pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6134-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! interphase of mitotic cell cycle GO:0051329 156 86 8,000 5,191E-08 1,194E-04 ! interphase GO:0051325 159 88 8,000 6,356E-08 7,31E-05 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 6,000 7,401E-08 5,674E-05 ! G1 DNA damage checkpoint GO:0031571 18 7 3,000 1,786E-07 1,027E-04 ! apoptotic mitochondrial changes GO:0008637 29 18 4,000 3,406E-07 1,567E-04 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 3,000 1,051E-06 4,027E-04 ! induction of apoptosis by intracellular signals GO:0008629 67 40 5,000 1,089E-06 3,578E-04 ! cell cycle checkpoint GO:0000075 108 64 6,000 1,227E-06 3,529E-04 ! mitochondrion organization GO:0007005 104 73 6,000 3,019E-06 7,714E-04 ! ear development GO:0043583 72 50 5,000 4,201E-06 9,663E-04 ! G1/S transition checkpoint GO:0031575 33 14 3,000 4,875E-06 1,019E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 3,000 4,875E-06 9,344E-04 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 2,000 6,114E-06 1,082E-03 ! DNA damage checkpoint GO:0000077 53 31 4,000 6,174E-06 1,014E-03 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 4,000 6,174E-06 9,466E-04 ! cell cycle arrest GO:0007050 150 86 6,000 9,071E-06 1,304E-03 ! mitotic cell cycle checkpoint GO:0007093 63 34 4,000 9,903E-06 1,34E-03 ! DNA integrity checkpoint GO:0031570 57 34 4,000 9,903E-06 1,265E-03 ! positive regulation of protein ubiquitination GO:0031398 8 6 2,000 1,215E-05 1,471E-03 ! negative regulation of cell growth GO:0030308 106 62 5,000 1,494E-05 1,718E-03 ! negative regulation of cell size GO:0045792 108 64 5,000 1,796E-05 1,967E-03 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 2,000 2,113E-05 2,209E-03 ! B cell lineage commitment GO:0002326 17 7 2,000 2,113E-05 2,113E-03 ! T cell lineage commitment GO:0002360 12 7 2,000 2,113E-05 2,025E-03 ! ATP synthesis coupled electron transport GO:0042773 48 40 4,000 2,247E-05 2,067E-03 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! microtubule-based transport GO:0010970 37 20 3,000 2,267E-05 2,005E-03 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 5,000 3,266E-05 2,782E-03 ! middle ear morphogenesis GO:0042474 9 8 2,000 3,36E-05 2,76E-03 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 2,000 3,36E-05 2,665E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 3,36E-05 2,576E-03 ! regulation of mitochondrial membrane potential GO:0051881 11 8 2,000 3,36E-05 2,493E-03 ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 3,000 3,377E-05 2,427E-03 ! positive regulation of cell cycle GO:0045787 77 45 4,000 4,03E-05 2,809E-03 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 3,000 4,061E-05 2,747E-03 ! negative regulation of growth GO:0045926 123 75 5,000 4,464E-05 2,934E-03 ! regulation of ligase activity GO:0051340 114 75 5,000 4,464E-05 2,852E-03 ! mitochondrial membrane organization GO:0007006 39 24 3,000 4,841E-05 3,009E-03 ! respiratory electron transport chain GO:0022904 59 47 4,000 4,991E-05 3,021E-03 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 4,000 7,435E-05 4,385E-03 ! response to ionizing radiation GO:0010212 47 27 3,000 7,836E-05 4,506E-03 ! focal adhesion formation GO:0048041 24 11 2,000 9,713E-05 5,449E-03 ! negative regulation of mast cell proliferation GO:0070667 17 11 2,000 9,713E-05 5,319E-03 GO:0042130|negative regulation of T cell proliferation, ! DNA damage response, signal transduction GO:0042770 96 56 4,000 1,168E-04 6,248E-03 ! response to gamma radiation GO:0010332 20 12 2,000 1,287E-04 6,727E-03 ! nucleus organization GO:0006997 49 33 3,000 1,756E-04 8,973E-03 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 4,000 1,758E-04 8,789E-03 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 4,000 1,899E-04 9,292E-03 ! axon cargo transport GO:0008088 27 14 2,000 2,103E-04 0,01007529 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 4,000 2,207E-04 0,01035816 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 4,000 2,374E-04 0,0109216 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 4,000 2,374E-04 0,01070745 ! regulation of protein ubiquitination GO:0031396 19 15 2,000 2,612E-04 0,01155232 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 2,000 2,612E-04 0,01133435 ! negative regulation of leukocyte proliferation GO:0070664 25 15 2,000 2,612E-04 0,01112446 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! positive regulation of neuron apoptosis GO:0043525 29 15 2,000 2,612E-04 0,01092219 ! mesenchymal cell development GO:0014031 64 38 3,000 3,063E-04 0,01258078 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! response to drug GO:0042493 108 69 4,000 3,143E-04 0,01268186 ! positive regulation of ligase activity GO:0051351 99 69 4,000 3,143E-04 0,0124632 ! G1 phase GO:0051318 27 16 2,000 3,194E-04 0,01245265 ! inner ear receptor cell differentiation GO:0060113 30 16 2,000 3,194E-04 0,01224511 ! positive regulation of phosphorylation GO:0042327 102 70 4,000 3,361E-04 0,01267449 ! regulation of epithelial cell proliferation GO:0050678 71 39 3,000 3,391E-04 0,01257802 ! cell growth GO:0016049 61 39 3,000 3,391E-04 0,01237837 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 3,000 3,742E-04 0,01344913 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 4,000 3,833E-04 0,01356303 GO:0045937|positive regulation of phosphate metabolic process, ! cell-substrate junction assembly GO:0007044 39 17 2,000 3,855E-04 0,01343249 ! proximal/distal pattern formation GO:0009954 25 17 2,000 3,855E-04 0,013232 ! mitochondrial transport GO:0006839 60 42 3,000 4,523E-04 0,0152982 ! branching morphogenesis of a tube GO:0048754 72 42 3,000 4,523E-04 0,01507649 ! mechanoreceptor differentiation GO:0042490 32 18 2,000 4,596E-04 0,01510255 ! negative regulation of T cell activation GO:0050868 25 18 2,000 4,596E-04 0,01488984 ! activation of caspase activity GO:0006919 65 43 3,000 4,954E-04 0,0158247 ! response to alkaloid GO:0043279 32 19 2,000 5,424E-04 0,0170894 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 2,000 5,424E-04 0,01685846 ! cell structure disassembly during apoptosis GO:0006921 24 19 2,000 5,424E-04 0,01663368 ! apoptotic nuclear changes GO:0030262 24 19 2,000 5,424E-04 0,01641482 ! renal system process GO:0003014 35 19 2,000 5,424E-04 0,01620164 ! positive regulation of protein modification process GO:0031401 107 78 4,000 5,55E-04 0,01636611 ! cellular respiration GO:0045333 107 79 4,000 5,885E-04 0,0171329 ! oxidative phosphorylation GO:0006119 105 79 4,000 5,885E-04 0,01691874 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 4,000 6,234E-04 0,0177021 GO:0010498|proteasomal protein catabolic process, ! response to UV GO:0009411 75 46 3,000 6,421E-04 0,0180108 ! regulation of neuron apoptosis GO:0043523 77 47 3,000 6,972E-04 0,01932039 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 1,000 7,19E-04 0,01968786 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! traversing start control point of mitotic cell cycle GO:0007089 11 5 1,000 7,19E-04 0,01945624 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 1,000 7,19E-04 0,01923001 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 7,19E-04 0,01900897 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 1,000 7,19E-04 0,01879296 ! peptidyl-threonine phosphorylation GO:0018107 14 5 1,000 7,19E-04 0,0185818 ! homeostasis of number of cells within a tissue GO:0048873 9 5 1,000 7,19E-04 0,01837534 ! triglyceride catabolic process GO:0019433 6 5 1,000 7,19E-04 0,01817341 ! regulation of mitochondrial depolarization GO:0051900 9 5 1,000 7,19E-04 0,01797588 ! hemopoietic progenitor cell differentiation GO:0002244 10 5 1,000 7,19E-04 0,01778259 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 2,000 7,352E-04 0,01798823 ! DNA catabolic process, endonucleolytic GO:0000737 26 21 2,000 7,352E-04 0,01779888 ! activation of pro-apoptotic gene products GO:0008633 36 21 2,000 7,352E-04 0,01761348 ! cell aging GO:0007569 32 21 2,000 7,352E-04 0,0174319 ! response to endoplasmic reticulum stress GO:0034976 25 21 2,000 7,352E-04 0,01725402 ! regulation of vasoconstriction GO:0019229 31 21 2,000 7,352E-04 0,01707974 ! response to cytokine stimulus GO:0034097 47 21 2,000 7,352E-04 0,01690894 ! regulation of cell adhesion GO:0030155 159 83 4,000 7,376E-04 0,0167973 ! positive regulation of caspase activity GO:0043280 72 48 3,000 7,556E-04 0,0170373 GO:0010952|positive regulation of peptidase activity, ! morphogenesis of a branching structure GO:0001763 86 49 3,000 8,173E-04 0,01825015 ! regulation of membrane potential GO:0042391 128 85 4,000 8,22E-04 0,01817857 ! regulation of cell-matrix adhesion GO:0001952 51 22 2,000 8,459E-04 0,01852965 GO:0010810|regulation of cell-substrate adhesion, ! protein tetramerization GO:0051262 39 22 2,000 8,459E-04 0,01835484 ! female pregnancy GO:0007565 130 87 4,000 9,134E-04 0,01963276 ! ER-nuclear signaling pathway GO:0006984 27 23 2,000 9,667E-04 0,02058745 ! aging GO:0007568 79 52 3,000 1,024E-03 0,0216016 ! regulation of helicase activity GO:0051095 11 6 1,000 1,072E-03 0,02242452 ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 1,000 1,072E-03 0,02222249 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 1,072E-03 0,02202408 ! neuron adhesion GO:0007158 9 6 1,000 1,072E-03 0,02182917 ! inositol phosphate-mediated signaling GO:0048016 9 6 1,000 1,072E-03 0,02163769 ! pigment granule organization GO:0048753 11 6 1,000 1,072E-03 0,02144954 ! activation of caspase activity by cytochrome c GO:0008635 10 6 1,000 1,072E-03 0,02126463 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 1,000 1,072E-03 0,02108288 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! ER overload response GO:0006983 7 6 1,000 1,072E-03 0,02090421 ! vascular smooth muscle contraction GO:0014829 10 6 1,000 1,072E-03 0,02072854 ! positive regulation of muscle hypertrophy GO:0014742 9 6 1,000 1,072E-03 0,02055581 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 1,000 1,072E-03 0,02038592 ! maintenance of protein location in nucleus GO:0051457 16 6 1,000 1,072E-03 0,02021883 ! glycerol ether catabolic process GO:0044269 8 6 1,000 1,072E-03 0,02005444 GO:0046464|acylglycerol catabolic process, ! protein import into mitochondrial inner membrane GO:0045039 6 6 1,000 1,072E-03 0,01989272 ! enucleate erythrocyte differentiation GO:0043353 9 6 1,000 1,072E-03 0,01973357 ! dendrite morphogenesis GO:0048813 9 6 1,000 1,072E-03 0,01957696 ! regulation of myeloid cell apoptosis GO:0033032 10 6 1,000 1,072E-03 0,01942281 ! negative regulation of neuroblast proliferation GO:0007406 18 6 1,000 1,072E-03 0,01927107 ! axonal fasciculation GO:0007413 9 6 1,000 1,072E-03 0,01912168 ! progesterone metabolic process GO:0042448 8 6 1,000 1,072E-03 0,01897459 ! aspartate family amino acid catabolic process GO:0009068 7 6 1,000 1,072E-03 0,01882975 ! positive regulation of smooth muscle contraction GO:0045987 9 6 1,000 1,072E-03 0,0186871 ! negative regulation of B cell activation GO:0050869 9 6 1,000 1,072E-03 0,01854659 ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 2,000 1,098E-03 0,01884459 ! regulation of chromosome organization GO:0033044 35 25 2,000 1,24E-03 0,02112269 ! positive regulation of nuclear division GO:0051785 39 25 2,000 1,24E-03 0,02096738 GO:0045840|positive regulation of mitosis, ! negative regulation of lymphocyte activation GO:0051250 37 25 2,000 1,24E-03 0,02081433 ! electron transport chain GO:0022900 123 94 4,000 1,293E-03 0,0215565 ! translational initiation GO:0006413 43 26 2,000 1,393E-03 0,02304565 ! regulation of pH GO:0006885 36 26 2,000 1,393E-03 0,02288104 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 1,445E-03 0,02357174 ! neutral lipid catabolic process GO:0046461 9 7 1,000 1,493E-03 0,02418264 ! regulation of lipid kinase activity GO:0043550 12 7 1,000 1,493E-03 0,02401353 ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 1,493E-03 0,02384677 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 1,493E-03 0,02368231 ! estrogen metabolic process GO:0008210 14 7 1,000 1,493E-03 0,0235201 ! positive regulation of heart rate GO:0010460 9 7 1,000 1,493E-03 0,0233601 ! glycerolipid catabolic process GO:0046503 9 7 1,000 1,493E-03 0,02320226 ! regulation of pigmentation during development GO:0048070 15 7 1,000 1,493E-03 0,02304654 ! phasic smooth muscle contraction GO:0014821 12 7 1,000 1,493E-03 0,0228929 ! central nervous system neuron axonogenesis GO:0021955 14 7 1,000 1,493E-03 0,02274129 GO:0021952|central nervous system projection neuron axonogenesis, ! organ growth GO:0035265 11 7 1,000 1,493E-03 0,02259168 ! behavioral fear response GO:0001662 13 7 1,000 1,493E-03 0,02244402 GO:0002209|behavioral defense response, ! response to UV-B GO:0010224 11 7 1,000 1,493E-03 0,02229828 ! mast cell activation GO:0045576 9 7 1,000 1,493E-03 0,02215442 ! response to tumor cell GO:0002347 12 7 1,000 1,493E-03 0,0220124 ! peptidyl-threonine modification GO:0018210 18 7 1,000 1,493E-03 0,0218722 ! diuresis GO:0030146 12 7 1,000 1,493E-03 0,02173376 GO:0030147|natriuresis, ! regulation of protein homodimerization activity GO:0043496 15 7 1,000 1,493E-03 0,02159707 ! trophectodermal cell differentiation GO:0001829 8 7 1,000 1,493E-03 0,02146209 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 1,000 1,493E-03 0,02132879 ! steroid hormone receptor signaling pathway GO:0030518 96 58 3,000 1,542E-03 0,02189051 ! negative regulation of leukocyte activation GO:0002695 39 27 2,000 1,557E-03 0,02197076 ! cell junction assembly GO:0034329 56 28 2,000 1,733E-03 0,02430437 ! negative regulation of ligase activity GO:0051352 91 61 3,000 1,859E-03 0,02591654 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! tissue homeostasis GO:0001894 42 29 2,000 1,921E-03 0,02661481 GO:0048871|multicellular organismal homeostasis, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 1,979E-03 0,02726241 ! axon extension GO:0048675 11 8 1,000 1,979E-03 0,02710013 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 1,000 1,979E-03 0,02693978 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,979E-03 0,02678131 ! inner mitochondrial membrane organization GO:0007007 11 8 1,000 1,979E-03 0,02662469 ! melanin metabolic process GO:0006582 12 8 1,000 1,979E-03 0,0264699 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 1,000 1,979E-03 0,02631689 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,979E-03 0,02616564 ! regulation of muscle hypertrophy GO:0014743 11 8 1,000 1,979E-03 0,02601613 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! oligodendrocyte development GO:0014003 8 8 1,000 1,979E-03 0,02586831 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 1,979E-03 0,02572216 ! regulation of macrophage differentiation GO:0045649 14 8 1,000 1,979E-03 0,02557765 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,979E-03 0,02543476 ! regulation of embryonic development GO:0045995 16 8 1,000 1,979E-03 0,02529346 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 3,000 2,094E-03 0,02661297 ! negative regulation of cell activation GO:0050866 44 30 2,000 2,121E-03 0,02680385 ! response to heat GO:0009408 41 30 2,000 2,121E-03 0,02665738 ! regulation of striated muscle tissue development GO:0016202 47 31 2,000 2,334E-03 0,02916992 ! regulation of caspase activity GO:0043281 97 65 3,000 2,349E-03 0,02920614 ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 1,000 2,531E-03 0,03129419 ! T cell selection GO:0045058 18 9 1,000 2,531E-03 0,03112684 ! positive regulation of muscle contraction GO:0045933 12 9 1,000 2,531E-03 0,03096128 ! motor axon guidance GO:0008045 14 9 1,000 2,531E-03 0,03079746 ! alpha-beta T cell differentiation GO:0046632 14 9 1,000 2,531E-03 0,03063537 ! renal water homeostasis GO:0003091 14 9 1,000 2,531E-03 0,03047497 ! postreplication repair GO:0006301 11 9 1,000 2,531E-03 0,03031625 ! oocyte differentiation GO:0009994 12 9 1,000 2,531E-03 0,03015917 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 1,000 2,531E-03 0,03000371 ! spleen development GO:0048536 15 9 1,000 2,531E-03 0,02984985 ! blastocyst formation GO:0001825 12 9 1,000 2,531E-03 0,02969755 ! regulation of muscle adaptation GO:0043502 12 9 1,000 2,531E-03 0,0295468 ! embryonic placenta development GO:0001892 12 9 1,000 2,531E-03 0,02939758 ! response to nicotine GO:0035094 16 9 1,000 2,531E-03 0,02924985 ! regulation of muscle development GO:0048634 48 32 2,000 2,559E-03 0,02942774 ! monovalent inorganic cation homeostasis GO:0055067 45 32 2,000 2,559E-03 0,02928133 ! regulation of protein stability GO:0031647 48 32 2,000 2,559E-03 0,02913637 ! regulation of endopeptidase activity GO:0052548 99 67 3,000 2,625E-03 0,02973727 ! ear morphogenesis GO:0042471 42 33 2,000 2,797E-03 0,03153787 ! cell junction organization GO:0034330 63 33 2,000 2,797E-03 0,03138402 ! androgen receptor signaling pathway GO:0030521 54 33 2,000 2,797E-03 0,03123167 ! neuron migration GO:0001764 46 34 2,000 3,049E-03 0,0338761 ! response to metal ion GO:0010038 103 70 3,000 3,078E-03 0,03403734 ! humoral immune response GO:0006959 86 70 3,000 3,078E-03 0,03387449 ! cortical actin cytoskeleton organization GO:0030866 19 10 1,000 3,146E-03 0,03445249 ! regulation of B cell proliferation GO:0030888 15 10 1,000 3,146E-03 0,03428921 ! hair follicle morphogenesis GO:0031069 17 10 1,000 3,146E-03 0,03412747 ! positive regulation of heart contraction GO:0045823 14 10 1,000 3,146E-03 0,03396724 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 1,000 3,146E-03 0,03380852 GO:0010812|negative regulation of cell-substrate adhesion, ! pathogenesis GO:0009405 13 10 1,000 3,146E-03 0,03365127 ! response to X-ray GO:0010165 16 10 1,000 3,146E-03 0,03349548 ! B cell proliferation GO:0042100 14 10 1,000 3,146E-03 0,03334112 ! fear response GO:0042596 16 10 1,000 3,146E-03 0,03318818 ! negative regulation of ossification GO:0030279 19 10 1,000 3,146E-03 0,03303664 ! alpha-beta T cell activation GO:0046631 16 10 1,000 3,146E-03 0,03288647 ! DNA methylation GO:0006306 15 10 1,000 3,146E-03 0,03273766 GO:0006305|DNA alkylation, ! multicellular organismal water homeostasis GO:0050891 15 10 1,000 3,146E-03 0,03259019 ! regulation of peptidase activity GO:0052547 106 72 3,000 3,409E-03 0,03515554 ! response to hypoxia GO:0001666 132 72 3,000 3,409E-03 0,0349986 ! tube morphogenesis GO:0035239 118 73 3,000 3,582E-03 0,03662076 ! response to reactive oxygen species GO:0000302 55 36 2,000 3,593E-03 0,03656228 ! response to oxygen levels GO:0070482 137 74 3,000 3,762E-03 0,03812026 ! cortical cytoskeleton organization GO:0030865 20 11 1,000 3,823E-03 0,03856649 ! detection of mechanical stimulus GO:0050982 15 11 1,000 3,823E-03 0,03839808 ! regulation of mRNA processing GO:0050684 18 11 1,000 3,823E-03 0,03823113 ! oligodendrocyte differentiation GO:0048709 14 11 1,000 3,823E-03 0,03806563 ! regulation of intracellular pH GO:0051453 17 11 1,000 3,823E-03 0,03790155 ! vasoconstriction GO:0042310 15 11 1,000 3,823E-03 0,03773888 ! T cell homeostasis GO:0043029 20 11 1,000 3,823E-03 0,03757761 ! digestive tract morphogenesis GO:0048546 15 11 1,000 3,823E-03 0,0374177 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! response to inorganic substance GO:0010035 115 75 3,000 3,948E-03 0,03847792 ! regulation of T cell proliferation GO:0042129 58 38 2,000 4,192E-03 0,04068248 ! pigmentation GO:0043473 74 38 2,000 4,192E-03 0,04051155 ! regulation of skeletal muscle fiber development GO:0048742 20 12 1,000 4,562E-03 0,04390206 ! gland morphogenesis GO:0022612 23 12 1,000 4,562E-03 0,04371913 ! cAMP biosynthetic process GO:0006171 20 12 1,000 4,562E-03 0,04353772 ! inner ear development GO:0048839 57 40 2,000 4,849E-03 0,04608303 ! T cell differentiation GO:0030217 65 40 2,000 4,849E-03 0,04589339 ! B cell differentiation GO:0030183 62 40 2,000 4,849E-03 0,0457053 ! JAK-STAT cascade GO:0007259 53 40 2,000 4,849E-03 0,04551875 ! forebrain development GO:0030900 131 80 3,000 4,971E-03 0,04647819 ! regulation of cell cycle process GO:0010564 122 81 3,000 5,195E-03 0,04837548 ! glucose transport GO:0015758 52 41 2,000 5,199E-03 0,04821661 ! regulation of T cell differentiation GO:0045580 59 41 2,000 5,199E-03 0,04802297 ! response to hexose stimulus GO:0009746 19 13 1,000 5,361E-03 0,04932324 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! negative regulation of mitotic cell cycle GO:0045930 23 13 1,000 5,361E-03 0,04912674 ! bone mineralization GO:0030282 15 13 1,000 5,361E-03 0,04893179 ! regulation of cellular pH GO:0030641 20 13 1,000 5,361E-03 0,04873838 ! cellular pigmentation GO:0033059 24 13 1,000 5,361E-03 0,0485465 ! lymphocyte homeostasis GO:0002260 24 13 1,000 5,361E-03 0,04835612 ! cellular component disassembly GO:0022411 64 42 2,000 5,564E-03 0,04999033 ! hexose transport GO:0008645 54 42 2,000 5,564E-03 0,04979581 GO:0015749|monosaccharide transport, ! regulation of DNA metabolic process GO:0051052 135 85 3,000 6,158E-03 0,05490079 ! Golgi vesicle transport GO:0048193 138 85 3,000 6,158E-03 0,05468882 ! negative regulation of multicellular organismal process GO:0051241 133 85 3,000 6,158E-03 0,05447848 ! regulation of skeletal muscle tissue development GO:0048641 22 14 1,000 6,22E-03 0,05480975 ! G1 phase of mitotic cell cycle GO:0000080 23 14 1,000 6,22E-03 0,05460055 ! negative regulation of bone remodeling GO:0046851 26 14 1,000 6,22E-03 0,05439294 ! epidermis morphogenesis GO:0048730 29 14 1,000 6,22E-03 0,05418691 ! cellular response to starvation GO:0009267 21 14 1,000 6,22E-03 0,05398243 ! regulation of heart rate GO:0002027 23 14 1,000 6,22E-03 0,05377949 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 1,000 6,22E-03 