pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6129-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! spindle assembly GO:0051225 5 5 3,000 8,677E-10 1,996E-06 ! pigmentation GO:0043473 74 38 5,000 5,247E-09 6,034E-06 ! natural killer cell mediated immunity GO:0002228 13 9 3,000 2,162E-08 1,658E-05 GO:0042267|natural killer cell mediated cytotoxicity, ! leukocyte mediated cytotoxicity GO:0001909 17 11 3,000 5,632E-08 3,238E-05 ! spindle organization GO:0007051 37 30 4,000 8,057E-08 3,706E-05 ! cell killing GO:0001906 20 14 3,000 1,694E-07 6,494E-05 ! microtubule cytoskeleton organization GO:0000226 120 84 5,000 6,762E-07 2,222E-04 ! polyamine metabolic process GO:0006595 14 10 2,000 5,779E-06 1,661E-03 ! protein sumoylation GO:0016925 12 10 2,000 5,779E-06 1,477E-03 ! cellular pigmentation GO:0033059 24 13 2,000 1,366E-05 3,142E-03 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 1,438E-05 3,007E-03 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,734E-05 3,324E-03 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 3,847E-05 6,806E-03 ! pigmentation during development GO:0048066 31 18 2,000 3,847E-05 6,32E-03 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 2,000 4,556E-05 6,986E-03 ! negative regulation of phosphorylation GO:0042326 41 23 2,000 8,238E-05 0,01184275 ! lymphocyte mediated immunity GO:0002449 88 62 3,000 8,257E-05 0,01117163 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 2,000 1,064E-04 0,01359884 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of chromosome organization GO:0033044 35 25 2,000 1,064E-04 0,01288311 ! epithelial cell proliferation GO:0050673 6 5 1,000 1,351E-04 0,01554176 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 1,351E-04 0,01480168 ! melanosome transport GO:0032402 8 5 1,000 1,351E-04 0,01412888 ! apical protein localization GO:0045176 6 5 1,000 1,351E-04 0,01351458 ! leukocyte mediated immunity GO:0002443 99 71 3,000 1,403E-04 0,01344201 ! response to exogenous dsRNA GO:0043330 8 6 1,000 2,022E-04 0,01860534 ! establishment of melanosome localization GO:0032401 9 6 1,000 2,022E-04 0,01788975 ! aspartate family amino acid catabolic process GO:0009068 7 6 1,000 2,022E-04 0,01722717 ! pigment granule transport GO:0051904 12 6 1,000 2,022E-04 0,01661191 ! mitotic sister chromatid segregation GO:0000070 45 32 2,000 2,253E-04 0,0178673 ! sister chromatid segregation GO:0000819 46 33 2,000 2,472E-04 0,01894855 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 2,824E-04 0,02095561 ! microtubule bundle formation GO:0001578 8 7 1,000 2,824E-04 0,02030075 ! asymmetric protein localization GO:0008105 8 7 1,000 2,824E-04 0,01968557 ! melanosome localization GO:0032400 10 7 1,000 2,824E-04 0,01910659 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 1,000 2,824E-04 0,01856068 ! establishment of pigment granule localization GO:0051905 13 7 1,000 2,824E-04 0,01804511 ! B cell receptor signaling pathway GO:0050853 11 7 1,000 2,824E-04 0,0175574 ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 1,000 3,757E-04 0,02273912 ! positive regulation of B cell proliferation GO:0030890 11 8 1,000 3,757E-04 0,02215607 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 3,757E-04 0,02160217 ! keratinocyte proliferation GO:0043616 12 8 1,000 3,757E-04 0,02107529 ! middle ear morphogenesis GO:0042474 9 8 1,000 3,757E-04 0,02057349 ! polyamine biosynthetic process GO:0006596 9 8 1,000 3,757E-04 0,02009504 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 1,000 3,757E-04 0,01963833 ! pigment granule localization GO:0051875 14 8 1,000 3,757E-04 0,01920193 ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 3,757E-04 0,01878449 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 1,000 3,757E-04 0,01838482 ! regulation of telomere maintenance GO:0032204 10 8 1,000 3,757E-04 0,01800181 ! regulation of myeloid cell differentiation GO:0045637 69 40 2,000 4,393E-04 0,02062155 ! L-serine metabolic process GO:0006563 13 9 1,000 4,819E-04 0,02216607 ! motor axon guidance GO:0008045 14 9 1,000 4,819E-04 0,02173144 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 1,000 4,819E-04 0,02131353 ! pyrimidine base metabolic process GO:0006206 14 9 1,000 4,819E-04 0,02091139 ! regulation of mast cell proliferation GO:0070666 64 44 2,000 5,827E-04 0,02481889 ! regulation of B cell proliferation GO:0030888 15 10 1,000 6,009E-04 0,0251283 ! melanocyte differentiation GO:0030318 15 10 1,000 6,009E-04 0,02467958 GO:0050931|pigment cell differentiation, ! response to dsRNA GO:0043331 18 10 1,000 6,009E-04 0,02424661 ! DNA methylation GO:0006306 15 10 1,000 6,009E-04 0,02382856 GO:0006305|DNA alkylation, ! T cell receptor signaling pathway GO:0050852 18 10 1,000 6,009E-04 0,02342469 ! regulation of leukocyte proliferation GO:0070663 71 47 2,000 7,078E-04 0,02713136 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! detection of mechanical stimulus GO:0050982 15 11 1,000 7,327E-04 0,02762508 ! focal adhesion formation GO:0048041 24 11 1,000 7,327E-04 0,02717952 ! serine family amino acid biosynthetic process GO:0009070 13 11 1,000 7,327E-04 0,0267481 ! digestive tract morphogenesis GO:0048546 15 11 1,000 7,327E-04 0,02633016 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 7,327E-04 0,02592508 GO:0042130|negative regulation of T cell proliferation, ! regulation of angiogenesis GO:0045765 94 49 2,000 7,999E-04 0,027877 ! positive regulation of cell growth GO:0030307 16 12 1,000 8,771E-04 0,03010908 ! Golgi organization GO:0007030 18 12 1,000 8,771E-04 0,0296663 ! heart looping GO:0001947 15 12 1,000 8,771E-04 0,02923636 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 2,000 8,994E-04 0,02955247 ! establishment of organelle localization GO:0051656 85 52 2,000 9,52E-04 0,03083836 ! endocrine pancreas development GO:0031018 19 13 1,000 1,034E-03 0,03303303 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 1,000 1,034E-03 0,03258053 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 1,204E-03 0,03740712 GO:0031114|regulation of microtubule depolymerization, ! negative regulation of caspase activity GO:0043154 20 14 1,000 1,204E-03 0,03690836 ! regulation of erythrocyte differentiation GO:0045646 27 14 1,000 1,204E-03 0,03642272 ! negative regulation of protein kinase activity GO:0006469 99 57 2,000 1,244E-03 0,03715322 ! chromosome segregation GO:0007059 83 57 2,000 1,244E-03 0,0366769 ! negative regulation of kinase activity GO:0033673 100 58 2,000 1,308E-03 0,03808702 ! positive regulation of cell size GO:0045793 20 15 1,000 1,385E-03 0,03982928 ! negative regulation of cell cycle process GO:0010948 24 15 1,000 1,385E-03 0,03933756 ! skin development GO:0043588 25 15 1,000 1,385E-03 0,03885783 ! regulation of survival gene product expression GO:0045884 20 15 1,000 1,385E-03 0,03838966 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 1,385E-03 0,03793264 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 1,385E-03 0,03748638 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 1,385E-03 0,03705049 ! regulation of homeostatic process GO:0032844 105 60 2,000 1,443E-03 0,03815302 ! negative regulation of transferase activity GO:0051348 105 61 2,000 1,514E-03 0,03956575 ! mitotic chromosome condensation GO:0007076 25 16 1,000 1,579E-03 0,04081813 ! antigen receptor-mediated signaling pathway GO:0050851 26 16 1,000 1,579E-03 0,0403646 ! organelle localization GO:0051640 96 62 2,000 1,587E-03 0,04010076 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 1,000 1,786E-03 0,04464491 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 1,786E-03 0,04416486 ! cell-substrate junction assembly GO:0007044 39 17 1,000 1,786E-03 0,04369502 ! actin filament bundle formation GO:0051017 26 17 1,000 1,786E-03 0,04323507 ! neuromuscular junction development GO:0007528 23 17 1,000 1,786E-03 0,04278471 ! nucleobase metabolic process GO:0009112 31 17 1,000 1,786E-03 0,04234363 ! regulation of caspase activity GO:0043281 97 65 2,000 1,818E-03 0,04266647 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 1,983E-03 0,04607674 ! positive regulation of angiogenesis GO:0045766 35 18 1,000 2,004E-03 0,04609689 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 1,000 2,004E-03 0,04564049 ! pancreas development GO:0031016 26 18 1,000 2,004E-03 0,04519303 ! gut development GO:0048565 26 18 1,000 2,004E-03 0,04475427 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 1,000 2,004E-03 0,04432394 ! negative regulation of T cell activation GO:0050868 25 18 1,000 2,004E-03 0,0439018 ! response to drug GO:0042493 108 69 2,000 2,158E-03 0,0468186 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 2,235E-03 0,04803438 ! response to alkaloid GO:0043279 32 19 1,000 2,235E-03 0,04758961 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 2,235E-03 0,04715301 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 2,235E-03 0,04672435 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 2,235E-03 0,04630341 ! apoptotic nuclear changes GO:0030262 24 19 1,000 2,235E-03 0,04588998 ! response to lipopolysaccharide GO:0032496 26 19 1,000 2,235E-03 0,04548388 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 2,235E-03 0,0450849 ! regulation of peptidase activity GO:0052547 106 72 2,000 2,437E-03 0,0487353 ! negative regulation of organelle organization GO:0010639 115 72 2,000 2,437E-03 0,04831517 ! chromosome condensation GO:0030261 31 20 1,000 2,477E-03 0,0486931 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 1,000 2,477E-03 0,04828045 ! determination of left/right symmetry GO:0007368 23 20 1,000 2,477E-03 0,04787473 ! DNA modification GO:0006304 28 20 1,000 2,477E-03 0,04747577 ! positive regulation of B cell activation GO:0050871 31 20 1,000 2,477E-03 0,04708341 ! mitochondrion organization GO:0007005 104 73 2,000 2,535E-03 0,04778158 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 1,000 2,731E-03 0,05107096 ! determination of bilateral symmetry GO:0009855 25 21 1,000 2,731E-03 0,0506591 GO:0009799|determination of symmetry, ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 2,731E-03 0,05025382 ! dendrite development GO:0016358 35 21 1,000 2,731E-03 0,04985498 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 2,731E-03 0,04946242 ! cellular response to extracellular stimulus GO:0031668 32 21 1,000 2,731E-03 0,049076 ! amine biosynthetic process GO:0009309 97 76 2,000 2,842E-03 0,05067417 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 2,997E-03 0,053026 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 1,000 2,997E-03 0,05262122 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! aspartate family amino acid metabolic process GO:0009066 24 22 1,000 2,997E-03 0,05222258 ! protein tetramerization GO:0051262 39 22 1,000 2,997E-03 0,05182992 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 3,275E-03 0,05620781 ! myelination GO:0042552 35 23 1,000 3,275E-03 0,05579145 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 3,275E-03 0,05538122 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 1,000 3,275E-03 0,05497698 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 1,000 3,275E-03 0,0545786 ! cellular response to oxidative stress GO:0034599 33 23 1,000 3,275E-03 0,05418594 ! response to molecule of bacterial origin GO:0002237 30 23 1,000 3,275E-03 0,0537989 ! insulin receptor signaling pathway GO:0008286 40 24 1,000 3,564E-03 0,05813422 ! fat cell differentiation GO:0045444 37 24 1,000 3,564E-03 0,05772482 ! biogenic amine metabolic process GO:0006576 121 83 2,000 3,647E-03 0,05865392 ! iron ion homeostasis GO:0055072 39 25 1,000 3,865E-03 0,06172511 ! positive regulation of nuclear division GO:0051785 39 25 1,000 3,865E-03 0,06129942 GO:0045840|positive regulation of mitosis, ! peptidyl-tyrosine modification GO:0018212 37 25 1,000 3,865E-03 0,06087956 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 3,865E-03 0,06046542 ! positive regulation of MAP kinase activity GO:0043406 121 85 2,000 3,9E-03 0,06060139 ! cell cycle arrest GO:0007050 150 86 2,000 4,03E-03 0,06220633 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 1,000 4,177E-03 0,0640408 ! negative regulation of protein modification process GO:0031400 50 26 1,000 4,177E-03 0,06361669 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 4,177E-03 0,06319816 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 4,5E-03 0,067646 ! serine family amino acid metabolic process GO:0009069 37 27 1,000 4,5E-03 0,06720674 ! protein modification by small protein conjugation GO:0032446 140 90 2,000 4,578E-03 0,0679257 ! cell junction assembly GO:0034329 56 28 1,000 4,835E-03 0,07127803 ! immune response-activating signal transduction GO:0002757 38 28 1,000 4,835E-03 0,07082403 GO:0002764|immune response-regulating signal transduction, ! ensheathment of neurons GO:0007272 43 28 1,000 4,835E-03 0,07037578 GO:0008366|axon ensheathment, ! regulation of B cell activation GO:0050864 42 28 1,000 4,835E-03 0,06993316 ! protein modification by small protein conjugation or removal GO:0070647 148 96 2,000 5,48E-03 0,07877674 ! regulation of microtubule-based process GO:0032886 58 30 1,000 5,537E-03 0,07910006 ! negative regulation of cell activation GO:0050866 44 30 1,000 5,537E-03 0,07861179 ! establishment of vesicle localization GO:0051650 45 30 1,000 5,537E-03 0,07812951 ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 2,000 5,64E-03 0,07909992 ! mammary gland development GO:0030879 57 31 1,000 5,905E-03 0,08230862 ! response to mechanical stimulus GO:0009612 43 31 1,000 5,905E-03 0,08181279 ! biogenic amine biosynthetic process GO:0042401 44 31 1,000 5,905E-03 0,08132289 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 2,000 5,969E-03 0,08171346 ! meiosis I GO:0007127 52 32 1,000 6,283E-03 0,08551345 ! peripheral nervous system development GO:0007422 53 32 1,000 6,283E-03 0,08501043 ! vesicle localization GO:0051648 47 32 1,000 6,283E-03 0,0845133 ! ear morphogenesis GO:0042471 42 33 1,000 6,673E-03 0,08922949 ! cell junction organization GO:0034330 63 33 1,000 6,673E-03 0,08871371 ! nucleus organization GO:0006997 49 33 1,000 6,673E-03 0,08820386 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 6,673E-03 0,08769984 ! cytokinesis GO:0000910 52 33 1,000 6,673E-03 0,08720154 ! cellular response to insulin stimulus GO:0032869 52 34 1,000 7,073E-03 0,09190862 ! keratinocyte differentiation GO:0030216 47 35 1,000 7,484E-03 0,09670025 ! regulation of action potential in neuron GO:0019228 54 35 1,000 7,484E-03 0,09616002 ! positive regulation of leukocyte proliferation GO:0070665 50 35 1,000 7,484E-03 0,0956258 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! response to reactive oxygen species GO:0000302 55 36 1,000 7,905E-03 0,1004516 ! regulation of T cell proliferation GO:0042129 58 38 1,000 8,779E-03 0,11094512 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 9,232E-03 0,11602631 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 9,232E-03 0,11539573 ! synapse organization GO:0050808 55 39 1,000 9,232E-03 0,11477197 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 9,694E-03 0,11987715 ! epidermal cell differentiation GO:0009913 53 40 1,000 9,694E-03 0,11923609 ! epithelial cell differentiation GO:0030855 55 41 1,000 0,01016732 0,1243874 ! glucose transport GO:0015758 52 41 1,000 0,01016732 0,12372927 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,01016732 0,12307806 ! biopolymer methylation GO:0043414 62 41 1,000 0,01016732 0,12243367 ! cellular component disassembly GO:0022411 64 42 1,000 0,0106503 0,12758166 ! hexose transport GO:0008645 54 42 1,000 0,0106503 0,12692062 GO:0015749|monosaccharide transport, ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,0106503 0,12626639 ! regulation of cell shape GO:0008360 78 42 1,000 0,0106503 0,12561887 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 0,01114327 0,1307628 ! activation of caspase activity GO:0006919 65 43 1,000 0,01114327 0,13009903 ! response to insulin stimulus GO:0032868 63 43 1,000 0,01114327 0,12944197 ! methylation GO:0032259 64 43 1,000 0,01114327 0,12879151 ! regulation of action potential GO:0001508 71 44 1,000 0,01164615 0,13393071 ! cellular amino acid biosynthetic process GO:0008652 51 44 1,000 0,01164615 0,13326439 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,01164615 0,13260467 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,01215887 0,13776058 ! protein amino acid autophosphorylation GO:0046777 80 45 1,000 0,01215887 0,13708528 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,01268135 0,14227852 ! response to UV GO:0009411 75 46 1,000 0,01268135 0,14158785 ! endocrine system development GO:0035270 83 47 1,000 0,01321351 0,14681673 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,01321351 0,14611088 ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,01375527 0,15137376 GO:0010952|positive regulation of peptidase activity, ! heart morphogenesis GO:0003007 65 48 1,000 0,01375527 0,15065294 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,01375527 0,14993894 ! ear development GO:0043583 72 50 1,000 0,0148673 0,16129618 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,0148673 0,16053892 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,0148673 0,15978874 ! positive regulation of growth GO:0045927 67 50 1,000 0,0148673 0,15904553 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 1,000 0,0148673 0,15830921 ! muscle fiber development GO:0048747 74 51 1,000 0,01543742 0,1636224 ! positive regulation of organelle organization GO:0010638 82 51 1,000 0,01543742 0,16287183 ! skeletal system morphogenesis GO:0048705 78 53 1,000 0,01660548 0,17439544 ! kidney development GO:0001822 90 53 1,000 0,01660548 0,17360274 ! regulation of mitosis GO:0007088 84 54 1,000 0,01720327 0,1790386 GO:0051783|regulation of nuclear division, ! cytokine-mediated signaling pathway GO:0019221 76 54 1,000 0,01720327 0,17823212 ! DNA catabolic process GO:0006308 67 54 1,000 0,01720327 0,17743287 ! detection of external stimulus GO:0009581 66 54 1,000 0,01720327 0,17664076 ! cellular amino acid catabolic process GO:0009063 74 54 1,000 0,01720327 0,17585569 ! DNA damage response, signal transduction GO:0042770 96 56 1,000 0,01842602 0,18752148 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,01845492 0,18698813 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,01845492 0,18616801 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,01845492 0,18535505 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,01845492 0,18454916 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,01845492 0,18375024 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,01845492 0,18295822 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,01845492 0,18217299 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,01845492 0,18139447 ! sleep GO:0030431 11 5 0,000 0,01845492 0,18062258 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,01845492 0,17985723 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,01845492 0,17909834 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,01845492 0,17834582 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,01845492 0,17759961 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,01845492 0,17685961 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,01845492 0,17612575 ! tongue development GO:0043586 6 5 0,000 0,01845492 0,17539796 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,01845492 0,17467616 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,01845492 0,17396027 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,01845492 0,17325023 ! cobalt ion transport GO:0006824 9 5 0,000 0,01845492 0,17254596 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,01845492 0,17184739 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,01845492 0,17115446 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,01845492 0,17046709 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,01845492 0,16978522 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,01845492 0,16910879 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,01845492 0,16843772 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,01845492 0,16777196 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,01845492 0,16711144 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,01845492 0,1664561 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,01845492 0,16580588 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,01845492 0,16516072 ! 