043588 25 15 0,000 0,04371734 0,07011846 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,04371734 0,0700696 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,04371734 0,07002081 ! lipid phosphorylation GO:0046834 23 15 0,000 0,04371734 0,06997208 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,04371734 0,06992342 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,04371734 0,06987483 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,04371734 0,0698263 ! bile acid metabolic process GO:0008206 22 15 0,000 0,04371734 0,06977785 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,04371734 0,06972946 ! adult walking behavior GO:0007628 25 15 0,000 0,04371734 0,06968113 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,04371734 0,06963288 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,04371734 0,06958469 ! myoblast differentiation GO:0045445 27 15 0,000 0,04371734 0,06953657 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,04371734 0,06948851 ! regulation of survival gene product expression GO:0045884 20 15 0,000 0,04371734 0,06944052 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,04371734 0,0693926 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,04371734 0,06934474 ! response to osmotic stress GO:0006970 22 15 0,000 0,04371734 0,06929695 ! vesicle coating GO:0006901 25 15 0,000 0,04371734 0,06924923 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,04371734 0,06920157 ! DNA integration GO:0015074 22 15 0,000 0,04371734 0,06915397 ! peptide secretion GO:0002790 27 15 0,000 0,04371734 0,06910644 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,04371734 0,06905898 ! regulation of vasodilation GO:0042312 24 15 0,000 0,04371734 0,06901158 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,04371734 0,06896425 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 0,000 0,04371734 0,06891698 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,04371734 0,06886978 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,04371734 0,06882264 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,04371734 0,06877557 ! biomineral formation GO:0031214 18 15 0,000 0,04371734 0,06872856 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,04371734 0,06868161 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,04371734 0,06863473 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,04371734 0,06858791 ! dopamine metabolic process GO:0042417 30 15 0,000 0,04371734 0,06854116 ! organic cation transport GO:0015695 19 15 0,000 0,04371734 0,06849447 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,04371734 0,06844784 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,04371734 0,06840128 ! defense response to virus GO:0051607 27 15 0,000 0,04371734 0,06835478 ! peptide hormone processing GO:0016486 19 15 0,000 0,04371734 0,06830834 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,04371734 0,06826197 ! protein secretion GO:0009306 27 16 0,000 0,04656423 0,07265789 ! hormone secretion GO:0046879 25 16 0,000 0,04656423 0,07260863 ! bone remodeling GO:0046849 24 16 0,000 0,04656423 0,07255944 ! endothelial cell migration GO:0043542 22 16 0,000 0,04656423 0,07251031 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,04656423 0,07246125 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,04656423 0,07241226 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,04656423 0,07236333 ! patterning of blood vessels GO:0001569 24 16 0,000 0,04656423 0,07231447 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,04656423 0,07226568 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,04656423 0,07221695 ! protein polyubiquitination GO:0000209 26 16 0,000 0,04656423 0,07216828 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,04656423 0,07211969 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,04656423 0,07207115 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,04656423 0,07202269 ! regulation of protein binding GO:0043393 27 16 0,000 0,04656423 0,07197428 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,04656423 0,07192595 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,04656423 0,07187767 ! protein export from nucleus GO:0006611 24 16 0,000 0,04656423 0,07182947 ! negative regulation of immune response GO:0050777 28 16 0,000 0,04656423 0,07178132 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,04656423 0,07173324 ! DNA replication initiation GO:0006270 25 16 0,000 0,04656423 0,07168523 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,04656423 0,07163728 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,04656423 0,07158939 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,04656423 0,07154157 ! oogenesis GO:0048477 23 16 0,000 0,04656423 0,07149381 ! neural crest cell migration GO:0001755 24 16 0,000 0,04656423 0,07144612 ! G1 phase GO:0051318 27 16 0,000 0,04656423 0,07139849 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,04656423 0,07135092 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,04656423 0,07130342 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,04656423 0,07125598 ! steroid catabolic process GO:0006706 22 16 0,000 0,04656423 0,0712086 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,04656423 0,07116128 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,04656423 0,07111403 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,04656423 0,07106684 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,04656423 0,07101972 ! sperm-egg recognition GO:0035036 16 16 0,000 0,04656423 0,07097265 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,04656423 0,07092565 ! nerve development GO:0021675 18 16 0,000 0,04656423 0,07087871 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,04656423 0,07083183 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,04656423 0,07078502 ! negative regulation of translation GO:0017148 22 16 0,000 0,04656423 0,07073827 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,04940281 0,07500097 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,04940281 0,0749515 ! negative regulation of defense response GO:0031348 19 17 0,000 0,04940281 0,07490209 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,04940281 0,07485275 ! glycerol metabolic process GO:0006071 20 17 0,000 0,04940281 0,07480347 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,04940281 0,07475426 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,04940281 0,07470511 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,04940281 0,07465603 ! signal complex assembly GO:0007172 29 17 0,000 0,04940281 0,07460701 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,04940281 0,07455805 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,04940281 0,07450916 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,04940281 0,07446033 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,04940281 0,07441157 ! memory GO:0007613 25 17 0,000 0,04940281 0,07436287 ! keratinization GO:0031424 17 17 0,000 0,04940281 0,07431424 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,04940281 0,07426567 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,04940281 0,07421716 ! retinoid metabolic process GO:0001523 22 17 0,000 0,04940281 0,07416871 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,04940281 0,07412033 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,04940281 0,07407201 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,04940281 0,07402376 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,04940281 0,07397557 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,04940281 0,07392744 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,04940281 0,07387937 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,04940281 0,07383136 ! membrane budding GO:0006900 29 17 0,000 0,04940281 0,07378342 ! heme metabolic process GO:0042168 27 17 0,000 0,04940281 0,07373554 ! actin filament bundle formation GO:0051017 26 17 0,000 0,04940281 0,07368772 