0,05357807 GO:0060675|ureteric bud morphogenesis, ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 1,000 6,22E-03 0,05337815 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 6,22E-03 0,05317972 ! negative regulation of blood coagulation GO:0030195 19 14 1,000 6,22E-03 0,05298275 ! water homeostasis GO:0030104 24 14 1,000 6,22E-03 0,05278725 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 1,000 6,22E-03 0,05259317 ! regulation of ATPase activity GO:0043462 18 14 1,000 6,22E-03 0,05240053 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 6,22E-03 0,05220928 ! peptide hormone secretion GO:0030072 23 14 1,000 6,22E-03 0,05201943 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 6,34E-03 0,05283032 ! protein amino acid autophosphorylation GO:0046777 80 45 2,000 6,75E-03 0,05604953 ! positive regulation of cell size GO:0045793 20 15 1,000 7,136E-03 0,05904226 ! metencephalon development GO:0022037 19 15 1,000 7,136E-03 0,05883063 ! negative regulation of hormone secretion GO:0046888 20 15 1,000 7,136E-03 0,05862052 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 7,136E-03 0,05841191 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 7,136E-03 0,05820478 ! regulation of muscle cell differentiation GO:0051147 24 15 1,000 7,136E-03 0,05799911 ! regulation of survival gene product expression GO:0045884 20 15 1,000 7,136E-03 0,05779488 ! peptidyl-serine phosphorylation GO:0018105 23 15 1,000 7,136E-03 0,05759209 ! peptide secretion GO:0002790 27 15 1,000 7,136E-03 0,05739072 ! neuron recognition GO:0008038 22 15 1,000 7,136E-03 0,05719076 ! negative regulation of tissue remodeling GO:0034104 27 15 1,000 7,136E-03 0,05699218 ! biomineral formation GO:0031214 18 15 1,000 7,136E-03 0,05679497 ! defense response to virus GO:0051607 27 15 1,000 7,136E-03 0,05659913 ! regulation of neurogenesis GO:0050767 153 89 3,000 7,234E-03 0,0571743 ! negative regulation of immune system process GO:0002683 73 47 2,000 7,618E-03 0,06000662 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 7,618E-03 0,05980182 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! response to temperature stimulus GO:0009266 62 48 2,000 8,076E-03 0,06317758 ! regulation of DNA replication GO:0006275 75 48 2,000 8,076E-03 0,06296342 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 2,000 8,076E-03 0,06275071 ! regulation of lymphocyte differentiation GO:0045619 69 48 2,000 8,076E-03 0,06253943 ! hormone secretion GO:0046879 25 16 1,000 8,11E-03 0,06259601 ! glial cell development GO:0021782 24 16 1,000 8,11E-03 0,06238666 ! patterning of blood vessels GO:0001569 24 16 1,000 8,11E-03 0,0621787 ! cellular response to unfolded protein GO:0034620 19 16 1,000 8,11E-03 0,06197213 GO:0030968|endoplasmic reticulum unfolded protein response, ! regulation of protein binding GO:0043393 27 16 1,000 8,11E-03 0,06176692 ! oogenesis GO:0048477 23 16 1,000 8,11E-03 0,06156307 ! neutrophil chemotaxis GO:0030593 21 16 1,000 8,11E-03 0,06136056 ! protein localization in mitochondrion GO:0070585 22 16 1,000 8,11E-03 0,06115938 GO:0006626|protein targeting to mitochondrion, ! regulation of angiogenesis GO:0045765 94 49 2,000 8,549E-03 0,0642581 ! response to oxidative stress GO:0006979 141 94 3,000 8,743E-03 0,06550391 ! positive regulation of hormone secretion GO:0046887 24 17 1,000 9,14E-03 0,06825504 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 1,000 9,14E-03 0,06803415 ! regulation of viral genome replication GO:0045069 24 17 1,000 9,14E-03 0,06781468 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 9,14E-03 0,06759663 ! actin filament bundle formation GO:0051017 26 17 1,000 9,14E-03 0,06737997 ! neuromuscular junction development GO:0007528 23 17 1,000 9,14E-03 0,0671647 ! body fluid secretion GO:0007589 27 17 1,000 9,14E-03 0,0669508 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 9,14E-03 0,06673826 ! peptidyl-serine modification GO:0018209 27 17 1,000 9,14E-03 0,06652706 ! negative regulation of homeostatic process GO:0032845 28 17 1,000 9,14E-03 0,0663172 ! negative regulation of coagulation GO:0050819 23 17 1,000 9,14E-03 0,06610865 ! in utero embryonic development GO:0001701 147 96 3,000 9,401E-03 0,06777836 ! response to light stimulus GO:0009416 153 96 3,000 9,401E-03 0,06756655 ! positive regulation of cell migration GO:0030335 92 51 2,000 9,544E-03 0,06838331 ! positive regulation of organelle organization GO:0010638 82 51 2,000 9,544E-03 0,06817094 ! positive regulation of anti-apoptosis GO:0045768 29 18 1,000 0,01022531 0,07281184 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 0,01022531 0,07258711 ! cAMP metabolic process GO:0046058 33 18 1,000 0,01022531 0,07236377 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 1,000 0,01022531 0,07214179 GO:0050886|endocrine process, ! response to carbohydrate stimulus GO:0009743 24 18 1,000 0,01022531 0,07192117 ! central nervous system neuron development GO:0021954 30 18 1,000 0,01022531 0,0717019 ! positive regulation of cytoskeleton organization GO:0051495 33 18 1,000 0,01022531 0,07148396 ! cellular response to nutrient levels GO:0031669 27 18 1,000 0,01022531 0,07126734 ! hormone transport GO:0009914 27 18 1,000 0,01022531 0,07105204 ! gut development GO:0048565 26 18 1,000 0,01022531 0,07083802 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 0,01022531 0,0706253 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 1,000 0,01022531 0,07041384 ! protein localization in organelle GO:0033365 161 100 3,000 0,01080966 0,07421557 ! regulation of mitosis GO:0007088 84 54 2,000 0,01115783 0,07637799 GO:0051783|regulation of nuclear division, ! DNA catabolic process GO:0006308 67 54 2,000 0,01115783 0,07615135 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 0,01136448 0,07733227 ! C21-steroid hormone metabolic process GO:0008207 23 19 1,000 0,01136448 0,07710415 ! regeneration GO:0031099 32 19 1,000 0,01136448 0,07687737 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 0,01136448 0,07665192 ! smooth muscle contraction GO:0006939 36 19 1,000 0,01136448 0,07642779 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 0,01136448 0,07620497 ! response to starvation GO:0042594 30 19 1,000 0,01136448 0,07598345 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 0,01136448 0,07576321 ! negative regulation of angiogenesis GO:0016525 36 19 1,000 0,01136448 0,07554424 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 1,000 0,01136448 0,07532653 ! positive regulation of cell motion GO:0051272 99 56 2,000 0,01231593 0,0813984 ! response to ethanol GO:0045471 37 20 1,000 0,01255674 0,08275217 ! multicellular organismal response to stress GO:0033555 32 20 1,000 0,01255674 0,08251574 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 0,01255674 0,08228065 ! central nervous system neuron differentiation GO:0021953 33 20 1,000 0,01255674 0,0820469 ! fatty acid beta-oxidation GO:0006635 31 20 1,000 0,01255674 0,08181447 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 0,01255674 0,08158336 ! DNA modification GO:0006304 28 20 1,000 0,01255674 0,08135355 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 0,01291987 0,08347107 ! carbohydrate transport GO:0008643 74 57 2,000 0,01291987 0,08323725 ! multicellular organism reproduction GO:0032504 83 57 2,000 0,01291987 0,08300475 GO:0048609|reproductive process in a multicellular organism, ! negative regulation of kinase activity GO:0033673 100 58 2,000 0,01354049 0,08674965 ! dendrite development GO:0016358 35 21 1,000 0,01380112 0,08817382 ! ovarian follicle development GO:0001541 30 21 1,000 0,01380112 0,08792957 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 1,000 0,01380112 0,08768667 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 0,01380112 0,08744511 ! response to glucocorticoid stimulus GO:0051384 33 21 1,000 0,01380112 0,08720487 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 2,000 0,01417785 0,08933987 ! actin filament organization GO:0007015 95 59 2,000 0,01417785 0,08909578 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 0,01483201 0,09295264 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 2,000 0,01483201 0,09270005 ! regulation of homeostatic process GO:0032844 105 60 2,000 0,01483201 0,09244883 ! protein import into nucleus, translocation GO:0000060 36 22 1,000 0,01509664 0,09384397 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01509664 0,09359102 ! regulation of anti-apoptosis GO:0045767 36 22 1,000 0,01509664 0,09333944 ! molting cycle process GO:0022404 40 22 1,000 0,01509664 0,0930892 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 1,000 0,01509664 0,09284029 ! vasculogenesis GO:0001570 33 22 1,000 0,01509664 0,09259272 ! regulation of smooth muscle contraction GO:0006940 36 22 1,000 0,01509664 0,09234646 ! ureteric bud development GO:0001657 32 22 1,000 0,01509664 0,09210151 ! membrane depolarization GO:0051899 35 22 1,000 0,01509664 0,09185786 ! leukocyte homeostasis GO:0001776 33 22 1,000 0,01509664 0,09161549 ! regulation of blood coagulation GO:0030193 34 22 1,000 0,01509664 0,09137439 ! aspartate family amino acid metabolic process GO:0009066 24 22 1,000 0,01509664 0,09113457 ! blastocyst development GO:0001824 37 22 1,000 0,01509664 0,09089599 ! positive regulation of JUN kinase activity GO:0043507 28 22 1,000 0,01509664 0,09065867 ! cell-matrix adhesion GO:0007160 114 61 2,000 0,01550301 0,09285659 ! homeostasis of number of cells GO:0048872 84 61 2,000 0,01550301 0,09261541 ! negative regulation of transferase activity GO:0051348 105 61 2,000 0,01550301 0,09237547 ! cellular hormone metabolic process GO:0034754 87 62 2,000 0,01619091 0,09622506 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01644235 0,09746752 ! myelination GO:0042552 35 23 1,000 0,01644235 0,09721696 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01644235 0,09696768 ! negative regulation of DNA replication GO:0008156 35 23 1,000 0,01644235 0,09671968 ! response to corticosteroid stimulus GO:0031960 36 23 1,000 0,01644235 0,09647295 ! regulation of viral reproduction GO:0050792 32 23 1,000 0,01644235 0,09622747 ! lymphocyte proliferation GO:0046651 36 23 1,000 0,01644235 0,09598324 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01644235 0,09574024 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 0,01644235 0,09549847 ! negative regulation of phosphorylation GO:0042326 41 23 1,000 0,01644235 0,09525792 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 0,01689574 0,0976387 ! appendage morphogenesis GO:0035107 93 64 2,000 0,01761754 0,10155472 GO:0035108|limb morphogenesis, ! insulin receptor signaling pathway GO:0008286 40 24 1,000 0,0178373 0,10256445 ! fat cell differentiation GO:0045444 37 24 1,000 0,0178373 0,10230868 ! neural crest cell development GO:0014032 39 24 1,000 0,0178373 0,10205418 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 1,000 0,0178373 0,10180094 ! negative regulation of cell development GO:0010721 56 24 1,000 0,0178373 0,10154896 GO:0050768|negative regulation of neurogenesis, ! base-excision repair GO:0006284 31 24 1,000 0,0178373 0,10129822 ! regulation of JUN kinase activity GO:0043506 34 24 1,000 0,0178373 0,10104872 ! appendage development GO:0048736 94 65 2,000 0,01835633 0,10373355 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 2,000 0,01835633 0,1034793 ! protein oligomerization GO:0051259 100 65 2,000 0,01835633 0,10322629 ! cell-substrate adhesion GO:0031589 121 66 2,000 0,01911214 0,10721444 ! axon guidance GO:0007411 99 66 2,000 0,01911214 0,10695357 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 0,01928056 0,10763417 GO:0045936|negative regulation of phosphate metabolic process, ! peptide transport GO:0015833 43 25 1,000 0,01928056 0,10737355 ! male gonad development GO:0008584 33 25 1,000 0,01928056 0,1071142 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01928056 0,10685609 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 1,000 0,01928056 0,10659922 ! leukocyte proliferation GO:0070661 39 25 1,000 0,01928056 0,10634359 GO:0032943|mononuclear cell proliferation, ! regulation of neuron differentiation GO:0045664 107 67 2,000 0,01988499 0,10941502 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 1,000 0,0207712 0,11401855 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 1,000 0,0207712 0,11374707 ! post-embryonic development GO:0009791 42 26 1,000 0,0207712 0,11347689 ! regulation of coagulation GO:0050818 39 26 1,000 0,0207712 0,11320799 ! respiratory gaseous exchange GO:0007585 47 27 1,000 0,02230834 0,12129828 ! lipid oxidation GO:0034440 38 27 1,000 0,02230834 0,1210122 GO:0019395|fatty acid oxidation, ! negative regulation of transcription regulator activity GO:0090048 47 27 1,000 0,02230834 0,12072747 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 1,000 0,02230834 0,12044407 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,02230834 0,120162 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,02314704 0,1243883 ! lymphocyte differentiation GO:0030098 113 71 2,000 0,02314704 0,12409835 ! triglyceride metabolic process GO:0006641 34 28 1,000 0,02389105 0,12778936 ! erythrocyte differentiation GO:0030218 38 28 1,000 0,02389105 0,12749286 ! response to organic cyclic substance GO:0014070 47 28 1,000 0,02389105 0,12719774 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,02389105 0,12690398 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,02389105 0,12661158 ! ensheathment of neurons GO:0007272 43 28 1,000 0,02389105 0,12632052 GO:0008366|axon ensheathment, ! myeloid leukocyte activation GO:0002274 39 28 1,000 0,02389105 0,12603079 ! positive regulation of catabolic process GO:0009896 40 28 1,000 0,02389105 0,12574239 ! placenta development GO:0001890 37 28 1,000 0,02389105 0,12545531 ! regulation of B cell activation GO:0050864 42 28 1,000 0,02389105 0,12516953 ! negative regulation of transport GO:0051051 116 73 2,000 0,0248805 0,13005714 ! cellular lipid catabolic process GO:0044242 105 73 2,000 0,0248805 0,12976223 ! response to hydrogen peroxide GO:0042542 42 29 1,000 0,02551847 0,13278844 ! ovulation cycle process GO:0022602 41 29 1,000 0,02551847 0,13248869 ! protein targeting to membrane GO:0006612 53 29 1,000 0,02551847 0,13219029 ! response to nutrient GO:0007584 104 75 2,000 0,02668217 0,13790787 ! spindle organization GO:0007051 37 30 1,000 0,02718972 0,14021605 ! ovulation cycle GO:0042698 43 30 1,000 0,02718972 0,13990237 ! hindbrain development GO:0030902 45 30 1,000 0,02718972 0,13959009 ! fatty acid catabolic process GO:0009062 43 30 1,000 0,02718972 0,1392792 ! gland development GO:0048732 148 77 2,000 0,02855195 0,14593217 ! one-carbon metabolic process GO:0006730 110 77 2,000 0,02855195 0,14560859 ! negative regulation of secretion GO:0051048 49 31 1,000 0,02890394 0,14707756 ! mammary gland development GO:0030879 57 31 1,000 0,02890394 0,14675288 ! glial cell differentiation GO:0010001 55 31 1,000 0,02890394 0,14642964 ! maintenance of protein location in cell GO:0032507 60 31 1,000 0,02890394 0,14610781 ! metanephros development GO:0001656 58 31 1,000 0,02890394 0,1457874 ! positive regulation of gene-specific transcription GO:0043193 47 31 1,000 0,02890394 0,14546839 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,02890394 0,14515078 ! leukocyte chemotaxis GO:0030595 43 31 1,000 0,02890394 0,14483454 GO:0060326|cell chemotaxis, ! T cell activation GO:0042110 134 79 2,000 0,03048962 0,1524481 ! mitotic sister chromatid segregation GO:0000070 45 32 1,000 0,03066027 0,15296881 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,03066027 0,15263771 ! meiosis I GO:0007127 52 32 1,000 0,03066027 0,15230804 ! neutral lipid metabolic process GO:0006638 41 32 1,000 0,03066027 0,15197979 GO:0006639|acylglycerol metabolic process, ! peripheral nervous system development GO:0007422 53 32 1,000 0,03066027 0,15165295 ! calcium-mediated signaling GO:0019722 50 32 1,000 0,03066027 0,15132752 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,03066027 0,15100347 ! protein localization in nucleus GO:0034504 133 80 2,000 0,03148385 0,15472831 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 1,000 0,03245788 0,15917512 ! negative regulation of cell adhesion GO:0007162 67 33 1,000 0,03245788 0,15883645 ! sister chromatid segregation GO:0000819 46 33 1,000 0,03245788 0,15849922 ! female gonad development GO:0008585 49 33 1,000 0,03245788 0,15816342 ! negative regulation of DNA binding GO:0043392 54 33 1,000 0,03245788 0,15782903 ! positive regulation of cell development GO:0010720 54 33 1,000 0,03245788 0,15749606 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,03245788 0,15716449 ! hormone biosynthetic process GO:0042446 45 33 1,000 0,03245788 0,15683431 ! cytokinesis GO:0000910 52 33 1,000 0,03245788 0,15650552 ! response to protein stimulus GO:0051789 111 81 2,000 0,03249495 0,15635646 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,03429595 0,16467783 ! development of primary male sexual characteristics GO:0046546 44 34 1,000 0,03429595 0,16433475 ! glycerol ether metabolic process GO:0006662 44 34 1,000 0,03429595 0,1639931 ! erythrocyte homeostasis GO:0034101 45 34 1,000 0,03429595 0,16365286 ! female gamete generation GO:0007292 43 34 1,000 0,03429595 0,16331404 ! dorsal/ventral pattern formation GO:0009953 44 34 1,000 0,03429595 0,16297661 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 0,03429595 0,16264058 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,03617365 0,17119216 ! cyclic nucleotide metabolic process GO:0009187 58 35 1,000 0,03617365 0,17084064 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,03617365 0,17049056 ! maintenance of protein location GO:0045185 65 35 1,000 0,03617365 0,1701419 ! glycogen metabolic process GO:0005977 48 35 1,000 0,03617365 0,16979468 ! pigment metabolic process GO:0042440 61 35 1,000 0,03617365 0,16944886 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 0,03670733 0,1715993 ! regulation of protein localization GO:0032880 132 85 2,000 0,03670733 0,17125123 ! regulation of hormone secretion GO:0046883 48 36 1,000 0,03809018 0,17734293 ! negative regulation of binding GO:0051100 58 36 1,000 0,03809018 0,17698467 ! organic ether metabolic process GO:0018904 46 36 1,000 0,03809018 0,17662784 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,03809018 0,17627245 GO:0046660|female sex differentiation, ! glucan metabolic process GO:0044042 49 36 1,000 0,03809018 0,17591849 GO:0006073|cellular glucan metabolic process, ! anatomical structure homeostasis GO:0060249 136 88 2,000 0,0400416 0,18456048 ! carboxylic acid catabolic process GO:0046395 122 88 2,000 0,0400416 0,18419136 GO:0016054|organic acid catabolic process, ! learning GO:0007612 67 37 1,000 0,04004474 0,18383814 ! regulation of T cell activation GO:0050863 128 89 2,000 0,04118606 0,18870106 ! gliogenesis GO:0042063 71 38 1,000 0,04203656 0,19221488 ! striated muscle cell differentiation GO:0051146 54 38 1,000 0,04203656 0,1918335 ! maintenance of location in cell GO:0051651 69 38 1,000 0,04203656 0,19145363 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,04217609 0,19170952 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,04217609 0,1913314 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,04217609 0,19095476 ! autophagic vacuole formation GO:0000045 8 5 0,000 0,04217609 0,1905796 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,04217609 0,19020592 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,04217609 0,18983369 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,04217609 0,18946293 ! sleep GO:0030431 11 5 0,000 0,04217609 0,1890936 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,04217609 0,18872572 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,04217609 0,18835926 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,04217609 0,18799422 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,04217609 0,1876306 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,04217609 0,18726837 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,04217609 0,18690755 ! tongue development GO:0043586 6 5 0,000 0,04217609 0,18654811 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,04217609 0,18619005 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,04217609 0,18583337 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,04217609 0,18547805 ! cobalt ion transport GO:0006824 9 5 0,000 0,04217609 0,18512408 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,04217609 0,18477146 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,04217609 0,18442019 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,04217609 0,18407024 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,04217609 0,18372162 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,04217609 0,18337432 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,04217609 0,18302834 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,04217609 0,18268365 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,04217609 0,18234026 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,04217609 0,18199816 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,04217609 0,18165734 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,04217609 0,18131779 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,04217609 0,18097951 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,04217609 0,18064249 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,04217609 0,18030672 ! malate metabolic process GO:0006108 7 5 0,000 0,04217609 0,1799722 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,04217609 0,17963892 ! behavioral response to pain GO:0048266 7 5 0,000 0,04217609 0,17930687 ! clathrin coat assembly