2-oxoglutarate metabolic process GO:0006103 7 5 0,000 0,01845492 0,16452057 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,01845492 0,16388535 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,01845492 0,16325502 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,01845492 0,16262952 ! malate metabolic process GO:0006108 7 5 0,000 0,01845492 0,1620088 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,01845492 0,1613928 ! behavioral response to pain GO:0048266 7 5 0,000 0,01845492 0,16078146 ! clathrin coat assembly GO:0048268 11 5 0,000 0,01845492 0,16017474 ! phototransduction, visible light GO:0007603 6 5 0,000 0,01845492 0,15957258 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,01845492 0,15897493 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,01845492 0,15838174 ! mating behavior GO:0007617 6 5 0,000 0,01845492 0,15779296 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,01845492 0,15720854 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,01845492 0,15662844 ! rhythmic behavior GO:0007622 12 5 0,000 0,01845492 0,1560526 ! copulation GO:0007620 7 5 0,000 0,01845492 0,15548097 ! glial cell fate commitment GO:0021781 12 5 0,000 0,01845492 0,15491353 ! protein maturation by protein folding GO:0022417 12 5 0,000 0,01845492 0,1543502 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,01845492 0,15379096 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,01845492 0,15323576 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,01845492 0,15268455 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,01845492 0,1521373 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,01845492 0,15159395 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,01845492 0,15105447 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,01845492 0,15051882 ! response to protozoan GO:0001562 9 5 0,000 0,01845492 0,14998695 ! positive regulation of glycolysis GO:0045821 11 5 0,000 0,01845492 0,14945882 ! lymph vessel development GO:0001945 7 5 0,000 0,01845492 0,14893441 ! endochondral ossification GO:0001958 12 5 0,000 0,01845492 0,14841366 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,01845492 0,14789654 ! parathyroid gland development GO:0060017 8 5 0,000 0,01845492 0,14738301 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,01845492 0,14687303 ! anagen GO:0042640 6 5 0,000 0,01845492 0,14636657 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,01845492 0,14586359 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,01845492 0,14536406 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,01845492 0,14486794 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! nuclear migration GO:0007097 10 5 0,000 0,01845492 0,14437519 ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,01845492 0,14388578 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,01845492 0,14339968 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,01845492 0,14291686 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,01845492 0,14243727 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,01845492 0,14196089 GO:0046516|hypusine metabolic process, ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,01845492 0,14148769 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,01845492 0,14101763 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,01845492 0,14055068 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,01845492 0,14008682 ! ovulation GO:0030728 6 5 0,000 0,01845492 0,13962601 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,01845492 0,13916822 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,01845492 0,13871342 GO:0030033|microvillus assembly, ! valine metabolic process GO:0006573 8 5 0,000 0,01845492 0,13826158 ! response to pH GO:0009268 9 5 0,000 0,01845492 0,13781268 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,01845492 0,13736669 ! proline biosynthetic process GO:0006561 6 5 0,000 0,01845492 0,13692357 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,01845492 0,1364833 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,01845492 0,13604585 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,01845492 0,1356112 ! polyol catabolic process GO:0046174 7 5 0,000 0,01845492 0,13517932 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,01845492 0,13475018 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,01845492 0,13432375 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,01845492 0,13390002 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,01845492 0,13347895 ! nerve growth factor processing GO:0032455 7 5 0,000 0,01845492 0,13306052 ! urea metabolic process GO:0019627 6 5 0,000 0,01845492 0,13264471 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,01845492 0,13223148 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,01845492 0,13182083 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 0,000 0,01845492 0,13141271 ! neutrophil activation GO:0042119 5 5 0,000 0,01845492 0,13100712 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,01845492 0,13060402 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,01845492 0,13020339 ! response to food GO:0032094 5 5 0,000 0,01845492 0,12980522 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,01845492 0,12940947 GO:0043088|regulation of Cdc42 GTPase activity, ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 0,000 0,01845492 0,12901613 ! paraxial mesoderm development GO:0048339 9 5 0,000 0,01845492 0,12862517 ! forebrain neuron development GO:0021884 7 5 0,000 0,01845492 0,12823657 ! melanosome organization GO:0032438 7 5 0,000 0,01845492 0,12785032 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,01845492 0,12746638 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,01845492 0,12708475 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,01845492 0,12670539 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,01845492 0,12632829 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,01845492 0,12595343 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,01845492 0,12558079 ! nucleoside transport GO:0015858 6 5 0,000 0,01845492 0,12521034 ! nucleoside salvage GO:0043174 7 5 0,000 0,01845492 0,12484208 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,01845492 0,12447597 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,01845492 0,12411201 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,01845492 0,12375016 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,01845492 0,12339042 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,01845492 0,12303277 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,01845492 0,12267718 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,01845492 0,12232365 ! depyrimidination GO:0045008 8 5 0,000 0,01845492 0,12197214 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,01845492 0,12162265 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,01845492 0,12127516 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,01845492 0,12092965 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,01845492 0,1205861 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,01845492 0,12024449 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,01845492 0,11990482 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,01845492 0,11956706 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,01845492 0,1192312 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,01845492 0,11889722 ! monocyte differentiation GO:0030224 8 5 0,000 0,01845492 0,1185651 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,01845492 0,11823484 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,01845492 0,11790641 ! centrosome duplication GO:0051298 5 5 0,000 0,01845492 0,11757979 ! response to UV-C GO:0010225 6 5 0,000 0,01845492 0,11725499 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,01845492 0,11693197 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,01845492 0,11661073 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,01845492 0,11629125 ! regulation of dendrite development GO:0050773 12 5 0,000 0,01845492 0,11597351 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,01845492 0,11565751 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,01845492 0,11534322 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,01845492 0,11503064 GO:0002707|negative regulation of lymphocyte mediated immunity, ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,01845492 0,11471975 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,01845492 0,11441053 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,01845492 0,11410297 ! cranial nerve morphogenesis GO:0021602 6 5 0,000 0,01845492 0,11379707 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,01845492 0,1134928 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,01845492 0,11319015 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,01845492 0,11288911 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,01845492 0,11258967 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,01845492 0,11229181 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,01845492 0,11199553 ! neural tube patterning GO:0021532 6 5 0,000 0,01845492 0,11170081 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,01845492 0,11140763 ! histone demethylation GO:0016577 9 5 0,000 0,01845492 0,11111598 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,01845492 0,11082586 ! regulation of sterol transport GO:0032371 7 5 0,000 0,01845492 0,11053726 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,01845492 0,11025015 ! enteric nervous system development GO:0048484 8 5 0,000 0,01845492 0,10996452 ! establishment of planar polarity GO:0001736 6 5 0,000 0,01845492 0,10968038 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,01845492 0,1093977 ! muscle cell proliferation GO:0033002 8 5 0,000 0,01845492 0,10911647 ! transcription termination GO:0006353 8 5 0,000 0,01845492 0,10883668 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,01845492 0,10855833 ! positive regulation of pseudopodium assembly GO:0031274 13 5 0,000 0,01845492 0,10828139 GO:0031272|regulation of pseudopodium assembly, ! plasminogen activation GO:0031639 5 5 0,000 0,01845492 0,10800587 ! regulation of respiratory burst GO:0060263 8 5 0,000 0,01845492 0,10773174 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,01845492 0,107459 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,01845492 0,10718764 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,01845492 0,10691765 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,01845492 0,10664901 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,01845492 0,10638172 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,01845492 0,10611576 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,01845492 0,10585114 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,01845492 0,10558783 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,01845492 0,10532582 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,01845492 0,10506511 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,01845492 0,10480569 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,01845492 0,10454755 ! glial cell migration GO:0008347 10 5 0,000 0,01845492 0,10429068 ! determination of adult lifespan GO:0008340 8 5 0,000 0,01845492 0,10403506 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,01845492 0,1037807 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,01845492 0,10352758 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,01845492 0,10327568 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,01845492 0,10302501 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,01845492 0,10277556 ! neural plate development GO:0001840 6 5 0,000 0,01845492 0,10252731 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,01845492 0,10228026 ! regulation of sensory perception GO:0051931 6 5 0,000 0,01845492 0,10203439 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,01845492 0,1017897 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,01845492 0,10154619 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,01845492 0,10130383 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,01845492 0,10106263 ! sensory cilium assembly GO:0035058 6 5 0,000 0,01845492 0,10082258 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,01845492 0,10058366 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,01845492 0,10034588 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,01845492 0,10010921 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,01845492 0,09987366 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,01845492 0,09963922 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,01845492 0,09940587 ! organ regeneration GO:0031100 7 5 0,000 0,01845492 0,09917361 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,01845492 0,09894244 ! carnitine metabolic process GO:0009437 5 5 0,000 0,01845492 0,09871234 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,01845492 0,09848331 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,01845492 0,09825534 GO:0055081|anion homeostasis, ! carbohydrate transport GO:0008643 74 57 1,000 0,01905083 0,10119379 ! response to peptide hormone stimulus GO:0043434 84 57 1,000 0,01905083 0,10096062 ! actin filament organization GO:0007015 95 59 1,000 0,02032695 0,10747581 ! meiosis GO:0007126 96 61 1,000 0,02163792 0,11414498 GO:0051327|M phase of meiotic cell cycle, ! cell-matrix adhesion GO:0007160 114 61 1,000 0,02163792 0,11388378 ! urogenital system development GO:0001655 101 61 1,000 0,02163792 0,11362377 ! tRNA transcription GO:0009304 11 6 0,000 0,02210545 0,11581444 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,02210545 0,11555123 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,02210545 0,11528921 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,02210545 0,11502837 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,02210545 0,11476871 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,02210545 0,11451023 ! regulation of helicase activity GO:0051095 11 6 0,000 0,02210545 0,1142529 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,02210545 0,11399673 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,02210545 0,1137417 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,02210545 0,11348781 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,02210545 0,11323506 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,02210545 0,11298342 ! prostate gland development GO:0030850 9 6 0,000 0,02210545 0,11273291 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,02210545 0,1124835 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,02210545 0,11223519 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,02210545 0,11198797 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,02210545 0,11174185 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,02210545 0,1114968 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,02210545 0,11125282 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,02210545 0,11100991 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,02210545 0,11076806 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,02210545 0,11052726 ! regulation of protein export from nucleus GO:0046825 6 6 0,000 0,02210545 0,11028751 ! neuron adhesion GO:0007158 9 6 0,000 0,02210545 0,11004879 ! N-terminal protein amino acid acetylation GO:0006474 7 6 0,000 0,02210545 0,1098111 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,02210545 0,10957444 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,02210545 0,1093388 ! signal peptide processing GO:0006465 8 6 0,000 0,02210545 0,10910416 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,02210545 0,10887054 ! mRNA stabilization GO:0048255 15 6 0,000 0,02210545 0,10863791 GO:0043489|RNA stabilization, ! glucocorticoid receptor signaling pathway GO:0042921 9 6 0,000 0,02210545 0,10840627 GO:0031958|corticosteroid receptor signaling pathway, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,02210545 0,10817562 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,02210545 0,10794595 ! opsonization GO:0008228 8 6 0,000 0,02210545 0,10771725 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,02210545 0,10748951 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,02210545 0,10726274 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,02210545 0,10703693 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,02210545 0,10681206 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,02210545 0,10658814 ! photoreceptor cell development GO:0042461 10 6 0,000 0,02210545 0,10636515 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,02210545 0,10614309 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,02210545 0,10592196 ! mechanosensory behavior GO:0007638 8 6 0,000 0,02210545 0,10570175 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,02210545 0,10548245 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,02210545 0,10526406 ! response to interferon-gamma GO:0034341 12 6 0,000 0,02210545 0,10504657 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,02210545 0,10482998 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,02210545 0,10461428 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,02210545 0,10439947 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,02210545 0,10418553 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,02210545 0,10397248 ! cGMP-mediated signaling GO:0019934 10 6 0,000 0,02210545 0,10376029 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,02210545 0,10354896 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,02210545 0,1033385 ! thymic T cell selection GO:0045061 12 6 0,000 0,02210545 0,10312889 ! protein lipoylation GO:0009249 10 6 0,000 0,02210545 0,10292012 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,02210545 0,1027122 ! pigment granule organization GO:0048753 11 6 0,000 0,02210545 0,10250512 ! drug transport GO:0015893 6 6 0,000 0,02210545 0,10229887 ! cysteine metabolic process GO:0006534 7 6 0,000 0,02210545 0,10209345 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,02210545 0,10188886 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,02210545 0,10168508 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,02210545 0,10148212 ! histidine metabolic process GO:0006547 6 6 0,000 0,02210545 0,10127996 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,02210545 0,10107861 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,02210545 0,10087806 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,02210545 0,1006783 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,02210545 0,10047933 ! adenohypophysis development GO:0021984 10 6 0,000 0,02210545 0,10028114 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,02210545 0,10008374 ! hyperosmotic response GO:0006972 8 6 0,000 0,02210545 0,09988711 ! microtubule nucleation GO:0007020 10 6 0,000 0,02210545 0,09969126 ! ER overload response GO:0006983 7 6 0,000 0,02210545 0,09949617 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,02210545 0,09930184 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,02210545 0,09910827 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,02210545 0,09891545 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,02210545 0,09872338 ! positive regulation of muscle hypertrophy GO:0014742 9 6 0,000 0,02210545 0,09853206 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,02210545 0,09834147 ! response to dietary excess GO:0002021 7 6 0,000 0,02210545 0,09815162 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,02210545 0,09796251 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,02210545 0,09777412 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,02210545 0,09758645 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,02210545 0,0973995 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,02210545 0,09721327 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,02210545 0,09702775 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,02210545 0,09684293 ! neuron apoptosis GO:0051402 8 6 0,000 0,02210545 0,09665882 ! organic alcohol transport GO:0015850 9 6 0,000 0,02210545 0,09647541 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,02210545 0,09629269 ! T cell mediated immunity GO:0002456 12 6 0,000 0,02210545 0,09611066 ! male sex determination GO:0030238 9 6 0,000 0,02210545 0,09592932 ! carnitine transport GO:0015879 8 6 0,000 0,02210545 0,09574866 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,02210545 0,09556869 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,02210545 0,09538938 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,02210545 0,09521075 ! negative regulation of DNA recombination GO:0045910 9 6 0,000 0,02210545 0,09503279 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,02210545 0,09485549 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,02210545 0,09467885 ! parturition GO:0007567 12 6 0,000 0,02210545 0,09450286 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,02210545 0,09432753 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,02210545 0,09415285 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,02210545 0,09397882 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,02210545 0,09380543 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,02210545 0,09363267 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,02210545 0,09346055 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,02210545 0,09328907 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,02210545 0,09311821 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,02210545 0,09294797 ! macrophage differentiation GO:0030225 10 6 0,000 0,02210545 0,09277836 ! astrocyte development GO:0014002 14 6 0,000 0,02210545 0,09260936 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,02210545 0,09244098 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,02210545 0,09227321 ! interaction with symbiont GO:0051702 8 6 0,000 0,02210545 0,09210605 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,02210545 0,09193949 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,02210545 0,09177354 ! eating behavior GO:0042755 6 6 0,000 0,02210545 0,09160818 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,02210545 0,09144342 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,02210545 0,09127925 ! response to copper ion GO:0046688 9 6 0,000 0,02210545 0,09111566 ! DNA topological change GO:0006265 8 6 0,000 0,02210545 0,09095267 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,02210545 0,09079025 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 0,000 0,02210545 0,09062841 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,02210545 0,09046715 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,02210545 0,09030647 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,02210545 0,09014635 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,02210545 0,0899868 ! gas homeostasis GO:0033483 11 6 0,000 0,02210545 0,08982781 ! hair follicle maturation GO:0048820 7 6 0,000 0,02210545 0,08966938 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,02210545 0,08951151 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,02210545 0,0893542 ! Schwann cell development GO:0014044 14 6 0,000 0,02210545 0,08919744 