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,04940281 0,07363997 ! body fluid secretion GO:0007589 27 17 0,000 0,04940281 0,07359227 ! stem cell differentiation GO:0048863 36 17 0,000 0,04940281 0,07354464 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,04940281 0,07349707 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,04940281 0,07344956 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,04940281 0,07340211 ! sensory perception of pain GO:0019233 23 17 0,000 0,04940281 0,07335473 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,04940281 0,0733074 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,04940281 0,07326014 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,04940281 0,07321293 ! synaptogenesis GO:0007416 24 17 0,000 0,04940281 0,07316579 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,04940281 0,07311871 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,04940281 0,07307169 ! cell-cell junction organization GO:0045216 25 17 0,000 0,04940281 0,07302472 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,04940281 0,07297782 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,04940281 0,07293098 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,04940281 0,0728842 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,04940281 0,07283748 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,04940281 0,07279082 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,04940281 0,07274422 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,05223311 0,07686254 ! positive regulation of translation GO:0045727 28 18 0,000 0,05223311 0,07681339 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,05223311 0,07676431 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,05223311 0,07671529 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,05223311 0,07666633 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,05223311 0,07661744 ! cAMP metabolic process GO:0046058 33 18 0,000 0,05223311 0,07656861 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,05223311 0,07651984 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,05223311 0,07647113 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,05223311 0,07642248 ! axis specification GO:0009798 26 18 0,000 0,05223311 0,0763739 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,05223311 0,07632538 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,05223311 0,07627692 ! pancreas development GO:0031016 26 18 0,000 0,05223311 0,07622852 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,05223311 0,07618018 ! glutamine metabolic process GO:0006541 23 18 0,000 0,05223311 0,0761319 ! response to retinoic acid GO:0032526 25 18 0,000 0,05223311 0,07608369 ! pigmentation during development GO:0048066 31 18 0,000 0,05223311 0,07603553 ! central nervous system neuron development GO:0021954 30 18 0,000 0,05223311 0,07598744 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,05223311 0,07593941 ! fucose metabolic process GO:0006004 26 18 0,000 0,05223311 0,07589144 ! response to fungus GO:0009620 19 18 0,000 0,05223311 0,07584352 ! peptide cross-linking GO:0018149 31 18 0,000 0,05223311 0,07579567 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,05223311 0,07574788 ! heart process GO:0003015 27 18 0,000 0,05223311 0,07570015 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,05223311 0,07565248 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,05223311 0,07560487 ! visual learning GO:0008542 35 18 0,000 0,05223311 0,07555732 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,05223311 0,07550983 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,05223311 0,0754624 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,05223311 0,07541503 ! vitamin transport GO:0051180 24 18 0,000 0,05223311 0,07536772 ! hormone transport GO:0009914 27 18 0,000 0,05223311 0,07532047 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,05223311 0,07527327 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,05223311 0,07522614 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,05223311 0,07517906 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,05223311 0,07513205 ! cell-cell recognition GO:0009988 20 18 0,000 0,05223311 0,07508509 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,05223311 0,07503819 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,05223311 0,07499135 ! regulation of glucose import GO:0046324 21 18 0,000 0,05223311 0,07494457 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,05223311 0,07489784 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,05505513 0,07889521 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,05505513 0,07884608 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,05505513 0,07879702 ! positive regulation of ossification GO:0045778 30 19 0,000 0,05505513 0,07874801 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,05505513 0,07869907 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,05505513 0,07865019 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,05505513 0,07860137 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,05505513 0,07855261 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,05505513 0,07850391 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,05505513 0,07845527 ! regeneration GO:0031099 32 19 0,000 0,05505513 0,07840669 ! response to alkaloid GO:0043279 32 19 0,000 0,05505513 0,07835817 ! sensory perception of taste GO:0050909 23 19 0,000 0,05505513 0,07830971 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,05505513 0,07826131 ! smooth muscle contraction GO:0006939 36 19 0,000 0,05505513 0,07821297 ! peroxisome organization GO:0007031 29 19 0,000 0,05505513 0,07816469 ! digestive system process GO:0022600 30 19 0,000 0,05505513 0,07811647 ! cellular response to reactive oxygen species GO:0034614 27 19 0,000 0,05505513 0,07806831 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,05505513 0,07802021 ! response to vitamin A GO:0033189 26 19 0,000 0,05505513 0,07797217 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,05505513 0,07792419 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,05505513 0,07787626 ! cell structure disassembly during apoptosis GO:0006921 24 19 0,000 0,05505513 0,0778284 ! apoptotic nuclear changes GO:0030262 24 19 0,000 0,05505513 0,07778059 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,05505513 0,07773284 ! plasma membrane fusion GO:0045026 23 19 0,000 0,05505513 0,07768516 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,05505513 0,07763753 ! cytolysis GO:0019835 20 19 0,000 0,05505513 0,07758995 ! renal system process GO:0003014 35 19 0,000 0,05505513 0,07754244 ! vasodilation GO:0042311 33 19 0,000 0,05505513 0,07749498 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,05505513 0,07744759 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,05505513 0,07740025 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,05505513 0,07735297 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,05505513 0,07730574 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,05505513 0,07725857 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,05505513 0,07721147 ! sarcomere organization GO:0045214 23 19 0,000 0,05505513 0,07716441 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,05505513 0,07711742 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,05505513 0,07707048 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,05505513 0,0770236 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,05505513 0,07697678 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,05505513 0,07693001 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,05505513 0,07688331 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,05505513 0,07683665 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,05505513 0,07679006 ! protein stabilization GO:0050821 26 19 0,000 0,05505513 0,07674352 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,05786892 