GO:0048268 11 5 0,000 0,04217609 0,17897605 ! phototransduction, visible light GO:0007603 6 5 0,000 0,04217609 0,17864644 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,04217609 0,17831805 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,04217609 0,17799086 ! mating behavior GO:0007617 6 5 0,000 0,04217609 0,17766487 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,04217609 0,17734007 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,04217609 0,17701646 ! rhythmic behavior GO:0007622 12 5 0,000 0,04217609 0,17669402 ! copulation GO:0007620 7 5 0,000 0,04217609 0,17637276 ! glial cell fate commitment GO:0021781 12 5 0,000 0,04217609 0,17605266 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,04217609 0,17573373 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,04217609 0,17541595 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,04217609 0,17509931 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,04217609 0,17478382 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,04217609 0,17446946 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,04217609 0,17415623 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,04217609 0,17384412 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,04217609 0,17353313 ! response to protozoan GO:0001562 9 5 0,000 0,04217609 0,17322325 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,04217609 0,17291447 ! lymph vessel development GO:0001945 7 5 0,000 0,04217609 0,17260679 ! endochondral ossification GO:0001958 12 5 0,000 0,04217609 0,17230021 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,04217609 0,17199471 ! parathyroid gland development GO:0060017 8 5 0,000 0,04217609 0,1716903 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,04217609 0,17138696 ! anagen GO:0042640 6 5 0,000 0,04217609 0,17108469 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,04217609 0,17078348 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,04217609 0,17048334 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,04217609 0,17018424 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,04217609 0,1698862 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,04217609 0,16958919 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,04217609 0,16929322 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,04217609 0,16899829 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,04217609 0,16870438 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,04217609 0,16841149 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,04217609 0,16811961 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,04217609 0,16782875 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,04217609 0,16753889 ! ovulation GO:0030728 6 5 0,000 0,04217609 0,16725003 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,04217609 0,16696216 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,04217609 0,16667529 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,04217609 0,1663894 ! response to pH GO:0009268 9 5 0,000 0,04217609 0,16610448 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,04217609 0,16582054 ! proline biosynthetic process GO:0006561 6 5 0,000 0,04217609 0,16553757 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,04217609 0,16525557 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,04217609 0,16497452 ! polyol catabolic process GO:0046174 7 5 0,000 0,04217609 0,16469443 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,04217609 0,16441528 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,04217609 0,16413709 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,04217609 0,16385983 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,04217609 0,1635835 ! nerve growth factor processing GO:0032455 7 5 0,000 0,04217609 0,16330811 ! urea metabolic process GO:0019627 6 5 0,000 0,04217609 0,16303364 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,04217609 0,1627601 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,04217609 0,16248747 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,04217609 0,16221575 ! neutrophil activation GO:0042119 5 5 0,000 0,04217609 0,16194494 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,04217609 0,16167503 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,04217609 0,16140602 ! response to food GO:0032094 5 5 0,000 0,04217609 0,1611379 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,04217609 0,16087068 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,04217609 0,16060433 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,04217609 0,16033887 ! forebrain neuron development GO:0021884 7 5 0,000 0,04217609 0,16007429 ! melanosome organization GO:0032438 7 5 0,000 0,04217609 0,15981057 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,04217609 0,15954773 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,04217609 0,15928574 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,04217609 0,15902462 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,04217609 0,15876435 GO:0009251|glucan catabolic process, ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,04217609 0,15850493 ! nucleoside transport GO:0015858 6 5 0,000 0,04217609 0,15824636 ! nucleoside salvage GO:0043174 7 5 0,000 0,04217609 0,15798863 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,04217609 0,15773174 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,04217609 0,15747568 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,04217609 0,15722045 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,04217609 0,15696605 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,04217609 0,15671247 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,04217609 0,15645971 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,04217609 0,15620776 ! depyrimidination GO:0045008 8 5 0,000 0,04217609 0,15595662 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,04217609 0,15570629 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,04217609 0,15545676 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,04217609 0,15520803 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,04217609 0,15496009 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,04217609 0,15471295 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,04217609 0,15446659 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,04217609 0,15422101 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,04217609 0,15397622 ! monocyte differentiation GO:0030224 8 5 0,000 0,04217609 0,1537322 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,04217609 0,15348895 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,04217609 0,15324647 ! centrosome duplication GO:0051298 5 5 0,000 0,04217609 0,15300476 ! response to UV-C GO:0010225 6 5 0,000 0,04217609 0,15276381 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,04217609 0,15252361 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,04217609 0,15228417 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,04217609 0,15204548 ! regulation of dendrite development GO:0050773 12 5 0,000 0,04217609 0,15180754 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,04217609 0,15157034 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,04217609 0,15133388 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,04217609 0,15109816 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,04217609 0,15086317 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,04217609 0,15062891 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,04217609 0,15039538 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,04217609 0,15016257 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,04217609 0,14993048 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,04217609 0,1496991 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,04217609 0,14946844 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,04217609 0,14923849 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,04217609 0,14900924 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,04217609 0,1487807 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,04217609 0,14855286 ! neural tube patterning GO:0021532 6 5 0,000 0,04217609 0,14832572 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,04217609 0,14809926 ! histone demethylation GO:0016577 9 5 0,000 0,04217609 0,1478735 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,04217609 0,14764843 ! regulation of sterol transport GO:0032371 7 5 0,000 0,04217609 0,14742404 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,04217609 0,14720033 ! enteric nervous system development GO:0048484 8 5 0,000 0,04217609 0,1469773 ! establishment of planar polarity GO:0001736 6 5 0,000 0,04217609 0,14675494 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,04217609 0,14653326 ! muscle cell proliferation GO:0033002 8 5 0,000 0,04217609 0,14631224 ! transcription termination GO:0006353 8 5 0,000 0,04217609 0,14609189 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,04217609 0,14587221 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,04217609 0,14565318 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,04217609 0,14543481 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,04217609 0,14521709 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,04217609 0,14500003 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,04217609 0,14478361 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,04217609 0,14456784 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,04217609 0,1443527 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,04217609 0,14413821 ! apical protein localization GO:0045176 6 5 0,000 0,04217609 0,14392436 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,04217609 0,14371114 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,04217609 0,14349855 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,04217609 0,14328658 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,04217609 0,14307525 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,04217609 0,14286453 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,04217609 0,14265444 ! glial cell migration GO:0008347 10 5 0,000 0,04217609 0,14244496 ! determination of adult lifespan GO:0008340 8 5 0,000 0,04217609 0,1422361 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,04217609 0,14202784 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,04217609 0,1418202 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,04217609 0,14161316 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,04217609 0,14140673 ! neural plate development GO:0001840 6 5 0,000 0,04217609 0,1412009 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,04217609 0,14099567 ! regulation of sensory perception GO:0051931 6 5 0,000 0,04217609 0,14079103 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,04217609 0,14058698 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,04217609 0,14038353 GO:0046831|regulation of RNA export from nucleus, ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,04217609 0,14018066 ! sensory cilium assembly GO:0035058 6 5 0,000 0,04217609 0,13997838 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,04217609 0,13977668 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,04217609 0,13957557 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,04217609 0,13937503 ! spindle assembly GO:0051225 5 5 0,000 0,04217609 0,13917506 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,04217609 0,13897567 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,04217609 0,13877685 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,04217609 0,1385786 ! organ regeneration GO:0031100 7 5 0,000 0,04217609 0,13838091 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,04217609 0,13818379 ! carnitine metabolic process GO:0009437 5 5 0,000 0,04217609 0,13798722 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,04217609 0,13779122 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,04217609 0,13759577 GO:0055081|anion homeostasis, ! leukocyte differentiation GO:0002521 143 90 2,000 0,04234693 0,13795742 ! hormone metabolic process GO:0042445 121 90 2,000 0,04234693 0,13776229 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,04406485 0,14314853 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,04406485 0,14294662 ! male sex differentiation GO:0046661 53 39 1,000 0,04406485 0,14274529 ! developmental growth GO:0048589 62 39 1,000 0,04406485 0,14254452 ! synapse organization GO:0050808 55 39 1,000 0,04406485 0,14234432 ! cell fate commitment GO:0045165 141 92 2,000 0,04471765 0,1442505 ! response to calcium ion GO:0051592 58 40 1,000 0,04612886 0,14859436 ! regulation of tube size GO:0035150 60 40 1,000 0,04612886 0,14838653 GO:0050880|regulation of blood vessel size, ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,04612886 0,14817929 ! double-strand break repair GO:0006302 67 40 1,000 0,04612886 0,14797262 ! regulation of myeloid cell differentiation GO:0045637 69 40 1,000 0,04612886 0,14776653 ! energy reserve metabolic process GO:0006112 59 41 1,000 0,04822782 0,15427537 ! endosome transport GO:0016197 71 41 1,000 0,04822782 0,1540611 ! biopolymer methylation GO:0043414 62 41 1,000 0,04822782 0,15384743 ! regulation of JNK cascade GO:0046328 58 41 1,000 0,04822782 0,15363434 ! regulation of binding GO:0051098 151 95 2,000 0,04839512 0,15395404 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,05036101 0,15998663 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 1,000 0,05036101 0,15976595 ! excretion GO:0007588 63 42 1,000 0,05036101 0,15954589 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,05036101 0,15932643 ! tRNA transcription GO:0009304 11 6 0,000 0,05039682 0,15922072 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,05039682 0,15900231 GO:0045346|regulation of MHC class II biosynthetic process, ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,05039682 0,1587845 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,05039682 0,15856728 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,05039682 0,15835066 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,05039682 0,15813463 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,05039682 0,15791919 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,05039682 0,15770433 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,05039682 0,15749006 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,05039682 0,15727637 ! prostate gland development GO:0030850 9 6 0,000 0,05039682 0,15706325 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,05039682 0,15685072 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,05039682 0,15663876 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,05039682 0,15642737 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,05039682 0,15621655 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,05039682 0,1560063 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,05039682 0,15579662 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,05039682 0,15558749 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,05039682 0,15537893 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,05039682 0,15517093 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,05039682 0,15496348 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,05039682 0,15475658 ! signal peptide processing GO:0006465 8 6 0,000 0,05039682 0,15455024 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,05039682 0,15434445 ! mRNA stabilization GO:0048255 15 6 0,000 0,05039682 0,1541392 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,05039682 0,1539345 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,05039682 0,15373035 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,05039682 0,15352673 ! opsonization GO:0008228 8 6 0,000 0,05039682 0,15332365 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,05039682 0,15312111 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,05039682 0,15291911 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,05039682 0,15271763 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,05039682 0,15251669 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,05039682 0,15231627 ! photoreceptor cell development GO:0042461 10 6 0,000 0,05039682 0,15211638 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,05039682 0,15191701 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,05039682 0,15171817 ! mechanosensory behavior GO:0007638 8 6 0,000 0,05039682 0,15151985 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,05039682 0,15132204 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,05039682 0,15112475 ! response to interferon-gamma GO:0034341 12 6 0,000 0,05039682 0,15092797 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,05039682 0,15073171 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,05039682 0,15053595 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,05039682 0,1503407 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,05039682 0,15014596 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,05039682 0,14995172 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,05039682 0,14975799 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,05039682 0,14956475 ! thymic T cell selection GO:0045061 12 6 0,000 0,05039682 0,14937201 ! protein lipoylation GO:0009249 10 6 0,000 0,05039682 0,14917977 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,05039682 0,14898802 ! drug transport GO:0015893 6 6 0,000 0,05039682 0,14879677 ! cysteine metabolic process GO:0006534 7 6 0,000 0,05039682 0,148606 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,05039682 0,14841573 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,05039682 0,14822594 ! histidine metabolic process GO:0006547 6 6 0,000 0,05039682 0,14803663 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,05039682 0,14784781 ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,05039682 0,14765947 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,05039682 0,14747161 ! adenohypophysis development GO:0021984 10 6 0,000 0,05039682 0,14728422 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,05039682 0,14709731 ! hyperosmotic response GO:0006972 8 6 0,000 0,05039682 0,14691088 ! microtubule nucleation GO:0007020 10 6 0,000 0,05039682 0,14672491 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,05039682 0,14653942 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,05039682 0,1463544 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,05039682 0,14616984 ! response to dietary excess GO:0002021 7 6 0,000 0,05039682 0,14598575 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,05039682 0,14580212 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,05039682 0,14561895 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,05039682 0,14543624 ! purine salvage GO:0043101 8 6 0,000 0,05039682 0,14525399 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,05039682 0,14507219 ! neuron apoptosis GO:0051402 8 6 0,000 0,05039682 0,14489085 ! organic alcohol transport GO:0015850 9 6 0,000 0,05039682 0,14470996 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,05039682 0,14452953 ! T cell mediated immunity GO:0002456 12 6 0,000 0,05039682 0,14434954 ! male sex determination GO:0030238 9 6 0,000 0,05039682 0,14417 ! carnitine transport GO:0015879 8 6 0,000 0,05039682 0,14399091 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,05039682 0,14381226 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,05039682 0,14363405 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,05039682 0,14345629 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,05039682 0,14327896 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,05039682 0,14310208 ! parturition GO:0007567 12 6 0,000 0,05039682 0,14292563 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,05039682 0,14274961 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,05039682 0,14257402 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,05039682 0,14239887 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,05039682 0,14222415 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,05039682 0,14204986 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,05039682 0,14187599 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,05039682 0,14170255 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,05039682 0,14152953 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,05039682 0,14135693 ! macrophage differentiation GO:0030225 10 6 0,000 0,05039682 0,14118475 ! astrocyte development GO:0014002 14 6 0,000 0,05039682 0,141013 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,05039682 0,14084165 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,05039682 0,14067073 ! interaction with symbiont GO:0051702 8 6 0,000 0,05039682 0,14050022 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,05039682 0,14033012 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,05039682 0,14016044 ! eating behavior GO:0042755 6 6 0,000 0,05039682 0,13999116 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,05039682 0,13982229 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,05039682 0,13965383 ! response to copper ion GO:0046688 9 6 0,000 0,05039682 0,13948578 ! DNA topological change GO:0006265 8 6 0,000 0,05039682 0,13931813 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,05039682 0,13915088 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,05039682 0,13898403 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,05039682 0,13881758 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,05039682 0,13865153 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,05039682 0,13848588 