pValThreshold = 0.5 scoreFile = /home/data/iti/output/study-er-neg-stratification/runs-Desmedt//out-0.3-01-0.03-300-Desmedt//go_data/6111-Wang-ermine.txt scoreCol = 2 classFile = /home/data/annotations/gene-ontology/go_daily-termdb.rdf-xml.gz bigIsBetter = true doLog = false annotFile = /home/data/annotations/ermineJ.data/HG-U133A_B_Plus_2_bioProcess.an.txt.gz classScoreMethod = 0 filterNonSpecific = false # #! Name ID Probes NumGenes RawScore Pval CorrectedPvalue Same as GeneMembers ! filopodium assembly GO:0046847 19 11 3,000 6,94E-07 1,596E-03 ! microspike assembly GO:0030035 23 12 3,000 1,035E-06 1,191E-03 ! nuclear migration GO:0007097 10 5 2,000 3,202E-06 2,455E-03 ! positive regulation of pseudopodium assembly GO:0031274 13 5 2,000 3,202E-06 1,841E-03 GO:0031272|regulation of pseudopodium assembly, ! establishment or maintenance of cell polarity GO:0007163 61 34 4,000 3,464E-06 1,593E-03 ! N-terminal protein amino acid acetylation GO:0006474 7 6 2,000 6,371E-06 2,442E-03 ! macrophage differentiation GO:0030225 10 6 2,000 6,371E-06 2,093E-03 ! regulation of lipid kinase activity GO:0043550 12 7 2,000 1,109E-05 3,189E-03 ! establishment of nucleus localization GO:0040023 13 7 2,000 1,109E-05 2,835E-03 ! insulin-like growth factor receptor signaling pathway GO:0048009 14 8 2,000 1,766E-05 4,062E-03 ! phosphoinositide 3-kinase cascade GO:0014065 23 8 2,000 1,766E-05 3,693E-03 ! insulin receptor signaling pathway GO:0008286 40 24 3,000 2,084E-05 3,995E-03 ! nucleus localization GO:0051647 15 9 2,000 2,636E-05 4,663E-03 ! regulation of DNA metabolic process GO:0051052 135 85 5,000 2,718E-05 4,465E-03 ! cell projection assembly GO:0030031 76 53 4,000 3,217E-05 4,932E-03 ! regulation of cell projection assembly GO:0060491 20 10 2,000 3,746E-05 5,385E-03 ! peptide or protein amino-terminal blocking GO:0018409 14 10 2,000 3,746E-05 5,068E-03 ! histone acetylation GO:0016573 23 12 2,000 6,799E-05 8,687E-03 ! peptidyl-lysine modification GO:0018205 18 12 2,000 6,799E-05 8,23E-03 ! dorsal/ventral pattern formation GO:0009953 44 34 3,000 8,624E-05 9,917E-03 ! cellular response to insulin stimulus GO:0032869 52 34 3,000 8,624E-05 9,445E-03 ! N-terminal protein amino acid modification GO:0031365 18 13 2,000 8,794E-05 9,193E-03 ! positive regulation of bone mineralization GO:0030501 19 13 2,000 8,794E-05 8,794E-03 ! branching involved in ureteric bud morphogenesis GO:0001658 22 14 2,000 1,114E-04 0,01067134 GO:0060675|ureteric bud morphogenesis, ! positive regulation of biomineral formation GO:0070169 20 14 2,000 1,114E-04 0,01024449 ! release of cytochrome c from mitochondria GO:0001836 23 14 2,000 1,114E-04 9,85E-03 ! activation of protein kinase activity GO:0032147 102 69 4,000 1,153E-04 9,825E-03 ! cellular response to hormone stimulus GO:0032870 109 74 4,000 1,608E-04 0,01321145 ! induction of apoptosis by intracellular signals GO:0008629 67 40 3,000 1,646E-04 0,01305333 ! protein amino acid acetylation GO:0006473 28 16 2,000 1,696E-04 0,01300174 ! negative regulation of translation GO:0017148 22 16 2,000 1,696E-04 0,01258233 ! proximal/distal pattern formation GO:0009954 25 17 2,000 2,049E-04 0,01472644 ! response to insulin stimulus GO:0032868 63 43 3,000 2,187E-04 0,01524432 ! positive regulation of DNA replication GO:0045740 29 18 2,000 2,446E-04 0,01654835 ! apoptotic mitochondrial changes GO:0008637 29 18 2,000 2,446E-04 0,01607554 ! protein amino acid autophosphorylation GO:0046777 80 45 3,000 2,613E-04 0,01669209 ! positive regulation of ossification GO:0045778 30 19 2,000 2,89E-04 0,01796681 ! cell cycle arrest GO:0007050 150 86 4,000 3,255E-04 0,01970241 ! regulation of DNA replication GO:0006275 75 48 3,000 3,358E-04 0,01980309 ! positive regulation of osteoblast differentiation GO:0045669 33 20 2,000 3,383E-04 0,01945359 ! myeloid leukocyte differentiation GO:0002573 33 21 2,000 3,927E-04 0,02203075 ! positive regulation of bone remodeling GO:0046852 33 21 2,000 3,927E-04 0,02150621 GO:0034105|positive regulation of tissue remodeling, ! protein amino acid acylation GO:0043543 37 21 2,000 3,927E-04 0,02100606 ! regulation of bone mineralization GO:0030500 29 21 2,000 3,927E-04 0,02052865 ! positive regulation of growth GO:0045927 67 50 3,000 3,932E-04 0,02009809 ! positive regulation of cell migration GO:0030335 92 51 3,000 4,244E-04 0,02122118 ! ureteric bud development GO:0001657 32 22 2,000 4,524E-04 0,02214071 ! aging GO:0007568 79 52 3,000 4,574E-04 0,02191475 ! peptidyl-amino acid modification GO:0018193 147 93 4,000 4,675E-04 0,02194172 ! 2-oxoglutarate metabolic process GO:0006103 7 5 1,000 4,687E-04 0,02155974 ! protein maturation by protein folding GO:0022417 12 5 1,000 4,687E-04 0,021137 ! positive regulation of glycolysis GO:0045821 11 5 1,000 4,687E-04 0,02073052 ! negative regulation of survival gene product expression GO:0008634 6 5 1,000 4,687E-04 0,02033938 ! valine metabolic process GO:0006573 8 5 1,000 4,687E-04 0,01996272 ! regulation of retinoic acid receptor signaling pathway GO:0048385 11 5 1,000 4,687E-04 0,01959977 ! regulation of blood volume by renin-angiotensin GO:0002016 10 5 1,000 4,687E-04 0,01924977 ! cranial nerve morphogenesis GO:0021602 6 5 1,000 4,687E-04 0,01891205 ! neural tube patterning GO:0021532 6 5 1,000 4,687E-04 0,01858598 ! regulation of respiratory burst GO:0060263 8 5 1,000 4,687E-04 0,01827097 ! determination of adult lifespan GO:0008340 8 5 1,000 4,687E-04 0,01796645 ! skeletal system morphogenesis GO:0048705 78 53 3,000 4,921E-04 0,01855309 ! kidney development GO:0001822 90 53 3,000 4,921E-04 0,01825385 ! DNA damage response, signal transduction resulting in induction of apoptosis GO:0008630 42 23 2,000 5,177E-04 0,01889969 ! peptidyl-tyrosine phosphorylation GO:0018108 35 23 2,000 5,177E-04 0,01860439 ! regulation of biomineral formation GO:0070167 31 23 2,000 5,177E-04 0,01831816 ! positive regulation of cell projection organization GO:0031346 39 24 2,000 5,887E-04 0,02051408 ! regulation of osteoblast differentiation GO:0045667 37 24 2,000 5,887E-04 0,0202079 ! positive regulation of cell motion GO:0051272 99 56 3,000 6,074E-04 0,02054503 ! regulation of lipid metabolic process GO:0019216 84 56 3,000 6,074E-04 0,02024728 ! negative regulation of cellular protein metabolic process GO:0032269 163 99 4,000 6,225E-04 0,02045296 ! negative regulation of protein kinase activity GO:0006469 99 57 3,000 6,498E-04 0,02104974 ! response to peptide hormone stimulus GO:0043434 84 57 3,000 6,498E-04 0,02075738 ! Ras protein signal transduction GO:0007265 162 100 4,000 6,517E-04 0,02053176 ! peptidyl-tyrosine modification GO:0018212 37 25 2,000 6,656E-04 0,02068668 ! negative regulation of kinase activity GO:0033673 100 58 3,000 6,942E-04 0,02128967 ! regulation of helicase activity GO:0051095 11 6 1,000 6,998E-04 0,02117965 ! regulation of protein export from nucleus GO:0046825 6 6 1,000 6,998E-04 0,02090459 ! glucocorticoid receptor signaling pathway GO:0042921 9 6 1,000 6,998E-04 0,02063658 GO:0031958|corticosteroid receptor signaling pathway, ! cGMP-mediated signaling GO:0019934 10 6 1,000 6,998E-04 0,02037536 ! thymic T cell selection GO:0045061 12 6 1,000 6,998E-04 0,02012067 ! positive regulation of muscle hypertrophy GO:0014742 9 6 1,000 6,998E-04 0,01987227 GO:0014744|positive regulation of muscle adaptation, GO:0010615|positive regulation of cardiac muscle adaptation, GO:0010613|positive regulation of cardiac muscle hypertrophy, ! male sex determination GO:0030238 9 6 1,000 6,998E-04 0,01962992 ! negative regulation of DNA recombination GO:0045910 9 6 1,000 6,998E-04 0,01939342 ! renal system process involved in regulation of systemic arterial blood pressure GO:0003071 9 6 1,000 6,998E-04 0,01916254 ! regulation of meiosis GO:0040020 10 6 1,000 6,998E-04 0,0189371 GO:0051445|regulation of meiotic cell cycle, ! midbrain development GO:0030901 6 6 1,000 6,998E-04 0,0187169 ! epidermal growth factor receptor signaling pathway GO:0007173 41 26 2,000 7,486E-04 0,01979059 ! activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 34 26 2,000 7,486E-04 0,0195657 ! urogenital system development GO:0001655 101 61 3,000 8,404E-04 0,02171816 ! fatty acid biosynthetic process GO:0006633 92 61 3,000 8,404E-04 0,02147685 ! negative regulation of transferase activity GO:0051348 105 61 3,000 8,404E-04 0,02124084 ! negative regulation of protein complex assembly GO:0031333 42 28 2,000 9,338E-04 0,0233444 ! sterol biosynthetic process GO:0016126 40 28 2,000 9,338E-04 0,02309339 ! BMP signaling pathway GO:0030509 40 28 2,000 9,338E-04 0,02284771 ! positive regulation of catabolic process GO:0009896 40 28 2,000 9,338E-04 0,02260721 ! somatic diversification of immune receptors via somatic mutation GO:0002566 9 7 1,000 9,754E-04 0,0233678 GO:0016446|somatic hypermutation of immunoglobulin genes, ! regulation of smooth muscle cell migration GO:0014910 19 7 1,000 9,754E-04 0,0231269 ! oxaloacetate metabolic process GO:0006107 9 7 1,000 9,754E-04 0,02289091 ! detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9 7 1,000 9,754E-04 0,02265969 ! microtubule bundle formation GO:0001578 8 7 1,000 9,754E-04 0,02243309 ! protein heterooligomerization GO:0051291 10 7 1,000 9,754E-04 0,02221098 ! multicellular organismal aging GO:0010259 11 7 1,000 9,754E-04 0,02199323 ! muscle adaptation GO:0043500 12 7 1,000 9,754E-04 0,0217797 ! appendage morphogenesis GO:0035107 93 64 3,000 1,007E-03 0,02227103 GO:0035108|limb morphogenesis, ! appendage development GO:0048736 94 65 3,000 1,067E-03 0,02338093 GO:0060173|limb development, ! hindbrain development GO:0030902 45 30 2,000 1,146E-03 0,02485831 ! metanephros development GO:0001656 58 31 2,000 1,262E-03 0,02712756 ! negative regulation of smooth muscle cell proliferation GO:0048662 14 8 1,000 1,295E-03 0,02756981 ! succinate metabolic process GO:0006105 14 8 1,000 1,295E-03 0,02731688 ! detection of mechanical stimulus involved in sensory perception GO:0050974 11 8 1,000 1,295E-03 0,02706854 ! keratinocyte proliferation GO:0043616 12 8 1,000 1,295E-03 0,02682468 ! middle ear morphogenesis GO:0042474 9 8 1,000 1,295E-03 0,02658517 ! positive regulation of endothelial cell migration GO:0010595 18 8 1,000 1,295E-03 0,02634991 ! regulation of muscle hypertrophy GO:0014743 11 8 1,000 1,295E-03 0,02611877 GO:0010611|regulation of cardiac muscle hypertrophy, GO:0010612|regulation of cardiac muscle adaptation, ! regulation of gliogenesis GO:0014013 20 8 1,000 1,295E-03 0,02589165 GO:0045685|regulation of glial cell differentiation, ! regulation of T cell differentiation in the thymus GO:0033081 12 8 1,000 1,295E-03 0,02566844 ! retinal ganglion cell axon guidance GO:0031290 10 8 1,000 1,295E-03 0,02544906 ! regulation of telomere maintenance GO:0032204 10 8 1,000 1,295E-03 0,02523339 ! lamellipodium assembly GO:0030032 9 8 1,000 1,295E-03 0,02502134 ! regulation of embryonic development GO:0045995 16 8 1,000 1,295E-03 0,02481283 ! positive regulation of DNA metabolic process GO:0051054 54 33 2,000 1,516E-03 0,02882588 ! positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 14 9 1,000 1,657E-03 0,03123726 ! regulation of developmental growth GO:0048638 13 9 1,000 1,657E-03 0,0309833 ! positive regulation of glucose metabolic process GO:0010907 15 9 1,000 1,657E-03 0,03073343 ! regulation of glycolysis GO:0006110 15 9 1,000 1,657E-03 0,03048756 ! T cell selection GO:0045058 18 9 1,000 1,657E-03 0,0302456 ! phosphagen metabolic process GO:0006599 12 9 1,000 1,657E-03 0,03000745 GO:0006600|creatine metabolic process, ! motor axon guidance GO:0008045 14 9 1,000 1,657E-03 0,02977301 ! positive regulation of phagocytosis GO:0050766 11 9 1,000 1,657E-03 0,02954221 ! musculoskeletal movement GO:0050881 11 9 1,000 1,657E-03 0,02931497 GO:0050879|multicellular organismal movement, ! negative regulation of BMP signaling pathway GO:0030514 13 9 1,000 1,657E-03 0,02909119 ! pyrimidine base metabolic process GO:0006206 14 9 1,000 1,657E-03 0,0288708 ! regulation of muscle adaptation GO:0043502 12 9 1,000 1,657E-03 0,02865373 ! sequestering of metal ion GO:0051238 11 9 1,000 1,657E-03 0,02843989 ! positive regulation of transcription factor activity GO:0051091 49 36 2,000 1,955E-03 0,03330475 GO:0090047|positive regulation of transcription regulator activity, ! cortical actin cytoskeleton organization GO:0030866 19 10 1,000 2,062E-03 0,03486869 ! hippocampus development GO:0021766 19 10 1,000 2,062E-03 0,03461417 ! blood vessel remodeling GO:0001974 21 10 1,000 2,062E-03 0,03436335 ! nucleobase biosynthetic process GO:0046112 21 10 1,000 2,062E-03 0,03411613 ! cranial nerve development GO:0021545 12 10 1,000 2,062E-03 0,03387244 ! DNA methylation GO:0006306 15 10 1,000 2,062E-03 0,03363221 GO:0006305|DNA alkylation, ! nitric oxide mediated signal transduction GO:0007263 17 10 1,000 2,062E-03 0,03339537 ! regulation of cellular carbohydrate catabolic process GO:0043471 16 10 1,000 2,062E-03 0,03316183 GO:0043470|regulation of carbohydrate catabolic process, ! cardiac cell differentiation GO:0035051 16 10 1,000 2,062E-03 0,03293154 ! pigmentation GO:0043473 74 38 2,000 2,287E-03 0,03626986 ! JNK cascade GO:0007254 54 39 2,000 2,465E-03 0,03882772 ! developmental growth GO:0048589 62 39 2,000 2,465E-03 0,03856359 ! synapse organization GO:0050808 55 39 2,000 2,465E-03 0,03830302 ! cortical cytoskeleton organization GO:0030865 20 11 1,000 2,509E-03 0,0387232 ! virus-host interaction GO:0019048 17 11 1,000 2,509E-03 0,03846505 ! detection of mechanical stimulus GO:0050982 15 11 1,000 2,509E-03 0,03821031 ! regulation of mRNA processing GO:0050684 18 11 1,000 2,509E-03 0,03795893 ! plasma membrane organization GO:0007009 18 11 1,000 2,509E-03 0,03771083 ! regulation of phagocytosis GO:0050764 14 11 1,000 2,509E-03 0,03746596 ! regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 19 11 1,000 2,509E-03 0,03722424 ! somatic diversification of immunoglobulins during immune response GO:0002208 19 11 1,000 2,509E-03 0,03698563 GO:0002204|somatic recombination of immunoglobulin genes during immune response, GO:0045190|isotype switching, ! negative regulation of mast cell proliferation GO:0070667 17 11 1,000 2,509E-03 0,03675005 GO:0042130|negative regulation of T cell proliferation, ! stress-activated protein kinase signaling pathway GO:0031098 55 40 2,000 2,651E-03 0,03859361 ! positive regulation of DNA binding GO:0043388 57 41 2,000 2,846E-03 0,04117142 ! positive regulation of MAP kinase activity GO:0043406 121 85 3,000 2,871E-03 0,04127378 ! anterior/posterior pattern formation GO:0009952 124 85 3,000 2,871E-03 0,04101742 ! positive regulation of cellular catabolic process GO:0031331 22 12 1,000 2,997E-03 0,0425459 ! cartilage condensation GO:0001502 18 12 1,000 2,997E-03 0,04228488 ! positive regulation of cell growth GO:0030307 16 12 1,000 2,997E-03 0,04202705 ! positive regulation of carbohydrate metabolic process GO:0045913 20 12 1,000 2,997E-03 0,04177234 GO:0010676|positive regulation of cellular carbohydrate metabolic process, ! immunoglobulin production during immune response GO:0002381 20 12 1,000 2,997E-03 0,0415207 ! autonomic nervous system development GO:0048483 23 12 1,000 2,997E-03 0,04127207 ! regulation of fatty acid oxidation GO:0046320 18 12 1,000 2,997E-03 0,0410264 ! branching morphogenesis of a tube GO:0048754 72 42 2,000 3,05E-03 0,04150608 ! skeletal muscle tissue development GO:0007519 123 87 3,000 3,123E-03 0,0422551 GO:0060538|skeletal muscle organ development, ! positive regulation of binding GO:0051099 59 43 2,000 3,262E-03 0,04387654 ! regulation of gene-specific transcription GO:0032583 69 43 2,000 3,262E-03 0,04362144 ! epithelial tube morphogenesis GO:0060562 65 43 2,000 3,262E-03 0,0433693 ! regulation of cell projection organization GO:0031344 83 44 2,000 3,483E-03 0,04604371 ! induction of apoptosis via death domain receptors GO:0008625 15 13 1,000 3,526E-03 0,04633619 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process GO:0034654 24 13 1,000 3,526E-03 0,04607291 GO:0034404|nucleobase, nucleoside and nucleotide biosynthetic process, ! leukocyte differentiation GO:0002521 143 90 3,000 3,529E-03 0,04585526 ! regulation of ossification GO:0030278 71 46 2,000 3,953E-03 0,05107386 ! histone modification GO:0016570 68 46 2,000 3,953E-03 0,05078853 ! phosphoinositide phosphorylation GO:0046854 21 14 1,000 4,095E-03 0,05232011 ! retina development in camera-type eye GO:0060041 18 14 1,000 4,095E-03 0,05203104 ! limbic system development GO:0021761 25 14 1,000 4,095E-03 0,05174516 ! pyrimidine ribonucleotide biosynthetic process GO:0009220 17 14 1,000 4,095E-03 0,0514624 ! negative regulation of microtubule depolymerization GO:0007026 31 14 1,000 4,095E-03 0,05118271 GO:0031114|regulation of microtubule depolymerization, ! negative regulation of caspase activity GO:0043154 20 14 1,000 4,095E-03 0,05090605 ! T cell differentiation in the thymus GO:0033077 27 14 1,000 4,095E-03 0,05063236 ! epithelial to mesenchymal transition GO:0001837 22 14 1,000 4,095E-03 0,0503616 ! covalent chromatin modification GO:0016569 75 47 2,000 4,201E-03 0,05139611 ! heart morphogenesis GO:0003007 65 48 2,000 4,459E-03 0,05426003 ! positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 61 48 2,000 4,459E-03 0,05397445 ! positive regulation of cell size GO:0045793 20 15 1,000 4,703E-03 0,05663602 ! skin development GO:0043588 25 15 1,000 4,703E-03 0,05634104 ! embryonic forelimb morphogenesis GO:0035115 17 15 1,000 4,703E-03 0,05604912 ! lipid phosphorylation GO:0046834 23 15 1,000 4,703E-03 0,05576021 ! negative regulation of nucleocytoplasmic transport GO:0046823 27 15 1,000 4,703E-03 0,05547426 ! regulation of epidermal growth factor receptor signaling pathway GO:0042058 21 15 1,000 4,703E-03 0,05519122 ! regulation of survival gene product expression GO:0045884 20 15 1,000 4,703E-03 0,05491107 ! pyrimidine ribonucleotide metabolic process GO:0009218 19 15 1,000 4,703E-03 0,05463374 ! cerebral cortex development GO:0021987 29 15 1,000 4,703E-03 0,0543592 ! DNA fragmentation involved in apoptosis GO:0006309 19 15 1,000 4,703E-03 0,0540874 ! positive regulation of oxidoreductase activity GO:0051353 21 15 1,000 4,703E-03 0,05381831 ! regulation of BMP signaling pathway GO:0030510 21 15 1,000 4,703E-03 0,05355188 ! negative regulation of leukocyte proliferation GO:0070664 25 15 1,000 4,703E-03 0,05328808 GO:0050672|negative regulation of lymphocyte proliferation, GO:0032945|negative regulation of mononuclear cell proliferation, ! negative regulation of microtubule polymerization or depolymerization GO:0031111 33 15 1,000 4,703E-03 0,05302686 ! morphogenesis of a branching structure GO:0001763 86 49 2,000 4,726E-03 0,05302149 ! cartilage development GO:0051216 70 49 2,000 4,726E-03 0,0527641 ! regulation of translation GO:0006417 151 100 3,000 5,137E-03 0,05707874 ! regulation of glucose metabolic process GO:0010906 22 16 1,000 5,351E-03 0,05916881 ! pyrimidine ribonucleoside metabolic process GO:0046131 20 16 1,000 5,351E-03 0,0588857 ! regulation of dephosphorylation GO:0035303 33 16 1,000 5,351E-03 0,0586053 ! protein export from nucleus GO:0006611 24 16 1,000 5,351E-03 0,05832755 ! oogenesis GO:0048477 23 16 1,000 5,351E-03 0,05805242 ! branched chain family amino acid metabolic process GO:0009081 24 16 1,000 5,351E-03 0,05777987 ! negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 21 16 1,000 5,351E-03 0,05750987 ! regulation of generation of precursor metabolites and energy GO:0043467 26 16 1,000 5,351E-03 0,05724238 ! somatic recombination of immunoglobulin gene segments GO:0016447 26 16 1,000 5,351E-03 0,05697737 ! nerve development GO:0021675 18 16 1,000 5,351E-03 0,0567148 ! establishment of organelle localization GO:0051656 85 52 2,000 5,584E-03 0,05891676 ! regulation of bone remodeling GO:0046850 90 53 2,000 5,89E-03 0,06185653 ! forelimb morphogenesis GO:0035136 19 17 1,000 6,037E-03 0,06311467 ! negative regulation of peptidase activity GO:0010466 23 17 1,000 6,037E-03 0,06282909 ! inactivation of MAPK activity GO:0000188 27 17 1,000 6,037E-03 0,06254607 ! positive regulation of nitric oxide biosynthetic process GO:0045429 30 17 1,000 6,037E-03 0,0622656 ! neuromuscular junction development GO:0007528 23 17 1,000 6,037E-03 0,06198762 ! nucleobase metabolic process GO:0009112 31 17 1,000 6,037E-03 0,06171212 ! negative regulation of intracellular transport GO:0032387 29 17 1,000 6,037E-03 0,06143906 ! synaptogenesis GO:0007416 24 17 1,000 6,037E-03 0,0611684 ! regulation of protein complex assembly GO:0043254 81 54 2,000 6,205E-03 0,06259615 ! regulation of tissue remodeling GO:0034103 91 54 2,000 6,205E-03 0,0623228 ! regulation of systemic arterial blood pressure by hormone GO:0001990 26 18 1,000 6,761E-03 0,06761109 GO:0050886|endocrine process, ! positive regulation of phosphoinositide 3-kinase cascade GO:0014068 24 18 1,000 6,761E-03 0,0673184 ! somitogenesis GO:0001756 24 18 1,000 6,761E-03 0,06702824 ! negative regulation of neuron differentiation GO:0045665 24 18 1,000 6,761E-03 0,06674056 ! negative regulation of T cell activation GO:0050868 25 18 1,000 6,761E-03 0,06645535 ! DNA damage response, signal transduction GO:0042770 96 56 2,000 6,866E-03 0,06719648 ! positive regulation of protein catabolic process GO:0045732 23 19 1,000 7,523E-03 0,07331279 ! positive regulation of fibroblast proliferation GO:0048146 27 19 1,000 7,523E-03 0,07300346 ! regulation of insulin-like growth factor receptor signaling pathway GO:0043567 27 19 1,000 7,523E-03 0,07269672 ! regulation of carbohydrate metabolic process GO:0006109 28 19 1,000 7,523E-03 0,07239255 GO:0010675|regulation of cellular carbohydrate metabolic process, ! calcium-independent cell-cell adhesion GO:0016338 21 19 1,000 7,523E-03 0,07209091 ! response to alkaloid GO:0043279 32 19 1,000 7,523E-03 0,07179178 ! positive regulation of epithelial cell proliferation GO:0050679 37 19 1,000 7,523E-03 0,07149512 ! cellular response to reactive oxygen species GO:0034614 27 19 1,000 7,523E-03 0,0712009 ! cell structure disassembly during apoptosis GO:0006921 24 19 1,000 7,523E-03 0,07090909 ! apoptotic nuclear changes GO:0030262 24 19 1,000 7,523E-03 0,07061967 ! sex determination GO:0007530 29 19 1,000 7,523E-03 0,0703326 ! regulation of endothelial cell migration GO:0010594 40 19 1,000 7,523E-03 0,07004785 ! renal system process GO:0003014 35 19 1,000 7,523E-03 0,0697654 ! regulation of phosphoinositide 3-kinase cascade GO:0014066 25 19 1,000 7,523E-03 0,06948522 ! regulation of fatty acid metabolic process GO:0019217 28 19 1,000 7,523E-03 0,06920728 ! somatic diversification of immunoglobulins GO:0016445 29 19 1,000 7,523E-03 0,06893155 ! pyrimidine nucleotide biosynthetic process GO:0006221 24 19 1,000 7,523E-03 0,06865801 ! regulation of microtubule polymerization or depolymerization GO:0031110 44 19 1,000 7,523E-03 0,06838664 ! protein stabilization GO:0050821 26 19 1,000 7,523E-03 0,0681174 ! steroid hormone receptor signaling pathway GO:0030518 96 58 2,000 7,567E-03 0,06824704 ! activation of MAPK activity GO:0000187 84 59 2,000 7,932E-03 0,07126573 ! myeloid cell differentiation GO:0030099 85 59 2,000 7,932E-03 0,07098843 ! embryonic limb morphogenesis GO:0030326 86 60 2,000 8,308E-03 0,07406461 GO:0035113|embryonic appendage morphogenesis, ! regulation of homeostatic process GO:0032844 105 60 2,000 8,308E-03 0,07377865 ! regulation of nitric oxide biosynthetic process GO:0045428 35 20 1,000 8,321E-03 0,07360686 ! pallium development GO:0021543 38 20 1,000 8,321E-03 0,07332484 ! DNA modification GO:0006304 28 20 1,000 8,321E-03 0,07304497 ! positive regulation of inflammatory response GO:0050729 30 20 1,000 8,321E-03 0,07276724 ! organelle localization GO:0051640 96 62 2,000 9,091E-03 0,07920214 ! positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 26 21 1,000 9,155E-03 0,07946116 ! somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 33 21 1,000 9,155E-03 0,07916243 GO:0016444|somatic cell DNA recombination, ! DNA catabolic process, endonucleolytic GO:0000737 26 21 1,000 9,155E-03 0,07886594 ! dendrite development GO:0016358 35 21 1,000 9,155E-03 0,07857167 ! regulation of DNA recombination GO:0000018 40 21 1,000 9,155E-03 0,07827958 ! ovarian follicle development GO:0001541 30 21 1,000 9,155E-03 0,07798965 ! activation of pro-apoptotic gene products GO:0008633 36 21 1,000 9,155E-03 0,07770187 ! cell aging GO:0007569 32 21 1,000 9,155E-03 0,0774162 ! cholesterol biosynthetic process GO:0006695 29 21 1,000 9,155E-03 0,07713262 ! regulation of vasoconstriction GO:0019229 31 21 1,000 9,155E-03 0,07685112 ! immunoglobulin production GO:0002377 33 21 1,000 9,155E-03 0,07657166 GO:0002440|production of molecular mediator of immune response, ! pyrimidine nucleoside metabolic process GO:0006213 26 21 1,000 9,155E-03 0,07629423 ! acetyl-CoA catabolic process GO:0046356 31 21 1,000 9,155E-03 0,0760188 GO:0006099|tricarboxylic acid cycle, ! regulation of transcription factor activity GO:0051090 97 63 2,000 9,498E-03 0,0785816 GO:0090046|regulation of transcription regulator activity, ! regulation of peptidyl-tyrosine phosphorylation GO:0050730 92 63 2,000 9,498E-03 0,07829995 ! intracellular receptor-mediated signaling pathway GO:0030522 104 63 2,000 9,498E-03 0,0780203 ! positive regulation of protein amino acid phosphorylation GO:0001934 87 64 2,000 9,916E-03 0,08116068 ! regulation of tyrosine phosphorylation of Stat5 protein GO:0042522 31 22 1,000 0,01002559 