0,08061691 ! iron ion transport GO:0006826 37 20 0,000 0,05786892 0,08056811 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,05786892 0,08051937 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,05786892 0,08047068 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,05786892 0,08042206 ! response to vitamin GO:0033273 29 20 0,000 0,05786892 0,0803735 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,05786892 0,08032499 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,05786892 0,08027654 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,05786892 0,08022816 ! spinal cord development GO:0021510 31 20 0,000 0,05786892 0,08017983 ! response to ethanol GO:0045471 37 20 0,000 0,05786892 0,08013155 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,05786892 0,08008334 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,05786892 0,08003518 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,05786892 0,07998709 ! chromosome condensation GO:0030261 31 20 0,000 0,05786892 0,07993905 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,05786892 0,07989106 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,05786892 0,07984314 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,05786892 0,07979527 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,05786892 0,07974746 ! DNA modification GO:0006304 28 20 0,000 0,05786892 0,07969971 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,05786892 0,07965201 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,05786892 0,07960437 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,05786892 0,07955679 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,05786892 0,07950927 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,05786892 0,0794618 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,05786892 0,07941439 ! collagen catabolic process GO:0030574 25 20 0,000 0,05786892 0,07936703 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,05786892 0,07931973 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,05786892 0,07927249 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,05786892 0,0792253 ! alditol metabolic process GO:0019400 24 20 0,000 0,05786892 0,07917817 ! actin filament-based movement GO:0030048 34 20 0,000 0,05786892 0,0791311 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,06067448 0,08291819 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,06067448 0,08286895 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,06067448 0,08281977 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,06067448 0,08277065 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,06067448 0,08272159 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,06067448 0,08267258 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 0,000 0,06067448 0,08262363 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,06067448 0,08257474 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,06067448 0,08252591 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,06067448 0,08247714 ! vesicle docking GO:0048278 27 21 0,000 0,06067448 0,08242842 ! phototransduction GO:0007602 25 21 0,000 0,06067448 0,08237976 ! dendrite development GO:0016358 35 21 0,000 0,06067448 0,08233116 ! visual behavior GO:0007632 39 21 0,000 0,06067448 0,08228262 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,06067448 0,08223413 ! ovarian follicle development GO:0001541 30 21 0,000 0,06067448 0,0821857 ! activation of pro-apoptotic gene products GO:0008633 36 21 0,000 0,06067448 0,08213733 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,06067448 0,08208901 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,06067448 0,08204075 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,06067448 0,08199255 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,06067448 0,0819444 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,06067448 0,08189631 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,06067448 0,08184828 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,06067448 0,0818003 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,06067448 0,08175238 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,06067448 0,08170452 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,06067448 0,08165671 ! fatty acid transport GO:0015908 30 21 0,000 0,06067448 0,08160896 ! immunoglobulin production GO:0002377 33 21 0,000 0,06067448 0,08156126 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,06067448 0,08151362 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,06067448 0,08146603 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,06067448 0,0814185 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,06067448 0,08137103 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,06067448 0,08132361 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,06067448 0,08127625 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,06067448 0,08122894 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,06067448 0,08118168 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,06067448 0,08113449 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,06067448 0,08108734 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,06067448 0,08104025 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,06067448 0,08099322 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,06067448 0,08094624 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,06067448 0,08089931 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,06347186 0,08458011 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,06347186 0,08453114 ! viral genome replication GO:0019079 29 22 0,000 0,06347186 0,08448222 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,06347186 0,08443336 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,06347186 0,08438455 ! leukocyte adhesion GO:0007159 38 22 0,000 0,06347186 0,0843358 ! molting cycle process GO:0022404 40 22 0,000 0,06347186 0,08428711 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,06347186 0,08423847 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,06347186 0,08418989 ! vasculogenesis GO:0001570 33 22 0,000 0,06347186 0,08414137 ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,06347186 0,0840929 GO:0010810|regulation of cell-substrate adhesion, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,06347186 0,08404449 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,06347186 0,08399613 ! lysosome organization GO:0007040 37 22 0,000 0,06347186 0,08394783 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,06347186 0,08389958 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,06347186 0,08385139 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,06347186 0,08380326 ! regulation of behavior GO:0050795 38 22 0,000 0,06347186 0,08375518 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,06347186 0,08370715 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,06347186 0,08365918 ! membrane depolarization GO:0051899 35 22 0,000 0,06347186 0,08361127 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,06347186 0,08356341 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,06347186 0,0835156 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,06347186 0,08346785 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,06347186 0,08342016 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,06347186 0,08337251 ! blastocyst development GO:0001824 37 22 0,000 0,06347186 0,08332493 ! neural tube closure GO:0001843 33 22 0,000 0,06347186 0,08327739 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,06347186 0,08322992 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,06626106 0,08683786 ! neuron fate commitment GO:0048663 32 23 0,000 0,06626106 0,0867884 ! embryonic pattern specification GO:0009880 31 23 0,000 0,06626106 0,08673901 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,06626106 0,08668967 ! cellular iron ion homeostasis GO:0006879 37 23 0,000 0,06626106 0,08664038 