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,05039682 0,13832062 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,05039682 0,13815576 ! gas homeostasis GO:0033483 11 6 0,000 0,05039682 0,13799129 ! hair follicle maturation GO:0048820 7 6 0,000 0,05039682 0,13782721 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,05039682 0,13766352 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,05039682 0,13750022 ! Schwann cell development GO:0014044 14 6 0,000 0,05039682 0,1373373 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,05039682 0,13717477 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,05039682 0,13701263 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,05039682 0,13685086 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,05039682 0,13668948 ! histone ubiquitination GO:0016574 7 6 0,000 0,05039682 0,13652848 ! regulation of meiosis GO:0040020 10 6 0,000 0,05039682 0,13636786 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,05039682 0,13620762 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,05039682 0,13604775 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,05039682 0,13588826 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,05039682 0,13572914 ! membrane to membrane docking GO:0022614 12 6 0,000 0,05039682 0,13557039 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,05039682 0,13541201 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,05039682 0,135254 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,05039682 0,13509637 ! receptor internalization GO:0031623 9 6 0,000 0,05039682 0,13493909 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,05039682 0,13478219 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,05039682 0,13462565 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,05039682 0,13446947 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,05039682 0,13431365 ! protein deubiquitination GO:0016579 8 6 0,000 0,05039682 0,1341582 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,05039682 0,1340031 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,05039682 0,13384836 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,05039682 0,13369398 ! thiamin metabolic process GO:0006772 6 6 0,000 0,05039682 0,13353996 ! midbrain development GO:0030901 6 6 0,000 0,05039682 0,13338629 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,05039682 0,13323297 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,05039682 0,13308 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,05039682 0,13292739 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,05039682 0,13277512 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,05039682 0,13262321 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,05039682 0,13247164 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,05039682 0,13232041 ! adult feeding behavior GO:0008343 6 6 0,000 0,05039682 0,13216953 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,05039682 0,132019 ! blastocyst growth GO:0001832 15 6 0,000 0,05039682 0,13186881 ! pigment granule transport GO:0051904 12 6 0,000 0,05039682 0,13171896 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,05039682 0,13156945 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,05039682 0,13142027 ! catecholamine transport GO:0051937 7 6 0,000 0,05039682 0,13127144 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,05039682 0,13112294 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,05039682 0,13097478 ! protein prenylation GO:0018342 10 6 0,000 0,05039682 0,13082695 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,05039682 0,13067946 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,05039682 0,1305323 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,05039682 0,13038547 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,05039682 0,13023897 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,05039682 0,1300928 ! regulation of gene-specific transcription GO:0032583 69 43 1,000 0,05252768 0,13544132 ! leukocyte migration GO:0050900 60 43 1,000 0,05252768 0,13528965 ! vesicle organization GO:0016050 79 43 1,000 0,05252768 0,13513832 ! response to insulin stimulus GO:0032868 63 43 1,000 0,05252768 0,13498732 ! epithelial tube morphogenesis GO:0060562 65 43 1,000 0,05252768 0,13483667 ! methylation GO:0032259 64 43 1,000 0,05252768 0,13468635 ! protein import GO:0017038 156 99 2,000 0,05352175 0,13708244 ! regulation of action potential GO:0001508 71 44 1,000 0,05472711 0,14001373 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,05472711 0,13985816 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 1,000 0,05472711 0,13970294 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,05472711 0,13954805 ! homophilic cell adhesion GO:0007156 149 100 2,000 0,05484274 0,13968805 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,05695859 0,14491675 ! cell recognition GO:0008037 58 45 1,000 0,05695859 0,14475663 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,05854745 0,1486304 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,05854745 0,14846653 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,05854745 0,14830302 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,05854745 0,14813987 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,05854745 0,14797708 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,05854745 0,14781464 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,05854745 0,14765257 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,05854745 0,14749084 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,05854745 0,14732947 ! reproductive behavior GO:0019098 12 7 0,000 0,05854745 0,14716846 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,05854745 0,14700779 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,05854745 0,14684748 ! oligopeptide transport GO:0006857 11 7 0,000 0,05854745 0,14668752 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,05854745 0,1465279 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,05854745 0,14636863 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,05854745 0,14620971 ! RNA methylation GO:0001510 11 7 0,000 0,05854745 0,14605113 ! pericardium development GO:0060039 8 7 0,000 0,05854745 0,14589289 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,05854745 0,145735 ! fibril organization GO:0043206 13 7 0,000 0,05854745 0,14557745 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,05854745 0,14542024 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,05854745 0,14526337 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,05854745 0,14510683 ! lipoprotein transport GO:0042953 9 7 0,000 0,05854745 0,14495063 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,05854745 0,14479477 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,05854745 0,14463925 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,05854745 0,14448406 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,05854745 0,1443292 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,05854745 0,14417467 ! chemosensory behavior GO:0007635 9 7 0,000 0,05854745 0,14402047 ! microtubule bundle formation GO:0001578 8 7 0,000 0,05854745 0,1438666 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,05854745 0,14371306 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,05854745 0,14355985 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,05854745 0,14340696 ! leukocyte degranulation GO:0043299 10 7 0,000 0,05854745 0,1432544 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,05854745 0,14310217 ! reflex GO:0060004 12 7 0,000 0,05854745 0,14295025 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,05854745 0,14279866 GO:0045911|positive regulation of DNA recombination, ! protein-cofactor linkage GO:0018065 13 7 0,000 0,05854745 0,14264739 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,05854745 0,14249644 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,05854745 0,14234581 ! spinal cord patterning GO:0021511 7 7 0,000 0,05854745 0,1421955 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,05854745 0,14204551 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,05854745 0,14189583 ! adrenal gland development GO:0030325 17 7 0,000 0,05854745 0,14174646 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,05854745 0,14159741 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,05854745 0,14144868 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,05854745 0,14130025 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,05854745 0,14115214 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,05854745 0,14100433 ! endosome organization GO:0007032 10 7 0,000 0,05854745 0,14085684 ! thyroid hormone generation GO:0006590 11 7 0,000 0,05854745 0,14070965 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,05854745 0,14056278 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,05854745 0,1404162 ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,05854745 0,14026994 ! galactose metabolic process GO:0006012 10 7 0,000 0,05854745 0,14012397 ! vesicle fusion GO:0006906 15 7 0,000 0,05854745 0,13997832 ! intracellular pH reduction GO:0051452 10 7 0,000 0,05854745 0,13983296 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,05854745 0,1396879 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,05854745 0,13954315 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,05854745 0,1393987 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,05854745 0,13925454 ! retinol metabolic process GO:0042572 9 7 0,000 0,05854745 0,13911068 ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,05854745 0,13896712 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,05854745 0,13882386 ! rRNA modification GO:0000154 12 7 0,000 0,05854745 0,13868089 ! protein heterooligomerization GO:0051291 10 7 0,000 0,05854745 0,13853821 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,05854745 0,13839583 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,05854745 0,13825374 ! intermediate filament organization GO:0045109 11 7 0,000 0,05854745 0,13811194 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,05854745 0,13797043 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,05854745 0,13782921 ! fibrinolysis GO:0042730 9 7 0,000 0,05854745 0,13768828 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,05854745 0,13754764 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,05854745 0,13740729 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,05854745 0,13726722 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,05854745 0,13712743 ! response to tropane GO:0014073 13 7 0,000 0,05854745 0,13698793 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,05854745 0,13684872 ! melanosome localization GO:0032400 10 7 0,000 0,05854745 0,13670979 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,05854745 0,13657114 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,05854745 0,13643277 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,05854745 0,13629468 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,05854745 0,13615687 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,05854745 0,13601933 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,05854745 0,13588208 ! multicellular organismal aging GO:0010259 11 7 0,000 0,05854745 0,1357451 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,05854745 0,1356084 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,05854745 0,13547197 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,05854745 0,13533582 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,05854745 0,13519994 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,05854745 0,13506433 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,05854745 0,134929 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,05854745 0,13479393 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,05854745 0,13465914 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,05854745 0,13452462 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,05854745 0,13439036 ! regulation of lipid transport GO:0032368 13 7 0,000 0,05854745 0,13425637 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,05854745 0,13412265 ! neuroblast proliferation GO:0007405 13 7 0,000 0,05854745 0,13398919 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,05854745 0,133856 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,05854745 0,13372308 ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,05854745 0,13359042 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,05854745 0,13345802 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,05854745 0,13332588 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,05854745 0,13319401 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,05854745 0,13306239 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,05854745 0,13293104 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,05854745 0,13279994 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,05854745 0,1326691 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,05854745 0,13253852 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,05854745 0,1324082 ! lymph node development GO:0048535 9 7 0,000 0,05854745 0,13227813 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,05854745 0,13214832 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,05854745 0,13201876 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,05854745 0,13188946 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,05854745 0,13176041 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,05854745 0,13163161 ! ATP catabolic process GO:0006200 10 7 0,000 0,05854745 0,13150307 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,05854745 0,13137477 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,05854745 0,13124672 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,05854745 0,13111893 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,05854745 0,13099138 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,05854745 0,13086408 ! muscle adaptation GO:0043500 12 7 0,000 0,05854745 0,13073703 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,05854745 0,13061022 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,05854745 0,13048366 ! retina homeostasis GO:0001895 9 7 0,000 0,05854745 0,13035735 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,05854745 0,13023128 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,05854745 0,13010545 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,05854745 0,12997986 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,05854745 0,12985452 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,05854745 0,12972942 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,05854745 0,12960456 ! regulation of ossification GO:0030278 71 46 1,000 0,05922141 0,13097042 ! response to estrogen stimulus GO:0043627 74 47 1,000 0,06151488 0,13591185 ! regulation of muscle contraction GO:0006937 69 48 1,000 0,06383832 0,14090993 ! cellular polysaccharide metabolic process GO:0044264 63 48 1,000 0,06383832 0,14077483 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 1,000 0,06619106 0,14582321 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,06619106 0,14568367 ! germ cell development GO:0007281 68 49 1,000 0,06619106 0,14554439 ! cartilage development GO:0051216 70 49 1,000 0,06619106 0,14540538 ! maintenance of location GO:0051235 84 49 1,000 0,06619106 0,14526663 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,06662859 0,14608747 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,06662859 0,14594834 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,06662859 0,14580947 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,06662859 0,14567087 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,06662859 0,14553253 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,06662859 0,14539446 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,06662859 0,14525664 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,06662859 0,14511909 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,06662859 0,14498179 ! phosphate transport GO:0006817 10 8 0,000 0,06662859 0,14484476 ! N-glycan processing GO:0006491 12 8 0,000 0,06662859 0,14470799 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,06662859 0,14457147 ! UTP metabolic process GO:0046051 8 8 0,000 0,06662859 0,14443521 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,06662859 0,14429921 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,06662859 0,14416346 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,06662859 0,14402797 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,06662859 0,14389273 ! succinate metabolic process GO:0006105 14 8 0,000 0,06662859 0,14375775 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,06662859 0,14362301 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,06662859 0,14348854 ! keratinocyte proliferation GO:0043616 12 8 0,000 0,06662859 0,14335431 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,06662859 0,14322033 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,06662859 0,14308661 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,06662859 0,14295313 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,06662859 0,1428199 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,06662859 0,14268692 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,06662859 0,14255419 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,06662859 0,14242171 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,06662859 0,14228947 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,06662859 0,14215747 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,06662859 0,14202572 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,06662859 0,14189422 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,06662859 0,14176296 ! astrocyte differentiation GO:0048708 16 8 0,000 0,06662859 0,14163194 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,06662859 0,14150116 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,06662859 0,14137062 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,06662859 0,14124033 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,06662859 0,14111027 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,06662859 0,14098046 ! macrophage activation GO:0042116 12 8 0,000 0,06662859 0,14085088 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,06662859 0,14072154 ! multicellular organism growth GO:0035264 14 8 0,000 0,06662859 0,14059244 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,06662859 0,14046357 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,06662859 0,14033494 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,06662859 0,14020655 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,06662859 0,14007839 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,06662859 0,13995046 ! ruffle organization GO:0031529 11 8 0,000 0,06662859 0,13982277 ! osteoblast development GO:0002076 13 8 0,000 0,06662859 0,13969531 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,06662859 0,13956808 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,06662859 0,13944109 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,06662859 0,13931432 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,06662859 0,13918779 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,06662859 0,13906149 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,06662859 0,13893541 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,06662859 0,13880956 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,06662859 0,13868394 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,06662859 0,13855855 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,06662859 0,13843338 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,06662859 0,13830844 ! segment specification GO:0007379 10 8 0,000 0,06662859 0,13818373 ! cellular extravasation GO:0045123 11 8 0,000 0,06662859 0,13805924 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,06662859 0,13793497 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,06662859 0,13781093 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,06662859 0,13768711 ! snRNA metabolic process GO:0016073 10 8 0,000 0,06662859 0,13756352 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,06662859 0,13744014 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,06662859 0,13731699 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,06662859 0,13719405 ! nucleosome disassembly GO:0006337 12 8 0,000 0,06662859 0,13707134 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,06662859 0,13694884 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,06662859 0,13682657 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,06662859 0,13670451 ! icosanoid secretion GO:0032309 12 8 0,000 0,06662859 0,13658267 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,06662859 0,13646105 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,06662859 0,13633964 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,06662859 0,13621845 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,06662859 0,13609747 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,06662859 0,13597671 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,06662859 0,13585617 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,06662859 0,13573583 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,06662859 0,13561571 ! sterol catabolic process GO:0016127 9 8 0,000 0,06662859 0,13549581 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,06662859 0,13537611 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,06662859 0,13525663 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,06662859 