0,08176903 ! regulation of fibroblast proliferation GO:0048145 35 22 1,000 0,01002559 0,08148009 ! dicarboxylic acid metabolic process GO:0043648 33 22 1,000 0,01002559 0,08119319 ! odontogenesis of dentine-containing tooth GO:0042475 37 22 1,000 0,01002559 0,0809083 ! coenzyme catabolic process GO:0009109 33 22 1,000 0,01002559 0,0806254 ! protein tetramerization GO:0051262 39 22 1,000 0,01002559 0,08034448 ! regulation of caspase activity GO:0043281 97 65 2,000 0,01034386 0,08260724 ! axon guidance GO:0007411 99 66 2,000 0,01078261 0,08581314 ! regulation of Rho protein signal transduction GO:0035023 111 66 2,000 0,01078261 0,08551723 ! positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 28 23 1,000 0,01093111 0,08639708 ! positive regulation of cell adhesion GO:0045785 37 23 1,000 0,01093111 0,0861012 ! myelination GO:0042552 35 23 1,000 0,01093111 0,08580734 ! acetyl-CoA metabolic process GO:0006084 33 23 1,000 0,01093111 0,08551548 ! cellular iron ion homeostasis GO:0006879 37 23 1,000 0,01093111 0,08522559 ! interaction with host GO:0051701 37 23 1,000 0,01093111 0,08493767 ! cellular response to oxidative stress GO:0034599 33 23 1,000 0,01093111 0,08465168 ! regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 36 23 1,000 0,01093111 0,08436762 ! ribonucleoside monophosphate metabolic process GO:0009161 35 23 1,000 0,01093111 0,08408545 GO:0009156|ribonucleoside monophosphate biosynthetic process, ! somatic diversification of immune receptors GO:0002200 35 23 1,000 0,01093111 0,08380517 ! regulation of endopeptidase activity GO:0052548 99 67 2,000 0,011232 0,08582589 ! regulation of cellular catabolic process GO:0031329 36 24 1,000 0,01187133 0,0904108 ! regulation of oxidoreductase activity GO:0051341 39 24 1,000 0,01187133 0,09011241 ! transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 104 70 2,000 0,01264446 0,09566531 ! eye development GO:0001654 111 70 2,000 0,01264446 0,09535165 ! positive regulation of phosphorylation GO:0042327 102 70 2,000 0,01264446 0,09504005 ! regulation of catabolic process GO:0009894 106 70 2,000 0,01264446 0,09473047 ! negative regulation of phosphorus metabolic process GO:0010563 45 25 1,000 0,01284574 0,09592602 GO:0045936|negative regulation of phosphate metabolic process, ! regulation of cellular ketone metabolic process GO:0010565 34 25 1,000 0,01284574 0,09561558 ! iron ion homeostasis GO:0055072 39 25 1,000 0,01284574 0,09530714 ! regulation of chromosome organization GO:0033044 35 25 1,000 0,01284574 0,09500068 ! negative regulation of lymphocyte activation GO:0051250 37 25 1,000 0,01284574 0,09469619 ! phosphoinositide-mediated signaling GO:0048015 109 71 2,000 0,01313684 0,09653268 ! steroid biosynthetic process GO:0006694 94 71 2,000 0,01313684 0,09622525 ! regulation of peptidase activity GO:0052547 106 72 2,000 0,01364006 0,09959407 ! positive regulation of phosphorus metabolic process GO:0010562 107 72 2,000 0,01364006 0,0992789 GO:0045937|positive regulation of phosphate metabolic process, ! negative regulation of protein modification process GO:0031400 50 26 1,000 0,01385384 0,10051682 ! regulation of microtubule cytoskeleton organization GO:0070507 53 26 1,000 0,01385384 0,10020073 ! tube morphogenesis GO:0035239 118 73 2,000 0,01415415 0,10205183 ! mitochondrion organization GO:0007005 104 73 2,000 0,01415415 0,10173292 ! antigen processing and presentation of peptide antigen via MHC class I GO:0002474 49 27 1,000 0,01489511 0,1067251 ! cofactor catabolic process GO:0051187 45 27 1,000 0,01489511 0,10639366 ! negative regulation of leukocyte activation GO:0002695 39 27 1,000 0,01489511 0,10606426 ! negative regulation of protein transport GO:0051224 49 27 1,000 0,01489511 0,10573691 ! regulation of systemic arterial blood pressure GO:0003073 47 28 1,000 0,01596906 0,11301181 ! positive regulation of multicellular organism growth GO:0040018 38 28 1,000 0,01596906 0,11266515 ! negative regulation of MAP kinase activity GO:0043407 54 28 1,000 0,01596906 0,11232061 ! ensheathment of neurons GO:0007272 43 28 1,000 0,01596906 0,11197817 GO:0008366|axon ensheathment, ! regulation of tyrosine phosphorylation of Stat3 protein GO:0042516 39 28 1,000 0,01596906 0,11163781 ! positive regulation of endocytosis GO:0045807 33 28 1,000 0,01596906 0,11129951 ! regulation of DNA binding GO:0051101 119 77 2,000 0,01631974 0,11340001 ! positive regulation of protein modification process GO:0031401 107 78 2,000 0,01688857 0,11699912 ! ovulation cycle process GO:0022602 41 29 1,000 0,01707519 0,11793676 ! mismatch repair GO:0006298 34 29 1,000 0,01707519 0,11758366 ! telencephalon development GO:0021537 52 29 1,000 0,01707519 0,11723266 ! tissue homeostasis GO:0001894 42 29 1,000 0,01707519 0,11688376 GO:0048871|multicellular organismal homeostasis, ! cellular respiration GO:0045333 107 79 2,000 0,01746841 0,11922058 ! positive regulation of NF-kappaB transcription factor activity GO:0051092 42 30 1,000 0,01821302 0,12393473 ! embryonic skeletal system morphogenesis GO:0048704 42 30 1,000 0,01821302 0,12356914 ! positive regulation of neurogenesis GO:0050769 45 30 1,000 0,01821302 0,1232057 ! ovulation cycle GO:0042698 43 30 1,000 0,01821302 0,1228444 ! regulation of microtubule-based process GO:0032886 58 30 1,000 0,01821302 0,1224852 ! negative regulation of cell activation GO:0050866 44 30 1,000 0,01821302 0,1221281 ! mammary gland development GO:0030879 57 31 1,000 0,01938205 0,1295893 ! mitochondrial electron transport, NADH to ubiquinone GO:0006120 37 31 1,000 0,01938205 0,12921368 ! odontogenesis GO:0042476 50 31 1,000 0,01938205 0,12884023 ! segmentation GO:0035282 41 31 1,000 0,01938205 0,12846893 ! response to mechanical stimulus GO:0009612 43 31 1,000 0,01938205 0,12809976 ! sterol metabolic process GO:0016125 120 84 2,000 0,02053326 0,13531946 ! positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 43 32 1,000 0,02058182 0,13525193 ! negative regulation of DNA metabolic process GO:0051053 48 32 1,000 0,02058182 0,1348666 ! meiosis I GO:0007127 52 32 1,000 0,02058182 0,13448346 ! peripheral nervous system development GO:0007422 53 32 1,000 0,02058182 0,13410248 ! regulation of protein stability GO:0031647 48 32 1,000 0,02058182 0,13372366 ! symbiosis, encompassing mutualism through parasitism GO:0044403 47 32 1,000 0,02058182 0,13334698 ! regulation of membrane potential GO:0042391 128 85 2,000 0,02117943 0,13683339 ! ear morphogenesis GO:0042471 42 33 1,000 0,02181184 0,14052444 ! antigen processing and presentation of peptide antigen GO:0048002 58 33 1,000 0,02181184 0,14013191 ! carbohydrate homeostasis GO:0033500 39 33 1,000 0,02181184 0,13974157 GO:0042593|glucose homeostasis, ! nucleus organization GO:0006997 49 33 1,000 0,02181184 0,1393534 ! female gonad development GO:0008585 49 33 1,000 0,02181184 0,13896738 ! positive regulation of cell development GO:0010720 54 33 1,000 0,02181184 0,13858349 ! negative regulation of hydrolase activity GO:0051346 50 33 1,000 0,02181184 0,13820172 ! androgen receptor signaling pathway GO:0030521 54 33 1,000 0,02181184 0,13782205 ! pyrimidine nucleotide metabolic process GO:0006220 45 33 1,000 0,02181184 0,13744445 ! regulation of smooth muscle cell proliferation GO:0048660 54 34 1,000 0,02307165 0,14498575 ! positive regulation of JAK-STAT cascade GO:0046427 45 34 1,000 0,02307165 0,14459069 ! neuron migration GO:0001764 46 34 1,000 0,02307165 0,14419778 ! female gamete generation GO:0007292 43 34 1,000 0,02307165 0,143807 ! aerobic respiration GO:0009060 47 34 1,000 0,02307165 0,14341833 ! regulation of neurogenesis GO:0050767 153 89 2,000 0,02387495 0,14801185 ! reproductive developmental process GO:0003006 127 89 2,000 0,02387495 0,14761396 ! regulation of intracellular protein transport GO:0033157 59 35 1,000 0,02436078 0,15021391 ! keratinocyte differentiation GO:0030216 47 35 1,000 0,02436078 0,14981226 ! regulation of action potential in neuron GO:0019228 54 35 1,000 0,02436078 0,14941277 ! response to reactive oxygen species GO:0000302 55 36 1,000 0,02567877 0,1570776 ! cellular amide metabolic process GO:0043603 52 36 1,000 0,02567877 0,15666095 ! tissue remodeling GO:0048771 62 36 1,000 0,02567877 0,1562465 ! neural tube development GO:0021915 50 36 1,000 0,02567877 0,15583424 ! development of primary female sexual characteristics GO:0046545 52 36 1,000 0,02567877 0,15542415 GO:0046660|female sex differentiation, ! glycerophospholipid metabolic process GO:0006650 130 92 2,000 0,02601295 0,15703354 ! regulation of cytoskeleton organization GO:0051493 154 93 2,000 0,02674775 0,16104665 ! regulation of tyrosine phosphorylation of STAT protein GO:0042509 54 37 1,000 0,02702518 0,1622922 ! ribonucleoside metabolic process GO:0009119 48 37 1,000 0,02702518 0,16186956 ! regulation of binding GO:0051098 151 95 2,000 0,0282505 0,16876921 ! regulation of T cell proliferation GO:0042129 58 38 1,000 0,02839955 0,16922009 ! mesenchymal cell development GO:0014031 64 38 1,000 0,02839955 0,16878283 GO:0048762|mesenchymal cell differentiation, GO:0060485|mesenchyme development, ! regulation of cellular component biogenesis GO:0044087 158 96 2,000 0,02901842 0,17201643 ! protein maturation GO:0051604 129 96 2,000 0,02901842 0,17157423 ! regulation of G-protein coupled receptor protein signaling pathway GO:0008277 63 39 1,000 0,02980143 0,17575201 ! negative regulation of protein complex disassembly GO:0043242 67 39 1,000 0,02980143 0,17530252 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger GO:0007200 62 39 1,000 0,02980143 0,17485532 ! regulation of transforming growth factor beta receptor signaling pathway GO:0017015 63 39 1,000 0,02980143 0,1744104 ! regulation of epithelial cell proliferation GO:0050678 71 39 1,000 0,02980143 0,17396773 ! multicellular organismal metabolic process GO:0044236 50 39 1,000 0,02980143 0,17352731 ! chromatin remodeling GO:0006338 68 39 1,000 0,02980143 0,1730891 ! regulation of tube size GO:0035150 60 40 1,000 0,03123039 0,18093171 GO:0050880|regulation of blood vessel size, ! positive regulation of response to external stimulus GO:0032103 65 40 1,000 0,03123039 0,18047711 ! detection of stimulus involved in sensory perception GO:0050906 50 40 1,000 0,03123039 0,18002479 ! ATP synthesis coupled electron transport GO:0042773 48 40 1,000 0,03123039 0,17957473 GO:0042775|mitochondrial ATP synthesis coupled electron transport, ! T cell differentiation GO:0030217 65 40 1,000 0,03123039 0,17912691 ! epidermal cell differentiation GO:0009913 53 40 1,000 0,03123039 0,17868132 ! JAK-STAT cascade GO:0007259 53 40 1,000 0,03123039 0,17823794 ! extracellular structure organization GO:0043062 156 99 2,000 0,03138824 0,1786954 ! regulation of T cell differentiation GO:0045580 59 41 1,000 0,03268599 0,18562412 ! biopolymer methylation GO:0043414 62 41 1,000 0,03268599 0,18516692 ! regulation of interferon-alpha biosynthetic process GO:0045354 5 5 0,000 0,03413512 0,19290118 ! negative regulation of protein ubiquitination GO:0031397 7 5 0,000 0,03413512 0,19242838 ! positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 6 5 0,000 0,03413512 0,1919579 ! negative regulation of nucleotide biosynthetic process GO:0030809 7 5 0,000 0,03413512 0,19148971 GO:0030800|negative regulation of cyclic nucleotide metabolic process, GO:0030803|negative regulation of cyclic nucleotide biosynthetic process, ! autophagic vacuole formation GO:0000045 8 5 0,000 0,03413512 0,19102379 ! blood coagulation, extrinsic pathway GO:0007598 9 5 0,000 0,03413512 0,19056014 ! regulation of cGMP metabolic process GO:0030823 6 5 0,000 0,03413512 0,19009874 ! benzene and derivative metabolic process GO:0042537 11 5 0,000 0,03413512 0,18963956 ! sleep GO:0030431 11 5 0,000 0,03413512 0,1891826 ! negative regulation of bone resorption GO:0045779 10 5 0,000 0,03413512 0,18872784 ! nucleotide-sugar transport GO:0015780 8 5 0,000 0,03413512 0,18827525 ! regulation of interferon-beta production GO:0032648 5 5 0,000 0,03413512 0,18782483 GO:0045359|positive regulation of interferon-beta biosynthetic process, GO:0045357|regulation of interferon-beta biosynthetic process, ! regulation of hormone biosynthetic process GO:0046885 7 5 0,000 0,03413512 0,18737656 ! regulation of granulocyte macrophage colony-stimulating factor production GO:0032645 5 5 0,000 0,03413512 0,18693043 GO:0045423|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, GO:0045425|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, ! forebrain regionalization GO:0021871 6 5 0,000 0,03413512 0,18648641 ! tongue development GO:0043586 6 5 0,000 0,03413512 0,1860445 ! DNA catabolic process, exonucleolytic GO:0000738 6 5 0,000 0,03413512 0,18560468 ! cell adhesion mediated by integrin GO:0033627 8 5 0,000 0,03413512 0,18516693 ! short-chain fatty acid metabolic process GO:0046459 7 5 0,000 0,03413512 0,18473125 ! cobalt ion transport GO:0006824 9 5 0,000 0,03413512 0,1842976 ! activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 10 5 0,000 0,03413512 0,18386599 ! SMAD protein complex assembly GO:0007183 9 5 0,000 0,03413512 0,1834364 ! regulation of respiratory gaseous exchange GO:0043576 7 5 0,000 0,03413512 0,18300881 ! protein thiol-disulfide exchange GO:0006467 5 5 0,000 0,03413512 0,18258321 ! receptor guanylyl cyclase signaling pathway GO:0007168 5 5 0,000 0,03413512 0,18215958 ! regulation of cardiac muscle cell proliferation GO:0060043 7 5 0,000 0,03413512 0,18173792 ! embryonic camera-type eye development GO:0031076 8 5 0,000 0,03413512 0,1813182 GO:0048596|embryonic camera-type eye morphogenesis, ! negative regulation of cell-cell adhesion GO:0022408 11 5 0,000 0,03413512 0,18090041 ! positive regulation of cell-cell adhesion GO:0022409 10 5 0,000 0,03413512 0,18048455 ! adaptation of signaling pathway GO:0022401 7 5 0,000 0,03413512 0,1800706 GO:0002029|desensitization of G-protein coupled receptor protein signaling pathway, ! regulation of collagen biosynthetic process GO:0032965 6 5 0,000 0,03413512 0,17965853 ! regulation of mitochondrial membrane permeability GO:0046902 9 5 0,000 0,03413512 0,17924836 ! neurofilament cytoskeleton organization GO:0060052 8 5 0,000 0,03413512 0,17884004 ! positive regulation of histone modification GO:0031058 5 5 0,000 0,03413512 0,17843359 ! malate metabolic process GO:0006108 7 5 0,000 0,03413512 0,17802898 ! transcription from mitochondrial promoter GO:0006390 6 5 0,000 0,03413512 0,1776262 ! behavioral response to pain GO:0048266 7 5 0,000 0,03413512 0,17722524 ! clathrin coat assembly GO:0048268 11 5 0,000 0,03413512 0,17682608 ! phototransduction, visible light GO:0007603 6 5 0,000 0,03413512 0,17642872 ! regulation of dopamine uptake GO:0051584 9 5 0,000 0,03413512 0,17603314 GO:0051580|regulation of neurotransmitter uptake, GO:0051940|regulation of catecholamine uptake during transmission of nerve impulse, ! cerebral cortex radially oriented cell migration GO:0021799 8 5 0,000 0,03413512 0,17563933 ! mating behavior GO:0007617 6 5 0,000 0,03413512 0,17524728 ! metabotropic glutamate receptor signaling pathway GO:0007216 6 5 0,000 0,03413512 0,17485697 ! serotonin receptor signaling pathway GO:0007210 8 5 0,000 0,03413512 0,1744684 ! rhythmic behavior GO:0007622 12 5 0,000 0,03413512 0,17408155 ! copulation GO:0007620 7 5 0,000 0,03413512 0,17369641 ! glial cell fate commitment GO:0021781 12 5 0,000 0,03413512 0,17331298 ! embryonic hemopoiesis GO:0035162 10 5 0,000 0,03413512 0,17293123 ! regulation of potassium ion transport GO:0043266 9 5 0,000 0,03413512 0,17255116 ! regulation of smooth muscle cell differentiation GO:0051150 8 5 0,000 0,03413512 0,17217276 ! apoptotic cell clearance GO:0043277 13 5 0,000 0,03413512 0,17179602 ! lipoprotein particle clearance GO:0034381 9 5 0,000 0,03413512 0,17142092 ! fructose 1,6-bisphosphate metabolic process GO:0030388 6 5 0,000 0,03413512 0,17104745 ! leukocyte tethering or rolling GO:0050901 7 5 0,000 0,03413512 0,17067561 ! response to protozoan GO:0001562 9 5 0,000 0,03413512 0,17030538 ! lymph vessel development GO:0001945 7 5 0,000 0,03413512 0,16993675 ! endochondral ossification GO:0001958 12 5 0,000 0,03413512 0,16956972 GO:0060349|bone morphogenesis, GO:0060350|endochondral bone morphogenesis, ! positive regulation of neurotransmitter secretion GO:0001956 10 5 0,000 0,03413512 0,16920427 ! parathyroid gland development GO:0060017 8 5 0,000 0,03413512 0,16884039 ! regulation of nuclear mRNA splicing, via spliceosome GO:0048024 8 5 0,000 0,03413512 0,16847807 ! anagen GO:0042640 6 5 0,000 0,03413512 0,1681173 ! positive regulation of viral genome replication GO:0045070 8 5 0,000 0,03413512 0,16775808 ! traversing start control point of mitotic cell cycle GO:0007089 11 5 0,000 0,03413512 0,16740038 ! mitotic cell cycle spindle assembly checkpoint GO:0007094 11 5 0,000 0,03413512 0,16704421 GO:0045841|negative regulation of mitotic metaphase/anaphase transition, GO:0051784|negative regulation of nuclear division, ! hydrogen peroxide biosynthetic process GO:0050665 6 5 0,000 0,03413512 0,16668955 ! dermatan sulfate proteoglycan biosynthetic process GO:0050651 7 5 0,000 0,03413512 0,1663364 GO:0050655|dermatan sulfate proteoglycan metabolic process, ! skeletal myofibril assembly GO:0014866 7 5 0,000 0,03413512 0,16598473 ! regulation of systemic arterial blood pressure by endothelin GO:0003100 6 5 0,000 0,03413512 0,16563456 ! peptidyl-lysine modification to hypusine GO:0008612 8 5 0,000 0,03413512 0,16528585 GO:0046516|hypusine metabolic process, ! epithelial cell proliferation GO:0050673 6 5 0,000 0,03413512 0,16493861 ! cardiac muscle fiber development GO:0048739 7 5 0,000 0,03413512 0,16459283 ! regulation of retroviral genome replication GO:0045091 6 5 0,000 0,03413512 0,16424849 ! neutrophil mediated immunity GO:0002446 6 5 0,000 0,03413512 0,16390559 ! induction of apoptosis by oxidative stress GO:0008631 5 5 0,000 0,03413512 0,16356412 ! ovulation GO:0030728 6 5 0,000 0,03413512 0,16322407 ! positive regulation of peptidyl-serine phosphorylation GO:0033138 7 5 0,000 0,03413512 0,16288543 GO:0033135|regulation of peptidyl-serine phosphorylation, ! microvillus organization GO:0032528 7 5 0,000 0,03413512 0,1625482 GO:0030033|microvillus assembly, ! response to pH GO:0009268 9 5 0,000 0,03413512 0,16221235 ! regulation of fibroblast growth factor receptor signaling pathway GO:0040036 10 5 0,000 0,03413512 0,1618779 ! proline biosynthetic process GO:0006561 6 5 0,000 0,03413512 0,16154481 ! endoplasmic reticulum organization GO:0007029 11 5 0,000 0,03413512 0,1612131 ! DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 15 5 0,000 0,03413512 0,16088275 ! positive regulation of interleukin-6 biosynthetic process GO:0045410 6 5 0,000 0,03413512 0,16055374 ! polyol catabolic process GO:0046174 7 5 0,000 0,03413512 0,16022608 GO:0019405|alditol catabolic process, ! polyol biosynthetic process GO:0046173 5 5 0,000 0,03413512 0,15989975 ! melanin biosynthetic process from tyrosine GO:0006583 6 5 0,000 0,03413512 0,15957476 ! regulation of cardiac muscle contraction GO:0055117 5 5 0,000 0,03413512 0,15925107 ! sister chromatid cohesion GO:0007062 9 5 0,000 0,03413512 0,1589287 ! nerve growth factor processing GO:0032455 7 5 0,000 0,03413512 0,15860764 ! urea metabolic process GO:0019627 6 5 0,000 0,03413512 0,15828786 GO:0043604|amide biosynthetic process, GO:0000050|urea cycle, ! response to ATP GO:0033198 6 5 0,000 0,03413512 0,15796938 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 7 5 0,000 0,03413512 0,15765217 ! neutrophil activation GO:0042119 5 5 0,000 0,03413512 0,15733623 ! regulation of angiotensin levels in blood GO:0002002 8 5 0,000 0,03413512 0,15702156 GO:0060177|regulation of angiotensin metabolic process, ! regulation of appetite GO:0032098 5 5 0,000 0,03413512 0,15670814 ! response to food GO:0032094 5 5 0,000 0,03413512 0,15639598 ! regulation of Cdc42 protein signal transduction GO:0032489 7 5 0,000 0,03413512 0,15608505 GO:0043088|regulation of Cdc42 GTPase activity, ! paraxial mesoderm development GO:0048339 9 5 0,000 0,03413512 0,15577536 ! forebrain neuron development GO:0021884 7 5 0,000 0,03413512 0,15546689 ! melanosome organization GO:0032438 7 5 0,000 0,03413512 0,15515964 ! regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 6 5 0,000 0,03413512 0,15485361 ! substrate-bound cell migration, cell extension GO:0006930 5 5 0,000 0,03413512 0,15454878 ! positive regulation of neuroblast proliferation GO:0002052 8 5 0,000 0,03413512 0,15424515 ! cellular polysaccharide catabolic process GO:0044247 5 5 0,000 0,03413512 0,15394271 GO:0009251|glucan catabolic process, ! peptidyl-threonine phosphorylation GO:0018107 14 5 0,000 0,03413512 0,15364145 ! peptidyl-histidine phosphorylation GO:0018106 7 5 0,000 0,03413512 0,15334137 ! nucleoside transport GO:0015858 6 5 0,000 0,03413512 0,15304246 ! nucleoside salvage GO:0043174 7 5 0,000 0,03413512 0,15274471 GO:0006166|purine ribonucleoside salvage, ! attachment of GPI anchor to protein GO:0016255 9 5 0,000 0,03413512 0,15244812 ! antigen processing and presentation of peptide antigen via MHC class II GO:0002495 6 5 0,000 0,03413512 0,15215267 GO:0002478|antigen processing and presentation of exogenous peptide antigen, GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II, ! folic acid transport GO:0015884 9 5 0,000 0,03413512 0,15185837 ! establishment of synaptic specificity at neuromuscular junction GO:0007529 6 5 0,000 0,03413512 0,15156521 ! positive regulation of vasoconstriction GO:0045907 9 5 0,000 0,03413512 0,15127318 ! early endosome to late endosome transport GO:0045022 11 5 0,000 0,03413512 0,15098227 ! maintenance of fidelity during DNA-dependent DNA replication GO:0045005 5 5 0,000 0,03413512 0,15069248 ! depyrimidination GO:0045008 8 5 0,000 0,03413512 0,15040379 ! regulation of synaptic growth at neuromuscular junction GO:0008582 8 5 0,000 0,03413512 0,15011621 ! 