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,06626106 0,08659116 ! vesicle targeting GO:0006903 32 23 0,000 0,06626106 0,08654199 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,06626106 0,08649287 ! osteoblast differentiation GO:0001649 40 23 0,000 0,06626106 0,08644381 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,06626106 0,08639481 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,06626106 0,08634586 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,06626106 0,08629696 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,06626106 0,08624813 ! cellular response to oxidative stress GO:0034599 33 23 0,000 0,06626106 0,08619934 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,06626106 0,08615061 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,06626106 0,08610194 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,06626106 0,08605332 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,06626106 0,08600476 ! cell fate determination GO:0001709 45 23 0,000 0,06626106 0,08595625 ! pentose metabolic process GO:0019321 31 23 0,000 0,06626106 0,0859078 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,06626106 0,0858594 ! spermatid development GO:0007286 33 23 0,000 0,06626106 0,08581106 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,06626106 0,08576277 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,06626106 0,08571453 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,06626106 0,08566635 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,06626106 0,08561822 ! telomere organization GO:0032200 32 23 0,000 0,06626106 0,08557015 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,06626106 0,08552213 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,06626106 0,08547417 ! regulation of amine transport GO:0051952 38 23 0,000 0,06626106 0,08542625 ! liver development GO:0001889 40 23 0,000 0,06626106 0,0853784 ! initiation of viral infection GO:0019059 42 24 0,000 0,06904211 0,08891202 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,06904211 0,08886226 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,06904211 0,08881256 ! superoxide metabolic process GO:0006801 32 24 0,000 0,06904211 0,08876292 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,06904211 0,08871333 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,06904211 0,0886638 ! fat cell differentiation GO:0045444 37 24 0,000 0,06904211 0,08861432 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,06904211 0,0885649 ! sperm motility GO:0030317 27 24 0,000 0,06904211 0,08851553 ! vacuole organization GO:0007033 39 24 0,000 0,06904211 0,08846622 ! receptor metabolic process GO:0043112 37 24 0,000 0,06904211 0,08841696 ! neural crest cell development GO:0014032 39 24 0,000 0,06904211 0,08836776 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,06904211 0,08831861 ! primary neural tube formation GO:0014020 35 24 0,000 0,06904211 0,08826952 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,06904211 0,08822048 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,06904211 0,08817149 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,06904211 0,08812256 ! glutathione metabolic process GO:0006749 29 24 0,000 0,06904211 0,08807369 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,06904211 0,08802487 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,06904211 0,0879761 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,06904211 0,08792739 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,07181504 0,09140819 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,07181504 0,09135763 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,07181504 0,09130713 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,07181504 0,09125669 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,07181504 0,0912063 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 0,000 0,07181504 0,09115596 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,07181504 0,09110568 ! peptide transport GO:0015833 43 25 0,000 0,07181504 0,09105546 ! male gonad development GO:0008584 33 25 0,000 0,07181504 0,09100529 ! iron ion homeostasis GO:0055072 39 25 0,000 0,07181504 0,09095518 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,07181504 0,09090512 ! phospholipid transport GO:0015914 35 25 0,000 0,07181504 0,09085512 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,07181504 0,09080517 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,07181504 0,09075527 ! detection of light stimulus GO:0009583 30 25 0,000 0,07181504 0,09070544 ! leukocyte proliferation GO:0070661 39 25 0,000 0,07181504 0,09065565 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,07457987 0,09409419 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,07457987 0,0940426 ! translational initiation GO:0006413 43 26 0,000 0,07457987 0,09399107 ! circadian rhythm GO:0007623 42 26 0,000 0,07457987 0,0939396 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,07457987 0,09388818 ! post-embryonic development GO:0009791 42 26 0,000 0,07457987 0,09383682 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,07457987 0,09378551 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,07457987 0,09373427 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,07457987 0,09368307 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,07457987 0,09363194 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,07457987 0,09358085 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,07457987 0,09352983 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,07457987 0,09347886 ! regulation of coagulation GO:0050818 39 26 0,000 0,07457987 0,09342794 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,07733662 0,09682865 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,07733662 0,09677597 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,07733662 0,09672335 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,07733662 0,09667078 ! membrane docking GO:0022406 39 27 0,000 0,07733662 0,09661827 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,07733662 0,09656582 ! catechol metabolic process GO:0009712 43 27 0,000 0,07733662 0,09651342 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,07733662 0,09646108 ! acute-phase response GO:0006953 42 27 0,000 0,07733662 0,0964088 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,07733662 0,09635657 ! myofibril assembly GO:0030239 36 27 0,000 0,07733662 0,0963044 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,07733662 0,09625229 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,07733662 0,09620023 ! natural killer cell activation GO:0030101 35 27 0,000 0,07733662 0,09614823 ! lipid oxidation GO:0034440 38 27 0,000 0,07733662 0,09609629 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,07733662 0,0960444 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,07733662 0,09599257 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,07733662 0,0959408 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,07733662 0,09588908 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,07733662 0,09583741 ! gene silencing GO:0016458 41 27 0,000 0,07733662 0,0957858 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,08008532 0,09913683 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,08008532 0,09908351 ! phenol metabolic process GO:0018958 44 28 0,000 0,08008532 0,09903023 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,08008532 0,09897702 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,08008532 0,09892386 ! cell junction assembly GO:0034329 56 28 0,000 0,08008532 0,09887077 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,08008532 0,09881772 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,08008532 0,09876474 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,08008532 0,09871181 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,08008532 0,09865894 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,08008532 