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,02210545 0,08904123 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,02210545 0,08888556 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,02210545 0,08873044 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,02210545 0,08857585 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,02210545 0,08842181 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,02210545 0,0882683 ! histone ubiquitination GO:0016574 7 6 0,000 0,02210545 0,08811532 ! regulation of meiosis GO:0040020 10 6 0,000 0,02210545 0,08796287 GO:0051445|regulation of meiotic cell cycle, ! G2 phase GO:0051319 13 6 0,000 0,02210545 0,08781095 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,02210545 0,08765955 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,02210545 0,08750868 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,02210545 0,08735832 ! membrane to membrane docking GO:0022614 12 6 0,000 0,02210545 0,08720847 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,02210545 0,08705914 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,02210545 0,08691033 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,02210545 0,08676201 ! receptor internalization GO:0031623 9 6 0,000 0,02210545 0,08661421 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,02210545 0,08646691 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,02210545 0,0863201 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,02210545 0,0861738 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,02210545 0,08602799 ! protein deubiquitination GO:0016579 8 6 0,000 0,02210545 0,08588267 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,02210545 0,08573784 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,02210545 0,0855935 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,02210545 0,08544965 ! axonal fasciculation GO:0007413 9 6 0,000 0,02210545 0,08530628 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,02210545 0,08516338 ! thiamin metabolic process GO:0006772 6 6 0,000 0,02210545 0,08502097 ! midbrain development GO:0030901 6 6 0,000 0,02210545 0,08487903 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,02210545 0,08473757 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,02210545 0,08459657 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,02210545 0,08445605 ! progesterone metabolic process GO:0042448 8 6 0,000 0,02210545 0,08431599 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,02210545 0,08417639 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,02210545 0,08403726 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,02210545 0,08389858 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,02210545 0,08376036 ! adult feeding behavior GO:0008343 6 6 0,000 0,02210545 0,0836226 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,02210545 0,08348529 ! blastocyst growth GO:0001832 15 6 0,000 0,02210545 0,08334843 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,02210545 0,08321201 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,02210545 0,08307605 ! catecholamine transport GO:0051937 7 6 0,000 0,02210545 0,08294052 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,02210545 0,08280544 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,02210545 0,0826708 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,02210545 0,08253659 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,02210545 0,08240282 ! protein prenylation GO:0018342 10 6 0,000 0,02210545 0,08226948 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,02210545 0,08213658 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,02210545 0,0820041 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,02210545 0,08187205 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,02210545 0,08174042 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,02210545 0,08160921 ! amine catabolic process GO:0009310 90 62 1,000 0,02230629 0,08221872 ! negative regulation of cell growth GO:0030308 106 62 1,000 0,02230629 0,08208717 ! meiotic cell cycle GO:0051321 97 62 1,000 0,02230629 0,08195604 ! negative regulation of cell size GO:0045792 108 64 1,000 0,02366848 0,08682217 ! activation of immune response GO:0002253 83 65 1,000 0,02436215 0,08922442 ! protein oligomerization GO:0051259 100 65 1,000 0,02436215 0,08908257 ! cell-substrate adhesion GO:0031589 121 66 1,000 0,0250641 0,09150387 ! axon guidance GO:0007411 99 66 1,000 0,0250641 0,09135886 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,02574262 0,09368359 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 0,000 0,02574262 0,09353559 GO:0016446|somatic hypermutation of immunoglobulin genes, ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,02574262 0,09338805 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,02574262 0,09324099 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,02574262 0,09309438 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,02574262 0,09294824 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,02574262 0,09280255 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,02574262 0,09265732 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,02574262 0,09251254 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,02574262 0,09236822 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,02574262 0,09222434 ! reproductive behavior GO:0019098 12 7 0,000 0,02574262 0,09208091 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,02574262 0,09193793 ! regulation of lipid kinase activity GO:0043550 12 7 0,000 0,02574262 0,09179539 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,02574262 0,09165329 ! regulation of smooth muscle cell migration GO:0014910 19 7 0,000 0,02574262 0,09151163 ! oligopeptide transport GO:0006857 11 7 0,000 0,02574262 0,09137041 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,02574262 0,09122962 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,02574262 0,09108927 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,02574262 0,09094935 ! RNA methylation GO:0001510 11 7 0,000 0,02574262 0,09080986 ! pericardium development GO:0060039 8 7 0,000 0,02574262 0,09067079 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,02574262 0,09053215 ! fibril organization GO:0043206 13 7 0,000 0,02574262 0,09039393 ! oxaloacetate metabolic process GO:0006107 9 7 0,000 0,02574262 0,09025614 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,02574262 0,09011876 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,02574262 0,0899818 ! lipoprotein transport GO:0042953 9 7 0,000 0,02574262 0,08984526 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,02574262 0,08970913 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,02574262 0,08957341 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,02574262 0,08943811 ! estrogen metabolic process GO:0008210 14 7 0,000 0,02574262 0,08930321 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,02574262 0,08916871 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,02574262 0,08903463 ! chemosensory behavior GO:0007635 9 7 0,000 0,02574262 0,08890094 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,02574262 0,08876766 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,02574262 0,08863477 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,02574262 0,08850228 ! leukocyte degranulation GO:0043299 10 7 0,000 0,02574262 0,08837019 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,02574262 0,08823849 ! reflex GO:0060004 12 7 0,000 0,02574262 0,08810718 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,02574262 0,08797627 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,02574262 0,08784574 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,02574262 0,08771559 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,02574262 0,08758584 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,02574262 0,08745646 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,02574262 0,08732747 ! spinal cord patterning GO:0021511 7 7 0,000 0,02574262 0,08719886 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,02574262 0,08707063 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,02574262 0,08694277 ! adrenal gland development GO:0030325 17 7 0,000 0,02574262 0,08681529 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,02574262 0,08668818 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,02574262 0,08656144 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,02574262 0,08643508 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,02574262 0,08630908 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,02574262 0,08618344 ! endosome organization GO:0007032 10 7 0,000 0,02574262 0,08605818 ! thyroid hormone generation GO:0006590 11 7 0,000 0,02574262 0,08593328 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,02574262 0,08580873 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,02574262 0,08568455 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,02574262 0,08556073 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,02574262 0,08543727 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,02574262 0,08531416 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,02574262 0,08519141 ! galactose metabolic process GO:0006012 10 7 0,000 0,02574262 0,085069 ! vesicle fusion GO:0006906 15 7 0,000 0,02574262 0,08494695 ! intracellular pH reduction GO:0051452 10 7 0,000 0,02574262 0,08482525 GO:0045851|pH reduction, ! organ growth GO:0035265 11 7 0,000 0,02574262 0,0847039 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,02574262 0,0845829 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,02574262 0,08446223 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,02574262 0,08434192 ! retinol metabolic process GO:0042572 9 7 0,000 0,02574262 0,08422194 ! behavioral fear response GO:0001662 13 7 0,000 0,02574262 0,08410231 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,02574262 0,08398302 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,02574262 0,08386406 ! rRNA modification GO:0000154 12 7 0,000 0,02574262 0,08374544 ! protein heterooligomerization GO:0051291 10 7 0,000 0,02574262 0,08362716 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,02574262 0,08350921 ! response to UV-B GO:0010224 11 7 0,000 0,02574262 0,08339159 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,02574262 0,0832743 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,02574262 0,08315734 ! intermediate filament organization GO:0045109 11 7 0,000 0,02574262 0,08304071 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,02574262 0,08292441 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,02574262 0,08280843 ! fibrinolysis GO:0042730 9 7 0,000 0,02574262 0,08269277 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,02574262 0,08257744 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,02574262 0,08246243 ! B cell lineage commitment GO:0002326 17 7 0,000 0,02574262 0,08234774 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,02574262 0,08223337 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,02574262 0,08211932 ! response to tropane GO:0014073 13 7 0,000 0,02574262 0,08200558 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,02574262 0,08189215 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,02574262 0,08177904 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,02574262 0,08166624 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,02574262 0,08155376 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,02574262 0,08144158 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,02574262 0,08132971 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,02574262 0,08121814 ! mast cell activation GO:0045576 9 7 0,000 0,02574262 0,08110689 ! multicellular organismal aging GO:0010259 11 7 0,000 0,02574262 0,08099593 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,02574262 0,08088528 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,02574262 0,08077493 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,02574262 0,08066489 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,02574262 0,08055514 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,02574262 0,08044569 ! establishment of nucleus localization GO:0040023 13 7 0,000 0,02574262 0,08033654 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,02574262 0,08022768 ! T cell lineage commitment GO:0002360 12 7 0,000 0,02574262 0,08011912 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,02574262 0,08001085 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,02574262 0,07990287 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,02574262 0,07979518 ! regulation of lipid transport GO:0032368 13 7 0,000 0,02574262 0,07968779 ! response to tumor cell GO:0002347 12 7 0,000 0,02574262 0,07958068 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,02574262 0,07947386 ! neuroblast proliferation GO:0007405 13 7 0,000 0,02574262 0,07936733 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,02574262 0,07926108 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,02574262 0,07915512 ! diuresis GO:0030146 12 7 0,000 0,02574262 0,07904943 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,02574262 0,07894404 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,02574262 0,07883892 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,02574262 0,07873408 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,02574262 0,07862952 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,02574262 0,07852523 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,02574262 0,07842123 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,02574262 0,0783175 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,02574262 0,07821404 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,02574262 0,07811085 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,02574262 0,07800794 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,02574262 0,0779053 ! lymph node development GO:0048535 9 7 0,000 0,02574262 0,07780293 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,02574262 0,07770082 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,02574262 0,07759899 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,02574262 0,07749742 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,02574262 0,07739611 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,02574262 0,07729507 ! ATP catabolic process GO:0006200 10 7 0,000 0,02574262 0,0771943 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,02574262 0,07709378 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,02574262 0,07699353 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,02574262 0,07689354 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,02574262 0,07679381 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,02574262 0,07669433 ! muscle adaptation GO:0043500 12 7 0,000 0,02574262 0,07659512 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,02574262 0,07649616 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,02574262 0,07639745 ! retina homeostasis GO:0001895 9 7 0,000 0,02574262 0,076299 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,02574262 0,07620081 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,02574262 0,07610286 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,02574262 0,07600517 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,02574262 0,07590773 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,02574262 0,07581053 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,02574262 0,07571359 ! intracellular protein transmembrane transport GO:0065002 102 68 1,000 0,02649261 0,07781994 ! phosphoinositide-mediated signaling GO:0048015 109 71 1,000 0,02869584 0,08418422 ! steroid biosynthetic process GO:0006694 94 71 1,000 0,02869584 0,08407697 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,02936647 0,08593241 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,02936647 0,08582322 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! axon extension GO:0048675 11 8 0,000 0,02936647 0,08571431 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 0,000 0,02936647 0,08560567 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,02936647 0,08549731 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,02936647 0,08538922 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,02936647 0,08528141 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,02936647 0,08517387 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,02936647 0,08506659 ! phosphate transport GO:0006817 10 8 0,000 0,02936647 0,08495959 ! N-glycan processing GO:0006491 12 8 0,000 0,02936647 0,08485286 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,02936647 0,08474639 ! UTP metabolic process GO:0046051 8 8 0,000 0,02936647 0,08464019 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,02936647 0,08453426 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,02936647 0,08442859 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,02936647 0,08432319 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,02936647 0,08421805 ! succinate metabolic process GO:0006105 14 8 0,000 0,02936647 0,08411317 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,02936647 0,08400855 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,02936647 0,08390419 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,02936647 0,08380009 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,02936647 0,08369625 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,02936647 0,08359267 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,02936647 0,08348934 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,02936647 0,08338627 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,02936647 0,08328345 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,02936647 0,08318088 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,02936647 0,08307857 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,02936647 0,0829765 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,02936647 0,08287469 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,02936647 0,08277313 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,02936647 0,08267182 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 0,000 0,02936647 0,08257075 ! astrocyte differentiation GO:0048708 16 8 0,000 0,02936647 0,08246993 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,02936647 0,08236936 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,02936647 0,08226903 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,02936647 0,08216895 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,02936647 0,08206911 GO:0006559|L-phenylalanine catabolic process, ! melanin metabolic process GO:0006582 12 8 0,000 0,02936647 0,08196951 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,02936647 0,08187015 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,02936647 0,08177104 ! positive regulation of endothelial cell migration GO:0010595 18 8 0,000 0,02936647 0,08167216 ! macrophage activation GO:0042116 12 8 0,000 0,02936647 0,08157352 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,02936647 0,08147512 ! regulation of muscle hypertrophy GO:0014743 11 8 0,000 0,02936647 0,08137696 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! multicellular organism growth GO:0035264 14 8 0,000 0,02936647 0,08127903 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,02936647 0,08118134 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,02936647 0,08108388 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,02936647 0,08098666 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,02936647 0,08088967 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,02936647 0,08079291 ! ruffle organization GO:0031529 11 8 0,000 0,02936647 0,08069639 ! osteoblast development GO:0002076 13 8 0,000 0,02936647 0,08060009 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,02936647 0,08050402 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,02936647 0,08040818 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,02936647 0,08031257 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,02936647 0,08021719 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,02936647 0,08012203 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,02936647 0,0800271 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,02936647 0,0799324 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,02936647 0,07983791 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,02936647 0,07974365 ! regulation of gliogenesis GO:0014013 20 8 0,000 0,02936647 0,07964962 GO:0045685|regulation of glial cell differentiation, ! brain morphogenesis GO:0048854 20 8 0,000 0,02936647 0,0795558 ! oligodendrocyte development GO:0014003 8 8 0,000 0,02936647 0,07946221 ! segment specification GO:0007379 10 8 0,000 0,02936647 0,07936883 ! cellular extravasation GO:0045123 11 8 0,000 0,02936647 0,07927567 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,02936647 0,07918274 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,02936647 0,07909002 ! snRNA metabolic process GO:0016073 10 8 0,000 0,02936647 0,07899751 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,02936647 0,07890523 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,02936647 0,07881316 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,02936647 0,0787213 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,02936647 0,07862966 ! nucleosome disassembly GO:0006337 12 8 0,000 0,02936647 0,07853823 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,02936647 0,07844701 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,02936647 0,078356 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,02936647 0,07826521 ! icosanoid secretion GO:0032309 12 8 0,000 0,02936647 0,07817462 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,02936647 0,07808425 