0,13513735 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,06662859 0,13501829 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,06662859 0,13489943 ! prophase GO:0051324 11 8 0,000 0,06662859 0,13478079 ! S phase GO:0051320 8 8 0,000 0,06662859 0,13466235 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,06662859 0,13454412 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,06662859 0,1344261 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,06662859 0,13430829 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,06662859 0,13419068 ! hormone catabolic process GO:0042447 13 8 0,000 0,06662859 0,13407328 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,06662859 0,13395608 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,06662859 0,13383909 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,06662859 0,1337223 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,06662859 0,13360572 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,06662859 0,13348934 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,06662859 0,13337316 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,06662859 0,13325718 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,06662859 0,1331414 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,06662859 0,13302583 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,06662859 0,13291046 ! lamellipodium assembly GO:0030032 9 8 0,000 0,06662859 0,13279528 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,06662859 0,13268031 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,06662859 0,13256553 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,06662859 0,13245096 ! lipid modification GO:0030258 73 50 1,000 0,06857241 0,13619737 ! positive regulation of growth GO:0045927 67 50 1,000 0,06857241 0,13607985 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,06857241 0,13596254 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,06857241 0,13584544 ! positive regulation of secretion GO:0051047 71 51 1,000 0,07098174 0,14049742 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,07098174 0,14037661 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,07098174 0,14025601 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,07098174 0,14013562 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,07098174 0,14001544 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,07341839 0,14469776 ! nucleotide-excision repair GO:0006289 64 52 1,000 0,07341839 0,14457388 ! establishment of organelle localization GO:0051656 85 52 1,000 0,07341839 0,1444502 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,07464082 0,14672982 ! regulation of developmental growth GO:0048638 13 9 0,000 0,07464082 0,14660451 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,07464082 0,14647943 ! telencephalon cell migration GO:0022029 16 9 0,000 0,07464082 0,14635455 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,07464082 0,14622989 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,07464082 0,14610544 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,07464082 0,1459812 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,07464082 0,14585717 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,07464082 0,14573335 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,07464082 0,14560974 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,07464082 0,14548634 ! GTP metabolic process GO:0046039 9 9 0,000 0,07464082 0,14536316 ! elastic fiber assembly GO:0048251 13 9 0,000 0,07464082 0,14524017 ! social behavior GO:0035176 14 9 0,000 0,07464082 0,1451174 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,07464082 0,14499484 ! artery development GO:0060840 19 9 0,000 0,07464082 0,14487248 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,07464082 0,14475033 ! regulation of glycolysis GO:0006110 15 9 0,000 0,07464082 0,14462838 ! response to pain GO:0048265 16 9 0,000 0,07464082 0,14450664 ! protein complex disassembly GO:0043241 17 9 0,000 0,07464082 0,1443851 GO:0043624|cellular protein complex disassembly, ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,07464082 0,14426377 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,07464082 0,14414264 ! lung alveolus development GO:0048286 17 9 0,000 0,07464082 0,14402172 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,07464082 0,14390099 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,07464082 0,14378047 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,07464082 0,14366016 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,07464082 0,14354004 ! ventral spinal cord development GO:0021517 11 9 0,000 0,07464082 0,14342012 ! protein targeting to ER GO:0045047 19 9 0,000 0,07464082 0,14330041 ! endoderm development GO:0007492 12 9 0,000 0,07464082 0,14318089 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,07464082 0,14306157 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,07464082 0,14294245 ! arginine catabolic process GO:0006527 10 9 0,000 0,07464082 0,14282353 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,07464082 0,14270481 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,07464082 0,14258628 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,07464082 0,14246796 ! phosphagen metabolic process GO:0006599 12 9 0,000 0,07464082 0,14234982 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,07464082 0,14223189 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,07464082 0,14211414 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,07464082 0,1419966 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,07464082 0,14187924 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,07464082 0,14176209 ! mannose metabolic process GO:0006013 9 9 0,000 0,07464082 0,14164512 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,07464082 0,14152835 ! receptor clustering GO:0043113 15 9 0,000 0,07464082 0,14141177 ! epithelial cell development GO:0002064 10 9 0,000 0,07464082 0,14129538 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,07464082 0,14117918 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,07464082 0,14106318 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,07464082 0,14094736 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,07464082 0,14083174 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,07464082 0,1407163 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,07464082 0,14060105 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,07464082 0,140486 ! blastoderm segmentation GO:0007350 11 9 0,000 0,07464082 0,14037113 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,07464082 0,14025644 ! DNA ligation GO:0006266 14 9 0,000 0,07464082 0,14014195 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,07464082 0,14002764 ! response to amine stimulus GO:0014075 13 9 0,000 0,07464082 0,13991352 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,07464082 0,13979958 ! erythrocyte development GO:0048821 11 9 0,000 0,07464082 0,13968583 ! mRNA cleavage GO:0006379 13 9 0,000 0,07464082 0,13957227 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,07464082 0,13945888 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,07464082 0,13934569 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,07464082 0,13923267 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,07464082 0,13911984 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,07464082 0,1390072 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,07464082 0,13889473 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,07464082 0,13878245 ! acid secretion GO:0046717 14 9 0,000 0,07464082 0,13867034 ! musculoskeletal movement GO:0050881 11 9 0,000 0,07464082 0,13855842 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,07464082 0,13844668 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,07464082 0,13833512 ! purine base metabolic process GO:0006144 18 9 0,000 0,07464082 0,13822374 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,07464082 0,13811254 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,07464082 0,13800152 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,07464082 0,13789067 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,07464082 0,13778 ! detection of calcium ion GO:0005513 13 9 0,000 0,07464082 0,13766952 ! pyrimidine base metabolic process GO:0006206 14 9 0,000 0,07464082 0,1375592 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,07464082 0,13744907 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,07464082 0,13733911 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of amino acid transport GO:0051955 11 9 0,000 0,07464082 0,13722933 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,07464082 0,13711972 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,07464082 0,13701028 ! prepulse inhibition GO:0060134 14 9 0,000 0,07464082 0,13690103 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,07464082 0,13679194 ! insulin secretion GO:0030073 17 9 0,000 0,07464082 0,13668303 ! sequestering of metal ion GO:0051238 11 9 0,000 0,07464082 0,13657429 ! establishment of cell polarity GO:0030010 12 9 0,000 0,07464082 0,13646573 ! nucleus localization GO:0051647 15 9 0,000 0,07464082 0,13635734 ! regulation of synapse organization GO:0050807 12 9 0,000 0,07464082 0,13624912 ! localization within membrane GO:0051668 15 9 0,000 0,07464082 0,13614107 ! regulation of bone remodeling GO:0046850 90 53 1,000 0,07588171 0,13829473 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,07588171 0,13818523 ! kidney development GO:0001822 90 53 1,000 0,07588171 0,1380759 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,07837109 0,1424929 ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,07837109 0,14238035 ! detection of external stimulus GO:0009581 66 54 1,000 0,07837109 0,14226797 ! regulation of tissue remodeling GO:0034103 91 54 1,000 0,07837109 0,14215577 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,07837109 0,14204375 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,07837109 0,1419319 ! negative regulation of muscle development GO:0048635 12 10 0,000 0,08258473 0,14944522 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,08258473 0,14932773 ! neuron fate specification GO:0048665 11 10 0,000 0,08258473 0,14921042 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,08258473 0,14909331 ! thyroid gland development GO:0030878 19 10 0,000 0,08258473 0,14897637 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,08258473 0,14885962 ! synapsis GO:0007129 13 10 0,000 0,08258473 0,14874305 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,08258473 0,14862666 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,08258473 0,14851045 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,08258473 0,14839443 GO:0007520|myoblast fusion, ! sulfate transport GO:0008272 12 10 0,000 0,08258473 0,14827859 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,08258473 0,14816293 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,08258473 0,14804744 ! androgen metabolic process GO:0008209 13 10 0,000 0,08258473 0,14793214 ! phospholipid efflux GO:0033700 16 10 0,000 0,08258473 0,14781702 ! hippocampus development GO:0021766 19 10 0,000 0,08258473 0,14770208 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,08258473 0,14758731 ! blood vessel remodeling GO:0001974 21 10 0,000 0,08258473 0,14747273 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,08258473 0,14735832 ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,08258473 0,14724409 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,08258473 0,14713003 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,08258473 0,14701615 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,08258473 0,14690245 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,08258473 0,14678893 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,08258473 0,14667558 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,08258473 0,1465624 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,08258473 0,1464494 ! melanocyte differentiation GO:0030318 15 10 0,000 0,08258473 0,14633657 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,08258473 0,14622392 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,08258473 0,14611144 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,08258473 0,14599913 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,08258473 0,145887 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,08258473 0,14577504 ! forebrain cell migration GO:0021885 17 10 0,000 0,08258473 0,14566324 ! lipid digestion GO:0044241 15 10 0,000 0,08258473 0,14555163 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,08258473 0,14544018 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,08258473 0,1453289 ! UV protection GO:0009650 14 10 0,000 0,08258473 0,14521779 ! entry into host cell GO:0030260 20 10 0,000 0,08258473 0,14510685 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,08258473 0,14499608 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,08258473 0,14488549 ! regulation of bone resorption GO:0045124 24 10 0,000 0,08258473 0,14477505 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,08258473 0,14466479 ! regulation of organ growth GO:0046620 11 10 0,000 0,08258473 0,1445547 ! response to dsRNA GO:0043331 18 10 0,000 0,08258473 0,14444477 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,08258473 0,14433501 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,08258473 0,14422541 ! embryonic axis specification GO:0000578 12 10 0,000 0,08258473 0,14411599 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,08258473 0,14400673 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,08258473 0,14389763 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,08258473 0,1437887 ! cranial nerve development GO:0021545 12 10 0,000 0,08258473 0,14367993 ! fucose catabolic process GO:0019317 16 10 0,000 0,08258473 0,14357133 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,08258473 0,14346289 ! protein sumoylation GO:0016925 12 10 0,000 0,08258473 0,14335462 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,08258473 0,14324651 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,08258473 0,14313856 ! zymogen activation GO:0031638 14 10 0,000 0,08258473 0,14303078 ! salivary gland development GO:0007431 22 10 0,000 0,08258473 0,14292315 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,08258473 0,14281569 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,08258473 0,14270839 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,08258473 0,14260125 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,08258473 0,14249428 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,08258473 0,14238746 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,08258473 0,1422808 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,08258473 0,1421743 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,08258473 0,14206797 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,08258473 0,14196179 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,08258473 0,14185577 ! detection of bacterium GO:0016045 10 10 0,000 0,08258473 0,1417499 ! embryonic gut development GO:0048566 11 10 0,000 0,08258473 0,1416442 ! activation of innate immune response GO:0002218 10 10 0,000 0,08258473 0,14153865 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,08258473 0,14143326 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,08258473 0,14132803 ! developmental induction GO:0031128 13 10 0,000 0,08258473 0,14122295 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,08258473 0,14111803 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,08258473 0,14101327 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,08258473 0,14090866 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,08258473 0,1408042 ! regulation of lipid metabolic process GO:0019216 84 56 1,000 0,08342553 0,14213239 ! chromosome segregation GO:0007059 83 57 1,000 0,08598938 0,14639198 ! secondary metabolic process GO:0019748 84 57 1,000 0,08598938 0,1462837 ! gonad development GO:0008406 79 57 1,000 0,08598938 0,14617558 ! rRNA transcription GO:0009303 17 11 0,000 0,09046089 0,15366325 ! respiratory burst GO:0045730 14 11 0,000 0,09046089 0,15354985 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,09046089 0,15343661 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,09046089 0,15332354 ! virus-host interaction GO:0019048 17 11 0,000 0,09046089 0,15321063 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,09046089 0,1530979 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,09046089 0,15298533 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,09046089 0,15287292 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,09046089 0,15276068 ! RNA polyadenylation GO:0043631 19 11 0,000 0,09046089 0,1526486 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,09046089 0,15253669 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,09046089 0,15242494 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,09046089 0,15231335 ! T cell proliferation GO:0042098 20 11 0,000 0,09046089 0,15220193 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,09046089 0,15209067 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,09046089 0,15197958 ! bone resorption GO:0045453 16 11 0,000 0,09046089 0,15186864 ! regulated secretory pathway GO:0045055 14 11 0,000 0,09046089 0,15175787 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,09046089 0,15164726 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,09046089 0,15153681 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,09046089 0,15142652 ! syncytium formation GO:0006949 15 11 0,000 0,09046089 0,15131639 ! plasma membrane organization GO:0007009 18 11 0,000 0,09046089 0,15120643 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,09046089 0,15109662 ! mitotic spindle organization GO:0007052 15 11 0,000 0,09046089 0,15098697 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,09046089 0,15087748 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,09046089 0,15076815 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,09046089 0,15065897 ! adult heart development GO:0007512 11 11 0,000 0,09046089 0,15054996 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,09046089 0,1504411 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,09046089 0,1503324 ! temperature homeostasis GO:0001659 16 11 0,000 0,09046089 0,15022386 ! L-glutamate transport GO:0015813 16 11 0,000 0,09046089 0,15011547 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,09046089 0,15000724 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,09046089 0,14989917 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,09046089 0,14979125 ! stem cell development GO:0048864 29 11 0,000 0,09046089 0,14968348 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,09046089 0,14957587 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,09046089 0,14946842 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,09046089 0,14936112 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,09046089 0,14925398 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,09046089 0,14914698 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,09046089 0,14904014 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,09046089 0,14893346 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,09046089 0,14882693 ! ribosome assembly GO:0042255 13 11 0,000 0,09046089 0,14872054 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,09046089 0,14861432 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,09046089 0,14850824 ! chromatin silencing GO:0006342 19 11 0,000 0,09046089 0,14840231 ! nucleosome positioning GO:0016584 13 11 0,000 0,09046089 0,14829654 ! regulation of isotype switching GO:0045191 19 11 0,000 0,09046089 0,14819091 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,09046089 0,14808544 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,09046089 0,14798012 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,09046089 0,14787494 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,09046089 0,14776992 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,09046089 0,14766504 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,09046089 0,14756031 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,09046089 0,14745573 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,09046089 0,1473513 ! male genitalia development GO:0030539 13 11 0,000 0,09046089 0,14724702 ! cholesterol efflux GO:0033344 19 11 0,000 0,09046089 0,14714289 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,09046089 0,1470389 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,09046089 0,14693506 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,09046089 0,14683136 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,09046089 0,14672782 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,09046089 0,14662441 ! defense response to fungus GO:0050832 12 11 0,000 0,09046089 0,14652116 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,09046089 0,14641805 ! lysogeny GO:0030069 18 11 0,000 0,09046089 0,14631508 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,09046089 0,14621226 ! acrosome reaction GO:0007340 13 11 0,000 0,09046089 0,14610958 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,09046089 0,14600705 ! lung development GO:0030324 94 59 1,000 0,09118733 0,14707634 ! nucleoside monophosphate metabolic process GO:0009123 95 59 1,000 0,09118733 0,14697327 ! myeloid cell differentiation GO:0030099 85 59 1,000 0,09118733 0,14687035 ! regulation of heart contraction GO:0008016 91 60 1,000 0,09382027 0,15100533 ! regulation of cellular