0,09860612 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,08008532 0,09855336 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,08008532 0,09850066 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,08008532 0,09844801 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,08008532 0,09839543 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,08008532 0,09834289 ! mesoderm formation GO:0001707 46 28 0,000 0,08008532 0,09829041 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,08008532 0,09823799 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,08008532 0,09818563 ! BMP signaling pathway GO:0030509 40 28 0,000 0,08008532 0,09813332 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,08008532 0,09808106 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,08008532 0,09802886 ! neural tube formation GO:0001841 41 28 0,000 0,08008532 0,09797672 ! placenta development GO:0001890 37 28 0,000 0,08008532 0,09792463 ! regulation of B cell activation GO:0050864 42 28 0,000 0,08008532 0,0978726 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,08282598 0,10116822 ! regulation of innate immune response GO:0045088 38 29 0,000 0,08282598 0,10111452 ! ovulation cycle process GO:0022602 41 29 0,000 0,08282598 0,10106088 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,08282598 0,1010073 ! protein targeting to membrane GO:0006612 53 29 0,000 0,08282598 0,10095377 ! mismatch repair GO:0006298 34 29 0,000 0,08282598 0,1009003 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,08282598 0,10084688 ! muscle cell development GO:0055001 38 29 0,000 0,08282598 0,10079353 ! formation of primary germ layer GO:0001704 48 29 0,000 0,08282598 0,10074022 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,08282598 0,10068698 ! eye morphogenesis GO:0048592 51 29 0,000 0,08282598 0,10063379 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,08282598 0,10058066 ! tissue homeostasis GO:0001894 42 29 0,000 0,08282598 0,10052758 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,08555864 0,10378949 ! collagen metabolic process GO:0032963 40 30 0,000 0,08555864 0,10373478 ! organic anion transport GO:0015711 51 30 0,000 0,08555864 0,10368012 ! cholesterol transport GO:0030301 46 30 0,000 0,08555864 0,10362553 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,08555864 0,10357099 ! spliceosome assembly GO:0000245 49 30 0,000 0,08555864 0,1035165 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,08555864 0,10346208 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,08555864 0,10340771 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,08555864 0,1033534 ! ceramide metabolic process GO:0006672 43 30 0,000 0,08555864 0,10329915 ! ovulation cycle GO:0042698 43 30 0,000 0,08555864 0,10324495 ! hindbrain development GO:0030902 45 30 0,000 0,08555864 0,10319081 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,08555864 0,10313673 ! adult locomotory behavior GO:0008344 47 30 0,000 0,08555864 0,1030827 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,08555864 0,10302873 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,08555864 0,10297482 ! response to heat GO:0009408 41 30 0,000 0,08555864 0,10292096 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,08555864 0,10286716 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,08555864 0,10281341 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,08828331 0,10603218 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,08828331 0,10597684 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,08828331 0,10592155 ! odontogenesis GO:0042476 50 31 0,000 0,08828331 0,10586633 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,08828331 0,10581116 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,08828331 0,10575605 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,08828331 0,105701 ! metanephros development GO:0001656 58 31 0,000 0,08828331 0,105646 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,08828331 0,10559106 ! response to mechanical stimulus GO:0009612 43 31 0,000 0,08828331 0,10553618 ! cell fate specification GO:0001708 37 31 0,000 0,08828331 0,10548136 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,08828331 0,10542659 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,08828331 0,10537188 ! RNA modification GO:0009451 40 31 0,000 0,08828331 0,10531723 ! regulation of muscle development GO:0048634 48 32 0,000 0,09100002 0,10850184 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,09100002 0,10844562 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,09100002 0,10838946 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,09100002 0,10833336 ! regulation of protein stability GO:0031647 48 32 0,000 0,09100002 0,10827731 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,09100002 0,10822133 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,09100002 0,1081654 ! cytokine production GO:0001816 44 32 0,000 0,09100002 0,10810953 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,09100002 0,10805371 ! vesicle localization GO:0051648 47 32 0,000 0,09100002 0,10799796 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,09370879 0,11115534 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,09370879 0,11109805 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,09370879 0,11104081 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,09370879 0,11098363 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,09370879 0,11092651 ! ear morphogenesis GO:0042471 42 33 0,000 0,09370879 0,11086945 ! actomyosin structure organization GO:0031032 43 33 0,000 0,09370879 0,11081245 ! cell junction organization GO:0034330 63 33 0,000 0,09370879 0,1107555 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,09370879 0,11069862 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,09370879 0,11064179 ! nucleus organization GO:0006997 49 33 0,000 0,09370879 0,11058502 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,09370879 0,11052831 ! female gonad development GO:0008585 49 33 0,000 0,09370879 0,11047166 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,09370879 0,11041507 ! positive regulation of cell development GO:0010720 54 33 0,000 0,09370879 0,11035853 ! lipid homeostasis GO:0055088 55 33 0,000 0,09370879 0,11030205 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,09370879 0,11024563 ! regulation of proteolysis GO:0030162 50 33 0,000 0,09370879 0,11018927 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,09370879 0,11013296 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,09370879 0,11007672 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,09640964 0,11319151 ! mRNA catabolic process GO:0006402 48 34 0,000 0,09640964 0,11313376 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,09640964 0,11307607 ! feeding behavior GO:0007631 45 34 0,000 0,09640964 0,11301843 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,09640964 0,11296086 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,09640964 0,11290334 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,09640964 0,11284589 ! female gamete generation GO:0007292 43 34 0,000 0,09640964 0,11278849 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,09640964 0,11273115 ! polyol metabolic process GO:0019751 44 34 0,000 0,09640964 0,11267387 ! aerobic respiration GO:0009060 47 34 0,000 0,09640964 0,11261664 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,09640964 0,11255948 ! embryonic organ development GO:0048568 45 34 0,000 0,09640964 0,11250237 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,09910259 0,11558619 ! Notch signaling pathway GO:0007219 56 35 0,000 0,09910259 0,11552761 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,09910259 0,11546908 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,09910259 0,11541062 ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,09910259 0,11535221 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,09910259 0,11529386 