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,02936647 0,07799408 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,02936647 0,07790412 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,02936647 0,07781437 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,02936647 0,07772483 ! retinal ganglion cell axon guidance GO:0031290 10 8 0,000 0,02936647 0,07763549 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,02936647 0,07754635 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,02936647 0,07745743 ! sterol catabolic process GO:0016127 9 8 0,000 0,02936647 0,0773687 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,02936647 0,07728018 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,02936647 0,07719186 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,02936647 0,07710374 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,02936647 0,07701582 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,02936647 0,0769281 ! prophase GO:0051324 11 8 0,000 0,02936647 0,07684059 ! S phase GO:0051320 8 8 0,000 0,02936647 0,07675327 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,02936647 0,07666615 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,02936647 0,07657922 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,02936647 0,0764925 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,02936647 0,07640597 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,02936647 0,07631963 ! hormone catabolic process GO:0042447 13 8 0,000 0,02936647 0,07623349 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,02936647 0,07614755 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,02936647 0,0760618 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,02936647 0,07597624 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,02936647 0,07589087 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,02936647 0,0758057 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,02936647 0,07572071 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,02936647 0,07563592 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,02936647 0,07555131 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,02936647 0,0754669 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,02936647 0,07538267 ! lamellipodium assembly GO:0030032 9 8 0,000 0,02936647 0,07529863 ! regulation of embryonic development GO:0045995 16 8 0,000 0,02936647 0,07521478 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,02936647 0,07513112 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,02936647 0,07504764 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,02936647 0,07496435 ! cellular response to hormone stimulus GO:0032870 109 74 1,000 0,03096999 0,07897004 ! positive regulation of lymphocyte activation GO:0051251 108 74 1,000 0,03096999 0,07888259 ! negative regulation of growth GO:0045926 123 75 1,000 0,03174349 0,08076331 ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,03252461 0,08265923 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 0,000 0,03297704 0,08371655 ! regulation of developmental growth GO:0048638 13 9 0,000 0,03297704 0,08362425 ! positive regulation of glucose metabolic process GO:0010907 15 9 0,000 0,03297704 0,08353215 ! telencephalon cell migration GO:0022029 16 9 0,000 0,03297704 0,08344026 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,03297704 0,08334857 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,03297704 0,08325708 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,03297704 0,08316579 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,03297704 0,08307469 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,03297704 0,0829838 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,03297704 0,08289311 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,03297704 0,08280262 ! GTP metabolic process GO:0046039 9 9 0,000 0,03297704 0,08271232 ! elastic fiber assembly GO:0048251 13 9 0,000 0,03297704 0,08262222 ! social behavior GO:0035176 14 9 0,000 0,03297704 0,08253231 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,03297704 0,0824426 ! artery development GO:0060840 19 9 0,000 0,03297704 0,08235309 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,03297704 0,08226377 ! regulation of glycolysis GO:0006110 15 9 0,000 0,03297704 0,08217464 ! response to pain GO:0048265 16 9 0,000 0,03297704 0,08208571 ! protein complex disassembly GO:0043241 17 9 0,000 0,03297704 0,08199697 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,03297704 0,08190842 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,03297704 0,08182006 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,03297704 0,08173189 ! lung alveolus development GO:0048286 17 9 0,000 0,03297704 0,08164391 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,03297704 0,08155613 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,03297704 0,08146852 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,03297704 0,08138111 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,03297704 0,08129389 ! ventral spinal cord development GO:0021517 11 9 0,000 0,03297704 0,08120685 ! protein targeting to ER GO:0045047 19 9 0,000 0,03297704 0,08112 ! T cell selection GO:0045058 18 9 0,000 0,03297704 0,08103333 ! endoderm development GO:0007492 12 9 0,000 0,03297704 0,08094685 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,03297704 0,08086055 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,03297704 0,08077444 ! arginine catabolic process GO:0006527 10 9 0,000 0,03297704 0,08068851 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,03297704 0,08060276 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,03297704 0,08051719 GO:0010833|telomere maintenance via telomere lengthening, ! phosphagen metabolic process GO:0006599 12 9 0,000 0,03297704 0,08043181 GO:0006600|creatine metabolic process, ! V(D)J recombination GO:0033151 12 9 0,000 0,03297704 0,08034661 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,03297704 0,08026158 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,03297704 0,08017674 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,03297704 0,08009208 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,03297704 0,08000759 ! mannose metabolic process GO:0006013 9 9 0,000 0,03297704 0,07992328 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,03297704 0,07983915 ! receptor clustering GO:0043113 15 9 0,000 0,03297704 0,0797552 ! epithelial cell development GO:0002064 10 9 0,000 0,03297704 0,07967142 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,03297704 0,07958782 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,03297704 0,0795044 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,03297704 0,07942115 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,03297704 0,07933807 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,03297704 0,07925517 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,03297704 0,07917244 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,03297704 0,07908988 ! positive regulation of phagocytosis GO:0050766 11 9 0,000 0,03297704 0,0790075 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,03297704 0,07892528 ! blastoderm segmentation GO:0007350 11 9 0,000 0,03297704 0,07884324 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,03297704 0,07876137 ! DNA ligation GO:0006266 14 9 0,000 0,03297704 0,07867966 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,03297704 0,07859813 ! response to amine stimulus GO:0014075 13 9 0,000 0,03297704 0,07851677 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,03297704 0,07843557 ! erythrocyte development GO:0048821 11 9 0,000 0,03297704 0,07835454 ! renal water homeostasis GO:0003091 14 9 0,000 0,03297704 0,07827368 ! postreplication repair GO:0006301 11 9 0,000 0,03297704 0,07819299 ! mRNA cleavage GO:0006379 13 9 0,000 0,03297704 0,07811246 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,03297704 0,0780321 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,03297704 0,0779519 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,03297704 0,07787187 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,03297704 0,077792 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,03297704 0,07771229 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,03297704 0,07763275 ! acid secretion GO:0046717 14 9 0,000 0,03297704 0,07755337 ! musculoskeletal movement GO:0050881 11 9 0,000 0,03297704 0,07747415 GO:0050879|multicellular organismal movement, ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,03297704 0,0773951 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,03297704 0,0773162 ! purine base metabolic process GO:0006144 18 9 0,000 0,03297704 0,07723747 ! oocyte differentiation GO:0009994 12 9 0,000 0,03297704 0,0771589 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,03297704 0,07708048 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,03297704 0,07700223 ! spleen development GO:0048536 15 9 0,000 0,03297704 0,07692413 ! negative regulation of BMP signaling pathway GO:0030514 13 9 0,000 0,03297704 0,0768462 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,03297704 0,07676842 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,03297704 0,0766908 ! detection of calcium ion GO:0005513 13 9 0,000 0,03297704 0,07661333 ! blastocyst formation GO:0001825 12 9 0,000 0,03297704 0,07653602 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,03297704 0,07645887 ! regulation of muscle adaptation GO:0043502 12 9 0,000 0,03297704 0,07638187 ! regulation of amino acid transport GO:0051955 11 9 0,000 0,03297704 0,07630503 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,03297704 0,07622834 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,03297704 0,0761518 ! prepulse inhibition GO:0060134 14 9 0,000 0,03297704 0,07607542 ! embryonic placenta development GO:0001892 12 9 0,000 0,03297704 0,07599919 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,03297704 0,07592312 ! insulin secretion GO:0030073 17 9 0,000 0,03297704 0,0758472 ! sequestering of metal ion GO:0051238 11 9 0,000 0,03297704 0,07577143 ! response to nicotine GO:0035094 16 9 0,000 0,03297704 0,0756958 ! establishment of cell polarity GO:0030010 12 9 0,000 0,03297704 0,07562034 ! nucleus localization GO:0051647 15 9 0,000 0,03297704 0,07554502 ! regulation of synapse organization GO:0050807 12 9 0,000 0,03297704 0,07546985 ! localization within membrane GO:0051668 15 9 0,000 0,03297704 0,07539483 ! gland development GO:0048732 148 77 1,000 0,03331328 0,07608792 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,03331328 0,07601243 ! nitrogen compound catabolic process GO:0044270 114 78 1,000 0,03410943 0,07775192 ! mRNA transport GO:0051028 121 81 1,000 0,03654215 0,08321479 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,03654215 0,08313248 ! positive regulation of cell activation GO:0050867 120 81 1,000 0,03654215 0,08305034 GO:0002696|positive regulation of leukocyte activation, ! negative regulation of muscle development GO:0048635 12 10 0,000 0,03657439 0,08304156 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,03657439 0,08295967 ! neuron fate specification GO:0048665 11 10 0,000 0,03657439 0,08287793 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,03657439 0,08279636 ! cortical actin cytoskeleton organization GO:0030866 19 10 0,000 0,03657439 0,08271495 ! thyroid gland development GO:0030878 19 10 0,000 0,03657439 0,08263369 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,03657439 0,0825526 ! synapsis GO:0007129 13 10 0,000 0,03657439 0,08247167 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,03657439 0,08239089 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,03657439 0,08231027 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,03657439 0,08222982 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,03657439 0,08214951 ! sulfate transport GO:0008272 12 10 0,000 0,03657439 0,08206937 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,03657439 0,08198938 GO:0048200|Golgi transport vesicle coating, ! regulation of cell projection assembly GO:0060491 20 10 0,000 0,03657439 0,08190954 ! androgen metabolic process GO:0008209 13 10 0,000 0,03657439 0,08182986 ! phospholipid efflux GO:0033700 16 10 0,000 0,03657439 0,08175034 ! hippocampus development GO:0021766 19 10 0,000 0,03657439 0,08167097 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,03657439 0,08159176 ! blood vessel remodeling GO:0001974 21 10 0,000 0,03657439 0,08151269 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,03657439 0,08143379 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,03657439 0,08135503 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,03657439 0,08127643 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,03657439 0,08119797 ! pathogenesis GO:0009405 13 10 0,000 0,03657439 0,08111967 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,03657439 0,08104152 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,03657439 0,08096352 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,03657439 0,08088567 ! peptide or protein amino-terminal blocking GO:0018409 14 10 0,000 0,03657439 0,08080797 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,03657439 0,08073042 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,03657439 0,08065302 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,03657439 0,08057577 ! glucan biosynthetic process GO:0009250 13 10 0,000 0,03657439 0,08049866 GO:0005978|glycogen biosynthetic process, ! reverse cholesterol transport GO:0043691 16 10 0,000 0,03657439 0,0804217 ! response to X-ray GO:0010165 16 10 0,000 0,03657439 0,08034489 ! B cell proliferation GO:0042100 14 10 0,000 0,03657439 0,08026823 ! nucleobase biosynthetic process GO:0046112 21 10 0,000 0,03657439 0,08019171 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,03657439 0,08011533 ! forebrain cell migration GO:0021885 17 10 0,000 0,03657439 0,08003911 ! lipid digestion GO:0044241 15 10 0,000 0,03657439 0,07996302 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,03657439 0,07988709 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,03657439 0,07981129 ! UV protection GO:0009650 14 10 0,000 0,03657439 0,07973564 ! entry into host cell GO:0030260 20 10 0,000 0,03657439 0,07966013 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,03657439 0,07958477 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,03657439 0,07950955 ! negative regulation of ossification GO:0030279 19 10 0,000 0,03657439 0,07943447 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,03657439 0,07935953 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,03657439 0,07928473 ! regulation of bone resorption GO:0045124 24 10 0,000 0,03657439 0,07921008 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,03657439 0,07913556 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,03657439 0,07906119 ! regulation of organ growth GO:0046620 11 10 0,000 0,03657439 0,07898695 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,03657439 0,07891285 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,03657439 0,07883889 ! embryonic axis specification GO:0000578 12 10 0,000 0,03657439 0,07876508 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,03657439 0,07869139 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,03657439 0,07861785 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,03657439 0,07854445 ! cranial nerve development GO:0021545 12 10 0,000 0,03657439 0,07847118 ! fucose catabolic process GO:0019317 16 10 0,000 0,03657439 0,07839804 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,03657439 0,07832505 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,03657439 0,07825219 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,03657439 0,07817946 ! zymogen activation GO:0031638 14 10 0,000 0,03657439 0,07810687 ! salivary gland development GO:0007431 22 10 0,000 0,03657439 0,07803442 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,03657439 0,0779621 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,03657439 0,07788991 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,03657439 0,07781785 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,03657439 0,07774593 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,03657439 0,07767415 ! nitric oxide mediated signal transduction GO:0007263 17 10 0,000 0,03657439 0,07760249 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,03657439 0,07753097 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,03657439 0,07745958 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,03657439 0,07738832 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 0,000 0,03657439 0,07731719 GO:0043470|regulation of carbohydrate catabolic process, ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,03657439 0,07724619 ! detection of bacterium GO:0016045 10 10 0,000 0,03657439 0,07717532 ! embryonic gut development GO:0048566 11 10 0,000 0,03657439 0,07710458 ! activation of innate immune response GO:0002218 10 10 0,000 0,03657439 0,07703398 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,03657439 0,0769635 ! cardiac cell differentiation GO:0035051 16 10 0,000 0,03657439 0,07689315 ! developmental induction GO:0031128 13 10 0,000 0,03657439 0,07682292 GO:0045168|cell-cell signaling involved in cell fate specification, ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,03657439 0,07675283 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,03657439 0,07668286 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,03657439 0,07661302 ! detection of stimulus GO:0051606 108 82 1,000 0,0373676 0,07820334 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,03820021 0,07987317 ! regulation of DNA metabolic process GO:0051052 135 85 1,000 0,03988668 0,08332368 ! Golgi vesicle transport GO:0048193 138 85 1,000 0,03988668 0,08324807 ! transcription initiation GO:0006352 118 85 1,000 0,03988668 0,08317259 ! regulation of membrane potential GO:0042391 128 85 1,000 0,03988668 0,08309725 ! rRNA transcription GO:0009303 17 11 0,000 0,04015856 0,08358796 ! respiratory burst GO:0045730 14 11 0,000 0,04015856 0,08351239 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,04015856 0,08343694 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,04015856 0,08336164 ! cortical cytoskeleton organization GO:0030865 20 11 0,000 0,04015856 0,08328647 ! virus-host interaction GO:0019048 17 11 0,000 0,04015856 0,08321144 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,04015856 0,08313654 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,04015856 0,08306178 GO:0000725|recombinational repair, ! filopodium assembly GO:0046847 19 11 0,000 0,04015856 0,08298715 ! Golgi vesicle budding GO:0048194 17 11 0,000 0,04015856 0,08291266 ! RNA polyadenylation GO:0043631 19 11 0,000 0,04015856 0,08283829 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,04015856 0,08276407 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,04015856 0,08268997 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,04015856 0,08261601 ! T cell proliferation GO:0042098 20 11 0,000 0,04015856 0,08254218 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,04015856 0,08246848 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,04015856 0,08239491 ! bone resorption GO:0045453 16 11 0,000 0,04015856 0,08232148 ! regulated secretory pathway GO:0045055 14 11 0,000 0,04015856 0,08224817 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,04015856 0,082175 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,04015856 0,08210195 ! regulation of mRNA processing GO:0050684 18 11 0,000 0,04015856 0,08202904 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,04015856 0,08195625 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,04015856 0,0818836 ! syncytium formation GO:0006949 15 11 0,000 0,04015856 0,08181107 ! plasma membrane organization GO:0007009 18 11 0,000 0,04015856 0,08173867 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,04015856 0,0816664 ! mitotic spindle organization GO:0007052 15 11 0,000 0,04015856 0,08159426 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,04015856 0,08152224 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,04015856 0,08145035 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,04015856 0,08137859 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,04015856 0,08130695 ! adult heart development GO:0007512 11 11 0,000 0,04015856 0,08123544 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,04015856 0,08116406 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,04015856 0,0810928 ! temperature homeostasis GO:0001659 16 11 0,000 0,04015856 0,08102166 ! L-glutamate transport GO:0015813 16 11 0,000 0,04015856 0,08095066 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,04015856 0,08087977 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,04015856 0,08080901 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,04015856 0,08073837 ! stem cell development GO:0048864 29 11 0,000 0,04015856 0,08066786 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,04015856 0,08059747 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,04015856 0,0805272 ! regulation of phagocytosis GO:0050764 14 11 0,000 0,04015856 0,08045705 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,04015856 0,08038703 ! vasoconstriction GO:0042310 15 11 0,000 0,04015856 0,08031713 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,04015856 0,08024735 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 0,000 0,04015856 0,08017769 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,04015856 0,08010815 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,04015856 0,08003873 ! ribosome assembly GO:0042255 13 11 0,000 0,04015856 0,07996944 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,04015856 0,07990026 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,04015856 0,0798312 ! chromatin silencing GO:0006342 19 11 0,000 0,04015856 0,07976226 ! nucleosome positioning GO:0016584 13 11 0,000 0,04015856 0,07969344 ! T cell homeostasis GO:0043029 20 11 0,000 0,04015856 0,07962474 ! regulation of isotype switching GO:0045191 19 11 0,000 0,04015856 0,07955616 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,04015856 0,07948769 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,04015856 0,07941934 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,04015856 0,07935112 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,04015856 0,079283 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,04015856 0,07921501 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 0,000 0,04015856 0,07914713 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! oxygen transport GO:0015671 15 11 0,000 0,04015856 0,07907936 ! male genitalia development GO:0030539 13 11 0,000 0,04015856 0,07901172 ! cholesterol efflux GO:0033344 19 11 0,000 0,04015856 0,07894419 ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,04015856 0,07887677 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,04015856 0,07880947 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,04015856 0,07874228 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,04015856 0,07867521 ! defense response to fungus GO:0050832 12 11 0,000 0,04015856 0,07860825 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,04015856 0,07854141 ! lysogeny GO:0030069 18 11 0,000 0,04015856 0,07847468 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,04015856 0,07840806 ! acrosome reaction GO:0007340 13 11 0,000 0,04015856 0,07834156 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,04015856 0,07827517 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,04074041 0,07934204 ! skeletal muscle tissue development GO:0007519 123 87 1,000 0,04160106 0,08094962 GO:0060538|skeletal muscle organ development, ! interphase GO:0051325 159 88 1,000 0,04246857 0,0825678 ! carboxylic acid catabolic process GO:0046395 122 88 1,000 0,04246857 0,08249806 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 1,000 0,04246857 0,08242844 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! protein processing GO:0016485 114 88 1,000 0,04246857 0,08235894 ! regulation of T cell activation GO:0050863 128 89 1,000 0,04334286 0,08398364 ! lactation GO:0007595 20 12 0,000 0,04372961 0,0846617 ! reproductive cellular process GO:0048610 14 12 0,000 0,04372961 0,08459049 ! tRNA modification GO:0006400 14 12 0,000 0,04372961 0,08451941 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,04372961 0,08444844 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,04372961 0,0843776 ! positive regulation of cellular catabolic process GO:0031331 22 12 0,000 0,04372961 0,08430687 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,04372961 0,08423626 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,04372961 0,08416577 ! non-recombinational repair GO:0000726 19 12 0,000 0,04372961 0,0840954 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,04372961 0,08402514 ! peroxisomal transport GO:0043574 21 12 0,000 0,04372961 0,08395501 ! cartilage condensation GO:0001502 18 12 0,000 0,04372961 0,08388499 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,04372961 0,08381508 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,04372961 0,08374529 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,04372961 0,08367562 ! palate development GO:0060021 15 12 0,000 0,04372961 0,08360607 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,04372961 0,08353663 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,04372961 0,0834673 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,04372961 0,08339809 ! arginine metabolic process GO:0006525 13 12 0,000 0,04372961 0,083329 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,04372961 0,08326001 ! methionine metabolic process GO:0006555 13 12 0,000 0,04372961 0,08319115 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,04372961 0,08312239 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,04372961 0,08305375 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,04372961 0,08298523 ! monoamine transport GO:0015844 13 12 0,000 0,04372961 0,08291682 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,04372961 0,08284851 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 0,000 0,04372961 0,08278033 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! neutral amino acid transport GO:0015804 19 12 0,000 0,04372961 0,08271225 ! L-amino acid transport GO:0015807 20 12 0,000 0,04372961 0,08264429 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,04372961 0,08257643 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,04372961 0,08250869 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,04372961 0,08244106 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,04372961 0,08237354 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,04372961 0,08230614 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,04372961 0,08223884 ! cerebellum development GO:0021549 13 12 0,000 0,04372961 0,08217165 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,04372961 0,08210457 ! immunoglobulin production during immune response GO:0002381 20 12 0,000 0,04372961 0,0820376 ! histone acetylation GO:0016573 23 12 0,000 0,04372961 0,08197074 ! histone methylation GO:0016571 15 12 0,000 0,04372961 0,08190399 ! autonomic nervous system development GO:0048483 23 12 0,000 0,04372961 0,08183735 ! gland morphogenesis GO:0022612 23 12 0,000 0,04372961 0,08177081 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,04372961 0,08170438 ! peptidyl-lysine modification GO:0018205 18 12 0,000 0,04372961 0,08163807 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,04372961 0,08157185 ! response to gamma radiation GO:0010332 20 12 0,000 0,04372961 0,08150575 ! regulation of epidermis development GO:0045682 17 12 0,000 0,04372961 0,08143975 ! intestinal absorption GO:0050892 19 12 0,000 0,04372961 0,08137386 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,04372961 0,08130808 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,04372961 0,0812424 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,04372961 0,08117683 ! regulation of fatty acid oxidation GO:0046320 18 12 0,000 0,04372961 0,08111137 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,04372961 0,08104601 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,04372961 0,08098075 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,04372961 0,08091561 ! microspike assembly GO:0030035 23 12 0,000 0,04372961 0,08085056 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,04372961 0,08078562 ! response to cold GO:0009409 14 12 0,000 0,04372961 0,08072078 ! RNA localization GO:0006403 135 91 1,000 0,04511159 0,08320502 ! positive regulation of immune response GO:0050778 121 92 1,000 0,04600591 0,08478652 ! regulation of cytoskeleton organization GO:0051493 154 93 1,000 0,04690677 0,08637756 ! peptidyl-amino acid modification GO:0018193 147 93 1,000 0,04690677 0,08630846 ! N-terminal protein amino acid modification GO:0031365 18 13 0,000 0,04728757 0,08693957 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,04728757 0,08687013 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,04728757 0,0868008 ! cGMP metabolic process GO:0046068 16 13 0,000 0,04728757 0,08673158 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,04728757 0,08666248 ! water transport GO:0006833 17 13 0,000 0,04728757 0,08659348 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,04728757 0,08652459 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,04728757 0,08645581 ! lipid localization GO:0010876 24 13 0,000 0,04728757 0,08638714 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,04728757 0,08631858 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,04728757 0,08625012 ! organelle fusion GO:0048284 28 13 0,000 0,04728757 0,08618178 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,04728757 0,08611354 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,04728757 0,08604542 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,04728757 0,0859774 ! response to hexose stimulus GO:0009746 19 13 0,000 0,04728757 0,08590948 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! induction of apoptosis via death domain receptors GO:0008625 15 13 0,000 0,04728757 0,08584168 ! glutamate metabolic process GO:0006536 18 13 0,000 0,04728757 0,08577398 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,04728757 0,08570639 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 0,000 0,04728757 0,0856389 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! cytokine metabolic process GO:0042107 17 13 0,000 0,04728757 0,08557152 ! NAD metabolic process GO:0019674 21 13 0,000 0,04728757 0,08550425 ! exocrine system development GO:0035272 27 13 0,000 0,04728757 0,08543708 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,04728757 0,08537002 ! bone mineralization GO:0030282 15 13 0,000 0,04728757 0,08530306 ! regulation of exocytosis GO:0017157 17 13 0,000 0,04728757 0,08523621 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,04728757 0,08516947 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,04728757 0,08510282 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,04728757 0,08503628 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,04728757 0,08496985 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,04728757 0,08490352 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,04728757 0,08483729 ! genitalia development GO:0048806 15 13 0,000 0,04728757 0,08477117 ! regulation of cellular pH GO:0030641 20 13 0,000 0,04728757 0,08470515 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,04728757 0,08463923 ! tissue regeneration GO:0042246 21 13 0,000 0,04728757 0,08457341 ! positive regulation of bone mineralization GO:0030501 19 13 0,000 0,04728757 0,0845077 ! cofactor transport GO:0051181 19 13 0,000 0,04728757 0,08444209 ! NADP metabolic process GO:0006739 18 13 0,000 0,04728757 0,08437658 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,04728757 0,08431117 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,04728757 0,08424586 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,04728757 0,08418066 ! gas transport GO:0015669 18 13 0,000 0,04728757 0,08411555 ! regulation of RNA stability GO:0043487 28 13 0,000 0,04728757 0,08405055 ! heme biosynthetic process GO:0006783 20 13 0,000 0,04728757 0,08398564 ! regulation of axon extension GO:0030516 23 13 0,000 0,04728757 0,08392084 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,04728757 0,08385613 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,04728757 0,08379153 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,04728757 0,08372703 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,04728757 0,08366262 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,04728757 0,08359831 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,04728757 0,08353411 ! response to oxidative stress GO:0006979 141 94 1,000 0,04781413 0,08439946 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 1,000 0,04964808 0,08756947 ! protein maturation GO:0051604 129 96 1,000 0,04964808 0,08750237 ! response to light stimulus GO:0009416 153 96 1,000 0,04964808 0,08743537 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,05083249 0,08945274 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,05083249 0,08938435 ! superoxide anion generation GO:0042554 18 14 0,000 0,05083249 0,08931607 ! neuron maturation GO:0042551 21 14 0,000 0,05083249 0,08924789 ! regulation of S phase GO:0033261 18 14 0,000 0,05083249 0,08917981 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,05083249 0,08911184 ! myotube differentiation GO:0014902 21 14 0,000 0,05083249 0,08904397 ! phosphoinositide phosphorylation GO:0046854 21 14 0,000 0,05083249 0,08897621 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,05083249 0,08890854 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,05083249 0,08884098 ! inositol metabolic process GO:0006020 20 14 0,000 0,05083249 0,08877353 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,05083249 0,08870617 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,05083249 0,08863892 ! retina development in camera-type eye GO:0060041 18 14 0,000 0,05083249 0,08857177 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,05083249 0,08850472 ! gene silencing by RNA GO:0031047 20 14 0,000 0,05083249 0,08843777 ! response to cAMP GO:0051591 19 14 0,000 0,05083249 0,08837093 ! limbic system development GO:0021761 25 14 0,000 0,05083249 0,08830418 ! startle response GO:0001964 21 14 0,000 0,05083249 0,08823754 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,05083249 0,08817099 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,05083249 0,08810455 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,05083249 0,0880382 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,05083249 0,08797196 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 0,000 0,05083249 0,08790582 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,05083249 0,08783977 ! glycine metabolic process GO:0006544 22 14 0,000 0,05083249 0,08777383 ! pituitary gland development GO:0021983 23 14 0,000 0,05083249 0,08770798 ! cellular response to starvation GO:0009267 21 14 0,000 0,05083249 0,08764223 ! lysosomal transport GO:0007041 20 14 0,000 0,05083249 0,08757658 ! regulation of heart rate GO:0002027 23 14 0,000 0,05083249 0,08751103 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,05083249 0,08744558 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 0,000 0,05083249 0,08738022 GO:0060675|ureteric bud morphogenesis, ! embryo implantation GO:0007566 27 14 0,000 0,05083249 0,08731496 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,05083249 0,0872498 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,05083249 0,08718474 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,05083249 0,08711977 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,05083249 0,0870549 ! axon cargo transport GO:0008088 27 14 0,000 0,05083249 0,08699013 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,05083249 0,08692545 ! positive regulation of biomineral formation GO:0070169 20 14 0,000 0,05083249 0,08686087 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,05083249 0,08679639 ! T cell differentiation in the thymus GO:0033077 27 14 0,000 0,05083249 0,086732 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,05083249 0,08666771 ! mRNA splice site selection GO:0006376 26 14 0,000 0,05083249 0,08660351 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,05083249 0,08653941 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,05083249 0,0864754 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,05083249 0,08641148 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,05083249 0,08634766 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,05083249 0,08628394 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,05083249 0,08622031 ! muscle maintenance GO:0046716 19 14 0,000 0,05083249 0,08615677 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,05083249 0,08609333 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,05083249 0,08602998 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,05083249 0,08596672 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,05083249 0,08590355 ! epithelial to mesenchymal transition GO:0001837 22 14 0,000 0,05083249 0,08584048 ! cilium assembly GO:0042384 20 14 0,000 0,05083249 0,0857775 ! peptide hormone secretion GO:0030072 23 14 0,000 0,05083249 0,08571462 ! extracellular structure organization GO:0043062 156 99 1,000 0,05244625 0,08837097 ! Ras protein signal transduction GO:0007265 162 100 1,000 0,05339133 0,08989756 ! protein localization in organelle GO:0033365 161 100 1,000 0,05339133 0,0898318 ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,05436443 0,09140219 ! metencephalon development GO:0022037 19 15 0,000 0,05436443 0,09133542 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,05436443 0,09126875 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,05436443 0,09120218 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,05436443 0,09113571 ! embryonic forelimb morphogenesis GO:0035115 17 15 0,000 0,05436443 0,09106933 ! lipid phosphorylation GO:0046834 23 15 0,000 0,05436443 0,09100305 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 0,000 0,05436443 0,09093687 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,05436443 0,09087078 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,05436443 0,09080479 ! bile acid metabolic process GO:0008206 22 15 0,000 0,05436443 0,09073889 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 0,000 0,05436443 0,09067309 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,05436443 0,09060739 ! adult walking behavior GO:0007628 25 15 0,000 0,05436443 0,09054178 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,05436443 0,09047626 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,05436443 0,09041084 ! myoblast differentiation GO:0045445 27 15 0,000 0,05436443 0,09034552 ! centrosome cycle GO:0007098 16 15 0,000 0,05436443 0,09028028 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,05436443 0,09021515 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,05436443 0,0901501 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 0,000 0,05436443 0,09008515 ! cerebral cortex development GO:0021987 29 15 0,000 0,05436443 0,0900203 ! response to osmotic stress GO:0006970 22 15 0,000 0,05436443 0,08995553 ! vesicle coating GO:0006901 25 15 0,000 0,05436443 0,08989086 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,05436443 0,08982629 ! DNA integration GO:0015074 22 15 0,000 0,05436443 0,0897618 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,05436443 0,08969741 ! peptide secretion GO:0002790 27 15 0,000 0,05436443 0,08963311 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,05436443 0,08956891 ! regulation of vasodilation GO:0042312 24 15 0,000 0,05436443 0,08950479 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,05436443 0,08944077 ! neuron recognition GO:0008038 22 15 0,000 0,05436443 0,08937684 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,05436443 0,08931299 ! positive regulation of oxidoreductase activity GO:0051353 21 15 0,000 0,05436443 0,08924925 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,05436443 0,08918559 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,05436443 0,08912202 ! biomineral formation GO:0031214 18 15 0,000 0,05436443 0,08905854 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,05436443 0,08899516 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,05436443 0,08893186 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,05436443 0,08886865 ! dopamine metabolic process GO:0042417 30 15 0,000 0,05436443 0,08880553 ! organic cation transport GO:0015695 19 15 0,000 0,05436443 0,08874251 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,05436443 0,08867957 GO:0033014|tetrapyrrole biosynthetic process, ! regulation of BMP signaling pathway GO:0030510 21 15 0,000 0,05436443 0,08861672 ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,05436443 0,08855396 ! defense response to virus GO:0051607 27 15 0,000 0,05436443 0,08849129 ! peptide hormone processing GO:0016486 19 15 0,000 0,05436443 0,08842871 ! protein secretion GO:0009306 27 16 0,000 0,05788343 0,09408614 ! regulation of glucose metabolic process GO:0010906 22 16 0,000 0,05788343 0,09401969 ! hormone secretion GO:0046879 25 16 0,000 0,05788343 0,09395334 ! bone remodeling GO:0046849 24 16 0,000 0,05788343 0,09388708 ! endothelial cell migration GO:0043542 22 16 0,000 0,05788343 0,09382092 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,05788343 0,09375485 ! protein amino acid acetylation GO:0006473 28 16 0,000 0,05788343 0,09368887 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,05788343 0,09362299 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,05788343 0,09355719 ! glial cell development GO:0021782 24 16 0,000 0,05788343 0,09349149 ! patterning of blood vessels GO:0001569 24 16 0,000 0,05788343 0,09342588 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,05788343 0,09336037 GO:0042744|hydrogen peroxide catabolic process, ! protein polyubiquitination GO:0000209 26 16 0,000 0,05788343 0,09329494 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,05788343 0,09322961 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,05788343 0,09316437 GO:0030968|endoplasmic reticulum unfolded protein response, ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 0,000 0,05788343 0,09309922 ! fructose metabolic process GO:0006000 20 16 0,000 0,05788343 0,09303416 ! regulation of protein binding GO:0043393 27 16 0,000 0,05788343 0,09296919 ! regulation of dephosphorylation GO:0035303 33 16 0,000 0,05788343 0,09290432 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,05788343 0,09283953 ! protein export from nucleus GO:0006611 24 16 0,000 0,05788343 0,09277483 ! negative regulation of immune response GO:0050777 28 16 0,000 0,05788343 0,09271023 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,05788343 0,09264571 ! DNA replication initiation GO:0006270 25 16 0,000 0,05788343 0,09258128 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,05788343 0,09251695 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,05788343 0,0924527 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,05788343 0,09238854 ! diencephalon development GO:0021536 25 16 0,000 0,05788343 0,09232447 ! oogenesis GO:0048477 23 16 0,000 0,05788343 0,09226049 ! neural crest cell migration GO:0001755 24 16 0,000 0,05788343 0,0921966 ! G1 phase GO:0051318 27 16 0,000 0,05788343 0,09213279 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,05788343 0,09206908 