5S class rRNA transcription GO:0042791 8 5 0,000 0,03413512 0,14982973 GO:0042797|tRNA transcription from RNA polymerase III promoter, ! lipopolysaccharide biosynthetic process GO:0009103 5 5 0,000 0,03413512 0,14954434 ! regulation of centrosome cycle GO:0046605 7 5 0,000 0,03413512 0,14926004 ! neuronal ion channel clustering GO:0045161 7 5 0,000 0,03413512 0,14897681 ! sodium ion homeostasis GO:0055078 6 5 0,000 0,03413512 0,14869466 ! homeostasis of number of cells within a tissue GO:0048873 9 5 0,000 0,03413512 0,14841357 ! negative regulation of gliogenesis GO:0014014 16 5 0,000 0,03413512 0,14813355 GO:0045686|negative regulation of glial cell differentiation, ! nucleoside monophosphate catabolic process GO:0009125 10 5 0,000 0,03413512 0,14785458 ! monocyte differentiation GO:0030224 8 5 0,000 0,03413512 0,14757665 ! negative regulation of peptide secretion GO:0002792 6 5 0,000 0,03413512 0,14729977 GO:0046676|negative regulation of insulin secretion, ! forebrain morphogenesis GO:0048853 13 5 0,000 0,03413512 0,14702393 ! centrosome duplication GO:0051298 5 5 0,000 0,03413512 0,14674912 ! response to UV-C GO:0010225 6 5 0,000 0,03413512 0,14647534 ! leukemia inhibitory factor signaling pathway GO:0048861 8 5 0,000 0,03413512 0,14620257 ! negative regulation of alpha-beta T cell activation GO:0046636 6 5 0,000 0,03413512 0,14593082 GO:0046639|negative regulation of alpha-beta T cell differentiation, ! cardiac myofibril assembly GO:0055003 7 5 0,000 0,03413512 0,14566007 ! regulation of dendrite development GO:0050773 12 5 0,000 0,03413512 0,14539033 ! peptidyl-arginine modification GO:0018195 7 5 0,000 0,03413512 0,14512159 ! positive regulation of organ growth GO:0046622 6 5 0,000 0,03413512 0,14485384 ! negative regulation of T cell mediated immunity GO:0002710 11 5 0,000 0,03413512 0,14458707 GO:0002707|negative regulation of lymphocyte mediated immunity, ! melanosome transport GO:0032402 8 5 0,000 0,03413512 0,14432129 ! negative regulation of protein kinase B signaling cascade GO:0051898 11 5 0,000 0,03413512 0,14405648 ! regulation of dopamine secretion GO:0014059 12 5 0,000 0,03413512 0,14379264 ! respiratory chain complex IV assembly GO:0008535 9 5 0,000 0,03413512 0,14352976 ! CD4-positive, alpha beta T cell differentiation GO:0043367 7 5 0,000 0,03413512 0,14326785 ! purine deoxyribonucleotide catabolic process GO:0009155 5 5 0,000 0,03413512 0,14300688 ! regulation of interleukin-1 production GO:0032652 7 5 0,000 0,03413512 0,14274687 ! positive regulation of interleukin-4 production GO:0032753 8 5 0,000 0,03413512 0,1424878 GO:0032754|positive regulation of interleukin-5 production, ! base conversion or substitution editing GO:0016553 5 5 0,000 0,03413512 0,14222967 ! positive regulation of Rho GTPase activity GO:0032321 9 5 0,000 0,03413512 0,14197248 ! negative regulation of multicellular organism growth GO:0040015 7 5 0,000 0,03413512 0,14171621 ! histone demethylation GO:0016577 9 5 0,000 0,03413512 0,14146086 ! regulation of myeloid leukocyte mediated immunity GO:0002886 5 5 0,000 0,03413512 0,14120644 ! regulation of sterol transport GO:0032371 7 5 0,000 0,03413512 0,14095293 GO:0032374|regulation of cholesterol transport, ! positive regulation of chemokine production GO:0032722 7 5 0,000 0,03413512 0,14070032 ! enteric nervous system development GO:0048484 8 5 0,000 0,03413512 0,14044862 ! establishment of planar polarity GO:0001736 6 5 0,000 0,03413512 0,14019782 ! positive regulation of mast cell activation GO:0033005 5 5 0,000 0,03413512 0,13994791 ! muscle cell proliferation GO:0033002 8 5 0,000 0,03413512 0,1396989 ! transcription termination GO:0006353 8 5 0,000 0,03413512 0,13945076 ! negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 13 5 0,000 0,03413512 0,13920351 ! plasminogen activation GO:0031639 5 5 0,000 0,03413512 0,13895713 ! positive regulation of blood coagulation GO:0030194 10 5 0,000 0,03413512 0,13871162 ! regulation of muscle cell apoptosis GO:0010660 8 5 0,000 0,03413512 0,13846698 ! energy coupled proton transport, against electrochemical gradient GO:0015988 6 5 0,000 0,03413512 0,1382232 GO:0015991|ATP hydrolysis coupled proton transport, ! regulation of hair follicle development GO:0051797 9 5 0,000 0,03413512 0,13798028 GO:0042634|regulation of hair cycle, ! protein destabilization GO:0031648 6 5 0,000 0,03413512 0,13773821 ! apical protein localization GO:0045176 6 5 0,000 0,03413512 0,13749699 ! negative regulation of osteoblast differentiation GO:0045668 5 5 0,000 0,03413512 0,13725661 ! tetrahydrobiopterin biosynthetic process GO:0006729 5 5 0,000 0,03413512 0,13701707 ! galactolipid metabolic process GO:0019374 7 5 0,000 0,03413512 0,13677836 GO:0006681|galactosylceramide metabolic process, ! porphyrin catabolic process GO:0006787 12 5 0,000 0,03413512 0,13654049 GO:0033015|tetrapyrrole catabolic process, ! nonprotein amino acid metabolic process GO:0019794 9 5 0,000 0,03413512 0,13630344 ! positive regulation of T cell mediated cytotoxicity GO:0001916 9 5 0,000 0,03413512 0,13606721 ! triglyceride catabolic process GO:0019433 6 5 0,000 0,03413512 0,1358318 ! glial cell migration GO:0008347 10 5 0,000 0,03413512 0,1355972 ! regulation of mitochondrial depolarization GO:0051900 9 5 0,000 0,03413512 0,13536341 ! ectodermal gut morphogenesis GO:0048567 5 5 0,000 0,03413512 0,13513043 GO:0007439|ectodermal gut development, ! lymphocyte activation during immune response GO:0002285 9 5 0,000 0,03413512 0,13489825 ! somatic stem cell maintenance GO:0035019 13 5 0,000 0,03413512 0,13466686 ! cerebellar cortex formation GO:0021697 6 5 0,000 0,03413512 0,13443627 ! neural plate development GO:0001840 6 5 0,000 0,03413512 0,13420646 ! positive regulation of blood vessel endothelial cell migration GO:0043536 15 5 0,000 0,03413512 0,13397744 ! regulation of sensory perception GO:0051931 6 5 0,000 0,03413512 0,1337492 GO:0051930|regulation of sensory perception of pain, ! negative regulation of NF-kappaB import into nucleus GO:0042347 9 5 0,000 0,03413512 0,13352173 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0032239 9 5 0,000 0,03413512 0,13329504 GO:0046831|regulation of RNA export from nucleus, ! hemopoietic progenitor cell differentiation GO:0002244 10 5 0,000 0,03413512 0,13306912 ! positive regulation of actin filament bundle formation GO:0032233 12 5 0,000 0,03413512 0,13284396 ! sensory cilium assembly GO:0035058 6 5 0,000 0,03413512 0,13261956 ! activation of phospholipase C activity by dopamine receptor signaling pathway GO:0060158 13 5 0,000 0,03413512 0,13239592 ! release of sequestered calcium ion into cytosol GO:0051209 11 5 0,000 0,03413512 0,13217303 GO:0051282|regulation of sequestering of calcium ion, GO:0051283|negative regulation of sequestering of calcium ion, GO:0060401|cytosolic calcium ion transport, GO:0060402|calcium ion transport into cytosol, ! negative regulation of smooth muscle contraction GO:0045986 9 5 0,000 0,03413512 0,13195089 ! spindle assembly GO:0051225 5 5 0,000 0,03413512 0,1317295 ! ensheathment of axons in the peripheral nervous system GO:0032292 13 5 0,000 0,03413512 0,13150884 GO:0022011|myelination in the peripheral nervous system, ! receptor biosynthetic process GO:0032800 6 5 0,000 0,03413512 0,13128893 ! protein amino acid prenylation GO:0018346 9 5 0,000 0,03413512 0,13106975 ! organ regeneration GO:0031100 7 5 0,000 0,03413512 0,1308513 ! NAD biosynthetic process GO:0009435 7 5 0,000 0,03413512 0,13063358 ! carnitine metabolic process GO:0009437 5 5 0,000 0,03413512 0,13041658 GO:0006577|betaine metabolic process, ! positive regulation of microtubule polymerization GO:0031116 9 5 0,000 0,03413512 0,1302003 ! cellular anion homeostasis GO:0030002 6 5 0,000 0,03413512 0,12998473 GO:0055081|anion homeostasis, ! regulation of nucleocytoplasmic transport GO:0046822 70 42 1,000 0,0341678 0,1298941 ! regulation of JAK-STAT cascade GO:0046425 61 42 1,000 0,0341678 0,12967975 ! cellular component disassembly GO:0022411 64 42 1,000 0,0341678 0,12946611 ! embryonic skeletal system development GO:0048706 56 42 1,000 0,0341678 0,12925318 ! regulation of gene expression, epigenetic GO:0040029 72 42 1,000 0,0341678 0,12904094 ! regulation of cell shape GO:0008360 78 42 1,000 0,0341678 0,1288294 ! G1/S transition of mitotic cell cycle GO:0000082 87 43 1,000 0,03567539 0,13429361 ! neuromuscular process GO:0050905 79 43 1,000 0,03567539 0,13407418 ! activation of caspase activity GO:0006919 65 43 1,000 0,03567539 0,13385546 ! methylation GO:0032259 64 43 1,000 0,03567539 0,13363745 ! glycolysis GO:0006096 53 44 1,000 0,03720835 0,13915317 ! regulation of action potential GO:0001508 71 44 1,000 0,03720835 0,13892727 ! negative regulation of cell migration GO:0030336 92 44 1,000 0,03720835 0,1387021 ! induction of apoptosis by extracellular signals GO:0008624 74 44 1,000 0,03720835 0,13847766 ! regulation of inflammatory response GO:0050727 60 44 1,000 0,03720835 0,13825395 ! detection of abiotic stimulus GO:0009582 58 44 1,000 0,03720835 0,13803096 ! regulation of mast cell proliferation GO:0070666 64 44 1,000 0,03720835 0,13780869 ! positive regulation of cell cycle GO:0045787 77 45 1,000 0,03876625 0,14334786 ! positive regulation of defense response GO:0031349 59 45 1,000 0,03876625 0,14311777 ! regulation of translational initiation GO:0006446 64 45 1,000 0,03876625 0,14288842 ! vascular process in circulatory system GO:0003018 69 45 1,000 0,03876625 0,14265979 ! regulation of protein complex disassembly GO:0043244 77 46 1,000 0,04034868 0,14824596 ! response to UV GO:0009411 75 46 1,000 0,04034868 0,14800953 ! tRNA transcription GO:0009304 11 6 0,000 0,04082218 0,14950797 ! positive regulation of MHC class II biosynthetic process GO:0045348 8 6 0,000 0,04082218 0,14927028 GO:0045346|regulation of MHC class II biosynthetic process, ! positive regulation of protein ubiquitination GO:0031398 8 6 0,000 0,04082218 0,14903334 ! negative regulation of S phase of mitotic cell cycle GO:0045749 7 6 0,000 0,04082218 0,14879715 ! positive regulation of cAMP biosynthetic process GO:0030819 11 6 0,000 0,04082218 0,14856172 GO:0030816|positive regulation of cAMP metabolic process, ! positive regulation of DNA repair GO:0045739 7 6 0,000 0,04082218 0,14832702 ! oligosaccharide biosynthetic process GO:0009312 8 6 0,000 0,04082218 0,14809307 ! cytokinesis during cell cycle GO:0033205 9 6 0,000 0,04082218 0,14785985 ! regulation of tumor necrosis factor biosynthetic process GO:0042534 8 6 0,000 0,04082218 0,14762737 ! chaperone mediated protein folding requiring cofactor GO:0051085 7 6 0,000 0,04082218 0,14739561 ! positive regulation of axon extension GO:0045773 8 6 0,000 0,04082218 0,14716458 ! prostate gland development GO:0030850 9 6 0,000 0,04082218 0,14693428 ! negative regulation of small GTPase mediated signal transduction GO:0051058 10 6 0,000 0,04082218 0,14670469 GO:0046580|negative regulation of Ras protein signal transduction, ! virion attachment to host cell surface receptor GO:0019062 11 6 0,000 0,04082218 0,14647583 ! forebrain neuron differentiation GO:0021879 9 6 0,000 0,04082218 0,14624767 GO:0021872|generation of neurons in the forebrain, ! male meiosis GO:0007140 7 6 0,000 0,04082218 0,14602023 ! regulation of lipid catabolic process GO:0050994 9 6 0,000 0,04082218 0,14579349 ! neutral lipid biosynthetic process GO:0046460 8 6 0,000 0,04082218 0,14556745 GO:0046463|acylglycerol biosynthetic process, ! meiotic prophase I GO:0007128 9 6 0,000 0,04082218 0,14534211 ! N-acetylglucosamine catabolic process GO:0006046 8 6 0,000 0,04082218 0,14511747 GO:0006032|chitin catabolic process, GO:0006030|chitin metabolic process, ! transmembrane receptor protein tyrosine phosphatase signaling pathway GO:0007185 17 6 0,000 0,04082218 0,14489353 ! neuron adhesion GO:0007158 9 6 0,000 0,04082218 0,14467027 ! establishment of tissue polarity GO:0007164 7 6 0,000 0,04082218 0,1444477 ! nucleotide-excision repair, DNA incision GO:0033683 7 6 0,000 0,04082218 0,14422581 ! signal peptide processing GO:0006465 8 6 0,000 0,04082218 0,14400461 ! mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 6 6 0,000 0,04082218 0,14378408 ! mRNA stabilization GO:0048255 15 6 0,000 0,04082218 0,14356423 GO:0043489|RNA stabilization, ! posttranscriptional gene silencing by RNA GO:0035194 12 6 0,000 0,04082218 0,14334505 GO:0016441|posttranscriptional gene silencing, ! protein refolding GO:0042026 13 6 0,000 0,04082218 0,14312653 ! opsonization GO:0008228 8 6 0,000 0,04082218 0,14290868 ! regulation of dopamine metabolic process GO:0042053 9 6 0,000 0,04082218 0,1426915 GO:0042069|regulation of catecholamine metabolic process, ! erythrocyte maturation GO:0043249 6 6 0,000 0,04082218 0,14247497 ! sensory perception of temperature stimulus GO:0050951 10 6 0,000 0,04082218 0,1422591 ! protein amino acid dealkylation GO:0008214 11 6 0,000 0,04082218 0,14204388 GO:0006482|protein amino acid demethylation, ! glucocorticoid metabolic process GO:0008211 7 6 0,000 0,04082218 0,14182931 ! photoreceptor cell development GO:0042461 10 6 0,000 0,04082218 0,14161539 GO:0046530|photoreceptor cell differentiation, ! regulation of odontogenesis GO:0042481 8 6 0,000 0,04082218 0,14140212 ! amyloid precursor protein catabolic process GO:0042987 9 6 0,000 0,04082218 0,14118948 ! mechanosensory behavior GO:0007638 8 6 0,000 0,04082218 0,14097748 ! DNA ligation during DNA repair GO:0051103 9 6 0,000 0,04082218 0,14076612 ! negative regulation of endocytosis GO:0045806 8 6 0,000 0,04082218 0,1405554 ! response to interferon-gamma GO:0034341 12 6 0,000 0,04082218 0,1403453 ! positive regulation of gene expression, epigenetic GO:0045815 12 6 0,000 0,04082218 0,14013583 ! regulation of interleukin-12 biosynthetic process GO:0045075 6 6 0,000 0,04082218 0,13992698 ! negative regulation of viral genome replication GO:0045071 7 6 0,000 0,04082218 0,13971876 ! lipopolysaccharide metabolic process GO:0008653 6 6 0,000 0,04082218 0,13951115 ! spinal cord dorsal/ventral patterning GO:0021513 6 6 0,000 0,04082218 0,13930416 ! activation of MAPKKK activity GO:0000185 10 6 0,000 0,04082218 0,13909778 ! inositol phosphate-mediated signaling GO:0048016 9 6 0,000 0,04082218 0,13889202 ! protein lipoylation GO:0009249 10 6 0,000 0,04082218 0,13868686 ! regulation of transcriptional preinitiation complex assembly GO:0045898 8 6 0,000 0,04082218 0,13848231 ! pigment granule organization GO:0048753 11 6 0,000 0,04082218 0,13827836 ! drug transport GO:0015893 6 6 0,000 0,04082218 0,13807501 ! cysteine metabolic process GO:0006534 7 6 0,000 0,04082218 0,13787225 ! activation of caspase activity by cytochrome c GO:0008635 10 6 0,000 0,04082218 0,13767009 ! regulation of defense response to virus by host GO:0050691 6 6 0,000 0,04082218 0,13746853 ! regulation of isotype switching to IgG isotypes GO:0048302 9 6 0,000 0,04082218 0,13726755 ! histidine metabolic process GO:0006547 6 6 0,000 0,04082218 0,13706716 GO:0009075|histidine family amino acid metabolic process, ! glutamate catabolic process GO:0006538 10 6 0,000 0,04082218 0,13686735 ! mitochondrial respiratory chain complex assembly GO:0033108 8 6 0,000 0,04082218 0,13666813 GO:0010257|NADH dehydrogenase complex assembly, GO:0032981|mitochondrial respiratory chain complex I assembly, ! cell fate commitment involved in the formation of primary germ layers GO:0060795 8 6 0,000 0,04082218 0,13646948 GO:0048333|mesodermal cell differentiation, GO:0001710|mesodermal cell fate commitment, ! glycine catabolic process GO:0006546 9 6 0,000 0,04082218 0,13627141 ! adenohypophysis development GO:0021984 10 6 0,000 0,04082218 0,13607392 ! deoxyribonucleotide biosynthetic process GO:0009263 8 6 0,000 0,04082218 0,135877 ! hyperosmotic response GO:0006972 8 6 0,000 0,04082218 0,13568064 ! microtubule nucleation GO:0007020 10 6 0,000 0,04082218 0,13548486 ! ER overload response GO:0006983 7 6 0,000 0,04082218 0,13528963 ! regulation of interleukin-6 biosynthetic process GO:0045408 7 6 0,000 0,04082218 0,13509497 ! positive regulation of interleukin-8 biosynthetic process GO:0045416 7 6 0,000 0,04082218 0,13490087 ! tetrahydrobiopterin metabolic process GO:0046146 6 6 0,000 0,04082218 0,13470732 ! vascular smooth muscle contraction GO:0014829 10 6 0,000 0,04082218 0,13451433 ! negative regulation of NF-kappaB transcription factor activity GO:0032088 13 6 0,000 0,04082218 0,1343219 ! response to dietary excess GO:0002021 7 6 0,000 0,04082218 0,13413001 ! positive regulation of insulin secretion GO:0032024 8 6 0,000 0,04082218 0,13393867 ! cerebral cortex neuron differentiation GO:0021895 12 6 0,000 0,04082218 0,13374787 ! negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043124 9 6 0,000 0,04082218 0,13355762 ! maintenance of protein location in nucleus GO:0051457 16 6 0,000 0,04082218 0,1333679 ! glycerol ether catabolic process GO:0044269 8 6 0,000 0,04082218 0,13317873 GO:0046464|acylglycerol catabolic process, ! purine salvage GO:0043101 8 6 0,000 0,04082218 0,13299009 ! positive regulation of multicellular organismal metabolic process GO:0044253 7 6 0,000 0,04082218 0,13280199 ! neuron apoptosis GO:0051402 8 6 0,000 0,04082218 0,13261441 ! organic alcohol transport GO:0015850 9 6 0,000 0,04082218 0,13242737 ! positive regulation of nitric-oxide synthase activity GO:0051000 10 6 0,000 0,04082218 0,13224085 ! T cell mediated immunity GO:0002456 12 6 0,000 0,04082218 0,13205486 ! carnitine transport GO:0015879 8 6 0,000 0,04082218 0,13186939 GO:0015838|betaine transport, ! antigen processing and presentation of endogenous peptide antigen GO:0002483 12 6 0,000 0,04082218 0,13168444 GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I, GO:0019883|antigen processing and presentation of endogenous antigen, ! macroautophagy GO:0016236 10 6 0,000 0,04082218 0,13150001 ! regulation of immunoglobulin secretion GO:0051023 6 6 0,000 0,04082218 0,13131609 ! positive regulation of exocytosis GO:0045921 6 6 0,000 0,04082218 0,13113269 ! protein import into mitochondrial inner membrane GO:0045039 6 6 0,000 0,04082218 0,1309498 ! parturition GO:0007567 12 6 0,000 0,04082218 0,13076742 ! negative regulation of translational initiation GO:0045947 7 6 0,000 0,04082218 0,13058554 ! regulation of chromatin assembly or disassembly GO:0001672 11 6 0,000 0,04082218 0,13040417 ! protein ubiquitination during ubiquitin-dependent protein catabolic process GO:0042787 11 6 0,000 0,04082218 0,13022331 ! DNA damage response, signal transduction resulting in transcription GO:0042772 11 6 0,000 0,04082218 0,13004294 GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ! spindle checkpoint GO:0031577 14 6 0,000 0,04082218 0,12986308 ! regulation of collagen metabolic process GO:0010712 7 6 0,000 0,04082218 0,12968371 ! wound healing, spreading of epidermal cells GO:0035313 10 6 0,000 0,04082218 0,12950483 ! regulation of cholesterol biosynthetic process GO:0045540 6 6 0,000 0,04082218 0,12932645 ! deoxyribonucleoside metabolic process GO:0009120 7 6 0,000 0,04082218 0,12914856 ! astrocyte development GO:0014002 14 6 0,000 0,04082218 0,12897116 ! hyaluronan metabolic process GO:0030212 6 6 0,000 0,04082218 0,12879425 ! purine base biosynthetic process GO:0009113 14 6 0,000 0,04082218 0,12861781 ! interaction with symbiont GO:0051702 8 6 0,000 0,04082218 0,12844187 ! anterograde axon cargo transport GO:0008089 8 6 0,000 0,04082218 0,1282664 ! skeletal muscle contraction GO:0003009 6 6 0,000 0,04082218 0,12809141 ! eating behavior GO:0042755 6 6 0,000 0,04082218 0,1279169 ! positive regulation of cytokine production during immune response GO:0002720 8 6 0,000 0,04082218 0,12774286 ! transcription-coupled nucleotide-excision repair GO:0006283 6 6 0,000 0,04082218 0,1275693 ! response to copper ion GO:0046688 9 6 0,000 0,04082218 0,12739621 ! DNA topological change GO:0006265 8 6 0,000 0,04082218 0,12722358 ! response to exogenous dsRNA GO:0043330 8 6 0,000 0,04082218 0,12705143 ! enucleate erythrocyte differentiation GO:0043353 9 6 0,000 0,04082218 0,12687974 ! establishment of melanosome localization GO:0032401 9 6 0,000 0,04082218 0,12670851 ! regulation of interleukin-5 production GO:0032674 9 6 0,000 0,04082218 0,12653774 ! positive regulation of B cell differentiation GO:0045579 9 6 0,000 0,04082218 0,12636744 ! negative regulation of focal adhesion formation GO:0051895 16 6 0,000 0,04082218 0,12619759 ! nucleoside catabolic process GO:0009164 6 6 0,000 0,04082218 0,12602819 ! gas homeostasis GO:0033483 11 6 0,000 0,04082218 0,12585926 ! hair follicle maturation GO:0048820 7 6 0,000 0,04082218 0,12569077 ! negative regulation of T cell differentiation GO:0045581 7 6 0,000 0,04082218 0,12552273 ! phosphatidylinositol biosynthetic process GO:0006661 10 6 0,000 0,04082218 0,12535515 ! Schwann cell development GO:0014044 14 6 0,000 0,04082218 0,12518801 ! purine deoxyribonucleotide metabolic process GO:0009151 6 6 0,000 0,04082218 0,12502131 ! dendrite morphogenesis GO:0048813 9 6 0,000 0,04082218 0,12485506 ! regulation of interleukin-13 production GO:0032656 11 6 0,000 0,04082218 0,12468925 ! phosphatidylserine metabolic process GO:0006658 6 6 0,000 0,04082218 0,12452388 ! regulation of myeloid cell apoptosis GO:0033032 10 6 0,000 0,04082218 0,12435895 ! cell differentiation in hindbrain GO:0021533 8 6 0,000 0,04082218 0,12419445 ! histone ubiquitination GO:0016574 7 6 0,000 0,04082218 0,12403039 ! G2 phase GO:0051319 13 6 0,000 0,04082218 0,12386676 GO:0000085|G2 phase of mitotic cell cycle, ! establishment of chromosome localization GO:0051303 9 6 0,000 0,04082218 0,12370356 GO:0050000|chromosome localization, ! regulation of cell division GO:0051302 8 6 0,000 0,04082218 0,1235408 ! regulation of mast cell activation GO:0033003 6 6 0,000 0,04082218 0,12337846 ! membrane to membrane docking GO:0022614 12 6 0,000 0,04082218 0,12321654 ! positive regulation of natural killer cell mediated immune response to tumor cell GO:0002857 8 6 0,000 0,04082218 0,12305505 GO:0002858|regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, GO:0002855|regulation of natural killer cell mediated immune response to tumor cell, GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, ! regulation of inflammatory response to antigenic stimulus GO:0002861 7 6 0,000 0,04082218 0,12289399 ! negative regulation of oxidoreductase activity GO:0051354 10 6 0,000 0,04082218 0,12273334 ! receptor internalization GO:0031623 9 6 0,000 0,04082218 0,12257311 ! neutrophil homeostasis GO:0001780 6 6 0,000 0,04082218 0,1224133 ! coenzyme A metabolic process GO:0015936 9 6 0,000 0,04082218 0,12225391 ! myeloid dendritic cell activation GO:0001773 10 6 0,000 0,04082218 0,12209493 GO:0043011|myeloid dendritic cell differentiation, ! salivary gland morphogenesis GO:0007435 11 6 0,000 0,04082218 0,12193637 ! protein deubiquitination GO:0016579 8 6 0,000 0,04082218 0,12177822 GO:0070646|protein modification by small protein removal, ! regulation of macrophage activation GO:0043030 11 6 0,000 0,04082218 0,12162047 ! negative regulation of neuroblast proliferation GO:0007406 18 6 0,000 0,04082218 0,12146314 ! peptidyl-histidine modification GO:0018202 9 6 0,000 0,04082218 0,12130621 ! axonal fasciculation GO:0007413 9 6 0,000 0,04082218 0,12114968 ! regulation of myoblast differentiation GO:0045661 8 6 0,000 0,04082218 0,12099356 ! thiamin metabolic process GO:0006772 6 6 0,000 0,04082218 0,12083784 ! regulation of epidermal cell differentiation GO:0045604 7 6 0,000 0,04082218 0,12068253 ! positive regulation of T-helper 1 cell differentiation GO:0045627 7 6 0,000 0,04082218 0,12052761 GO:0045625|regulation of T-helper 1 cell differentiation, ! regulation of viral transcription GO:0046782 8 6 0,000 0,04082218 0,12037308 ! progesterone metabolic process GO:0042448 8 6 0,000 0,04082218 0,12021896 ! aspartate family amino acid catabolic process GO:0009068 7 6 0,000 0,04082218 0,12006522 ! glycolipid catabolic process GO:0019377 13 6 0,000 0,04082218 0,11991188 GO:0046479|glycosphingolipid catabolic process, ! negative regulation of axon extension GO:0030517 13 6 0,000 0,04082218 0,11975893 ! positive regulation of glucose import GO:0046326 6 6 0,000 0,04082218 0,11960638 GO:0010828|positive regulation of glucose transport, ! removal of superoxide radicals GO:0019430 10 6 0,000 0,04082218 0,1194542 ! adult feeding behavior GO:0008343 6 6 0,000 0,04082218 0,11930242 ! regulation of Rac protein signal transduction GO:0035020 8 6 0,000 0,04082218 0,11915102 ! blastocyst growth GO:0001832 15 6 0,000 0,04082218 0,11900001 ! pigment granule transport GO:0051904 12 6 0,000 0,04082218 0,11884937 ! positive regulation of fibrinolysis GO:0051919 7 6 0,000 0,04082218 0,11869912 ! regulation of synaptic transmission, dopaminergic GO:0032225 10 6 0,000 0,04082218 0,11854925 ! catecholamine transport GO:0051937 7 6 0,000 0,04082218 0,11839975 ! organ or tissue specific immune response GO:0002251 7 6 0,000 0,04082218 0,11825064 ! regulation of T cell receptor signaling pathway GO:0050856 8 6 0,000 0,04082218 0,11810189 ! positive regulation of smooth muscle contraction GO:0045987 9 6 0,000 0,04082218 0,11795352 ! negative regulation of B cell activation GO:0050869 9 6 0,000 0,04082218 0,11780553 ! protein prenylation GO:0018342 10 6 0,000 0,04082218 0,1176579 ! negative regulation of synaptic transmission GO:0050805 13 6 0,000 0,04082218 0,11751064 ! positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 13 6 0,000 0,04082218 0,11736376 ! positive regulation of microtubule polymerization or depolymerization GO:0031112 11 6 0,000 0,04082218 0,11721723 ! regulation of microtubule polymerization GO:0031113 11 6 0,000 0,04082218 0,11707108 ! positive regulation of coagulation GO:0050820 11 6 0,000 0,04082218 0,11692529 ! respiratory electron transport chain GO:0022904 59 47 1,000 0,04195524 0,12002122 ! negative regulation of immune system process GO:0002683 73 47 1,000 0,04195524 0,11987213 ! regulation of leukocyte proliferation GO:0070663 71 47 1,000 0,04195524 0,1197234 GO:0050670|regulation of lymphocyte proliferation, GO:0032944|regulation of mononuclear cell proliferation, ! positive regulation of caspase activity GO:0043280 72 48 1,000 0,04358553 0,12422145 GO:0010952|positive regulation of peptidase activity, ! immunoglobulin mediated immune response GO:0016064 66 48 1,000 0,04358553 0,12406771 GO:0019724|B cell mediated immunity, ! regulation of endocytosis GO:0030100 63 48 1,000 0,04358553 0,12391435 ! nuclear export GO:0051168 69 48 1,000 0,04358553 0,12376137 ! regulation of lymphocyte differentiation GO:0045619 69 48 1,000 0,04358553 0,12360877 ! positive regulation of cytokine production GO:0001819 73 48 1,000 0,04358553 0,12345654 ! regulation of intracellular transport GO:0032386 78 49 1,000 0,04523913 0,12798278 ! maintenance of location GO:0051235 84 49 1,000 0,04523913 0,12782555 ! regulation of angiogenesis GO:0045765 94 49 1,000 0,04523913 0,12766871 ! nucleoside monophosphate biosynthetic process GO:0009124 73 49 1,000 0,04523913 0,12751225 ! ear development GO:0043583 72 50 1,000 0,04691566 0,13207591 ! skeletal muscle fiber development GO:0048741 73 50 1,000 0,04691566 0,13191445 ! negative regulation of cytoskeleton organization GO:0051494 84 50 1,000 0,04691566 0,13175338 ! lipid modification GO:0030258 73 50 1,000 0,04691566 0,13159271 ! regulation of multicellular organism growth GO:0040014 65 50 1,000 0,04691566 0,13143243 ! positive regulation of cyclin-dependent protein kinase activity GO:0045737 18 7 0,000 0,04746331 0,13280489 ! positive regulation of membrane protein ectodomain proteolysis GO:0051044 9 7 0,000 0,04746331 0,13264352 ! negative regulation of cellular catabolic process GO:0031330 9 7 0,000 0,04746331 0,13248255 ! negative regulation of lipid biosynthetic process GO:0051055 9 7 0,000 0,04746331 0,13232196 ! regulation of interferon-alpha production GO:0032647 7 7 0,000 0,04746331 0,13216177 ! synaptonemal complex assembly GO:0007130 10 7 0,000 0,04746331 0,13200196 GO:0070193|synaptonemal complex organization, ! glycerol-3-phosphate metabolic process GO:0006072 9 7 0,000 0,04746331 0,13184254 ! negative regulation of transmembrane transport GO:0034763 7 7 0,000 0,04746331 0,1316835 GO:0044070|regulation of anion transport, GO:0002036|regulation of L-glutamate transport, GO:0002037|negative regulation of L-glutamate transport, GO:0051953|negative regulation of amine transport, GO:0051956|negative regulation of amino acid transport, ! neutral lipid catabolic process GO:0046461 9 7 0,000 0,04746331 0,13152484 ! regulation of cellular amine metabolic process GO:0033238 10 7 0,000 0,04746331 0,13136657 ! reproductive behavior GO:0019098 12 7 0,000 0,04746331 0,13120868 ! cellular copper ion homeostasis GO:0006878 9 7 0,000 0,04746331 0,13105117 ! carbohydrate phosphorylation GO:0046835 8 7 0,000 0,04746331 0,13089403 ! oligopeptide transport GO:0006857 11 7 0,000 0,04746331 0,13073727 ! protein amino acid sulfation GO:0006477 9 7 0,000 0,04746331 0,13058089 