response to stress GO:0080135 85 61 1,000 0,09647509 0,15516973 ! meiosis GO:0007126 96 61 1,000 0,09647509 0,15506129 GO:0051327|M phase of meiotic cell cycle, ! urogenital system development GO:0001655 101 61 1,000 0,09647509 0,15495301 ! lactation GO:0007595 20 12 0,000 0,09826988 0,15772555 ! reproductive cellular process GO:0048610 14 12 0,000 0,09826988 0,15761556 ! tRNA modification GO:0006400 14 12 0,000 0,09826988 0,15750573 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,09826988 0,15739604 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,09826988 0,15728651 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,09826988 0,15717713 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,09826988 0,15706791 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,09826988 0,15695883 ! non-recombinational repair GO:0000726 19 12 0,000 0,09826988 0,15684991 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,09826988 0,15674114 ! peroxisomal transport GO:0043574 21 12 0,000 0,09826988 0,15663252 ! cartilage condensation GO:0001502 18 12 0,000 0,09826988 0,15652404 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,09826988 0,15641572 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,09826988 0,15630755 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,09826988 0,15619953 ! heart looping GO:0001947 15 12 0,000 0,09826988 0,15609166 ! palate development GO:0060021 15 12 0,000 0,09826988 0,15598393 ! positive regulation of cell growth GO:0030307 16 12 0,000 0,09826988 0,15587636 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,09826988 0,15576893 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,09826988 0,15566165 ! arginine metabolic process GO:0006525 13 12 0,000 0,09826988 0,15555452 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,09826988 0,15544754 ! methionine metabolic process GO:0006555 13 12 0,000 0,09826988 0,1553407 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,09826988 0,15523401 ! Golgi organization GO:0007030 18 12 0,000 0,09826988 0,15512747 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,09826988 0,15502107 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,09826988 0,15491482 ! monoamine transport GO:0015844 13 12 0,000 0,09826988 0,15480871 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,09826988 0,15470275 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,09826988 0,15459694 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,09826988 0,15449126 ! L-amino acid transport GO:0015807 20 12 0,000 0,09826988 0,15438574 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,09826988 0,15428035 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,09826988 0,15417512 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,09826988 0,15407002 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,09826988 0,15396507 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,09826988 0,15386026 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,09826988 0,15375559 ! cerebellum development GO:0021549 13 12 0,000 0,09826988 0,15365107 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,09826988 0,15354668 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,09826988 0,15344244 ! histone acetylation GO:0016573 23 12 0,000 0,09826988 0,15333834 ! histone methylation GO:0016571 15 12 0,000 0,09826988 0,15323439 ! autonomic nervous system development GO:0048483 23 12 0,000 0,09826988 0,15313057 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,09826988 0,15302689 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,09826988 0,15292336 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,09826988 0,15281996 ! regulation of epidermis development GO:0045682 17 12 0,000 0,09826988 0,1527167 ! intestinal absorption GO:0050892 19 12 0,000 0,09826988 0,15261359 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,09826988 0,15251061 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,09826988 0,15240777 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,09826988 0,15230507 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,09826988 0,1522025 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,09826988 0,15210008 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,09826988 0,15199779 ! microspike assembly GO:0030035 23 12 0,000 0,09826988 0,15189564 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,09826988 0,15179363 ! response to cold GO:0009409 14 12 0,000 0,09826988 0,15169176 ! amine catabolic process GO:0009310 90 62 1,000 0,09915123 0,15294959 ! respiratory tube development GO:0030323 99 62 1,000 0,09915123 0,15284707 ! meiotic cell cycle GO:0051321 97 62 1,000 0,09915123 0,1527447 ! organelle localization GO:0051640 96 62 1,000 0,09915123 0,15264246 ! regulation of transcription factor activity GO:0051090 97 63 1,000 0,10184813 0,15668943 GO:0090046|regulation of transcription regulator activity, ! regulation of lipase activity GO:0060191 109 63 1,000 0,10184813 0,1565847 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,10456525 0,16065469 ! respiratory system development GO:0060541 100 64 1,000 0,10456525 0,16054744 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,10601227 0,16266058 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,10601227 0,16255214 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,10601227 0,16244385 ! cGMP metabolic process GO:0046068 16 13 0,000 0,10601227 0,16233569 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,10601227 0,16222769 ! water transport GO:0006833 17 13 0,000 0,10601227 0,16211982 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,10601227 0,1620121 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,10601227 0,16190452 ! lipid localization GO:0010876 24 13 0,000 0,10601227 0,16179709 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,10601227 0,1616898 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,10601227 0,16158265 ! organelle fusion GO:0048284 28 13 0,000 0,10601227 0,16147564 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,10601227 0,16136877 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,10601227 0,16126204 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,10601227 0,16115546 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,10601227 0,16104902 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,10601227 0,16094271 ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,10601227 0,16083655 ! glutamate metabolic process GO:0006536 18 13 0,000 0,10601227 0,16073053 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,10601227 0,16062465 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,10601227 0,1605189 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,10601227 0,1604133 ! NAD metabolic process GO:0019674 21 13 0,000 0,10601227 0,16030783 ! exocrine system development GO:0035272 27 13 0,000 0,10601227 0,1602025 ! regulation of exocytosis GO:0017157 17 13 0,000 0,10601227 0,16009732 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,10601227 0,15999226 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,10601227 0,15988735 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,10601227 0,15978258 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,10601227 0,15967794 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,10601227 0,15957344 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,10601227 0,15946907 ! genitalia development GO:0048806 15 13 0,000 0,10601227 0,15936484 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,10601227 0,15926075 ! tissue regeneration GO:0042246 21 13 0,000 0,10601227 0,1591568 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,10601227 0,15905298 ! cofactor transport GO:0051181 19 13 0,000 0,10601227 0,15894929 ! NADP metabolic process GO:0006739 18 13 0,000 0,10601227 0,15884574 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,10601227 0,15874233 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,10601227 0,15863904 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,10601227 0,1585359 ! gas transport GO:0015669 18 13 0,000 0,10601227 0,15843289 ! regulation of RNA stability GO:0043487 28 13 0,000 0,10601227 0,15833001 ! heme biosynthetic process GO:0006783 20 13 0,000 0,10601227 0,15822726 ! regulation of axon extension GO:0030516 23 13 0,000 0,10601227 0,15812465 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,10601227 0,15802217 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,10601227 0,15791983 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,10601227 0,15781761 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,10601227 0,15771553 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,10601227 0,15761358 ! reproductive structure development GO:0048608 90 65 1,000 0,10730204 0,1594281 ! regulation of MAPKKK cascade GO:0043408 101 65 1,000 0,10730204 0,15932517 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,11005797 0,16331183 ! regulation of Rho protein signal transduction GO:0035023 111 66 1,000 0,11005797 0,16320654 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 1,000 0,11283253 0,16721315 ! superoxide anion generation GO:0042554 18 14 0,000 0,11368862 0,16837335 ! neuron maturation GO:0042551 21 14 0,000 0,11368862 0,168265 ! regulation of S phase GO:0033261 18 14 0,000 0,11368862 0,1681568 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,11368862 0,16804873 ! myotube differentiation GO:0014902 21 14 0,000 0,11368862 0,16794079 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,11368862 0,167833 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,11368862 0,16772535 ! inositol metabolic process GO:0006020 20 14 0,000 0,11368862 0,16761783 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,11368862 0,16751045 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,11368862 0,16740321 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,11368862 0,16729611 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,11368862 0,16718914 ! gene silencing by RNA GO:0031047 20 14 0,000 0,11368862 0,16708231 ! response to cAMP GO:0051591 19 14 0,000 0,11368862 0,16697562 ! limbic system development GO:0021761 25 14 0,000 0,11368862 0,16686906 ! startle response GO:0001964 21 14 0,000 0,11368862 0,16676264 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,11368862 0,16665635 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,11368862 0,1665502 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,11368862 0,16644419 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,11368862 0,16633831 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,11368862 0,16623256 ! glycine metabolic process GO:0006544 22 14 0,000 0,11368862 0,16612695 ! pituitary gland development GO:0021983 23 14 0,000 0,11368862 0,16602147 ! negative regulation of microtubule depolymerization GO:0007026 31 14 0,000 0,11368862 0,16591613 GO:0031114|regulation of microtubule depolymerization, ! lysosomal transport GO:0007041 20 14 0,000 0,11368862 0,16581092 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,11368862 0,16570584 ! negative regulation of caspase activity GO:0043154 20 14 0,000 0,11368862 0,1656009 ! embryo implantation GO:0007566 27 14 0,000 0,11368862 0,16549609 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,11368862 0,16539141 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,11368862 0,16528686 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,11368862 0,16518245 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,11368862 0,16507817 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,11368862 0,16497402 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,11368862 0,16487 ! mRNA splice site selection GO:0006376 26 14 0,000 0,11368862 0,16476611 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,11368862 0,16466235 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,11368862 0,16455873 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,11368862 0,16445523 GO:0046466|membrane lipid catabolic process, ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,11368862 0,16435186 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,11368862 0,16424863 ! muscle maintenance GO:0046716 19 14 0,000 0,11368862 0,16414552 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,11368862 0,16404255 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,11368862 0,1639397 ! cell killing GO:0001906 20 14 0,000 0,11368862 0,16383698 ! cilium assembly GO:0042384 20 14 0,000 0,11368862 0,16373439 ! learning or memory GO:0007611 123 68 1,000 0,11562518 0,16641922 ! cytosolic calcium ion homeostasis GO:0051480 107 68 1,000 0,11562518 0,16631515 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,11562518 0,1662112 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,11562518 0,16610738 ! rhythmic process GO:0048511 105 68 1,000 0,11562518 0,1660037 ! activation of protein kinase activity GO:0032147 102 69 1,000 0,11843543 0,16993231 ! regulation of catabolic process GO:0009894 106 70 1,000 0,12126277 0,17388053 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,12129949 0,17382481 ! skin development GO:0043588 25 15 0,000 0,12129949 0,17371658 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,12129949 0,17360848 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,12129949 0,17350051 ! lipid phosphorylation GO:0046834 23 15 0,000 0,12129949 0,17339268 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,12129949 0,17328498 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,12129949 0,17317742 ! bile acid metabolic process GO:0008206 22 15 0,000 0,12129949 0,17306999 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,12129949 0,17296269 ! adult walking behavior GO:0007628 25 15 0,000 0,12129949 0,17285553 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,12129949 0,1727485 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,12129949 0,1726416 ! myoblast differentiation GO:0045445 27 15 0,000 0,12129949 0,17253483 ! centrosome cycle GO:0007098 16 15 0,000 0,12129949 0,1724282 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,12129949 0,17232169 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,12129949 0,17221532 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,12129949 0,17210908 ! cerebral cortex development GO:0021987 29 15 0,000 0,12129949 0,17200297 ! response to osmotic stress GO:0006970 22 15 0,000 0,12129949 0,17189699 ! vesicle coating GO:0006901 25 15 0,000 0,12129949 0,17179115 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,12129949 0,17168543 ! DNA integration GO:0015074 22 15 0,000 0,12129949 0,17157984 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,12129949 0,17147438 ! regulation of vasodilation GO:0042312 24 15 0,000 0,12129949 0,17136906 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,12129949 0,17126386 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,12129949 0,17115879 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,12129949 0,17105385 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,12129949 0,17094903 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,12129949 0,17084435 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,12129949 0,17073979 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,12129949 0,17063537 ! dopamine metabolic process GO:0042417 30 15 0,000 0,12129949 0,17053106 ! organic cation transport GO:0015695 19 15 0,000 0,12129949 0,17042689 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,12129949 0,17032285 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,12129949 0,17021893 ! peptide hormone processing GO:0016486 19 15 0,000 0,12129949 0,17011514 ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 0,000 0,12129949 0,17001147 ! muscle cell differentiation GO:0042692 104 71 1,000 0,1241067 0,17384008 ! steroid biosynthetic process GO:0006694 94 71 1,000 0,1241067 0,17373428 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,12696675 0,17762988 ! regulation of synaptic transmission GO:0050804 109 72 1,000 0,12696675 0,17752189 ! protein secretion GO:0009306 27 16 0,000 0,12884544 0,18003919 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,12884544 0,17992987 ! bone remodeling GO:0046849 24 16 0,000 0,12884544 0,17982069 ! endothelial cell migration GO:0043542 22 16 0,000 0,12884544 0,17971165 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,12884544 0,17960273 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,12884544 0,17949394 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,12884544 0,17938529 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,12884544 0,17927677 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,12884544 0,17916838 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,12884544 0,17906012 ! protein polyubiquitination GO:0000209 26 16 0,000 0,12884544 0,17895199 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,12884544 0,178844 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,12884544 0,17873613 ! fructose metabolic process GO:0006000 20 16 0,000 0,12884544 0,17862839 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,12884544 0,17852078 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,12884544 0,17841331 ! protein export from nucleus GO:0006611 24 16 0,000 0,12884544 0,17830596 ! negative regulation of immune response GO:0050777 28 16 0,000 0,12884544 0,17819874 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,12884544 0,17809165 ! DNA replication initiation GO:0006270 25 16 0,000 0,12884544 0,17798469 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,12884544 0,17787785 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,12884544 0,17777115 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,12884544 0,17766457 ! diencephalon development GO:0021536 25 16 0,000 0,12884544 0,17755812 ! neural crest cell migration GO:0001755 24 16 0,000 0,12884544 0,1774518 ! detection of biotic stimulus GO:0009595 19 16 0,000 0,12884544 0,1773456 ! steroid catabolic process GO:0006706 22 16 0,000 0,12884544 0,17723954 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,12884544 0,17713359 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,12884544 0,17702778 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,12884544 0,17692209 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,12884544 0,17681653 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,12884544 0,17671109 ! sperm-egg recognition GO:0035036 16 16 0,000 0,12884544 0,17660578 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,12884544 0,1765006 ! nerve development GO:0021675 18 16 0,000 0,12884544 0,17639554 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,12884544 0,1762906 ! negative regulation of translation GO:0017148 22 16 0,000 0,12884544 0,17618579 ! regulation of blood pressure GO:0008217 107 73 1,000 0,12984241 0,17744359 ! response to steroid hormone stimulus GO:0048545 114 73 1,000 0,12984241 0,17733822 ! digestion GO:0007586 97 74 1,000 0,13273324 0,1811789 ! protein import into nucleus GO:0006606 118 74 1,000 0,13273324 0,18107144 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,13273324 0,18096411 ! nuclear import GO:0051170 121 75 1,000 0,13563875 0,18481583 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,13632701 0,18564365 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,13632701 0,1855338 ! negative regulation of defense response GO:0031348 19 17 0,000 0,13632701 0,18542408 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,13632701 0,18531449 ! glycerol metabolic process GO:0006071 20 17 0,000 0,13632701 0,18520504 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,13632701 0,18509571 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,13632701 0,1849865 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,13632701 0,18487743 ! signal complex assembly GO:0007172 29 17 0,000 0,13632701 0,18476849 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,13632701 0,18465967 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,13632701 0,18455099 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,13632701 0,18444243 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,13632701 0,18433399 ! memory GO:0007613 25 17 0,000 0,13632701 0,18422569 ! keratinization GO:0031424 17 17 0,000 0,13632701 0,18411751 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,13632701 0,18400946 ! negative regulation of peptidase activity GO:0010466 23 17 0,000 0,13632701 0,18390154 ! retinoid metabolic process GO:0001523 22 17 0,000 0,13632701 0,18379374 GO:0016101|diterpenoid metabolic process, ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,13632701 0,18368607 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,13632701 0,18357853 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,13632701 0,18347111 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,13632701 0,18336382 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,13632701 0,18325665 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,13632701 0,18314961 ! membrane budding GO:0006900 29 17 0,000 0,13632701 0,18304269 ! heme metabolic process GO:0042168 27 17 0,000 0,13632701 0,1829359 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,13632701 0,18282923 ! stem cell differentiation GO:0048863 36 17 0,000 0,13632701 0,18272268 ! nucleobase metabolic process GO:0009112 31 17 0,000 0,13632701 0,18261626 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,13632701 0,18250997 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,13632701 0,1824038 ! sensory perception of pain GO:0019233 23 17 0,000 0,13632701 0,18229775 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,13632701 0,18219182 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,13632701 0,18208602 ! synaptogenesis GO:0007416 24 17 0,000 0,13632701 0,18198034 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,13632701 0,18187478 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,13632701 0,18176935 ! cell-cell junction organization GO:0045216 25 17 0,000 0,13632701 0,18166404 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,13632701 0,18155884 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,13632701 0,18145378 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,13632701 0,18134883 ! response to unfolded protein GO:0006986 99 76 1,000 0,13855848 0,1842107 ! regulation of protein transport GO:0051223 114 76 1,000 0,13855848 0,18410428 GO:0070201|regulation of establishment of protein localization, ! regulation of DNA binding GO:0051101 119 77 1,000 0,14149199 0,18789352 ! sex differentiation GO:0007548 105 77 1,000 0,14149199 0,1877851 ! protein ubiquitination GO:0016567 125 77 1,000 0,14149199 0,1876768 ! regulation of transmission of nerve impulse GO:0051969 116 77 1,000 0,14149199 0,18756863 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,14374476 0,19044524 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,14374476 0,1903356 ! positive regulation of translation GO:0045727 28 18 0,000 0,14374476 0,19022609 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,14374476 0,1901167 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,14374476 0,19000744 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,14374476 0,1898983 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,14374476 0,18978929 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,14374476 0,1896804 ! axis specification GO:0009798 26 18 0,000 0,14374476 0,18957164 ! pancreas development GO:0031016 26 18 0,000 0,14374476 0,189463 ! glutamine metabolic process GO:0006541 23 18 0,000 0,14374476 0,18935449 ! response to retinoic acid GO:0032526 25 18 0,000 0,14374476 0,1892461 ! pigmentation during development GO:0048066 31 18 0,000 0,14374476 0,18913784 ! fucose metabolic process GO:0006004 26 18 0,000 0,14374476 0,1890297 ! response to fungus GO:0009620 19 18 0,000 0,14374476 0,18892168 ! peptide cross-linking GO:0018149 31 18 0,000 0,14374476 0,18881379 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,14374476 0,18870602 ! heart process GO:0003015 27 18 0,000 0,14374476 0,18859837 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,14374476 0,18849085 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,14374476 0,18838344 ! visual learning GO:0008542 35 18 0,000 0,14374476 0,18827616 ! somitogenesis GO:0001756 24 18 0,000 0,14374476 0,18816901 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,14374476 0,18806197 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,14374476 0,18795506 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,14374476 0,18784826 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,14374476 0,18774159 ! vitamin transport GO:0051180 24 18 0,000 0,14374476 0,18763504 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,14374476 0,18752861 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,14374476 0,1874223 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,14374476 0,18731611 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,14374476 0,18721005 ! cell-cell recognition GO:0009988 20 18 0,000 0,14374476 0,1871041 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,14374476 0,18699827 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,14374476 0,18689256 ! regulation of glucose import GO:0046324 21 18 0,000 0,14374476 0,18678697 GO:0010827|regulation of glucose transport, ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,14443882 0,18758289 ! regulation of cAMP biosynthetic process GO:0030817 136 79 1,000 0,14739854 0,19131865 ! regulation of GTPase activity GO:0043087 129 80 1,000 0,15037071 0,19506635 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,15109922 0,1959009 ! positive regulation of fibroblast proliferation GO:0048146 27 19 0,000 0,15109922 0,19579054 ! positive regulation of ossification GO:0045778 30 19 0,000 0,15109922 0,19568029 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,15109922 0,19557017 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,15109922 0,19546018 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,15109922 0,19535031 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,15109922 0,19524056 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,15109922 0,19513094 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,15109922 0,19502144 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,15109922 0,19491206 ! sensory perception of taste GO:0050909 23 19 0,000 0,15109922 0,1948028 ! peroxisome organization GO:0007031 29 19 0,000 0,15109922 0,19469367 ! digestive system process GO:0022600 30 19 0,000 0,15109922 0,19458466 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,15109922 0,19447577 ! response to vitamin A GO:0033189 26 19 0,000 0,15109922 0,194367 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,15109922 0,19425836 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,15109922 0,19414983 ! sex determination GO:0007530 29 19 0,000 0,15109922 0,19404143 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,15109922 0,19393315 ! plasma membrane fusion GO:0045026 23 19 0,000 0,15109922 0,19382499 ! cytolysis GO:0019835 20 19 0,000 0,15109922 0,19371695 ! vasodilation GO:0042311 33 19 0,000 0,15109922 0,19360903 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,15109922 0,19350122 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,15109922 0,19339354 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,15109922 0,19328598 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,15109922 0,19317854 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,15109922 0,19307122 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,15109922 0,19296402 ! sarcomere organization GO:0045214 23 19 0,000 0,15109922 0,19285694 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,15109922 0,19274997 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,15109922 0,19264313 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,15109922 0,1925364 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,15109922 0,19242979 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,15109922 0,1923233 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,15109922 0,19221692 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 0,000 0,15109922 0,19211067 ! protein stabilization GO:0050821 26 19 0,000 0,15109922 0,19200453 ! regulation of cAMP metabolic process GO:0030814 141 81 1,000 0,15335491 0,19476328 ! regulation of neurological system process GO:0031644 122 81 1,000 0,15335491 0,19465579 ! ossification GO:0001503 134 82 1,000 0,15635071 0,19834894 GO:0060348|bone development, ! detection of stimulus GO:0051606 108 82 1,000 0,15635071 0,1982396 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,15839093 0,20071577 ! iron ion transport GO:0006826 37 20 0,000 0,15839093 0,20060525 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,15839093 0,20049484 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,15839093 0,20038456 GO:0006044|N-acetylglucosamine metabolic process, ! response to vitamin GO:0033273 29 20 0,000 0,15839093 0,2002744 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,15839093 0,20016436 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,15839093 0,20005444 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,15839093 0,19994464 ! spinal cord development GO:0021510 31 20 0,000 0,15839093 0,19983496 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,15839093 0,1997254 ! chromosome condensation GO:0030261 31 20 0,000 0,15839093 0,19961596 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,15839093 0,19950664 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,15839093 0,19939744 ! pallium development GO:0021543 38 20 0,000 0,15839093 0,19928836 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,15839093 0,1991794 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,15839093 0,19907056 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,15839093 0,19896184 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,15839093 0,19885324 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,15839093 0,19874475 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,15839093 0,19863639 ! collagen catabolic process GO:0030574 25 20 0,000 0,15839093 0,19852814 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,15839093 0,19842001 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,15839093 0,19831199 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,15839093 0,1982041 ! alditol metabolic process GO:0019400 24 20 0,000 0,15839093 0,19809632 ! actin filament-based movement GO:0030048 34 20 0,000 0,15839093 0,19798866 ! regulation of nucleotide biosynthetic process GO:0030808 141 83 1,000 0,1593577 0,19908892 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,16237547 0,20274896 ! rRNA metabolic process GO:0016072 107 85 1,000 0,16540362 0,20641797 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,16540362 0,20630603 ! anterior/posterior pattern formation GO:0009952 124 85 1,000 0,16540362 0,20619421 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,16562042 0,20635263 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,16562042 0,20624091 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,16562042 0,20612931 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,16562042 0,20601783 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,16562042 0,20590646 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,16562042 0,20579522 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,16562042 0,2056841 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,16562042 0,2055731 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,16562042 0,20546222 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,16562042 0,20535146 ! protein amino acid acylation GO:0043543 37 21 0,000 0,16562042 0,20524082 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,16562042 0,2051303 ! vesicle docking GO:0048278 27 21 0,000 0,16562042 0,20501989 ! phototransduction GO:0007602 25 21 0,000 0,16562042 0,20490961 ! visual behavior GO:0007632 39 21 0,000 0,16562042 0,20479944 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,16562042 0,20468939 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,16562042 0,20457946 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,16562042 0,20446965 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,16562042 0,20435996 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,16562042 0,20425038 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,16562042 0,20414092 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,16562042 0,20403158 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,16562042 0,20392235 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,16562042 0,20381325 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,16562042 0,20370426 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,16562042 0,20359538 ! fatty acid transport GO:0015908 30 21 0,000 0,16562042 0,20348662 ! immunoglobulin production GO:0002377 33 21 0,000 0,16562042 0,20337798 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,16562042 0,20326946 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,16562042 0,20316104 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,16562042 0,20305275 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,16562042 0,20294457 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,16562042 0,20283651 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,16562042 0,20272856 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,16562042 0,20262072 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,16562042 0,202513 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,16562042 0,2024054 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,16562042 0,20229791 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,16562042 0,20219053 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,16562042 0,20208327 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 1,000 0,16844175 0,20541676 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,17148947 0,20902267 GO:0060538|skeletal muscle organ development, ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,17148947 0,20891196 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,17278822 0,21038269 ! viral genome replication GO:0019079 29 22 0,000 0,17278822 0,21027137 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,17278822 0,21016018 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,17278822 0,2100491 ! leukocyte adhesion GO:0007159 38 22 0,000 0,17278822 0,20993814 ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,17278822 0,20982729 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,17278822 0,20971657 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,17278822 0,20960596 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,17278822 0,20949546 GO:0051297|centrosome organization, ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,17278822 0,20938509 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! lysosome organization GO:0007040 37 22 0,000 0,17278822 0,20927483 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,17278822 0,20916468 GO:0051693|actin filament capping, ! coenzyme catabolic process GO:0009109 33 22 0,000 0,17278822 0,20905465 ! regulation of behavior GO:0050795 38 22 0,000 0,17278822 0,20894474 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,17278822 0,20883494 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,17278822 0,20872526 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,17278822 0,20861569 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,17278822 0,20850624 ! neural tube closure GO:0001843 33 22 0,000 0,17278822 0,2083969 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! protein processing GO:0016485 114 88 1,000 0,17454639 0,21040708 ! reproductive developmental process GO:0003006 127 89 1,000 0,17761215 0,21399054 ! regulation of nucleotide metabolic process GO:0006140 150 89 1,000 0,17761215 0,2138785 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,17989485 0,21651394 ! neuron fate commitment GO:0048663 32 23 0,000 0,17989485 0,2164007 ! embryonic pattern specification GO:0009880 31 23 0,000 0,17989485 0,21628758 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,17989485 0,21617458 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,17989485 0,2160617 ! vesicle targeting GO:0006903 32 23 0,000 0,17989485 0,21594893 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 0,000 0,17989485 0,21583628 ! osteoblast differentiation GO:0001649 40 23 0,000 0,17989485 0,21572375 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,17989485 0,21561133 ! interaction with host GO:0051701 37 23 0,000 0,17989485 0,21549903 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,17989485 0,21538685 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,17989485 0,21527479 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,17989485 0,21516284 ! cell fate determination GO:0001709 45 23 0,000 0,17989485 0,21505101 ! pentose metabolic process GO:0019321 31 23 0,000 0,17989485 0,2149393 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,17989485 0,2148277 ! spermatid development GO:0007286 33 23 0,000 0,17989485 0,21471622 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,17989485 0,21460485 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,17989485 0,2144936 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,17989485 0,21438246 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,17989485 0,21427144 ! telomere organization GO:0032200 32 23 0,000 0,17989485 0,21416053 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,17989485 0,21404974 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,17989485 0,21393906 ! regulation of amine transport GO:0051952 38 23 0,000 0,17989485 0,2138285 ! liver development GO:0001889 40 23 0,000 0,17989485 0,21371805 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,18068636 0,21454756 ! ATP metabolic process GO:0046034 137 91 1,000 0,18376866 0,2180949 ! response to virus GO:0009615 122 91 1,000 0,18376866 0,21798242 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,18694083 0,22163088 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,18694083 0,22151669 ! initiation of viral infection GO:0019059 42 24 0,000 0,18694083 0,22140263 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,18694083 0,22128868 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,18694083 0,22117485 ! superoxide metabolic process GO:0006801 32 24 0,000 0,18694083 0,22106113 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,18694083 0,22094753 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,18694083 0,22083405 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,18694083 0,22072069 ! sperm motility GO:0030317 27 24 0,000 0,18694083 0,22060744 ! vacuole organization GO:0007033 39 24 0,000 0,18694083 0,22049431 ! receptor metabolic process GO:0043112 37 24 0,000 0,18694083 0,22038129 ! primary neural tube formation GO:0014020 35 24 0,000 0,18694083 0,22026839 ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,18694083 0,22015561 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,18694083 0,22004294 GO:0002708|positive regulation of lymphocyte mediated immunity, ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,18694083 0,21993038 ! glutathione metabolic process GO:0006749 29 24 0,000 0,18694083 0,21981795 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,18694083 0,21970562 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,18694083 0,21959341 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,18995607 0,22302142 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,18995607 0,22290763 ! polysaccharide metabolic process GO:0005976 129 93 1,000 0,18995607 0,22279396 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,19392667 0,22733504 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,19392667 0,22721923 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,19392667 0,22710354 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,19392667 0,22698796 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,19392667 0,2268725 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,19392667 0,22675717 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,19392667 0,22664194 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,19392667 0,22652684 ! phospholipid transport GO:0015914 35 25 0,000 0,19392667 0,22641185 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,19392667 0,22629698 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,19392667 0,22618222 ! detection of light stimulus GO:0009583 30 25 0,000 0,19392667 0,22606758 ! peptidyl-tyrosine modification GO:0018212 37 25 0,000 0,19392667 0,22595306 ! angiogenesis GO:0001525 149 95 1,000 0,19617156 0,22845296 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,19928898 0,23196592 ! regulation of cellular component biogenesis GO:0044087 158 96 1,000 0,19928898 0,23184858 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,19928898 0,23173137 ! protein maturation GO:0051604 129 96 1,000 0,19928898 0,23161427 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,20085289 0,23331396 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 0,000 0,20085289 0,23319619 ! circadian rhythm GO:0007623 42 26 0,000 0,20085289 0,23307853 ! negative regulation of protein modification process GO:0031400 50 26 0,000 0,20085289 0,23296099 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,20085289 0,23284357 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,20085289 0,23272627 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,20085289 0,23260909 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 0,000 0,20085289 0,23249202 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,20085289 0,23237507 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,20085289 0,23225824 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,20085289 0,23214153 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 1,000 0,20241239 0,23382647 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,20771999 0,23983734 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,20771999 0,239717 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,20771999 0,23959678 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,20771999 0,23947668 ! membrane docking GO:0022406 39 27 0,000 0,20771999 0,2393567 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,20771999 0,23923684 ! catechol metabolic process GO:0009712 43 27 0,000 0,20771999 0,2391171 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,20771999 0,23899749 ! acute-phase response GO:0006953 42 27 0,000 0,20771999 0,23887799 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,20771999 0,23875861 ! myofibril assembly GO:0030239 36 27 0,000 0,20771999 0,23863935 GO:0055002|striated muscle cell development, ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,20771999 0,23852021 ! natural killer cell activation GO:0030101 35 27 0,000 0,20771999 0,23840118 ! cofactor catabolic process GO:0051187 45 27 0,000 0,20771999 0,23828228 ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,20771999 0,2381635 ! gene silencing GO:0016458 41 27 0,000 0,20771999 0,23804483 ! extracellular structure organization GO:0043062 156 99 1,000 0,2086759 0,2390212 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 1,000 0,21181536 0,24249642 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,21181536 