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,05788343 0,09200545 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,05788343 0,09194191 ! steroid catabolic process GO:0006706 22 16 0,000 0,05788343 0,09187846 ! branched chain family amino acid metabolic process GO:0009081 24 16 0,000 0,05788343 0,09181509 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 0,000 0,05788343 0,09175182 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 0,000 0,05788343 0,09168863 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,05788343 0,09162552 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,05788343 0,09156251 ! sperm-egg recognition GO:0035036 16 16 0,000 0,05788343 0,09149958 GO:0007339|binding of sperm to zona pellucida, ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 0,000 0,05788343 0,09143673 ! nerve development GO:0021675 18 16 0,000 0,05788343 0,09137398 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,05788343 0,09131131 ! negative regulation of translation GO:0017148 22 16 0,000 0,05788343 0,09124872 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,06138953 0,09670953 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,06138953 0,09664334 ! negative regulation of defense response GO:0031348 19 17 0,000 0,06138953 0,09657724 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,06138953 0,09651122 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,06138953 0,0964453 ! glycerol metabolic process GO:0006071 20 17 0,000 0,06138953 0,09637947 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,06138953 0,09631372 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,06138953 0,09624807 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,06138953 0,09618251 ! signal complex assembly GO:0007172 29 17 0,000 0,06138953 0,09611703 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,06138953 0,09605165 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,06138953 0,09598635 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,06138953 0,09592114 ! forelimb morphogenesis GO:0035136 19 17 0,000 0,06138953 0,09585602 ! memory GO:0007613 25 17 0,000 0,06138953 0,09579099 ! keratinization GO:0031424 17 17 0,000 0,06138953 0,09572605 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,06138953 0,09566119 ! retinoid metabolic process GO:0001523 22 17 0,000 0,06138953 0,09559642 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,06138953 0,09553175 ! inactivation of MAPK activity GO:0000188 27 17 0,000 0,06138953 0,09546715 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,06138953 0,09540265 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,06138953 0,09533823 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,06138953 0,0952739 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 0,000 0,06138953 0,09520966 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,06138953 0,0951455 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,06138953 0,09508143 ! membrane budding GO:0006900 29 17 0,000 0,06138953 0,09501744 ! heme metabolic process GO:0042168 27 17 0,000 0,06138953 0,09495354 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,06138953 0,09488973 ! body fluid secretion GO:0007589 27 17 0,000 0,06138953 0,094826 ! stem cell differentiation GO:0048863 36 17 0,000 0,06138953 0,09476236 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,06138953 0,09469881 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,06138953 0,09463533 ! sensory perception of pain GO:0019233 23 17 0,000 0,06138953 0,09457195 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,06138953 0,09450865 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,06138953 0,09444543 ! negative regulation of intracellular transport GO:0032387 29 17 0,000 0,06138953 0,0943823 ! synaptogenesis GO:0007416 24 17 0,000 0,06138953 0,09431925 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,06138953 0,09425629 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,06138953 0,09419341 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,06138953 0,09413061 ! cell-cell junction organization GO:0045216 25 17 0,000 0,06138953 0,0940679 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,06138953 0,09400527 ! proximal/distal pattern formation GO:0009954 25 17 0,000 0,06138953 0,09394273 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,06138953 0,09388027 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,06138953 0,09381789 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,06138953 0,09375559 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,06138953 0,09369338 ! positive regulation of DNA replication GO:0045740 29 18 0,000 0,06488278 0,09895915 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,06488278 0,09889357 ! positive regulation of translation GO:0045727 28 18 0,000 0,06488278 0,09882808 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,06488278 0,09876268 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,06488278 0,09869736 ! cAMP metabolic process GO:0046058 33 18 0,000 0,06488278 0,09863212 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,06488278 0,09856698 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,06488278 0,09850192 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,06488278 0,09843694 ! axis specification GO:0009798 26 18 0,000 0,06488278 0,09837205 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 0,000 0,06488278 0,09830725 GO:0050886|endocrine process, ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,06488278 0,09824253 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,06488278 0,0981779 ! glutamine metabolic process GO:0006541 23 18 0,000 0,06488278 0,09811335 ! response to retinoic acid GO:0032526 25 18 0,000 0,06488278 0,09804889 ! central nervous system neuron development GO:0021954 30 18 0,000 0,06488278 0,09798451 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,06488278 0,09792021 ! fucose metabolic process GO:0006004 26 18 0,000 0,06488278 0,097856 ! response to fungus GO:0009620 19 18 0,000 0,06488278 0,09779188 ! peptide cross-linking GO:0018149 31 18 0,000 0,06488278 0,09772783 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,06488278 0,09766388 ! heart process GO:0003015 27 18 0,000 0,06488278 0,0976 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,06488278 0,09753621 GO:0006692|prostanoid metabolic process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 0,000 0,06488278 0,0974725 ! visual learning GO:0008542 35 18 0,000 0,06488278 0,09740888 ! somitogenesis GO:0001756 24 18 0,000 0,06488278 0,09734534 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,06488278 0,09728188 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,06488278 0,0972185 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,06488278 0,09715521 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,06488278 0,097092 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,06488278 0,09702887 ! vitamin transport GO:0051180 24 18 0,000 0,06488278 0,09696582 ! hormone transport GO:0009914 27 18 0,000 0,06488278 0,09690286 ! negative regulation of neuron differentiation GO:0045665 24 18 0,000 0,06488278 0,09683998 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,06488278 0,09677717 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,06488278 0,09671445 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,06488278 0,09665182 ! cell-cell recognition GO:0009988 20 18 0,000 0,06488278 0,09658926 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,06488278 0,09652678 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,06488278 0,09646438 ! regulation of glucose import GO:0046324 21 18 0,000 0,06488278 0,09640207 GO:0010827|regulation of glucose transport, ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,06488278 0,09633983 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,06836324 0,10144222 ! positive regulation of protein catabolic process GO:0045732 23 19 0,000 0,06836324 0,10137682 ! positive regulation of ossification GO:0045778 30 19 0,000 0,06836324 0,1013115 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,06836324 0,10124626 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,06836324 0,10118111 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,06836324 0,10111604 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 0,000 0,06836324 0,10105106 ! regulation of carbohydrate metabolic process GO:0006109 28 19 0,000 0,06836324 0,10098616 GO:0010675|regulation of cellular carbohydrate metabolic process, ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,06836324 0,10092134 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,06836324 0,1008566 ! regeneration GO:0031099 32 19 0,000 0,06836324 0,10079195 ! calcium-independent cell-cell adhesion GO:0016338 21 19 0,000 0,06836324 0,10072738 ! sensory perception of taste GO:0050909 23 19 0,000 0,06836324 0,1006629 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,06836324 0,10059849 ! smooth muscle contraction GO:0006939 36 19 0,000 0,06836324 0,10053417 ! peroxisome organization GO:0007031 29 19 0,000 0,06836324 0,10046993 ! digestive system process GO:0022600 30 19 0,000 0,06836324 0,10040578 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,06836324 0,1003417 ! response to vitamin A GO:0033189 26 19 0,000 0,06836324 0,10027771 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,06836324 0,10021379 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,06836324 0,10014996 ! response to starvation GO:0042594 30 19 0,000 0,06836324 0,10008622 ! sex determination GO:0007530 29 19 0,000 0,06836324 0,10002255 ! plasma membrane fusion GO:0045026 23 19 0,000 0,06836324 0,09995896 ! regulation of endothelial cell migration GO:0010594 40 19 0,000 0,06836324 0,09989545 ! cytolysis GO:0019835 20 19 0,000 0,06836324 0,09983203 ! renal system process GO:0003014 35 19 0,000 0,06836324 0,09976868 ! vasodilation GO:0042311 33 19 0,000 0,06836324 0,09970542 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 0,000 0,06836324 0,09964223 ! regulation of fatty acid metabolic process GO:0019217 28 19 0,000 0,06836324 0,09957913 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,06836324 0,0995161 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,06836324 0,09945316 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,06836324 0,09939029 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,06836324 0,09932751 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,06836324 0,0992648 ! sarcomere organization GO:0045214 23 19 0,000 0,06836324 0,09920217 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,06836324 0,09913962 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,06836324 0,09907715 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,06836324 0,09901476 GO:0043450|alkene biosynthetic process, ! somatic diversification of immunoglobulins GO:0016445 29 19 0,000 0,06836324 0,09895245 ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,06836324 0,09889022 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 0,000 0,06836324 0,09882806 ! protein stabilization GO:0050821 26 19 0,000 0,06836324 0,09876598 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,07183093 0,1037107 ! iron ion transport GO:0006826 37 20 0,000 0,07183093 0,10364564 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,07183093 0,10358066 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,07183093 0,10351576 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,07183093 0,10345094 ! response to vitamin GO:0033273 29 20 0,000 0,07183093 0,1033862 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,07183093 0,10332154 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,07183093 0,10325697 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,07183093 0,10319247 ! spinal cord development GO:0021510 31 20 0,000 0,07183093 0,10312806 ! response to ethanol GO:0045471 37 20 0,000 0,07183093 0,10306372 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,07183093 0,10299947 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 0,000 0,07183093 0,10293529 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,07183093 0,1028712 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,07183093 0,10280719 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,07183093 0,10274325 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,07183093 0,1026794 ! pallium development GO:0021543 38 20 0,000 0,07183093 0,10261562 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,07183093 0,10255192 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,07183093 0,1024883 ! positive regulation of inflammatory response GO:0050729 30 20 0,000 0,07183093 0,10242477 ! positive regulation of osteoblast differentiation GO:0045669 33 20 0,000 0,07183093 0,10236131 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,07183093 0,10229792 ! collagen catabolic process GO:0030574 25 20 0,000 0,07183093 0,10223462 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,07183093 0,1021714 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,07183093 0,10210825 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,07183093 0,10204518 ! alditol metabolic process GO:0019400 24 20 0,000 0,07183093 0,10198219 ! actin filament-based movement GO:0030048 34 20 0,000 0,07183093 0,10191928 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 0,000 0,07528592 0,10675562 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 0,000 0,07528592 0,10668984 GO:0016444|somatic cell DNA recombination, ! regulation of cell killing GO:0031341 34 21 0,000 0,07528592 0,10662415 ! myeloid leukocyte differentiation GO:0002573 33 21 0,000 0,07528592 0,10655853 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,07528592 0,106493 ! gluconeogenesis GO:0006094 25 21 0,000 0,07528592 0,10642755 ! positive regulation of bone remodeling GO:0046852 33 21 0,000 0,07528592 0,10636217 GO:0034105|positive regulation of tissue remodeling, ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,07528592 0,10629688 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,07528592 0,10623167 ! protein amino acid acylation GO:0043543 37 21 0,000 0,07528592 0,10616653 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,07528592 0,10610148 ! vesicle docking GO:0048278 27 21 0,000 0,07528592 0,10603651 ! phototransduction GO:0007602 25 21 0,000 0,07528592 0,10597161 ! visual behavior GO:0007632 39 21 0,000 0,07528592 0,1059068 ! regulation of DNA recombination GO:0000018 40 21 0,000 0,07528592 0,10584206 ! ovarian follicle development GO:0001541 30 21 0,000 0,07528592 0,10577741 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,07528592 0,10571283 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,07528592 0,10564833 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,07528592 0,10558391 ! cell aging GO:0007569 32 21 0,000 0,07528592 0,10551957 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,07528592 0,10545531 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,07528592 0,10539112 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,07528592 0,10532702 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,07528592 0,10526299 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,07528592 0,10519904 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,07528592 0,10513517 GO:0060415|muscle tissue morphogenesis, ! cholesterol biosynthetic process GO:0006695 29 21 0,000 0,07528592 0,10507137 ! leukotriene metabolic process GO:0006691 28 21 0,000 0,07528592 0,10500765 ! regulation of vasoconstriction GO:0019229 31 21 0,000 0,07528592 0,10494401 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,07528592 0,10488045 ! fatty acid transport GO:0015908 30 21 0,000 0,07528592 0,10481696 ! immunoglobulin production GO:0002377 33 21 0,000 0,07528592 0,10475355 GO:0002440|production of molecular mediator of immune response, ! platelet activation GO:0030168 28 21 0,000 0,07528592 0,10469022 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,07528592 0,10462696 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,07528592 0,10456378 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,07528592 0,10450067 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,07528592 0,10443765 ! regulation of bone mineralization GO:0030500 29 21 0,000 0,07528592 0,10437469 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,07528592 0,10431182 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,07528592 0,10424902 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,07528592 0,10418629 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,07528592 0,10412364 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,07528592 0,10406107 ! pyrimidine nucleoside metabolic process GO:0006213 26 21 0,000 0,07528592 0,10399857 ! acetyl-CoA catabolic process GO:0046356 31 21 0,000 0,07528592 0,10393614 GO:0006099|tricarboxylic acid cycle, ! regulation of multi-organism process GO:0043900 32 21 0,000 0,07528592 0,1038738 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,07872824 0,10855813 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 0,000 0,07872824 0,10849309 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,07872824 0,10842812 ! viral genome replication GO:0019079 29 22 0,000 0,07872824 0,10836323 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,07872824 0,10829842 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,07872824 0,10823369 ! leukocyte adhesion GO:0007159 38 22 0,000 0,07872824 0,10816903 ! molting cycle process GO:0022404 40 22 0,000 0,07872824 0,10810446 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! dicarboxylic acid metabolic process GO:0043648 33 22 0,000 0,07872824 0,10803995 ! glutamate signaling pathway GO:0007215 34 22 0,000 0,07872824 0,10797553 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,07872824 0,10791118 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 0,000 0,07872824 0,10784691 ! vasculogenesis GO:0001570 33 22 0,000 0,07872824 0,10778272 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,07872824 0,1077186 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,07872824 0,10765456 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,07872824 0,10759059 ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,07872824 0,1075267 ! lysosome organization GO:0007040 37 22 0,000 0,07872824 0,10746289 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,07872824 0,10739915 GO:0051693|actin filament capping, ! ureteric bud development GO:0001657 32 22 0,000 0,07872824 0,10733548 ! coenzyme catabolic process GO:0009109 33 22 0,000 0,07872824 0,1072719 ! regulation of behavior GO:0050795 38 22 0,000 0,07872824 0,10720838 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,07872824 0,10714495 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,07872824 0,10708159 ! membrane depolarization GO:0051899 35 22 0,000 0,07872824 0,1070183 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,07872824 0,10695509 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,07872824 0,10689195 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,07872824 0,10682889 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,07872824 0,1067659 ! blastocyst development GO:0001824 37 22 0,000 0,07872824 0,10670298 ! neural tube closure GO:0001843 33 22 0,000 0,07872824 0,10664014 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,07872824 0,10657738 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 0,000 0,08215795 0,11115487 ! neuron fate commitment GO:0048663 32 23 0,000 0,08215795 0,11108953 ! embryonic pattern specification GO:0009880 31 23 0,000 0,08215795 0,11102426 ! acetyl-CoA metabolic process GO:0006084 33 23 0,000 0,08215795 0,11095906 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,08215795 0,11089395 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,08215795 0,11082891 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,08215795 0,11076394 ! vesicle targeting GO:0006903 32 23 0,000 0,08215795 0,11069905 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,08215795 0,11063424 ! osteoblast differentiation GO:0001649 40 23 0,000 0,08215795 0,11056951 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,08215795 0,11050485 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,08215795 0,11044026 ! interaction with host GO:0051701 37 23 0,000 0,08215795 0,11037575 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,08215795 0,11031132 ! regulation of biomineral formation GO:0070167 31 23 0,000 0,08215795 0,11024696 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 0,000 0,08215795 0,11018267 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 0,000 0,08215795 0,11011846 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! glycolipid metabolic process GO:0006664 36 23 0,000 0,08215795 0,11005433 ! cell fate determination GO:0001709 45 23 0,000 0,08215795 0,10999027 ! pentose metabolic process GO:0019321 31 23 0,000 0,08215795 0,10992629 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,08215795 0,10986238 ! spermatid development GO:0007286 33 23 0,000 0,08215795 0,10979854 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,08215795 0,10973478 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,08215795 0,10967109 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,08215795 0,10960747 ! somatic diversification of immune receptors GO:0002200 35 23 0,000 0,08215795 0,10954393 ! telomere organization GO:0032200 32 23 0,000 0,08215795 0,10948047 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,08215795 0,10941707 ! regulation of amine transport GO:0051952 38 23 0,000 0,08215795 0,10935375 ! liver development GO:0001889 40 23 0,000 0,08215795 0,10929051 ! positive regulation of cell projection organization GO:0031346 39 24 0,000 0,08557508 0,11377034 ! regulation of cellular catabolic process GO:0031329 36 24 0,000 0,08557508 0,11370462 ! initiation of viral infection GO:0019059 