GO:0051923|sulfation, ! actin-myosin filament sliding GO:0033275 10 7 0,000 0,04746331 0,13042488 GO:0070252|actin-mediated cell contraction, GO:0030049|muscle filament sliding, ! negative regulation of JAK-STAT cascade GO:0046426 15 7 0,000 0,04746331 0,13026924 ! RNA methylation GO:0001510 11 7 0,000 0,04746331 0,13011397 ! pericardium development GO:0060039 8 7 0,000 0,04746331 0,12995907 ! macrophage chemotaxis GO:0048246 10 7 0,000 0,04746331 0,12980454 ! fibril organization GO:0043206 13 7 0,000 0,04746331 0,12965038 ! regulation of gluconeogenesis GO:0006111 7 7 0,000 0,04746331 0,12949658 ! positive regulation of neurotransmitter transport GO:0051590 15 7 0,000 0,04746331 0,12934315 ! lipoprotein transport GO:0042953 9 7 0,000 0,04746331 0,12919008 ! cerebral cortex cell migration GO:0021795 11 7 0,000 0,04746331 0,12903738 ! tachykinin receptor signaling pathway GO:0007217 11 7 0,000 0,04746331 0,12888503 ! regulation of inhibitory postsynaptic membrane potential GO:0060080 9 7 0,000 0,04746331 0,12873304 ! estrogen metabolic process GO:0008210 14 7 0,000 0,04746331 0,12858141 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 13 7 0,000 0,04746331 0,12843014 ! negative regulation of muscle cell differentiation GO:0051148 9 7 0,000 0,04746331 0,12827923 ! chemosensory behavior GO:0007635 9 7 0,000 0,04746331 0,12812866 ! T-helper 1 type immune response GO:0042088 11 7 0,000 0,04746331 0,12797845 ! regulation of response to extracellular stimulus GO:0032104 10 7 0,000 0,04746331 0,1278286 GO:0032107|regulation of response to nutrient levels, ! synaptic transmission, dopaminergic GO:0001963 11 7 0,000 0,04746331 0,12767909 ! leukocyte degranulation GO:0043299 10 7 0,000 0,04746331 0,12752993 ! bile acid and bile salt transport GO:0015721 9 7 0,000 0,04746331 0,12738112 ! reflex GO:0060004 12 7 0,000 0,04746331 0,12723266 ! positive regulation of isotype switching GO:0045830 15 7 0,000 0,04746331 0,12708454 GO:0045911|positive regulation of DNA recombination, ! positive regulation of heart rate GO:0010460 9 7 0,000 0,04746331 0,12693677 ! protein-cofactor linkage GO:0018065 13 7 0,000 0,04746331 0,12678934 ! glycerol ether biosynthetic process GO:0046504 10 7 0,000 0,04746331 0,12664225 ! glycerolipid catabolic process GO:0046503 9 7 0,000 0,04746331 0,1264955 ! positive regulation of chemokine biosynthetic process GO:0045080 8 7 0,000 0,04746331 0,1263491 ! spinal cord patterning GO:0021511 7 7 0,000 0,04746331 0,12620303 ! hemoglobin metabolic process GO:0020027 10 7 0,000 0,04746331 0,1260573 ! vascular endothelial growth factor receptor signaling pathway GO:0048010 10 7 0,000 0,04746331 0,1259119 ! adrenal gland development GO:0030325 17 7 0,000 0,04746331 0,12576684 ! pyrimidine deoxyribonucleotide catabolic process GO:0009223 10 7 0,000 0,04746331 0,12562212 ! regulation of defense response to virus by virus GO:0050690 16 7 0,000 0,04746331 0,12547772 ! outer mitochondrial membrane organization GO:0007008 12 7 0,000 0,04746331 0,12533366 GO:0070096|mitochondrial outer membrane translocase complex assembly, ! nucleobase, nucleoside and nucleotide catabolic process GO:0034656 7 7 0,000 0,04746331 0,12518993 GO:0034655|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, ! proline metabolic process GO:0006560 8 7 0,000 0,04746331 0,12504653 ! endosome organization GO:0007032 10 7 0,000 0,04746331 0,12490346 ! thyroid hormone generation GO:0006590 11 7 0,000 0,04746331 0,12476071 ! regulation of granule cell precursor proliferation GO:0021936 11 7 0,000 0,04746331 0,12461829 GO:0021940|positive regulation of granule cell precursor proliferation, ! regulation of interleukin-8 biosynthetic process GO:0045414 9 7 0,000 0,04746331 0,12447619 ! regulation of pigmentation during development GO:0048070 15 7 0,000 0,04746331 0,12433442 ! phasic smooth muscle contraction GO:0014821 12 7 0,000 0,04746331 0,12419297 ! central nervous system neuron axonogenesis GO:0021955 14 7 0,000 0,04746331 0,12405184 GO:0021952|central nervous system projection neuron axonogenesis, ! positive regulation of activated T cell proliferation GO:0042104 12 7 0,000 0,04746331 0,12391103 ! galactose metabolic process GO:0006012 10 7 0,000 0,04746331 0,12377055 ! vesicle fusion GO:0006906 15 7 0,000 0,04746331 0,12363037 ! intracellular pH reduction GO:0051452 10 7 0,000 0,04746331 0,12349052 GO:0045851|pH reduction, ! asymmetric protein localization GO:0008105 8 7 0,000 0,04746331 0,12335098 ! organ growth GO:0035265 11 7 0,000 0,04746331 0,12321176 ! synaptic transmission, glutamatergic GO:0035249 13 7 0,000 0,04746331 0,12307285 ! positive regulation of mesenchymal cell proliferation GO:0002053 9 7 0,000 0,04746331 0,12293426 ! Rac protein signal transduction GO:0016601 7 7 0,000 0,04746331 0,12279597 ! retinol metabolic process GO:0042572 9 7 0,000 0,04746331 0,122658 ! behavioral fear response GO:0001662 13 7 0,000 0,04746331 0,12252034 GO:0002209|behavioral defense response, ! positive regulation of mitotic cell cycle GO:0045931 11 7 0,000 0,04746331 0,12238298 ! negative regulation of muscle contraction GO:0045932 12 7 0,000 0,04746331 0,12224594 ! rRNA modification GO:0000154 12 7 0,000 0,04746331 0,1221092 ! SRP-dependent cotranslational protein targeting to membrane GO:0006614 13 7 0,000 0,04746331 0,12197276 ! response to UV-B GO:0010224 11 7 0,000 0,04746331 0,12183663 ! G1 DNA damage checkpoint GO:0031571 18 7 0,000 0,04746331 0,1217008 ! protein retention in ER lumen GO:0006621 12 7 0,000 0,04746331 0,12156528 ! intermediate filament organization GO:0045109 11 7 0,000 0,04746331 0,12143006 ! cardiac muscle cell differentiation GO:0055007 12 7 0,000 0,04746331 0,12129513 ! cardiac muscle cell development GO:0055013 9 7 0,000 0,04746331 0,12116051 ! fibrinolysis GO:0042730 9 7 0,000 0,04746331 0,12102619 ! negative regulation of insulin receptor signaling pathway GO:0046627 11 7 0,000 0,04746331 0,12089216 ! regulation of circadian rhythm GO:0042752 11 7 0,000 0,04746331 0,12075843 ! B cell lineage commitment GO:0002326 17 7 0,000 0,04746331 0,120625 ! antigen processing and presentation of exogenous antigen GO:0019884 9 7 0,000 0,04746331 0,12049186 ! positive regulation of production of molecular mediator of immune response GO:0002702 9 7 0,000 0,04746331 0,12035901 ! response to tropane GO:0014073 13 7 0,000 0,04746331 0,12022645 GO:0042220|response to cocaine, GO:0048148|behavioral response to cocaine, ! regulation of fat cell differentiation GO:0045598 9 7 0,000 0,04746331 0,12009419 ! melanosome localization GO:0032400 10 7 0,000 0,04746331 0,11996222 ! positive regulation of systemic arterial blood pressure GO:0003084 9 7 0,000 0,04746331 0,11983054 ! negative regulation of interferon-gamma production GO:0032689 11 7 0,000 0,04746331 0,11969915 ! negative regulation of systemic arterial blood pressure GO:0003085 15 7 0,000 0,04746331 0,11956804 ! sphingomyelin metabolic process GO:0006684 8 7 0,000 0,04746331 0,11943722 ! nucleoside diphosphate metabolic process GO:0009132 8 7 0,000 0,04746331 0,11930669 ! glycosylceramide metabolic process GO:0006677 9 7 0,000 0,04746331 0,11917644 ! mast cell activation GO:0045576 9 7 0,000 0,04746331 0,11904648 ! regulation of focal adhesion formation GO:0051893 17 7 0,000 0,04746331 0,1189168 ! regulation of interleukin-10 production GO:0032653 11 7 0,000 0,04746331 0,1187874 ! positive regulation of tumor necrosis factor production GO:0032760 8 7 0,000 0,04746331 0,11865828 ! positive regulation of monooxygenase activity GO:0032770 11 7 0,000 0,04746331 0,11852945 ! spinal cord motor neuron differentiation GO:0021522 9 7 0,000 0,04746331 0,11840089 ! transcription from RNA polymerase I promoter GO:0006360 12 7 0,000 0,04746331 0,11827261 ! T cell lineage commitment GO:0002360 12 7 0,000 0,04746331 0,11814461 ! positive regulation of immunoglobulin mediated immune response GO:0002891 9 7 0,000 0,04746331 0,11801689 GO:0002714|positive regulation of B cell mediated immunity, ! synaptic vesicle endocytosis GO:0048488 16 7 0,000 0,04746331 0,11788944 ! mitochondrion morphogenesis GO:0070584 11 7 0,000 0,04746331 0,11776227 ! regulation of lipid transport GO:0032368 13 7 0,000 0,04746331 0,11763537 ! response to tumor cell GO:0002347 12 7 0,000 0,04746331 0,11750874 ! positive regulation of interleukin-1 beta secretion GO:0050718 9 7 0,000 0,04746331 0,11738239 ! neuroblast proliferation GO:0007405 13 7 0,000 0,04746331 0,11725631 ! lipopolysaccharide-mediated signaling pathway GO:0031663 9 7 0,000 0,04746331 0,11713049 ! establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 10 7 0,000 0,04746331 0,11700495 ! peptidyl-threonine modification GO:0018210 18 7 0,000 0,04746331 0,11687968 ! diuresis GO:0030146 12 7 0,000 0,04746331 0,11675467 GO:0030147|natriuresis, ! ubiquinone metabolic process GO:0006743 9 7 0,000 0,04746331 0,11662994 GO:0006744|ubiquinone biosynthetic process, GO:0045426|quinone cofactor biosynthetic process, ! positive regulation of epidermis development GO:0045684 11 7 0,000 0,04746331 0,11650547 ! negative regulation of osteoclast differentiation GO:0045671 10 7 0,000 0,04746331 0,11638126 ! positive regulation of leukocyte chemotaxis GO:0002690 14 7 0,000 0,04746331 0,11625732 GO:0002688|regulation of leukocyte chemotaxis, ! positive regulation of T-helper 2 cell differentiation GO:0045630 12 7 0,000 0,04746331 0,11613364 ! negative regulation of transmission of nerve impulse GO:0051970 14 7 0,000 0,04746331 0,11601022 ! melanin biosynthetic process GO:0042438 8 7 0,000 0,04746331 0,11588707 ! regulation of synaptogenesis GO:0051963 10 7 0,000 0,04746331 0,11576418 ! serine family amino acid catabolic process GO:0009071 11 7 0,000 0,04746331 0,11564155 ! dopamine biosynthetic process GO:0042416 15 7 0,000 0,04746331 0,11551918 ! regulation of protein homodimerization activity GO:0043496 15 7 0,000 0,04746331 0,11539706 ! lymph node development GO:0048535 9 7 0,000 0,04746331 0,11527521 ! nicotinamide nucleotide biosynthetic process GO:0019359 9 7 0,000 0,04746331 0,11515361 ! positive regulation of ATPase activity GO:0032781 10 7 0,000 0,04746331 0,11503227 ! negative regulation of viral reproduction GO:0048525 8 7 0,000 0,04746331 0,11491118 ! regulation of T cell mediated cytotoxicity GO:0001914 13 7 0,000 0,04746331 0,11479035 ! endosome to lysosome transport GO:0008333 10 7 0,000 0,04746331 0,11466977 ! ATP catabolic process GO:0006200 10 7 0,000 0,04746331 0,11454944 ! establishment of pigment granule localization GO:0051905 13 7 0,000 0,04746331 0,11442937 ! trophectodermal cell differentiation GO:0001829 8 7 0,000 0,04746331 0,11430955 ! negative regulation of telomere maintenance GO:0032205 9 7 0,000 0,04746331 0,11418998 ! negative regulation of calcium ion transport GO:0051926 9 7 0,000 0,04746331 0,11407066 ! toll-like receptor signaling pathway GO:0002224 7 7 0,000 0,04746331 0,11395159 ! positive regulation of NF-kappaB import into nucleus GO:0042346 12 7 0,000 0,04746331 0,11383276 ! amino sugar catabolic process GO:0046348 9 7 0,000 0,04746331 0,11371419 GO:0006043|glucosamine catabolic process, ! embryonic heart tube development GO:0035050 7 7 0,000 0,04746331 0,11359586 ! retina homeostasis GO:0001895 9 7 0,000 0,04746331 0,11347778 ! negative regulation of nucleotide metabolic process GO:0045980 9 7 0,000 0,04746331 0,11335994 ! B cell receptor signaling pathway GO:0050853 11 7 0,000 0,04746331 0,11324235 ! regulation of growth hormone secretion GO:0060123 11 7 0,000 0,04746331 0,113125 ! regulation of antigen receptor-mediated signaling pathway GO:0050854 11 7 0,000 0,04746331 0,11300789 ! behavioral response to nicotine GO:0035095 11 7 0,000 0,04746331 0,11289102 ! fusion of sperm to egg plasma membrane GO:0007342 8 7 0,000 0,04746331 0,1127744 ! defense response to Gram-negative bacterium GO:0050829 9 7 0,000 0,04746331 0,11265802 ! regulation of cyclin-dependent protein kinase activity GO:0000079 81 51 1,000 0,04861473 0,11527204 ! activation of phospholipase C activity GO:0007202 87 51 1,000 0,04861473 0,11515332 GO:0010863|positive regulation of phospholipase C activity, ! muscle fiber development GO:0048747 74 51 1,000 0,04861473 0,11503485 ! regulation of protein catabolic process GO:0042176 77 51 1,000 0,04861473 0,11491663 ! negative regulation of cell motion GO:0051271 104 51 1,000 0,04861473 0,11479864 ! positive regulation of phospholipase activity GO:0010518 88 52 1,000 0,05033595 0,11874121 ! glycerophospholipid biosynthetic process GO:0046474 75 53 1,000 0,05207893 0,12272699 ! glucose catabolic process GO:0006007 66 54 1,000 0,05384331 0,12675497 ! regulation of phospholipase activity GO:0010517 90 54 1,000 0,05384331 0,12662537 ! DNA catabolic process GO:0006308 67 54 1,000 0,05384331 0,12649602 ! detection of external stimulus GO:0009581 66 54 1,000 0,05384331 0,12636695 ! positive regulation of lipase activity GO:0060193 90 54 1,000 0,05384331 0,12623813 ! negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 13 8 0,000 0,05405885 0,12661441 ! positive regulation of cyclic nucleotide metabolic process GO:0030801 14 8 0,000 0,05405885 0,1264856 GO:0030804|positive regulation of cyclic nucleotide biosynthetic process, GO:0030810|positive regulation of nucleotide biosynthetic process, GO:0045981|positive regulation of nucleotide metabolic process, ! negative regulation of cyclin-dependent protein kinase activity GO:0045736 15 8 0,000 0,05405885 0,12635706 ! axon extension GO:0048675 11 8 0,000 0,05405885 0,12622878 ! 'de novo' posttranslational protein folding GO:0051084 9 8 0,000 0,05405885 0,12610076 ! positive regulation of small GTPase mediated signal transduction GO:0051057 15 8 0,000 0,05405885 0,125973 GO:0046579|positive regulation of Ras protein signal transduction, ! associative learning GO:0008306 15 8 0,000 0,05405885 0,12584549 ! DNA synthesis during DNA repair GO:0000731 9 8 0,000 0,05405885 0,12571825 ! cell proliferation in forebrain GO:0021846 10 8 0,000 0,05405885 0,12559126 ! positive regulation of B cell proliferation GO:0030890 11 8 0,000 0,05405885 0,12546453 ! phosphate transport GO:0006817 10 8 0,000 0,05405885 0,12533805 ! N-glycan processing GO:0006491 12 8 0,000 0,05405885 0,12521183 ! Golgi to endosome transport GO:0006895 16 8 0,000 0,05405885 0,12508586 ! UTP metabolic process GO:0046051 8 8 0,000 0,05405885 0,12496015 GO:0006183|GTP biosynthetic process, GO:0006228|UTP biosynthetic process, ! glycosaminoglycan catabolic process GO:0006027 10 8 0,000 0,05405885 0,12483469 ! prostaglandin biosynthetic process GO:0001516 13 8 0,000 0,05405885 0,12470948 GO:0046457|prostanoid biosynthetic process, ! induction of positive chemotaxis GO:0050930 14 8 0,000 0,05405885 0,12458452 ! neurotransmitter uptake GO:0001504 10 8 0,000 0,05405885 0,12445981 ! Wnt receptor signaling pathway through beta-catenin GO:0060070 14 8 0,000 0,05405885 0,12433535 ! smoothened signaling pathway GO:0007224 8 8 0,000 0,05405885 0,12421114 ! membrane hyperpolarization GO:0060081 10 8 0,000 0,05405885 0,12408717 ! chaperone-mediated protein complex assembly GO:0051131 12 8 0,000 0,05405885 0,12396346 ! amyloid precursor protein metabolic process GO:0042982 12 8 0,000 0,05405885 0,12383999 ! neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 19 8 0,000 0,05405885 0,12371676 ! ganglioside metabolic process GO:0001573 15 8 0,000 0,05405885 0,12359378 ! regulation of mesenchymal cell proliferation GO:0010464 10 8 0,000 0,05405885 0,12347105 ! pseudouridine synthesis GO:0001522 9 8 0,000 0,05405885 0,12334856 ! ribonucleoside triphosphate catabolic process GO:0009203 11 8 0,000 0,05405885 0,12322631 GO:0009207|purine ribonucleoside triphosphate catabolic process, ! positive regulation of interferon-gamma biosynthetic process GO:0045078 8 8 0,000 0,05405885 0,1231043 ! endothelial cell differentiation GO:0045446 14 8 0,000 0,05405885 0,12298254 ! ceramide biosynthetic process GO:0046513 9 8 0,000 0,05405885 0,12286101 ! nerve growth factor receptor signaling pathway GO:0048011 10 8 0,000 0,05405885 0,12273973 ! astrocyte differentiation GO:0048708 16 8 0,000 0,05405885 0,12261869 ! embryonic cranial skeleton morphogenesis GO:0048701 11 8 0,000 0,05405885 0,12249788 ! inner mitochondrial membrane organization GO:0007007 11 8 0,000 0,05405885 0,12237731 ! cytoskeletal anchoring at plasma membrane GO:0007016 18 8 0,000 0,05405885 0,12225698 ! L-phenylalanine metabolic process GO:0006558 8 8 0,000 0,05405885 0,12213688 GO:0006559|L-phenylalanine catabolic process, ! polyamine biosynthetic process GO:0006596 9 8 0,000 0,05405885 0,12201702 ! melanin metabolic process GO:0006582 12 8 0,000 0,05405885 0,1218974 ! embryonic eye morphogenesis GO:0048048 12 8 0,000 0,05405885 0,12177801 ! elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) GO:0051482 12 8 0,000 0,05405885 0,12165885 ! macrophage activation GO:0042116 12 8 0,000 0,05405885 0,12153993 ! regulation of type I interferon production GO:0032479 8 8 0,000 0,05405885 0,12142124 ! multicellular organism growth GO:0035264 14 8 0,000 0,05405885 0,12130278 ! retrograde transport, endosome to Golgi GO:0042147 12 8 0,000 0,05405885 0,12118455 ! regulation of vascular permeability GO:0043114 12 8 0,000 0,05405885 0,12106655 ! regulation of multicellular organismal metabolic process GO:0044246 9 8 0,000 0,05405885 0,12094878 ! neurotransmitter catabolic process GO:0042135 13 8 0,000 0,05405885 0,12083124 ! positive regulation of calcium ion transport into cytosol GO:0010524 9 8 0,000 0,05405885 0,12071393 ! ruffle organization GO:0031529 11 8 0,000 0,05405885 0,12059684 ! osteoblast development GO:0002076 13 8 0,000 0,05405885 0,12047999 ! lens development in camera-type eye GO:0002088 10 8 0,000 0,05405885 0,12036336 ! positive regulation of vasodilation GO:0045909 12 8 0,000 0,05405885 0,12024695 ! intestinal cholesterol absorption GO:0030299 13 8 0,000 0,05405885 0,12013077 ! determination of anterior/posterior axis, embryo GO:0008595 10 8 0,000 0,05405885 0,12001481 GO:0007351|tripartite regional subdivision, ! regulation of Notch signaling pathway GO:0008593 18 8 0,000 0,05405885 0,11989908 ! regulation of smoothened signaling pathway GO:0008589 13 8 0,000 0,05405885 0,11978357 ! Schwann cell differentiation GO:0014037 17 8 0,000 0,05405885 0,11966828 ! chondroitin sulfate biosynthetic process GO:0030206 12 8 0,000 0,05405885 0,11955322 GO:0030204|chondroitin sulfate metabolic process, ! copper ion homeostasis GO:0055070 10 8 0,000 0,05405885 0,11943837 ! brain morphogenesis GO:0048854 20 8 0,000 0,05405885 0,11932375 ! oligodendrocyte development GO:0014003 8 8 0,000 0,05405885 0,11920934 ! segment specification GO:0007379 10 8 0,000 0,05405885 0,11909516 ! positive regulation of myeloid leukocyte differentiation GO:0002763 20 8 0,000 0,05405885 0,11898119 ! cellular extravasation GO:0045123 11 8 0,000 0,05405885 0,11886744 ! peptidyl-asparagine modification GO:0018196 13 8 0,000 0,05405885 0,11875391 GO:0018279|protein amino acid N-linked glycosylation via asparagine, ! pigment granule localization GO:0051875 14 8 0,000 0,05405885 0,1186406 ! thiamin and derivative metabolic process GO:0042723 8 8 0,000 0,05405885 0,1185275 ! snRNA metabolic process GO:0016073 10 8 0,000 0,05405885 0,11841462 GO:0016180|snRNA processing, ! regulation of interleukin-4 production GO:0032673 16 8 0,000 0,05405885 0,11830195 ! regulation of protein kinase B signaling cascade GO:0051896 15 8 0,000 0,05405885 0,11818949 ! nucleoside bisphosphate metabolic process GO:0033865 12 8 0,000 0,05405885 0,11807725 ! regulation of mitochondrial membrane potential GO:0051881 11 8 0,000 0,05405885 0,11796522 ! nucleosome disassembly GO:0006337 12 8 0,000 0,05405885 0,11785341 GO:0032986|protein-DNA complex disassembly, GO:0031498|chromatin disassembly, ! molybdopterin cofactor biosynthetic process GO:0032324 10 8 0,000 0,05405885 0,11774181 GO:0051189|prosthetic group metabolic process, GO:0043545|molybdopterin cofactor metabolic process, GO:0006777|Mo-molybdopterin cofactor biosynthetic process, GO:0019720|Mo-molybdopterin cofactor metabolic process, ! positive regulation of Ras GTPase activity GO:0032320 20 8 0,000 0,05405885 0,11763041 ! protein import into peroxisome matrix GO:0016558 14 8 0,000 0,05405885 0,11751923 ! icosanoid secretion GO:0032309 12 8 0,000 0,05405885 0,11740826 GO:0050482|arachidonic acid secretion, ! induction of an organ GO:0001759 11 8 0,000 0,05405885 0,1172975 ! leukocyte activation during immune response GO:0002366 13 8 0,000 0,05405885 0,11718694 GO:0002263|cell activation during immune response, ! positive regulation of interferon-gamma production GO:0032729 9 8 0,000 0,05405885 0,1170766 ! cerebellum morphogenesis GO:0021587 9 8 0,000 0,05405885 0,11696646 GO:0021696|cerebellar cortex morphogenesis, GO:0021695|cerebellar cortex development, ! intracellular lipid transport GO:0032365 13 8 0,000 0,05405885 0,11685653 ! morphogenesis of a polarized epithelium GO:0001738 9 8 0,000 0,05405885 0,1167468 ! regulation of transcription from RNA polymerase III promoter GO:0006359 10 8 0,000 0,05405885 0,11663729 ! sterol catabolic process GO:0016127 9 8 0,000 0,05405885 0,11652797 GO:0006707|cholesterol catabolic process, ! regulation of immune response to tumor cell GO:0002837 10 8 0,000 0,05405885 0,11641886 GO:0002839|positive regulation of immune response to tumor cell, GO:0002834|regulation of response to tumor cell, GO:0002833|positive regulation of response to biotic stimulus, GO:0002836|positive regulation of response to tumor cell, ! regulation of transcription initiation from RNA polymerase II promoter GO:0060260 11 8 0,000 0,05405885 0,11630996 ! positive regulation of interleukin-1 secretion GO:0050716 10 8 0,000 0,05405885 0,11620126 ! negative regulation of cytokine secretion GO:0050710 12 8 0,000 0,05405885 0,11609276 ! regulation of T-helper 1 type immune response GO:0002825 9 8 0,000 0,05405885 0,11598447 ! prophase GO:0051324 11 8 0,000 0,05405885 0,11587637 ! S phase GO:0051320 8 8 0,000 0,05405885 0,11576848 GO:0000084|S phase of mitotic cell cycle, ! regulation of interleukin-1 beta secretion GO:0050706 11 8 0,000 0,05405885 0,11566079 ! regulation of macrophage differentiation GO:0045649 14 8 0,000 0,05405885 0,1155533 ! neuromuscular process controlling posture GO:0050884 11 8 0,000 0,05405885 0,115446 ! branched chain family amino acid catabolic process GO:0009083 11 8 0,000 0,05405885 0,11533891 ! regulation of synaptic transmission, glutamatergic GO:0051966 16 8 0,000 0,05405885 0,11523202 ! hormone catabolic process GO:0042447 13 8 0,000 0,05405885 0,11512532 ! quaternary ammonium group transport GO:0015697 10 8 0,000 0,05405885 0,11501882 ! myeloid cell homeostasis GO:0002262 8 8 0,000 0,05405885 0,11491252 ! regulation of fibrinolysis GO:0051917 13 8 0,000 0,05405885 0,11480641 ! quinone cofactor metabolic process GO:0042375 10 8 0,000 0,05405885 0,1147005 ! negative regulation of organic acid transport GO:0032891 12 8 0,000 0,05405885 0,11459479 ! pattern recognition receptor signaling pathway GO:0002221 8 8 0,000 0,05405885 0,11448927 ! regulation of calcium ion transport via voltage-gated calcium channel activity GO:0051925 9 8 0,000 0,05405885 0,11438394 ! regulation of synaptic transmission, GABAergic GO:0032228 13 8 0,000 0,05405885 0,11427881 ! negative regulation of blood vessel endothelial cell migration GO:0043537 17 8 0,000 0,05405885 0,11417387 ! pyrimidine nucleotide catabolic process GO:0006244 12 8 0,000 0,05405885 0,11406913 ! negative regulation of DNA replication initiation GO:0032297 9 8 0,000 0,05405885 0,11396457 GO:0000076|DNA replication checkpoint, ! mitochondrion localization GO:0051646 12 8 0,000 0,05405885 0,11386021 ! regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 15 8 0,000 0,05405885 0,11375604 ! nucleoside metabolic process GO:0009116 69 55 1,000 0,0556287 0,11695247 ! multicellular organism reproduction GO:0032504 83 57 1,000 0,05926105 0,12447526 GO:0048609|reproductive process in a multicellular organism, ! camera-type eye development GO:0043010 88 57 1,000 0,05926105 0,12436169 ! gonad development GO:0008406 79 57 1,000 0,05926105 0,12424833 ! telencephalon cell migration GO:0022029 16 9 0,000 0,06060909 0,12695892 ! regulation of epithelial cell differentiation GO:0030856 13 9 0,000 0,06060909 0,1268434 ! pentose-phosphate shunt GO:0006098 12 9 0,000 0,06060909 0,12672809 GO:0006740|NADPH regeneration, ! cell volume homeostasis GO:0006884 13 9 0,000 0,06060909 0,12661299 ! regulation of epidermal growth factor receptor activity GO:0007176 13 9 0,000 0,06060909 0,12649809 GO:0010469|regulation of receptor activity, ! CTP metabolic process GO:0046036 9 9 0,000 0,06060909 0,12638341 GO:0006241|CTP biosynthetic process, GO:0009208|pyrimidine ribonucleoside triphosphate metabolic process, GO:0009209|pyrimidine ribonucleoside triphosphate biosynthetic process, ! positive regulation of GTPase activity GO:0043547 21 9 0,000 0,06060909 0,12626893 ! SMAD protein nuclear translocation GO:0007184 15 9 0,000 0,06060909 0,12615466 ! GTP metabolic process GO:0046039 9 9 0,000 0,06060909 0,12604059 ! elastic fiber assembly GO:0048251 13 9 0,000 0,06060909 0,12592674 ! social behavior GO:0035176 14 9 0,000 0,06060909 0,12581308 ! regulation of activated T cell proliferation GO:0046006 15 9 0,000 0,06060909 0,12569964 ! artery development GO:0060840 19 9 0,000 0,06060909 0,12558639 GO:0048844|artery morphogenesis, ! regulation