0,24237578 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,21452847 0,24535827 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,21452847 0,24523632 ! phenol metabolic process GO:0018958 44 28 0,000 0,21452847 0,24511449 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,21452847 0,24499279 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,21452847 0,2448712 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,21452847 0,24474974 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,21452847 0,2446284 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,21452847 0,24450717 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,21452847 0,24438607 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,21452847 0,24426509 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,21452847 0,24414422 GO:0002764|immune response-regulating signal transduction, ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,21452847 0,24402348 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,21452847 0,24390285 ! mesoderm formation GO:0001707 46 28 0,000 0,21452847 0,24378235 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,21452847 0,24366196 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,21452847 0,2435417 ! BMP signaling pathway GO:0030509 40 28 0,000 0,21452847 0,24342155 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,21452847 0,24330152 ! neural tube formation GO:0001841 41 28 0,000 0,21452847 0,2431816 ! regulation of innate immune response GO:0045088 38 29 0,000 0,22127882 0,25071 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,22127882 0,25058656 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,22127882 0,25046324 ! mismatch repair GO:0006298 34 29 0,000 0,22127882 0,25034004 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,22127882 0,25021696 ! muscle cell development GO:0055001 38 29 0,000 0,22127882 0,250094 ! formation of primary germ layer GO:0001704 48 29 0,000 0,22127882 0,24997117 ! telencephalon development GO:0021537 52 29 0,000 0,22127882 0,24984845 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,22127882 0,24972586 ! eye morphogenesis GO:0048592 51 29 0,000 0,22127882 0,24960338 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,22127882 0,24948103 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,22797155 0,25690082 ! collagen metabolic process GO:0032963 40 30 0,000 0,22797155 0,25677501 ! organic anion transport GO:0015711 51 30 0,000 0,22797155 0,25664932 ! cholesterol transport GO:0030301 46 30 0,000 0,22797155 0,25652376 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,22797155 0,25639832 ! spliceosome assembly GO:0000245 49 30 0,000 0,22797155 0,25627301 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,22797155 0,25614781 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,22797155 0,25602274 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,22797155 0,25589779 ! ceramide metabolic process GO:0006672 43 30 0,000 0,22797155 0,25577296 ! adult locomotory behavior GO:0008344 47 30 0,000 0,22797155 0,25564825 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,22797155 0,25552367 ! regulation of microtubule-based process GO:0032886 58 30 0,000 0,22797155 0,25539921 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,22797155 0,25527486 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,22797155 0,25515064 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,23460714 0,26244962 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,23460714 0,26232203 ! odontogenesis GO:0042476 50 31 0,000 0,23460714 0,26219457 ! segmentation GO:0035282 41 31 0,000 0,23460714 0,26206723 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,23460714 0,26194001 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,23460714 0,26181292 ! cell fate specification GO:0001708 37 31 0,000 0,23460714 0,26168595 ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,23460714 0,2615591 ! RNA modification GO:0009451 40 31 0,000 0,23460714 0,26143237 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,24118607 0,2686334 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,24118607 0,26850337 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,24118607 0,26837347 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,24118607 0,2682437 ! cytokine production GO:0001816 44 32 0,000 0,24118607 0,26811405 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,24118607 0,26798452 ! vesicle localization GO:0051648 47 32 0,000 0,24118607 0,26785512 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,24770883 0,27496636 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,24770883 0,27483372 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,24770883 0,27470121 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,24770883 0,27456882 ! actomyosin structure organization GO:0031032 43 33 0,000 0,24770883 0,27443656 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,24770883 0,27430443 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,24770883 0,27417243 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,24770883 0,27404055 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,24770883 0,2739088 ! lipid homeostasis GO:0055088 55 33 0,000 0,24770883 0,27377717 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,24770883 0,27364568 ! regulation of proteolysis GO:0030162 50 33 0,000 0,24770883 0,27351431 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,24770883 0,27338306 ! mRNA catabolic process GO:0006402 48 34 0,000 0,25417588 0,28038587 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,25417588 0,28025145 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,25417588 0,28011717 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,25417588 0,27998301 ! feeding behavior GO:0007631 45 34 0,000 0,25417588 0,27984899 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,25417588 0,27971509 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,25417588 0,27958132 ! polyol metabolic process GO:0019751 44 34 0,000 0,25417588 0,27944767 ! aerobic respiration GO:0009060 47 34 0,000 0,25417588 0,27931416 ! embryonic organ development GO:0048568 45 34 0,000 0,25417588 0,27918077 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,25417588 0,27904751 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,26058771 0,28595026 ! Notch signaling pathway GO:0007219 56 35 0,000 0,26058771 0,2858139 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,26058771 0,28567767 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,26058771 0,28554156 GO:0032313|regulation of Rab GTPase activity, ! keratinocyte differentiation GO:0030216 47 35 0,000 0,26058771 0,28540559 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,26058771 0,28526975 GO:0015986|ATP synthesis coupled proton transport, ! Rho protein signal transduction GO:0007266 51 35 0,000 0,26058771 0,28513403 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,26058771 0,28499845 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,26058771 0,28486299 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,26694479 0,29167364 GO:0090047|positive regulation of transcription regulator activity, ! cellular amide metabolic process GO:0043603 52 36 0,000 0,26694479 0,29153514 ! tissue remodeling GO:0048771 62 36 0,000 0,26694479 0,29139678 ! neural tube development GO:0021915 50 36 0,000 0,26694479 0,29125854 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,26694479 0,29112044 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,26694479 0,29098247 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,26694479 0,29084463 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,27324757 0,29757074 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,27324757 0,29742991 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,27324757 0,29728921 ! ion transmembrane transport GO:0034220 56 37 0,000 0,27324757 0,29714865 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,27324757 0,29700822 ! regulation of protein secretion GO:0050708 51 37 0,000 0,27324757 0,29686793 ! amino acid activation GO:0043038 52 37 0,000 0,27324757 0,29672776 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,27324757 0,29658773 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,27949651 0,30322735 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,27949651 0,30308438 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,27949651 0,30294155 ! phagocytosis GO:0006909 60 38 0,000 0,27949651 0,30279886 ! negative regulation of protein complex disassembly GO:0043242 67 39 0,000 0,28569208 0,30936525 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,28569208 0,30921966 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,28569208 0,30907422 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,28569208 0,30892891 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,28569208 0,30878373 ! chromatin remodeling GO:0006338 68 39 0,000 0,28569208 0,3086387 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,28569208 0,3084938 ! JNK cascade GO:0007254 54 39 0,000 0,28569208 0,30834903 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,29183473 0,31483109 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,29183473 0,31468349 ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,29183473 0,31453602 ! peptide metabolic process GO:0006518 56 40 0,000 0,29183473 0,3143887 ! epidermal cell differentiation GO:0009913 53 40 0,000 0,29183473 0,31424151 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,29183473 0,31409447 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,2979249 0,32049919 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,2979249 0,32034936 ! striated muscle contraction GO:0006941 62 41 0,000 0,2979249 0,32019966 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,2979249 0,3200501 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,2979249 0,31990069 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,30396304 0,32623192 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,30396304 0,32607976 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,30396304 0,32592774 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,30396304 0,32577586 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,30396304 0,32562413 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,30396304 0,32547253 ! regulation of cell shape GO:0008360 78 42 0,000 0,30396304 0,32532108 ! positive regulation of binding GO:0051099 59 43 0,000 0,3099496 0,33157399 ! neuromuscular process GO:0050905 79 43 0,000 0,3099496 0,33141984 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,3099496 0,33126584 ! tRNA processing GO:0008033 49 43 0,000 0,3099496 0,33111197 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,3099496 0,33095826 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,31588501 0,33713945 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,31588501 0,33698308 ! glycolysis GO:0006096 53 44 0,000 0,31588501 0,33682685 ! regulation of ion transport GO:0043269 57 44 0,000 0,31588501 0,33667077 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,31588501 0,33651483 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,31588501 0,33635904 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,31588501 0,33620339 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,31588501 0,33604788 ! RNA catabolic process GO:0006401 64 45 0,000 0,3217697 0,34214993 ! positive regulation of defense response GO:0031349 59 45 0,000 0,3217697 0,34199182 ! regulation of translational initiation GO:0006446 64 45 0,000 0,3217697 0,34183386 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,3217697 0,34167604 ! cell maturation GO:0048469 60 45 0,000 0,3217697 0,34151837 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,32760411 0,34755048 ! regulation of protein complex disassembly GO:0043244 77 46 0,000 0,32760411 0,34739025 ! cell redox homeostasis GO:0045454 63 46 0,000 0,32760411 0,34723016 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,32760411 0,34707022 ! histone modification GO:0016570 68 46 0,000 0,32760411 0,34691042 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,32760411 0,34675078 ! viral infectious cycle GO:0019058 71 47 0,000 0,33338865 0,35271109 ! endocrine system development GO:0035270 83 47 0,000 0,33338865 0,35254892 ! covalent chromatin modification GO:0016569 75 47 0,000 0,33338865 0,3523869 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,33338865 0,35222504 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,33338865 0,35206332 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,33338865 0,35190175 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,33338865 0,35174032 ! chloride transport GO:0006821 67 48 0,000 0,33912377 0,35762708 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,33912377 0,35746318 ! gastrulation GO:0007369 73 48 0,000 0,33912377 0,35729943 ! heart morphogenesis GO:0003007 65 48 0,000 0,33912377 0,35713584 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,33912377 0,35697239 GO:0019724|B cell mediated immunity, ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,33912377 0,35680909 ! regulation of endocytosis GO:0030100 63 48 0,000 0,33912377 0,35664594 ! nuclear export GO:0051168 69 48 0,000 0,33912377 0,35648294 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,33912377 0,35632008 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,34480987 0,36212908 ! sensory perception of smell GO:0007608 61 49 0,000 0,34480987 0,3619638 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,34480987 0,36179867 ! RNA elongation GO:0006354 62 49 0,000 0,34480987 0,36163369 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,34480987 0,36146887 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,34480987 0,36130419 ! regulation of actin filament length GO:0030832 72 50 0,000 0,35044736 0,36704414 ! membrane fusion GO:0006944 80 50 0,000 0,35044736 0,36687708 ! negative regulation of cytoskeleton organization GO:0051494 84 50 0,000 0,35044736 0,36671016 ! proton transport GO:0015992 75 50 0,000 0,35044736 0,3665434 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,35044736 0,36637679 ! hydrogen transport GO:0006818 77 51 0,000 0,35603668 0,37205105 ! adult behavior GO:0030534 80 51 0,000 0,35603668 0,37188209 ! transition metal ion transport GO:0000041 74 52 0,000 0,36157821 0,37749881 ! regulation of cellular component size GO:0032535 74 52 0,000 0,36157821 0,37732754 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,36157821 0,37715641 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,36707238 0,38271372 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,36707238 0,38254031 ! single fertilization GO:0007338 59 53 0,000 0,36707238 0,38236706 ! cell projection assembly GO:0030031 76 53 0,000 0,36707238 0,38219396 ! amino acid transport GO:0006865 84 54 0,000 0,37251957 0,38769005 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,37251957 0,3875147 ! glucose catabolic process GO:0006007 66 54 0,000 0,37251957 0,38733952 ! exocytosis GO:0006887 74 55 0,000 0,37792019 0,39277743 ! mesoderm development GO:0007498 76 55 0,000 0,37792019 0,39260002 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,37792019 0,39242277 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,37792019 0,39224569 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,38327464 0,39762367 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,38858331 0,40294933 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,38858331 0,40276774 ! camera-type eye development GO:0043010 88 57 0,000 0,38858331 0,40258631 ! developmental maturation GO:0021700 75 57 0,000 0,38858331 0,40240504 ! viral reproductive process GO:0022415 87 58 0,000 0,39384658 0,40767198 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,39384658 0,40748859 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,39384658 0,40730536 ! activation of MAPK activity GO:0000187 84 59 0,000 0,39906484 0,41251646 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,40423848 0,41767677 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,40423848 0,41748922 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,40423848 0,41730184 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,40423848 0,41711462 ! fertilization GO:0009566 68 60 0,000 0,40423848 0,41692758 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,40936787 0,42202873 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,40936787 0,42183965 ! extracellular matrix organization GO:0030198 103 61 0,000 0,40936787 0,42165074 ! neurotransmitter transport GO:0006836 81 62 0,000 0,41445339 0,42669776 ! lymphocyte mediated immunity GO:0002449 88 62 0,000 0,41445339 0,42650684 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,41949541 0,43150243 ! viral reproduction GO:0016032 92 63 0,000 0,41949541 0,43130954 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,4244943 0,43625419 ! hexose catabolic process GO:0019320 82 64 0,000 0,4244943 0,43605935 ! adaptive immune response GO:0002250 94 64 0,000 0,4244943 0,43586468 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! defense response to bacterium GO:0042742 73 65 0,000 0,42945043 0,4407568 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,42945043 0,44056021 ! activation of immune response GO:0002253 83 65 0,000 0,42945043 0,44036379 ! antigen processing and presentation GO:0019882 96 66 0,000 0,43436416 0,4452039 ! regulation of immune effector process GO:0002697 101 66 0,000 0,43436416 0,44500559 ! acute inflammatory response GO:0002526 92 68 0,000 0,44406586 0,45474242 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,44406586 0,45454004 ! inorganic anion transport GO:0015698 93 68 0,000 0,44406586 0,45433784 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,44885454 0,4590331 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,45360225 0,4636823 ! eye development GO:0001654 111 70 0,000 0,45360225 0,46347631 ! amine transport GO:0015837 101 70 0,000 0,45360225 0,4632705 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,45360225 0,46306488 ! leukocyte mediated immunity GO:0002443 99 71 0,000 0,45830933 0,46766258 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,45830933 0,46745519 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,47219024 0,48139962 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,47219024 0,48118633 ! blood coagulation GO:0007596 116 75 0,000 0,47673823 0,48560581 GO:0050817|coagulation, ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,47673823 0,48539085 ! amine biosynthetic process GO:0009309 97 76 0,000 0,48124729 0,48976495 ! tRNA metabolic process GO:0006399 95 76 0,000 0,48124729 0,48954833 ! regulation of cell morphogenesis GO:0022604 140 76 0,000 0,48124729 0,48933191 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,48571776 0,49365923 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,48571776 0,49344119 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,48571776 0,49322333 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,49014995 0,49750436 ! regulation of lyase activity GO:0051339 133 79 0,000 0,4945442 0,50174312 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,4945442 0,5015219 ! chromatin assembly GO:0031497 102 80 0,000 0,49890083 0,50571701 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,49890083 0,50549423 ! hemostasis GO:0007599 125 81 0,000 0,50322015 0,50964612 ! mRNA transport GO:0051028 121 81 0,000 0,50322015 0,50942181 ! vitamin metabolic process GO:0006766 103 81 0,000 0,50322015 0,50919769 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,50322015 0,50897377 GO:0002696|positive regulation of leukocyte activation, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,51174816 0,51737176 ! regulation of defense response GO:0031347 117 84 0,000 0,51595747 0,52139814 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,51595747 0,52116916 ! sterol metabolic process GO:0016125 120 84 0,000 0,51595747 0,52094038 ! nucleosome organization GO:0034728 114 87 0,000 0,52837032 0,53323903 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,52837032 0,53300515 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,52837032 0,53277148 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,53243727 0,53663703 ! establishment of RNA localization GO:0051236 128 88 0,000 0,53243727 0,53640198 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,53646937 0,54022747 ! RNA localization GO:0006403 135 91 0,000 0,54443025 0,54800419 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,5483596 0,55171789 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,5483596 0,55147665 ! positive regulation of immune response GO:0050778 121 92 0,000 0,5483596 0,55123562 ! DNA recombination GO:0006310 146 92 0,000 0,5483596 0,5509948 ! sulfur metabolic process GO:0006790 118 92 0,000 0,5483596 0,55075419 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,55225529 0,55442478 ! carboxylic acid transport GO:0046942 147 95 0,000 0,55994682 0,56190126 GO:0015849|organic acid transport, ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,56374322 0,56546419 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,56750708 0,5689914 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,5749383 0,57619089 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 0,000 0,5749383 0,57593994 ! regulation of translation GO:0006417 151 100 0,000 0,57860621 0,5793619 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,57860621 0,57910979 ! divalent metal ion transport GO:0070838 171 100 0,000 0,57860621 0,57885789 ! Ras protein signal transduction GO:0007265 162 100 0,000 0,57860621 0,57860621