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,09910259 0,11523557 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,09910259 0,11517735 ! pigment metabolic process GO:0042440 61 35 0,000 0,09910259 0,11511917 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,09910259 0,11506106 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,09910259 0,11500301 ! response to reactive oxygen species GO:0000302 55 36 0,000 0,10178768 0,11805933 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,10178768 0,11799983 ! negative regulation of binding GO:0051100 58 36 0,000 0,10178768 0,11794038 ! tissue remodeling GO:0048771 62 36 0,000 0,10178768 0,117881 ! neural tube development GO:0021915 50 36 0,000 0,10178768 0,11782167 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,10178768 0,1177624 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,10178768 0,1177032 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,10178768 0,11764405 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,10446491 0,1206777 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,10446491 0,12061712 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,10446491 0,1205566 ! ion transmembrane transport GO:0034220 56 37 0,000 0,10446491 0,12049614 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,10446491 0,12043574 ! amino acid activation GO:0043038 52 37 0,000 0,10446491 0,1203754 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,10446491 0,12031512 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,10713432 0,1233278 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,10713432 0,1232661 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,10713432 0,12320447 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,10713432 0,1231429 ! phagocytosis GO:0006909 60 38 0,000 0,10713432 0,12308139 ! pigmentation GO:0043473 74 38 0,000 0,10713432 0,12301994 ! maintenance of location in cell GO:0051651 69 38 0,000 0,10713432 0,12295855 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,10979593 0,12595044 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,10979593 0,12588765 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,10979593 0,12582493 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,10979593 0,12576226 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,10979593 0,12569967 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,10979593 0,12563713 ! male sex differentiation GO:0046661 53 39 0,000 0,10979593 0,12557465 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,10979593 0,12551224 ! chromatin remodeling GO:0006338 68 39 0,000 0,10979593 0,12544989 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,10979593 0,1253876 ! JNK cascade GO:0007254 54 39 0,000 0,10979593 0,12532537 ! developmental growth GO:0048589 62 39 0,000 0,10979593 0,12526321 ! cell growth GO:0016049 61 39 0,000 0,10979593 0,1252011 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,11244975 0,12816374 ! response to calcium ion GO:0051592 58 40 0,000 0,11244975 0,12810026 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,11244975 0,12803684 ! regulation of tube size GO:0035150 60 40 0,000 0,11244975 0,12797349 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,11244975 0,1279102 ! detection of stimulus involved in sensory perception GO:0050906 50 40 0,000 0,11244975 0,12784697 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,11244975 0,1277838 ! peptide metabolic process GO:0006518 56 40 0,000 0,11244975 0,1277207 ! inner ear development GO:0048839 57 40 0,000 0,11244975 0,12765766 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,11244975 0,12759468 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! epidermal cell differentiation GO:0009913 53 40 0,000 0,11244975 0,12753176 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,11244975 0,12746891 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,11509581 0,13040412 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,11509581 0,13033991 ! glucose transport GO:0015758 52 41 0,000 0,11509581 0,13027577 ! endosome transport GO:0016197 71 41 0,000 0,11509581 0,13021169 ! striated muscle contraction GO:0006941 62 41 0,000 0,11509581 0,13014767 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,11509581 0,13008371 ! biopolymer methylation GO:0043414 62 41 0,000 0,11509581 0,13001982 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,11509581 0,12995599 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,11773413 0,13286973 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,11773413 0,13280456 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,11773413 0,13273946 ! hexose transport GO:0008645 54 42 0,000 0,11773413 0,13267443 GO:0015749|monosaccharide transport, ! embryonic skeletal system development GO:0048706 56 42 0,000 0,11773413 0,13260945 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,11773413 0,13254455 ! excretion GO:0007588 63 42 0,000 0,11773413 0,1324797 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,11773413 0,13241492 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,11773413 0,1323502 ! regulation of gene expression, epigenetic GO:0040029 72 42 0,000 0,11773413 0,13228554 ! regulation of cell shape GO:0008360 78 42 0,000 0,11773413 0,13222095 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 0,000 0,12036474 0,13510928 ! leukocyte migration GO:0050900 60 43 0,000 0,12036474 0,13504337 ! neuromuscular process GO:0050905 79 43 0,000 0,12036474 0,13497753 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,12036474 0,13491175 ! tRNA processing GO:0008033 49 43 0,000 0,12036474 0,13484603 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,12036474 0,13478038 ! vesicle organization GO:0016050 79 43 0,000 0,12036474 0,1347148 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,12036474 0,13464927 ! methylation GO:0032259 64 43 0,000 0,12036474 0,13458382 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,12298766 0,13744976 ! regulation of ion transport GO:0043269 57 44 0,000 0,12298766 0,13738301 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,12298766 0,13731632 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,12298766 0,13724969 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,12298766 0,13718313 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,12298766 0,13711663 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,12298766 0,1370502 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,12298766 0,13698383 ! detection of abiotic stimulus GO:0009582 58 44 0,000 0,12298766 0,13691753 ! RNA catabolic process GO:0006401 64 45 0,000 0,1256029 0,13976133 ! positive regulation of defense response GO:0031349 59 45 0,000 0,1256029 0,13969375 ! regulation of translational initiation GO:0006446 64 45 0,000 0,1256029 0,13962623 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,1256029 0,13955878 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,1256029 0,13949139 ! cell maturation GO:0048469 60 45 0,000 0,1256029 0,13942407 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,1282105 0,14224995 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,1282105 0,14218136 ! cell redox homeostasis GO:0045454 63 46 0,000 0,1282105 0,14211284 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,1282105 0,14204439 ! regulation of ossification GO:0030278 71 46 0,000 0,1282105 0,141976 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,1282105 0,14190767 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,13081047 0,14471577 ! viral infectious cycle GO:0019058 71 47 0,000 0,13081047 0,14464619 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,13081047 0,14457668 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,13081047 0,14450724 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,13081047 0,14443787 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,13081047 0,14436856 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,13081047 0,14429932 ! chloride transport GO:0006821 67 48 0,000 0,13340283 0,14708845 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,13340283 0,14701797 ! response to temperature stimulus GO:0009266 62 48 0,000 0,13340283 0,14694756 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,13340283 0,14687722 ! gastrulation GO:0007369 73 48 0,000 0,13340283 0,14680694 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,13340283 0,14673673 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,13340283 0,14666659 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,13340283 0,14659652 ! regulation of endocytosis GO:0030100 63 48 0,000 0,13340283 0,14652651 ! nuclear export GO:0051168 69 48 0,000 0,13340283 0,14645657 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,13340283 0,14638669 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,13598761 0,14915189 ! sensory perception of smell GO:0007608 61 49 0,000 0,13598761 0,14908079 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,13598761 0,14900977 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,13598761 0,14893881 ! RNA elongation GO:0006354 62 49 0,000 0,13598761 0,14886792 ! germ cell development GO:0007281 68 49 0,000 0,13598761 0,1487971 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,13598761 0,14872635 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,13598761 0,14865566 ! cartilage development GO:0051216 70 49 0,000 0,13598761 0,14858504 ! maintenance of location GO:0051235 84 49 0,000 0,13598761 0,14851449 ! regulation of actin filament length GO:0030832 72 50 0,000 0,13856483 0,15125729 ! ear development GO:0043583 72 50 0,000 0,13856483 0,15118554 ! membrane fusion GO:0006944 80 50 0,000 0,13856483 0,15111385 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,13856483 0,15104223 ! lipid modification GO:0030258 73 50 0,000 0,13856483 0,15097068 ! proton transport GO:0015992 75 50 0,000 0,13856483 0,1508992 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,13856483 0,15082778 ! hydrogen transport GO:0006818 77 51 0,000 0,14113451 0,15355221 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,14113451 0,15347961 GO:0010863|positive regulation of phospholipase C activity, ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,14113451 0,15340707 ! adult behavior GO:0030534 80 51 0,000 0,14113451 0,15333461 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,14113451 0,15326221 ! transition metal ion transport GO:0000041 74 52 0,000 0,14369667 0,1559709 ! regulation of cellular component size GO:0032535 74 52 0,000 0,14369667 0,15589733 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,14369667 0,15582383 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,14369667 0,15575039 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,14625133 0,15844468 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,14625133 0,15837008 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,14625133 0,15829556 ! skeletal system morphogenesis GO:0048705 78 53 0,000 0,14625133 0,1582211 ! kidney development GO:0001822 90 53 0,000 0,14625133 0,15814671 ! single fertilization GO:0007338 59 53 0,000 0,14625133 0,1580724 ! amino acid transport GO:0006865 84 54 0,000 0,14879852 0,16074993 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,14879852 0,16067446 ! DNA catabolic process GO:0006308 67 54 0,000 0,14879852 0,16059906 ! detection of external stimulus GO:0009581 66 54 0,000 0,14879852 0,16052373 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,14879852 0,16044847 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,14879852 0,16037329 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,14879852 0,16029817 ! exocytosis GO:0006887 74 55 0,000 0,15133825 0,16295785 ! mesoderm development GO:0007498 76 55 0,000 0,15133825 0,1628816 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,15133825 0,16280542 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,15133825 0,1627293 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,15387055 0,16537489 ! carbohydrate transport GO:0008643 74 57 0,000 0,15639544 0,16801005 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,15639544 0,16793161 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,15639544 0,16785325 ! camera-type eye development GO:0043010 88 57 0,000 0,15639544 0,16777496 ! secondary metabolic process GO:0019748 84 57 0,000 0,15639544 0,16769674 ! developmental maturation GO:0021700 75 57 0,000 0,15639544 0,1676186 ! gonad development GO:0008406 79 57 0,000 0,15639544 0,16754053 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,15891294 0,17015818 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,15891294 0,170079 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,16142307 0,17268515 ! actin filament organization GO:0007015 95 59 0,000 0,16142307 0,17260487 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,16142307 0,17252466 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,16392586 0,17511819 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,16392586 0,17503689 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,16392586 0,17495567 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,16392586 0,17487452 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,16392586 0,17479345 ! regulation of heart contraction GO:0008016 91 60 0,000 0,16392586 0,17471245 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,16392586 0,17463153 ! fertilization GO:0009566 68 60 0,000 0,16392586 0,17455068 ! regulation of homeostatic process GO:0032844 105 60 0,000 0,16392586 0,17446991 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,16642131 0,17704395 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,16642131 0,1769621 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,16642131 0,17688032 ! urogenital system development GO:0001655 101 61 0,000 0,16642131 0,17679862 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,16642131 0,176717 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,16642131 0,17663545 ! extracellular matrix organization GO:0030198 103 61 0,000 0,16642131 0,17655398 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,16642131 0,17647258 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,16642131 0,17639125 ! amine catabolic process GO:0009310 90 62 0,000 0,16890947 0,178946 ! neurotransmitter transport GO:0006836 81 62 0,000 0,16890947 0,17886362 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,16890947 0,1787813 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,16890947 0,17869907 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,16890947 0,17861691 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,17139033 0,18115706 ! regulation of lipase activity GO:0060191 109 63 0,000 0,17139033 0,18107385 ! appendage morphogenesis GO:0035107 93 64 0,000 0,17386394 0,18360287 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,17386394 0,18351861 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,17386394 0,18343443 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,17386394 0,18335032 ! adaptive immune response GO:0002250 94 64 0,000 0,17386394 0,18326629 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,1763303 0,18578089 ! appendage development GO:0048736 94 65 0,000 0,1763303 0,18569583 GO:0060173|limb development, ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,1763303 0,18561084 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,1763303 0,18552593 ! defense response to bacterium GO:0042742 73 65 0,000 0,1763303 0,1854411 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,1763303 0,18535635 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,1763303 0,18527167 ! activation of immune response GO:0002253 83 65 0,000 0,1763303 0,18518707 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,17878944 0,18768403 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,17878944 0,18759841 ! antigen processing and presentation GO:0019882 96 66 0,000 0,17878944 0,18751286 