of histone modification GO:0031056 11 9 0,000 0,06060909 0,12547335 ! response to pain GO:0048265 16 9 0,000 0,06060909 0,12536052 ! protein complex disassembly GO:0043241 17 9 0,000 0,06060909 0,12524789 GO:0043624|cellular protein complex disassembly, ! muscarinic acetylcholine receptor signaling pathway GO:0007213 16 9 0,000 0,06060909 0,12513545 ! regulation of carbohydrate biosynthetic process GO:0043255 12 9 0,000 0,06060909 0,12502323 ! cytoplasmic sequestering of transcription factor GO:0042994 11 9 0,000 0,06060909 0,1249112 ! lung alveolus development GO:0048286 17 9 0,000 0,06060909 0,12479937 ! ciliary or flagellar motility GO:0001539 10 9 0,000 0,06060909 0,12468774 ! negative regulation of striated muscle development GO:0045843 11 9 0,000 0,06060909 0,12457632 ! sphingoid biosynthetic process GO:0046520 11 9 0,000 0,06060909 0,12446509 ! regulation of exit from mitosis GO:0007096 12 9 0,000 0,06060909 0,12435406 ! ventral spinal cord development GO:0021517 11 9 0,000 0,06060909 0,12424322 ! protein targeting to ER GO:0045047 19 9 0,000 0,06060909 0,12413259 ! endoderm development GO:0007492 12 9 0,000 0,06060909 0,12402215 ! glycolipid biosynthetic process GO:0009247 11 9 0,000 0,06060909 0,12391191 GO:0006688|glycosphingolipid biosynthetic process, ! positive regulation of survival gene product expression GO:0045885 13 9 0,000 0,06060909 0,12380186 ! arginine catabolic process GO:0006527 10 9 0,000 0,06060909 0,12369201 ! myeloid leukocyte mediated immunity GO:0002444 11 9 0,000 0,06060909 0,12358236 ! telomere maintenance via telomerase GO:0007004 12 9 0,000 0,06060909 0,12347289 GO:0010833|telomere maintenance via telomere lengthening, ! L-serine metabolic process GO:0006563 13 9 0,000 0,06060909 0,12336363 ! V(D)J recombination GO:0033151 12 9 0,000 0,06060909 0,12325455 ! indolalkylamine metabolic process GO:0006586 14 9 0,000 0,06060909 0,12314567 GO:0042434|indole derivative metabolic process, GO:0042430|indole and derivative metabolic process, ! regulation of phosphoprotein phosphatase activity GO:0043666 18 9 0,000 0,06060909 0,12303698 ! regulation of stress fiber formation GO:0051492 20 9 0,000 0,06060909 0,12292848 ! retinoic acid receptor signaling pathway GO:0048384 15 9 0,000 0,06060909 0,12282017 ! mannose metabolic process GO:0006013 9 9 0,000 0,06060909 0,12271206 ! substrate-bound cell migration GO:0006929 10 9 0,000 0,06060909 0,12260413 ! receptor clustering GO:0043113 15 9 0,000 0,06060909 0,12249639 ! epithelial cell development GO:0002064 10 9 0,000 0,06060909 0,12238885 ! regulation of lipoprotein lipase activity GO:0051004 18 9 0,000 0,06060909 0,12228149 ! retinoic acid metabolic process GO:0042573 11 9 0,000 0,06060909 0,12217432 ! positive regulation of muscle contraction GO:0045933 12 9 0,000 0,06060909 0,12206734 ! positive regulation of translational initiation GO:0045948 10 9 0,000 0,06060909 0,12196054 ! acyl-CoA metabolic process GO:0006637 13 9 0,000 0,06060909 0,12185393 ! positive regulation of peptide secretion GO:0002793 15 9 0,000 0,06060909 0,12174751 ! alpha-beta T cell differentiation GO:0046632 14 9 0,000 0,06060909 0,12164127 ! regulation of insulin receptor signaling pathway GO:0046626 13 9 0,000 0,06060909 0,12153522 ! blastoderm segmentation GO:0007350 11 9 0,000 0,06060909 0,12142935 ! base-excision repair, AP site formation GO:0006285 12 9 0,000 0,06060909 0,12132367 ! DNA ligation GO:0006266 14 9 0,000 0,06060909 0,12121817 ! purine nucleoside triphosphate catabolic process GO:0009146 12 9 0,000 0,06060909 0,12111286 ! response to amine stimulus GO:0014075 13 9 0,000 0,06060909 0,12100772 GO:0001975|response to amphetamine, GO:0010243|response to organic nitrogen, ! synaptic vesicle exocytosis GO:0016079 11 9 0,000 0,06060909 0,12090277 ! erythrocyte development GO:0048821 11 9 0,000 0,06060909 0,120798 ! renal water homeostasis GO:0003091 14 9 0,000 0,06060909 0,12069342 ! postreplication repair GO:0006301 11 9 0,000 0,06060909 0,12058901 ! mRNA cleavage GO:0006379 13 9 0,000 0,06060909 0,12048479 ! hindbrain morphogenesis GO:0021575 12 9 0,000 0,06060909 0,12038074 ! regulation of hormone metabolic process GO:0032350 15 9 0,000 0,06060909 0,12027687 ! regulation of DNA replication initiation GO:0030174 13 9 0,000 0,06060909 0,12017319 ! cellular metabolic compound salvage GO:0043094 11 9 0,000 0,06060909 0,12006968 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 16 9 0,000 0,06060909 0,11996635 GO:0002820|negative regulation of adaptive immune response, ! regulation of interleukin-1 secretion GO:0050704 12 9 0,000 0,06060909 0,1198632 ! positive regulation of erythrocyte differentiation GO:0045648 19 9 0,000 0,06060909 0,11976022 ! acid secretion GO:0046717 14 9 0,000 0,06060909 0,11965742 ! negative regulation of lymphocyte differentiation GO:0045620 11 9 0,000 0,06060909 0,1195548 ! methionine biosynthetic process GO:0009086 10 9 0,000 0,06060909 0,11945235 ! purine base metabolic process GO:0006144 18 9 0,000 0,06060909 0,11935008 ! oocyte differentiation GO:0009994 12 9 0,000 0,06060909 0,11924799 GO:0048599|oocyte development, ! thymus development GO:0048538 15 9 0,000 0,06060909 0,11914607 ! pyridine nucleotide biosynthetic process GO:0019363 11 9 0,000 0,06060909 0,11904432 ! spleen development GO:0048536 15 9 0,000 0,06060909 0,11894274 ! anterior/posterior axis specification GO:0009948 11 9 0,000 0,06060909 0,11884134 ! regulation of RNA splicing GO:0043484 14 9 0,000 0,06060909 0,11874012 ! detection of calcium ion GO:0005513 13 9 0,000 0,06060909 0,11863906 ! blastocyst formation GO:0001825 12 9 0,000 0,06060909 0,11853818 ! establishment or maintenance of apical/basal cell polarity GO:0035088 15 9 0,000 0,06060909 0,11843747 ! natural killer cell mediated immunity GO:0002228 13 9 0,000 0,06060909 0,11833692 GO:0042267|natural killer cell mediated cytotoxicity, ! regulation of amino acid transport GO:0051955 11 9 0,000 0,06060909 0,11823655 ! positive regulation of amine transport GO:0051954 15 9 0,000 0,06060909 0,11813635 ! defense response to Gram-positive bacterium GO:0050830 10 9 0,000 0,06060909 0,11803632 ! prepulse inhibition GO:0060134 14 9 0,000 0,06060909 0,11793646 ! embryonic placenta development GO:0001892 12 9 0,000 0,06060909 0,11783677 ! positive regulation of protein polymerization GO:0032273 15 9 0,000 0,06060909 0,11773724 ! insulin secretion GO:0030073 17 9 0,000 0,06060909 0,11763789 ! response to nicotine GO:0035094 16 9 0,000 0,06060909 0,1175387 ! establishment of cell polarity GO:0030010 12 9 0,000 0,06060909 0,11743968 ! regulation of synapse organization GO:0050807 12 9 0,000 0,06060909 0,11734082 ! localization within membrane GO:0051668 15 9 0,000 0,06060909 0,11724213 ! viral reproductive process GO:0022415 87 58 1,000 0,06110728 0,11810651 ! oxygen and reactive oxygen species metabolic process GO:0006800 77 59 1,000 0,06297308 0,12161047 ! lung development GO:0030324 94 59 1,000 0,06297308 0,12150845 ! nucleoside monophosphate metabolic process GO:0009123 95 59 1,000 0,06297308 0,1214066 ! phosphoinositide metabolic process GO:0030384 87 60 1,000 0,06485807 0,12493599 ! glycerolipid biosynthetic process GO:0045017 85 60 1,000 0,06485807 0,12483144 ! regulation of vesicle-mediated transport GO:0060627 79 60 1,000 0,06485807 0,12472707 ! meiosis GO:0007126 96 61 1,000 0,06676193 0,12828107 GO:0051327|M phase of meiotic cell cycle, ! negative regulation of muscle development GO:0048635 12 10 0,000 0,06711434 0,12885057 ! very-long-chain fatty acid metabolic process GO:0000038 16 10 0,000 0,06711434 0,1287431 ! neuron fate specification GO:0048665 11 10 0,000 0,06711434 0,12863582 ! negative regulation of blood pressure GO:0045776 22 10 0,000 0,06711434 0,12852871 ! thyroid gland development GO:0030878 19 10 0,000 0,06711434 0,12842178 ! regulation of B cell proliferation GO:0030888 15 10 0,000 0,06711434 0,12831503 ! regulation of phosphatase activity GO:0010921 21 10 0,000 0,06711434 0,12820846 ! synapsis GO:0007129 13 10 0,000 0,06711434 0,12810206 GO:0070192|chromosome organization involved in meiosis, ! folic acid and derivative biosynthetic process GO:0009396 10 10 0,000 0,06711434 0,12799584 ! regulation of long-term neuronal synaptic plasticity GO:0048169 23 10 0,000 0,06711434 0,12788979 ! syncytium formation by plasma membrane fusion GO:0000768 13 10 0,000 0,06711434 0,12778392 GO:0007520|myoblast fusion, ! hair follicle morphogenesis GO:0031069 17 10 0,000 0,06711434 0,12767823 ! sulfate transport GO:0008272 12 10 0,000 0,06711434 0,12757271 ! COPI coating of Golgi vesicle GO:0048205 14 10 0,000 0,06711434 0,12746737 GO:0048200|Golgi transport vesicle coating, ! androgen metabolic process GO:0008209 13 10 0,000 0,06711434 0,1273622 ! phospholipid efflux GO:0033700 16 10 0,000 0,06711434 0,1272572 ! positive regulation of transcription factor import into nucleus GO:0042993 20 10 0,000 0,06711434 0,12715237 ! positive regulation of heart contraction GO:0045823 14 10 0,000 0,06711434 0,12704772 ! positive regulation of lipid metabolic process GO:0045834 12 10 0,000 0,06711434 0,12694324 ! negative regulation of cell-matrix adhesion GO:0001953 27 10 0,000 0,06711434 0,12683893 GO:0010812|negative regulation of cell-substrate adhesion, ! negative regulation of lipid metabolic process GO:0045833 14 10 0,000 0,06711434 0,1267348 ! pathogenesis GO:0009405 13 10 0,000 0,06711434 0,12663083 ! regulation of interferon-gamma biosynthetic process GO:0045072 11 10 0,000 0,06711434 0,12652703 ! regulation of chemokine biosynthetic process GO:0045073 12 10 0,000 0,06711434 0,12642341 ! two-component signal transduction system (phosphorelay) GO:0000160 14 10 0,000 0,06711434 0,12631995 ! regulation of S phase of mitotic cell cycle GO:0007090 12 10 0,000 0,06711434 0,12621666 ! platelet-derived growth factor receptor signaling pathway GO:0048008 17 10 0,000 0,06711434 0,12611355 ! regulation of catecholamine secretion GO:0050433 18 10 0,000 0,06711434 0,1260106 ! melanocyte differentiation GO:0030318 15 10 0,000 0,06711434 0,12590781 GO:0050931|pigment cell differentiation, ! glucan biosynthetic process GO:0009250 13 10 0,000 0,06711434 0,1258052 GO:0005978|glycogen biosynthetic process, ! polyamine metabolic process GO:0006595 14 10 0,000 0,06711434 0,12570275 ! reverse cholesterol transport GO:0043691 16 10 0,000 0,06711434 0,12560047 ! response to X-ray GO:0010165 16 10 0,000 0,06711434 0,12549836 ! B cell proliferation GO:0042100 14 10 0,000 0,06711434 0,12539641 ! regulation of sodium ion transport GO:0002028 15 10 0,000 0,06711434 0,12529463 ! forebrain cell migration GO:0021885 17 10 0,000 0,06711434 0,12519301 ! lipid digestion GO:0044241 15 10 0,000 0,06711434 0,12509156 ! phagocytosis, engulfment GO:0006911 20 10 0,000 0,06711434 0,12499027 ! neurotransmitter biosynthetic process GO:0042136 14 10 0,000 0,06711434 0,12488914 ! UV protection GO:0009650 14 10 0,000 0,06711434 0,12478818 ! entry into host cell GO:0030260 20 10 0,000 0,06711434 0,12468738 GO:0044409|entry into host, GO:0051828|entry into other organism during symbiotic interaction, GO:0051806|entry into cell of other organism during symbiotic interaction, GO:0052192|movement in environment of other organism during symbiotic interaction, GO:0052126|movement in host environment, GO:0046718|entry of virus into host cell, ! fear response GO:0042596 16 10 0,000 0,06711434 0,12458675 ! heparan sulfate proteoglycan biosynthetic process GO:0015012 13 10 0,000 0,06711434 0,12448627 ! negative regulation of ossification GO:0030279 19 10 0,000 0,06711434 0,12438596 ! positive regulation vascular endothelial growth factor production GO:0010575 18 10 0,000 0,06711434 0,12428581 ! DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0042771 22 10 0,000 0,06711434 0,12418583 ! regulation of bone resorption GO:0045124 24 10 0,000 0,06711434 0,124086 ! alpha-beta T cell activation GO:0046631 16 10 0,000 0,06711434 0,12398633 ! negative regulation of axonogenesis GO:0050771 23 10 0,000 0,06711434 0,12388682 ! regulation of organ growth GO:0046620 11 10 0,000 0,06711434 0,12378747 ! response to dsRNA GO:0043331 18 10 0,000 0,06711434 0,12368829 ! RNA-dependent DNA replication GO:0006278 13 10 0,000 0,06711434 0,12358926 ! pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 10 10 0,000 0,06711434 0,12349038 ! embryonic axis specification GO:0000578 12 10 0,000 0,06711434 0,12339167 ! regulation of B cell differentiation GO:0045577 16 10 0,000 0,06711434 0,12329312 ! purine ribonucleotide catabolic process GO:0009154 14 10 0,000 0,06711434 0,12319472 ! positive regulation of interleukin-6 production GO:0032755 13 10 0,000 0,06711434 0,12309648 ! fucose catabolic process GO:0019317 16 10 0,000 0,06711434 0,12299839 GO:0042355|L-fucose catabolic process, ! mRNA polyadenylation GO:0006378 18 10 0,000 0,06711434 0,12290046 ! protein sumoylation GO:0016925 12 10 0,000 0,06711434 0,12280269 ! negative regulation of tumor necrosis factor production GO:0032720 14 10 0,000 0,06711434 0,12270507 ! negative regulation of MAPKKK cascade GO:0043409 20 10 0,000 0,06711434 0,12260761 ! zymogen activation GO:0031638 14 10 0,000 0,06711434 0,1225103 ! salivary gland development GO:0007431 22 10 0,000 0,06711434 0,12241315 ! negative regulation of neurological system process GO:0031645 19 10 0,000 0,06711434 0,12231615 ! glutathione biosynthetic process GO:0006750 11 10 0,000 0,06711434 0,1222193 ! positive regulation of acute inflammatory response GO:0002675 14 10 0,000 0,06711434 0,12212261 ! positive regulation of neuron differentiation GO:0045666 12 10 0,000 0,06711434 0,12202607 ! positive regulation of leukocyte migration GO:0002687 23 10 0,000 0,06711434 0,12192968 ! multicellular organismal water homeostasis GO:0050891 15 10 0,000 0,06711434 0,12183345 ! thyroid hormone metabolic process GO:0042403 14 10 0,000 0,06711434 0,12173737 ! positive regulation of viral reproduction GO:0048524 15 10 0,000 0,06711434 0,12164143 ! positive regulation of JNK cascade GO:0046330 14 10 0,000 0,06711434 0,12154565 ! detection of bacterium GO:0016045 10 10 0,000 0,06711434 0,12145002 ! embryonic gut development GO:0048566 11 10 0,000 0,06711434 0,12135454 ! activation of innate immune response GO:0002218 10 10 0,000 0,06711434 0,12125921 GO:0002758|innate immune response-activating signal transduction, ! regulation of actin filament bundle formation GO:0032231 21 10 0,000 0,06711434 0,12116404 ! developmental induction GO:0031128 13 10 0,000 0,06711434 0,121069 GO:0045168|cell-cell signaling involved in cell fate specification, ! T cell receptor signaling pathway GO:0050852 18 10 0,000 0,06711434 0,12097412 ! cytoplasmic sequestering of protein GO:0051220 14 10 0,000 0,06711434 0,12087939 ! regulation of synapse structure and activity GO:0050803 13 10 0,000 0,06711434 0,1207848 ! negative regulation of immune effector process GO:0002698 16 10 0,000 0,06711434 0,12069037 ! respiratory tube development GO:0030323 99 62 1,000 0,06868429 0,12341709 ! lymphocyte mediated immunity GO:0002449 88 62 1,000 0,06868429 0,12332074 ! meiotic cell cycle GO:0051321 97 62 1,000 0,06868429 0,12322455 ! viral reproduction GO:0016032 92 63 1,000 0,07062482 0,12660724 ! regulation of lipase activity GO:0060191 109 63 1,000 0,07062482 0,12650864 ! regulation of actin cytoskeleton organization GO:0032956 97 64 1,000 0,07258318 0,12991542 ! hexose catabolic process GO:0019320 82 64 1,000 0,07258318 0,1298144 ! respiratory system development GO:0060541 100 64 1,000 0,07258318 0,12971353 ! adaptive immune response GO:0002250 94 64 1,000 0,07258318 0,12961282 GO:0002460|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ! rRNA transcription GO:0009303 17 11 0,000 0,07357491 0,13128185 ! respiratory burst GO:0045730 14 11 0,000 0,07357491 0,13118008 ! ER-associated protein catabolic process GO:0030433 14 11 0,000 0,07357491 0,13107847 GO:0006515|misfolded or incompletely synthesized protein catabolic process, ! regulation of membrane protein ectodomain proteolysis GO:0051043 16 11 0,000 0,07357491 0,13097701 ! regulation of nitric-oxide synthase activity GO:0050999 20 11 0,000 0,07357491 0,13087572 ! double-strand break repair via homologous recombination GO:0000724 16 11 0,000 0,07357491 0,13077458 GO:0000725|recombinational repair, ! Golgi vesicle budding GO:0048194 17 11 0,000 0,07357491 0,13067359 ! RNA polyadenylation GO:0043631 19 11 0,000 0,07357491 0,13057276 ! regulation of positive chemotaxis GO:0050926 17 11 0,000 0,07357491 0,13047209 GO:0050927|positive regulation of positive chemotaxis, ! mating GO:0007618 14 11 0,000 0,07357491 0,13037157 ! dopamine receptor signaling pathway GO:0007212 22 11 0,000 0,07357491 0,13027121 ! T cell proliferation GO:0042098 20 11 0,000 0,07357491 0,130171 ! positive regulation of stress-activated protein kinase signaling pathway GO:0070304 17 11 0,000 0,07357491 0,13007095 ! positive regulation of endothelial cell proliferation GO:0001938 18 11 0,000 0,07357491 0,12997105 ! bone resorption GO:0045453 16 11 0,000 0,07357491 0,1298713 ! regulated secretory pathway GO:0045055 14 11 0,000 0,07357491 0,1297717 ! chondroitin sulfate proteoglycan biosynthetic process GO:0050650 18 11 0,000 0,07357491 0,12967226 GO:0050654|chondroitin sulfate proteoglycan metabolic process, ! negative regulation of proteolysis GO:0045861 16 11 0,000 0,07357491 0,12957297 ! pyrimidine deoxyribonucleotide metabolic process GO:0009219 16 11 0,000 0,07357491 0,12947384 ! oligodendrocyte differentiation GO:0048709 14 11 0,000 0,07357491 0,12937485 ! syncytium formation GO:0006949 15 11 0,000 0,07357491 0,12927601 ! ribonucleotide catabolic process GO:0009261 16 11 0,000 0,07357491 0,12917733 ! focal adhesion formation GO:0048041 24 11 0,000 0,07357491 0,1290788 ! mitotic spindle organization GO:0007052 15 11 0,000 0,07357491 0,12898041 ! cellular carbohydrate catabolic process GO:0044275 13 11 0,000 0,07357491 0,12888218 ! regulation of intracellular pH GO:0051453 17 11 0,000 0,07357491 0,1287841 ! membrane protein proteolysis GO:0033619 18 11 0,000 0,07357491 0,12868616 GO:0006509|membrane protein ectodomain proteolysis, ! regulation of calcium ion transport into cytosol GO:0010522 13 11 0,000 0,07357491 0,12858838 ! adult heart development GO:0007512 11 11 0,000 0,07357491 0,12849074 ! chondrocyte differentiation GO:0002062 17 11 0,000 0,07357491 0,12839325 ! actin cytoskeleton reorganization GO:0031532 21 11 0,000 0,07357491 0,12829591 ! temperature homeostasis GO:0001659 16 11 0,000 0,07357491 0,12819871 ! L-glutamate transport GO:0015813 16 11 0,000 0,07357491 0,12810167 GO:0015800|acidic amino acid transport, ! regulation of vascular endothelial growth factor production GO:0010574 19 11 0,000 0,07357491 0,12800477 ! heparan sulfate proteoglycan metabolic process GO:0030201 16 11 0,000 0,07357491 0,12790801 ! protein targeting to peroxisome GO:0006625 20 11 0,000 0,07357491 0,12781141 ! stem cell development GO:0048864 29 11 0,000 0,07357491 0,12771495 GO:0019827|stem cell maintenance, ! protein homotetramerization GO:0051289 18 11 0,000 0,07357491 0,12761863 ! negative regulation of myeloid leukocyte differentiation GO:0002762 15 11 0,000 0,07357491 0,12752246 ! positive regulation of T cell mediated immunity GO:0002711 18 11 0,000 0,07357491 0,12742643 ! vasoconstriction GO:0042310 15 11 0,000 0,07357491 0,12733055 ! nucleoside triphosphate catabolic process GO:0009143 15 11 0,000 0,07357491 0,12723481 ! regulation of interleukin-8 production GO:0032677 17 11 0,000 0,07357491 0,12713922 ! regulation of Rho GTPase activity GO:0032319 18 11 0,000 0,07357491 0,12704377 ! ribosome assembly GO:0042255 13 11 0,000 0,07357491 0,12694846 ! nitric oxide metabolic process GO:0046209 14 11 0,000 0,07357491 0,1268533 GO:0006809|nitric oxide biosynthetic process, ! histone deacetylation GO:0016575 13 11 0,000 0,07357491 0,12675828 ! chromatin silencing GO:0006342 19 11 0,000 0,07357491 0,1266634 ! nucleosome positioning GO:0016584 13 11 0,000 0,07357491 0,12656866 ! T cell homeostasis GO:0043029 20 11 0,000 0,07357491 0,12647407 ! regulation of isotype switching GO:0045191 19 11 0,000 0,07357491 0,12637961 ! regulation of leukocyte migration GO:0002685 24 11 0,000 0,07357491 0,1262853 ! regulation of osteoclast differentiation GO:0045670 15 11 0,000 0,07357491 0,12619113 ! protein-chromophore linkage GO:0018298 13 11 0,000 0,07357491 0,1260971 ! regulation of T-helper 2 cell differentiation GO:0045628 17 11 0,000 0,07357491 0,1260032 ! aromatic amino acid family catabolic process GO:0009074 13 11 0,000 0,07357491 0,12590945 ! serine family amino acid biosynthetic process GO:0009070 13 11 0,000 0,07357491 0,12581584 ! oxygen transport GO:0015671 15 11 0,000 0,07357491 0,12572236 ! male genitalia development GO:0030539 13 11 0,000 0,07357491 0,12562903 ! cholesterol efflux GO:0033344 19 11 0,000 0,07357491 0,12553583 ! digestive tract morphogenesis GO:0048546 15 11 0,000 0,07357491 0,12544277 GO:0048547|gut morphogenesis, GO:0055123|digestive system development, ! biogenic amine catabolic process GO:0042402 21 11 0,000 0,07357491 0,12534985 ! leukocyte mediated cytotoxicity GO:0001909 17 11 0,000 0,07357491 0,12525707 ! negative regulation of glucose import GO:0046325 14 11 0,000 0,07357491 0,12516443 GO:0010829|negative regulation of glucose transport, ! germ cell migration GO:0008354 18 11 0,000 0,07357491 0,12507192 ! regulation of organic acid transport GO:0032890 17 11 0,000 0,07357491 0,12497954 ! defense response to fungus GO:0050832 12 11 0,000 0,07357491 0,12488731 ! mRNA 3'-end processing GO:0031124 19 11 0,000 0,07357491 0,12479521 ! lysogeny GO:0030069 18 11 0,000 0,07357491 0,12470324 GO:0019047|provirus integration, ! actin filament polymerization GO:0030041 17 11 0,000 0,07357491 0,12461142 ! acrosome reaction GO:0007340 13 11 0,000 0,07357491 0,12451972 ! regulation of steroid biosynthetic process GO:0050810 11 11 0,000 0,07357491 0,12442816 ! reproductive structure development GO:0048608 90 65 1,000 0,07455903 0,12599983 ! B cell activation GO:0042113 104 65 1,000 0,07455903 0,12590732 ! protein oligomerization GO:0051259 100 65 1,000 0,07455903 0,12581495 ! regulation of actin filament-based process GO:0032970 99 66 1,000 0,07655204 0,12908336 ! antigen processing and presentation GO:0019882 96 66 1,000 0,07655204 0,12898879 ! regulation of neuron differentiation GO:0045664 107 67 1,000 0,07856189 0,13227844 ! lactation GO:0007595 20 12 0,000 0,07999111 0,13458637 ! reproductive cellular process GO:0048610 14 12 0,000 0,07999111 0,13448799 ! tRNA modification GO:0006400 14 12 0,000 0,07999111 0,13438975 ! negative regulation of cell projection organization GO:0031345 26 12 0,000 0,07999111 0,13429165 ! positive regulation of blood pressure GO:0045777 16 12 0,000 0,07999111 0,1341937 ! 