42 24 0,000 0,08557508 0,11363897 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,08557508 0,11357339 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,08557508 0,1135079 ! superoxide metabolic process GO:0006801 32 24 0,000 0,08557508 0,11344247 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,08557508 0,11337713 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,08557508 0,11331186 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,08557508 0,11324666 ! sperm motility GO:0030317 27 24 0,000 0,08557508 0,11318154 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,08557508 0,11311649 ! vacuole organization GO:0007033 39 24 0,000 0,08557508 0,11305152 ! receptor metabolic process GO:0043112 37 24 0,000 0,08557508 0,11298662 ! neural crest cell development GO:0014032 39 24 0,000 0,08557508 0,1129218 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,08557508 0,11285705 ! primary neural tube formation GO:0014020 35 24 0,000 0,08557508 0,11279237 ! negative regulation of cell development GO:0010721 56 24 0,000 0,08557508 0,11272777 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,08557508 0,11266325 ! base-excision repair GO:0006284 31 24 0,000 0,08557508 0,11259879 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,08557508 0,11253442 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,08557508 0,11247011 ! regulation of oxidoreductase activity GO:0051341 39 24 0,000 0,08557508 0,11240588 ! glutathione metabolic process GO:0006749 29 24 0,000 0,08557508 0,11234172 ! regulation of osteoblast differentiation GO:0045667 37 24 0,000 0,08557508 0,11227763 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,08557508 0,11221362 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,08557508 0,11214968 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,08897969 0,11654515 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,08897969 0,11647882 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,08897969 0,11641256 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,08897969 0,11634638 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,08897969 0,11628028 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,08897969 0,11621425 ! regulation of cellular ketone metabolic process GO:0010565 34 25 0,000 0,08897969 0,11614829 ! peptide transport GO:0015833 43 25 0,000 0,08897969 0,11608241 ! male gonad development GO:0008584 33 25 0,000 0,08897969 0,1160166 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,08897969 0,11595087 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,08897969 0,11588521 ! phospholipid transport GO:0015914 35 25 0,000 0,08897969 0,11581963 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,08897969 0,11575412 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,08897969 0,11568869 ! detection of light stimulus GO:0009583 30 25 0,000 0,08897969 0,11562333 ! leukocyte proliferation GO:0070661 39 25 0,000 0,08897969 0,11555804 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,09237181 0,1198957 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,09237181 0,11982807 ! translational initiation GO:0006413 43 26 0,000 0,09237181 0,11976053 ! regulation of pH GO:0006885 36 26 0,000 0,09237181 0,11969306 ! circadian rhythm GO:0007623 42 26 0,000 0,09237181 0,11962566 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 0,000 0,09237181 0,11955834 ! post-embryonic development GO:0009791 42 26 0,000 0,09237181 0,1194911 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,09237181 0,11942393 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,09237181 0,11935684 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,09237181 0,11928982 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,09237181 0,11922288 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,09237181 0,11915601 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,09237181 0,11908922 ! regulation of coagulation GO:0050818 39 26 0,000 0,09237181 0,11902251 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,0957515 0,12330821 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,0957515 0,1232392 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,0957515 0,12317028 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,0957515 0,12310143 ! membrane docking GO:0022406 39 27 0,000 0,0957515 0,12303266 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,0957515 0,12296396 ! catechol metabolic process GO:0009712 43 27 0,000 0,0957515 0,12289534 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,0957515 0,1228268 ! acute-phase response GO:0006953 42 27 0,000 0,0957515 0,12275834 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 0,000 0,0957515 0,12268995 ! myofibril assembly GO:0030239 36 27 0,000 0,0957515 0,12262163 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,0957515 0,1225534 ! response to ionizing radiation GO:0010212 47 27 0,000 0,0957515 0,12248524 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,0957515 0,12241715 ! natural killer cell activation GO:0030101 35 27 0,000 0,0957515 0,12234914 ! lipid oxidation GO:0034440 38 27 0,000 0,0957515 0,12228121 GO:0019395|fatty acid oxidation, ! cofactor catabolic process GO:0051187 45 27 0,000 0,0957515 0,12221335 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,0957515 0,12214557 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,0957515 0,12207786 ! negative regulation of protein transport GO:0051224 49 27 0,000 0,0957515 0,12201023 ! gene silencing GO:0016458 41 27 0,000 0,0957515 0,12194267 ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 0,000 0,0991188 0,12616117 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,0991188 0,12609139 ! phenol metabolic process GO:0018958 44 28 0,000 0,0991188 0,12602169 ! negative regulation of protein complex assembly GO:0031333 42 28 0,000 0,0991188 0,12595206 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,0991188 0,12588252 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,0991188 0,12581304 ! positive regulation of endocytosis GO:0045807 33 28 0,000 0,0991188 0,12574365 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,0991188 0,12567433 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,0991188 0,12560509 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,0991188 0,12553592 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,0991188 0,12546683 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,0991188 0,12539782 ! response to organic cyclic substance GO:0014070 47 28 0,000 0,0991188 0,12532888 ! regulation of systemic arterial blood pressure GO:0003073 47 28 0,000 0,0991188 0,12526002 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,0991188 0,12519123 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,0991188 0,12512252 ! mesoderm formation GO:0001707 46 28 0,000 0,0991188 0,12505389 ! positive regulation of multicellular organism growth GO:0040018 38 28 0,000 0,0991188 0,12498533 ! negative regulation of MAP kinase activity GO:0043407 54 28 0,000 0,0991188 0,12491684 ! sterol biosynthetic process GO:0016126 40 28 0,000 0,0991188 0,12484843 ! BMP signaling pathway GO:0030509 40 28 0,000 0,0991188 0,1247801 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,0991188 0,12471184 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,0991188 0,12464365 ! neural tube formation GO:0001841 41 28 0,000 0,0991188 0,12457554 ! positive regulation of catabolic process GO:0009896 40 28 0,000 0,0991188 0,1245075 ! placenta development GO:0001890 37 28 0,000 0,0991188 0,12443954 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,10247375 0,12858135 ! regulation of innate immune response GO:0045088 38 29 0,000 0,10247375 0,12851124 ! ovulation cycle process GO:0022602 41 29 0,000 0,10247375 0,12844121 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,10247375 0,12837125 ! protein targeting to membrane GO:0006612 53 29 0,000 0,10247375 0,12830137 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,10247375 0,12823157 ! mismatch repair GO:0006298 34 29 0,000 0,10247375 0,12816184 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,10247375 0,12809218 ! muscle cell development GO:0055001 38 29 0,000 0,10247375 0,12802261 ! formation of primary germ layer GO:0001704 48 29 0,000 0,10247375 0,12795311 ! telencephalon development GO:0021537 52 29 0,000 0,10247375 0,12788368 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,10247375 0,12781433 ! eye morphogenesis GO:0048592 51 29 0,000 0,10247375 0,12774505 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,10247375 0,12767585 ! tissue homeostasis GO:0001894 42 29 0,000 0,10247375 0,12760672 GO:0048871|multicellular organismal homeostasis, ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 0,000 0,10581639 0,13169789 ! collagen metabolic process GO:0032963 40 30 0,000 0,10581639 0,13162667 ! organic anion transport GO:0015711 51 30 0,000 0,10581639 0,13155552 ! cholesterol transport GO:0030301 46 30 0,000 0,10581639 0,13148444 GO:0015918|sterol transport, ! embryonic skeletal system morphogenesis GO:0048704 42 30 0,000 0,10581639 0,13141345 ! spliceosome assembly GO:0000245 49 30 0,000 0,10581639 0,13134253 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,10581639 0,13127169 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,10581639 0,13120092 ! positive regulation of neurogenesis GO:0050769 45 30 0,000 0,10581639 0,13113023 ! ceramide metabolic process GO:0006672 43 30 0,000 0,10581639 0,13105962 ! ovulation cycle GO:0042698 43 30 0,000 0,10581639 0,13098908 ! hindbrain development GO:0030902 45 30 0,000 0,10581639 0,13091862 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,10581639 0,13084823 ! adult locomotory behavior GO:0008344 47 30 0,000 0,10581639 0,13077792 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,10581639 0,13070768 ! response to heat GO:0009408 41 30 0,000 0,10581639 0,13063752 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,10581639 0,13056744 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,10914678 0,13460461 ! negative regulation of secretion GO:0051048 49 31 0,000 0,10914678 0,13453248 ! glial cell differentiation GO:0010001 55 31 0,000 0,10914678 0,13446042 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,10914678 0,13438844 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 0,000 0,10914678 0,13431653 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,10914678 0,13424471 ! odontogenesis GO:0042476 50 31 0,000 0,10914678 0,13417296 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,10914678 0,13410128 ! segmentation GO:0035282 41 31 0,000 0,10914678 0,13402968 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,10914678 0,13395816 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,10914678 0,13388672 ! metanephros development GO:0001656 58 31 0,000 0,10914678 0,13381535 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,10914678 0,13374406 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,10914678 0,13367284 ! cell fate specification GO:0001708 37 31 0,000 0,10914678 0,1336017 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,10914678 0,13353064 GO:0060326|cell chemotaxis, ! RNA modification GO:0009451 40 31 0,000 0,10914678 0,13345965 ! regulation of muscle development GO:0048634 48 32 0,000 0,11246496 0,13744389 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 0,000 0,11246496 0,1373709 ! negative regulation of DNA metabolic process GO:0051053 48 32 0,000 0,11246496 0,13729798 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,11246496 0,13722515 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,11246496 0,13715239 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,11246496 0,1370797 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,11246496 0,1370071 ! regulation of protein stability GO:0031647 48 32 0,000 0,11246496 0,13693457 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,11246496 0,13686212 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,11246496 0,13678974 ! cytokine production GO:0001816 44 32 0,000 0,11246496 0,13671744 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,11246496 0,13664522 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 0,000 0,11246496 0,13657307 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,11577096 0,14051357 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,11577096 0,14043946 ! positive regulation of DNA metabolic process GO:0051054 54 33 0,000 0,11577096 0,14036542 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,11577096 0,14029147 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,11577096 0,14021759 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,11577096 0,14014379 ! actomyosin structure organization GO:0031032 43 33 0,000 0,11577096 0,14007007 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 0,000 0,11577096 0,13999643 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,11577096 0,13992286 ! carbohydrate homeostasis GO:0033500 39 33 0,000 0,11577096 0,13984938 GO:0042593|glucose homeostasis, ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,11577096 0,13977596 ! female gonad development GO:0008585 49 33 0,000 0,11577096 0,13970263 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,11577096 0,13962937 ! positive regulation of cell development GO:0010720 54 33 0,000 0,11577096 0,13955619 ! lipid homeostasis GO:0055088 55 33 0,000 0,11577096 0,13948309 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,11577096 0,13941006 ! regulation of proteolysis GO:0030162 50 33 0,000 0,11577096 0,13933711 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,11577096 0,13926423 ! androgen receptor signaling pathway GO:0030521 54 33 0,000 0,11577096 0,13919143 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 0,000 0,11577096 0,13911871 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 0,000 0,11906484 0,14300216 ! mRNA catabolic process GO:0006402 48 34 0,000 0,11906484 0,14292752 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,11906484 0,14285296 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 0,000 0,11906484 0,14277848 ! establishment or maintenance of cell polarity GO:0007163 61 34 0,000 0,11906484 0,14270408 ! feeding behavior GO:0007631 45 34 0,000 0,11906484 0,14262976 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,11906484 0,14255551 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,11906484 0,14248134 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,11906484 0,14240724 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,11906484 0,14233323 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,11906484 0,14225929 ! neuron migration GO:0001764 46 34 0,000 0,11906484 0,14218543 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,11906484 0,14211164 ! female gamete generation GO:0007292 43 34 0,000 0,11906484 0,14203793 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,11906484 0,1419643 ! polyol metabolic process GO:0019751 44 34 0,000 0,11906484 0,14189074 ! aerobic respiration GO:0009060 47 34 0,000 0,11906484 0,14181726 ! dorsal/ventral pattern formation GO:0009953 44 34 0,000 0,11906484 0,14174386 ! embryonic organ development GO:0048568 45 34 0,000 0,11906484 0,14167053 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,11906484 0,14159728 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,12234664 0,14542494 ! Notch signaling pathway GO:0007219 56 35 0,000 0,12234664 0,14534983 ! regulation of intracellular protein transport GO:0033157 59 35 0,000 0,12234664 0,14527479 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,12234664 0,14519983 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,12234664 0,14512494 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,12234664 0,14505014 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,12234664 0,14497541 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,12234664 0,14490075 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,12234664 0,14482618 ! glycogen metabolic process GO:0005977 48 35 0,000 0,12234664 0,14475168 ! pigment metabolic process GO:0042440 61 35 0,000 0,12234664 0,14467726 ! protein homooligomerization GO:0051260 52 35 0,000 0,12234664 0,14460291 ! positive regulation of transcription factor activity GO:0051091 49 36 0,000 0,12561639 0,14839122 GO:0090047|positive regulation of transcription regulator activity, ! regulation of hormone secretion GO:0046883 48 36 0,000 0,12561639 0,14831504 ! cellular amide metabolic process GO:0043603 52 36 0,000 0,12561639 0,14823895 ! negative regulation of binding GO:0051100 58 36 0,000 0,12561639 0,14816293 ! organic ether metabolic process GO:0018904 46 36 0,000 0,12561639 0,14808698 ! tissue remodeling GO:0048771 62 36 0,000 0,12561639 0,14801112 ! neural tube development GO:0021915 50 36 0,000 0,12561639 0,14793533 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,12561639 0,14785962 ! development of primary female sexual characteristics GO:0046545 52 36 0,000 0,12561639 0,14778399 GO:0046660|female sex differentiation, ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,12561639 0,14770844 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,12561639 0,14763296 ! glucan metabolic process GO:0044042 49 36 0,000 0,12561639 0,14755756 GO:0006073|cellular glucan metabolic process, ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 0,000 0,12887416 0,15130708 ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,12887416 0,15122988 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,12887416 0,15115276 ! learning GO:0007612 67 37 0,000 0,12887416 0,15107572 ! ion transmembrane transport GO:0034220 56 37 0,000 0,12887416 0,15099876 ! ribonucleoside metabolic process GO:0009119 48 37 0,000 0,12887416 0,15092187 ! regulation of protein secretion GO:0050708 51 37 0,000 0,12887416 0,15084507 ! amino acid activation GO:0043038 52 37 0,000 0,12887416 0,15076834 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,12887416 0,15069169 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,13211997 0,1544085 ! gliogenesis GO:0042063 71 38 0,000 0,13211997 0,15433008 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,13211997 0,15425174 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,13211997 0,15417348 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,13211997 0,1540953 ! phagocytosis GO:0006909 60 38 0,000 0,13211997 0,1540172 ! mesenchymal cell development GO:0014031 64 38 0,000 0,13211997 0,15393917 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! maintenance of location in cell GO:0051651 69 38 0,000 0,13211997 0,15386123 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 0,000 0,13535387 0,15754752 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 0,000 0,13535387 0,15746783 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,13535387 0,15738822 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 0,000 0,13535387 0,15730869 ! multicellular organismal metabolic process GO:0044236 50 39 0,000 0,13535387 0,15722924 ! male sex differentiation GO:0046661 53 39 0,000 0,13535387 0,15714988 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,13535387 0,15707059 ! chromatin remodeling GO:0006338 68 39 0,000 0,13535387 0,15699138 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,13535387 0,15691225 ! JNK cascade GO:0007254 54 39 0,000 0,13535387 0,1568332 ! developmental growth GO:0048589 62 39 0,000 0,13535387 0,15675423 ! cell growth GO:0016049 61 39 0,000 0,13535387 0,15667534 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,13857591 0,16032424 ! response to calcium ion GO:0051592 58 40 0,000 0,13857591 0,16024364 ! stress-activated protein kinase signaling pathway GO:0031098 55 40 0,000 0,13857591 0,16016311 ! regulation of tube size GO:0035150 60 40 0,000 0,13857591 0,16008267 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 0,000 0,13857591 0,1600023 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,13857591 0,15992202 ! peptide metabolic process GO:0006518 56 40 0,000 0,13857591 0,15984182 ! inner ear development GO:0048839 57 40 0,000 0,13857591 0,1597617 ! ATP synthesis coupled electron transport GO:0042773 48 40 0,000 0,13857591 0,15968166 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 0,000 0,13857591 0,1596017 ! double-strand break repair GO:0006302 67 40 0,000 0,13857591 0,15952182 ! B cell differentiation GO:0030183 62 40 0,000 0,13857591 0,15944202 ! JAK-STAT cascade GO:0007259 53 40 0,000 0,13857591 0,1593623 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,13857591 0,15928265 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,14178612 0,16289115 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,14178612 0,16280983 ! endosome transport GO:0016197 71 41 0,000 0,14178612 0,16272858 ! striated muscle contraction GO:0006941 62 41 0,000 0,14178612 0,16264742 ! positive regulation of DNA binding GO:0043388 57 41 0,000 0,14178612 0,16256634 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,14178612 0,16248534 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,14178612 0,16240442 ! mitochondrial transport GO:0006839 60 42 0,000 0,14498456 0,16598531 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,14498456 0,16590273 ! regulation of nucleocytoplasmic transport GO:0046822 70 42 0,000 0,14498456 0,16582023 ! regulation of JAK-STAT cascade GO:0046425 61 42 0,000 0,14498456 0,16573782 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,14498456 0,16565548 ! branching morphogenesis of a tube GO:0048754 72 42 0,000 0,14498456 0,16557323 ! embryonic skeletal system development GO:0048706 56 42 0,000 0,14498456 0,16549106 ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,14498456 0,16540897 ! excretion GO:0007588 63 42 0,000 0,14498456 0,16532696 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,14498456 0,16524504 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,14498456 0,16516319 ! positive regulation of binding