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,17878944 0,1874274 ! regulation of immune effector process GO:0002697 101 66 0,000 0,17878944 0,18734201 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,18124137 0,18982476 ! acute inflammatory response GO:0002526 92 68 0,000 0,18368613 0,19229773 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,18368613 0,19221024 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,18368613 0,19212283 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,18368613 0,1920355 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,18368613 0,19194825 ! rhythmic process GO:0048511 105 68 0,000 0,18368613 0,19186108 ! inorganic anion transport GO:0015698 93 68 0,000 0,18368613 0,19177399 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,18612373 0,19423075 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,18612373 0,19414267 ! response to metal ion GO:0010038 103 70 0,000 0,18855419 0,19658868 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,18855419 0,19649961 ! humoral immune response GO:0006959 86 70 0,000 0,18855419 0,19641061 ! eye development GO:0001654 111 70 0,000 0,18855419 0,1963217 ! amine transport GO:0015837 101 70 0,000 0,18855419 0,19623286 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,18855419 0,19614411 ! muscle cell differentiation GO:0042692 104 71 0,000 0,19097753 0,19857519 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,19097753 0,19848545 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,19097753 0,1983958 ! steroid biosynthetic process GO:0006694 94 71 0,000 0,19097753 0,19830624 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,19339377 0,20072458 ! regulation of blood pressure GO:0008217 107 73 0,000 0,19580293 0,2031334 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,19580293 0,20304181 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,19580293 0,20295031 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,19820504 0,20534756 ! digestion GO:0007586 97 74 0,000 0,19820504 0,2052551 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,19820504 0,20516273 ! blood coagulation GO:0007596 116 75 0,000 0,2006001 0,20754846 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,2006001 0,20745514 ! response to nutrient GO:0007584 104 75 0,000 0,2006001 0,2073619 ! regulation of ligase activity GO:0051340 114 75 0,000 0,2006001 0,20726875 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,2006001 0,20717568 ! amine biosynthetic process GO:0009309 97 76 0,000 0,20298815 0,20954791 ! tRNA metabolic process GO:0006399 95 76 0,000 0,20298815 0,2094539 ! response to unfolded protein GO:0006986 99 76 0,000 0,20298815 0,20935998 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,20536921 0,21172083 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,20536921 0,21162598 ! sex differentiation GO:0007548 105 77 0,000 0,20536921 0,2115312 ! protein ubiquitination GO:0016567 125 77 0,000 0,20536921 0,21143652 ! one-carbon metabolic process GO:0006730 110 77 0,000 0,20536921 0,21134191 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,20536921 0,2112474 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,20774328 0,2135939 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,20774328 0,21349846 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,20774328 0,21340311 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,2101104 0,21573836 ! cellular respiration GO:0045333 107 79 0,000 0,2101104 0,21564209 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,2101104 0,21554591 ! regulation of lyase activity GO:0051339 133 79 0,000 0,2101104 0,21544981 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,2101104 0,2153538 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,21247059 0,21767588 GO:0010498|proteasomal protein catabolic process, ! regulation of GTPase activity GO:0043087 129 80 0,000 0,21247059 0,21757896 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,21482385 0,2198909 ! hemostasis GO:0007599 125 81 0,000 0,21482385 0,21979309 ! mRNA transport GO:0051028 121 81 0,000 0,21482385 0,21969536 ! response to protein stimulus GO:0051789 111 81 0,000 0,21482385 0,21959771 ! regulation of neurological system process GO:0031644 122 81 0,000 0,21482385 0,21950016 ! vitamin metabolic process GO:0006766 103 81 0,000 0,21482385 0,21940269 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,21482385 0,21930531 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,21717022 0,22160227 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 0,000 0,21717022 0,22150399 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,21950971 0,22379093 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,21950971 0,22369178 ! regulation of defense response GO:0031347 117 84 0,000 0,22184235 0,22596873 ! sterol metabolic process GO:0016125 120 84 0,000 0,22184235 0,2258687 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,22416814 0,22813572 ! rRNA metabolic process GO:0016072 107 85 0,000 0,22416814 0,22803482 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 0,000 0,22416814 0,22793401 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,22416814 0,22783329 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,22648712 0,2300885 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,2287993 0,23233483 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,2287993 0,2322323 ! female pregnancy GO:0007565 130 87 0,000 0,2287993 0,23212986 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,2311047 0,23436543 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,2311047 0,23426214 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,2311047 0,23415895 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,2311047 0,23405584 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 0,000 0,2311047 0,23395282 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,23340334 0,23617584 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,23340334 0,23607198 ! protein modification by small protein conjugation GO:0032446 140 90 0,000 0,23569524 0,2382853 ! RNA localization GO:0006403 135 91 0,000 0,23798042 0,24048988 ! ATP metabolic process GO:0046034 137 91 0,000 0,23798042 0,24038426 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,2402589 0,24257922 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,2402589 0,24247278 ! positive regulation of immune response GO:0050778 121 92 0,000 0,2402589 0,24236643 ! DNA recombination GO:0006310 146 92 0,000 0,2402589 0,24226018 ! sulfur metabolic process GO:0006790 118 92 0,000 0,2402589 0,24215402 ! regulation of cytoskeleton organization GO:0051493 154 93 0,000 0,24253069 0,24433666 ! electron transport chain GO:0022900 123 94 0,000 0,24479583 0,24651068 ! response to oxidative stress GO:0006979 141 94 0,000 0,24479583 0,2464028 ! carboxylic acid transport GO:0046942 147 95 0,000 0,24705432 0,24856734 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,24930618 0,25072331 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,24930618 0,25061373 ! protein modification by small protein conjugation or removal GO:0070647 148 96 0,000 0,24930618 0,25050425 ! protein maturation GO:0051604 129 96 0,000 0,24930618 0,25039486 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,25155144 0,25253964 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,25155144 0,25242946 ! calcium ion transport GO:0006816 167 99 0,000 0,25602222 0,2568038 ! regulation of translation GO:0006417 151 100 0,000 0,25824778 0,25892323 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,25824778 0,25881041 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,25824778 0,25869768 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,25824778 0,25858506 ! divalent metal ion transport GO:0070838 171 100 0,000 0,25824778 0,25847253 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,25824778 0,25836011 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,25824778 0,25824778