'de novo' protein folding GO:0006458 18 12 0,000 0,07999111 0,13409589 ! dicarboxylic acid transport GO:0006835 22 12 0,000 0,07999111 0,13399823 ! non-recombinational repair GO:0000726 19 12 0,000 0,07999111 0,1339007 GO:0006303|double-strand break repair via nonhomologous end joining, ! phospholipid catabolic process GO:0009395 14 12 0,000 0,07999111 0,13380332 ! peroxisomal transport GO:0043574 21 12 0,000 0,07999111 0,13370608 ! negative regulation of transcription factor import into nucleus GO:0042992 24 12 0,000 0,07999111 0,13360898 ! cytokine biosynthetic process GO:0042089 16 12 0,000 0,07999111 0,13351202 ! auditory receptor cell differentiation GO:0042491 25 12 0,000 0,07999111 0,1334152 ! heart looping GO:0001947 15 12 0,000 0,07999111 0,13331852 ! palate development GO:0060021 15 12 0,000 0,07999111 0,13322199 ! positive regulation of interleukin-2 biosynthetic process GO:0045086 21 12 0,000 0,07999111 0,13312559 ! regulation of skeletal muscle fiber development GO:0048742 20 12 0,000 0,07999111 0,13302933 ! nucleotide-sugar metabolic process GO:0009225 14 12 0,000 0,07999111 0,13293321 ! arginine metabolic process GO:0006525 13 12 0,000 0,07999111 0,13283723 ! glycoprotein catabolic process GO:0006516 19 12 0,000 0,07999111 0,13274139 ! methionine metabolic process GO:0006555 13 12 0,000 0,07999111 0,13264568 ! tyrosine metabolic process GO:0006570 14 12 0,000 0,07999111 0,13255012 ! Golgi organization GO:0007030 18 12 0,000 0,07999111 0,13245469 ! cell-cell junction assembly GO:0007043 18 12 0,000 0,07999111 0,1323594 ! negative regulation of endothelial cell migration GO:0010596 21 12 0,000 0,07999111 0,13226424 ! monoamine transport GO:0015844 13 12 0,000 0,07999111 0,13216923 ! positive regulation of activation of JAK2 kinase activity GO:0010535 12 12 0,000 0,07999111 0,13207435 GO:0010536|positive regulation of activation of Janus kinase activity, GO:0010533|regulation of activation of Janus kinase activity, GO:0010534|regulation of activation of JAK2 kinase activity, GO:0002090|regulation of receptor internalization, GO:0002092|positive regulation of receptor internalization, ! neutral amino acid transport GO:0015804 19 12 0,000 0,07999111 0,1319796 ! L-amino acid transport GO:0015807 20 12 0,000 0,07999111 0,13188499 ! positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 12 0,000 0,07999111 0,13179052 GO:0002717|positive regulation of natural killer cell mediated immunity, ! phosphatidylcholine biosynthetic process GO:0006656 17 12 0,000 0,07999111 0,13169618 ! cotranslational protein targeting to membrane GO:0006613 20 12 0,000 0,07999111 0,13160198 ! pyrimidine nucleoside triphosphate metabolic process GO:0009147 13 12 0,000 0,07999111 0,13150791 ! regulation of interleukin-12 production GO:0032655 16 12 0,000 0,07999111 0,13141397 ! ribosomal large subunit biogenesis GO:0042273 12 12 0,000 0,07999111 0,13132017 ! cerebellum development GO:0021549 13 12 0,000 0,07999111 0,13122651 ! gastrulation with mouth forming second GO:0001702 15 12 0,000 0,07999111 0,13113297 ! histone methylation GO:0016571 15 12 0,000 0,07999111 0,13103958 ! gland morphogenesis GO:0022612 23 12 0,000 0,07999111 0,13094631 ! positive regulation of cytokine secretion GO:0050715 16 12 0,000 0,07999111 0,13085317 ! negative regulation of protein secretion GO:0050709 20 12 0,000 0,07999111 0,13076017 ! response to gamma radiation GO:0010332 20 12 0,000 0,07999111 0,1306673 ! regulation of epidermis development GO:0045682 17 12 0,000 0,07999111 0,13057457 ! intestinal absorption GO:0050892 19 12 0,000 0,07999111 0,13048196 ! glutamine family amino acid biosynthetic process GO:0009084 13 12 0,000 0,07999111 0,13038949 ! cAMP biosynthetic process GO:0006171 20 12 0,000 0,07999111 0,13029714 ! regulation of mRNA stability GO:0043488 27 12 0,000 0,07999111 0,13020493 ! regulation of blood vessel endothelial cell migration GO:0043535 33 12 0,000 0,07999111 0,13011285 ! positive regulation of homeostatic process GO:0032846 15 12 0,000 0,07999111 0,13002089 ! RNA 3'-end processing GO:0031123 20 12 0,000 0,07999111 0,12992907 ! positive regulation of calcium-mediated signaling GO:0050850 17 12 0,000 0,07999111 0,12983738 ! response to cold GO:0009409 14 12 0,000 0,07999111 0,12974581 ! development of primary sexual characteristics GO:0045137 92 68 1,000 0,08058825 0,13062225 ! rhythmic process GO:0048511 105 68 1,000 0,08058825 0,13053026 ! response to drug GO:0042493 108 69 1,000 0,0826308 0,13374443 ! positive regulation of protein complex assembly GO:0031334 19 13 0,000 0,08636324 0,13968738 ! pteridine and derivative biosynthetic process GO:0042559 15 13 0,000 0,08636324 0,13958922 ! cGMP metabolic process GO:0046068 16 13 0,000 0,08636324 0,13949119 GO:0006182|cGMP biosynthetic process, ! regulation of chemokine production GO:0032642 17 13 0,000 0,08636324 0,1393933 ! water transport GO:0006833 17 13 0,000 0,08636324 0,13929555 GO:0042044|fluid transport, ! copper ion transport GO:0006825 15 13 0,000 0,08636324 0,13919794 ! regulation of cell-cell adhesion GO:0022407 27 13 0,000 0,08636324 0,13910046 ! lipid localization GO:0010876 24 13 0,000 0,08636324 0,13900312 GO:0019915|lipid storage, ! Wnt receptor signaling pathway, calcium modulating pathway GO:0007223 15 13 0,000 0,08636324 0,13890591 ! negative regulation of cytokine biosynthetic process GO:0042036 18 13 0,000 0,08636324 0,13880885 ! organelle fusion GO:0048284 28 13 0,000 0,08636324 0,13871191 ! regulation of transmembrane transporter activity GO:0022898 19 13 0,000 0,08636324 0,13861511 GO:0032409|regulation of transporter activity, GO:0032412|regulation of ion transmembrane transporter activity, ! endocrine pancreas development GO:0031018 19 13 0,000 0,08636324 0,13851845 ! negative regulation of protein amino acid phosphorylation GO:0001933 27 13 0,000 0,08636324 0,13842192 ! cell differentiation in spinal cord GO:0021515 16 13 0,000 0,08636324 0,13832553 ! photoreceptor cell maintenance GO:0045494 17 13 0,000 0,08636324 0,13822927 ! response to hexose stimulus GO:0009746 19 13 0,000 0,08636324 0,13813314 GO:0009749|response to glucose stimulus, GO:0034284|response to monosaccharide stimulus, ! glutamate metabolic process GO:0006536 18 13 0,000 0,08636324 0,13803715 ! deoxyribonucleotide catabolic process GO:0009264 16 13 0,000 0,08636324 0,13794129 ! cytokine metabolic process GO:0042107 17 13 0,000 0,08636324 0,13784556 ! NAD metabolic process GO:0019674 21 13 0,000 0,08636324 0,13774997 ! exocrine system development GO:0035272 27 13 0,000 0,08636324 0,13765451 ! negative regulation of mitotic cell cycle GO:0045930 23 13 0,000 0,08636324 0,13755918 ! bone mineralization GO:0030282 15 13 0,000 0,08636324 0,13746398 ! regulation of exocytosis GO:0017157 17 13 0,000 0,08636324 0,13736892 ! intermediate filament cytoskeleton organization GO:0045104 23 13 0,000 0,08636324 0,13727399 ! regulation of cytokine production during immune response GO:0002718 18 13 0,000 0,08636324 0,13717918 ! regulation of natural killer cell mediated immunity GO:0002715 19 13 0,000 0,08636324 0,13708451 GO:0042269|regulation of natural killer cell mediated cytotoxicity, ! regulation of DNA repair GO:0006282 15 13 0,000 0,08636324 0,13698997 ! negative regulation of protein import into nucleus GO:0042308 25 13 0,000 0,08636324 0,13689556 ! positive regulation of protein import into nucleus GO:0042307 23 13 0,000 0,08636324 0,13680128 ! genitalia development GO:0048806 15 13 0,000 0,08636324 0,13670713 ! regulation of cellular pH GO:0030641 20 13 0,000 0,08636324 0,13661311 ! regulation of monooxygenase activity GO:0032768 26 13 0,000 0,08636324 0,13651922 ! cellular pigmentation GO:0033059 24 13 0,000 0,08636324 0,13642545 ! tissue regeneration GO:0042246 21 13 0,000 0,08636324 0,13633182 ! cofactor transport GO:0051181 19 13 0,000 0,08636324 0,13623831 ! NADP metabolic process GO:0006739 18 13 0,000 0,08636324 0,13614493 ! neuromuscular synaptic transmission GO:0007274 20 13 0,000 0,08636324 0,13605168 ! regulation of acute inflammatory response GO:0002673 19 13 0,000 0,08636324 0,13595856 ! positive regulation of T-helper cell differentiation GO:0045624 19 13 0,000 0,08636324 0,13586557 ! gas transport GO:0015669 18 13 0,000 0,08636324 0,1357727 ! regulation of RNA stability GO:0043487 28 13 0,000 0,08636324 0,13567996 ! heme biosynthetic process GO:0006783 20 13 0,000 0,08636324 0,13558734 ! regulation of axon extension GO:0030516 23 13 0,000 0,08636324 0,13549486 ! positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 22 13 0,000 0,08636324 0,13540249 ! lymphocyte homeostasis GO:0002260 24 13 0,000 0,08636324 0,13531026 ! positive regulation of calcium ion transport GO:0051928 14 13 0,000 0,08636324 0,13521815 GO:0043270|positive regulation of ion transport, ! L-fucose metabolic process GO:0042354 20 13 0,000 0,08636324 0,13512616 ! regulation of NF-kappaB import into nucleus GO:0042345 23 13 0,000 0,08636324 0,1350343 ! regulation of calcium-mediated signaling GO:0050848 18 13 0,000 0,08636324 0,13494257 ! leukocyte mediated immunity GO:0002443 99 71 1,000 0,0867632 0,13547547 ! lymphocyte differentiation GO:0030098 113 71 1,000 0,0867632 0,13538356 ! monosaccharide catabolic process GO:0046365 91 71 1,000 0,0867632 0,13529177 ! response to hypoxia GO:0001666 132 72 1,000 0,08885244 0,13845569 ! negative regulation of organelle organization GO:0010639 115 72 1,000 0,08885244 0,13836195 ! negative regulation of transport GO:0051051 116 73 1,000 0,09095661 0,14154277 ! regulation of blood pressure GO:0008217 107 73 1,000 0,09095661 0,14144706 ! regulation of skeletal muscle tissue development GO:0048641 22 14 0,000 0,0926916 0,14404775 ! G1 phase of mitotic cell cycle GO:0000080 23 14 0,000 0,0926916 0,14395049 ! superoxide anion generation GO:0042554 18 14 0,000 0,0926916 0,14385336 ! neuron maturation GO:0042551 21 14 0,000 0,0926916 0,14375636 ! regulation of S phase GO:0033261 18 14 0,000 0,0926916 0,14365949 ! regulation of lipid biosynthetic process GO:0046890 16 14 0,000 0,0926916 0,14356274 ! myotube differentiation GO:0014902 21 14 0,000 0,0926916 0,14346613 ! negative regulation of bone remodeling GO:0046851 26 14 0,000 0,0926916 0,14336965 ! heterophilic cell adhesion GO:0007157 29 14 0,000 0,0926916 0,1432733 ! inositol metabolic process GO:0006020 20 14 0,000 0,0926916 0,14317708 ! aminoglycan catabolic process GO:0006026 18 14 0,000 0,0926916 0,14308099 ! vesicle targeting, to, from or within Golgi GO:0048199 18 14 0,000 0,0926916 0,14298503 ! cardiac muscle contraction GO:0060048 23 14 0,000 0,0926916 0,14288919 ! gene silencing by RNA GO:0031047 20 14 0,000 0,0926916 0,14279349 ! response to cAMP GO:0051591 19 14 0,000 0,0926916 0,14269791 ! startle response GO:0001964 21 14 0,000 0,0926916 0,14260246 ! negative regulation of endothelial cell proliferation GO:0001937 29 14 0,000 0,0926916 0,14250714 ! negative regulation of gene expression, epigenetic GO:0045814 23 14 0,000 0,0926916 0,14241194 ! activation of MAPKK activity GO:0000186 21 14 0,000 0,0926916 0,14231687 ! regulation of defense response to virus GO:0050688 24 14 0,000 0,0926916 0,14222193 ! epidermis morphogenesis GO:0048730 29 14 0,000 0,0926916 0,14212712 ! glycine metabolic process GO:0006544 22 14 0,000 0,0926916 0,14203243 ! pituitary gland development GO:0021983 23 14 0,000 0,0926916 0,14193787 ! cellular response to starvation GO:0009267 21 14 0,000 0,0926916 0,14184343 ! lysosomal transport GO:0007041 20 14 0,000 0,0926916 0,14174912 ! regulation of heart rate GO:0002027 23 14 0,000 0,0926916 0,14165493 ! preassembly of GPI anchor in ER membrane GO:0016254 17 14 0,000 0,0926916 0,14156087 ! embryo implantation GO:0007566 27 14 0,000 0,0926916 0,14146694 ! positive regulation of specific transcription from RNA polymerase II promoter GO:0010552 21 14 0,000 0,0926916 0,14137313 ! G1/S transition checkpoint GO:0031575 33 14 0,000 0,0926916 0,14127944 ! purine nucleoside monophosphate metabolic process GO:0009126 21 14 0,000 0,0926916 0,14118588 GO:0009127|purine nucleoside monophosphate biosynthetic process, GO:0009168|purine ribonucleoside monophosphate biosynthetic process, GO:0009167|purine ribonucleoside monophosphate metabolic process, ! intermediate filament-based process GO:0045103 24 14 0,000 0,0926916 0,14109244 ! axon cargo transport GO:0008088 27 14 0,000 0,0926916 0,14099912 ! positive regulation of axonogenesis GO:0050772 19 14 0,000 0,0926916 0,14090593 ! DNA unwinding during replication GO:0006268 21 14 0,000 0,0926916 0,14081286 ! positive regulation of CD4-positive, alpha beta T cell differentiation GO:0043372 20 14 0,000 0,0926916 0,14071992 ! mRNA splice site selection GO:0006376 26 14 0,000 0,0926916 0,1406271 ! regulation of T-helper 2 type immune response GO:0002828 21 14 0,000 0,0926916 0,14053439 ! negative regulation of inflammatory response GO:0050728 16 14 0,000 0,0926916 0,14044182 ! negative regulation of blood coagulation GO:0030195 19 14 0,000 0,0926916 0,14034936 ! sphingolipid catabolic process GO:0030149 23 14 0,000 0,0926916 0,14025702 GO:0046466|membrane lipid catabolic process, ! water homeostasis GO:0030104 24 14 0,000 0,0926916 0,14016481 ! synaptic transmission, cholinergic GO:0007271 21 14 0,000 0,0926916 0,14007272 ! regulation of erythrocyte differentiation GO:0045646 27 14 0,000 0,0926916 0,13998075 ! muscle maintenance GO:0046716 19 14 0,000 0,0926916 0,1398889 ! C21-steroid hormone biosynthetic process GO:0006700 15 14 0,000 0,0926916 0,13979716 ! activation of NF-kappaB-inducing kinase activity GO:0007250 20 14 0,000 0,0926916 0,13970555 ! regulation of ATPase activity GO:0043462 18 14 0,000 0,0926916 0,13961406 ! catecholamine biosynthetic process GO:0042423 23 14 0,000 0,0926916 0,13952269 ! cell killing GO:0001906 20 14 0,000 0,0926916 0,13943144 ! cilium assembly GO:0042384 20 14 0,000 0,0926916 0,13934031 ! peptide hormone secretion GO:0030072 23 14 0,000 0,0926916 0,1392493 ! phospholipid biosynthetic process GO:0008654 102 74 1,000 0,09307543 0,13973466 ! response to oxygen levels GO:0070482 137 74 1,000 0,09307543 0,1396435 ! blood coagulation GO:0007596 116 75 1,000 0,09520859 0,14275082 GO:0050817|coagulation, ! regulation of cell morphogenesis GO:0022604 140 76 1,000 0,0973558 0,14587514 ! regulation of protein transport GO:0051223 114 76 1,000 0,0973558 0,14578017 GO:0070201|regulation of establishment of protein localization, ! regulation of protein ubiquitination GO:0031396 19 15 0,000 0,09897648 0,14811054 ! metencephalon development GO:0022037 19 15 0,000 0,09897648 0,14801424 ! sulfur amino acid biosynthetic process GO:0000097 17 15 0,000 0,09897648 0,14791807 ! negative regulation of hormone secretion GO:0046888 20 15 0,000 0,09897648 0,14782202 ! negative regulation of cell cycle process GO:0010948 24 15 0,000 0,09897648 0,14772609 ! embryonic hindlimb morphogenesis GO:0035116 25 15 0,000 0,09897648 0,14763029 ! regulation of neurotransmitter secretion GO:0046928 26 15 0,000 0,09897648 0,14753461 ! regulation of excitatory postsynaptic membrane potential GO:0060079 25 15 0,000 0,09897648 0,14743906 ! bile acid metabolic process GO:0008206 22 15 0,000 0,09897648 0,14734363 ! regulation of muscle cell differentiation GO:0051147 24 15 0,000 0,09897648 0,14724832 ! adult walking behavior GO:0007628 25 15 0,000 0,09897648 0,14715314 ! isoprenoid biosynthetic process GO:0008299 21 15 0,000 0,09897648 0,14705808 ! regulation of interleukin-2 biosynthetic process GO:0045076 25 15 0,000 0,09897648 0,14696314 ! myoblast differentiation GO:0045445 27 15 0,000 0,09897648 0,14686833 ! centrosome cycle GO:0007098 16 15 0,000 0,09897648 0,14677363 ! positive regulation of proteolysis GO:0045862 19 15 0,000 0,09897648 0,14667906 ! cardiac muscle tissue development GO:0048738 23 15 0,000 0,09897648 0,14658461 ! response to osmotic stress GO:0006970 22 15 0,000 0,09897648 0,14649029 ! vesicle coating GO:0006901 25 15 0,000 0,09897648 0,14639608 ! regulation of the force of heart contraction GO:0002026 21 15 0,000 0,09897648 0,146302 ! DNA integration GO:0015074 22 15 0,000 0,09897648 0,14620803 ! peptidyl-serine phosphorylation GO:0018105 23 15 0,000 0,09897648 0,14611419 ! peptide secretion GO:0002790 27 15 0,000 0,09897648 0,14602046 ! embryonic digit morphogenesis GO:0042733 18 15 0,000 0,09897648 0,14592686 ! regulation of vasodilation GO:0042312 24 15 0,000 0,09897648 0,14583338 ! regulation of T cell mediated immunity GO:0002709 26 15 0,000 0,09897648 0,14574002 ! neuron recognition GO:0008038 22 15 0,000 0,09897648 0,14564677 ! cellular amino acid derivative catabolic process GO:0042219 27 15 0,000 0,09897648 0,14555365 ! negative regulation of tissue remodeling GO:0034104 27 15 0,000 0,09897648 0,14546064 ! peptide biosynthetic process GO:0043043 19 15 0,000 0,09897648 0,14536776 ! biomineral formation GO:0031214 18 15 0,000 0,09897648 0,14527499 ! folic acid and derivative metabolic process GO:0006760 17 15 0,000 0,09897648 0,14518234 ! regulation of T-helper cell differentiation GO:0045622 23 15 0,000 0,09897648 0,14508981 ! aspartate family amino acid biosynthetic process GO:0009067 16 15 0,000 0,09897648 0,14499739 ! dopamine metabolic process GO:0042417 30 15 0,000 0,09897648 0,1449051 ! organic cation transport GO:0015695 19 15 0,000 0,09897648 0,14481292 ! porphyrin biosynthetic process GO:0006779 22 15 0,000 0,09897648 0,14472085 GO:0033014|tetrapyrrole biosynthetic process, ! positive regulation of neuron apoptosis GO:0043525 29 15 0,000 0,09897648 0,14462891 ! defense response to virus GO:0051607 27 15 0,000 0,09897648 0,14453708 ! peptide hormone processing GO:0016486 19 15 0,000 0,09897648 0,14444537 ! cholesterol metabolic process GO:0008203 109 77 1,000 0,09951676 0,14514176 ! gland development GO:0048732 148 77 1,000 0,09951676 0,14504978 ! sex differentiation GO:0007548 105 77 1,000 0,09951676 0,14495792 ! protein ubiquitination GO:0016567 125 77 1,000 0,09951676 0,14486617 ! one-carbon metabolic process GO:0006730 110 77 1,000 0,09951676 0,14477454 ! oxidative phosphorylation GO:0006119 105 79 1,000 0,10387879 0,15102479 ! T cell activation GO:0042110 134 79 1,000 0,10387879 0,15092939 ! protein secretion GO:0009306 27 16 0,000 0,10521818 0,15277893 ! hormone secretion GO:0046879 25 16 0,000 0,10521818 0,15268254 ! bone remodeling GO:0046849 24 16 0,000 0,10521818 0,15258627 ! endothelial cell migration GO:0043542 22 16 0,000 0,10521818 0,15249012 ! protein amino acid deacetylation GO:0006476 20 16 0,000 0,10521818 0,1523941 ! positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 20 16 0,000 0,10521818 0,15229819 ! positive regulation of receptor-mediated endocytosis GO:0048260 18 16 0,000 0,10521818 0,15220241 ! glial cell development GO:0021782 24 16 0,000 0,10521818 0,15210674 ! patterning of blood vessels GO:0001569 24 16 0,000 0,10521818 0,1520112 ! cellular response to hydrogen peroxide GO:0070301 21 16 0,000 0,10521818 0,15191577 GO:0042744|hydrogen peroxide catabolic process, ! mitotic chromosome condensation GO:0007076 25 16 0,000 0,10521818 0,15182047 ! protein polyubiquitination GO:0000209 26 16 0,000 0,10521818 0,15172528 ! complement activation, alternative pathway GO:0006957 16 16 0,000 0,10521818 0,15163022 ! cellular response to unfolded protein GO:0034620 19 16 0,000 0,10521818 0,15153527 GO:0030968|endoplasmic reticulum unfolded protein response, ! fructose metabolic process GO:0006000 20 16 0,000 0,10521818 0,15144044 ! regulation of protein binding GO:0043393 27 16 0,000 0,10521818 0,15134573 ! NLS-bearing substrate import into nucleus GO:0006607 33 16 0,000 0,10521818 0,15125114 ! negative regulation of immune response GO:0050777 28 16 0,000 0,10521818 0,15115667 ! nucleotide-excision repair, DNA gap filling GO:0006297 20 16 0,000 0,10521818 0,15106231 ! DNA replication initiation GO:0006270 25 16 0,000 0,10521818 0,15096807 ! regulation of steroid metabolic process GO:0019218 21 16 0,000 0,10521818 0,15087396 ! regulation of CD4-positive, alpha beta T cell differentiation GO:0043370 24 16 0,000 0,10521818 0,15077995 ! ribosomal small subunit biogenesis GO:0042274 18 16 0,000 0,10521818 0,15068607 ! diencephalon development GO:0021536 25 16 0,000 0,10521818 0,1505923 ! neural crest cell migration GO:0001755 24 16 0,000 0,10521818 0,15049865 ! G1 phase GO:0051318 27 16 0,000 0,10521818 0,15040511 ! neutrophil chemotaxis GO:0030593 21 16 0,000 0,10521818 0,15031169 ! protein localization in mitochondrion GO:0070585 22 16 0,000 0,10521818 0,15021839 GO:0006626|protein targeting to mitochondrion, ! detection of biotic stimulus GO:0009595 19 16 0,000 0,10521818 0,1501252 ! steroid catabolic process GO:0006706 22 16 0,000 0,10521818 0,15003213 ! positive regulation of leukocyte mediated cytotoxicity GO:0001912 22 16 0,000 0,10521818 0,14993917 ! aromatic compound biosynthetic process GO:0019438 18 16 0,000 0,10521818 0,14984633 ! sperm-egg recognition GO:0035036 16 16 0,000 0,10521818 0,1497536 GO:0007339|binding of sperm to zona pellucida, ! antigen receptor-mediated signaling pathway GO:0050851 26 16 0,000 0,10521818 0,14966099 ! inner ear receptor cell differentiation GO:0060113 30 16 0,000 0,10521818 0,14956849 ! alcohol catabolic process GO:0046164 104 80 1,000 0,10607929 0,15069943 ! forebrain development GO:0030900 131 80 1,000 0,10607929 0,1506064 ! hemostasis GO:0007599 125 81 1,000 0,10829241 0,15365364 ! regulation of cell cycle process GO:0010564 122 81 1,000 0,10829241 0,1535589 ! detection of stimulus GO:0051606 108 82 1,000 0,11051787 0,15661805 ! oligosaccharide metabolic process GO:0009311 26 17 0,000 0,111417 0,15779502 ! positive regulation of cell killing GO:0031343 24 17 0,000 0,111417 0,15769791 ! negative regulation of defense response GO:0031348 19 17 0,000 0,111417 0,15760093 ! positive regulation of hormone secretion GO:0046887 24 17 0,000 0,111417 0,15750406 ! phosphatidylinositol metabolic process GO:0046488 22 17 0,000 0,111417 0,15740732 ! glycerol metabolic process GO:0006071 20 17 0,000 0,111417 0,15731069 ! 2'-deoxyribonucleotide metabolic process GO:0009394 22 17 0,000 0,111417 0,15721418 GO:0019692|deoxyribose phosphate metabolic process, ! zinc ion transport GO:0006829 20 17 0,000 0,111417 0,15711779 ! phosphatidylcholine metabolic process GO:0046470 22 17 0,000 0,111417 0,15702151 ! signal complex assembly GO:0007172 29 17 0,000 0,111417 0,15692536 ! retrograde vesicle-mediated transport, Golgi to ER GO:0006890 24 17 0,000 0,111417 0,15682932 ! intra-Golgi vesicle-mediated transport GO:0006891 26 17 0,000 0,111417 0,1567334 ! positive regulation of nucleocytoplasmic transport GO:0046824 27 17 0,000 0,111417 0,1566376 ! glycosaminoglycan biosynthetic process GO:0006024 26 17 0,000 0,111417 0,15654191 ! memory GO:0007613 25 17 0,000 0,111417 0,15644634 ! keratinization GO:0031424 17 17 0,000 0,111417 0,15635089 ! negative regulation of ion transport GO:0043271 20 17 0,000 0,111417 0,15625556 ! retinoid metabolic process GO:0001523 22 17 0,000 0,111417 0,15616034 GO:0016101|diterpenoid metabolic process, ! regulation of viral genome replication GO:0045069 24 17 0,000 0,111417 0,15606523 ! regulation of striated muscle contraction GO:0006942 20 17 0,000 0,111417 0,15597024 ! DNA duplex unwinding GO:0032508 25 17 0,000 0,111417 0,15587537 GO:0032392|DNA geometric change, ! vacuolar transport GO:0007034 24 17 0,000 0,111417 0,15578061 ! cell-substrate junction assembly GO:0007044 39 17 0,000 0,111417 0,15568597 ! cellular macromolecular complex disassembly GO:0034623 29 17 0,000 0,111417 0,15559145 ! actin polymerization or depolymerization GO:0008154 31 17 0,000 0,111417 0,15549703 ! membrane budding GO:0006900 29 17 0,000 0,111417 0,15540274 ! heme metabolic process GO:0042168 27 17 0,000 0,111417 0,15530855 ! actin filament bundle formation GO:0051017 26 17 0,000 0,111417 0,15521448 ! negative regulation of protein catabolic process GO:0042177 26 17 0,000 0,111417 0,15512053 ! body fluid secretion GO:0007589 27 17 0,000 0,111417 0,15502669 ! stem cell differentiation GO:0048863 36 17 0,000 0,111417 0,15493296 ! ventricular cardiac muscle morphogenesis GO:0055010 23 17 0,000 0,111417 0,15483934 ! behavioral interaction between organisms GO:0051705 25 17 0,000 0,111417 0,15474584 ! sensory perception of pain GO:0019233 23 17 0,000 0,111417 0,15465245 ! regulation of immunoglobulin mediated immune response GO:0002889 25 17 0,000 0,111417 0,15455917 GO:0002712|regulation of B cell mediated immunity, ! long-chain fatty acid transport GO:0015909 24 17 0,000 0,111417 0,15446601 ! peptidyl-serine modification GO:0018209 27 17 0,000 0,111417 0,15437296 ! sphingolipid biosynthetic process GO:0030148 21 17 0,000 0,111417 0,15428002 GO:0046467|membrane lipid biosynthetic process, ! vitamin A metabolic process GO:0006776 22 17 0,000 0,111417 0,15418719 ! cell-cell junction organization GO:0045216 25 17 0,000 0,111417 0,15409447 ! regulation of immunoglobulin production GO:0002637 25 17 0,000 0,111417 0,15400187 ! aromatic compound catabolic process GO:0019439 22 17 0,000 0,111417 0,15390938 ! negative regulation of homeostatic process GO:0032845 28 17 0,000 0,111417 0,15381699 ! positive regulation of synaptic transmission GO:0050806 24 17 0,000 0,111417 0,15372472 ! negative regulation of coagulation GO:0050819 23 17 0,000 0,111417 0,15363256 ! regulation of cell adhesion GO:0030155 159 83 1,000 0,11275539 0,1553849 ! regulation of defense response GO:0031347 117 84 1,000 0,11500471 0,15838972 ! microtubule cytoskeleton organization GO:0000226 120 84 1,000 0,11500471 0,15829493 ! rRNA metabolic process GO:0016072 107 85 1,000 0,11726556 0,16131028 GO:0006364|rRNA processing, ! transcription initiation GO:0006352 118 85 1,000 0,11726556 0,16121386 ! regulation of protein localization GO:0032880 132 85 1,000 0,11726556 0,16111756 ! inhibition of adenylate cyclase activity by G-protein signaling GO:0007193 25 18 0,000 0,11757323 0,16144384 ! positive regulation of translation GO:0045727 28 18 0,000 0,11757323 0,16134752 ! positive regulation of anti-apoptosis GO:0045768 29 18 0,000 0,11757323 0,1612513 ! positive regulation of angiogenesis GO:0045766 35 18 0,000 0,11757323 0,16115521 ! post-Golgi vesicle-mediated transport GO:0006892 35 18 0,000 0,11757323 0,16105922 ! protein amino acid ADP-ribosylation GO:0006471 27 18 0,000 0,11757323 0,16096336 ! cAMP metabolic process GO:0046058 33 18 0,000 0,11757323 0,1608676 ! aminoglycan biosynthetic process GO:0006023 27 18 0,000 0,11757323 0,16077196 ! transcription from RNA polymerase III promoter GO:0006383 32 18 0,000 0,11757323 0,16067643 ! gamma-aminobutyric acid signaling pathway GO:0007214 20 18 0,000 0,11757323 0,16058102 ! axis specification GO:0009798 26 18 0,000 0,11757323 0,16048572 ! mechanoreceptor differentiation GO:0042490 32 18 0,000 0,11757323 0,16039053 ! pancreas development GO:0031016 26 18 0,000 0,11757323 0,16029546 ! response to carbohydrate stimulus GO:0009743 24 18 0,000 0,11757323 0,1602005 ! glutamine metabolic process GO:0006541 23 18 0,000 0,11757323 0,16010565 ! response to retinoic acid GO:0032526 25 18 0,000 0,11757323 0,16001091 ! pigmentation during development GO:0048066 31 18 0,000 0,11757323 0,15991629 ! central nervous system neuron development GO:0021954 30 18 0,000 0,11757323 0,15982177 ! positive regulation of cytoskeleton organization GO:0051495 33 18 0,000 0,11757323 0,15972737 ! fucose metabolic process GO:0006004 26 18 0,000 0,11757323 0,15963308 ! response to fungus GO:0009620 19 18 0,000 0,11757323 0,1595389 ! peptide cross-linking GO:0018149 31 18 0,000 0,11757323 0,15944483 ! positive regulation of alpha-beta T cell differentiation GO:0046638 25 18 0,000 0,11757323 0,15935088 ! heart process GO:0003015 27 18 0,000 0,11757323 0,15925703 GO:0060047|heart contraction, ! prostaglandin metabolic process GO:0006693 31 18 0,000 0,11757323 0,1591633 GO:0006692|prostanoid metabolic process, ! visual learning GO:0008542 35 18 0,000 0,11757323 0,15906967 ! synaptic vesicle transport GO:0048489 33 18 0,000 0,11757323 0,15897615 ! detection of chemical stimulus GO:0009593 