GO:0051099 59 43 0,000 0,14817126 0,16870985 ! regulation of gene-specific transcription GO:0032583 69 43 0,000 0,14817126 0,16862637 ! leukocyte migration GO:0050900 60 43 0,000 0,14817126 0,16854297 ! neuromuscular process GO:0050905 79 43 0,000 0,14817126 0,16845966 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,14817126 0,16837643 ! tRNA processing GO:0008033 49 43 0,000 0,14817126 0,16829328 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,14817126 0,16821021 ! vesicle organization GO:0016050 79 43 0,000 0,14817126 0,16812723 ! epithelial tube morphogenesis GO:0060562 65 43 0,000 0,14817126 0,16804432 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,15134626 0,17156057 ! regulation of cell projection organization GO:0031344 83 44 0,000 0,15134626 0,17147606 ! glycolysis GO:0006096 53 44 0,000 0,15134626 0,17139163 ! regulation of ion transport GO:0043269 57 44 0,000 0,15134626 0,17130728 ! negative regulation of cell migration GO:0030336 92 44 0,000 0,15134626 0,17122302 ! induction of apoptosis by extracellular signals GO:0008624 74 44 0,000 0,15134626 0,17113884 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,15134626 0,17105474 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,15134626 0,17097072 ! regulation of inflammatory response GO:0050727 60 44 0,000 0,15134626 0,17088679 ! RNA catabolic process GO:0006401 64 45 0,000 0,15450961 0,17437296 ! positive regulation of defense response GO:0031349 59 45 0,000 0,15450961 0,17428744 ! regulation of translational initiation GO:0006446 64 45 0,000 0,15450961 0,17420201 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,15450961 0,17411666 ! vascular process in circulatory system GO:0003018 69 45 0,000 0,15450961 0,17403139 ! cell recognition GO:0008037 58 45 0,000 0,15450961 0,17394621 ! cell maturation GO:0048469 60 45 0,000 0,15450961 0,17386111 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,15766135 0,17732083 ! cell redox homeostasis GO:0045454 63 46 0,000 0,15766135 0,17723416 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,15766135 0,17714758 ! regulation of ossification GO:0030278 71 46 0,000 0,15766135 0,17706108 ! histone modification GO:0016570 68 46 0,000 0,15766135 0,17697467 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,15766135 0,17688834 ! respiratory electron transport chain GO:0022904 59 47 0,000 0,16080152 0,1803235 ! viral infectious cycle GO:0019058 71 47 0,000 0,16080152 0,18023562 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,16080152 0,18014783 ! covalent chromatin modification GO:0016569 75 47 0,000 0,16080152 0,18006012 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,16080152 0,1799725 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,16080152 0,17988497 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,16080152 0,17979752 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,16080152 0,17971015 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,16080152 0,17962287 ! chloride transport GO:0006821 67 48 0,000 0,16393016 0,18302882 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,16393016 0,18294002 ! response to temperature stimulus GO:0009266 62 48 0,000 0,16393016 0,1828513 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,16393016 0,18276266 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,16393016 0,18267411 ! gastrulation GO:0007369 73 48 0,000 0,16393016 0,18258565 ! regulation of DNA replication GO:0006275 75 48 0,000 0,16393016 0,18249728 ! immunoglobulin mediated immune response GO:0016064 66 48 0,000 0,16393016 0,18240898 GO:0019724|B cell mediated immunity, ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 0,000 0,16393016 0,18232078 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,16393016 0,18223266 ! regulation of endocytosis GO:0030100 63 48 0,000 0,16393016 0,18214462 ! nuclear export GO:0051168 69 48 0,000 0,16393016 0,18205667 ! positive regulation of cytokine production GO:0001819 73 48 0,000 0,16393016 0,18196881 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,16704732 0,18533953 ! sensory perception of smell GO:0007608 61 49 0,000 0,16704732 0,18525016 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,16704732 0,18516088 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 0,000 0,16704732 0,18507169 ! RNA elongation GO:0006354 62 49 0,000 0,16704732 0,18498259 ! regulation of intracellular transport GO:0032386 78 49 0,000 0,16704732 0,18489357 ! morphogenesis of a branching structure GO:0001763 86 49 0,000 0,16704732 0,18480463 ! germ cell development GO:0007281 68 49 0,000 0,16704732 0,18471579 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,16704732 0,18462702 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,16704732 0,18453835 ! cartilage development GO:0051216 70 49 0,000 0,16704732 0,18444975 ! maintenance of location GO:0051235 84 49 0,000 0,16704732 0,18436125 ! regulation of actin filament length GO:0030832 72 50 0,000 0,17015303 0,18769879 ! membrane fusion GO:0006944 80 50 0,000 0,17015303 0,18760881 ! lipid modification GO:0030258 73 50 0,000 0,17015303 0,18751892 ! regulation of multicellular organism growth GO:0040014 65 50 0,000 0,17015303 0,18742911 ! proton transport GO:0015992 75 50 0,000 0,17015303 0,18733939 ! positive regulation of secretion GO:0051047 71 51 0,000 0,17324735 0,19065497 ! hydrogen transport GO:0006818 77 51 0,000 0,17324735 0,1905638 ! activation of phospholipase C activity GO:0007202 87 51 0,000 0,17324735 0,1904727 GO:0010863|positive regulation of phospholipase C activity, ! positive regulation of cell migration GO:0030335 92 51 0,000 0,17324735 0,1903817 ! regulation of protein catabolic process GO:0042176 77 51 0,000 0,17324735 0,19029078 ! adult behavior GO:0030534 80 51 0,000 0,17324735 0,19019995 ! negative regulation of cell motion GO:0051271 104 51 0,000 0,17324735 0,19010921 ! transition metal ion transport GO:0000041 74 52 0,000 0,1763303 0,19339995 ! regulation of cellular component size GO:0032535 74 52 0,000 0,1763303 0,19330776 ! positive regulation of phospholipase activity GO:0010518 88 52 0,000 0,1763303 0,19321567 ! aging GO:0007568 79 52 0,000 0,1763303 0,19312366 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,1763303 0,19303174 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,1763303 0,19293991 ! glycerophospholipid biosynthetic process GO:0046474 75 53 0,000 0,17940193 0,19620753 ! regulation of bone remodeling GO:0046850 90 53 0,000 0,17940193 0,19611428 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,17940193 0,19602111 ! single fertilization GO:0007338 59 53 0,000 0,17940193 0,19592803 ! cell projection assembly GO:0030031 76 53 0,000 0,17940193 0,19583504 ! amino acid transport GO:0006865 84 54 0,000 0,18246228 0,19908124 ! regulation of protein complex assembly GO:0043254 81 54 0,000 0,18246228 0,19898684 ! glucose catabolic process GO:0006007 66 54 0,000 0,18246228 0,19889253 ! regulation of phospholipase activity GO:0010517 90 54 0,000 0,18246228 0,19879832 ! regulation of tissue remodeling GO:0034103 91 54 0,000 0,18246228 0,19870419 ! positive regulation of lipase activity GO:0060193 90 54 0,000 0,18246228 0,19861015 ! exocytosis GO:0006887 74 55 0,000 0,18551139 0,20183359 ! mesoderm development GO:0007498 76 55 0,000 0,18551139 0,20173816 ! nucleoside metabolic process GO:0009116 69 55 0,000 0,18551139 0,20164282 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,18551139 0,20154757 ! regulation of lipid metabolic process GO:0019216 84 56 0,000 0,18854931 0,20475138 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,18854931 0,20465475 ! positive regulation of cell motion GO:0051272 99 56 0,000 0,18854931 0,20455821 ! multicellular organism reproduction GO:0032504 83 57 0,000 0,19157607 0,20774397 GO:0048609|reproductive process in a multicellular organism, ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,19157607 0,20764607 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,19157607 0,20754826 ! camera-type eye development GO:0043010 88 57 0,000 0,19157607 0,20745055 ! secondary metabolic process GO:0019748 84 57 0,000 0,19157607 0,20735292 ! developmental maturation GO:0021700 75 57 0,000 0,19157607 0,20725539 ! gonad development GO:0008406 79 57 0,000 0,19157607 0,20715795 ! viral reproductive process GO:0022415 87 58 0,000 0,19459171 0,21031999 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,19459171 0,2102212 ! steroid hormone receptor signaling pathway GO:0030518 96 58 0,000 0,19459171 0,2101225 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,19459171 0,2100239 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 0,000 0,19759628 0,21316671 ! activation of MAPK activity GO:0000187 84 59 0,000 0,19759628 0,21306678 ! lung development GO:0030324 94 59 0,000 0,19759628 0,21296693 ! nucleoside monophosphate metabolic process GO:0009123 95 59 0,000 0,19759628 0,21286718 ! myeloid cell differentiation GO:0030099 85 59 0,000 0,19759628 0,21276753 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,2005898 0,21588982 ! phosphoinositide metabolic process GO:0030384 87 60 0,000 0,2005898 0,21578884 ! embryonic limb morphogenesis GO:0030326 86 60 0,000 0,2005898 0,21568796 GO:0035113|embryonic appendage morphogenesis, ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,2005898 0,21558717 ! glycerolipid biosynthetic process GO:0045017 85 60 0,000 0,2005898 0,21548648 ! regulation of heart contraction GO:0008016 91 60 0,000 0,2005898 0,21538588 ! regulation of vesicle-mediated transport GO:0060627 79 60 0,000 0,2005898 0,21528537 ! fertilization GO:0009566 68 60 0,000 0,2005898 0,21518496 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,20357234 0,21828269 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,20357234 0,21818097 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,20357234 0,21807935 ! fatty acid biosynthetic process GO:0006633 92 61 0,000 0,20357234 0,21797783 ! extracellular matrix organization GO:0030198 103 61 0,000 0,20357234 0,21787639 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,20357234 0,21777506 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,20357234 0,21767381 ! neurotransmitter transport GO:0006836 81 62 0,000 0,20654391 0,2207486 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,20654391 0,22064607 ! respiratory tube development GO:0030323 99 62 0,000 0,20654391 0,22054364 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,20654391 0,2204413 ! regulation of transcription factor activity GO:0051090 97 63 0,000 0,20950457 0,22349745 GO:0090046|regulation of transcription regulator activity, ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,20950457 0,22339384 ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 0,000 0,20950457 0,22329032 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 0,000 0,20950457 0,22318689 ! viral reproduction GO:0016032 92 63 0,000 0,20950457 0,22308357 ! regulation of lipase activity GO:0060191 109 63 0,000 0,20950457 0,22298033 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,21245435 0,22601526 ! appendage morphogenesis GO:0035107 93 64 0,000 0,21245435 0,22591077 GO:0035108|limb morphogenesis, ! regulation of actin cytoskeleton organization GO:0032956 97 64 0,000 0,21245435 0,22580638 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,21245435 0,22570208 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 0,000 0,21245435 0,22559787 ! hexose catabolic process GO:0019320 82 64 0,000 0,21245435 0,22549377 ! respiratory system development GO:0060541 100 64 0,000 0,21245435 0,22538976 ! adaptive immune response GO:0002250 94 64 0,000 0,21245435 0,22528584 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! reproductive structure development GO:0048608 90 65 0,000 0,21539329 0,22829703 ! appendage development GO:0048736 94 65 0,000 0,21539329 0,22819187 GO:0060173|limb development, ! B cell activation GO:0042113 104 65 0,000 0,21539329 0,22808681 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,21539329 0,22798185 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,21539329 0,22787698 ! defense response to bacterium GO:0042742 73 65 0,000 0,21539329 0,22777221 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,21539329 0,22766754 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,21539329 0,22756296 ! regulation of actin filament-based process GO:0032970 99 66 0,000 0,21832143 0,23055064 ! antigen processing and presentation GO:0019882 96 66 0,000 0,21832143 0,23044483 ! regulation of Rho protein signal transduction GO:0035023 111 66 0,000 0,21832143 0,23033912 ! regulation of immune effector process GO:0002697 101 66 0,000 0,21832143 0,23023351 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,22123881 0,23320314 ! regulation of neuron differentiation GO:0045664 107 67 0,000 0,22123881 0,23309632 ! acute inflammatory response GO:0002526 92 68 0,000 0,22414547 0,23605063 ! learning or memory GO:0007611 123 68 0,000 0,22414547 0,2359426 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,22414547 0,23583466 ! development of primary sexual characteristics GO:0045137 92 68 0,000 0,22414547 0,23572683 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,22414547 0,23561909 ! rhythmic process GO:0048511 105 68 0,000 0,22414547 0,23551146 ! inorganic anion transport GO:0015698 93 68 0,000 0,22414547 0,23540392 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,22704145 0,23833652 ! activation of protein kinase activity GO:0032147 102 69 0,000 0,22704145 0,23822779 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,22704145 0,23811916 ! response to metal ion GO:0010038 103 70 0,000 0,22992678 0,24103537 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 0,000 0,22992678 0,24092555 ! humoral immune response GO:0006959 86 70 0,000 0,22992678 0,24081584 ! eye development GO:0001654 111 70 0,000 0,22992678 0,24070623 ! amine transport GO:0015837 101 70 0,000 0,22992678 0,24059672 ! positive regulation of phosphorylation GO:0042327 102 70 0,000 0,22992678 0,24048731 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,22992678 0,240378 ! regulation of catabolic process GO:0009894 106 70 0,000 0,22992678 0,24026878 ! muscle cell differentiation GO:0042692 104 71 0,000 0,23280151 0,24316234 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,23280151 0,24305196 ! lymphocyte differentiation GO:0030098 113 71 0,000 0,23280151 0,24294168 ! monosaccharide catabolic process GO:0046365 91 71 0,000 0,23280151 0,2428315 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 0,000 0,23566567 0,24570763 GO:0045937|positive regulation of phosphate metabolic process, ! response to hypoxia GO:0001666 132 72 0,000 0,23566567 0,2455963 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,23566567 0,24548507 ! negative regulation of transport GO:0051051 116 73 0,000 0,2385193 0,24834513 ! regulation of blood pressure GO:0008217 107 73 0,000 0,2385193 0,24823275 ! tube morphogenesis GO:0035239 118 73 0,000 0,2385193 0,24812048 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,2385193 0,24800831 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,2385193 0,24789624 ! phospholipid biosynthetic process GO:0008654 102 74 0,000 0,24136244 0,25073786 ! response to oxygen levels GO:0070482 137 74 0,000 0,24136244 0,25062466 ! digestion GO:0007586 97 74 0,000 0,24136244 0,25051156 ! protein import into nucleus GO:0006606 118 74 0,000 0,24136244 0,25039856 ! blood coagulation GO:0007596 116 75 0,000 0,24419513 0,25322308 GO:0050817|coagulation, ! response to inorganic substance GO:0010035 115 75 0,000 0,24419513 0,25310897 ! response to nutrient GO:0007584 104 75 0,000 0,24419513 0,25299495 ! regulation of ligase activity GO:0051340 114 75 0,000 0,24419513 0,25288104 ! nuclear import GO:0051170 121 75 0,000 0,24419513 0,25276723 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,24419513 0,25265353 ! tRNA metabolic process GO:0006399 95 76 0,000 0,2470174 0,25545864 ! response to unfolded protein GO:0006986 99 76 0,000 0,2470174 0,25534383 ! regulation of protein transport GO:0051223 114 76 0,000 0,2470174 0,25522912 GO:0070201|regulation of establishment of protein localization, ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,2498293 0,25801858 ! cholesterol metabolic process GO:0008203 109 77 0,000 0,2498293 0,25790278 ! regulation of DNA binding GO:0051101 119 77 0,000 0,2498293 0,25778707 ! sex differentiation GO:0007548 105 77 0,000 0,2498293 0,25767147 ! protein ubiquitination GO:0016567 125 77 0,000 0,2498293 0,25755598 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,2498293 0,25744059 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,2498293 0,2573253 ! positive regulation of protein modification process GO:0031401 107 78 0,000 0,25263086 0,26009443 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,25263086 0,25997806 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,25542211 0,26273294 ! cellular respiration GO:0045333 107 79 0,000 0,25542211 0,26261549 ! oxidative phosphorylation GO:0006119 105 79 0,000 0,25542211 0,26249815 ! T cell activation GO:0042110 134 79 0,000 0,25542211 0,26238091 ! regulation of lyase activity GO:0051339 133 79 0,000 0,25542211 0,26226377 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,25542211 0,26214674 ! chromatin assembly GO:0031497 102 80 0,000 0,2582031 0,26488275 GO:0006334|nucleosome assembly, ! alcohol catabolic process GO:0046164 104 80 0,000 0,2582031 0,26476466 ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,2582031 0,26464667 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,2582031 0,26452879 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,2582031 0,26441101 ! forebrain development GO:0030900 131 80 0,000 0,2582031 0,26429334 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,26097386 0,26701062 ! hemostasis GO:0007599 125 81 0,000 0,26097386 0,2668919 ! response to protein stimulus GO:0051789 111 81 0,000 0,26097386 0,26677328 ! regulation of neurological system process GO:0031644 122 81 0,000 0,26097386 0,26665477 ! vitamin metabolic process GO:0006766 103 81 0,000 0,26097386 0,26653636 ! ossification GO:0001503 134 82 0,000 0,26373443 0,26923622 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,26648485 0,27192332 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! regulation of defense response GO:0031347 117 84 0,000 0,26922515 0,27459771 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,26922515 0,274476 ! sterol metabolic process GO:0016125 120 84 0,000 0,26922515 0,27435438 ! rRNA metabolic process GO:0016072 107 85 0,000 0,27195537 0,27701388 GO:0006364|rRNA processing, ! anterior/posterior pattern formation GO:0009952 124 85 0,000 0,27195537 0,27689126 ! regulation of protein localization GO:0032880 132 85 0,000 0,27195537 0,27676874 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,27195537 0,27664633 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,27467555 0,2792899 ! nucleosome organization GO:0034728 114 87 0,000 0,27738571 0,28192096 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,27738571 0,28179644 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,27738571 0,28167203 ! female pregnancy GO:0007565 130 87 0,000 0,27738571 0,28154772 ! Wnt receptor signaling pathway GO:0016055 130 87 0,000 0,27738571 0,28142353 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,28008591 0,28403774 ! anatomical structure homeostasis GO:0060249 136 88 0,000 0,28008591 0,28391256 ! regulation of neurogenesis GO:0050767 153 89 0,000 0,28277617 0,2865133 ! reproductive developmental process GO:0003006 127 89 0,000 0,28277617 0,28638714 ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,28277617 0,28626109 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,28277617 0,28613515 ! leukocyte differentiation GO:0002521 143 90 0,000 0,28545654 0,28872033 ! hormone metabolic process GO:0042445 121 90 0,000 0,28545654 0,28859342 ! ATP metabolic process GO:0046034 137 91 0,000 0,28812704 0,29116528 ! response to virus GO:0009615 122 91 0,000 0,28812704 0,29103741 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 0,000 0,29078771 0,29359602 ! glycerophospholipid metabolic process GO:0006650 130 92 0,000 0,29078771 0,29346719 ! cell fate commitment GO:0045165 141 92 0,000 0,29078771 0,29333848 ! DNA recombination GO:0006310 146 92 0,000 0,29078771 0,29320988 ! sulfur metabolic process GO:0006790 118 92 0,000 0,29078771 0,29308139 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,29343859 0,29562363 ! carbohydrate catabolic process GO:0016052 121 93 0,000 0,29343859 0,2954942 ! electron transport chain GO:0022900 123 94 0,000 0,29607971 0,29802334 ! regulation of binding GO:0051098 151 95 0,000 0,29871111 0,30054049 ! angiogenesis GO:0001525 149 95 0,000 0,29871111 0,30040908 ! carboxylic acid transport GO:0046942 147 95 0,000 0,29871111 0,30027778 GO:0015849|organic acid transport, ! regulation of response to external stimulus GO:0032101 139 96 0,000 0,30133283 0,30278091 ! in utero embryonic development GO:0001701 147 96 0,000 0,30133283 0,30264869 ! regulation of cellular component biogenesis GO:0044087 158 96 0,000 0,30133283 0,30251659 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,30394489 0,30500578 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! calcium ion transport GO:0006816 167 99 0,000 0,30914021 0,31008395 ! protein import GO:0017038 156 99 0,000 0,30914021 0,30994877 ! regulation of translation GO:0006417 151 100 0,000 0,31172353 0,31240267 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,31172353 0,31226661 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,31172353 0,31213066 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 0,000 0,31172353 0,31199483 ! divalent metal ion transport GO:0070838 171 100 0,000 0,31172353 0,31185912 ! regulation of body fluid levels GO:0050878 154 100 0,000 0,31172353 0,31172353