26 18 0,000 0,11757323 0,15888275 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 25 18 0,000 0,11757323 0,15878945 ! cellular response to nutrient levels GO:0031669 27 18 0,000 0,11757323 0,15869627 ! regulation of cytokine secretion GO:0050707 26 18 0,000 0,11757323 0,15860319 ! vitamin transport GO:0051180 24 18 0,000 0,11757323 0,15851022 ! hormone transport GO:0009914 27 18 0,000 0,11757323 0,15841736 ! activation of JUN kinase activity GO:0007257 23 18 0,000 0,11757323 0,15832461 ! terpenoid metabolic process GO:0006721 24 18 0,000 0,11757323 0,15823197 ! positive regulation of transmission of nerve impulse GO:0051971 25 18 0,000 0,11757323 0,15813944 ! cell-cell recognition GO:0009988 20 18 0,000 0,11757323 0,15804701 ! purine nucleotide catabolic process GO:0006195 26 18 0,000 0,11757323 0,1579547 ! estrogen receptor signaling pathway GO:0030520 30 18 0,000 0,11757323 0,15786249 ! regulation of glucose import GO:0046324 21 18 0,000 0,11757323 0,15777038 GO:0010827|regulation of glucose transport, ! gut development GO:0048565 26 18 0,000 0,11757323 0,15767839 ! regulation of mitotic metaphase/anaphase transition GO:0030071 29 18 0,000 0,11757323 0,1575865 ! cellular monovalent inorganic cation homeostasis GO:0030004 28 18 0,000 0,11757323 0,15749472 ! interphase of mitotic cell cycle GO:0051329 156 86 1,000 0,11953768 0,16003298 ! Wnt receptor signaling pathway GO:0016055 130 87 1,000 0,1218208 0,16299467 ! protein import into nucleus, docking GO:0000059 30 19 0,000 0,12368716 0,16539562 ! pteridine and derivative metabolic process GO:0042558 23 19 0,000 0,12368716 0,16529952 ! reciprocal meiotic recombination GO:0007131 31 19 0,000 0,12368716 0,16520353 ! regulation of neuronal synaptic plasticity GO:0048168 36 19 0,000 0,12368716 0,16510765 ! regulation of postsynaptic membrane potential GO:0060078 30 19 0,000 0,12368716 0,16501188 ! C21-steroid hormone metabolic process GO:0008207 23 19 0,000 0,12368716 0,16491622 ! regeneration GO:0031099 32 19 0,000 0,12368716 0,16482067 ! sensory perception of taste GO:0050909 23 19 0,000 0,12368716 0,16472523 ! negative regulation of epithelial cell proliferation GO:0050680 34 19 0,000 0,12368716 0,1646299 ! smooth muscle contraction GO:0006939 36 19 0,000 0,12368716 0,16453469 ! peroxisome organization GO:0007031 29 19 0,000 0,12368716 0,16443958 ! digestive system process GO:0022600 30 19 0,000 0,12368716 0,16434458 ! polysaccharide catabolic process GO:0000272 23 19 0,000 0,12368716 0,1642497 ! response to vitamin A GO:0033189 26 19 0,000 0,12368716 0,16415492 ! D-ribose metabolic process GO:0006014 25 19 0,000 0,12368716 0,16406025 ! vesicle docking during exocytosis GO:0006904 24 19 0,000 0,12368716 0,16396569 ! response to starvation GO:0042594 30 19 0,000 0,12368716 0,16387124 ! response to lipopolysaccharide GO:0032496 26 19 0,000 0,12368716 0,1637769 ! plasma membrane fusion GO:0045026 23 19 0,000 0,12368716 0,16368267 ! cytolysis GO:0019835 20 19 0,000 0,12368716 0,16358854 ! vasodilation GO:0042311 33 19 0,000 0,12368716 0,16349452 ! regulation of interleukin-6 production GO:0032675 22 19 0,000 0,12368716 0,16340062 ! regulation of interleukin-2 production GO:0032663 31 19 0,000 0,12368716 0,16330682 ! negative regulation of angiogenesis GO:0016525 36 19 0,000 0,12368716 0,16321312 ! positive regulation of intracellular transport GO:0032388 29 19 0,000 0,12368716 0,16311954 ! positive regulation of neurological system process GO:0031646 28 19 0,000 0,12368716 0,16302606 ! sarcomere organization GO:0045214 23 19 0,000 0,12368716 0,16293269 ! positive regulation of myeloid cell differentiation GO:0045639 44 19 0,000 0,12368716 0,16283942 ! negative regulation of myeloid cell differentiation GO:0045638 26 19 0,000 0,12368716 0,16274627 ! aromatic amino acid family metabolic process GO:0009072 24 19 0,000 0,12368716 0,16265321 ! leukotriene biosynthetic process GO:0019370 26 19 0,000 0,12368716 0,16256027 GO:0043450|alkene biosynthetic process, ! embryonic organ morphogenesis GO:0048562 23 19 0,000 0,12368716 0,16246743 ! anatomical structure homeostasis GO:0060249 136 88 1,000 0,12411467 0,16293592 ! interphase GO:0051325 159 88 1,000 0,12411467 0,16284297 ! protein processing GO:0016485 114 88 1,000 0,12411467 0,16275013 ! regulation of T cell activation GO:0050863 128 89 1,000 0,12641903 0,16567736 ! protein modification by small protein conjugation GO:0032446 140 90 1,000 0,12873363 0,16861466 ! cellular aldehyde metabolic process GO:0006081 29 20 0,000 0,12975908 0,16986106 ! iron ion transport GO:0006826 37 20 0,000 0,12975908 0,16976444 ! protein amino acid O-linked glycosylation GO:0006493 29 20 0,000 0,12975908 0,16966792 ! glucosamine metabolic process GO:0006041 25 20 0,000 0,12975908 0,16957152 GO:0006044|N-acetylglucosamine metabolic process, ! microtubule-based transport GO:0010970 37 20 0,000 0,12975908 0,16947523 ! response to vitamin GO:0033273 29 20 0,000 0,12975908 0,16937905 ! regulation of receptor-mediated endocytosis GO:0048259 23 20 0,000 0,12975908 0,16928297 ! hindlimb morphogenesis GO:0035137 32 20 0,000 0,12975908 0,16918701 ! regulation of neurotransmitter transport GO:0051588 35 20 0,000 0,12975908 0,16909115 ! spinal cord development GO:0021510 31 20 0,000 0,12975908 0,1689954 ! response to ethanol GO:0045471 37 20 0,000 0,12975908 0,16889976 ! multicellular organismal response to stress GO:0033555 32 20 0,000 0,12975908 0,16880423 ! central nervous system neuron differentiation GO:0021953 33 20 0,000 0,12975908 0,16870881 ! neurotransmitter metabolic process GO:0042133 30 20 0,000 0,12975908 0,16861349 ! chromosome condensation GO:0030261 31 20 0,000 0,12975908 0,16851828 ! fatty acid beta-oxidation GO:0006635 31 20 0,000 0,12975908 0,16842318 ! regulation of myeloid leukocyte differentiation GO:0002761 34 20 0,000 0,12975908 0,16832819 ! determination of left/right symmetry GO:0007368 23 20 0,000 0,12975908 0,1682333 ! regulation of ARF GTPase activity GO:0032312 31 20 0,000 0,12975908 0,16813852 ! positive regulation of locomotion GO:0040017 35 20 0,000 0,12975908 0,16804385 GO:0048520|positive regulation of behavior, GO:0050921|positive regulation of chemotaxis, ! collagen fibril organization GO:0030199 45 20 0,000 0,12975908 0,16794928 ! neuromuscular process controlling balance GO:0050885 48 20 0,000 0,12975908 0,16785482 ! positive regulation of B cell activation GO:0050871 31 20 0,000 0,12975908 0,16776047 ! collagen catabolic process GO:0030574 25 20 0,000 0,12975908 0,16766622 ! regulation of leukocyte mediated cytotoxicity GO:0001910 32 20 0,000 0,12975908 0,16757208 ! camera-type eye morphogenesis GO:0048593 34 20 0,000 0,12975908 0,16747805 ! water-soluble vitamin biosynthetic process GO:0042364 22 20 0,000 0,12975908 0,16738412 ! alditol metabolic process GO:0019400 24 20 0,000 0,12975908 0,16729029 ! actin filament-based movement GO:0030048 34 20 0,000 0,12975908 0,16719657 ! cell fate commitment GO:0045165 141 92 1,000 0,13339256 0,17178214 ! DNA recombination GO:0006310 146 92 1,000 0,13339256 0,17168601 ! sulfur metabolic process GO:0006790 118 92 1,000 0,13339256 0,17158999 ! G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 130 92 1,000 0,13339256 0,17149407 ! carbohydrate catabolic process GO:0016052 121 93 1,000 0,1357364 0,17440991 ! regulation of cell killing GO:0031341 34 21 0,000 0,13578927 0,17438041 ! G2/M transition of mitotic cell cycle GO:0000086 33 21 0,000 0,13578927 0,1742831 ! sulfur amino acid metabolic process GO:0000096 24 21 0,000 0,13578927 0,1741859 ! determination of bilateral symmetry GO:0009855 25 21 0,000 0,13578927 0,1740888 GO:0009799|determination of symmetry, ! gluconeogenesis GO:0006094 25 21 0,000 0,13578927 0,17399182 ! nucleotide-excision repair, DNA damage removal GO:0000718 26 21 0,000 0,13578927 0,17389494 ! cellular polysaccharide biosynthetic process GO:0033692 26 21 0,000 0,13578927 0,17379817 ! regulation of chemotaxis GO:0050920 36 21 0,000 0,13578927 0,17370151 ! vesicle docking GO:0048278 27 21 0,000 0,13578927 0,17360495 ! phototransduction GO:0007602 25 21 0,000 0,13578927 0,17350851 ! visual behavior GO:0007632 39 21 0,000 0,13578927 0,17341217 ! deoxyribonucleotide metabolic process GO:0009262 27 21 0,000 0,13578927 0,17331593 ! purine ribonucleoside metabolic process GO:0046128 28 21 0,000 0,13578927 0,17321981 GO:0042278|purine nucleoside metabolic process, ! autophagy GO:0006914 28 21 0,000 0,13578927 0,17312379 ! regulation of specific transcription from RNA polymerase II promoter GO:0010551 33 21 0,000 0,13578927 0,17302787 ! response to endoplasmic reticulum stress GO:0034976 25 21 0,000 0,13578927 0,17293207 ! regulation of insulin secretion GO:0050796 26 21 0,000 0,13578927 0,17283636 ! regulation of alpha-beta T cell differentiation GO:0046637 30 21 0,000 0,13578927 0,17274077 ! positive regulation of alpha-beta T cell activation GO:0046635 30 21 0,000 0,13578927 0,17264528 ! cardiac muscle tissue morphogenesis GO:0055008 27 21 0,000 0,13578927 0,1725499 GO:0060415|muscle tissue morphogenesis, ! leukotriene metabolic process GO:0006691 28 21 0,000 0,13578927 0,17245462 ! glycosphingolipid metabolic process GO:0006687 33 21 0,000 0,13578927 0,17235944 ! fatty acid transport GO:0015908 30 21 0,000 0,13578927 0,17226437 ! platelet activation GO:0030168 28 21 0,000 0,13578927 0,17216941 ! negative regulation of Wnt receptor signaling pathway GO:0030178 31 21 0,000 0,13578927 0,17207455 ! positive regulation of protein secretion GO:0050714 26 21 0,000 0,13578927 0,1719798 ! positive regulation of adaptive immune response GO:0002821 31 21 0,000 0,13578927 0,17188515 ! cellular response to extracellular stimulus GO:0031668 32 21 0,000 0,13578927 0,1717906 ! response to glucocorticoid stimulus GO:0051384 33 21 0,000 0,13578927 0,17169616 ! nerve-nerve synaptic transmission GO:0007270 36 21 0,000 0,13578927 0,17160182 ! response to cytokine stimulus GO:0034097 47 21 0,000 0,13578927 0,17150758 ! glutamine family amino acid catabolic process GO:0009065 30 21 0,000 0,13578927 0,17141345 ! porphyrin metabolic process GO:0006778 35 21 0,000 0,13578927 0,17131942 GO:0033013|tetrapyrrole metabolic process, ! negative regulation of cytokine production GO:0001818 31 21 0,000 0,13578927 0,1712255 ! regulation of multi-organism process GO:0043900 32 21 0,000 0,13578927 0,17113168 ! electron transport chain GO:0022900 123 94 1,000 0,13808951 0,17393531 ! response to oxidative stress GO:0006979 141 94 1,000 0,13808951 0,1738401 ! protein import into nucleus, translocation GO:0000060 36 22 0,000 0,14177801 0,1783859 ! regulation of anti-apoptosis GO:0045767 36 22 0,000 0,14177801 0,17828837 ! viral genome replication GO:0019079 29 22 0,000 0,14177801 0,17819094 ! regulation of transmembrane transport GO:0034762 30 22 0,000 0,14177801 0,17809363 ! spliceosomal snRNP biogenesis GO:0000387 28 22 0,000 0,14177801 0,17799641 ! leukocyte adhesion GO:0007159 38 22 0,000 0,14177801 0,17789931 ! molting cycle process GO:0022404 40 22 0,000 0,14177801 0,17780231 GO:0022405|hair cycle process, GO:0001942|hair follicle development, GO:0042633|hair cycle, GO:0042303|molting cycle, ! glutamate signaling pathway GO:0007215 34 22 0,000 0,14177801 0,17770541 ! macromolecular complex disassembly GO:0032984 38 22 0,000 0,14177801 0,17760862 ! vasculogenesis GO:0001570 33 22 0,000 0,14177801 0,17751194 ! microtubule organizing center organization GO:0031023 28 22 0,000 0,14177801 0,17741536 GO:0051297|centrosome organization, ! regulation of cell-matrix adhesion GO:0001952 51 22 0,000 0,14177801 0,17731888 GO:0010810|regulation of cell-substrate adhesion, ! DNA damage response, signal transduction by p53 class mediator GO:0030330 47 22 0,000 0,14177801 0,17722251 ! immune response-activating cell surface receptor signaling pathway GO:0002429 32 22 0,000 0,14177801 0,17712625 GO:0002768|immune response-regulating cell surface receptor signaling pathway, ! regulation of smooth muscle contraction GO:0006940 36 22 0,000 0,14177801 0,17703009 ! lysosome organization GO:0007040 37 22 0,000 0,14177801 0,17693404 ! barbed-end actin filament capping GO:0051016 33 22 0,000 0,14177801 0,17683808 GO:0051693|actin filament capping, ! regulation of behavior GO:0050795 38 22 0,000 0,14177801 0,17674224 ! vitamin biosynthetic process GO:0009110 24 22 0,000 0,14177801 0,17664649 ! regulation of tumor necrosis factor production GO:0032680 28 22 0,000 0,14177801 0,17655085 ! membrane depolarization GO:0051899 35 22 0,000 0,14177801 0,17645532 ! proteoglycan biosynthetic process GO:0030166 32 22 0,000 0,14177801 0,17635989 ! leukocyte homeostasis GO:0001776 33 22 0,000 0,14177801 0,17626456 ! regulation of blood coagulation GO:0030193 34 22 0,000 0,14177801 0,17616933 ! cellular alkene metabolic process GO:0043449 29 22 0,000 0,14177801 0,1760742 ! aspartate family amino acid metabolic process GO:0009066 24 22 0,000 0,14177801 0,17597918 ! blastocyst development GO:0001824 37 22 0,000 0,14177801 0,17588427 ! neural tube closure GO:0001843 33 22 0,000 0,14177801 0,17578945 GO:0060606|tube closure, GO:0035148|tube lumen formation, ! positive regulation of JUN kinase activity GO:0043507 28 22 0,000 0,14177801 0,17569473 ! regulation of response to external stimulus GO:0032101 139 96 1,000 0,14282256 0,17689385 ! protein modification by small protein conjugation or removal GO:0070647 148 96 1,000 0,14282256 0,17679865 ! response to light stimulus GO:0009416 153 96 1,000 0,14282256 0,17670354 ! neuron fate commitment GO:0048663 32 23 0,000 0,1477256 0,18267144 ! embryonic pattern specification GO:0009880 31 23 0,000 0,1477256 0,18257328 ! regulation of transcription factor import into nucleus GO:0042990 46 23 0,000 0,1477256 0,18247523 ! ER-nuclear signaling pathway GO:0006984 27 23 0,000 0,1477256 0,18237728 ! negative regulation of DNA replication GO:0008156 35 23 0,000 0,1477256 0,18227944 ! vesicle targeting GO:0006903 32 23 0,000 0,1477256 0,1821817 ! response to corticosteroid stimulus GO:0031960 36 23 0,000 0,1477256 0,18208407 ! osteoblast differentiation GO:0001649 40 23 0,000 0,1477256 0,18198654 ! regulation of viral reproduction GO:0050792 32 23 0,000 0,1477256 0,18188912 ! hydrogen peroxide metabolic process GO:0042743 30 23 0,000 0,1477256 0,1817918 ! lymphocyte proliferation GO:0046651 36 23 0,000 0,1477256 0,18169459 ! negative regulation of phosphorylation GO:0042326 41 23 0,000 0,1477256 0,18159748 ! glycolipid metabolic process GO:0006664 36 23 0,000 0,1477256 0,18150047 ! cell fate determination GO:0001709 45 23 0,000 0,1477256 0,18140356 ! pentose metabolic process GO:0019321 31 23 0,000 0,1477256 0,18130676 ! regulation of response to biotic stimulus GO:0002831 35 23 0,000 0,1477256 0,18121007 ! spermatid development GO:0007286 33 23 0,000 0,1477256 0,18111347 ! group transfer coenzyme metabolic process GO:0006752 28 23 0,000 0,1477256 0,18101698 ! fat-soluble vitamin metabolic process GO:0006775 28 23 0,000 0,1477256 0,18092059 ! ethanolamine and derivative metabolic process GO:0042439 33 23 0,000 0,1477256 0,18082431 ! telomere organization GO:0032200 32 23 0,000 0,1477256 0,18072813 GO:0000723|telomere maintenance, ! negative regulation of catabolic process GO:0009895 34 23 0,000 0,1477256 0,18063204 ! response to molecule of bacterial origin GO:0002237 30 23 0,000 0,1477256 0,18053607 ! regulation of amine transport GO:0051952 38 23 0,000 0,1477256 0,18044019 ! liver development GO:0001889 40 23 0,000 0,1477256 0,18034441 ! cyclic-nucleotide-mediated signaling GO:0019935 146 100 1,000 0,15238954 0,18593949 ! regulation of body fluid levels GO:0050878 154 100 1,000 0,15238954 0,1858409 ! initiation of viral infection GO:0019059 42 24 0,000 0,15363231 0,18725718 ! regulation of interferon-gamma production GO:0032649 30 24 0,000 0,15363231 0,187158 ! pyruvate metabolic process GO:0006090 29 24 0,000 0,15363231 0,18705892 ! superoxide metabolic process GO:0006801 32 24 0,000 0,15363231 0,18695995 ! detection of light stimulus involved in sensory perception GO:0050962 28 24 0,000 0,15363231 0,18686108 GO:0050908|detection of light stimulus involved in visual perception, GO:0009584|detection of visible light, ! regulation of endothelial cell proliferation GO:0001936 46 24 0,000 0,15363231 0,18676232 ! fat cell differentiation GO:0045444 37 24 0,000 0,15363231 0,18666366 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 32 24 0,000 0,15363231 0,1865651 ! sperm motility GO:0030317 27 24 0,000 0,15363231 0,18646665 ! mitochondrial membrane organization GO:0007006 39 24 0,000 0,15363231 0,1863683 ! vacuole organization GO:0007033 39 24 0,000 0,15363231 0,18627006 ! receptor metabolic process GO:0043112 37 24 0,000 0,15363231 0,18617192 ! neural crest cell development GO:0014032 39 24 0,000 0,15363231 0,18607388 GO:0014033|neural crest cell differentiation, ! response to toxin GO:0009636 38 24 0,000 0,15363231 0,18597595 ! primary neural tube formation GO:0014020 35 24 0,000 0,15363231 0,18587812 ! negative regulation of cell development GO:0010721 56 24 0,000 0,15363231 0,18578039 GO:0050768|negative regulation of neurogenesis, ! regulation of alpha-beta T cell activation GO:0046634 35 24 0,000 0,15363231 0,18568277 ! base-excision repair GO:0006284 31 24 0,000 0,15363231 0,18558524 ! positive regulation of leukocyte mediated immunity GO:0002705 33 24 0,000 0,15363231 0,18548782 GO:0002708|positive regulation of lymphocyte mediated immunity, ! fibroblast growth factor receptor signaling pathway GO:0008543 39 24 0,000 0,15363231 0,18539051 ! glutathione metabolic process GO:0006749 29 24 0,000 0,15363231 0,18529329 ! neurotransmitter secretion GO:0007269 32 24 0,000 0,15363231 0,18519618 ! regulation of JUN kinase activity GO:0043506 34 24 0,000 0,15363231 0,18509916 ! negative regulation of actin filament depolymerization GO:0030835 36 25 0,000 0,15949841 0,19206615 ! negative regulation of actin filament polymerization GO:0030837 36 25 0,000 0,15949841 0,19196565 ! amino sugar metabolic process GO:0006040 31 25 0,000 0,15949841 0,19186525 ! protein amino acid alkylation GO:0008213 39 25 0,000 0,15949841 0,19176495 GO:0006479|protein amino acid methylation, ! calcium-dependent cell-cell adhesion GO:0016339 30 25 0,000 0,15949841 0,19166476 ! cellular carbohydrate biosynthetic process GO:0034637 30 25 0,000 0,15949841 0,19156467 ! peptide transport GO:0015833 43 25 0,000 0,15949841 0,19146469 ! male gonad development GO:0008584 33 25 0,000 0,15949841 0,19136481 ! regulation of peptide secretion GO:0002791 34 25 0,000 0,15949841 0,19126504 ! cyclic nucleotide biosynthetic process GO:0009190 36 25 0,000 0,15949841 0,19116537 ! phospholipid transport GO:0015914 35 25 0,000 0,15949841 0,19106581 ! response to estradiol stimulus GO:0032355 34 25 0,000 0,15949841 0,19096634 ! positive regulation of MAPKKK cascade GO:0043410 36 25 0,000 0,15949841 0,19086699 ! detection of light stimulus GO:0009583 30 25 0,000 0,15949841 0,19076773 ! positive regulation of nuclear division GO:0051785 39 25 0,000 0,15949841 0,19066858 GO:0045840|positive regulation of mitosis, ! leukocyte proliferation GO:0070661 39 25 0,000 0,15949841 0,19056953 GO:0032943|mononuclear cell proliferation, ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 29 26 0,000 0,1653242 0,19742765 ! positive regulation of smooth muscle cell proliferation GO:0048661 40 26 0,000 0,1653242 0,19732519 ! translational initiation GO:0006413 43 26 0,000 0,1653242 0,19722285 ! regulation of pH GO:0006885 36 26 0,000 0,1653242 0,19712061 ! circadian rhythm GO:0007623 42 26 0,000 0,1653242 0,19701847 ! post-embryonic development GO:0009791 42 26 0,000 0,1653242 0,19691644 ! positive regulation of innate immune response GO:0045089 31 26 0,000 0,1653242 0,19681452 ! multicellular organismal catabolic process GO:0044243 32 26 0,000 0,1653242 0,1967127 ! negative regulation of protein kinase cascade GO:0010741 51 26 0,000 0,1653242 0,19661099 ! nicotinamide metabolic process GO:0006769 39 26 0,000 0,1653242 0,19650938 GO:0046496|nicotinamide nucleotide metabolic process, ! spermatid differentiation GO:0048515 36 26 0,000 0,1653242 0,19640788 ! negative regulation of protein polymerization GO:0032272 38 26 0,000 0,1653242 0,19630648 ! regulation of coagulation GO:0050818 39 26 0,000 0,1653242 0,19620519 ! alkaloid metabolic process GO:0009820 40 27 0,000 0,17110993 0,20296691 ! regulation of actin filament depolymerization GO:0030834 39 27 0,000 0,17110993 0,20286229 ! activation of adenylate cyclase activity by G-protein signaling pathway GO:0007189 45 27 0,000 0,17110993 0,20275777 GO:0010579|positive regulation of adenylate cyclase activity by G-protein signaling pathway, GO:0010578|regulation of adenylate cyclase activity involved in G-protein signaling, ! proteoglycan metabolic process GO:0006029 41 27 0,000 0,17110993 0,20265337 ! membrane docking GO:0022406 39 27 0,000 0,17110993 0,20254907 ! inner ear morphogenesis GO:0042472 35 27 0,000 0,17110993 0,20244488 ! catechol metabolic process GO:0009712 43 27 0,000 0,17110993 0,20234079 GO:0006584|catecholamine metabolic process, GO:0034311|diol metabolic process, ! GPI anchor biosynthetic process GO:0006506 37 27 0,000 0,17110993 0,20223681 ! acute-phase response GO:0006953 42 27 0,000 0,17110993 0,20213294 ! myofibril assembly GO:0030239 36 27 0,000 0,17110993 0,20202918 GO:0055002|striated muscle cell development, ! respiratory gaseous exchange GO:0007585 47 27 0,000 0,17110993 0,20192552 ! response to ionizing radiation GO:0010212 47 27 0,000 0,17110993 0,20182197 ! regulation of production of molecular mediator of immune response GO:0002700 40 27 0,000 0,17110993 0,20171852 ! natural killer cell activation GO:0030101 35 27 0,000 0,17110993 0,20161518 ! lipid oxidation GO:0034440 38 27 0,000 0,17110993 0,20151195 GO:0019395|fatty acid oxidation, ! serine family amino acid metabolic process GO:0009069 37 27 0,000 0,17110993 0,20140882 ! negative regulation of transcription regulator activity GO:0090048 47 27 0,000 0,17110993 0,2013058 GO:0043433|negative regulation of transcription factor activity, ! negative regulation of neuron apoptosis GO:0043524 42 27 0,000 0,17110993 0,20120288 ! gene silencing GO:0016458 41 27 0,000 0,17110993 0,20110007 ! mRNA export from nucleus GO:0006406 39 28 0,000 0,17685589 0,20774696 ! phenol metabolic process GO:0018958 44 28 0,000 0,17685589 0,20764091 ! icosanoid biosynthetic process GO:0046456 42 28 0,000 0,17685589 0,20753497 ! negative regulation of response to external stimulus GO:0032102 37 28 0,000 0,17685589 0,20742914 ! cell junction assembly GO:0034329 56 28 0,000 0,17685589 0,20732342 ! cholesterol homeostasis GO:0042632 46 28 0,000 0,17685589 0,2072178 GO:0055092|sterol homeostasis, ! GPI anchor metabolic process GO:0006505 40 28 0,000 0,17685589 0,20711229 ! complement activation, classical pathway GO:0006958 36 28 0,000 0,17685589 0,20700689 ! triglyceride metabolic process GO:0006641 34 28 0,000 0,17685589 0,2069016 ! erythrocyte differentiation GO:0030218 38 28 0,000 0,17685589 0,20679641 ! immune response-activating signal transduction GO:0002757 38 28 0,000 0,17685589 0,20669133 GO:0002764|immune response-regulating signal transduction, ! response to organic cyclic substance GO:0014070 47 28 0,000 0,17685589 0,20658636 ! positive regulation of T cell differentiation GO:0045582 39 28 0,000 0,17685589 0,20648149 ! nuclear-transcribed mRNA catabolic process GO:0000956 38 28 0,000 0,17685589 0,20637673 ! mesoderm formation GO:0001707 46 28 0,000 0,17685589 0,20627208 ! pyridine nucleotide metabolic process GO:0019362 41 28 0,000 0,17685589 0,20616753 ! myeloid leukocyte activation GO:0002274 39 28 0,000 0,17685589 0,20606309 ! neural tube formation GO:0001841 41 28 0,000 0,17685589 0,20595876 ! placenta development GO:0001890 37 28 0,000 0,17685589 0,20585452 ! regulation of B cell activation GO:0050864 42 28 0,000 0,17685589 0,2057504 ! response to hydrogen peroxide GO:0042542 42 29 0,000 0,18256234 0,21228179 ! regulation of innate immune response GO:0045088 38 29 0,000 0,18256234 0,21217452 ! positive regulation of T cell proliferation GO:0042102 44 29 0,000 0,18256234 0,21206737 ! protein targeting to membrane GO:0006612 53 29 0,000 0,18256234 0,21196031 ! regulation of axonogenesis GO:0050770 51 29 0,000 0,18256234 0,21185337 ! regulation of protein import into nucleus GO:0042306 53 29 0,000 0,18256234 0,21174654 ! muscle cell development GO:0055001 38 29 0,000 0,18256234 0,21163981 ! formation of primary germ layer GO:0001704 48 29 0,000 0,18256234 0,21153319 ! hexose biosynthetic process GO:0019319 35 29 0,000 0,18256234 0,21142668 ! eye morphogenesis GO:0048592 51 29 0,000 0,18256234 0,21132027 ! regulation of calcium ion transport GO:0051924 37 29 0,000 0,18256234 0,21121398 ! collagen metabolic process GO:0032963 40 30 0,000 0,18822956 0,21766113 ! organic anion transport GO:0015711 51 30 0,000 0,18822956 0,21755175 ! cholesterol transport GO:0030301 46 30 0,000 0,18822956 0,21744248 GO:0015918|sterol transport, ! spliceosome assembly GO:0000245 49 30 0,000 0,18822956 0,21733333 ! spindle organization GO:0007051 37 30 0,000 0,18822956 0,21722428 ! pigment biosynthetic process GO:0046148 50 30 0,000 0,18822956 0,21711534 ! humoral immune response mediated by circulating immunoglobulin GO:0002455 39 30 0,000 0,18822956 0,21700651 ! ceramide metabolic process GO:0006672 43 30 0,000 0,18822956 0,21689779 ! fatty acid catabolic process GO:0009062 43 30 0,000 0,18822956 0,21678918 ! adult locomotory behavior GO:0008344 47 30 0,000 0,18822956 0,21668067 ! embryonic epithelial tube formation GO:0001838 44 30 0,000 0,18822956 0,21657228 ! response to heat GO:0009408 41 30 0,000 0,18822956 0,21646399 ! positive regulation of immune effector process GO:0002699 40 30 0,000 0,18822956 0,21635581 ! establishment of vesicle localization GO:0051650 45 30 0,000 0,18822956 0,21624775 ! DNA damage checkpoint GO:0000077 53 31 0,000 0,19385781 0,22260258 ! negative regulation of secretion GO:0051048 49 31 0,000 0,19385781 0,2224915 ! glial cell differentiation GO:0010001 55 31 0,000 0,19385781 0,22238053 ! cellular component assembly involved in morphogenesis GO:0010927 43 31 0,000 0,19385781 0,22226967 ! xenobiotic metabolic process GO:0006805 44 31 0,000 0,19385781 0,22215892 ! maintenance of protein location in cell GO:0032507 60 31 0,000 0,19385781 0,22204829 ! regulation of striated muscle tissue development GO:0016202 47 31 0,000 0,19385781 0,22193776 ! mesoderm morphogenesis GO:0048332 49 31 0,000 0,19385781 0,22182734 ! positive regulation of gene-specific transcription GO:0043193 47 31 0,000 0,19385781 0,22171704 ! unsaturated fatty acid biosynthetic process GO:0006636 46 31 0,000 0,19385781 0,22160684 ! cell fate specification GO:0001708 37 31 0,000 0,19385781 0,22149675 ! leukocyte chemotaxis GO:0030595 43 31 0,000 0,19385781 0,22138677 GO:0060326|cell chemotaxis, ! biogenic amine biosynthetic process GO:0042401 44 31 0,000 0,19385781 0,2212769 ! RNA modification GO:0009451 40 31 0,000 0,19385781 0,22116714 ! regulation of muscle development GO:0048634 48 32 0,000 0,19944736 0,22743129 ! mitotic sister chromatid segregation GO:0000070 45 32 0,000 0,19944736 0,22731859 ! regulation of synaptic plasticity GO:0048167 52 32 0,000 0,19944736 0,227206 ! regulation of ARF protein signal transduction GO:0032012 51 32 0,000 0,19944736 0,22709353 ! neutral lipid metabolic process GO:0006638 41 32 0,000 0,19944736 0,22698116 GO:0006639|acylglycerol metabolic process, ! monovalent inorganic cation homeostasis GO:0055067 45 32 0,000 0,19944736 0,2268689 ! calcium-mediated signaling GO:0019722 50 32 0,000 0,19944736 0,22675676 ! positive regulation of lymphocyte differentiation GO:0045621 45 32 0,000 0,19944736 0,22664472 ! cytokine production GO:0001816 44 32 0,000 0,19944736 0,2265328 ! monosaccharide biosynthetic process GO:0046364 38 32 0,000 0,19944736 0,22642099 ! vesicle localization GO:0051648 47 32 0,000 0,19944736 0,22630929 ! negative regulation of adenylate cyclase activity GO:0007194 48 33 0,000 0,20499847 0,23249333 GO:0051350|negative regulation of lyase activity, GO:0031280|negative regulation of cyclase activity, ! RNA export from nucleus GO:0006405 44 33 0,000 0,20499847 0,23237875 ! phosphoinositide biosynthetic process GO:0046489 47 33 0,000 0,20499847 0,23226427 ! ER to Golgi vesicle-mediated transport GO:0006888 53 33 0,000 0,20499847 0,23214991 ! negative regulation of cell adhesion GO:0007162 67 33 0,000 0,20499847 0,23203567 ! sister chromatid segregation GO:0000819 46 33 0,000 0,20499847 0,23192153 ! actomyosin structure organization GO:0031032 43 33 0,000 0,20499847 0,23180751 ! cell junction organization GO:0034330 63 33 0,000 0,20499847 0,2316936 ! sphingoid metabolic process GO:0046519 47 33 0,000 0,20499847 0,2315798 ! multicellular organismal macromolecule metabolic process GO:0044259 44 33 0,000 0,20499847 0,23146611 ! negative regulation of DNA binding GO:0043392 54 33 0,000 0,20499847 0,23135254 ! lipid homeostasis GO:0055088 55 33 0,000 0,20499847 0,23123908 ! nucleotide catabolic process GO:0009166 46 33 0,000 0,20499847 0,23112572 ! regulation of proteolysis GO:0030162 50 33 0,000 0,20499847 0,23101248 ! hormone biosynthetic process GO:0042446 45 33 0,000 0,20499847 0,23089935 ! cytokinesis GO:0000910 52 33 0,000 0,20499847 0,23078633 ! mRNA catabolic process GO:0006402 48 34 0,000 0,2105114 0,23687682 ! regulation of neuron projection development GO:0010975 63 34 0,000 0,2105114 0,23676099 ! feeding behavior GO:0007631 45 34 0,000 0,2105114 0,23664527 ! mitotic cell cycle checkpoint GO:0007093 63 34 0,000 0,2105114 0,23652966 ! development of primary male sexual characteristics GO:0046546 44 34 0,000 0,2105114 0,23641417 ! DNA integrity checkpoint GO:0031570 57 34 0,000 0,2105114 0,23629879 ! glycerol ether metabolic process GO:0006662 44 34 0,000 0,2105114 0,23618352 ! erythrocyte homeostasis GO:0034101 45 34 0,000 0,2105114 0,23606837 ! regulation of Wnt receptor signaling pathway GO:0030111 52 34 0,000 0,2105114 0,23595333 ! isoprenoid metabolic process GO:0006720 46 34 0,000 0,2105114 0,23583839 ! polyol metabolic process GO:0019751 44 34 0,000 0,2105114 0,23572358 ! embryonic organ development GO:0048568 45 34 0,000 0,2105114 0,23560887 ! regulation of cell morphogenesis involved in differentiation GO:0010769 62 34 0,000 0,2105114 0,23549427 ! regulation of metal ion transport GO:0010959 47 35 0,000 0,21598642 0,24150159 ! Notch signaling pathway GO:0007219 56 35 0,000 0,21598642 0,24138424 ! polysaccharide biosynthetic process GO:0000271 47 35 0,000 0,21598642 0,24126701 ! regulation of Rab protein signal transduction GO:0032483 52 35 0,000 0,21598642 0,24114989 GO:0032313|regulation of Rab GTPase activity, ! cyclic nucleotide metabolic process GO:0009187 58 35 0,000 0,21598642 0,24103288 ! energy coupled proton transport, down electrochemical gradient GO:0015985 53 35 0,000 0,21598642 0,24091599 GO:0015986|ATP synthesis coupled proton transport, ! maintenance of protein location GO:0045185 65 35 0,000 0,21598642 0,24079921 ! Rho protein signal transduction GO:0007266 51 35 0,000 0,21598642 0,24068254 ! glycogen metabolic process GO:0005977 48 35 0,000 0,21598642 0,24056599 ! pigment metabolic process GO:0042440 61 35 0,000 0,21598642 0,24044955 ! positive regulation of leukocyte proliferation GO:0070665 50 35 0,000 0,21598642 0,24033322 GO:0070668|positive regulation of mast cell proliferation, GO:0050671|positive regulation of lymphocyte proliferation, GO:0032946|positive regulation of mononuclear cell proliferation, ! protein homooligomerization GO:0051260 52 35 0,000 0,21598642 0,240217 ! regulation of hormone secretion GO:0046883 48 36 0,000 0,22142378 0,24614533 ! negative regulation of binding GO:0051100 58 36 0,000 0,22142378 0,24602642 ! organic ether metabolic process GO:0018904 46 36 0,000 0,22142378 0,24590763 ! hormone-mediated signaling GO:0009755 49 36 0,000 0,22142378 0,24578895 ! heterocycle biosynthetic process GO:0018130 46 36 0,000 0,22142378 0,24567038 ! response to xenobiotic stimulus GO:0009410 50 36 0,000 0,22142378 0,24555193 ! glucan metabolic process GO:0044042 49 36 0,000 0,22142378 0,24543359 GO:0006073|cellular glucan metabolic process, ! activation of plasma proteins involved in acute inflammatory response GO:0002541 45 37 0,000 0,22682374 0,25129798 GO:0006956|complement activation, ! protein amino acid N-linked glycosylation GO:0006487 49 37 0,000 0,22682374 0,25117699 ! learning GO:0007612 67 37 0,000 0,22682374 0,25105612 ! ion transmembrane transport GO:0034220 56 37 0,000 0,22682374 0,25093536 ! regulation of protein secretion GO:0050708 51 37 0,000 0,22682374 0,25081471 ! amino acid activation GO:0043038 52 37 0,000 0,22682374 0,25069419 GO:0043039|tRNA aminoacylation, GO:0006418|tRNA aminoacylation for protein translation, ! oxidoreduction coenzyme metabolic process GO:0006733 52 37 0,000 0,22682374 0,25057378 ! transforming growth factor beta receptor signaling pathway GO:0007179 51 38 0,000 0,23218656 0,25637498 ! gliogenesis GO:0042063 71 38 0,000 0,23218656 0,25625196 ! striated muscle cell differentiation GO:0051146 54 38 0,000 0,23218656 0,25612906 ! monocarboxylic acid transport GO:0015718 62 38 0,000 0,23218656 0,25600627 ! alcohol biosynthetic process GO:0046165 45 38 0,000 0,23218656 0,25588361 ! phagocytosis GO:0006909 60 38 0,000 0,23218656 0,25576106 ! maintenance of location in cell GO:0051651 69 38 0,000 0,23218656 0,25563862 ! morphogenesis of embryonic epithelium GO:0016331 60 39 0,000 0,23751248 0,26137737 ! male sex differentiation GO:0046661 53 39 0,000 0,23751248 0,26125237 ! regulation of lymphocyte mediated immunity GO:0002706 60 39 0,000 0,23751248 0,26112749 ! I-kappaB kinase/NF-kappaB cascade GO:0007249 49 39 0,000 0,23751248 0,26100273 ! cell growth GO:0016049 61 39 0,000 0,23751248 0,26087809 ! regulation of actin filament polymerization GO:0030833 59 40 0,000 0,24280177 0,26656041 ! response to calcium ion GO:0051592 58 40 0,000 0,24280177 0,26643324 ! cytoskeleton-dependent intracellular transport GO:0030705 71 40 0,000 0,24280177 0,26630618 ! peptide metabolic process GO:0006518 56 40 0,000 0,24280177 0,26617925 ! inner ear development GO:0048839 57 40 0,000 0,24280177 0,26605244 ! double-strand break repair GO:0006302 67 40 0,000 0,24280177 0,26592575 ! B cell differentiation GO:0030183 62 40 0,000 0,24280177 0,26579917 ! regulation of myeloid cell differentiation GO:0045637 69 40 0,000 0,24280177 0,26567272 ! positive regulation of protein transport GO:0051222 55 40 0,000 0,24280177 0,26554639 ! epithelial cell differentiation GO:0030855 55 41 0,000 0,24805466 0,27116242 ! protein amino acid lipidation GO:0006497 62 41 0,000 0,24805466 0,2710336 ! energy reserve metabolic process GO:0006112 59 41 0,000 0,24805466 0,2709049 ! glucose transport GO:0015758 52 41 0,000 0,24805466 0,27077633 ! endosome transport GO:0016197 71 41 0,000 0,24805466 0,27064788 ! striated muscle contraction GO:0006941 62 41 0,000 0,24805466 0,27051955 ! regulation of leukocyte mediated immunity GO:0002703 62 41 0,000 0,24805466 0,27039134 ! regulation of JNK cascade GO:0046328 58 41 0,000 0,24805466 0,27026325 ! mitochondrial transport GO:0006839 60 42 0,000 0,25327141 0,27581641 ! receptor-mediated endocytosis GO:0006898 76 42 0,000 0,25327141 0,27568587 ! regulation of stress-activated protein kinase signaling pathway GO:0070302 61 42 0,000 0,25327141 0,27555547 ! hexose transport GO:0008645 54 42 0,000 0,25327141 0,27542518 GO:0015749|monosaccharide transport, ! positive regulation of cytokine biosynthetic process GO:0042108 54 42 0,000 0,25327141 0,27529502 ! excretion GO:0007588 63 42 0,000 0,25327141 0,27516498 ! glycosaminoglycan metabolic process GO:0030203 63 42 0,000 0,25327141 0,27503506 ! icosanoid metabolic process GO:0006690 61 42 0,000 0,25327141 0,27490526 ! leukocyte migration GO:0050900 60 43 0,000 0,25845227 0,28039633 ! DNA-dependent DNA replication GO:0006261 59 43 0,000 0,25845227 0,28026413 ! tRNA processing GO:0008033 49 43 0,000 0,25845227 0,28013206 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 66 43 0,000 0,25845227 0,28000011 ! vesicle organization GO:0016050 79 43 0,000 0,25845227 0,27986828 ! activation of adenylate cyclase activity GO:0007190 76 44 0,000 0,26359748 0,28530551 ! regulation of ion transport GO:0043269 57 44 0,000 0,26359748 0,28517131 ! cellular amino acid biosynthetic process GO:0008652 51 44 0,000 0,26359748 0,28503724 ! generation of a signal involved in cell-cell signaling GO:0003001 62 44 0,000 0,26359748 0,28490329 ! ribonucleoprotein complex assembly GO:0022618 70 44 0,000 0,26359748 0,28476947 ! RNA catabolic process GO:0006401 64 45 0,000 0,26870728 0,2901534 ! lipoprotein biosynthetic process GO:0042158 67 45 0,000 0,26870728 0,29001724 ! cell recognition GO:0008037 58 45 0,000 0,26870728 0,28988121 ! cell maturation GO:0048469 60 45 0,000 0,26870728 0,28974531 ! positive regulation of adenylate cyclase activity GO:0045762 86 46 0,000 0,27378192 0,29507892 ! cell redox homeostasis GO:0045454 63 46 0,000 0,27378192 0,29494071 ! unsaturated fatty acid metabolic process GO:0033559 66 46 0,000 0,27378192 0,29480263 ! regulation of adaptive immune response GO:0002819 72 46 0,000 0,27378192 0,29466467 ! viral infectious cycle GO:0019058 71 47 0,000 0,27882163 0,29994843 ! response to estrogen stimulus GO:0043627 74 47 0,000 0,27882163 0,2998082 ! endocrine system development GO:0035270 83 47 0,000 0,27882163 0,2996681 ! RNA elongation from RNA polymerase II promoter GO:0006368 60 47 0,000 0,27882163 0,29952814 ! positive regulation of cyclase activity GO:0031281 87 47 0,000 0,27882163 0,2993883 ! glutamine family amino acid metabolic process GO:0009064 59 47 0,000 0,27882163 0,2992486 ! regulation of neuron apoptosis GO:0043523 77 47 0,000 0,27882163 0,29910902 ! regulation of protein polymerization GO:0032271 71 47 0,000 0,27882163 0,29896958 ! chloride transport GO:0006821 67 48 0,000 0,28382665 0,30419445 ! regulation of muscle contraction GO:0006937 69 48 0,000 0,28382665 0,30405277 ! response to temperature stimulus GO:0009266 62 48 0,000 0,28382665 0,30391122 ! cellular polysaccharide metabolic process GO:0044264 63 48 0,000 0,28382665 0,3037698 ! regulation of actin polymerization or depolymerization GO:0008064 68 48 0,000 0,28382665 0,30362851 ! gastrulation GO:0007369 73 48 0,000 0,28382665 0,30348735 ! positive regulation of lyase activity GO:0051349 88 48 0,000 0,28382665 0,30334633 ! aminoglycan metabolic process GO:0006022 72 49 0,000 0,28879722 0,30851538 ! sensory perception of smell GO:0007608 61 49 0,000 0,28879722 0,30837215 ! sulfur compound biosynthetic process GO:0044272 62 49 0,000 0,28879722 0,30822905 ! RNA elongation GO:0006354 62 49 0,000 0,28879722 0,30808609 ! germ cell development GO:0007281 68 49 0,000 0,28879722 0,30794326 ! heterocycle catabolic process GO:0046700 72 49 0,000 0,28879722 0,30780056 ! integrin-mediated signaling pathway GO:0007229 81 49 0,000 0,28879722 0,307658 ! regulation of actin filament length GO:0030832 72 50 0,000 0,29373358 0,31277187 ! membrane fusion GO:0006944 80 50 0,000 0,29373358 0,31262713 ! proton transport GO:0015992 75 50 0,000 0,29373358 0,31248253 ! cellular amino acid derivative biosynthetic process GO:0042398 68 50 0,000 0,29373358 0,31233807 ! positive regulation of secretion GO:0051047 71 51 0,000 0,29863596 0,31740421 ! hydrogen transport GO:0006818 77 51 0,000 0,29863596 0,3172576 ! positive regulation of organelle organization GO:0010638 82 51 0,000 0,29863596 0,31711113 ! adult behavior GO:0030534 80 51 0,000 0,29863596 0,31696479 ! transition metal ion transport GO:0000041 74 52 0,000 0,30350459 0,32198365 ! regulation of cellular component size GO:0032535 74 52 0,000 0,30350459 0,3218352 ! nucleotide-excision repair GO:0006289 64 52 0,000 0,30350459 0,32168689 ! sphingolipid metabolic process GO:0006665 72 52 0,000 0,30350459 0,32153871 ! regulation of neurotransmitter levels GO:0001505 73 53 0,000 0,3083397 0,32651073 ! single fertilization GO:0007338 59 53 0,000 0,3083397 0,32636047 ! amino acid transport GO:0006865 84 54 0,000 0,31314151 0,33129047 ! regulation of mitosis GO:0007088 84 54 0,000 0,31314151 0,33113815 GO:0051783|regulation of nuclear division, ! cytokine-mediated signaling pathway GO:0019221 76 54 0,000 0,31314151 0,33098597 ! cellular amino acid catabolic process GO:0009063 74 54 0,000 0,31314151 0,33083394 ! exocytosis GO:0006887 74 55 0,000 0,31791027 0,33571792 ! mesoderm development GO:0007498 76 55 0,000 0,31791027 0,33556385 ! water-soluble vitamin metabolic process GO:0006767 71 55 0,000 0,31791027 0,33540992 ! negative regulation of response to stimulus GO:0048585 80 56 0,000 0,32264619 0,34025045 ! carbohydrate transport GO:0008643 74 57 0,000 0,32734949 0,34505217 ! chromosome segregation GO:0007059 83 57 0,000 0,32734949 0,34489411 ! coenzyme biosynthetic process GO:0009108 67 57 0,000 0,32734949 0,34473619 ! membrane lipid metabolic process GO:0006643 79 57 0,000 0,32734949 0,34457842 ! secondary metabolic process GO:0019748 84 57 0,000 0,32734949 0,34442079 ! developmental maturation GO:0021700 75 57 0,000 0,32734949 0,3442633 ! regulation of cytokine biosynthetic process GO:0042035 76 58 0,000 0,33202041 0,34901597 ! protein maturation by peptide bond cleavage GO:0051605 76 58 0,000 0,33202041 0,34885653 ! actin filament organization GO:0007015 95 59 0,000 0,33665916 0,35356898 ! G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 90 60 0,000 0,34126596 0,35824359 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051436 88 60 0,000 0,34126596 0,35808015 ! regulation of heart contraction GO:0008016 91 60 0,000 0,34126596 0,35791687 ! fertilization GO:0009566 68 60 0,000 0,34126596 0,35775374 ! regulation of cellular response to stress GO:0080135 85 61 0,000 0,34584102 0,36238467 ! cell-matrix adhesion GO:0007160 114 61 0,000 0,34584102 0,36221965 ! lipoprotein metabolic process GO:0042157 89 61 0,000 0,34584102 0,36205478 ! homeostasis of number of cells GO:0048872 84 61 0,000 0,34584102 0,36189006 ! extracellular matrix organization GO:0030198 103 61 0,000 0,34584102 0,36172549 ! negative regulation of ligase activity GO:0051352 91 61 0,000 0,34584102 0,36156107 GO:0051444|negative regulation of ubiquitin-protein ligase activity, ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 88 61 0,000 0,34584102 0,3613968 ! amine catabolic process GO:0009310 90 62 0,000 0,35038458 0,36597844 ! neurotransmitter transport GO:0006836 81 62 0,000 0,35038458 0,36581231 ! cellular hormone metabolic process GO:0034754 87 62 0,000 0,35038458 0,36564634 ! negative regulation of cell growth GO:0030308 106 62 0,000 0,35038458 0,36548051 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051437 89 62 0,000 0,35038458 0,36531483 ! cAMP-mediated signaling GO:0019933 97 63 0,000 0,35489683 0,3698517 ! cell cycle checkpoint GO:0000075 108 64 0,000 0,359378 0,37435208 ! negative regulation of cell size GO:0045792 108 64 0,000 0,359378 0,37418262 ! neuropeptide signaling pathway GO:0007218 79 64 0,000 0,359378 0,3740133 ! positive regulation of ubiquitin-protein ligase activity GO:0051443 92 65 0,000 0,3638283 0,37847358 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle GO:0051439 95 65 0,000 0,3638283 0,37830248 ! defense response to bacterium GO:0042742 73 65 0,000 0,3638283 0,37813153 ! regulation of MAPKKK cascade GO:0043408 101 65 0,000 0,3638283 0,37796074 ! positive regulation of T cell activation GO:0050870 94 65 0,000 0,3638283 0,3777901 ! activation of immune response GO:0002253 83 65 0,000 0,3638283 0,37761962 ! cell-substrate adhesion GO:0031589 121 66 0,000 0,36824793 0,38203439 ! regulation of immune effector process GO:0002697 101 66 0,000 0,36824793 0,38186215 ! elevation of cytosolic calcium ion concentration GO:0007204 105 67 0,000 0,37263711 0,38623946 ! acute inflammatory response GO:0002526 92 68 0,000 0,37699605 0,39058149 ! learning or memory GO:0007611 123 68 0,000 0,37699605 0,39040564 ! cytosolic calcium ion homeostasis GO:0051480 107 68 0,000 0,37699605 0,39022994 ! intracellular protein transmembrane transport GO:0065002 102 68 0,000 0,37699605 0,39005439 ! regulation of Ras GTPase activity GO:0032318 110 68 0,000 0,37699605 0,38987901 ! inorganic anion transport GO:0015698 93 68 0,000 0,37699605 0,38970378 ! sensory perception of chemical stimulus GO:0007606 85 69 0,000 0,38132495 0,39400152 ! positive regulation of ligase activity GO:0051351 99 69 0,000 0,38132495 0,3938246 ! response to metal ion GO:0010038 103 70 0,000 0,38562402 0,39808584 ! humoral immune response GO:0006959 86 70 0,000 0,38562402 0,39790724 ! amine transport GO:0015837 101 70 0,000 0,38562402 0,39772881 ! transcription initiation from RNA polymerase II promoter GO:0006367 91 70 0,000 0,38562402 0,39755054 ! muscle cell differentiation GO:0042692 104 71 0,000 0,38989346 0,40177193 ! regulation of ubiquitin-protein ligase activity GO:0051438 107 71 0,000 0,38989346 0,40159201 ! regulation of synaptic transmission GO:0050804 109 72 0,000 0,39413347 0,40577753 ! cellular lipid catabolic process GO:0044242 105 73 0,000 0,39834426 0,40992922 ! response to steroid hormone stimulus GO:0048545 114 73 0,000 0,39834426 0,40974589 ! digestion GO:0007586 97 74 0,000 0,40252603 0,41386226 ! protein import into nucleus GO:0006606 118 74 0,000 0,40252603 0,41367733 ! positive regulation of lymphocyte activation GO:0051251 108 74 0,000 0,40252603 0,41349257 ! response to inorganic substance GO:0010035 115 75 0,000 0,40667897 0,41757215 ! negative regulation of growth GO:0045926 123 75 0,000 0,40667897 0,41738582 ! response to nutrient GO:0007584 104 75 0,000 0,40667897 0,41719965 ! regulation of ligase activity GO:0051340 114 75 0,000 0,40667897 0,41701365 ! nuclear import GO:0051170 121 75 0,000 0,40667897 0,41682782 ! cofactor biosynthetic process GO:0051188 92 75 0,000 0,40667897 0,41664215 ! amine biosynthetic process GO:0009309 97 76 0,000 0,41080328 0,42068011 ! tRNA metabolic process GO:0006399 95 76 0,000 0,41080328 0,4204929 ! response to unfolded protein GO:0006986 99 76 0,000 0,41080328 0,42030584 ! regulation of adenylate cyclase activity GO:0045761 131 77 0,000 0,41489915 0,42430771 ! regulation of transmission of nerve impulse GO:0051969 116 77 0,000 0,41489915 0,42411913 ! carbohydrate biosynthetic process GO:0016051 97 77 0,000 0,41489915 0,42393072 ! nitrogen compound catabolic process GO:0044270 114 78 0,000 0,41896679 0,42789681 ! regulation of cyclase activity GO:0031279 132 78 0,000 0,41896679 0,42770688 ! regulation of cAMP biosynthetic process GO:0030817 136 79 0,000 0,42300638 0,43163916 ! regulation of lyase activity GO:0051339 133 79 0,000 0,42300638 0,43144775 ! ATP biosynthetic process GO:0006754 118 79 0,000 0,42300638 0,4312565 ! chromatin assembly GO:0031497 102 80 0,000 0,42701811 0,43515359 GO:0006334|nucleosome assembly, ! proteasomal ubiquitin-dependent protein catabolic process GO:0043161 118 80 0,000 0,42701811 0,43496088 GO:0010498|proteasomal protein catabolic process, ! protein localization in nucleus GO:0034504 133 80 0,000 0,42701811 0,43476833 ! regulation of GTPase activity GO:0043087 129 80 0,000 0,42701811 0,43457595 ! regulation of cAMP metabolic process GO:0030814 141 81 0,000 0,43100218 0,43843654 ! mRNA transport GO:0051028 121 81 0,000 0,43100218 0,43824272 ! response to protein stimulus GO:0051789 111 81 0,000 0,43100218 0,43804906 ! regulation of neurological system process GO:0031644 122 81 0,000 0,43100218 0,43785558 ! vitamin metabolic process GO:0006766 103 81 0,000 0,43100218 0,43766226 ! positive regulation of cell activation GO:0050867 120 81 0,000 0,43100218 0,43746912 GO:0002696|positive regulation of leukocyte activation, ! ossification GO:0001503 134 82 0,000 0,43495878 0,44129034 GO:0060348|bone development, ! regulation of nucleotide biosynthetic process GO:0030808 141 83 0,000 0,43888809 0,44508051 GO:0030802|regulation of cyclic nucleotide biosynthetic process, ! biogenic amine metabolic process GO:0006576 121 83 0,000 0,43888809 0,44488436 ! protein-DNA complex assembly GO:0065004 107 84 0,000 0,4427903 0,44864215 ! Golgi vesicle transport GO:0048193 138 85 0,000 0,44666559 0,45236938 ! negative regulation of multicellular organismal process GO:0051241 133 85 0,000 0,44666559 0,45217028 ! regulation of cyclic nucleotide metabolic process GO:0030799 147 86 0,000 0,45051416 0,45586562 ! nucleosome organization GO:0034728 114 87 0,000 0,45433617 0,45953087 ! purine ribonucleoside triphosphate biosynthetic process GO:0009206 126 87 0,000 0,45433617 0,45932888 GO:0009145|purine nucleoside triphosphate biosynthetic process, ! cellular defense response GO:0006968 102 87 0,000 0,45433617 0,45912706 ! female pregnancy GO:0007565 130 87 0,000 0,45433617 0,45892543 ! ribonucleoside triphosphate biosynthetic process GO:0009201 127 88 0,000 0,45813182 0,46255627 ! carboxylic acid catabolic process GO:0046395 122 88 0,000 0,45813182 0,46235331 GO:0016054|organic acid catabolic process, ! establishment of RNA localization GO:0051236 128 88 0,000 0,45813182 0,46215052 GO:0050658|RNA transport, GO:0050657|nucleic acid transport, ! nucleoside triphosphate biosynthetic process GO:0009142 128 89 0,000 0,46190129 0,46574878 ! regulation of nucleotide metabolic process GO:0006140 150 89 0,000 0,46190129 0,46554468 ! hormone metabolic process GO:0042445 121 90 0,000 0,46564474 0,46911209 ! RNA localization GO:0006403 135 91 0,000 0,46936237 0,47265037 ! ATP metabolic process GO:0046034 137 91 0,000 0,46936237 0,47244352 ! response to virus GO:0009615 122 91 0,000 0,46936237 0,47223686 ! positive regulation of immune response GO:0050778 121 92 0,000 0,47305435 0,47574333 ! polysaccharide metabolic process GO:0005976 129 93 0,000 0,47672085 0,47922113 ! angiogenesis GO:0001525 149 95 0,000 0,48397811 0,48630391 ! carboxylic acid transport GO:0046942 147 95 0,000 0,48397811 0,48609155 GO:0015849|organic acid transport, ! in utero embryonic development GO:0001701 147 96 0,000 0,48756922 0,4894846 ! nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0015931 138 96 0,000 0,48756922 0,48927103 ! protein amino acid glycosylation GO:0006486 134 97 0,000 0,49113555 0,49263487 GO:0043413|biopolymer glycosylation, GO:0070085|glycosylation, ! positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 143 97 0,000 0,49113555 0,49242012 ! calcium ion transport GO:0006816 167 99 0,000 0,49819452 0,49927991 ! protein import GO:0017038 156 99 0,000 0,49819452 0,49906245 ! homophilic cell adhesion GO:0007156 149 100 0,000 0,5016875 0,50234273 ! purine ribonucleoside triphosphate metabolic process GO:0009205 146 100 0,000 0,5016875 0,50212413 ! divalent metal ion transport GO:0070838 171 100 0,000 0,5016875 0,50190572 ! protein localization in organelle GO:0033365 161 100 0,000 0,5016875 0,5016875